prospective studies

Summary

Summary: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Top Publications

  1. ncbi A modified poisson regression approach to prospective studies with binary data
    Guangyong Zou
    Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada
    Am J Epidemiol 159:702-6. 2004
  2. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
  3. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
  4. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
  5. ncbi Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 351:781-91. 2004
  6. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
  7. ncbi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
  8. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
  9. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
  10. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000

Detail Information

Publications339 found, 100 shown here

  1. ncbi A modified poisson regression approach to prospective studies with binary data
    Guangyong Zou
    Robarts Clinical Trials, Robarts Research Institute, London, Ontario, Canada
    Am J Epidemiol 159:702-6. 2004
    ..Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100. The method is illustrated with two data sets...
  2. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
    ..The influence of excess body weight on the risk of death from cancer has not been fully characterized...
  3. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
    ..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
  4. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  5. ncbi Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    Massimo Cristofanilli
    Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 351:781-91. 2004
    ..We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer...
  6. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    ..The aim of this study was to investigate whether these are related...
  7. ncbi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
    ..Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories...
  8. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
    ....
  9. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    ..To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages...
  10. ncbi Prospective study of the association between sleep-disordered breathing and hypertension
    P E Peppard
    Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705, USA
    N Engl J Med 342:1378-84. 2000
    ....
  11. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
  12. pmc Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
    I M Stratton
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 321:405-12. 2000
    ..To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes...
  13. ncbi Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    D H O'Leary
    Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
    N Engl J Med 340:14-22. 1999
    ..We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease...
  14. pmc Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 329:1212. 2004
    ..To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission...
  15. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    ..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
  16. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
    ..Adherence to a Mediterranean diet may improve longevity, but relevant data are limited...
  17. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
    ..Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors...
  18. ncbi Sedentary behaviors and health outcomes among adults: a systematic review of prospective studies
    Karin I Proper
    Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands
    Am J Prev Med 40:174-82. 2011
    ..To date, there is no review of prospective studies that systematically examined the relationship between diverse sedentary behaviors and various health ..
  19. ncbi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
    ....
  20. ncbi Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy
    Am J Clin Nutr 92:1189-96. 2010
    ..The Mediterranean diet has long been reported to be protective against the occurrence of several different health outcomes...
  21. pmc Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
    Paul E Ronksley
    Department of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada
    BMJ 342:d671. 2011
    ..To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes...
  22. ncbi Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Nicholas J Wareham
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Robinson Way, CB2 2SR, UK
    Public Health Nutr 6:407-13. 2003
    ....
  23. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  24. pmc Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
    Munir Pirmohamed
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE
    BMJ 329:15-9. 2004
    ..To ascertain the current burden of adverse drug reactions (ADRs) through a prospective analysis of all admissions to hospital...
  25. ncbi Sedentary behaviour and cardiovascular disease: a review of prospective studies
    Earl S Ford
    Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 41:1338-53. 2012
    ..7 h/day. Historically, sedentary behaviour was conceptualized as one end of the physical activity spectrum but is increasingly being viewed as a behaviour distinct from physical activity...
  26. pmc Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies
    Lu Wang
    Brigham and Women s Hospital, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 5:819-29. 2012
    ..Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear...
  27. pmc Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study
    W S Lim
    Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 58:377-82. 2003
    ..A multicentre study was conducted to derive and validate a practical severity assessment model for stratifying adults hospitalised with CAP into different management groups...
  28. ncbi The use of fractional polynomials to model continuous risk variables in epidemiology
    P Royston
    Department of Medical Statistics and Evaluation, Imperial College School of Medicine, London, UK
    Int J Epidemiol 28:964-74. 1999
    ..The traditional method of analysing continuous or ordinal risk factors by categorization or linear models may be improved...
  29. ncbi Decline in the AIDS and death rates in the EuroSIDA study: an observational study
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 362:22-9. 2003
    ..Since the introduction of highly active antiretroviral therapy (HAART), little is known about whether changes in HIV-1 mortality and morbidity rates have been sustained. We aimed to assess possible changes in these rates across Europe...
