meta analysis

Summary

Summary: A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.

Top Publications

  1. ncbi Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes
    Jonathan J Deeks
    Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, UK
    Stat Med 21:1575-600. 2002
  2. ncbi To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data
    Lesley A Stewart
    Eval Health Prof 25:76-97. 2002
  3. ncbi Antipsychotic-induced tardive dyskinesia and the Ser9Gly polymorphism in the DRD3 gene: a meta analysis
    P Roberto Bakker
    Psychiatric Hospital Symfora Group, Amersfoort, The Netherlands
    Schizophr Res 83:185-92. 2006
  4. ncbi Exploring sources of heterogeneity in systematic reviews of diagnostic tests
    Jeroen G Lijmer
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, The Netherlands
    Stat Med 21:1525-37. 2002
  5. ncbi Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles
    An Wen Chan
    Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford, England
    JAMA 291:2457-65. 2004
  6. ncbi Should meta-analysts search Embase in addition to Medline?
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    J Clin Epidemiol 56:943-55. 2003
  7. ncbi Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches
    Pamela Royle
    Wessex Institute for Health Research and Development
    Int J Technol Assess Health Care 19:591-603. 2003
  8. pmc Conducting systematic reviews of diagnostic studies: didactic guidelines
    Walter L Deville
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Med Res Methodol 2:9. 2002
  9. ncbi A comparison of the quality of Cochrane reviews and systematic reviews published in paper-based journals
    Beverley Shea
    Institute of Population Health, University of Ottawa
    Eval Health Prof 25:116-29. 2002
  10. ncbi A unification of models for meta-analysis of diagnostic accuracy studies
    Roger M Harbord
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Biostatistics 8:239-51. 2007

Detail Information

Publications264 found, 100 shown here

  1. ncbi Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes
    Jonathan J Deeks
    Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, UK
    Stat Med 21:1575-600. 2002
    ..The appropriate selection for a particular meta-analysis may depend on understanding reasons for variation in control group event rates; in some situations uncertainty about the choice of summary statistic will remain...
  2. ncbi To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data
    Lesley A Stewart
    Eval Health Prof 25:76-97. 2002
    ....
  3. ncbi Antipsychotic-induced tardive dyskinesia and the Ser9Gly polymorphism in the DRD3 gene: a meta analysis
    P Roberto Bakker
    Psychiatric Hospital Symfora Group, Amersfoort, The Netherlands
    Schizophr Res 83:185-92. 2006
    ....
  4. ncbi Exploring sources of heterogeneity in systematic reviews of diagnostic tests
    Jeroen G Lijmer
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, The Netherlands
    Stat Med 21:1525-37. 2002
    ..Results of such analyses will help understand problems with the transferability of diagnostic tests and to point out flaws in primary studies. As such, they can guide the design of future studies...
  5. ncbi Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles
    An Wen Chan
    Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford, England
    JAMA 291:2457-65. 2004
    ..Selective reporting of outcomes within published studies based on the nature or direction of their results has been widely suspected, but direct evidence of such bias is currently limited to case reports...
  6. ncbi Should meta-analysts search Embase in addition to Medline?
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada
    J Clin Epidemiol 56:943-55. 2003
    ..88-0.99). Searching Medline but not Embase risks biasing a meta-analysis by finding studies that show larger estimates, but their prevalence seems low enough that the risk may be slight, provided the rest of the search is comprehensive...
  7. ncbi Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches
    Pamela Royle
    Wessex Institute for Health Research and Development
    Int J Technol Assess Health Care 19:591-603. 2003
    ..To analyze sources searched in Cochrane reviews, to determine the proportion of trials included in reviews that are indexed in major databases, and to compare the quality of these trials with those from other sources...
  8. pmc Conducting systematic reviews of diagnostic studies: didactic guidelines
    Walter L Deville
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Med Res Methodol 2:9. 2002
    ..Although guidelines for critical appraisal of diagnostic research and meta-analyses have already been published, these may be difficult to understand for clinical researchers or do not provide enough detailed information...
  9. ncbi A comparison of the quality of Cochrane reviews and systematic reviews published in paper-based journals
    Beverley Shea
    Institute of Population Health, University of Ottawa
    Eval Health Prof 25:116-29. 2002
    ..In addition, the use of evidence-based criteria (i.e., the QUOROM statement) for reporting systematic reviews may help further to improve their quality...
  10. ncbi A unification of models for meta-analysis of diagnostic accuracy studies
    Roger M Harbord
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Biostatistics 8:239-51. 2007
    ..We discuss the different forms of summary model output suggested by the two approaches, including summary ROC curves, summary points, confidence regions, and prediction regions...
  11. ncbi Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
    Johannes B Reitsma
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Epidemiol 58:982-90. 2005
    ..Studies of diagnostic accuracy most often report pairs of sensitivity and specificity. We demonstrate the advantage of using bivariate meta-regression models to analyze such data...
  12. pmc Estimating the mean and variance from the median, range, and the size of a sample
    Stela Pudar Hozo
    Department of Mathematics, Indiana University Northwest, Gary, IN 46408, USA
    BMC Med Res Methodol 5:13. 2005
    ..However, sometimes the published reports of clinical trials only report the median, range and the size of the trial...
  13. ncbi Storylines of research in diffusion of innovation: a meta-narrative approach to systematic review
    Trisha Greenhalgh
    Department of Primary Care and Population Sciences, University College London, London N19 5LW, UK
    Soc Sci Med 61:417-30. 2005
    ..Its contribution to the mixed economy of methods for the systematic review of complex evidence should be explored further...
  14. ncbi Combining multiple outcome measures in a meta-analysis: an application
    Lidia R Arends
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Stat Med 22:1335-53. 2003
    ..It turns out that the general linear MIXED model is a very convenient framework for multivariate meta-analysis. All analyses could be carried out in standard general linear MIXED model software...
  15. ncbi Searching one or two databases was insufficient for meta-analysis of observational studies
    Adina R Lemeshow
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    J Clin Epidemiol 58:867-73. 2005
    ..To address methodologic issues in searching for observational studies by presenting database search methods and results...
  16. pmc Assessing harmful effects in systematic reviews
    Heather M McIntosh
    Centre for Reviews and Dissemination, University of York, UK
    BMC Med Res Methodol 4:19. 2004
    ..We present our own recent experience of conducting systematic reviews of harmful effects and make suggestions for future practice and further research...
