prospective studies

Summary

Summary: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Top Publications

  1. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
  2. ncbi A modified poisson regression approach to prospective studies with binary data
    Guangyong Zou
    Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada
    Am J Epidemiol 159:702-6. 2004
  3. doi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
  4. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
  5. ncbi Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 351:781-91. 2004
  6. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
  7. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
  8. ncbi Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
    Matthias Egger
    Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
    Lancet 360:119-29. 2002
  9. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
  10. pmc Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
    Paul E Ronksley
    Department of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada
    BMJ 342:d671. 2011

Detail Information

Publications306 found, 100 shown here

  1. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
    ..The influence of excess body weight on the risk of death from cancer has not been fully characterized...
  2. ncbi A modified poisson regression approach to prospective studies with binary data
    Guangyong Zou
    Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada
    Am J Epidemiol 159:702-6. 2004
    ..Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100. The method is illustrated with two data sets...
  3. doi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
    ..Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories...
  4. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
  5. ncbi Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 351:781-91. 2004
    ..We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer...
  6. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    ..To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages...
  7. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  8. ncbi Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
    Matthias Egger
    Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
    Lancet 360:119-29. 2002
    ..The ART Cohort Collaboration, which includes 13 cohort studies from Europe and North America, was established to fill this knowledge gap...
  9. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
    ..Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors...
  10. pmc Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
    Paul E Ronksley
    Department of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada
    BMJ 342:d671. 2011
    ..To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes...
  11. ncbi Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Cape Town, South Africa
    AIDS 19:2141-8. 2005
    ..To determine rates, risk factors and causes of death among patients accessing a community-based antiretroviral treatment (ART) programme both prior to and following initiation of treatment...
  12. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  13. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  14. doi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
    ....
  15. pmc Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study
    W S Lim
    Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 58:377-82. 2003
    ..A multicentre study was conducted to derive and validate a practical severity assessment model for stratifying adults hospitalised with CAP into different management groups...
  16. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  17. pmc Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults
    Alpa V Patel
    Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA
    Am J Epidemiol 172:419-29. 2010
    ..The time spent sitting was independently associated with total mortality, regardless of physical activity level. Public health messages should include both being physically active and reducing time spent sitting...
  18. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabak
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  19. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    ..To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD)...
  20. ncbi Non-response and related factors in a nation-wide health survey
    K Korkeila
    Department of General Practice, University of Turku, Finland
    Eur J Epidemiol 17:991-9. 2001
    ..To analyse selective factors associated with an unexpectedly low response rate...
  21. ncbi Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    D H O'Leary
    Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
    N Engl J Med 340:14-22. 1999
    ..We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease...
  22. ncbi Decline in the AIDS and death rates in the EuroSIDA study: an observational study
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 362:22-9. 2003
    ..Since the introduction of highly active antiretroviral therapy (HAART), little is known about whether changes in HIV-1 mortality and morbidity rates have been sustained. We aimed to assess possible changes in these rates across Europe...
  23. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  24. doi Sedentary behaviors and health outcomes among adults: a systematic review of prospective studies
    Karin I Proper
    Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands
    Am J Prev Med 40:174-82. 2011
    ..To date, there is no review of prospective studies that systematically examined the relationship between diverse sedentary behaviors and various health ..
  25. ncbi Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    George Ostapowicz
    Department of Medicine, Gold Coast Hospital, 108 Nerang Street, Southport, QLD 4215, Australia
    Ann Intern Med 137:947-54. 2002
    ..Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition...
  26. ncbi Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission
    Ellen R Cooper
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, 774 Albany Street, Suite 506, Boston, MA 02118, U S A
    J Acquir Immune Defic Syndr 29:484-94. 2002
    ..The Women and Infants Transmission Study is a prospective natural history study that has been enrolling HIV-1-infected pregnant women and their infants since 1989...
  27. ncbi The incidence and severity of adverse events affecting patients after discharge from the hospital
    Alan J Forster
    University of Ottawa, F654 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Ann Intern Med 138:161-7. 2003
    ..Studies of hospitalized patients identify safety as a significant problem, but few data are available regarding injuries occurring after discharge. Patients may be vulnerable during this transition period...
  28. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  29. pmc Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 339:b4229. 2009
    ..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
  30. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
    ..We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease...
  31. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  32. ncbi What do we mean by validating a prognostic model?
    D G Altman
    ICRF Medical Statistics Group, Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, UK
    Stat Med 19:453-73. 2000
    ..We illustrate the issues using several case studies...
