double blind method

Summary

Summary: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

Top Publications

  1. ncbi Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    Stanley B Cohen
    Radiant Research, Dallas, Texas 75235, USA
    Arthritis Rheum 54:2793-806. 2006
  2. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
  3. doi Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
    Thomas Baumgartner
    Center for the Study of Social and Neural Systems, Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Neuron 58:639-50. 2008
  4. pmc Effectiveness of cellulose sulfate vaginal gel for the prevention of HIV infection: results of a Phase III trial in Nigeria
    Vera Halpern
    Family Health International, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 3:e3784. 2008
  5. doi Efficacy and safety of atomoxetine as add-on to psychoeducation in the treatment of attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in stimulant-naïve Swedish children and adolescents
    Pär Svanborg
    Eli Lilly Sweden AB, Gustav III Boulevard 42, Box 721, 169 27, Solna, Sweden
    Eur Child Adolesc Psychiatry 18:240-9. 2009
  6. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
  7. ncbi Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Lancet 352:609-13. 1998
  8. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
  9. ncbi Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
    JAMA 292:1307-16. 2004
  10. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003

Detail Information

Publications240 found, 100 shown here

  1. ncbi Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    Stanley B Cohen
    Radiant Research, Dallas, Texas 75235, USA
    Arthritis Rheum 54:2793-806. 2006
    ....
  2. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
    ..The neuropeptide oxytocin plays a central role in social approach behavior in nonhuman mammals...
  3. doi Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
    Thomas Baumgartner
    Center for the Study of Social and Neural Systems, Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Neuron 58:639-50. 2008
    ..These findings may help to develop deeper insights into mental disorders such as social phobia and autism, which are characterized by persistent fear or avoidance of social interactions...
  4. pmc Effectiveness of cellulose sulfate vaginal gel for the prevention of HIV infection: results of a Phase III trial in Nigeria
    Vera Halpern
    Family Health International, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 3:e3784. 2008
    ..This trial evaluated the safety and effectiveness of 6% cellulose sulfate vaginal gel in preventing male-to-female vaginal transmission of HIV, gonorrhea and chlamydial infection...
  5. doi Efficacy and safety of atomoxetine as add-on to psychoeducation in the treatment of attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in stimulant-naïve Swedish children and adolescents
    Pär Svanborg
    Eli Lilly Sweden AB, Gustav III Boulevard 42, Box 721, 169 27, Solna, Sweden
    Eur Child Adolesc Psychiatry 18:240-9. 2009
    ..HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safety of the treatment are described...
  6. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    ..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
  7. ncbi Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Lancet 352:609-13. 1998
    ..We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs)...
  8. ncbi Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    S Yusuf
    Canadian Cardiovascular Collaboration Project Office, Hamilton General Hospital, McMaster University, ON
    N Engl J Med 342:145-53. 2000
    ..We assessed the role of an angiotensin-converting-enzyme inhibitor, ramipril, in patients who were at high risk for cardiovascular events but who did not have left ventricular dysfunction or heart failure...
  9. ncbi Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
    JAMA 292:1307-16. 2004
    ..Limited data are available evaluating how the timing and intensity of statin therapy following an acute coronary syndrome (ACS) event affect clinical outcome...
  10. ncbi Inhibition of food intake in obese subjects by peptide YY3-36
    Rachel L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Rd, London W12 0NN, United Kingdom
    N Engl J Med 349:941-8. 2003
    ..However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY...
  11. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  12. doi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  13. pmc Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    W Kruis
    Evangelisches Krankenhaus Kalk, University of Cologne, Germany
    Gut 53:1617-23. 2004
    ..We compared the efficacy in maintaining remission of the probiotic preparation Escherichia coli Nissle 1917 and established therapy with mesalazine in patients with ulcerative colitis...
  14. pmc Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
    Michele D Spring
    United States Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 4:e5254. 2009
    ....
  15. ncbi Acute administration of d-amphetamine decreases impulsivity in healthy volunteers
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 27:813-25. 2002
    ..These results suggest that acute doses of amphetamine decrease several forms of impulsive behavior. These findings extend and confirm previous findings in humans and laboratory animals...
  16. ncbi The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 345:870-8. 2001
    ..02). CONCLUSIONS: Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria...
  17. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
    ..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
  18. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  19. pmc Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    Philip Bejon
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    N Engl J Med 359:2521-32. 2008
