double blind method

Summary

Summary: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

Top Publications

  1. ncbi Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    Stanley B Cohen
    Radiant Research, Dallas, Texas 75235, USA
    Arthritis Rheum 54:2793-806. 2006
  2. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
  3. ncbi Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
    Thomas Baumgartner
    Center for the Study of Social and Neural Systems, Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Neuron 58:639-50. 2008
  4. pmc Effectiveness of cellulose sulfate vaginal gel for the prevention of HIV infection: results of a Phase III trial in Nigeria
    Vera Halpern
    Family Health International, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 3:e3784. 2008
  5. ncbi Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
  6. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
  7. ncbi Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Lancet 352:609-13. 1998
  8. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
  9. ncbi Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
  10. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001

Detail Information

Publications282 found, 100 shown here

  1. ncbi Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    Stanley B Cohen
    Radiant Research, Dallas, Texas 75235, USA
    Arthritis Rheum 54:2793-806. 2006
    ....
  2. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
    ..The neuropeptide oxytocin plays a central role in social approach behavior in nonhuman mammals...
  3. ncbi Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
    Thomas Baumgartner
    Center for the Study of Social and Neural Systems, Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Neuron 58:639-50. 2008
    ..These findings may help to develop deeper insights into mental disorders such as social phobia and autism, which are characterized by persistent fear or avoidance of social interactions...
  4. pmc Effectiveness of cellulose sulfate vaginal gel for the prevention of HIV infection: results of a Phase III trial in Nigeria
    Vera Halpern
    Family Health International, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 3:e3784. 2008
    ..This trial evaluated the safety and effectiveness of 6% cellulose sulfate vaginal gel in preventing male-to-female vaginal transmission of HIV, gonorrhea and chlamydial infection...
  5. ncbi Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
    ..Accordingly, the double-blind, placebo-controlled, randomized German Multicenter EPO Stroke Trial (Phase II/III; ClinicalTrials.gov Identifier: NCT00604630) was designed to evaluate efficacy and safety of EPO in stroke...
  6. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    ..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
  7. ncbi Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Lancet 352:609-13. 1998
    ..We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs)...
  8. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
    ..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
  9. ncbi Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  10. ncbi Ghrelin enhances appetite and increases food intake in humans
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 86:5992. 2001
    ..Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man. Endogenous ghrelin is a potentially important new regulator of the complex systems controlling food intake and body weight...
  11. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  12. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
    ..CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes...
  13. pmc Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    W Kruis
    Evangelisches Krankenhaus Kalk, University of Cologne, Germany
    Gut 53:1617-23. 2004
    ..We compared the efficacy in maintaining remission of the probiotic preparation Escherichia coli Nissle 1917 and established therapy with mesalazine in patients with ulcerative colitis...
  14. ncbi A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea
    Blaise Genton
    Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    J Infect Dis 185:820-7. 2002
    ..The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types...
  15. ncbi Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
    JAMA 292:1307-16. 2004
    ..Limited data are available evaluating how the timing and intensity of statin therapy following an acute coronary syndrome (ACS) event affect clinical outcome...
  16. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    ..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
  17. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  18. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  19. pmc Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
    Michele D Spring
    United States Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 4:e5254. 2009
    ....
  20. ncbi Impact of preventing exacerbations on deterioration of health status in COPD
    S Spencer
    Dept of Health and Social Care, Brunel University, Isleworth, UK
    Eur Respir J 23:698-702. 2004
    ..Statistical modelling showed the beneficial effect of fluticasone propionate on deterioration in health status to be largely due to its effect on exacerbation frequency...
  21. pmc Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial
    J Smolen
    Department of Internal Medicine III, Medical University of Vienna and 2nd Department of Medicine, Hietzing Hospital, Austria
    Ann Rheum Dis 68:797-804. 2009
    ..Certolizumab pegol is a PEGylated tumour necrosis factor inhibitor...
  22. ncbi Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial
    Nancy R Cook
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    JAMA 294:47-55. 2005
    ..Basic research and observational evidence as well as results from trials of colon polyp recurrence suggest a role for aspirin in the chemoprevention of cancer...
  23. ncbi Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial
    Helen M Colhoun
    EURODIAB, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Lancet 364:685-96. 2004
    ..We aimed to assess the effectiveness of atorvastatin 10 mg daily for primary prevention of major cardiovascular events in patients with type 2 diabetes without high concentrations of LDL-cholesterol...