  33. ncbi Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
    ..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
  34. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  35. pmc Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis
    Patrice Carter
    Diabetes Research, Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW
    BMJ 341:c4229. 2010
    ..To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes...
  36. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  37. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
    ..Adherence to a Mediterranean diet may improve longevity, but relevant data are limited...
  38. doi An algorithm for tuberculosis screening and diagnosis in people with HIV
    Kevin P Cain
    U S Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA 30333, USA
    N Engl J Med 362:707-16. 2010
    ..No internationally accepted, evidence-based guideline addresses the optimal means of conducting such screening, although screening for chronic cough is common...
  39. pmc The Rotterdam Study: 2010 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam The Netherlands
    Eur J Epidemiol 24:553-72. 2009
    ..epib.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  40. doi Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies
    K J Anstey
    Ageing Research Unit, Centre for Mental Health Research Medical School, Australian National University, Canberra, ACT, Australia
    Obes Rev 12:e426-37. 2011
    ..in midlife and late-life) and dementia was investigated in meta-analyses of 16 articles reporting on 15 prospective studies. Follow-ups ranged from 3.2 to 36.0 years...
  41. doi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  42. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  43. doi Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
    Am J Clin Nutr 92:1189-96. 2010
    ..The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes...
  44. pmc Rapid DNA methylation changes after exposure to traffic particles
    Andrea Baccarelli
    Laboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Am J Respir Crit Care Med 179:572-8. 2009
    ..Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis...
  45. pmc Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk
    Jane Green
    Cancer Epidemiology Unit, University of Oxford, UK
    Lancet Oncol 12:785-94. 2011
    ....
  46. ncbi Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium manu malbrain skynet be
    Intensive Care Med 30:822-9. 2004
    ..This study assessed the prevalence of IAH and its risk factors in a mixed population of intensive care patients...
  47. ncbi Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  48. ncbi Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)
    Amanda I Adler
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, and South Cleveland Hospital, Cleveland, United Kingdom
    Kidney Int 63:225-32. 2003
    ..This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death...
  49. ncbi Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies
    Kaarin J Anstey
    Centre for Mental Health Research, School of Psychology, The Australian National University, Canberra, Australia
    Am J Epidemiol 166:367-78. 2007
    The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up...
  50. ncbi C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    ..Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events...
  51. doi Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
    Stavros N Karamanakos
    Nutrition Support and Morbid Obesity Unit, Department of Surgery, University of Patras School of Medicine, Patras, Greece
    Ann Surg 247:401-7. 2008
    ..Bariatric surgery is currently the most effective treatment in morbidly obese patients, leading to durable weight loss...
  52. doi Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascula
    James H Stein
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
  53. ncbi Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults
    C R Brewin
    Subdepartment of Clinical Health Psychology, University College London, England
    J Consult Clin Psychol 68:748-66. 2000
    ....
  54. ncbi The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)
    Elaine Thomas
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    Pain 110:361-8. 2004
    ..More importantly the extent to which pain interferes with everyday life increases incrementally with age up to the oldest age-group in the community-dwelling general population...
  55. pmc Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 329:1212. 2004
    ..To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission...
  56. pmc Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
    Pasquale Strazzullo
    Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy
    BMJ 339:b4567. 2009
    ..To assess the relation between the level of habitual salt intake and stroke or total cardiovascular disease outcome...
  57. doi Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:506-11. 2010
    ..The objective of the present study was to evaluate the safety of withholding antimalarials in febrile children who have a negative test result...
  58. pmc Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
    Alexander Thompson
    Lp PLA2 Studies Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:1536-44. 2010
    ..We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances...
  59. pmc Risk factors of influenza transmission in households
    Cecile Viboud
    Epidemiology and Information Sciences, Universite Pierre et Marie Curie, Paris
    Br J Gen Pract 54:684-9. 2004
    ..Influenza transmission in households is a subject of renewed interest, as the vaccination of children is currently under debate and antiviral treatments have been approved for prophylactic use...
  60. ncbi Gait variability and fall risk in community-living older adults: a 1-year prospective study
    J M Hausdorff
    Gerontology Division, Beth Israel Deaconess Medical Center and Division on Aging, Harvard Medical School, Boston, MA 02215, USA
    Arch Phys Med Rehabil 82:1050-6. 2001
    ..To test the hypothesis that increased gait variability predicts falls among community-living older adults attending an outpatient clinic...