  17. ncbi Using meta ethnography to synthesise qualitative research: a worked example
    Nicky Britten
    Department of General Practice and Primary Care, King s College London, 5 Lambeth Walk, London SE11 6SP, UK
    J Health Serv Res Policy 7:209-15. 2002
    ..To demonstrate the benefits of applying meta ethnography to the synthesis of qualitative research, by means of a worked example...
  18. ncbi Bayesian random effects meta-analysis of trials with binary outcomes: methods for the absolute risk difference and relative risk scales
    D E Warn
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 21:1601-23. 2002
    ..The advantages and flexibility of a fully Bayesian approach to meta-analysis of binary outcome data, considered on an absolute risk or relative risk scale, are now available...
  19. ncbi An evaluation of bivariate random-effects meta-analysis for the joint synthesis of two correlated outcomes
    R D Riley
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK
    Stat Med 26:78-97. 2007
    ..Bivariate meta-regression and further research priorities are also discussed...
  20. ncbi Synthesising qualitative and quantitative evidence: a review of possible methods
    Mary Dixon-Woods
    Department of Health Sciences, University of Leicester, LE1 6TP Leicester, UK
    J Health Serv Res Policy 10:45-53. 2005
    ..There is an urgent need for robust ways of incorporating qualitative evidence into systematic reviews...
  21. pmc Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice
    R Andrew Moore
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Musculoskelet Disord 7:79. 2006
    ....
  22. ncbi Epidemiology, treatment and chemoprevention in colorectal cancer
    P Rougier
    Hospital Ambroise Pare, Boulogne Billancourt, France
    Ann Oncol 14:ii3-5. 2003
    ..Much CRC is familial, raising the prospect of targeted screening to aid early detection. Since the molecular events leading to CRC have become better characterized, there is also the possibility of developing chemoprotective agents...
  23. pmc Identifying null meta-analyses that are ripe for updating
    Nicholas J Barrowman
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    BMC Med Res Methodol 3:13. 2003
    ..As an increasingly large number of meta-analyses are published, quantitative methods are needed to help clinicians and systematic review teams determine when meta-analyses are not up to date...
  24. pmc A comparison of three different sources of data in assessing the frequencies of adverse reactions to amiodarone
    Yoon K Loke
    Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Br J Clin Pharmacol 57:616-21. 2004
    ....
  25. ncbi Generalized least squares for the synthesis of correlated information
    A Berrington
    Cancer Research UK Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, UK
    Biostatistics 4:423-31. 2003
    ..We then illustrate the method with several examples from an analysis in which case-control studies of cervical cancer and oral contraceptive use are synthesized...
  26. ncbi Four-fold table cell frequencies imputation in meta analysis
    Carlo Di Pietrantonj
    Servizio Regionale di Epidemiologia ASL 20, Via Venezia 6, 15100 Alessandria, Italia
    Stat Med 25:2299-322. 2006
    b>Meta analysis is a collection of quantitative methods devoted to combine summary information from related but independent studies...
  27. ncbi Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials
    John P A Ioannidis
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Clin Epidemiol 58:543-9. 2005
    ..We hypothesized that controversial data are attractive to investigators and editors, and thus the most extreme, opposite results would appear very early rather than late, as data accumulate, provided data can be generated rapidly...
  28. ncbi Genetic associations: false or true?
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Trends Mol Med 9:135-8. 2003
    ..However, a sizeable proportion of identified genetic associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative synthesis of all the available data, might help us to separate the true from the false...
  29. pmc Combining Affymetrix microarray results
    John R Stevens
    Department of Statistics, Purdue University, 150 N, University Street, West Lafayette, Indiana 47907 2067, USA
    BMC Bioinformatics 6:57. 2005
    ..Although the experimental specifics are similar, typically a different list of statistically significant genes result from each data analysis...
  30. ncbi Multivariate meta-analysis
    In Sun Nam
    Queensland University of Technology, Australia
    Stat Med 22:2309-33. 2003
    ..Our preferred method is then illustrated through an analysis of a new data set on parental smoking and two health outcomes (asthma and lower respiratory disease) in children...
  31. pmc Evaluating meta-analyses in the general surgical literature: a critical appraisal
    Elijah Dixon
    Department of Surgery, University of Calgary, Calgary, Alberta, Canada
    Ann Surg 241:450-9. 2005
    ..To assess the methodologic quality of meta-analyses of general surgery topics published in peer-reviewed journals...
  32. ncbi Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach
    John R Thompson
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, 22 28 Princess Rd West, Leicester, LE1 6TP, U K
    Stat Med 24:2241-54. 2005
    ..We show how either maximum likelihood or a Bayesian approach with vague prior distributions can be used to fit the alternative model...
  33. ncbi What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data
    Michael J Sweeting
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 23:1351-75. 2004
    ..To compare the performance of different meta-analysis methods for pooling odds ratios when applied to sparse event data with emphasis on the use of continuity corrections...
  34. ncbi The typical Cochrane review. How many trials? How many participants?
    Susan Mallett
    Int J Technol Assess Health Care 18:820-3. 2002
    ..To describe the number of trials and participants in a typical systematic review from The Cochrane Database of Systematic Reviews...
  35. ncbi A network of investigator networks in human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:302-4. 2005
    ....
  36. ncbi Assessing surrogates as trial endpoints using mixed models
    Edward L Korn
    Biometric Research Branch, EPN 8128, National Cancer Institute, Bethesda, MD 20892, USA
    Stat Med 24:163-82. 2005
    ..Graphical displays are also suggested. Two sets of trial results previously analysed for trial-level surrogacy are used as examples...
  37. pmc Reducing workload in systematic review preparation using automated citation classification
    A M Cohen
    Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Mail Code BICC, Portland, OR 97239 3098, USA
    J Am Med Inform Assoc 13:206-19. 2006
    ..To determine whether automated classification of document citations can be useful in reducing the time spent by experts reviewing journal articles for inclusion in updating systematic reviews of drug class efficacy for treatment of disease...
  38. ncbi Integrative analysis of the cancer transcriptome
    Daniel R Rhodes
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Genet 37:S31-7. 2005
    ..Here we discuss several such integrative computational and analytical approaches, including meta-analysis, functional enrichment analysis, interactome analysis, transcriptional network analysis and integrative model system analysis...
  39. pmc How does study quality affect the results of a diagnostic meta-analysis?