  30. ncbi Gait variability and fall risk in community-living older adults: a 1-year prospective study
    J M Hausdorff
    Gerontology Division, Beth Israel Deaconess Medical Center and Division on Aging, Harvard Medical School, Boston, MA 02215, USA
    Arch Phys Med Rehabil 82:1050-6. 2001
    ..To test the hypothesis that increased gait variability predicts falls among community-living older adults attending an outpatient clinic...
  31. pmc Use of archived specimens in evaluation of prognostic and predictive biomarkers
    Richard M Simon
    Biometric Research Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892 7434, USA
    J Natl Cancer Inst 101:1446-52. 2009
    ....
  32. pmc Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
    Pasquale Strazzullo
    Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy
    BMJ 339:b4567. 2009
    ..To assess the relation between the level of habitual salt intake and stroke or total cardiovascular disease outcome...
  33. pmc 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 168:1174-80. 2008
    ..Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans...
  34. ncbi Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults
    C R Brewin
    Subdepartment of Clinical Health Psychology, University College London, England
    J Consult Clin Psychol 68:748-66. 2000
    ....
  35. ncbi Hospital-acquired renal insufficiency
    Kevin Nash
    Evanston Hospital, Evanston, IL, USA
    Am J Kidney Dis 39:930-6. 2002
    ..There is a trend toward better survival in patients with a severe deterioration in renal function...
  36. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  37. ncbi Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...
  38. ncbi Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Am J Kidney Dis 58:374-82. 2011
    ..Whether low 25(OH)D levels in patients with CKD are an independent risk factor for mortality remains to be studied in detail, and this was the objective of our work...
  39. ncbi Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Cape Town, South Africa
    AIDS 19:2141-8. 2005
    ..To determine rates, risk factors and causes of death among patients accessing a community-based antiretroviral treatment (ART) programme both prior to and following initiation of treatment...
  40. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  41. pmc Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults
    Alpa V Patel
    Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA
    Am J Epidemiol 172:419-29. 2010
    ..The time spent sitting was independently associated with total mortality, regardless of physical activity level. Public health messages should include both being physically active and reducing time spent sitting...
  42. pmc Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, 1120 NW 14th St, Miami, FL 33136, USA
    JAMA 305:2432-9. 2011
    ....
  43. pmc Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea
    Blaise Genton
    Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 5:e127. 2008
    ..A large morbidity surveillance conducted in an area where the four species coexist allowed us to estimate rates of SM among patients infected with one or several species...
  44. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  45. ncbi Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
    Matthias Egger
    Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
    Lancet 360:119-29. 2002
    ..The ART Cohort Collaboration, which includes 13 cohort studies from Europe and North America, was established to fill this knowledge gap...
  46. ncbi Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    P M Ridker
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 101:1767-72. 2000
    ..Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse...
  47. ncbi Rosuvastatin and cardiovascular events in patients undergoing hemodialysis
    Bengt C Fellström
    Department of Medical Science, Renal Unit, University Hospital, SE 751 85, Uppsala, Sweden
    N Engl J Med 360:1395-407. 2009
    ..Statins reduce the incidence of cardiovascular events in patients at high cardiovascular risk. However, a benefit of statins in such patients who are undergoing hemodialysis has not been proved...
  48. ncbi Body-mass index and mortality in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    N Engl J Med 355:779-87. 2006
    ..Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial...
  49. ncbi What do we mean by validating a prognostic model?
    D G Altman
    ICRF Medical Statistics Group, Centre for Statistics in Medicine, Institute of Health Sciences, Old Road, Headington, Oxford OX3 7LF, UK
    Stat Med 19:453-73. 2000
    ..We illustrate the issues using several case studies...
  50. pmc Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies
    Francesco P Cappuccio
    University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, Coventry, UK
    Sleep 33:585-92. 2010
    ..Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes...
  51. pmc Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies
    Doris S M Chan
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
    PLoS ONE 6:e20456. 2011
    ..Since then, ten prospective studies have published new results...
  52. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    ..We examined the impact of MetS on CHD, CVD, and overall mortality among US adults...
  53. ncbi Validity of self-reported height and weight in 4808 EPIC-Oxford participants
    Elizabeth A Spencer
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
    Public Health Nutr 5:561-5. 2002
    ....
  54. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  55. ncbi Combination antiretroviral therapy and the risk of myocardial infarction
    Nina Friis-Møller
    N Engl J Med 349:1993-2003. 2003
    ..It remains controversial whether exposure to combination antiretroviral treatment increases the risk of myocardial infarction...