  61. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  62. ncbi A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    Fred A Zar
    University of Illinois at Chicago, Chicago, IL 60612 7323, USA
    Clin Infect Dis 45:302-7. 2007
    ..We conducted such a trial, stratifying patients according to disease severity, to investigate whether one agent was superior for treating either mild or severe disease...
  63. ncbi Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study
    J R Ickovics
    Yale University, Department of Epidemiology and Public Health, PO Box 208034, 60 College St, Suite 415, New Haven, CT 06520 8034, USA
    JAMA 285:1466-74. 2001
    ..The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts...
  64. pmc Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review
    Jeroen S L de Munter
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e261. 2007
    ..We evaluated intakes of whole grain, bran, and germ in relation to risk of type 2 diabetes in prospective cohort studies...
  65. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  66. ncbi Sexual behavior of HIV discordant couples after HIV counseling and testing
    Susan Allen
    Department of Epidemiology and International Health, School of Public Health, University of Alabama in Birmingham, 35294, USA
    AIDS 17:733-40. 2003
    ..Biological markers were used to assess the validity of self-report...
  67. doi Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 27:3757-63. 2009
    ..Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity...
  68. ncbi Changes in sexual behavior and risk of HIV transmission after antiretroviral therapy and prevention interventions in rural Uganda
    Rebecca Bunnell
    CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    AIDS 20:85-92. 2006
    ..The impact of antiretroviral therapy (ART) on sexual risk behavior and HIV transmission among HIV-infected persons in Africa is unknown...
  69. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  70. ncbi Validity of self-reported height and weight in 4808 EPIC-Oxford participants
    Elizabeth A Spencer
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
    Public Health Nutr 5:561-5. 2002
    ....
  71. ncbi Prospective assessment of falls in Parkinson's disease
    B R Bloem
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    J Neurol 248:950-8. 2001
    ..Recurrent fallers were best predicted by disease severity and presence of prior falls. Strategies to prevent falls in PD should particularly focus at intrinsic (patient-related) factors, such as minimising the use of benzodiazepines...
  72. ncbi Surgery versus prolonged conservative treatment for sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 356:2245-56. 2007
    ..Lumbar-disk surgery often is performed in patients who have sciatica that does not resolve within 6 weeks, but the optimal timing of surgery is not known...
  73. pmc Tuberculosis during the first year of antiretroviral therapy in a South African cohort using an intensive pretreatment screening strategy
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    AIDS 24:1323-8. 2010
    ....
  74. pmc Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 51:823-9. 2010
    ..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa...
  75. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
    ..P. falciparum infection has harmful effects in pregnancy, but the effects of P. vivax have not been characterised. We investigated the effects of P. vivax infection during pregnancy...
  76. ncbi Silent brain infarcts and the risk of dementia and cognitive decline
    Sarah E Vermeer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 348:1215-22. 2003
    ..Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia and cognitive decline...
  77. ncbi A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    Vivian G Loo
    Department of Microbiology, McGill University Health Center, Montreal, Que, Canada
    N Engl J Med 353:2442-9. 2005
    ..In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea...
  78. ncbi Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: a population-based prospective cohort study of 57,053 men and women in Denmark
    Anne Tjønneland
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    Scand J Public Health 35:432-41. 2007
    ..The aims of this paper are to give a description of the study design, measurement procedures, and differences between participants and non-participants with special reference to socioeconomic characteristics...
  79. ncbi Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    J B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne 3181, Victoria, Australia
    Gastroenterology 121:91-100. 2001
    ..Predicting advanced or progressive disease may help in selecting patients for liver biopsy and assist the development of therapeutic options...
  80. ncbi Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 113:969-76. 2006
    ..In the present study, the relationship between transmural posterolateral scar tissue and response to CRT was evaluated...
  81. pmc Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa
    S A Allen
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    AIDS Res Hum Retroviruses 17:901-10. 2001
    ..FTM and MTF transmission rates were similar. These data suggest gender-specific differences in the biology of heterosexual transmission...
  82. pmc Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study
    Julia Hippisley-Cox
    Tower Building, University Park, Nottingham NG2 7RD
    BMJ 335:136. 2007
    ..To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN)...
  83. ncbi Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease
    Jack Zigler
    Texas Back Institute Texas Health Research Institute, Plano, TX 75093, USA
    Spine (Phila Pa 1976) 32:1155-62; discussion 1163. 2007
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  84. pmc Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients
    Fanny Turrel-Davin
    Joint Unit Hospices Civils de Lyon bioMérieux, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Crit Care 14:R133. 2010
    ..However, no routine biomarkers of apoptosis are so far available in patients. Thus, the aim of our study was to assess the different biomarkers of apoptosis putatively usable on a routine basis in septic shock...