    Marie E Westwood
    Centre for Reviews and Dissemination, University of York, UK
    BMC Med Res Methodol 5:20. 2005
    ..A secondary objective was to contribute to the evaluation of QUADAS, an evidence-based tool for the assessment of quality in diagnostic accuracy studies...
  40. pmc Reporting of measures of accuracy in systematic reviews of diagnostic literature
    Honest Honest
    Academic Dept, of Obstetrics and Gynaecology, Birmingham Women s Hospital, Birmingham B15 2TG, United Kingdom
    BMC Health Serv Res 2:4. 2002
    ..Therefore, we performed this study to assess the measures of accuracy used for reporting results of primary studies as well as their meta-analysis in systematic reviews of test accuracy studies...
  41. ncbi Sensitivity analyses allowed more appropriate and reliable meta-analysis conclusions for multiple outcomes when missing data was present
    Richard D Riley
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Princess Road West, Leicester LE1 6TP, United Kingdom
    J Clin Epidemiol 57:911-24. 2004
    ..Dissemination bias, in how and what outcomes are reported or published, may be causing this incompleteness. This article illustrates these problems and presents possible sensitivity analyses to allow the most reliable conclusions...
  42. ncbi Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 156:300-10. 2002
    ....
  43. pmc Meta-analysis of genetic-linkage analysis of quantitative-trait loci
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Hum Genet 71:56-65. 2002
    ..The approach can be applied under other conditions, provided that the various studies use the same linkage statistic...
  44. ncbi A note on the genome scan meta-analysis statistic
    J A Koziol
    Biomathematics Division, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Ann Hum Genet 68:376-80. 2004
    ..We provide an alternative derivation of the null distribution of the GSMA statistic, with extensions, and we suggest approximations to the distribution of the GSMA statistic that may be useful in applications...
  45. ncbi Investigating cardiovascular risk reduction--the Rosuvastatin GALAXY Programme
    Herbert Schuster
    Humboldt University, Berlin, Germany
    Expert Opin Pharmacother 5:1187-200. 2004
    ..Ultimately, the GALAXY Programme will provide clinical data that will enable physicians to make more effective statin treatment decisions, which will lead to improved patient care and cardiovascular outcomes...
  46. ncbi Repeated-measures modeling improved comparison of diagnostic tests in meta-analysis of dependent studies
    Mir Said Siadaty
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Box 800717, Charlottesville, VA 22908, USA
    J Clin Epidemiol 57:698-711. 2004
    ..We adopt statistical methodology for repeated measurements for the purpose of meta-analysis of diagnostic tests...
  47. pmc Room for improvement? A survey of the methods used in systematic reviews of adverse effects
    Su Golder
    Centre for Reviews and Dissemination, University of York, York, YO10 5DD, UK
    BMC Med Res Methodol 6:3. 2006
    ..Although the methods for conducting systematic reviews of efficacy are well established, there is much less guidance on how systematic reviews of adverse effects should be performed...
  48. ncbi Advanced methods in meta-analysis: multivariate approach and meta-regression
    Hans C van Houwelingen
    Department of Medical Statistics, Leiden University Medical Center, P O Box 9604, 2300 RC Leiden, The Netherlands
    Stat Med 21:589-624. 2002
    ..All analyses that use approximate likelihood can be carried out by standard software. We demonstrate how the models can be fitted using SAS Proc Mixed...
  49. ncbi A comparison of the results of checked versus unchecked individual patient data meta-analyses
    Sarah Burdett
    Int J Technol Assess Health Care 18:619-24. 2002
    ..We therefore aimed to assess the utility of data checking by investigating whether checks made any appreciable difference to the results of an individual patient data meta-analysis...
  50. ncbi Individual patient- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head
    Jesse A Berlin
    University of Pennsylvania School of Medicine, Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Philadelphia, PA 19104 6021, USA
    Stat Med 21:371-87. 2002
    ..We recommend using individual patient data, when feasible, to study patient characteristics, in order to avoid the potential for ecological bias introduced by group-level analyses...
  51. ncbi Manual versus powered toothbrushes: a summary of the Cochrane Oral Health Group's Systematic Review. Part II
    Jane L Forrest
    Division of Health Promotion, Disease Prevention and Epidemiology, University of Southern California School of Dentistry, USA
    J Dent Hyg 78:349-54. 2004
    ....
  52. ncbi Evidence-based practice in radiology: steps 3 and 4--appraise and apply systematic reviews and meta-analyses
    Steve Halligan
    Department of Specialist Radiology, University College Hospital, Podium Level 2, 235 Euston Rd, London NW1 2BU, England
    Radiology 243:13-27. 2007
    ..They also explain how systematic review can help guide methodologic development for future research...
  53. ncbi Individual patient data meta-analyses
    Michael J Clarke
    Clinical Trial Service Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Best Pract Res Clin Obstet Gynaecol 19:47-55. 2005
    ..This chapter discusses the rationale for individual patient data reviews and describes some of their features...
  54. ncbi Evidence-based pharmacotherapy of obsessive-compulsive disorder
    Naomi A Fineberg
    Department of Psychiatry, Queen Elizabeth II Hospital, Welwyn Garden City, UK
    Int J Neuropsychopharmacol 8:107-29. 2005
    ..This paper reviews the key questions related to OCD pharmacotherapy, synthesizing evidence derived from randomized controlled trials, meta-analyses and consensus guidelines...
  55. ncbi Evidence-based treatment of haemophilia
    P H B Bolton-Maggs
    Department of Clinical Haematology, Manchester Royal Infirmary, Manchester M13 9WL, UK
    Haemophilia 10:20-4. 2004
    ..Cochrane methodology can be applied to haemophilia, and an assessment of prophylaxis provides an example. International collaborative studies would be valuable and require enthusiastic participants...
  56. ncbi Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2 sR, UK
    Lancet 365:341-6. 2005
    ..Also, although meta-analyses generally summarise an intervention's effect as a relative risk reduction, the groups of patients with the greatest absolute risk reduction have the most to gain...
  57. ncbi Imputing response rates from means and standard deviations in meta-analyses
    Toshi A Furukawa
    Department of Psychiatry, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya, Japan
    Int Clin Psychopharmacol 20:49-52. 2005
    ..This would allow a more robust and clinically interpretable estimation of the true, underlying treatment effect to be made...