  24. ncbi Blinding in randomised trials: hiding who got what
    Kenneth F Schulz
    Family Health International, PO Box 13950, Research Triangle Park, NC 27709, USA
    Lancet 359:696-700. 2002
    ..Unfortunately, many articles do not contain proper reporting. If an article claims blinding without any accompanying clarification, readers should remain sceptical about its effect on bias reduction...
  25. ncbi Acute administration of d-amphetamine decreases impulsivity in healthy volunteers
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 27:813-25. 2002
    ..These results suggest that acute doses of amphetamine decrease several forms of impulsive behavior. These findings extend and confirm previous findings in humans and laboratory animals...
  26. ncbi Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer
    F A Holmes
    Texas Oncology, PA, Dallas, TX
    J Clin Oncol 20:727-31. 2002
    ....
  27. ncbi Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    Henning Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 21:2101-9. 2003
    ..To analyze overall survival (OS) and update efficacy data for letrozole versus tamoxifen as first-line therapy in postmenopausal women with locally advanced or metastatic breast cancer...
  28. ncbi Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
    Josef S Smolen
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Lancet 371:987-97. 2008
    ..Our aim was to assess the therapeutic effects of blocking interleukin 6 by inhibition of the interleukin-6 receptor with tocilizumab in patients with rheumatoid arthritis...
  29. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  30. ncbi The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 345:870-8. 2001
    ..02). CONCLUSIONS: Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria...
  31. pmc A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali
    Issaka Sagara
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry BP 1805 Bamako, University of Bamako, Mali, Malaysia
    Vaccine 27:3090-8. 2009
    ..5 g/dL, in the direction of lower hemoglobin in the children who received AMA1-C1, although these differences were not significant after correction for multiple tests. These differences were not seen in the second year of transmission...
  32. pmc Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    Philip Bejon
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    N Engl J Med 359:2521-32. 2008
    ..We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children 5 to 17 months of age, a target population for vaccine licensure...
  33. ncbi A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Ganesh Raghu
    Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
    N Engl J Med 350:125-33. 2004
    ..Idiopathic pulmonary fibrosis is a progressive, fatal disease with no known efficacious therapy...
  34. ncbi Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study
    Nunziata Morabito
    Department of Internal Medicine, University of Messina, Italy
    J Bone Miner Res 17:1904-12. 2002
    ....
  35. ncbi The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4 R Postbox 9600, Leiden 2300 RC, The Netherlands
    Arthritis Rheum 54:26-37. 2006
    ..To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive rheumatoid arthritis (RA) who had not previously received MTX treatment...
  36. ncbi Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
    A Keech
    Lancet 366:1849-61. 2005
    ..We designed the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study to assess the effect of fenofibrate on cardiovascular disease events in these patients...
  37. ncbi Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases
    Suzanne M Garland
    Microbiology and Infectious Diseases Department, Royal Women s Hospital, and the University of Melbourne, Melbourne, Australia
    N Engl J Med 356:1928-43. 2007
    ..A phase 3 trial was conducted to evaluate the efficacy of a prophylactic quadrivalent vaccine in preventing anogenital diseases associated with human papillomavirus (HPV) types 6, 11, 16, and 18...
  38. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  39. ncbi Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial
    Hans Christoph Diener
    Department of Neurology, University Essen, Essen, Germany
    Lancet Neurol 5:310-6. 2006
    ....
  40. ncbi Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention
    Scott D Solomon
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 352:1071-80. 2005
    ..Experimental research suggesting that these drugs may contribute to a prothrombotic state provides support for this concern...
  41. ncbi Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    Emanuele Bosi
    Diabetes and Endocrinology Unit, Department of General Medicine, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Diabetes Care 30:890-5. 2007
    ..We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes...
  42. ncbi Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
    Bjorn Dahlof
    Sahlgrenska University Hospital Ostra, Gothenburg, Swede
    Lancet 359:995-1003. 2002
    ..We aimed to establish whether selective blocking of angiotensin II improves LVH beyond reducing blood pressure and, consequently, reduces cardiovascular morbidity and death...
  43. ncbi Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  44. ncbi Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    S Hulley
    University of California, San Francisco 94143, USA
    JAMA 280:605-13. 1998
    ..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue...
  45. ncbi Effects of pulsed electromagnetic fields on patients' recovery after arthroscopic surgery: prospective, randomized and double-blind study
    C Zorzi
    Sacro Cuore Don Calabria Hospital, Via don A Sempreboni 5, 37024 Negrar Vr, Italy
    Knee Surg Sports Traumatol Arthrosc 15:830-4. 2007
    ..05). Treatment with I-ONE aided patient recovery after arthroscopic surgery, reduced the use of NSAIDs, and also had a positive long-term effect...
