molecular epidemiology


Summary: The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.

Top Publications

  1. pmc Evolution and molecular epidemiology of subtype C HIV-1 in Zimbabwe
    Sudeb C Dalai
    Stanford University School of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    AIDS 23:2523-32. 2009
  2. ncbi Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control
    Santiago Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    Adv Parasitol 69:41-146. 2009
  3. ncbi The molecular epidemiology and evolution of the Panton-Valentine leukocidin-positive, methicillin-resistant Staphylococcus aureus strain USA300 in Western Australia
    S Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, D 01307 Dresden, Germany
    Clin Microbiol Infect 15:770-6. 2009
  4. pmc Molecular epidemiology of HCV monoinfection and HIV/HCV coinfection in injection drug users in Liuzhou, Southern China
    Yi Tan
    Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 3:e3608. 2008
  5. pmc Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention
    Michel Pepin
    AFSSA site de Lyon, Lyon Cedex, France
    Vet Res 41:61. 2010
  6. pmc Bayesian phylogeography finds its roots
    Philippe Lemey
    Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS Comput Biol 5:e1000520. 2009
  7. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
  8. pmc Global trends in molecular epidemiology of HIV-1 during 2000-2007
    Joris Hemelaar
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, UK
    AIDS 25:679-89. 2011
  9. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
  10. pmc Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis
    Hajo Grundmann
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS Med 7:e1000215. 2010

Detail Information

Publications386 found, 100 shown here

  1. pmc Evolution and molecular epidemiology of subtype C HIV-1 in Zimbabwe
    Sudeb C Dalai
    Stanford University School of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    AIDS 23:2523-32. 2009
    ..To investigate the origins and evolutionary history of subtype C HIV-1 in Zimbabwe in a context of regional conflict and migration...
  2. ncbi Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control
    Santiago Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    Adv Parasitol 69:41-146. 2009
    ..A complete understanding of molecular epidemiology is expected to help greatly in designing global actions and local interventions for control of fascioliasis...
  3. ncbi The molecular epidemiology and evolution of the Panton-Valentine leukocidin-positive, methicillin-resistant Staphylococcus aureus strain USA300 in Western Australia
    S Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, D 01307 Dresden, Germany
    Clin Microbiol Infect 15:770-6. 2009
    ..The present study emphasises the importance of genotyping in detecting the introduction and evolution of significant MRSA strains within a community...
  4. pmc Molecular epidemiology of HCV monoinfection and HIV/HCV coinfection in injection drug users in Liuzhou, Southern China
    Yi Tan
    Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 3:e3608. 2008
    ..Access to harm reduction measures is opening up opportunities for improving the HIV/HCV profiling of IDU in China, where IDUs account for a significant proportion of the two infections especially in the southern part of the country...
  5. pmc Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention
    Michel Pepin
    AFSSA site de Lyon, Lyon Cedex, France
    Vet Res 41:61. 2010
  6. pmc Bayesian phylogeography finds its roots
    Philippe Lemey
    Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS Comput Biol 5:e1000520. 2009
    ..From these analyses, we conclude that our phylogeographic framework will make an important asset in molecular epidemiology that can be easily generalized to infer biogeogeography from genetic data for many organisms.
  7. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
  8. pmc Global trends in molecular epidemiology of HIV-1 during 2000-2007
    Joris Hemelaar
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, UK
    AIDS 25:679-89. 2011
    ..To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007...
  9. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
    ..These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development...
  10. pmc Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis
    Hajo Grundmann
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS Med 7:e1000215. 2010
    ..We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe...
  11. ncbi Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet
    Efrain M Ribot
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:59-67. 2006
  12. pmc Zoonotic potential and molecular epidemiology of Giardia species and giardiasis
    Yaoyu Feng
    State Key Laboratory of Bioreactor Engineering, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, China
    Clin Microbiol Rev 24:110-40. 2011
    ..Nevertheless, our efforts in characterizing the molecular epidemiology of giardiasis and the roles of various animals in the transmission of human giardiasis are compromised by ..
  13. pmc Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998
    B A Brown
    Division of Viral Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Virol 73:9969-75. 1999
    ..Its worldwide circulation and potential to cause severe disease underscore the need for additional surveillance and improved methods to identify EV71 in human disease...
  14. pmc A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)
    S E Kidd
    Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Proc Natl Acad Sci U S A 101:17258-63. 2004
    ..The emergence of this usually tropical pathogen on Vancouver Island highlights the changing distribution of this genotype and emphasizes the importance of an ongoing collaborative effort to monitor the global epidemiology of this yeast...
  15. ncbi Recent advances in the molecular epidemiology and control of human enterovirus 71 infection
    Peter C McMinn
    Infectious Diseases and Immunology, Sydney Medical School, The University of Sydney, NSW 2006, Australia
    Curr Opin Virol 2:199-205. 2012
    ..Furthermore, ongoing investigations into the molecular basis of HEV71 infection and virulence have pointed the way towards novel approaches to live attenuated vaccine development...
  16. ncbi Molecular epidemiology of cryptosporidiosis: an update
    Lihua Xiao
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Bldg 22, Rm 14, 4770 Burford Highway, Atlanta, GA 30341, USA
    Exp Parasitol 124:80-9. 2010
    ..The wide use of a new generation of genotyping and subtyping tools in well designed epidemiologic studies should lead to a more in-depth understanding of the epidemiology of cryptosporidiosis in humans and animals...
  17. pmc Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolates
    Caroline Allix-Béguec
    Genoscreen, 1, rue du Professeur Calmette, Lille 59019 Cedex, France
    J Clin Microbiol 46:2692-9. 2008
    ..The MIRU-VNTRplus database is a powerful tool for high-resolution clonal identification and has little equivalent in terms of functionalities among the bacterial genotyping databases available so far...
  18. pmc Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
    Brandon F Keele
    Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Science 313:523-6. 2006
    ..These findings establish P. t. troglodytes as a natural reservoir of HIV-1...
  19. ncbi Clinical and molecular epidemiology of norovirus infection in childhood diarrhea in China
    Mei Zeng
    Department of Infectious Diseases and Research Laboratory of Infectious Diseases, Children s Hospital of Fudan University, Shanghai, China
    J Med Virol 84:145-51. 2012
    ..The results show that NoV GII.4 2006b was the predominant strain circulating in China between 2008 and 2009...