  56. ncbi European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection
    E Riboli
    Unit of Nutrition and Cancer, International Agency for Research on Cancer IARC WHO, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Public Health Nutr 5:1113-24. 2002
    ..The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort...
  57. ncbi Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies
    Lawrence de Koning
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Eur Heart J 28:850-6. 2007
    ....
  58. pmc Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study
    Julia Hippisley-Cox
    Tower Building, University Park, Nottingham NG2 7RD
    BMJ 335:136. 2007
    ..To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN)...
  59. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  60. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  61. ncbi Overweight and obesity as determinants of cardiovascular risk: the Framingham experience
    Peter W F Wilson
    Boston University School of Medicine, 715 Albany St, Evans 204, Boston, MA 02118, USA
    Arch Intern Med 162:1867-72. 2002
    ..To our knowledge, no single investigation concerning the long-term effects of overweight status on the risk for hypertension, hypercholesterolemia, diabetes mellitus, and cardiovascular sequelae has been reported...
  62. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
    ..We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease...
  63. ncbi Subclinical atrial fibrillation and the risk of stroke
    Jeff S Healey
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 366:120-9. 2012
    ..We evaluated whether subclinical episodes of rapid atrial rate detected by implanted devices were associated with an increased risk of ischemic stroke in patients who did not have other evidence of atrial fibrillation...
  64. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabák
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes...
  65. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    ..To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD)...
  66. ncbi Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system
    Sabine Riethdorf
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 13:920-8. 2007
    ..Here, we validated the analytic performance of this system for clinical use in patients with metastatic breast cancer...
  67. pmc Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study
    Daniel J Gottlieb
    VA Boston Healthcare System, and Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2394, USA
    Circulation 122:352-60. 2010
    ..The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women...
  68. ncbi Non-response and related factors in a nation-wide health survey
    K Korkeila
    Department of General Practice, University of Turku, Finland
    Eur J Epidemiol 17:991-9. 2001
    ..To analyse selective factors associated with an unexpectedly low response rate...
  69. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  70. ncbi Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    George Ostapowicz
    Department of Medicine, Gold Coast Hospital, 108 Nerang Street, Southport, QLD 4215, Australia
    Ann Intern Med 137:947-54. 2002
    ..Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition...
  71. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  72. ncbi The incidence and severity of adverse events affecting patients after discharge from the hospital
    Alan J Forster
    University of Ottawa, F654 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Ann Intern Med 138:161-7. 2003
    ..Studies of hospitalized patients identify safety as a significant problem, but few data are available regarding injuries occurring after discharge. Patients may be vulnerable during this transition period...
  73. ncbi Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission
    Ellen R Cooper
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, 774 Albany Street, Suite 506, Boston, MA 02118, U S A
    J Acquir Immune Defic Syndr 29:484-94. 2002
    ..The Women and Infants Transmission Study is a prospective natural history study that has been enrolling HIV-1-infected pregnant women and their infants since 1989...
  74. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  75. pmc Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores
    Julia Hippisley-Cox
    Division of Primary Care, Tower Building, University Park, Nottingham NG2 7RD
    BMJ 339:b4229. 2009
    ..To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years...
  76. ncbi Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
    ..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
  77. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    ..60 to 1.00 (34% [115] of all patients). INTERPRETATION: A combination of basic serum markers could be used to substantially reduce the number of liver biopsies done in patients with chronic HCV infection...
  78. ncbi An algorithm for tuberculosis screening and diagnosis in people with HIV
    Kevin P Cain
    U S Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, Atlanta, GA 30333, USA
    N Engl J Med 362:707-16. 2010
    ..No internationally accepted, evidence-based guideline addresses the optimal means of conducting such screening, although screening for chronic cough is common...
  79. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  80. pmc Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis
    Patrice Carter
    Diabetes Research, Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW
    BMJ 341:c4229. 2010
    ..To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes...