  85. doi Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients W
    Young Hoon Jeong
    Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea
    J Am Coll Cardiol 53:1101-9. 2009
    ..The purpose of this study was to determine the impact of adjunctive cilostazol in patients with high post-treatment platelet reactivity (HPPR) undergoing coronary stenting...
  86. ncbi Positioning of total knee arthroplasty with and without navigation support. A prospective, randomised study
    M Sparmann
    Orthopaedic Department, Immanuel Hospital, Free University of Berlin, Berlin, Germany
    J Bone Joint Surg Br 85:830-5. 2003
    ..0001). The use of a navigation system was therefore shown to improve the alignment of the implant...
  87. ncbi The utility of radiological imaging in nonalcoholic fatty liver disease
    Sherif Saadeh
    Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastroenterology 123:745-50. 2002
    ..This prospective study evaluates the role of radiological modalities in establishing the diagnosis of nonalcoholic steatohepatitis (NASH)...
  88. doi Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study
    Anja Haase-Fielitz
    Department of Intensive Care, Austin Health, Melbourne, Australia
    Crit Care Med 37:553-60. 2009
    ..To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function...
  89. pmc Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
    ..A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia...
  90. pmc Endoscopic mucosal resection for treatment of early gastric cancer
    H Ono
    Department of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Gut 48:225-9. 2001
    ..Bleeding and perforation (5%) were two major complications of EMR but there were no treatment related deaths. CONCLUSION: In our experience, EMR allows us to perform less invasive treatment without sacrificing the possibility of cure...
  91. ncbi Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform
    A L Pauca
    Anesthesiology Departmen, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Hypertension 38:932-7. 2001
    ..5+/-7.3 and 15.1+/-7.3 mm Hg for nitroglycerin). Use of a generalized transfer function to synthesize radial artery pressure waveforms can provide substantially equivalent values of aortic systolic, pulse, mean, and diastolic pressures...
  92. ncbi Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants?
    Lily C Chow
    Division of Neonatology, Department of Pediatrics, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA
    Pediatrics 111:339-45. 2003
    ....
  93. ncbi Validation of a modified Early Warning Score in medical admissions
    C P Subbe
    Department of Medicine, Wrexham Maelor Hospital, Wrexham, UK
    QJM 94:521-6. 2001
    ..A clinical pathway could be created, using nurse practitioners and/or critical care physicians, to respond to high scores and intervene with appropriate changes in clinical management...
  94. ncbi Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition DIfE, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Natl Cancer Inst 98:920-31. 2006
    ..This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women...
  95. ncbi Human immunodeficiency virus and the outcome of treatment for new and recurrent pulmonary tuberculosis in African patients
    J Murray
    National Centre for Occupational Health, Department of Health, Johannesburg, South Africa
    Am J Respir Crit Care Med 159:733-40. 1999
    ..Particular vigilance is needed for concurrent infections, which may contribute significantly to mortality during treatment of TB in HIV-positive patients...
  96. ncbi Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies
    Augusto Di Castelnuovo
    Laboratory of Genetic and Environmental Epidemiology, John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Arch Intern Med 166:2437-45. 2006
    Moderate consumption of alcohol is inversely related with coronary disease, but its association with mortality is controversial. We performed a meta-analysis of prospective studies on alcohol dosing and total mortality.
  97. pmc Structural and environmental barriers to condom use negotiation with clients among female sex workers: implications for HIV-prevention strategies and policy
    Kate Shannon
    British Columbia Centre for Excellence in HIV AIDS, Vancouver, BC, Canada
    Am J Public Health 99:659-65. 2009
    ..We investigated the relationship between environmental-structural factors and condom-use negotiation with clients among female sex workers...
  98. ncbi Epidemiology of congenital malaria in Nigeria: a multi-centre study
    Catherine Falade
    Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
    Trop Med Int Health 12:1279-87. 2007
    ..To determine the burden of congenital malaria in newborns in Nigeria...
  99. pmc Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa
    S Allen
    Department of Pathology, University of California, San Francisco
    BMJ 304:1605-9. 1992
    ..Confidential HIV serotesting with counselling caused a large increase in condom use and was associated with a lower rate of new HIV infections. HIV testing is a promising intervention for preventing the spread of HIV in African cities...