  20. ncbi Molecular epidemiology of foot-and-mouth disease virus
    N J Knowles
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK nick knowles bbsrc ac uk
    Virus Res 91:65-80. 2003
    ..An increased understanding of how FMDV strains move between geographic regions will play a pivotal role in the development of future disease control strategies...
  21. pmc Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes
    Mary Jane Cardosa
    Universiti Malaysia Sarawak, Sarawak, Malaysia
    Emerg Infect Dis 9:461-8. 2003
    This study provides a comprehensive overview of the molecular epidemiology of human enterovirus 71 (HEV71) in the Asia-Pacific region from 1997 through 2002...
  22. ncbi Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes
    Helene Norder
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    Intervirology 47:289-309. 2004
  23. ncbi Molecular epidemiology of American tegumentary leishmaniasis in Panama
    Aracelis Miranda
    Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City, Panama
    Am J Trop Med Hyg 81:565-71. 2009
    ..This study describes the clinical characteristics and the molecular epidemiology of leishmaniasis in Panama over a 5-year period (2004-2008)...
  24. ncbi Molecular epidemiology of malaria prevalence and parasitaemia in a wild bird population
    Sarah C L Knowles
    Department of Zoology, Edward Grey Institute, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Mol Ecol 20:1062-76. 2011
  25. pmc Local population structure of Plasmodium: impact on malaria control and elimination
    Stella M Chenet
    School of Life Sciences, Arizona State University, Tempe, AZ, USA
    Malar J 11:412. 2012
    ..The study was performed in a low-transmission area, which offers a good proxy to better understand problems associated with surveillance at the final stages of malaria elimination...
  26. ncbi Molecular epidemiology of tuberculosis
    Peter F Barnes
    Center for Pulmonary and Infectious Disease Control, Department of Medicine, University of Texas Health Center, Tyler, TX 75708 3154, USA
    N Engl J Med 349:1149-56. 2003
  27. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
    ..Despite its prevalence, the phylogeography and molecular epidemiology of Y. pestis in Madagascar has been difficult to study due to the great genetic similarity among isolates...
  28. ncbi Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients
    Maurizia Debiaggi
    Department of Morphological and Clinical Sciences, Section of Microbiology, University of Pavia, Pavia, Italy
    J Med Virol 82:153-6. 2010
    ..The results suggest that WU/KIPyVs have a limited circulation in Italy and a low pathogenic potential in young children. Brief and asymptomatic infection can occur in hematopoietic transplant recipients...
  29. ncbi Molecular epidemiology of Yersinia enterocolitica infections
    Maria Fredriksson-Ahomaa
    Institute of Hygiene and Technology of Food of Animal Origin, Ludwig Maximilian University, Munich, Germany
    FEMS Immunol Med Microbiol 47:315-29. 2006
    ..Indistinguishable genotypes have also been found between human strains and dog, cat, sheep and wild rodent strains, indicating that these animals are other possible infection sources for humans...
  30. ncbi Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains
    Ida Parwati
    Department of Clinical Pathology, Medical Faculty, Padjadjaran University, Dr Hasan Sadikin Hospital, Bandung, Indonesia
    Lancet Infect Dis 10:103-11. 2010
    ..More research is needed to further unravel the mechanisms underlying the emergence of M tuberculosis Beijing genotype strains, and examine the implications for future control strategies...
  31. ncbi Escherichia coli sequence type ST131 as the major cause of serious multidrug-resistant E. coli infections in the United States
    James R Johnson
    Infectious Diseases, VA Medical Center, Minneapolis, MN 55417, USA
    Clin Infect Dis 51:286-94. 2010
    ..Escherichia coli sequence type ST131 (O25:H4), associated with the CTX-M-15 extended-spectrum beta-lactamase, has emerged internationally as a multidrug-resistant pathogen but has received little attention in the United States...
  32. pmc Molecular epidemiology of genogroup II-genotype 4 noroviruses in the United States between 1994 and 2006
    Du Ping Zheng
    Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 48:168-77. 2010
    ..We propose that GII.4 subclusters be defined as having >5% sequence variation between strains. Our data confirm other studies on the rapid emergence and displacement of highly virulent GII.4 strains...
  33. pmc Based Upon Repeat Pattern (BURP): an algorithm to characterize the long-term evolution of Staphylococcus aureus populations based on spa polymorphisms
    Alexander Mellmann
    Institute for Hygiene, University Hospital Munster, Munster, Germany
    BMC Microbiol 7:98. 2007
    ..BURP was subsequently evaluated with a strain collection reflecting the breadth of diversity of S. aureus (JCM 2002; 40:4544)...
  34. ncbi Molecular epidemiology of Escherichia coli producing CTX-M beta-lactamases: the worldwide emergence of clone ST131 O25:H4
    Gisele Peirano
    Division of Microbiology, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Int J Antimicrob Agents 35:316-21. 2010
  35. pmc The past and future of tuberculosis research
    Iñaki Comas
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    PLoS Pathog 5:e1000600. 2009
    ..We argue here, however, that new multidisciplinary approaches--especially the integration of epidemiology with systems biology in what we call "systems epidemiology"--will be required to eliminate TB...
  36. ncbi Hepatitis B virus genotypes
    Anna Kramvis
    MRC University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193 Johannesburg, South Africa
    Vaccine 23:2409-23. 2005
    ..Although the number of studies on these genotypes has increased dramatically during recent years, much remains to be learnt about their full implications...
  37. ncbi Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scales
    Paul Keim
    Keim Genetics Laboratory, Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    Infect Genet Evol 4:205-13. 2004
    ..This approach mitigates the need for data weighting and provides both a deeply rooted phylogenetic hypothesis and high resolution discrimination among closely related isolates...
  38. ncbi Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Europe
    Jonathan A Otter
    Department of Infection, King s College London and St Thomas Hospital, London, UK
    Lancet Infect Dis 10:227-39. 2010
    ..An understanding of the epidemiology of community-associated MRSA is essential to guide new control initiatives to prevent these organisms from becoming endemic in Europe...
  39. pmc Molecular epidemiology of dengue viruses in southern China from 1978 to 2006
    Weili Wu
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China
    Virol J 8:322. 2011
    To investigate molecular epidemiology of dengue viruses (DENV) in southern China, a total of 14 dengue isolates were collected in southern China during each epidemic year between 1978 and 2006 and their full-length genome sequences were ..