  81. pmc The Rotterdam Study: 2010 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam The Netherlands
    Eur J Epidemiol 24:553-72. 2009
    ..epib.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  82. ncbi Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies
    K J Anstey
    Ageing Research Unit, Centre for Mental Health Research Medical School, Australian National University, Canberra, ACT, Australia
    Obes Rev 12:e426-37. 2011
    ..in midlife and late-life) and dementia was investigated in meta-analyses of 16 articles reporting on 15 prospective studies. Follow-ups ranged from 3.2 to 36.0 years...
  83. ncbi Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial
    Richard R Riker
    University of Vermont College of Medicine, USA
    JAMA 301:489-99. 2009
    ..Gamma-aminobutyric acid receptor agonist medications are the most commonly used sedatives for intensive care unit (ICU) patients, yet preliminary evidence indicates that the alpha(2) agonist dexmedetomidine may have distinct advantages...
  84. ncbi Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    Hilmar Wisplinghoff
    Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA
    Clin Infect Dis 39:309-17. 2004
    ..Nosocomial bloodstream infections (BSIs) are important causes of morbidity and mortality in the United States...
  85. pmc Rapid DNA methylation changes after exposure to traffic particles
    Andrea Baccarelli
    Laboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Am J Respir Crit Care Med 179:572-8. 2009
    ..Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis...
  86. ncbi Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)
    Amanda I Adler
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, and South Cleveland Hospital, Cleveland, United Kingdom
    Kidney Int 63:225-32. 2003
    ..This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death...
  87. ncbi Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies
    Kaarin J Anstey
    Centre for Mental Health Research, School of Psychology, The Australian National University, Canberra, Australia
    Am J Epidemiol 166:367-78. 2007
    The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up...
  88. ncbi Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  89. ncbi C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    ..Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events...
  90. pmc Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk
    Jane Green
    Cancer Epidemiology Unit, University of Oxford, UK
    Lancet Oncol 12:785-94. 2011
    ....
  91. ncbi Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerp, Belgium manu malbrain skynet be
    Intensive Care Med 30:822-9. 2004
    ..This study assessed the prevalence of IAH and its risk factors in a mixed population of intensive care patients...
  92. doi Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascula
    James H Stein
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
  93. ncbi The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)
    Elaine Thomas
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    Pain 110:361-8. 2004
    ..More importantly the extent to which pain interferes with everyday life increases incrementally with age up to the oldest age-group in the community-dwelling general population...
  94. ncbi Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
    Stavros N Karamanakos
    Nutrition Support and Morbid Obesity Unit, Department of Surgery, University of Patras School of Medicine, Patras, Greece
    Ann Surg 247:401-7. 2008
    ..Bariatric surgery is currently the most effective treatment in morbidly obese patients, leading to durable weight loss...
  95. ncbi Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:506-11. 2010
    ..The objective of the present study was to evaluate the safety of withholding antimalarials in febrile children who have a negative test result...
  96. pmc Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
    Alexander Thompson
    Lp PLA2 Studies Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:1536-44. 2010
    ..We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances...
  97. ncbi Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study
    J R Ickovics
    Yale University, Department of Epidemiology and Public Health, PO Box 208034, 60 College St, Suite 415, New Haven, CT 06520 8034, USA
    JAMA 285:1466-74. 2001
    ..The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts...
  98. pmc Risk factors of influenza transmission in households
    Cecile Viboud
    Epidemiology and Information Sciences, Universite Pierre et Marie Curie, Paris
    Br J Gen Pract 54:684-9. 2004
    ..Influenza transmission in households is a subject of renewed interest, as the vaccination of children is currently under debate and antiviral treatments have been approved for prophylactic use...
  99. ncbi A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    Fred A Zar
    University of Illinois at Chicago, Chicago, IL 60612 7323, USA
    Clin Infect Dis 45:302-7. 2007
    ..We conducted such a trial, stratifying patients according to disease severity, to investigate whether one agent was superior for treating either mild or severe disease...
  100. pmc Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review
    Jeroen S L de Munter
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e261. 2007
    ..We evaluated intakes of whole grain, bran, and germ in relation to risk of type 2 diabetes in prospective cohort studies...
  101. ncbi Sexual behavior of HIV discordant couples after HIV counseling and testing
    Susan Allen
    Department of Epidemiology and International Health, School of Public Health, University of Alabama in Birmingham, 35294, USA
    AIDS 17:733-40. 2003
    ..Biological markers were used to assess the validity of self-report...