  46. ncbi NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study
    Miroslav Backonja
    University of Wisconsin Madison, Madison, WI 53792, USA
    Lancet Neurol 7:1106-12. 2008
    ..We report the results of a randomised, double blind, 12-week study of the efficacy and safety of one application of NGX-4010 in patients with PHN...
  47. ncbi Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial
    David Osrin
    International Perinatal Care Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Lancet 365:955-62. 2005
    ..We tested the hypotheses that antenatal multiple micronutrient supplementation would increase infant birthweight and gestational duration...
  48. ncbi Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents
    Zvi Weizman
    Pediatric Gastroenterology and Nutrition Unit, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
    Pediatrics 115:5-9. 2005
    ..To investigate the effect of 2 different species of probiotics in preventing infections in infants attending child care centers...
  49. ncbi Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis
    Erasmo Miele
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    Am J Gastroenterol 104:437-43. 2009
    ....
  50. ncbi Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
    Kenneth Jamerson
    Division of Cardiovascular Medicine, University of Michigan Health System, 24 Frank Lloyd Wright Dr, Lobby M, Ann Arbor, MI 48106, USA
    N Engl J Med 359:2417-28. 2008
    ....
  51. ncbi Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    Peter Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 361:449-56. 2003
    ..We postulated that a combination of these treatments would be better than each component used alone...
  52. ncbi Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 19:633-9. 2005
    ..Methylphenidate did not affect memory or mood at any time of testing. A single dose of MDMA produces transient memory impairment...
  53. ncbi Sertraline treatment of major depression in patients with acute MI or unstable angina
    Alexander H Glassman
    Department of Clinical Psychopharmacology, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 116, New York, NY 10032, USA
    JAMA 288:701-9. 2002
    ..However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease...
  54. ncbi Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection
    Kent E Kester
    Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    J Infect Dis 200:337-46. 2009
    ..To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals)...
  55. ncbi Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial
    Norihiro Nishimoto
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, Suita City, Osaka, Japan
    Arthritis Rheum 50:1761-9. 2004
    ..This study was undertaken to evaluate the safety and efficacy of a humanized anti-IL-6 receptor antibody, MRA, in patients with RA...
  56. ncbi Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial
    F H Comhaire
    Ghent University Hospital, Department of Medical and Urological Andrology, 9k12 IE, De Pintelaan, 185, B 9000, Gent, Belgium
    Asian J Androl 7:257-62. 2005
    ..To evaluate the treatment of male infertility with a strong natural antioxidant, in addition to conventional treatment...
  57. ncbi Impact of alternate definitions of fever resolution on the composite endpoint in clinical trials of empirical antifungal therapy for neutropenic patients with persistent fever: analysis of results from the Caspofungin Empirical Therapy Study
    B E de Pauw
    University Hospital St Radboud, Nijmegen, The Netherlands
    Transpl Infect Dis 8:31-7. 2006
    ..liposomal amphotericin B as empirical antifungal therapy for febrile neutropenic patients to determine the impact of varying definitions of fever resolution on response rates...
  58. ncbi Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial
    Kenneth C Kalunian
    University of California, Los Angeles School of Medicine, USA
    Arthritis Rheum 46:3251-8. 2002
    ..To evaluate the safety and efficacy of a humanized monoclonal antibody against CD154 (IDEC-131) in patients with active systemic lupus erythematosus (SLE)...
  59. pmc Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee
    Lorcan P McGarvey
    The Queen s University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK
    Thorax 62:411-5. 2007
    ..The primary outcome is all-cause mortality. Cause-specific mortality and deaths related to COPD are additional outcome measures, but systematic methods for ascertainment of these outcomes have not previously been described...
  60. ncbi Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study
    James Shepherd
    Department of Vascular Biochemistry, University of Glasgow, G31 2ER, UK
    Clin J Am Soc Nephrol 2:1131-9. 2007
    ..This subanalysis of the Treating to New Targets study investigated how intensive lipid lowering with 80 mg of atorvastatin affects renal function when compared with 10 mg in patients with coronary heart disease...
  61. ncbi Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer
    Marie Helene Mayrand
    Department of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Canada
    N Engl J Med 357:1579-88. 2007
    ..To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods...
  62. ncbi Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial
    Sophia Zoungas
    Department of Vascular Sciences and Medicine, Centre for Vascular Health, Monash University, Dandenong Hospital, Dandenong, Victoria, Australia
    J Am Coll Cardiol 47:1108-16. 2006
    ..The Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) aimed to establish whether high-dose folic acid would slow the progression of atherosclerosis and reduce cardiovascular events in patients with chronic renal failure (CRF)...