  40. pmc Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia
    Thi Ty Hang Vu
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Negl Trop Dis 4:e757. 2010
    ..These results provide a mechanistic basis to a marked change in the genetic structure of DENV-2 and more broadly underscore that an understanding of DENV evolutionary dynamics can inform the development of vaccines and anti-viral drugs...
  41. ncbi Prevalence and molecular epidemiology of meticillin-resistant Staphylococcus aureus in nursing home residents in northern Germany
    S Pfingsten-Würzburg
    Städtisches Gesundheitsamt, Braunschweig, Germany
    J Hosp Infect 78:108-12. 2011 infection control and healthcare network initiatives, we investigated the point prevalence and molecular epidemiology of MRSA colonisation among nursing home residents in Brunswick, northern Germany...
  42. pmc Molecular epidemiology and evolution of human enterovirus serotype 68 in Thailand, 2006-2011
    Piyada Linsuwanon
    Chulalongkorn University, Bangkok, Thailand
    PLoS ONE 7:e35190. 2012
    ..However, epidemiological data regarding this virus in particular on the Asian continent has so far been limited...
  43. ncbi HIV-1 molecular epidemiology evidence and transmission patterns in the Middle East and North Africa
    Ghina Mumtaz
    Infectious Disease Epidemiology Group, Weill Cornell Medical College Qatar, Qatar Foundation, Education City, P O Box 24144, Doha, Qatar
    Sex Transm Infect 87:101-6. 2011
    ..This study is a systematic review of all available evidence on HIV-1 molecular epidemiology and subtype distribution in the Middle East and North Africa...
  44. ncbi Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus
    M Widerström
    Department of Infectious Diseases, Ostersund Hospital, Ostersund, Sweden
    Eur J Clin Microbiol Infect Dis 31:7-20. 2012
    ..In the following mini-review, we summarize recent research in this area focusing on the molecular methods and epidemiology of S. epidermidis and S. saprophyticus...
  45. pmc Inadequacies of minimum spanning trees in molecular epidemiology
    Stephen J Salipante
    Bellingham Research Institute, Bellingham, Washington, USA
    J Clin Microbiol 49:3568-75. 2011
    Minimum spanning trees (MSTs) are frequently used in molecular epidemiology research to estimate relationships among individual strains or isolates...
  46. pmc Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island
    James R Johnson
    Medical Service, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Clin Microbiol 46:3906-11. 2008
    ..This extends previous work regarding the pks island and supports investigation of the colibactin system as a potential therapeutic target...
  47. ncbi Molecular epidemiology of extraintestinal pathogenic Escherichia coli isolates from a regional cohort of elderly patients highlights the prevalence of ST131 strains with increased antimicrobial resistance in both community and hospital care settings
    Gemma Croxall
    Pathogen Research Group, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    J Antimicrob Chemother 66:2501-8. 2011
    To assess the molecular epidemiology and prevalence of antibiotic resistance in Escherichia coli causing urinary tract infections of elderly patients from community and hospital settings...
  48. pmc Molecular epidemiology of HIV-1 subtypes in India: origin and evolutionary history of the predominant subtype C
    Ujjwal Neogi
    Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e39819. 2012
    ..We also reconstructed the time to the most recent common ancestor (tMRCA) of the predominant HIV-1C strains...
  49. pmc Molecular epidemiology of Rift Valley fever virus
    Antoinette A Grobbelaar
    National Institute for Communicable Diseases of the National Health Service, Sandringham, South Africa
    Emerg Infect Dis 17:2270-6. 2011
    ..The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed...
  50. pmc High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology
    E Mazars
    , , U447, Institut Pasteur de Lille, rue du Prof. Calmette, F-59019 Lille Cedex, France
    Proc Natl Acad Sci U S A 98:1901-6. 2001
    ..This typing method opens the way to the construction of digital global databases for molecular epidemiology studies of M. tuberculosis.
  51. pmc Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258
    Brandon Kitchel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 53:3365-70. 2009
    ..We used pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) to examine the molecular epidemiology of KPC-producing K...
  52. pmc Molecular phylodynamics of the heterosexual HIV epidemic in the United Kingdom
    Gareth J Hughes
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS Pathog 5:e1000590. 2009
    ..More effective intervention to restrict the epidemic may therefore be feasible, given effective diagnosis programmes...
  53. ncbi Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:434-42. 2004
    ..We show how this approach can lead to improvements in the design, analysis, and interpretation of molecular epidemiology studies...
  54. pmc Assessment of an optimized mycobacterial interspersed repetitive- unit-variable-number tandem-repeat typing system combined with spoligotyping for population-based molecular epidemiology studies of tuberculosis
    Mara Cardoso Oelemann
    INSERM, U629, Institut Pasteur de Lille, Lille, France
    J Clin Microbiol 45:691-7. 2007
    ..tuberculosis transmission...
  55. ncbi Polymorphisms in microRNA targets: a gold mine for molecular epidemiology
    Kexin Chen
    Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Tianjin 300060, People s Republic of China
    Carcinogenesis 29:1306-11. 2008
    ..The biological relevance of these polymorphisms in predicted microRNA-binding sites is beginning to be examined in large case-control studies...
  56. pmc spa Typing of Staphylococcus aureus as a frontline tool in epidemiological typing
    B Strommenger
    Robert Koch Institute, Wernigerode Branch, Burgstr 37, D 38855 Wernigerode, Germany
    J Clin Microbiol 46:574-81. 2008
    ..They should be selected by dependence on the clonal lineage indicated by spa typing and subsequent BURP analysis as well as on the basis of the particular question to be addressed...
  57. ncbi Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    J Cell Mol Med 16:8-21. 2012
    ..In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers...
  58. ncbi Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology
    Christopher Paul Wild
    Cancer Epidemiol Biomarkers Prev 14:1847-50. 2005
  59. ncbi Newcastle disease: evolution of genotypes and the related diagnostic challenges
    Patti J Miller
    Exotic and Emerging Avian Viral Diseases Research Unit, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30052, USA
    Infect Genet Evol 10:26-35. 2010
    ..Here, we review the molecular epidemiology and recent diagnostic problems related to viral evolution of NDV and explain why a new system, based on ..
  60. ncbi Molecular epidemiological analysis of Japanese encephalitis virus in China
    Huan Yu Wang
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 YingXinJie, XuanWuQu, Beijing 100052, People s Republic of China
    J Gen Virol 88:885-94. 2007
    ..The results suggest that genotype 1 JEV was introduced to China around 1979 and that JEV strains belonging to genotypes 1 and 3 circulate in China...