Research Grants76

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Our program focuses on prospective studies to prevent and improve the diagnosis and treatment of complications5, 25, 44-53...
  2. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  3. Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis
    Shervin Assassi; Fiscal Year: 2013
    ..of predictive biomarkers in rheumatic diseases and examination of their clinical usefulness in prospective studies. Proposed Research: SSc is associated with substantial morbidity and mortality...
  4. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..This investigation includes community based cohort studies (prospective studies), active surveillance using temporal cross-sectional studies, and hospital based passive surveillance ..
  5. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..These include: the NCI Breast and Prostate Cancer Cohort Consortium (BPC3), the Pooling Project of Prospective Studies of Diet and Cancer, and the Harvard Specialized Center on Folate, One-Carbon Nutrients, Gene Variants and ..
  6. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..Project 3 pools data from 21 major prospective studies of diet and cancer...
  7. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..Novel therapies to complement these interventions are urgently needed. Mounting evidence from prospective studies indicates that moderately elevated serum uric acid is a strong, independent predictor of an increased risk ..
  8. Comparative Effectiveness Research in Pediatric Rheumatic Diseases: Leveraging CA
    CAROL A contact WALLACE; Fiscal Year: 2010
    ..and Rheumatology Research Alliance (CARRA) has created the opportunities multi-center retrospective and prospective studies of high impact...
  9. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..as the associations between plasma Apo A-1 and Apo B100 and cancer risk are largely unexplored in prospective studies. Few studies have examined blood lipid markers and long-term statin use in relation to endometrial cancer ..
  10. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..Novel therapies to complement these interventions are urgently needed. Mounting evidence from prospective studies indicates that moderately elevated serum uric acid is a strong, independent predictor of an increased risk ..
  11. Assessment of Dehydration in Children with Diarrhea in Resource-Limited Settings
    ADAM CARL LEVINE; Fiscal Year: 2013
    ..I will also benefit from the additional experience of managing large, prospective studies under the mentorship of three scientists with extensive experience in conducting public health and global ..
  12. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..Recent cross-sectional studies link the syndrome to higher periodontal disease prevalence. Prospective studies are needed to further understand the relationship between metabolic syndrome and periodontal disease...
  13. Innate immunity predictors of HIV: the role of contraception, pregnancy and HSV-2
    Charles Morrison; Fiscal Year: 2013
    ..COCs), and pregnancy have been associated with increased risk of HIV in some, but not all, large prospective studies. In February 2012, due to the conflicting epidemiologic study results and lack of sufficient mechanistic ..
  14. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..it builds on the proven method and findings of previous grant cycles to integrate passive surveillance and prospective studies in the community...
  15. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..Novel therapies to complement these interventions are urgently needed. Mounting evidence from prospective studies indicates that moderately elevated serum uric acid is a strong, independent predictor of an increased risk ..
  16. Measuring Tobacco Mortality within the Million Death Study in India
    Prabhat Jha; Fiscal Year: 2010
    ..This project (among the world's largest prospective studies of adult health) is possible because of the success of our earlier NIH grant (#TW005991) which established ..
  17. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2012
    ..evaluate pre-diagnostic genomic methylation of leukocyte DNA in relation to colorectal cancer risk in large prospective studies and expect that individuals with reduced levels of genomic DNA methylation are at increased risk of ..
  18. Depression &CHD: Cellular-Molecular Mechanisms
    EDWARD CARLOS SUAREZ; Fiscal Year: 2013
    ..intervention be extended to target reduction in psychological, metabolic and inflammatory factors that in prospective studies have been shown to predict new cases of coronary heart disease (CHD)...
  19. Chemoprevention of Prostate Cancer
    SUSAN AUDREY HALL; Fiscal Year: 2012
    ..In four large prospective studies, statins were found to reduce the risk of advanced but not overall prCA...
  20. Study of Energy and Aging
    Steven Cummings; Fiscal Year: 2009
    ..value of novel measurements and developing them for hi-throughput use in this and future multicenter and prospective studies. The SEA database and specimen bank can be used to explore other factors that may contribute to impaired ..
  21. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..However, recent prospective studies using serial measurements of kidney function estimated from serum cystatin C have changed this paradigm by ..