  58. ncbi Investigating patient exclusion bias in meta-analysis
    Jayne F Tierney
    Meta analysis Group, MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Int J Epidemiol 34:79-87. 2005
    ..Trial investigators frequently exclude patients from trial analyses which may bias estimates of the effect of treatment. Combining these estimates in a meta-analysis could aggregate any such biases...
  59. ncbi Large trials or meta-analysis? That is not the question
    Jose Villar
    UNDP UNFPA WHO World Bank, Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    Best Pract Res Clin Obstet Gynaecol 19:27-35. 2005
    ..Heterogeneity of trial results should be evaluated, interactions and specific populations identified for the planning of the new large trial...
  60. ncbi Evidence-based practice in oral and maxillofacial surgery: audit of 1 training center
    Sze Lok Lau
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China
    J Oral Maxillofac Surg 65:651-7. 2007
    ..To evaluate the proportion of evidence-based interventions in the field of oral and maxillofacial surgery in a regional training center...
  61. ncbi Using systematic reviews for evidence-based health promotion: basic methodology issues
    Jefferson A Buendía-Rodriguez
    UNISALUD
    Rev Salud Publica (Bogota) 8:94-105. 2006
    ....
  62. ncbi Systematic reviews and their application to research in speech and language therapy: a response to T. R. Pring's 'Ask a silly question: two decades of troublesome trials' (2004)
    Zoe Garrett
    Social Science Research Unit, Institute of Education, London, UK
    Int J Lang Commun Disord 41:95-105. 2006
    ..This, it is argued, is most likely to demonstrate statistically significant effects and also help to ensure that therapies become sufficiently defined so that clinicians can apply them in practice...
  63. ncbi Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology
    Alistair Burns
    University of Manchester, Manchester, UK
    J Psychopharmacol 20:732-55. 2006
    ..Patients, their carers, and clinicians deserve to be optimistic in a field which often attracts therapeutic nihilism...
  64. ncbi The influence of display and statistical factors on the interpretation of metaanalysis results by physicians
    Parminder S Raina
    Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Med Care 43:1242-9. 2005
    ..The objective of this study was to determine the extent to which various factors affect the interpretation of metaanalytic results by physicians...
  65. ncbi Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis
    John Distler
    Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, Maryland, USA
    J Am Acad Nurse Pract 18:487-93. 2006
    ..To evaluate past and current evidence from randomized controlled trials on the efficacy of glucosamine sulfate (GS), glucosamine hydrochloride (GH), and chondroitin sulfate (CS) for the treatment of osteoarthritis (OA)...
  66. ncbi Systematic reviews of surgical interventions
    Martin Burton
    Department of Otolaryngology Head and Neck Surgery, University of Oxford, The Radcliffe Infirmary, Oxford OX2 6HE, England, UK
    Surg Clin North Am 86:101-14, ix. 2006
    ..They should be a prerequisite of any new research, a key component in decision making, and an opportunity for all surgical practitioners to get involved in the conduct and interpretation of research...
  67. ncbi Evidence-based medicine: what it is and what it is not
    Mohit Bhandari
    Division of Orthopaedic Surgery, McMaster University, Hamilton General Hospital, ON, Canada
    Injury 37:302-6. 2006
    ....
  68. ncbi Critical appraisal of the orthopaedic literature: therapeutic and economic analysis
    Jason W Busse
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont, Canada
    Injury 37:312-20. 2006
    ..Making this process explicit, with guidelines to assess the strength of the available evidence, will serve to improve patient care...
  69. pmc Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials?
    Rudolf W Poolman
    Department Surgery, Division of Orthopaedic Surgery, McMaster University, Hamilton General Hospital, 7 North, Room 727, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    BMC Med Res Methodol 6:44. 2006
    ..We aimed to determine the reporting quality of Randomised Controlled Trials (RCTs) published in the most frequently cited general orthopaedic journals...
  70. pmc Comparison of reports of randomized controlled trials and systematic reviews in surgical journals: literature review
    Sukhmeet Singh Panesar
    Department of Surgical Oncology and Technology, Imperial College London, UK
    J R Soc Med 99:470-2. 2006
    ..Two reviewers systematically and independently hand searched all issues of these journals over a 12-month period to identify randomised controlled trials and systematic reviews...
  71. ncbi Cautionary tales in the interpretation of systematic reviews of therapy trials
    I Scott
    Department of Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    Intern Med J 36:587-99. 2006
    ..Their strengths and limitations, and how their results can be subject to bias and misinterpretation, are discussed...
  72. pmc An alternative to the hand searching gold standard: validating methodological search filters using relative recall
    Margaret Sampson
    Chalmers Research Group, Children s Hospital of Eastern Ontario Research Institute, Canada
    BMC Med Res Methodol 6:33. 2006
    ..We demonstrate the feasibility of using relative recall of included studies from multiple systematic reviews to validate methodological search filters as an alternative to validation against a gold standard formed through hand searching...
  73. ncbi Scope for improvement in the quality of reporting of systematic reviews. From the Cochrane Musculoskeletal Group
    Beverley Shea
    EMGO Institute, Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    J Rheumatol 33:9-15. 2006
    ..To assess the quality of reporting in Cochrane musculoskeletal systematic reviews (excluding back and injury reviews)...
  74. ncbi Systematic reviews and meta-analyses in the Journal of Antimicrobial Chemotherapy
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 56:803-4. 2005
    ..In this article we outline the advantages and limitations inherent in these approaches, and the features that we look for when this type of article is submitted to JAC...
  75. ncbi Uncertainty method improved on best-worst case analysis in a binary meta-analysis
    Carrol Gamble
    Centre for Medical Statistics and Health Evaluation, Shelleys Cottage, University of Liverpool, Merseyside, UK
    J Clin Epidemiol 58:579-88. 2005
    ..This is not straightforward in practice: reviewers must decide how to handle missing outcome data in the contributing trials...
  76. ncbi Putting the practice into evidence-based dentistry
    Ian D Coulter
    Section of Public Health and Community Dentistry, University of California Los Angeles, School of Dentistry, 90095, USA
    J Calif Dent Assoc 35:45-9. 2007
    ..In this paper, it is argued that, for dentistry to enter into the brave new world of evidence-based practice, it will require some rethinking of the research enterprise in the profession...