  100. doi Psychological distress after severe trauma: a prospective 1-year follow-up study of a trauma intensive care unit population
    Kirsti Tøien
    Intensive Care Unit, Oslo University Hospital, Ulleval, Oslo, Norway
    J Trauma 69:1552-9. 2010
    ..The aim of the study was to investigate the level of psychologic distress after trauma and intensive care unit (ICU) stay, memory from the ICU, and predictors for psychologic distress at 12 months...
  101. ncbi Avoidable stillbirths and neonatal deaths in rural Tanzania
    Sven G Hinderaker
    Centre for International Health, University of Bergen, Norway
    BJOG 110:616-23. 2003
    ..To determine the causes of stillbirths and neonatal deaths in the community in rural Tanzania and to evaluate whether the deaths were avoidable under the prevailing circumstances...

Research Grants87

  1. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2010
    ..evaluate pre-diagnostic genomic methylation of leukocyte DNA in relation to colorectal cancer risk in large prospective studies and expect that individuals with reduced levels of genomic DNA methylation are at increased risk of ..
  2. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2009
    ..evaluate pre-diagnostic genomic methylation of leukocyte DNA in relation to colorectal cancer risk in large prospective studies and expect that individuals with reduced levels of genomic DNA methylation are at increased risk of ..
  3. IMMUNOLOGIC BASIS OF COW MILK INDUCED HYPERSENSITIVITIES
    Hugh Sampson; Fiscal Year: 1999
    Cow mil is one of the major causes of food hypersensitivity in children. Based on 4 prospective studies, 2.5% of infants develop cow milk allergy in the first year of life [100,000 babies/year in the U.S...
  4. IMMUNOLOGIC BASIS OF COW MILK INDUCED HYPERSENSITIVITIES
    Hugh Sampson; Fiscal Year: 2000
    Cow mil is one of the major causes of food hypersensitivity in children. Based on 4 prospective studies, 2.5% of infants develop cow milk allergy in the first year of life [100,000 babies/year in the U.S...
  5. IMMUNOLOGIC BASIS OF COW MILK INDUCED HYPERSENSITIVITIES
    Hugh Sampson; Fiscal Year: 2002
    Cow mil is one of the major causes of food hypersensitivity in children. Based on 4 prospective studies, 2.5% of infants develop cow milk allergy in the first year of life [100,000 babies/year in the U.S...
  6. IMMUNOLOGIC BASIS OF COW MILK INDUCED HYPERSENSITIVITIES
    Hugh Sampson; Fiscal Year: 2001
    Cow mil is one of the major causes of food hypersensitivity in children. Based on 4 prospective studies, 2.5% of infants develop cow milk allergy in the first year of life [100,000 babies/year in the U.S...
  7. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2010
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  8. Natural History of Urban Leptospirosis
    Albert Icksang Ko; Fiscal Year: 2010
    ..A major barrier to identifying interventions has been the lack of prospective studies on leptospirosis...
  9. Natural History of Urban Leptospirosis
    Albert Ko; Fiscal Year: 2009
    ..A major barrier to identifying interventions has been the lack of prospective studies on leptospirosis...
  10. Empirical eating disorder classification and validation using prospective studies
    ALISON E contact FIELD; Fiscal Year: 2011
    ..We propose to use the two largest prospective studies with frequent assessments of disordered eating during adolescence and young adulthood to empirically derive ..
  11. Empirical eating disorder classification and validation using prospective studies
    Nadia Micali; Fiscal Year: 2010
    ..We propose to use the two largest prospective studies with frequent assessments of disordered eating during adolescence and young adulthood to empirically derive ..
  12. Assessment of Dehydration in Children with Diarrhea in Resource-Limited Settings
    ADAM CARL LEVINE; Fiscal Year: 2012
    ..I will also benefit from the additional experience of managing large, prospective studies under the mentorship of three scientists with extensive experience in conducting public health and global ..
  13. Randomized Trial/Reduce Recurrence/Bacterial Vaginosis
    King Holmes; Fiscal Year: 2003
    ..of reproductive ages, has been linked to female HIV-1 acquisition and infection in both cross sectional and prospective studies. Women in sub-Saharan Africa have the highest prevalence of BV, approximately 40-50 percent in Uganda and ..