  22. Harmful effects of transfusion of older stored red cells: iron and inflammation
    Steven L Spitalnik; Fiscal Year: 2012
    ..To this end, we propose carefully-controlled, prospective studies of healthy volunteers and patients with hemoglobinopathies...
  23. Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    HUGO RAMON ROSEN; Fiscal Year: 2013
    ..Detailed prospective studies of acute and evolving HCV infection are required to delineate the role of escape mutations in HCV ..
  24. The Effects of Lung Transplant on Disability and Health-Related Quality of Life
    Jonathan Paul Singer; Fiscal Year: 2013
    ..These goals include (1) the design and implementation of prospective studies with multiple waves of data;(2) advanced quantitative methods including repeated measures analysis to best ..
  25. Metabolic Effects of In Utero Antiretrovirals on HIV Exposed Uninfected Infants
    Jennifer Jao; Fiscal Year: 2013
    ..funded researcher who will lead multi-disciplinary teams in designing, implementing, and analyzing prospective studies of HIV-infected pregnant women and children to evaluate a variety of long term health outcomes following in ..
  26. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..In this grant, we propose to pool data from five prospective studies in the US and Europe to validate in a more diverse population, the previous Framingham score for AF, and to ..
  27. Benaroya Research Institute/UCDHSC Autoimmune Cooperative Study Group
    George S Eisenbarth; Fiscal Year: 2011
    ..During the current grant our joint Center has initiated DAISY like prospective studies of rheumatoid arthritis, initiated a program to obtain pancreas from islet autoantibody cadaveric donors (a ..
  28. Validity of Diet and Activity Measures in Men
    Meir Stampfer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Large prospective studies of diet and cancer have often not supported hypotheses that were based on animal and ecological findings;one possible explanation could be large measurement errors in the ..
  29. Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in Hous
    Derek Cummings; Fiscal Year: 2011
    ..Though some prospective studies of influenza viruses have been conducted, little has been done to investigate the distribution of ..
  30. Telomere Attrition Rate and Periodontitis: a nested case control study in the ARI
    ANNE ELIZABETH SANDERS; Fiscal Year: 2013
    ..To date, few prospective studies have measured rates of telomere attrition over time and even fewer of these have compared telomere ..
  31. Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH)
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..Two recent prospective studies (20 mothers from U.S...
  32. Prospective Study of Restless Leg Syndrome
    Xiang Gao; Fiscal Year: 2011
    ..Particularly, there is a need of further large prospective studies on the clinical impact of RLS given a high prevalence of the syndrome...
  33. Investigations of the optimum serum bicarbonate level in renal disease
    KALANI LUKELA RAPHAEL; Fiscal Year: 2013
    ..goals are to develop skills in clinical research by conducting retrospective, cross-sectional, and prospective studies in humans and to begin to achieve expertise in the area of acid-base management in renal disease...
  34. COX Inhibition & Musculoskeletal Responses to Exercise
    Wendy M Kohrt; Fiscal Year: 2010
    ..There have been no prospective studies in humans of the potential effects of NSAIDs to impair the anabolic actions of exercise on bone and muscle...
  35. HPV &Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2013
    ..Specifically, using immunohistochemistry we will conduct one of the few prospective studies of the immune infiltrates that distinguish (a) CIN-1 that regress vs progress to CIN-2+, and (b) CIN ..
  36. Relation of Consummatory and Anticipatory Food Reward to Obesity
    Sonja Yokum; Fiscal Year: 2013
    ..Although twin studies imply that biological factors play a prominent role in the development of obesity, few prospective studies have identified biological factors that increase risk for future weight gain...
  37. Prospective evaluation of IGF and IL-6 Dysregulation and Multiple Myeloma
    Graham A Colditz; Fiscal Year: 2010
    ..Thus, prospective studies are needed to characterize the etiology of MM to inform the development of prevention strategies...
  38. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..This study will be the largest among very few prospective studies to look at the impact of air pollution on fetal growth controlling for major confounding factors...
  39. Luteal Progesterone Supplementation in Clomiphene Citrate-IUI Cycles
    KARL RICHARD HANSEN; Fiscal Year: 2013
    ..Recent observational and small prospective studies have suggested that luteal phase progesterone supplementation may improve live-birth rates in women with ..