  61. ncbi Epidemiologic and molecular trends of "Norwalk-like viruses" associated with outbreaks of gastroenteritis in the United States
    Rebecca L Fankhauser
    Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:1-7. 2002
    ..Strain diversity was great: one potential new sequence cluster was implicated in multiple outbreaks, and strains belonging to a tentative new genogroup were identified...
  62. ncbi The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future
    M A Miles
    Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Parasitology 136:1509-28. 2009
    ..b>Molecular epidemiology has substantially resolved the phylogeography and ecological niches of the T. cruzi lineages...
  63. pmc Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network
    L McGee
    MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
    J Clin Microbiol 39:2565-71. 2001
    ..The Pneumococcal Molecular Epidemiology Network was established in 1997 under the auspices of the International Union of Microbiological Societies ..
  64. ncbi Molecular epidemiology of Cryptosporidium in livestock animals and humans in the Ismailia province of Egypt
    Yosra A Helmy
    Department of Animal Hygiene, Zoonoses and Animal Ethology, Faculty of Veterinary Medicine, Suez Canal University, 41511 Ismailia, Egypt
    Vet Parasitol 193:15-24. 2013
    ..High prevalence and identical genotypes of C. parvum in animals and humans indicate zoonotic transmission due to contact with animals, involving IIdA20G1 as the most frequent subtype...
  65. pmc Phylogeography of recently emerged DENV-2 in southern Viet Nam
    Maia A Rabaa
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Negl Trop Dis 4:e766. 2010
    ..However, these data also indicate that more rural areas are also capable of maintaining virus populations and hence fueling DENV evolution over multiple seasons...
  66. ncbi Global distribution of measles genotypes and measles molecular epidemiology
    Paul A Rota
    World Health Organization WHO Global Specialized Laboratory, Atlanta, Georgia 30333, USA
    J Infect Dis 204:S514-23. 2011
    ..The future challenges will be to develop quality control programs for molecular methods and to continue to expand virologic surveillance activities in all regions...
  67. pmc Natural history of human respiratory syncytial virus inferred from phylogenetic analysis of the attachment (G) glycoprotein with a 60-nucleotide duplication
    Alfonsina Trento
    Unidad de Biología Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
    J Virol 80:975-84. 2006
    ..We have taken advantage of this situation to reexamine the molecular epidemiology of HRSV and to explore the natural history of this important human pathogen.
  68. pmc Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections
    Kristen Chalmet
    Ghent University, Belgium
    BMC Infect Dis 10:262. 2010
  69. ncbi Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  70. pmc Molecular epidemiology of extended-spectrum beta-lactamases among Escherichia coli isolates collected in a Swedish hospital and its associated health care facilities from 2001 to 2006
    Hong Fang
    Department of Clinical Microbiology, F68, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    J Clin Microbiol 46:707-12. 2008
    The genetic characteristics and molecular epidemiology of extended-spectrum beta-lactamases (ESBLs) among Escherichia coli isolates were investigated at a general hospital and its associated health care facilities in Stockholm, Sweden, ..
  71. pmc Genetic polymorphism and molecular epidemiology of Leishmania (Viannia) braziliensis from different hosts and geographic areas in Brazil
    Elisa Cupolillo
    Laboratório de Pesquisas em Leishmaniose Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    J Clin Microbiol 41:3126-32. 2003
    ..V.) braziliensis genotypes with specific transmission cycles, probably reflecting an adaptation of different clones to the vector species involved...
  72. pmc New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses
    Caroline Tapparel
    University of Geneva Hospitals, Switzerland
    Emerg Infect Dis 15:719-26. 2009
    ..This study clarifies the diversity and explains the reasons for evolution of these viruses...
  73. ncbi Molecular epidemiology of enterovirus 71 in peninsular Malaysia, 1997-2000
    L J Herrero
    Division of Virology, Telethon Institute for Child Health Research, Subiaco, WA, Australia
    Arch Virol 148:1369-85. 2003
    ..Subgenogroup C1 also displayed endemic circulation from 1997 to 2000 and subgenogroup C2 was present at a low level during the 1997 outbreak...
  74. pmc Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei
    Horng Yunn Dou
    Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    BMC Infect Dis 8:170. 2008
    ..Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture...
  75. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
    ..This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria...
  76. ncbi Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey
    Stan Deresinski
    Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
    Clin Infect Dis 40:562-73. 2005
    ..This has led to an important change in the choice of antibiotics in the management of community-acquired infections and has also led to the development of novel antimicrobials...
  77. ncbi Molecular epidemiology of current classical swine fever virus isolates of wild boar in Germany
    Immanuel Leifer
    Institute of Diagnostic Virology, Friedrich Loeffler Institut, Südufer 10, D 17493 Greifswald Insel Riems, Germany
    J Gen Virol 91:2687-97. 2010
    ..Furthermore, there are no detailed analyses of the molecular epidemiology of CSFV wild boar isolates available...
  78. pmc Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands
    Hendrik I J Roest
    Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands
    Emerg Infect Dis 17:668-75. 2011
    ..On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands...
  79. pmc Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:11152-66. 2008
  80. pmc Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia
    Kok Keng Tee
    Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Virol 82:9206-15. 2008
    ..This is the first phylodynamic study depicting the spatiotemporal dynamics of HIV/AIDS in East Asia...
  81. pmc Host association of Campylobacter genotypes transcends geographic variation
    Samuel K Sheppard
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Appl Environ Microbiol 76:5269-77. 2010
    ..These findings are consistent with local and international transmission of host-associated lineages among food animal species and provide a foundation for further improvements in genetic attribution...
  82. pmc Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States
    Edmond J Byrnes
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 199:1081-6. 2009
    ..Multilocus sequence typing demonstrates the spread of C. gattii VGIIa and VGIIb from Vancouver Island to the Pacific Northwest. Clinical strains recovered in Oregon represent a unique VGIIc genotype...
  83. ncbi Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
    S P Chen
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongdajie Street, Fengtai District, Beijing 100071, China
    Arch Virol 153:1175-9. 2008
    ..It is also the first to report breakpoints within the NS3 gene of dengue viruses...
  84. ncbi Molecular epidemiology of Mycobacterium abscessus infections in a subtropical chronic ventilatory setting
    Wei Chang Huang
    Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Med Microbiol 59:1203-11. 2010
    ..abscessus infections may have been spread by the movement of patients between RCWs, a routine practice in Taiwan's integrated delivery system...