  63. ncbi Acute dopamine D(1) and D(2) receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects
    Sumie Leung
    Biological Psychiatry Research Unit, Brain Sciences Institute, Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Australia
    Psychopharmacology (Berl) 194:443-51. 2007
    ....
  64. ncbi Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
    Jonathon L Reay
    Human Cognitive Neuroscience Unit, Northumbria University, Newcastle upon Tyne, UK
    J Psychopharmacol 19:357-65. 2005
    ..05). Overall these data suggest that Panax ginseng can improve performance and subjective feelings of mental fatigue during sustained mental activity. This effect may be related to the acute gluco-regulatory properties of the extract...
  65. ncbi The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis
    Ross L Paterson
    Academic Unit of Anaesthesia and Intensive Care, University of Aberdeen, Scotland, UK
    Crit Care Med 31:2574-8. 2003
    ..In this pilot study we investigated the effect of N-acetylcysteine on nuclear factor-kappa B activation and circulating cytokine and adhesion molecules in patients with sepsis...
  66. ncbi Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study
    Herman A Cohen
    Pediatric and Adolescent Ambulatory Community Clinic, Petach Tikva, Israel
    Arch Pediatr Adolesc Med 158:217-21. 2004
    ..To evaluate the effectiveness and safety of a preparation containing echinacea, propolis, and vitamin C in the prevention of respiratory tract infections in children during a 12-week winter period...
  67. ncbi A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    Paul E Goss
    Division of Hematology Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    N Engl J Med 349:1793-802. 2003
    ..The aromatase inhibitor letrozole, by suppressing estrogen production, might improve the outcome after the discontinuation of tamoxifen therapy...
  68. ncbi Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy
    C Peter N Watson
    University of Toronto, Toronto, ON, Canada
    Pain 105:71-8. 2003
    ..Painful neuropathy is one of the most common long-term complications of diabetes mellitus and often proves difficult to relieve...
  69. ncbi Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  70. ncbi Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)
    Paul Harmatz
    Pediatric Clinical Research Center, Children s Hospital and Research Center at Oakland, California 94606, USA
    J Pediatr 144:574-80. 2004
    ..To evaluate the safety and efficacy of weekly treatment with human recombinant N-acetylgalactosamine 4-sulfatase (rhASB) in humans with mucopolysaccharidosis type VI (MPS VI)...
  71. ncbi The perindopril in elderly people with chronic heart failure (PEP-CHF) study
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur Heart J 27:2338-45. 2006
    ..Few substantial randomized controlled trials have been conducted in this population, none has focussed on patients with evidence of diastolic dysfunction and none has shown clear benefit on symptoms, morbidity, or mortality...
  72. ncbi Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
    Paolo Gionchetti
    Department of Internal Medicine, University of Bologna, Italy
    Gastroenterology 124:1202-9. 2003
    ..The aim of this study was to compare probiotic therapy with VSL#3 versus placebo in the ability to prevent the onset of acute pouchitis during the first year after ileal pouch-anal anastomosis...
  73. ncbi Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Germany
    Otolaryngol Head Neck Surg 132:566-9. 2005
    ..Recent studies demonstrated focal brain activation in the auditory cortex of patients with chronic tinnitus. Low-frequency repetitive transcranial magnetic stimulation (rTMS) is able to reduce cortical hyperexcitability...
  74. ncbi Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Lancet 371:205-14. 2008
    ..We aimed to assess the efficacy and safety of a new modified-release prednisone tablet compared with immediate-release prednisone in patients with this disease...
  75. pmc Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Ave E, Boston, Massachusetts 02215 1204, USA
    JAMA 299:2027-36. 2008
    ..Observational data suggest benefits may be greater among women, yet women have been underrepresented in published randomized trials...
  76. ncbi Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    B G Brown
    Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
    N Engl J Med 345:1583-92. 2001
    ..CONCLUSIONS: Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels. The use of antioxidant vitamins in this setting must be questioned...
  77. ncbi Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients
    T Heise
    Profil Institut für Stoffwechselforschung GmbH, Hellersbergstrasse, Neuss, Germany
    Diabetes Obes Metab 11:786-94. 2009
    ..To investigate the safety, tolerability, pharmacokinetic and pharmacodynamic properties of multiple oral doses of the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin (BI 1356) in patients with type 2 diabetes mellitus...
  78. ncbi The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress
    C R Markus
    TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Am J Clin Nutr 71:1536-44. 2000
    ..Therefore, a diet-induced increase in tryptophan availability may increase brain serotonin synthesis and improve coping and mood, particularly in stress-vulnerable subjects...