  77. ncbi Meta-analyses and systematic reviews of psychological treatments for chronic pain: relevance to an evidence-based practice
    Beverly E Thorn
    Department of Psychology, University of Alabama, Tuscaloosa, AL 35487 0348, USA
    Health Psychol 26:10-2. 2007
    ..The article also highlights ways that practitioners and researchers can collaborate on treatment outcome research, thereby improving the ability to discover and disseminate effective treatments for patients who suffer from chronic pain...
  78. ncbi Summaries of findings, descriptions of interventions, and information about adverse effects would make reviews more informative
    Claire Glenton
    Norwegian Health Services Research Centre, Pb 7004 St Olavs Plass, 0130 Oslo, Norway
    J Clin Epidemiol 59:770-8. 2006
    ..To describe challenges when extracting and presenting relevant, consistent, and accessible information from systematic reviews...
  79. ncbi Indirect comparisons of competing interventions
    A M Glenny
    Cochrane Oral Health Group, Dental School, University of Manchester, UK
    Health Technol Assess 9:1-134, iii-iv. 2005
    ....
  80. ncbi Popular weight-loss diets: from evidence to practice
    Vasanti S Malik
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Nat Clin Pract Cardiovasc Med 4:34-41. 2007
    ..In this Review we discuss the current evidence on the efficacy of low-fat, low-carbohydrate and Mediterranean dietary patterns for weight loss, their potential mechanisms of action and important clinical considerations...
  81. ncbi [Methylphenidate in the treatment of attention-deficit/hyperactivity disorder: are we achieving an adequate clinical practice?]
    J Gonzalez de Dios
    Departamento de Pediatria, Hospital Universitario San Juan, 03550 San Juan, Espana
    Rev Neurol 43:705-14. 2006
    ..AIM. To analyze if the use of methylphenidate allows a good clinical practice in ADHD in terms of efficacy, effectiveness, efficiency and safety...
  82. ncbi Factorial design provides evidence to guide practice of anaesthesia
    K Korttila
    Department of Anaesthesia and Intensive Care, Helsinki University Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 49:927-9. 2005
    ....
  83. ncbi Systematic review as an evidence-based tool for the operating room
    Allyson Lipp
    School of Care Sciences, University of Glamorgan, Glyntaff, Pontypridd, United Kingdom
    AORN J 81:1279-82, 1285-7. 2005
    ....
  84. ncbi Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Toronto, Ontario, Canada
    J Clin Epidemiol 58:769-76. 2005
    ....
  85. ncbi Cochrane systematic reviews in acupuncture: methodological diversity in database searching
    Amit Sood
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Altern Complement Med 11:719-22. 2005
    ..Results from these trials have been synthesized in systematic reviews. A well-designed systematic review provides the highest level of evidence for establishing the efficacy of a clinical intervention...
  86. ncbi [Abecedary of the "Annales". Part 14]
    K Slim
    Service de Chirurgie Generale et Digestive, Hotel Dieu, Boulevard Leon Malfreyt, 63058 Clermont Ferrand, France
    Ann Chir 131:412-4. 2006
    ..The terms included and detailed in the present part are: Median, Medline, MeSH, meta-analysis, fixed effects model, random effects model, Mean...
  87. ncbi Research on homeopathy: state of the art
    Harald Walach
    University College Northampton, School of Social Sciences, UK
    J Altern Complement Med 11:813-29. 2005
    ..We close with some suggestions for potentially fruitful research...
  88. ncbi [Recent intervention studies with antihypertensive drugs and their influence on guidelines]
    Karl Heinz Rahn
    Medizinische Klinik und Poliklinik D, Universitatsklinikum, Muenster
    Med Klin (Munich) 98:771-5. 2003
    ..Both groups of experts emphasize that the main benefits of antihypertensive therapy are due to decreasing blood pressure per se...
  89. ncbi Validating clinical reasoning: a question of perspective, but whose perspective?
    A M Downing
    School of Allied Health Professions, Faculty of Health and Social Care, University of the West of England, Bristol, UK
    Man Ther 8:117-9. 2003
    ..Validity theory applied through different perspectives may, it is argued help to get to grips with the balancing act of validating manual therapy practice...
  90. ncbi Issues in subgroup analyses and meta-analyses of clinical trials
    J Thomas Bigger
    Departments of Medicine and Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Cardiovasc Electrophysiol 14:S6-8. 2003
    ..Meta-analysis is a formal way of summarizing the totality of information coming from well-conducted randomized clinical trials. The use and limitations of these two techniques are discussed...
  91. ncbi [Evidence-based antibiotic prophylaxis in aseptic orthopedic surgery]
    K P Hunfeld
    Institut fur Medizinische Mikrobiologie, Klinikum, Johann Wolfgang Goethe Universitat, Frankfurt M
    Orthopade 32:1070-7. 2003
    ..Antibiotic administration may be repeated in the OR when surgery lasts longer than 3 h. The use of local antibiotics in bone cement has not proven useful as a prophylactic measure...
  92. ncbi An introduction to systematic reviews in respiratory medicine
    P W Jones
    Division of Physiological Medicine, St George s Hospital Medical School, London, UK
    Respir Med 97:97-103. 2003
    ....
  93. ncbi [Evidence based treatment of epilepsy]
    J A Armijo
    Servicio de Farmacología Clínica Hospital Universitario Marqués de Valdecilla Santander, Cantabria, Espana
    Rev Neurol 35:S59-73. 2002
    ..Through systematic reviews, critical evaluation, and statistical strategies such as meta analysis it aids to take decisions in clinical practice...
  94. ncbi Capture-recapture is a potentially useful method for assessing publication bias
    Derrick A Bennett
    The Clinical Trials Research Unit, 3 Ferncroft Street, Grafton, Faculty of Medicine and Health Sciences, Private Bag 92019, University of Auckland, New Zealand
    J Clin Epidemiol 57:349-57. 2004
    ..The aim of this study was to assess the influence of publication bias in a systematic review of the effectiveness of Progressive Resistance Training (PRT) in older people...
  95. ncbi The evidence base for complementary and alternative medicine: methods of Evidence Mapping with application to CAM
    David L Katz
    Yale Prevention Research Center, Department of Epidemiology and Public Health, Yale University School of Medicine, USA
    Altern Ther Health Med 9:22-30. 2003
    ..There is widespread concern regarding the adequacy of evidence for specific practices under the rubric of "complementary and alternative medicine" (CAM)...