  85. pmc Current molecular epidemiology of Lassa virus in Nigeria
    Deborah U Ehichioya
    Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria
    J Clin Microbiol 49:1157-61. 2011
    ..The Bayesian analysis also provided estimates for divergence times within the Lassa virus clade...
  86. pmc Molecular epidemiology of Panton-Valentine leukocidin-positive Staphylococcus aureus in Spain: emergence of the USA300 clone in an autochthonous population
    Raquel Blanco
    Clinical Microbiology and Infection Control Department, Basurto Hospital, Bilbao, Spain
    J Clin Microbiol 49:433-6. 2011
    ..For the first time, the USA300 clone is reported as predominant among PVL-positive clones in a European autochthonous population, requiring active monitoring of the incidence of USA300 in Spain and throughout Europe...
  87. pmc Molecular epidemiology of vancomycin-resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals
    Diana Panesso
    Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia
    J Clin Microbiol 48:1562-9. 2010
    ..The overwhelming presence of plasmids encoding putative virulence factors and vanA genes suggests that E. faecium from the CC17 genogroup may disseminate in the region in the coming years...
  88. pmc Wide dispersion of ST175 clone despite high genetic diversity of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical strains in 16 Spanish hospitals
    María García-Castillo
    Servicio de Microbiologia, Hospital Universitario Ramon y Cajal, Ctra Colmenar Km 9 1, 28034 Madrid, Spain
    J Clin Microbiol 49:2905-10. 2011
    ..aeruginosa clones at high risk for epidemic spread, such as the Liverpool, Manchester, and Melbourne clones previously found in cystic fibrosis patients and ST235 in the nosocomial setting...
  89. pmc Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:3849-54. 2011
    Acinetobacter baumannii is emerging as an important nosocomial pathogen worldwide. We report molecular epidemiology of 65 carbapenem-nonsusceptible A...
  90. ncbi Faecal carriage of extended-spectrum beta-lactamase-producing Escherichia coli: prevalence, risk factors and molecular epidemiology
    Jesús Rodríguez-Baño
    Seccion de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain
    J Antimicrob Chemother 62:1142-9. 2008
    ..The aim of this study was to investigate the epidemiology of faecal carriage of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in the community...
  91. ncbi The emergence and evolution of methicillin-resistant Staphylococcus aureus
    K Hiramatsu
    Department of Bacteriology, Juntendo University, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Trends Microbiol 9:486-93. 2001
    ..aureus strains from the normal human flora into MRSA...
  92. pmc Molecular epidemiology of domestic and sylvatic Trypanosoma cruzi infection in rural northwestern Argentina
    Marta V Cardinal
    Laboratorio de Eco Epidemiología, Departamento de Ecologia, Genetica y Evolucion, Universidad de Buenos Aires, Buenos Aires, Argentina
    Int J Parasitol 38:1533-43. 2008
    ..cruzi. We believe that in Argentina, this is the first time that lineage IIc has been isolated from naturally infected domestic dogs and Tr. infestans...
  93. ncbi Molecular epidemiology of tuberculosis in England, 1998
    J Love
    Respiratory Diseases Department, Health Protection Agency HPA Centre for Infections, London, UK
    Int J Tuberc Lung Dis 13:201-7. 2009
  94. ncbi Molecular epidemiology and interferon susceptibility of the natural recombinant hepatitis C virus strain RF1_2k/1b
    Fuat Kurbanov
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 198:1448-56. 2008
    ..Currently, there are no data available on the molecular epidemiology and interferon susceptibility of the natural intergenotypic recombinant RF1_2k/1b (RF1) strain.
  95. ncbi Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong
    Susanna K P Lau
    State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
    J Infect Dis 196:986-93. 2007
    ..We conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (NPAs) and fecal samples...
  96. pmc High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children
    Kathryn E Holt
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    BMC Infect Dis 10:144. 2010
    ..Kathmandu, the capital of Nepal, is an area of high incidence and the pediatric population appears to be at high risk of exposure and infection...
  97. ncbi Molecular epidemiology of Cryptosporidium in humans and cattle in The Netherlands
    Peter R Wielinga
    National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, Laboratory for Zoonoses and Environmental Microbiology LZO, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Int J Parasitol 38:809-17. 2008
    ..hominis IbA10G2 is found at high frequencies in autumn in humans and not in cattle. The high prevalence of C. parvum IIaA15G2R1 in both humans and cattle indicates that cattle may be a reservoir for this sub-type in The Netherlands...
  98. pmc Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983-2005
    Seok Min Yun
    WHO Japanese Encephalitis Regional Reference Laboratory for the Western Pacific Region Division of Arboviruses, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea
    Virol J 7:127. 2010
    ..The two genotypes were detected simultaneously in 1994 but since then, only genotype 1 has been isolated in South Korea. Thus, the genotype change occurred according to the year of isolation rather than the geographical origin...
  99. ncbi Molecular and spatial epidemiology of human campylobacteriosis: source association and genotype-related risk factors
    P Mullner
    Molecular Epidemiology and Veterinary Public Health Laboratory, Hopkirk Research Institute, Massey University, Palmerston North, New Zealand
    Epidemiol Infect 138:1372-83. 2010
    ..In particular young children in rural areas had a higher risk of infection with ruminant strains than their urban counterparts. These findings provide important information for the implementation of pathway-specific control strategies...
  100. pmc Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China
    Ying Ma
    CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing 100101, The People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 364:2725-37. 2009
    ..All of these pathogens occur in Southeast Asia, including China, with severe consequences; therefore, we discuss the issues in this article by addressing the situation of the zoonotic threat in China...
  101. ncbi Pattern and molecular epidemiology of Hepatitis B virus genotypes circulating in Pakistan
    Zunaira Awan
    Division of Molecular Virology, National Centre of Excellence in Molecular Biology, 87 West Canal Bank Road, Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan
    Infect Genet Evol 10:1242-6. 2010
    ..Overall Genotype C is the most prevalent genotype. Genotypes B and C are predominant in Punjab & Balochistan and Khyber Pakhtoonkhwa, respectively whereas genotype A in Sindh...

Research Grants75

  1. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    ..If breast cancer can be attributed, in part, to cigarette smoking, then smoking prevention or cessation should reduce exposure and thus decrease the incidence of breast cancer. ..