  79. pmc A randomized, blinded, controlled trial investigating the gastrointestinal health effects of drinking water quality
    M E Hellard
    Department of Epidemiology and Preventive Medicine, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia
    Environ Health Perspect 109:773-8. 2001
    ..We found no evidence of waterborne disease in Melbourne. The application of this methodology to other water supplies will provide a better understanding of the relationship between human health and water quality...
  80. ncbi Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 158:1557-65. 1998
    ..35, p < 0.001). We concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD...
  81. ncbi The landscape and lexicon of blinding in randomized trials
    Kenneth F Schulz
    Family Health International, Box 13950, Research Triangle Park, NC 27709, USA
    Ann Intern Med 136:254-9. 2002
  82. ncbi Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    B Komoroski
    Discovery Medicine and Clinical Pharmacology, Research and Development, Bristol Myers Squibb, Princeton, New Jersey, USA
    Clin Pharmacol Ther 85:520-6. 2009
    ....
  83. ncbi Cortisol variation in humans affects memory for emotionally laden and neutral information
    Heather C Abercrombie
    Department of Psychology, University of Wisconsin Madison, 1202 West Johnson Street, Madison, Wisconsin 53706, USA
    Behav Neurosci 117:505-16. 2003
    ..Results suggest that the effects of cortisol on memory do not differ substantially for emotional and neutral information. The study provides evidence of beneficial effects of acute cortisol elevations on explicit memory in humans...
  84. pmc Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
    M R Law
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1427. 2003
    ....
  85. ncbi Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects
    M Sneve
    Department of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
    Eur J Endocrinol 159:675-84. 2008
    ..Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults...
  86. ncbi Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis
    Paul Emery
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, United Kingdom
    J Rheumatol 36:1429-41. 2009
    ..To determine the relationship between radiographic progression and clinical response for adalimumab plus methotrexate (MTX) versus either monotherapy in patients with early rheumatoid arthritis (RA) in the PREMIER study...
  87. ncbi Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study
    Joel R Saper
    Michigan Head Pain and Neurological Institute, Ann Arbor 48104, USA
    Headache 42:470-82. 2002
    ..To assess the efficacy of tizanidine hydrochloride versus placebo as adjunctive prophylactic therapy for chronic daily headache (chronic migraine, migrainous headache, or tension-type headache)...
  88. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  89. ncbi n-3 fatty acids and cardiovascular events after myocardial infarction
    Daan Kromhout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    N Engl J Med 363:2015-26. 2010
    ....
  90. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  91. ncbi A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorder
    Laurence L Greenhill
    New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 109:E39. 2002
    ..To compare the efficacy, safety, and tolerability of once-daily administration of modified-release methylphenidate (MPH MR) with placebo in children with attention-deficit/hyperactivity disorder (ADHD)...
  92. ncbi Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
    ..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study...
  93. pmc A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults
    Issaka Sagara
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, BP 1805, Bamako, University of Bamako, Mali
    Vaccine 27:7292-8. 2009
    ..05). This is the first use of the novel adjuvant CPG 7909 in a malaria-exposed population...
  94. ncbi Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
    S N Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    JAMA 277:1380-6. 1997
    ..To determine whether long-term supplementation with vitamin E enhances in vivo, clinically relevant measures of cell-mediated immunity in healthy elderly subjects...
  95. ncbi Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively
    Nicola M Neary
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Endocrinology 146:5120-7. 2005
    ..Thus, PYY(3-36) and GLP-1(7-36), cosecreted after a meal, may inhibit food intake additively...
  96. ncbi Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:251-6. 2004
    ..It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency...
  97. ncbi Prucalopride, a systemic enterokinetic, for the treatment of constipation
    A V Emmanuel
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1347-56. 2002
    ..Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis...
  98. ncbi The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial
    D Carroll
    School of Sport and Exercise Sciences, University of Birmingham, UK
    Psychopharmacology (Berl) 150:220-5. 2000
    ..Vitamin and mineral supplements may be associated with improved psychological status...
  99. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    ..To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS)...
  100. pmc Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    M Marre
    Service d Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, Paris, France
    Diabet Med 26:268-78. 2009
    ..To compare the effects of combining liraglutide (0.6, 1.2 or 1.8 mg/day) or rosiglitazone 4 mg/day (all n >or= 228) or placebo (n = 114) with glimepiride (2-4 mg/day) on glycaemic control, body weight and safety in Type 2 diabetes...