    ..We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children 5 to 17 months of age, a target population for vaccine licensure...
  20. pmc A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali
    Issaka Sagara
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry BP 1805 Bamako, University of Bamako, Mali, Malaysia
    Vaccine 27:3090-8. 2009
    ..5 g/dL, in the direction of lower hemoglobin in the children who received AMA1-C1, although these differences were not significant after correction for multiple tests. These differences were not seen in the second year of transmission...
  21. ncbi A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Ganesh Raghu
    Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
    N Engl J Med 350:125-33. 2004
    ..Idiopathic pulmonary fibrosis is a progressive, fatal disease with no known efficacious therapy...
  22. ncbi Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study
    Nunziata Morabito
    Department of Internal Medicine, University of Messina, Italy
    J Bone Miner Res 17:1904-12. 2002
    ....
  23. ncbi Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases
    Suzanne M Garland
    Microbiology and Infectious Diseases Department, Royal Women s Hospital, and the University of Melbourne, Melbourne, Australia
    N Engl J Med 356:1928-43. 2007
    ..A phase 3 trial was conducted to evaluate the efficacy of a prophylactic quadrivalent vaccine in preventing anogenital diseases associated with human papillomavirus (HPV) types 6, 11, 16, and 18...
  24. ncbi Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
    M Kalliomaki
    Department of Paediatrics, University of Turku and Turku University Hospital, Finland
    Lancet 357:1076-9. 2001
    ..We assessed the effect on atopic disease of Lactobacillus GG (which is safe at an early age and effective in treatment of allergic inflammation and food allergy)...
  25. ncbi Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  26. ncbi Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..Resultant increases in inspiratory capacity permitted greater expansion of tidal volume and contributed to improvements in both exertional dyspnoea and exercise endurance...
  27. ncbi Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    S Hulley
    University of California, San Francisco 94143, USA
    JAMA 280:605-13. 1998
    ..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue...
  28. ncbi Sertraline treatment of major depression in patients with acute MI or unstable angina
    Alexander H Glassman
    Department of Clinical Psychopharmacology, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 116, New York, NY 10032, USA
    JAMA 288:701-9. 2002
    ..However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease...
  29. ncbi Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial
    Norihiro Nishimoto
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, Suita City, Osaka, Japan
    Arthritis Rheum 50:1761-9. 2004
    ..This study was undertaken to evaluate the safety and efficacy of a humanized anti-IL-6 receptor antibody, MRA, in patients with RA...
  30. doi Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection
    Kent E Kester
    Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    J Infect Dis 200:337-46. 2009
    ..To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals)...
  31. ncbi Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 19:633-9. 2005
    ..Methylphenidate did not affect memory or mood at any time of testing. A single dose of MDMA produces transient memory impairment...
  32. ncbi Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    Peter Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 361:449-56. 2003
    ..We postulated that a combination of these treatments would be better than each component used alone...
  33. doi Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects
    M Sneve
    Department of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
    Eur J Endocrinol 159:675-84. 2008
    ..Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults...
  34. pmc Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
    M R Law
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ
    BMJ 326:1427. 2003
    ....
  35. ncbi The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
    Ferdinand C Breedveld
    Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, C4 R Postbox 9600, Leiden 2300 RC, The Netherlands
    Arthritis Rheum 54:26-37. 2006
    ..To compare the efficacy and safety of adalimumab plus methotrexate (MTX) versus MTX monotherapy or adalimumab monotherapy in patients with early, aggressive rheumatoid arthritis (RA) who had not previously received MTX treatment...
  36. doi Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    B Komoroski
    Discovery Medicine and Clinical Pharmacology, Research and Development, Bristol Myers Squibb, Princeton, New Jersey, USA
    Clin Pharmacol Ther 85:520-6. 2009
    ....
  37. ncbi Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study
    Joel R Saper
    Michigan Head Pain and Neurological Institute, Ann Arbor 48104, USA
    Headache 42:470-82. 2002
    ..To assess the efficacy of tizanidine hydrochloride versus placebo as adjunctive prophylactic therapy for chronic daily headache (chronic migraine, migrainous headache, or tension-type headache)...
  38. ncbi Cortisol variation in humans affects memory for emotionally laden and neutral information
    Heather C Abercrombie
    Department of Psychology, University of Wisconsin Madison, 1202 West Johnson Street, Madison, Wisconsin 53706, USA
    Behav Neurosci 117:505-16. 2003
    ..Results suggest that the effects of cortisol on memory do not differ substantially for emotional and neutral information. The study provides evidence of beneficial effects of acute cortisol elevations on explicit memory in humans...
  39. doi Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis
    Paul Emery
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, United Kingdom