  96. ncbi Cochrane neonatal systematic reviews: a survey of the evidence for neonatal therapies
    John C Sinclair
    Department of Pediatrics, McMaster University Medical Centre, Room 3N11F, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Clin Perinatol 30:285-304. 2003
    ..Most CNRG reviews were current. There is a continuing need to prepare systematic review of therapies not yet covered and to keep an increasing number of reviews up-to-date...
  97. ncbi The case against "the evidence": a different perspective on evidence-based medicine
    D D R Williams
    Cefn Coed Hospital, Swansea SA2 0GH, UK
    Br J Psychiatry 180:8-12. 2002
    ..Many doctors are now critical of the emphasis being placed on "the evidence" and concerned that clinical practice will become more constrained...
  98. ncbi [Evidence-based clinical practice]
    Christian Gluud
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:541-7. 2002
    ..By investments in education, applied research, and The Cochrane Collaboration, evidence-based medicine may form a stronger basis for clinical practice...
  99. ncbi Epidural block and outcome after major surgery
    Paul S Myles
    Med J Aust 177:536-7. 2002
    ..Patients at increased risk of postoperative respiratory complications may benefit...
  100. ncbi Publications in anesthesia journals: quality and clinical relevance
    Jakob Lauritsen
    Department of Anesthesia, Herlev University Hospital, Herlev, Denmark
    Anesth Analg 99:1486-91; table of contents. 2004
    ..We compared the Journal Impact Factor (a measure of the number of citations per article in a journal) and the proportion of clinically relevant pages and found that they were inversely proportional to each other...
  101. ncbi Survey of systematic reviews in dentistry
    James Bader
    Department of Operative Dentistry, School of Dentistry, University of North Carolina, Chapel Hill 27599 7450, USA
    J Am Dent Assoc 135:464-73. 2004
    ..The authors describe the steps taken in systematic reviews and perform a literature survey to identify published systematic reviews of topics relevant to clinical dentistry...

Research Grants78

  1. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ....
  2. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..The evaluation of target organ damage, ESRD, and cardiovascular events among those with masked hypertension may unmask its malignant characteristics and improve our ability to treat this condition more effectively. ..
  3. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ....
  4. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..The safety profile of DCS is well-known from its use for over 50 years to treat infections, and the risk of serious side effects would be minimal, especially when taken at low doses over short periods as in this study. ..
  5. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..We propose to screen this region of susceptibility in zebrafish, cell lines, and mice for functional elements that may lead to atrial fibrillation. ..
  6. Does ArsenicMitigation in BangladeshRaiseExposure to Bacterial and ViralPathogens
    ALEXANDER FRANS VAN GEEN; Fiscal Year: 2010
    ....
  7. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    ..n=2850) corresponding to the lead SNPs from our combined discovery cohort analysis (Aim 1) for replication/meta analysis;and 3) Strengthen the NAPS2 pancreatitis cohort by ascertaining additional subjects (N=700)...
  8. Advanced Glycation End-Products and Risk of Pancreatic Cancer
    Li Jiao; Fiscal Year: 2013
    ..This cost-efficient study approved as an ancillary WHI study will provide insight into a novel etiological pathway, CML-AGE/RAGE, in pancreatic cancer development in women. ..
  9. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ....
  10. Genetics and Genomics of Maternal Glycemia During Pregnancy
    William L Lowe; Fiscal Year: 2013
    ....
  11. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..The investigators will develop new methods and predictive tools that will inform clinical decisions and target interventions aimed at the prevention of atrial fibrillation. ..
  12. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..Reduced pain and stiffness in weight bearing joints may help reduce demand for total joint replacement surgery in this population. ..
  13. Novel IL-15 Superagonist Therapy for Bladder Cancer
    Hing C Wong; Fiscal Year: 2011
    ....
  14. Expression-Based Multi-Gene Signatures for CRC Recurrence and Chemoselection
    Christopher Sears; Fiscal Year: 2012
    ..developer of SmartChip[unreadable] Real-Time PCR System which will be used for improved initial biomarker discovery. ..
  15. The role of DEK in breast cancer development and therapy
    LISA MARIE PRIVETTE VINNEDGE; Fiscal Year: 2010
    ..We hypothesize that the targeting of DEK in breast cancer may be of therapeutic value. ..
  16. Bone Microarchitecture: The Framingham Osteoporosis Study
    Douglas P Kiel; Fiscal Year: 2013
    ....
  17. A Haplotype Map for Multiple Sclerosis
    Stephen L Hauser; Fiscal Year: 2013
    ..This information may translate into clinically useful genetic biomarkers and reveal novel targets for therapy. ..
  18. Narrow-spectrum Agents Acting against Helicobacter pylori
    Kenneth Coleman; Fiscal Year: 2013
    ....
  19. Designing HIV Protease Inhibitors with Lower Dosing Requirements and Lower Toxici
    Mitchell W Mutz; Fiscal Year: 2013
    ..By reducing the toxicity of HIV protease inhibitors, we hope to improve compliance with HAART and therapeutic outcomes. ..
  20. Primary care eHealth intervention for improved outcomes in chronic kidney disease
    Veronica Yank; Fiscal Year: 2013
    ..The eHealth intervention has the potential to improve the health of millions of patients with CKD not yet receiving effective medications and to be expanded to related diseases. ..
  21. Who benefits from Colorectal Cancer Screening? A subgroup Analysis of the Minnes
    Aasma Shaukat; Fiscal Year: 2013
    ..We are interested in exploring the relationship between consumption of NSAIDs, high fiber diet and BMI as effect modifiers of effectiveness of screening. ..
  22. An Appearance-Based Intervention to Reduce Teen Skin Cancer Risk
    Joel J Hillhouse; Fiscal Year: 2013
    ..If successful, its dissemination has the potential to substantially reduce future melanoma and non-melanoma skin cancer morbidity and mortality in adolescents. ..
  23. Childhood Illness and Risk Perception: Opportunity to Improve Handwashing
    Pavani Kalluri Ram; Fiscal Year: 2010
    ..Results from this study will be useful for international and civil society organizations worldwide that are trying to reduce the two million deaths from diarrhea occurring each year. ..
  24. Functional characterization of a novel gene for non-alcoholic fatty liver disease
    ALEXIS L GORDEN; Fiscal Year: 2011
    ..This research may lead to novel targets and strategies for prevention and treatment of NAFLD. ..
  25. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..Findings of this study may provide important information that could shape dietary recommendations to prevent coronary events. ..