  2. Non-invasive zoonotic pathogen exposure and outcome biomarkers with follow-up in
    Christopher D Heaney; Fiscal Year: 2013
    ..My goal is to integrate my existing experience with focused training in microbiology, immunology, and the molecular epidemiology of zoonotic pathogens, to become an independent scientist at the interface of basic science, occupational ..
  3. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..Her mentors are nationally and internationally renowned experts in pediatric asthma and environmental and molecular epidemiology, and will provide full access to the resources accompanying two unique cohorts of endotoxin exposed ..
  4. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..The long- term goal of this study is to identify effective biomarkers that can be used to identify at-risk individuals who will be targeted for primary prevention and early detection of SCCHN in the general population. ..
  5. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    ..further training in immunology, hypoxemia and oxygen sensing, in vivo human metabolism, genetic and molecular epidemiology and longitudinal data analysis, with ongoing feedback from a formal Career Development Advisory Committee...
  6. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): My career goal is to become an established researcher in the molecular epidemiology of cancer...
  7. Molecular pathogenesis and genetic diversification of childhood falciparum malari
    STEVE MYER TAYLOR; Fiscal Year: 2013
    ..The candidate has extensive experience with clinical medicine, clinical epidemiology, and molecular epidemiology, and proposes to use these investigations of parasite virulence as a means to transition to a career in ..
  8. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    ..The North American Pancreatitis Study 2 (NAPS2) began in 2002 as a prospective molecular epidemiology study conducted at 20 expert pancreas centers across the US...
  9. Causes of rotavirus vaccine failure in Zambian children
    Roma Chilengi; Fiscal Year: 2013
    ..iii) Introduction of rotavirus vaccine will alter te molecular epidemiology of circulating rotavirus strains detected in vaccinated children presenting with severe diarrhea...
  10. The Role of Genetics in Innate Immunity Following Cholestasis
    Samuel M Alaish; Fiscal Year: 2011
    ..James Nataro M.D., Ph.D. will be his primary mentor;he is an expert on the pathogenesis, genomics, molecular epidemiology and diagnosis of enteroaggregative E. coli...
  11. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    ..on malaria field isolates from Yunnan and Hainan using genetic markers, thus enabling us to study the molecular epidemiology of these important malaria parasites in this proposal. The specific aims are to: 1...
  12. Molecular Epidemiology of the Vaginal Microbiome
    Rebecca M Brotman; Fiscal Year: 2013
    ..This research will contribute valuable information on the causes of BV, help develop improved methods for diagnosing, preventing and treating BV, and may help reduce major reproductive health problems associated with BV. ..
  13. Melanoma Prevention: Using the Sun
    Marianne Berwick; Fiscal Year: 2013
    ..Dr. Berwick's wide experience in population-based investigations and molecular epidemiology will facilitate these new studies...
  14. Pilot studies of the molecular epidemiology of drug-resistant malaria in Myanmar
    Christopher V Plowe; Fiscal Year: 2013
    ..This work is expected to contribute to the development of robust surveillance tools that can be used to track and contain artemisinin resistance in Southeast Asia and elsewhere. ..
  15. Vitamin D and Non-Hodgkin Lymphoma Prognosis
    Jennifer L Kelly; Fiscal Year: 2012 applicant): My long-term career goal is to become an independent investigator with the ability to apply molecular epidemiology methods, in the context of translational research, to gain better understanding of the factors and ..
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  17. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..To achieve these aims, we will use the Lymphoma Molecular Epidemiology Resource, an ongoing, prospective prognostic cohort study of newly diagnosed cases from the Mayo Clinic ..
  18. Suppressors of cytokine signaling (SOCS) in HAART-treated HIV infection
    Maria C Villacres; Fiscal Year: 2010
    ..This novel approach will combine the expertise of molecular epidemiology with cellular immunology and will advance our current understanding of HIV infection and effect of ..
  19. Molecular epidemiology of non-Hodgkin lymphoma prognosis and prevention
    Sophia Wang; Fiscal Year: 2013
    ..Public health relevance: successful completion of this study will contribute to the understanding of host genetic variation and tumor markers in NHL survival. ..
  20. Telomere dysfunction, chromosome 9 instability and bladder cancer risk
    Yun Ling Zheng; Fiscal Year: 2013
    ..We propose to conduct a molecular epidemiology study of bladder cancer, using the biological specimens and epidemiological data collected by an ongoing ..
  21. Risk of Leukemia after Protracted Exposures to Low Doses of Ionizing Radiation
    LYDIA BOGDANIVNA ZABLOTSKA; Fiscal Year: 2013 areas, including design and conduct of epidemiological studies, research methods in genetic and molecular epidemiology, advanced statistical training to analyze radiation-related risks and gene-environment interactions, and ..
  22. Vertical CMV transmission in the setting of maternal HIV-1 infection in Kenya
    JENNIFER ANN SLYKER; Fiscal Year: 2013
    ..combined with her rigorous background in immunology, will enable her to pursue a long-term career in molecular epidemiology focusing on women and children at risk for HIV. During the award period, Dr...
  23. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    ..We will use a standardized molecular epidemiology framework with custom made statistics and bioinformatics developed over the past 6 years by the Day ..
  24. Systems Biology for Molecular Analysis of Tuberculosis in Ethiopia
    Gobena Ameni; Fiscal Year: 2013
    ..b>Molecular epidemiology is gaining importance in tracking strains and addressing key public health challenges to prevent and ..
  25. Crossing Borders: HIV and Substance use at the Gateway to North America
    Kimberly C Brouwer; Fiscal Year: 2013
    ..of HIV, hepatitis C virus (HCV), and STIs among substance users;and 3) explore the phylo-geography and molecular epidemiology of HIV-1 infection in at-risk groups...
  26. HPV Disease in the Era of HPV Vaccines
    Laura A Koutsky; Fiscal Year: 2010
    ..research projects that will synergistically build on each other, and on our team's experience with molecular epidemiology studies of HPV infection and related precancerous lesions and cancers...
  27. Training in Molecular and Mechanistic Toxicology
    Edson X Albuquerque; Fiscal Year: 2012 to train graduate students and postdoctoral fellows in neurotoxicology, cell injury and carcinogenesis, molecular epidemiology and aquatic toxicology, with special emphasis on mechanisms and application of cutting-edge technologies ..