    J Rheumatol 36:1429-41. 2009
    ..To determine the relationship between radiographic progression and clinical response for adalimumab plus methotrexate (MTX) versus either monotherapy in patients with early rheumatoid arthritis (RA) in the PREMIER study...
  40. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  41. ncbi A double-blind, placebo-controlled study of modified-release methylphenidate in children with attention-deficit/hyperactivity disorder
    Laurence L Greenhill
    New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 109:E39. 2002
    ..To compare the efficacy, safety, and tolerability of once-daily administration of modified-release methylphenidate (MPH MR) with placebo in children with attention-deficit/hyperactivity disorder (ADHD)...
  42. ncbi Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
    Bjorn Dahlof
    Sahlgrenska University Hospital Ostra, Gothenburg, Swede
    Lancet 359:995-1003. 2002
    ..We aimed to establish whether selective blocking of angiotensin II improves LVH beyond reducing blood pressure and, consequently, reduces cardiovascular morbidity and death...
  43. ncbi Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    Lars Klareskog
    Rheumatology Unit, Department of Medicine, Karolinska Institute Karolinska Hospital, Stockholm 17176, Sweden
    Lancet 363:675-81. 2004
    ..We aimed to assess combination treatment with etanercept and methotrexate versus the monotherapies in patients with rheumatoid arthritis...
  44. ncbi Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
    ..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study...
  45. doi Recombinant human erythropoietin in the treatment of acute ischemic stroke
    Hannelore Ehrenreich
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Stroke 40:e647-56. 2009
    ..Accordingly, the double-blind, placebo-controlled, randomized German Multicenter EPO Stroke Trial (Phase II/III; ClinicalTrials.gov Identifier: NCT00604630) was designed to evaluate efficacy and safety of EPO in stroke...
  46. doi n-3 fatty acids and cardiovascular events after myocardial infarction
    Daan Kromhout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    N Engl J Med 363:2015-26. 2010
    ....
  47. ncbi Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial
    Shawn D Aaron
    The Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 146:545-55. 2007
    ..Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied...
  48. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    ..To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS)...
  49. ncbi Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial
    Kenneth C Kalunian
    University of California, Los Angeles School of Medicine, USA
    Arthritis Rheum 46:3251-8. 2002
    ..To evaluate the safety and efficacy of a humanized monoclonal antibody against CD154 (IDEC-131) in patients with active systemic lupus erythematosus (SLE)...
  50. ncbi Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively
    Nicola M Neary
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Endocrinology 146:5120-7. 2005
    ..Thus, PYY(3-36) and GLP-1(7-36), cosecreted after a meal, may inhibit food intake additively...
  51. ncbi Prucalopride, a systemic enterokinetic, for the treatment of constipation
    A V Emmanuel
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1347-56. 2002
    ..Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis...
  52. pmc Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial
    F Verdon
    General Practice Unit, University of Lausanne, Rue du Bugnon 44, 1011 Lausanne, Switzerland
    BMJ 326:1124. 2003
    ..To determine the subjective response to iron therapy in non-anaemic women with unexplained fatigue...
  53. ncbi Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
    S N Meydani
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    JAMA 277:1380-6. 1997
    ..To determine whether long-term supplementation with vitamin E enhances in vivo, clinically relevant measures of cell-mediated immunity in healthy elderly subjects...
  54. ncbi Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    J Psychopharmacol 18:251-6. 2004
    ..It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency...
  55. ncbi The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial
    D Carroll
    School of Sport and Exercise Sciences, University of Birmingham, UK
    Psychopharmacology (Berl) 150:220-5. 2000
    ..Vitamin and mineral supplements may be associated with improved psychological status...
  56. pmc Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    M Marre
    Service d Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat Claude Bernard, Paris, France
    Diabet Med 26:268-78. 2009
    ..To compare the effects of combining liraglutide (0.6, 1.2 or 1.8 mg/day) or rosiglitazone 4 mg/day (all n >or= 228) or placebo (n = 114) with glimepiride (2-4 mg/day) on glycaemic control, body weight and safety in Type 2 diabetes...
  57. pmc Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety
    C T Bolliger
    Respiratory Division, Department of Internal Medicine, University Hospital, 4031 Basle, Switzerland
    BMJ 321:329-33. 2000
    ..To determine whether use of an oral nicotine inhaler can result in long term reduction in smoking and whether concomitant use of nicotine replacement and smoking is safe...
  58. pmc IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
    P Emery
    Leeds Teaching Hospitals Trust, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:1516-23. 2008
    ..The phase III RADIATE study examined the efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody in patients with rheumatoid arthritis (RA) refractory to tumour necrosis factor (TNF) antagonist therapy...
  59. ncbi Efficacy and safety of a new Botulinum Toxin Type A free of complexing proteins in the treatment of blepharospasm
    P Roggenkämper
    Department of Ophthalmology, University of Bonn, Wiesbaden, Germany