  40. Primary Immune Deficiency Treatment Consortium Annual Scientific Meeting
    Luigi Daniele Notarangelo; Fiscal Year: 2013
    ..with the goal of building a nation-wide collaboration to carry-out retrospective, cross-sectional and prospective studies that would define risk factors, long term outcomes and late effects in children with Severe Combined ..
  41. Empirical eating disorder classification and validation using prospective studies
    Nadia Micali; Fiscal Year: 2013
    ..We propose to use the two largest prospective studies with frequent assessments of disordered eating during adolescence and young adulthood to empirically derive ..
  42. The Iowa Flood Study: Perinatal Effects of a Natural Disaster
    MICHAEL WILLIAM O apos HARA; Fiscal Year: 2010
    ..This in turn influences pregnancy outcomes and offspring development. To date, however, there have been no prospective studies of pregnant women exposed to a sudden-onset natural disaster that have been able to elucidate the ..
  43. Longtitudinal Study of Dialysis
    Rulan S Parekh; Fiscal Year: 2012
    ..leading to CVD morbidity and mortality in the dialysis population;however, there have been few large scale prospective studies. The overall objective of this proposal is to study novel vascular calcification risk factors for ..
  44. Serum microRNA signature as prospective HCC biomarker in HBV patients
    Hushan Yang; Fiscal Year: 2012
    ..This makes serum a valuable resource for miRNA- based biomarker research, especially in prospective studies that have been followed-up for extended time periods but only collected serum samples at the time of study ..
  45. Lactation and Glucose Tolerance After GDM Pregnancy
    ERICA PAULINE GUNDERSON; Fiscal Year: 2011
    ..never), current status (yes vs. no), or lifetime months of lactation. No prospective studies have assessed lactation intensity (supplemental feedings) and/or duration in relation to development of ..
  46. Epidemiology of Patellofemoral Pain Syndrome: Identifying Gender Specific Risk Fa
    MICHELLE CLARA BOLING; Fiscal Year: 2011
    ..Our rationale for the proposed investigation is that there is a crucial need for prospective studies that identify the risk factors for PFP so that more focused prevention strategies can be developed that are ..
  47. Lipoproteins and PEDF in the Vascular Complications of Diabetes
    Timothy J Lyons; Fiscal Year: 2010
    ..This work, which involves ongoing collaboration with two large federally funded prospective studies of Type 1 and of Type 2 diabetes, addresses markers and mechanisms for the chronic vascular complications ..
  48. Retrospective Assessment of Military Occupations &Neurodegenerative Diseases
    Lorene M Nelson; Fiscal Year: 2011
    ..Since prospective studies of neurodegenerative diseases such as ALS and PD which have a late age of onset are not usually feasible, ..
  49. Pooling of Prospective Studies of Diet, Lifestyle and ALS
    EILIS O'REILLY; Fiscal Year: 2013
    ..of amyotrophic lateral sclerosis (ALS), we propose to pool the primary data of the Pooling Project of Prospective Studies of Diet and Cancer (Cancer Pooling Project), an international consortium of 28 cohort studies...
  50. Biomarkers of Obesity, Prostate Tissue Inflammation, and BPH Progression
    Jay H Fowke; Fiscal Year: 2013
    ..Several prior prospective studies report obesity is associated with clinical symptoms of benign prostatic hyperplasia (BPH)...
  51. Cognitive and socioemotional development after postnatal anesthesia
    Mark G Baxter; Fiscal Year: 2013
    ..development, but it is not possible to address this question directly in humans because randomized prospective studies are not possible and retrospective (observational) studies are subject to serious confounds: for example, ..
  52. Acid-base status and the development of hypertension and diabetes
    Eric N Taylor; Fiscal Year: 2012
    ..acid-base status and the subsequent risk of hypertension and type 2 diabetes, we propose the following prospective studies of women in NHS I and II: 1) a nested case-control study of the association between plasma bicarbonate and ..
  53. Natural History of Urban Leptospirosis
    Albert Icksang Ko; Fiscal Year: 2013
    ..A major barrier to identifying interventions has been the lack of prospective studies on leptospirosis...