  28. SP-D as an immunomodulatory protein in acute rejection in lung transplantation
    KAREN D SIMS; Fiscal Year: 2010
    ..will also provide the candidate with valuable knowledge and skill in the fields of lung transplantation biology and molecular epidemiology, facilitating the candidate's development as an independent translational researcher.
  29. Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis infection
    Loris Y Hwang; Fiscal Year: 2012
    ..studies of natural HPV infection and has extensive experience in the evaluation of cervical maturity and molecular epidemiology studies of mucosal immunology. Her co-mentor, Richard S...
  30. Early Insulin Therapy and Development of ARDS
    Michelle Ng Gong; Fiscal Year: 2011
    ..therapy and development of ARDS will be examined in a retrospective nested case control study based on the Molecular Epidemiology of ARDS, a large prospective study of patients at risk for ARDS...
  31. Functional Vitamin D Receptor Gene Variants and Racial/Ethnic Cancer Disparities
    Robin Taylor Wilson; Fiscal Year: 2010
    ..This proposal is consistent with the NIH Road Map's call for interdisciplinary research teams and NCI priorities to reduce cancer disparities and advance molecular epidemiology.
  32. Malaria transmission potential of the Anopheles punctutatus species complex
    Lisa Reimer; Fiscal Year: 2013
    ..Mueller's lab over the last ten years to strengthen the molecular epidemiology program at PNGIMR and to establish training curricula for Fogarty International Center sponsored programs...
  33. Epigenetic Events and Colorectal Cancer Epidemiology
    Shuji Ogino; Fiscal Year: 2013
    ..provided by applicant): As the first independent application led by a recipient of NCI K07 Award ("Molecular Epidemiology of Colorectal Cancer"), this proposal addresses hypotheses in epigenetics and epidemiology of colorectal ..
  34. Epigenetic alterations in oral rinse as biomarkers of oral and pharyngeal cancer
    Scott M Langevin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The focus of my research is the molecular epidemiology of upper aerodigestive tract cancers;with a primary interest in the epigenetics of cancer, in particular DNA methylation, and its diagnostic and ..
  35. Chemokine-related acute lung injury pathogenesis in African-American patients
    Kirsten Neudoerffer Kangelaris; Fiscal Year: 2013
    ..Bradley Aouizerat, a leader in genomics and molecular epidemiology. Additionally, Dr. Kangelaris will benefit from the expertise of several scientific advisors...
  36. Molecular Epidemiology and Natural History of SIVcpz
    Beatrice H Hahn; Fiscal Year: 2013
    ..developed non-invasive (fecal and urine based) SIVcpz detection methods and used these to characterize the molecular epidemiology of SIVcpz in wild-living ape populations throughout equatorial Africa (Nature 2004;Science 2006)...
  37. PPAR gamma in pediatric sepsis and the inflammatory response in obesity
    JENNIFER MELISSA KAPLAN; Fiscal Year: 2013
    ..Division of Critical Care Medicine at Cincinnati Children's Hospital Medical Center with training in molecular epidemiology and sepsis-related basic science research...
  38. Targeted Infection Prevention (TIP) Program in Nursing Homes
    Lona Mody; Fiscal Year: 2013
    ..The proposed research will also provide novel insight into the molecular epidemiology and mechanisms of transmission of resistant pathogens...
  39. Bladder Cancer Prognostic Indicators
    Angeline Andrew; Fiscal Year: 2009
    ..This mentored molecular epidemiology research experience under the guidance of the epidemiologist, Dr...
  40. Molecular Epidemiology of Leprosy
    Varalakshmi D Vissa; Fiscal Year: 2010
    ..leprae. ..
  41. Genetic & Epigenetic Modifiers of Maternal-Fetal Transfer of Toxicants & Outcomes
    Adrienne S Ettinger; Fiscal Year: 2011
    ..of mentored research and additional training in scientific and laboratory methods relevant to genetic and molecular epidemiology. This will enable her to subsequently develop an independent, interdisciplinary research program with a ..
  42. Evaluation of HIV-1 Drug Resistance among Antiretroviral Treatment Naive and Expe
    Avelin Fobang Aghokeng; Fiscal Year: 2013
    ..for the purpose of viral load testing and drug resistance genotyping, (v) evaluate the current HIV-1 molecular epidemiology in Cameroon and finally (vi) assess programmatic factors potentially associated with the prevention or ..
  43. Molecular Epidemiology of Pediatric Germ Cell Tumors
    Jenny N Poynter; Fiscal Year: 2013
    ..In addition, understanding methylation patterns in pediatric GCTs may indicate the developmental stage at which the tumor arose. ..
  44. Molecular Epidemiology of NHL and CLL
    James R Cerhan; Fiscal Year: 2012
  45. Immune dysfunction associated with early life heavy metal exposure
    EMILY CATHERINE SOMERS; Fiscal Year: 2013 acquiring comprehensive training in relevant areas in environmental health sciences, including molecular epidemiology, immunotoxicology, and epigenetics...
  46. The molecular basis of epidemic blaKPC Klebsiella pneumoniae and Enterobacteriace
    BARRY NEAL KREISWIRTH; Fiscal Year: 2010
    ..We will prospectively characterize the nature and extent of the KPC epidemic to examine the molecular epidemiology of infecting isolates over the 5-year project period, including other emerging carbapenem-resistant ..
  47. Incidence and Natural History of Hepatitis E Virus in Pregnant Bangladeshi Women
    ALAIN BERNARD LABRIQUE; Fiscal Year: 2010
    ..We will also isolate and sequence HEV from acutely ill women, for insight into the molecular epidemiology of HEV...
  48. Recurrent MRSA Infections: A Study of Risk Factors and Molecular Epidemiology
    MICHAEL ZDENEK DAVID; Fiscal Year: 2013
  49. Acute Kidney Failure in a Cancer ICU
    Joshua A Samuels; Fiscal Year: 2010 the UT-Houston School of Public Health, a period of laboratory training to gain facility with molecular epidemiology, and structured mentoring from two highly successful investigators...
  50. Epidemic CA-MRSA: Molecular Epidemiology and Immunology
    Robert S Daum; Fiscal Year: 2013
    ..It is hoped that new information will guide novel therapeutic and preventive strategies to combat CA-MRSA infection. ..