  101. ncbi Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial
    Shawn D Aaron
    The Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 146:545-55. 2007
    ..Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied...

Research Grants62

  1. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..Brains will be stained with H+E and immunostained for tyrosine hydroxylase and B and T cell markers. Stereologically corrected counts of TH-positive neurons will be determined. ..
  2. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..
  3. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    ..To study this we designed a randomized, placebo-controlled, double- blind study with several different doses of ketamine. ..
  4. Pilot Combination Treatment Trial of Mild Cognitive Impairment with Depression
    Davangere P Devanand; Fiscal Year: 2013
    ..The study will also provide important information on neurobiological moderators of treatment response and course in DEP-CI. ..
  5. Studies on Serial Phlebotomy in Voluntary Blood Donors
    Stuart D Katz; Fiscal Year: 2013
    ....
  6. Lactoferrin for prevention of sepsis in infants
    Theresa J Ochoa; Fiscal Year: 2013
    ..If successful, this study could profoundly affect clinical care of neonates both in the developed and developing world. ..
  7. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh B Singhal; Fiscal Year: 2010
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  8. Endotoxin-induced inflammation affects striatal dopamine: A raclopride PET study
    Evan D Morris; Fiscal Year: 2013
    ..A better understanding of these pathways can lead to the development of new treatments for this common and disabling symptom;such treatments could ultimately improve the wellbeing of millions of patients. ..
  9. Genetics and Personalized Medicine: From Population Studies to Clinical Therapy
    Christie M Ballantyne; Fiscal Year: 2010
    ....
  10. Aldosterone and Diabetic Cardiovascular Disease: Research and Mentoring Progam
    GAIL KURR ADLER; Fiscal Year: 2013
    ....
  11. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    Gregg H Gilbert; Fiscal Year: 2010
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  12. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel A Shugars; Fiscal Year: 2010
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  13. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Tochukwu Amaechi; Fiscal Year: 2010
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  14. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James D Bader; Fiscal Year: 2010
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  15. Role of P2Y Receptors and Activated Platelets in Inflammation
    ANALIA E GARCIA; Fiscal Year: 2012
    ..Further, they will also help us understand the role of P2Y12 receptors in inflammation and contribute to better treatments and to design therapeutics for inflammatory diseases. ..
  16. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    WILLIAM MARION VOLLMER; Fiscal Year: 2011
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  17. Optimizing Recovery and Preservation of Endogenous Insulin Secretion
    STEVEN EMANUEL KAHN; Fiscal Year: 2013
    ..Further, they will inform regarding the utility of simpler measures for assessing glucose metabolism in large scale clinical trials. ..
  18. BRIDGE TRIAL
    Thomas L Ortel; Fiscal Year: 2013
    ..This prospective, randomized, double-blind study will definitively answer this question for patients with atrial fibrillation who are on warfarin therapy. ..
  19. BRIDGE TRIAL
    Victor Hasselblad; Fiscal Year: 2013
    ..This prospective, randomized, double-blind study will definitively answer this question for patients with atrial fibrillation who are on warfarin therapy. ..
  20. Endothelial Function in Human Peripheral Arteries
    Vikram S Kashyap; Fiscal Year: 2010
    ..We will test a novel clot-dissolving combination that may improve cellular function and outcomes after artery clotting. ..
  21. Mammographic Density and Soy Isoflavones
    Lee Jane W Lu; Fiscal Year: 2010
    ..The study may lead to a novel, non-invasive and economical approach to breast cancer prevention. ..
  22. A Study of ILV-94 (Anti-22 Antibody) Administered via IV in Atopic Dermatitis
    Emma Guttman; Fiscal Year: 2013
    ..IL-22 is a potential key cytokine in AD and inhibiting it may provide significant advantages over other available treatments, including: a selective target and potential safety advantages compared to broad immune suppressants. ..
  23. Neuroimaging of diet and medication in the treatment of ADHD
    Steven R Pliszka; Fiscal Year: 2013
    ..We seek to determine if the diet impacts functional connectivity (via DCM as above) in both the attention and reward networks and if such changes predict behavioral outcome. ..
  24. Fibromyalgia and Sleep Treatments
    Nancy A Hamilton; Fiscal Year: 2010
    ..The long-term objective of this study is to develop an empirically supported, effective treatment for FM, thus reducing the high health care costs incurred by FM patients and minimizing patient suffering. ..
  25. Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
    Franklin R Schneier; Fiscal Year: 2012
    ..This study examines a strategy for augmenting the effect of treatment with the SSRI sertraline, by combining it with another antidepressant mirtazapine, or placebo, over 24 weeks of treatment. ..