  26. Predictive Modeling with Clinical and Genomic Data in COPD
    PETER CASTALDI; Fiscal Year: 2013
    ..abstract_text> ..
  27. Effects of tai chi chuan on psychobiological indicators of anxiety and sleep qual
    KAREN LEIGH CALDWELL; Fiscal Year: 2012
    ..Information about who responds to tai chi chuan will be valuable in formulating treatment recommendations for young adults with symptoms of anxiety and attendant poor sleep quality. ..
  28. Meta-Analysis of Biobehavioral Determinants of Health Outcomes in Type 2 Diabetes
    Sharon A Brown; Fiscal Year: 2012
    ..The information obtained will inform clinical guidelines so that clinicians can effectively address the growing global diabetes epidemic. ..
  29. Meta-Analysis of Interventions to Improve Medication Adherence
    Vicki S Conn; Fiscal Year: 2013
    ..The findings will clarify which interventions work best to improve medication adherence. The study will also determine if interventions work best for people with particular characteristics. ..
  30. Genomics and pharmacodynamics of statin-related rhabdomyolysis
    Bruce M Psaty; Fiscal Year: 2013
    ..For validation and translational work, co- investigators will use variants discovered by exome sequencing and replicated by our UK collaborators to conduct basic-science studies and evaluate their function. ..
  31. Genetic Determinants of Visceral Adiposity
    Yongmei Liu; Fiscal Year: 2013
    ..Identification of these genetic factors may help to determine, at a relatively early age, who is at risk of fat related diseases and needs aggressive treatment to prevent the fat related diseases. ..
  32. Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
    Douglas P Kiel; Fiscal Year: 2012
    ..The newly discovered genes will identify previously unsuspected disease pathways that may lead to new treatments for osteoporosis. ..
  33. Genetic and Genomic Dissection of Psoriatic Arthritis
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..The results of this research are also likely to be relevant to other autoimmune diseases. ..
  34. Targeting Metastasis Induced by Mesenchymal Stem Cells in the Tumor Stroma
    Shrikanta Chattopadhyay; Fiscal Year: 2013
    ..The proposed studies are ideally suited for my goal of transitioning into an academic physician-scientist specialized in small-molecule inhibitors of the breast cancer microenvironment. ..
  35. Properties of HIV-1 DNA/RNA Assays for Detecting HIV Infection in Infants
    Raji Balasubramanian; Fiscal Year: 2012
    ....
  36. The comparative effectiveness of kidney transplantation in advanced CKD
    MORGAN ERIKA GRAMS; Fiscal Year: 2013
    ..Furthermore, identification of characteristics associated with high cardiovascular and mortality risk may be used to guide therapy and future trials in the advanced chronic kidney disease population. ..
  37. Development of a Field Applicable Screening Tool (FAST) kit for detecting resista
    MARTIN JAMES DONNELLY; Fiscal Year: 2013
    ..We propose to develop assays that will allow disease programme managers to detect resistance when it is still at a low frequency and before control failure has occurred. ..
  38. AD Gene Discovery: Exome Chip, New Endophenotypes &Functional Studies in CHARGE
    Sudha Seshadri; Fiscal Year: 2013
    ..We seek modest analytic resources to leverage existing phenotypic and genotypic data worth millions, to discover new AD genes and potentially novel prevention and treatment approaches for AD. ..
  39. TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus
    Patrick M Gaffney; Fiscal Year: 2012
    ..This work has the potential to lead to new treatments for SLE and to new tests for diagnosing and monitoring the disease. ..
  40. Genetic Architecture of Adiposity in Multiple Large Cohorts
    Kari E North; Fiscal Year: 2013
    ..This work will stimulate the discovery of variants and pathways, and potentially extend our understanding of the genetic basis of obesity risk and suggest potential therapeutic targets. ..
  41. TGF-beta polymorphisms and breast cancer in families
    Boris Pasche; Fiscal Year: 2013
    ..This project will study 65 genes of the TGF-2 pathway in 5357 women with breast cancer and their unaffected sisters and determine which genes are associated with breast cancer risk. ..
  42. Genetics of Foot Disorders
    Joanne M Jordan; Fiscal Year: 2012
    ....
  43. White Matter Integrity and Alcohol Use Disorders
    Mollie Monnig; Fiscal Year: 2012
    ..Its ultimate aim is to elucidate how alcohol-related damage occurs in white matter networks underlying reward and self-regulation and how this damage may affect functional outcomes. ..
  44. The EVE Asthma Genetics Consortium: Building Upon GWAS
    CAROLE contact OBER; Fiscal Year: 2010
    ..Discovery of risk alleles for asthma and its associated phenotypes could significantly impact public health and health care delivery. ..
  45. Integrating Genomic and Environmental Perspectives on Internalizing Disorders
    DANIEL E ADKINS; Fiscal Year: 2013
    ..In sum, the CBRPM provides a stimulating and supportive institutional environment with the all of the statistical, computational and laboratory resources necessary to make this proposal a successful one. ..
  46. PEDIATRIC AND MATERNAL HIV STUDIES COORDINATING CENTER
    CAROL NESEL; Fiscal Year: 2010
    ..k. ..
  47. PEDIATRIC AND MATERNAL HIV STUDIES COORDINATING CENTER
    CAROL NESEL; Fiscal Year: 2012
    ..k. ..
  48. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy J Thompson; Fiscal Year: 2010
    ..If one-third of the more than 3 million people in the United states with epilepsy are depressed and we can reduce that number by 12%, 120,000 people will be protected. ..
  49. PEDIATRIC AND MATERNAL HIV STUDIES COORDINATING CENTER
    CAROL NESEL; Fiscal Year: 2011
    ..k. ..
  50. PEDIATRIC AND MATERNAL HIV STUDIES COORDINATING CENTER
    CAROL NESEL; Fiscal Year: 2009
    ..k...
  51. Atlases to Report and Correlate Radiotherapy Dose Distributions with Outcomes
    Andrew Jackson; Fiscal Year: 2013
    ..This should permit the safe delivery of higher biologically effective doses to tumors, resulting in improved local control. ..
  52. Vitamin D and the prevalence, incidence, and persistence of bacterial vaginosis
    Abigail Norris Turner; Fiscal Year: 2012
    ..Vitamin D is safe, inexpensive and has many health benefits. If vitamin D is also associated with BV, supplementation with this essential vitamin may have substantial impact on women's reproductive health worldwide. ..