  51. The Recombinase FimX: Role in type 1 pili regulation and E. coli-induced cystitis
    Patrick C Seed; Fiscal Year: 2010
    ..coli urinary tract infections. In Aim 1 of this proposal, we will use a combination of molecular epidemiology, genetics, and animal modeling to characterize the prevalence of fimX and study the in vivo role of FimX ..
  52. Molecular Markers of Risk, Phenotype, and Outcomes in ARDS
    Ednan K Bajwa; Fiscal Year: 2012
    ..Ednan Khalid Bajwa for an academic career in molecular epidemiology and ARDS risk and outcomes. Dr...
  53. The molecular basis of the epidemic blaKPC gene Klebsiella
    BARRY NEAL KREISWIRTH; Fiscal Year: 2013
    ..and extent of the KPC epidemic in two consecutive cross-sectional studies (years 1 and 4) to examine the molecular epidemiology of infecting isolates over the 5-year project period, including other emerging carbapenem-resistant ..
  54. Molecular Antibiotic Resistance Arrays for clinical microbiology laboratories
    PAUL STEPHEN KEIM; Fiscal Year: 2013
    ..The project team has expertise from translational research, genomic analysis, clinical-based research, molecular epidemiology, public health and medical biotechnology development...
  55. A Molecular-Social Network Investigation of HIV-HCV Co-infection in Chinese MSM
    Frank Y Wong; Fiscal Year: 2013
    ..IDU to HCV transmission among HIV-infected Chinese MSM and their IDU and sexual partners;(2) establish the molecular epidemiology of HCV and HIV (via genotyping and phylogenetic analysis);describe and examine biosocial correlates (e.g...
  56. Targeted Therapy for Burkitt Lymphoma in Resource Poor Settings
    Glen N Barber; Fiscal Year: 2010
    ..In order to investigate this we will investigate the molecular epidemiology and pathogenesis of primary tumors and prospectively analyze lymphomas derived from patients with EBV+ ..
  57. Clostridium difficile Cooperative Research Center
    Vincent B Young; Fiscal Year: 2013
    ..will be used to develop a rapid single-nucleotide polymorphism typing scheme to aid in rapid diagnosis and molecular epidemiology. The second project will utilize the clinical specimens and clinical strains to determine the role of the ..
  58. Epidemiology of rural MRSA: is livestock contact a risk factor?
    Margaret L Chorazy; Fiscal Year: 2012
    ..strains, and the frequency with which these cause symptomatic infection in our cohorts;and determined the molecular epidemiology of MRSA strains causing symptomatic infections in Iowa...
  59. Molecular Epidemiology of Pancreatic Cancer
    Paige M Bracci; Fiscal Year: 2010
    ..Blood will be collected from eligible participants. UCSF's Molecular Epidemiology Core will process all bloods and extract DMA for use in molecular/ genetic studies...
  60. HIV-1 and Protective Immunity against Common Childhood Pathogens
    Carey Farquhar; Fiscal Year: 2013
    ..for students in the UW Department of Epidemiology, all of whom are actively involved in clinical or molecular epidemiology projects based in Nairobi...
  61. Conotruncal defects: genetic and nutritional risk
    EDWARD JAMES LAMMER; Fiscal Year: 2010
    ..The research capitalizes on the investigators'collective expertise in molecular epidemiology, nutritional epidemiology, clinical and molecular genetics, and teratogenesis...
  62. Global and Specific Oxidation Pathways Related to Prostate Cancer, Prospective an
    Tianying Wu; Fiscal Year: 2013
    ..academic background, with a PhD in nutrition biochemistry and postdoctoral training in nutrition and molecular epidemiology at the Harvard School of Public Health, where she also earned a master's degree in epidemiology...
  63. Implementing genomic medicine in clinical care of deaf patients
    Xue Z Liu; Fiscal Year: 2013
    ..families derived from three unique sources from USA, China and Turkey, suitable for determination of molecular epidemiology of hereditary deafness and for new gene identification...
    Alan Barrett; Fiscal Year: 2000
  65. Molecular Epidemiology of Secondary Lung Cancer
    Peter Shields; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
    Jeanne Manson; Fiscal Year: 2001
    ..formal training and research experience necessary for her development as an independent investigator in Molecular Epidemiology of Birth Defects...
    Qingyi Wei; Fiscal Year: 2000
    ..The long-term goal of this study is to identify susceptibility markers for the assessment of CMM risk and to identify individuals at high risk of CMM for future cancer-prevention programs. ..
    Otoniel Martinez Maza; Fiscal Year: 2004
    ..In this proposal, studies are presented to elucidate the molecular epidemiology of AIDS-lymphoma...
  69. Molecular epidemiology of sulfadoxine-pyrimethamine
    Thomas Egwang; Fiscal Year: 2006
    ..The long-term objective is to provide scientific data on the molecular epidemiology of SP resistance over the next three years of CQ/SP coverage for an evidence-based re-evaluation of this ..
    Chester Douglass; Fiscal Year: 2007
    ..This competing renewal proposal plans to provide integrated training in three focus areas: molecular epidemiology of oral diseases, epidemiology of oral and systemic diseases, and evidence-based dentistry...
  71. Molecular Epidemiology of Recurrent Aphthous Stomatitis: Role of Ghrelin
    Lorena Baccaglini; Fiscal Year: 2009
    ..In particular, we are interested in knowing if patients with canker sores have a deficit of ghrelin (a newly discovered hormone involved in growth and mucosal protection from injury). ..
    Philip Hanawalt; Fiscal Year: 2000
    This project is concerned with the molecular epidemiology of cancer, beginning with the realization that as many as half a dozen independent genetic and epigenetic events may be involved in the transformation from a normal cell to ..
    Harvey Checkoway; Fiscal Year: 2006
    DESCRIPTION (Provided by Applicant) This application is for a renewal of training grant: "Environmental and Molecular Epidemiology" that originally was established in 1990...
  74. Molecular Epidemiology of Dilated Cardiomyopath
    Luisa Mestroni; Fiscal Year: 2005
    This proposal addresses the molecular epidemiology of dilated cardiomyopathy by determining the frequency of disease gene mutations, and the genotype/phenotype correlations in the patient population, and their clinical relevance...
  75. Molecular Epidemiology of Cryptosporidiosis in India
    Honorine Ward; Fiscal Year: 2007
    ..The overall goal of studies on cryptosporidiosis in CMC, Vellore is to investigate the molecular epidemiology of cryptosporidiosis and the human immune response to Cryptosporidium spp...