  26. PREVENTION OF ULCER HEMORRHAGE BY H PYLORI ERADICATION
    Dennis Jensen; Fiscal Year: 2000
    ....
  27. Post-Stroke Aphasia and rTMS Treatment (PART) Study
    Jerzy P Szaflarski; Fiscal Year: 2013
    ..This aim will gather preliminary data regarding the possible synergistic effects of nerTMS and behavioral intervention. ..
  28. Prevention of Vitamin D Deficiency in Breastfed Infants
    Ekhard Ziegler; Fiscal Year: 2009
    ..The study has considerable public health importance because of the importance of preventing vitamin D deficiency not only in its severe form, rickets, but also in its milder forms. ..
  29. Combining Antidepressants to Hasten Remission from Depression
    Jonathan W Stewart; Fiscal Year: 2010
    ....
  30. Combining Antidepressants to Hasten Remission from Depression
    Pierre Blier; Fiscal Year: 2010
    ....
  31. Colon Cancer Prevention Program Project Grant
    M Lance; Fiscal Year: 2009
    ..abstract_text> ..
  32. ORAL L GLUTAMINE THERAPY FOR SICKLE CELL ANEMIA
    Yutaka Niihara; Fiscal Year: 2001
    ..The pilot data are promising. This project will provide the pathophysiologic basis for the use of L-glutamine and will evaluate the efficacy of L-glutamine in the therapy of sickle cell anemia. ..
  33. DOUBLE-BLIND STUDY FOR LONG-TERM OF ULCER HEMORRHAGE
    Dennis Jensen; Fiscal Year: 1992
    ..Pylori eradication for patients with an ulcer hemorrhage will be defined, and 3) these outcomes will have profound implications for the management of a large group of patients worldwide with peptic ulcer disease...
  34. DOUBLE-BLIND BOTULINUM TOXIN FOR SPASMODIC DYSPHONIA
    Mitchell Brin; Fiscal Year: 1991
    ....
  35. Targeted Pharmacologic Interventions for Autism
    Christopher J McDougle; Fiscal Year: 2011
    ..This research is also unique in its plan to identify genetic predictors of response to drug treatment in autism. ..
  36. CHEMOPREVENTION IN HUMAN BRONCHIAL METAPLASIA/DYSPLASIA
    WAUN HONG; Fiscal Year: 1991
    ..This study will provide the information necessary to develop a rational approach for premalignant squamous metaplasia/dysplasia and to direct the future development of chemoprevention in lung cancer...
  37. Continuation of NET-PD Trials at The Parkinson's Institute
    Caroline M Tanner; Fiscal Year: 2013
    ..As the burden of disease increases worldwide, this becomes a critical public health concern. ..
  38. Engineered Spores as Fluorogenic Biological Indicators for Sterility Testing
    Boris Rotman; Fiscal Year: 2009
    ..To provide more rapid sterility assurance, BCR Diagnostics has engineered unique living microorganisms that promptly (less than 30 min) send fluorescent light signals when the sterilization process is inadequate. ..
  39. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..The relative predictive ability of the markers will be assessed using multiple logistic regression along with other potential predictive variables including the expression of RAR and/or RXR. ..
  40. PHARMACOTHERAPY OF CUE INDUCED COCAINE CRAVING
    S Berger; Fiscal Year: 2000
    ..This will provide the basis for a more definitive clinical trial of the relationship between cue-induced cocaine craving and relapse. ..
  41. Innovative intervention for healing of diabetic ulcers
    Joyce Stechmiller; Fiscal Year: 2005
    ..Data will be analyzed using multivariate methods. Translating advances in the bio molecular and genetic basis of diabetes and diabetic wound healing is needed to improve nursing care and quality of life. ..
  42. FOLIC ACID INTAKE & HOMOCYSTEINE--A DOSE RESPONSE STUDY
    Shirley Beresford; Fiscal Year: 2000
    ..Estimates of potential cardiovascular benefit will be calculated by integrating the results of this proposed study with a meta-analysis of studies of the relationship between homocysteine and risk of cardiovascular disease. ..
  43. Aerosolized hyaluronic acid as a treatment for COPD
    Gerard Turino; Fiscal Year: 2006
    ..Aerosolized HA has the potential to become the first effective therapeutic product that alters the degenerative course of emphysema by preserving-and possibly even restoring-lung function. [unreadable] [unreadable] [unreadable]..
  44. Hormone Replacement and Cerebral Glucose Metabolism
    John Woodard; Fiscal Year: 2000
    ....