  54. GLUTATHIONE, OXIDATIVE STRESS, AND AGING
    William C Orr; Fiscal Year: 2010
    ..Results of the prospective studies would directly test the predictions of the oxidative stress hypothesis of aging and indicate whether ..
  55. Epigenetic predicators of asthma in neonates
    Donata Vercelli; Fiscal Year: 2010
    ..will be considered as bona fide neonatal epigenetic predictors of asthma, and will be proposed for future prospective studies. PUBLIC HEALTH RELEVANCE: This application addresses broad Challenge Area (03) Biomarker discovery and ..
  56. Assessing feeding practices, immune activation, and HIV risk in African infants
    HEATHER BERYL JASPAN; Fiscal Year: 2013
    ..Multiple observational, prospective studies have shown that exclusive breastfeeding (EBF) reduces the risk of mother-to-child- transmission (MTCT) two ..
  57. Clinical Trial Planning Grant in Catheter-Directed Thrombolysis of Occlusive DVT
    Marilyn J Manco-Johnson; Fiscal Year: 2013
    ..The strongest prognostic factors for PTS identified in prospective studies were use of thrombolysis and related thrombus resolution...
  58. Sociocultural Factors and Cardiometabolic Risk in Mexican-American Women
    Linda C Gallo; Fiscal Year: 2013
    ..Very few prospective studies have examined SES, psychosocial and behavioral factors, and cardiometabolic risk progression over time, ..
  59. Alcohol Consumption and Risk of Rheumatoid Arthritis in Women
    Bing Lu; Fiscal Year: 2011
    ..However, definitive data supporting this association from well-controlled prospective studies are lacking...
  60. Prospective Studies of Avian Influenza Transmission in Asia
    GREGORY CHARLES GRAY; Fiscal Year: 2010
    ..This study is innovative in that no such prospective studies of avian influenza infection have been performed among those person's occupationally exposed to ..
  61. THE IMMUNOBIOLOGY OF CORNEAL ALLOGRAFTS
    Jerry Niederkorn; Fiscal Year: 2013
    ..A mouse model of penetrating keratoplasty will be used in prospective studies that address three specific aims pursuant to these long range goals...
  62. Incidence and Natural History of Hepatitis E Virus in Pregnant Bangladeshi Women
    ALAIN BERNARD LABRIQUE; Fiscal Year: 2010
    ..There have been few rigorous, population-based, prospective studies of HEV incidence, immunopathogenesis and natural history among pregnant women...
  63. Randomized Trial/Reduce Recurrence/Bacterial Vaginosis
    King Holmes; Fiscal Year: 2004
    ..of reproductive ages, has been linked to female HIV-1 acquisition and infection in both cross sectional and prospective studies. Women in sub-Saharan Africa have the highest prevalence of BV, approximately 40-50 percent in Uganda and ..
  64. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..b>Prospective studies have found that women with elevated plasma homocysteine have a substantially increased risk of osteoporotic ..
  65. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..However, no prospective studies have been done to verify these findings...
  66. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    ..duration has been shown to be associated with an increased risk for hypertension incidence, but previous prospective studies on this association did not examine the potential effect modifiers of menopausal status, hormone ..
  67. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ..This registry will provide a foundation for rigorous prospective studies including large, practical, randomized controlled trials (RCTs)...
  68. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    ..Because of their possible preventive potential, large-scale prospective studies are needed to clarify the issue of phytoestrogens and cancer...
  69. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Project 2 focuses on the relationship between chronic sinusitis and asthma using prospective studies, analysis of the response to allergen or viral challenge, and detailed investigation of the relevance of ..
  70. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..This hypothesis would take a long time to test in prospective studies, and retrospective assessment of prenatal exposure is bound to be seriously imprecise...
  71. HIV Testing and Counseling in STD Clinics: an Adaptation of CTN 0032
    LISA R contact METSCH; Fiscal Year: 2010
    ..There have been no prospective studies since the implementation of rapid HIV testing in either health care or non-health care settings that have ..
  72. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  73. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-I to be associated with colorectal cancer risk...
  74. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  75. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...
  76. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..risk factors for colorectal neoplasia are similar to those for insulin resistance syndromes, and prospective studies have shown both diabetes and higher levels of IGF-1 to be associated with colorectal cancer risk...