  14. Randomized Trial/Reduce Recurrence/Bacterial Vaginosis
    King Holmes; Fiscal Year: 2004
    ..of reproductive ages, has been linked to female HIV-1 acquisition and infection in both cross sectional and prospective studies. Women in sub-Saharan Africa have the highest prevalence of BV, approximately 40-50 percent in Uganda and ..
  15. Randomized Trial/Reduce Recurrence/Bacterial Vaginosis
    King Holmes; Fiscal Year: 2002
    ..of reproductive ages, has been linked to female HIV-1 acquisition and infection in both cross sectional and prospective studies. Women in sub-Saharan Africa have the highest prevalence of BV, approximately 40-50 percent in Uganda and ..
  16. HPV & Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2010
    ..Specifically, using immunohistochemistry we will conduct one of the few prospective studies of the immune infiltrates that distinguish (a) CIN-1 that regress vs progress to CIN-2+, and (b) CIN ..
  17. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..Novel therapies to complement these interventions are urgently needed. Mounting evidence from prospective studies indicates that moderately elevated serum uric acid is a strong, independent predictor of an increased risk ..
  18. Comparative Effectiveness Research in Pediatric Rheumatic Diseases: Leveraging CA
    CAROL A contact WALLACE; Fiscal Year: 2010
    ..and Rheumatology Research Alliance (CARRA) has created the opportunities multi-center retrospective and prospective studies of high impact...
  19. Comparative Effectiveness Research in Pediatric Rheumatic Diseases: Leveraging CA
    Carol Wallace; Fiscal Year: 2009
    ..and Rheumatology Research Alliance (CARRA) has created the opportunities multi-center retrospective and prospective studies of high impact...
  20. Marijuana use, problems, and cannabis use disorders in OIF/OEF/OND veterans
    Jane Metrik; Fiscal Year: 2012
    ..is a paucity of studies on the natural course of marijuana use and associated problems and there are no prospective studies on the comorbidity of cannabis use and affective disorders among veterans following deployment...
  21. Epigenetic predicators of asthma in neonates
    Donata Vercelli; Fiscal Year: 2009
    ..will be considered as bona fide neonatal epigenetic predictors of asthma, and will be proposed for future prospective studies. PUBLIC HEALTH RELEVANCE: This application addresses broad Challenge Area (03) Biomarker discovery and ..
  22. Retrospective Assessment of Military Occupations & Neurodegenerative Diseases
    Lorene M Nelson; Fiscal Year: 2010
    ..Since prospective studies of neurodegenerative diseases such as ALS and PD which have a late age of onset are not usually feasible, ..
  23. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2006
    ..b>Prospective studies have found that women with elevated plasma homocysteine have a substantially increased risk of osteoporotic ..
  24. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2007
    ..b>Prospective studies have found that women with elevated plasma homocysteine have a substantially increased risk of osteoporotic ..
  25. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..b>Prospective studies have found that women with elevated plasma homocysteine have a substantially increased risk of osteoporotic ..
  26. Nicotine Metabolism and the Development of Addiction in Adolescent Light Smokers
    Mark Rubinstein; Fiscal Year: 2009
    ..Since addiction most frequently occurs during adolescence, prospective studies that focus on smoking during this time period are essential to give us information on the effects of ..
  27. Pooling of Prospective Studies of Diet, Lifestyle and ALS
    EILIS O'REILLY; Fiscal Year: 2011
    ..of amyotrophic lateral sclerosis (ALS), we propose to pool the primary data of the Pooling Project of Prospective Studies of Diet and Cancer (Cancer Pooling Project), an international consortium of 28 cohort studies...
  28. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2002
    ..However, no prospective studies have been done to verify these findings...
  29. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2002
    ..However, no prospective studies have been done to verify these findings...
  30. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..However, no prospective studies have been done to verify these findings...
  31. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2003
    ..However, no prospective studies have been done to verify these findings...
  32. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..Novel therapies to complement these interventions are urgently needed. Mounting evidence from prospective studies indicates that moderately elevated serum uric acid is a strong, independent predictor of an increased risk ..
  33. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2001
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  34. A Pooled Longitudinal Analysis of Workplace Carpal Tunnel Syndrome
    David M Rempel; Fiscal Year: 2010
    ..Between 2001 and 2008, seven research groups conducted coordinated, multi-year, prospective studies of US production workers and collected detailed subject-level upper-extremity biomechanical exposure ..
  35. Prospective Studies of Avian Influenza Transmission in Asia
    Gregory Gray; Fiscal Year: 2009
    b>Prospective Studies of Avian Influenza Transmission in Asia The H5N1 avian influenza epidemic that has ravaged multiple species in Asia, now threatens the United States...