  45. Planning Grant for Reduction of Uric Acid to Prevent Hypertension (RAPHY) Trial
    Daniel Feig; Fiscal Year: 2009
    ..This trial may provide a new paradigm for preventive therapy of hypertension, a disease that effecting more than 30% of Americans and causes nearly 1 million deaths a year in the USA. ..
  46. SERTRALINE AND COGNITIVE THERAPY IN DEPRESSED ALCOHOLICS
    Darlene Moak; Fiscal Year: 1999
    ....
  47. CARBAMAZEPINE IN THE TREATMENT OF COCAINE ABUSE
    JAMES HALIKAS; Fiscal Year: 1993
    ..The research will provide information as to the effectiveness and feasibility of carbamazepine as an adjunct to traditional treatment activities...
  48. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..Quantifying two types of postural and oromotor control in the same subjects will also substantially increase our understanding of the role of the basal ganglia in axial motor control. ..
  49. ULTRAVIOLET LIGHTS IN HVAC SYSTEMS--EFFECT ON HEALTH AND
    Dick Menzies; Fiscal Year: 2000
    ..Airborne endotoxin concentrations would be reduced, and therefore the resultant health effects reduced, if GUV was successful in eradicating microbial contamination of central HVAC systems. ..
  50. BIOSENSORS OF COCAINE AND HEROIN ABUSE
    MOHYEE ELDEFRAWI; Fiscal Year: 1999
    ..Recombinant gene cloning technology provides a large variety of mAbs from which to select rapidly the most sensitive and specific ones against BE and M3G. ..
  51. SELECT Pre-Clinical Trial of Prostate Cancer
    Nihal Ahmad; Fiscal Year: 2010
    ..abstract_text> ..
  52. FUNCTIONAL TEST OF ZN NUTRITURE BY ZN STIMULATION OF ACE
    Tsunenobu Tamura; Fiscal Year: 1993
    ..Access to this population will provide us with an excellent opportunity to evaluate the proposed ACE in vitro stimulation of activity by zinc as a method for assessing zinc nutriture in humans...
  53. FLUOXETINE FOR ANXIOUS CHILDREN
    Boris Birmaher; Fiscal Year: 2000
    ....
  54. Acceptability of pharmacologic treatment for methamphetamine dependence among MSM
    Grant Colfax; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  55. Naltrexone Treatment in Pathologic Gambling Disorder
    SUCK KIM; Fiscal Year: 2004
    ..S. The implications of our study expand from PGD to other impulse control disorders, including compulsive shopping, kleptomania and possible alcoholism. ..
  56. PROTEIN SUPPLEMENTATION OF FORMULA FOR PRETERM INFANTS
    Ekhard Ziegler; Fiscal Year: 1999
    ..Intakes of calories and of protein will be determined daily. The primary outcome will be growth, with measures of protein nutritional status and of erythropoietic activity as secondary outcomes. ..
  57. MENTORED MEDICAL STUDENT CLINICAL RESEARCH PROGRAM
    David Herndon; Fiscal Year: 2000
    ..abstract_text> ..
  58. EPR STUDIES ON DETECTION AND TREATMENT OF CANCER
    JOHN ZIMBRICK; Fiscal Year: 1980
    ..Studies on the molecular properties of CP, including single crystals of CP, will be continued. These will include electron spin echo studies which may help to characterize the binding sites of Cu in the molecule...
  59. MELATONIN FOR SLEEP DISORDERS IN PARKINSONS DISEASE
    Glenna Dowling; Fiscal Year: 2000
    ..Similar analyses and descriptive statistics will be used to analyze data for the secondary aims. This research will lead to the development of safer, more physiologic therapies for treating sleep disturbances in patients with PD. ..
  60. QUALITY OF LIFE--PARKINSON PATIENTS WITH NEURAL IMPLANTS
    Cynthia McRae; Fiscal Year: 1999
    ..Second, the study will determine the extent to which perception of the type of treatment received is linked to quality of life. ..
  61. The Biology of Resilience: Oxytocin, Social Relationships and Health
    Laura D Kubzansky; Fiscal Year: 2010
    ..Ultimately, a neurobiological understanding of resilience may inform efforts for both prevention and intervention of diseases or problems common in later life. ..
  62. Ethanol Interactions of the Melatonin Agonist PD6735
    Frank Zemlan; Fiscal Year: 2007
    ..The proposed study will evaluate the safety of PD6735 in combination with EtOH. [unreadable] [unreadable] [unreadable]..