  53. Functional Genomics of Psoriasis
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..We will also (b) extend these studies to predicted damaging variants at other loci identified from Aims 1 and 2 as likely to be important in immunocytes. ..
  54. Role of the Solute Carrier Gene Family in Hypertension
    Alanna C Morrison; Fiscal Year: 2012
    ....
  55. Functional characterization of pathways regulated by schizophrenia gene TCF4
    JOSEPH LOUIE MCCLAY; Fiscal Year: 2013
    ..All generated data will be deposited in the appropriate public repository. ..
  56. A Rapid, Blood RNA Assay for the Diagnosis of Acute Respiratory Infections
    Neil A Fanger; Fiscal Year: 2013
    ....
  57. A Human-Specific Gene (G72/G30) in Transgenic Mice
    Chunyu Liu; Fiscal Year: 2010
    ..We expect these results will ultimately lead to a better understanding of G72 and its role in both normal human brain function and psychiatric disease states. ..
  58. Incorporating microRNA data and analyses into the leading cancer genomics portal
    Daniel R Rhodes; Fiscal Year: 2012
    ..If successful, this effort will improve public health by providing researchers with additional data and tools to understand and treat this biologically complex disease. ..
  59. Determining the Role of the Potassium Channel, KCNN3, in Atrial Fibrillation
    PATRICK THOMAS ELLINOR; Fiscal Year: 2013
    ..Understanding the molecular determinants of AF will provide insights into the pathogenesis of AF, and eventually provide targets for new therapies to prevent and treat this morbid arrhythmia. ..
  60. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2009
    ..abstract_text> ..
  61. Replication of Association Signals Identified in Ulcerative Colitis GWAS
    Richard H Duerr; Fiscal Year: 2010
    ..The tentative plan is to use a 768-plex Illumina GoldenGate assay to genotype more than 500 of the top ulcerative colitis metaanalysis hits plus a set of SNPs that discern ancestry strata within European ancestry samples. ..
  62. Molecular Characterization of Stage I Lung Cancer
    Ming You; Fiscal Year: 2010
    ..We believe that the 64-gene molecular marker set are validated, adjuvant therapy could be selectively administered to those patients at high risk for relapse. ..
  63. Better Decisions, Better Care: Advancing decision support to improve health care
    Nananda Col; Fiscal Year: 2006
    ..This is a venue in which strong intellectual challenges to the status quo can engage the best researchers in the field. ..
  64. DIETARY TREATMENT OF DIABETES MELITUS--META ANALYSIS
    Zung Tran; Fiscal Year: 1991
    ..The results of this project should provide a clarification of the contributions of diet therapy to changes in metabolic control and the CAD lipid risk factor in humans subjects with NIDDM...
  65. Biomarkers of Formaldehyde Exposure and Toxicity
    Luoping Zhang; Fiscal Year: 2010
    ..The data produced from these studies will be useful to public health agencies in their evaluation of the leukemia risk presented by formaldehyde. ..
  66. META ANALYSIS OF CLINICAL INFORMATION SERVICE TRIALS
    E Balas; Fiscal Year: 2001
    ..Sensitivity analysis will assess the potential modifying effect of unpublished studies on the validity of our conclusions. ..
  67. Clinical and Cost-effectiveness of biologics in Rheumatoid Arthritis
    Hyon K Choi; Fiscal Year: 2010
    ..This project will provide comprehensive information that has important implications for clinical care, public health, and future research funding allocations on this crucial topic, in a highly cost-efficient design. ..
  68. Blood vs. bone marrow stem transplant
    Benjamin Djulbegovic; Fiscal Year: 2003
    ..We will test all these hypotheses by collecting individual-patient data on each outcomes of interest from the existing data sets (i.e. from published and unpublished randomized studies) using the techniques of SR/MA. ..
  69. DIABETES SELF-MANAGEMENT OUTCOMES: A META-ANALYSIS
    Sandra Upchurch; Fiscal Year: 2001
    ..Results of the meta-analysis will be used by the Principal Investigator to design a diabetes self-management education intervention. ..
  70. Maintenance and correlates of cooperative behavior in therapeutic communities
    KEITH LEVERETT WARREN; Fiscal Year: 2010
    ..This knowledge will allow therapeutic community clinicians to foster more clinically effective interactions between residents. ..
  71. Improving Meta-Analysis of Diagnostic Test Studies
    Christopher Schmid; Fiscal Year: 2004
    ..These tasks will contribute to the development of recommendations for improving diagnostic test meta-analyses. ..
  72. Chronic Renal Disease-Individual Patient Meta Analysis
    Andrew Levey; Fiscal Year: 2007
    ..The results will have a major impact on the care of patients with chronic kidney disease. ..
  73. Chronic Renal Disease-Individual Patient Meta Analysis
    Andrew Levey; Fiscal Year: 2004
    ..The results will have a major impact on the care of patients with chronic kidney disease. ..
  74. Test of a Web-Based Program to Improve Adherence to HIV/AIDS Medications
    Royer F Cook; Fiscal Year: 2010
    ..This will greatly expand access to an effective medication adherence program, thereby improving the physical and mental health of those infected with HIV. ..
  75. ENERGY RESTRICTION AND EXERCISE--A META-ANALYSIS
    Joseph Donnelly; Fiscal Year: 2001
    ..The investigators state that this investigation should provide clarification of the utility of exercise and/or energy restriction and provide direction for future research. ..
  76. UTILIZATION OF RESEARCH ON CARDIOVASCULAR TECHNOLOGIES
    PAUL WORTMAN; Fiscal Year: 1990
    ..Our preliminary research (reported in Section C) clearly demonstrates that the above approaches can be easily accommodated using our current databases and should be fully investigated before resorting to other procedures...
  77. Attentional Dysfunction and Recovery in Traumatic Brain Injury (TBI)
    ANDREW ROBERT MAYER; Fiscal Year: 2010
    ..Moreover, these bio- markers may be useful for distinguishing the small percentage of mild TBI patients who continue to have cognitive problems due to the injury. ..
  78. Adherence with Sleep Apnea Treatments: A Meta-Analysis
    Carl Stepnowsky; Fiscal Year: 2009
    ..The goal of the project is to identify necessary future research strategies and factors with the greatest potential for behavioral intervention to increase adherence and improve health outcomes for SRBD patients. ..