  36. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    ..duration has been shown to be associated with an increased risk for hypertension incidence, but previous prospective studies on this association did not examine the potential effect modifiers of menopausal status, hormone ..
  37. Prospective Studies of Avian Influenza Transmission in Asia
    Gregory Gray; Fiscal Year: 2007
    ..This study is innovative in that no such prospective studies of avian influenza infection have been performed among those person's occupationally exposed to ..
  38. Prospective Studies of Avian Influenza Transmission in Asia
    GREGORY CHARLES GRAY; Fiscal Year: 2009
    ..This study is innovative in that no such prospective studies of avian influenza infection have been performed among those person's occupationally exposed to ..
  39. Prospective Studies of Avian Influenza Transmission in Asia
    GREGORY CHARLES GRAY; Fiscal Year: 2010
    ..This study is innovative in that no such prospective studies of avian influenza infection have been performed among those person's occupationally exposed to ..
  40. Prospective Studies of Avian Influenza Transmission in Asia
    Gregory Gray; Fiscal Year: 2009
    ..This study is innovative in that no such prospective studies of avian influenza infection have been performed among those person's occupationally exposed to ..
  41. EPIDEMIOLOGY OF HEPATOCELLULAR CARCINOMA & HEPATITIS B VIRUS IN 3 POPULATIONS
    W London; Fiscal Year: 2002
    Description: (Applicant's Description) Prospective studies of 60,984 men in Haimen City, China and 19,469 men in Senegal, west Africa revealed a 14-fold greater death rate from hepatocellular carcinoma (HCC) among the Haimen (168 per 100,..
  42. Prospective Studies of Avian Influenza Transmission in Asia
    Gregory Gray; Fiscal Year: 2006
    ..This study is innovative in that no such prospective studies of avian influenza infection have been performed among those person's occupationally exposed to ..
  43. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ..This registry will provide a foundation for rigorous prospective studies including large, practical, randomized controlled trials (RCTs)...
  44. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    Emelia Benjamin; Fiscal Year: 2009
    ..In this grant, we propose to pool data from five prospective studies in the US and Europe to validate in a more diverse population, the previous Framingham score for AF, and to ..
  45. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..In this grant, we propose to pool data from five prospective studies in the US and Europe to validate in a more diverse population, the previous Framingham score for AF, and to ..
  46. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven Spitalnik; Fiscal Year: 2009
    ..To this end, we propose carefully-controlled, prospective studies of healthy volunteers and patients with hemoglobinopathies...
  47. Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective Analysis
    A Heather Eliassen; Fiscal Year: 2010
    ..Specifically, 5 of 6 prospective studies of plasma carotenoids, including our own previous work in the Nurses'Health Study (NHS), found ..
  48. Oxidative Stree, Antioxidants and Risk of Breast Cancer: A Prospective Analysis
    A Heather Eliassen; Fiscal Year: 2009
    ..Specifically, 5 of 6 prospective studies of plasma carotenoids, including our own previous work in the Nurses'Health Study (NHS), found ..
  49. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    ..Because of their possible preventive potential, large-scale prospective studies are needed to clarify the issue of phytoestrogens and cancer...
  50. The Iowa Flood Study: Perinatal Effects of a Natural Disaster
    MICHAEL O HARA; Fiscal Year: 2009
    ..This in turn influences pregnancy outcomes and offspring development. To date, however, there have been no prospective studies of pregnant women exposed to a sudden-onset natural disaster that have been able to elucidate the ..
  51. Relation of Consummatory and Anticipatory Food Reward to Obesity
    Eric Stice; Fiscal Year: 2009
    ..Although twin studies imply that biological factors play a prominent role in the development of obesity, few prospective studies have identified biological factors that increase risk for future weight gain...
  52. Relation of Consummatory and Anticipatory Food Reward to Obesity
    ERIC M STICE; Fiscal Year: 2010
    ..Although twin studies imply that biological factors play a prominent role in the development of obesity, few prospective studies have identified biological factors that increase risk for future weight gain...
  53. Quantification of Regional Lung Disease by Computed Tomography
    Cuneyt Yilmaz; Fiscal Year: 2009
    ..chest CT in relation to lung pathology;they provide the essential data that may lead to future larger-scale prospective studies to test whether this approach accurately tracks or predicts longitudinal disease progression or response to ..
  54. Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in Hous
    Derek Cummings; Fiscal Year: 2009
    ..Though some prospective studies of influenza viruses have been conducted, little has been done to investigate the distribution of ..
  55. Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in Hous
    Derek Cummings; Fiscal Year: 2010
    ..Though some prospective studies of influenza viruses have been conducted, little has been done to investigate the distribution of ..
  56. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2003
    ..Project 2 focuses on the relationship between chronic sinusitis and asthma using prospective studies, analysis of the response to allergen or viral challenge, and detailed investigation of the relevance of ..
  57. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Project 2 focuses on the relationship between chronic sinusitis and asthma using prospective studies, analysis of the response to allergen or viral challenge, and detailed investigation of the relevance of ..
  58. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2002
    ..Project 2 focuses on the relationship between chronic sinusitis and asthma using prospective studies, analysis of the response to allergen or viral challenge, and detailed investigation of the relevance of ..
  59. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2004
    ..Project 2 focuses on the relationship between chronic sinusitis and asthma using prospective studies, analysis of the response to allergen or viral challenge, and detailed investigation of the relevance of ..
  60. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2001
    ..Project 2 focuses on the relationship between chronic sinusitis and asthma using prospective studies, analysis of the response to allergen or viral challenge, and detailed investigation of the relevance of ..
  61. Assisted Exercise in Prematurity: Effects and Mechanisms
    Dan Cooper; Fiscal Year: 2007
    ..However, prospective studies on assisted exercise have been limited in sample size and have not included a single set of anatomic and ..
  62. Assisted Exercise in Prematurity: Effects and Mechanisms
    Dan Cooper; Fiscal Year: 2005
    ..However, prospective studies on assisted exercise have been limited in sample size and have not included a single set of anatomic and ..
  63. Assisted Exercise in Prematurity: Effects and Mechanisms
    Dan Cooper; Fiscal Year: 2006
    ..However, prospective studies on assisted exercise have been limited in sample size and have not included a single set of anatomic and ..
  64. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..This hypothesis would take a long time to test in prospective studies, and retrospective assessment of prenatal exposure is bound to be seriously imprecise...
  65. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2006
    ..This hypothesis would take a long time to test in prospective studies, and retrospective assessment of prenatal exposure is bound to be seriously imprecise...
  66. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..This hypothesis would take a long time to test in prospective studies, and retrospective assessment of prenatal exposure is bound to be seriously imprecise...
  67. Depression & CHD: Cellular-Molecular Mechanisms
    EDWARD SUAREZ; Fiscal Year: 2009
    ..intervention be extended to target reduction in psychological, metabolic and inflammatory factors that in prospective studies have been shown to predict new cases of coronary heart disease (CHD)...
  68. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..However, recent prospective studies using serial measurements of kidney function estimated from serum cystatin C have changed this paradigm by ..
  69. Validity of Diet and Activity Measures in Women
    Walter Willett; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Large prospective studies of diet and cancer have often not supported hypotheses that were based on animal and ecological findings;one possible explanation could be large measurement errors in the ..
  70. Epidemiology and T cell response to cat allergen
    Thomas Platts Mills; Fiscal Year: 2001
    Description (provided by applicant): In case control and prospective studies, sensitization to one or more of the major indoor allergens, i.e. mite, cat, dog or cockroach, has been the most consistent risk factor for asthma...
  71. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2001
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  72. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2001
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-I to be associated with colorectal cancer risk...
  73. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2001
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  74. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2002
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  75. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2002
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  76. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2002
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  77. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2002
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  78. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2001
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  79. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  80. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-I to be associated with colorectal cancer risk...
  81. HIV Testing and Counseling in STD Clinics: an Adaptation of CTN 0032
    LISA R contact METSCH; Fiscal Year: 2010
    ..There have been no prospective studies since the implementation of rapid HIV testing in either health care or non-health care settings that have ..
  82. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  83. Pharmacogenomically Selected Treatment for Gastric and Gastroesophageal Junction
    ALBERT LOCKHART; Fiscal Year: 2007
    ..However, there have been no prospective studies in gastric and GEJ cancer evaluating the clinical utility of these genetic factors...
  84. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  85. HIV Testing and Counseling in STD Clinics: an Adaptation of CTN 0032
    Lisa Metsch; Fiscal Year: 2009
    ..There have been no prospective studies since the implementation of rapid HIV testing in either health care or non-health care settings that have ..
  86. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2002
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-I to be associated with colorectal cancer risk...
  87. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...