    J Neural Transm 113:303-12. 2006
    ..These data show that NT 201* is an effective and safe treatment for patients suffering from blepharospasm...
  60. ncbi Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants
    Jan Knol
    Numico Research B V, Wageningen, The Netherlands
    J Pediatr Gastroenterol Nutr 40:36-42. 2005
    ....
  61. ncbi Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine
    E A Balbisi
    St John s University, College of Pharmacy and Allied Health Professions, and Ambulatory Medicine, Queens Hospital Center, Jamaica, New York 11439, USA
    Int J Clin Pract 58:695-705. 2004
    ..Given the fact that patient response to serotonin agonists is individualised, and selecting an effective agent may involve trial and error, frovatriptan is a welcome alternative in the acute management of migraine...
  62. pmc Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans
    Ian D Davis
    Ludwig Institute for Cancer Research, Melbourne 3084, Australia
    Proc Natl Acad Sci U S A 101:10697-702. 2004
    ..In an unplanned analysis, vaccinated patients appeared to have superior clinical outcomes to those treated with placebo or protein alone. The vaccine is safe and highly potent immunologically...
  63. ncbi BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
    Talmadge E King
    Department of Medicine, UCSF, 505 Parnassus Avenue, Room M994, San Francisco, CA 94110, USA
    Am J Respir Crit Care Med 177:75-81. 2008
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease lacking effective treatment...
  64. ncbi Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
    Christoph Wanner
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 353:238-48. 2005
    ..However, the benefit of statins in such patients receiving hemodialysis, who are at high risk for cardiovascular disease and death, has not been examined...
  65. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  66. doi Characteristics of migraine attacks and responses to almotriptan treatment: a comparison of menstrually related and nonmenstrually related migraines
    Merle L Diamond
    Diamond Headache Clinic, Chicago, IL 60614, USA
    Headache 48:248-58. 2008
    ..To compare the clinical characteristics of menstrually related migraines (MRMs) and nonmenstrually related migraines (nonMRMs) and to investigate the efficacy of almotriptan in the treatment of these migraine subtypes...
  67. pmc Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG
    C Prantera
    Division of Gastroenterology, Azienda Ospedaliera S Camillo Forlanini, Rome, Italy
    Gut 51:405-9. 2002
    ..The aim of this randomised placebo controlled study was to determine if Lactobacillus GG, given by mouth for one year, could prevent Crohn's recurrent lesions after surgery or to reduce their severity...
  68. ncbi Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Am J Respir Crit Care Med 166:1084-91. 2002
    ..We conclude that FSC improved lung function and reduced the severity of dyspnea compared with individual components and placebo...
  69. doi Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial
    Frank Buttgereit
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Lancet 371:205-14. 2008
    ..We aimed to assess the efficacy and safety of a new modified-release prednisone tablet compared with immediate-release prednisone in patients with this disease...
  70. ncbi Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions
    Wei Cheng You
    Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China
    J Natl Cancer Inst 98:974-83. 2006
    ..We conducted a randomized trial to test the effects of one-time H. pylori treatment and long-term vitamin or garlic supplements in reducing the prevalence of advanced precancerous gastric lesions...
  71. ncbi Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation
    Timothy Trebble
    The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 90:405-12. 2003
    ..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake...
  72. ncbi A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection
    Keith P Klugman
    Medical Research Council, University of the Witwatersrand, National Institute for Communicable Diseases, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
    N Engl J Med 349:1341-8. 2003
    ..We evaluated the efficacy of a 9-valent pneumococcal conjugate vaccine in a randomized, double-blind study in Soweto, South Africa...
  73. ncbi Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour
    R D Rogers
    Departments of Experimental Psychology and Psychiatry, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 146:482-91. 1999
    ..However, little research has addressed the specific cognitive consequences of changed monoaminergic function that might contribute to the production of impulsive behaviour...
  74. ncbi Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  75. ncbi Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist
    A N Vgontzas
    Department of Psychiatry H073, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:4409-13. 2004
    ..9 vs. 3.1 min), suggests that proinflammatory cytokines contribute to the pathogenesis of OSA/sleepiness...
  76. ncbi Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease
    R S Doody
    Department of Neurology, Baylor College of Medicine, 6550 Fannin Street, Suite 1801, Houston, TX 77030-3498, USA
    Arch Neurol 58:427-33. 2001
    ..CONCLUSIONS: Donepezil is an effective and safe drug for the long-term symptomatic treatment of mild to moderately severe AD for up to 144 weeks (2.8 years), and sustained treatment may confer some advantages...
  77. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
    ..CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes...
  78. ncbi The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD
    Nicola A Hanania
    Baylor College of Medicine, Pulmonary Critical Care, Ben Taub General Hospital, 1504 Taub Loop, Houston, TX 77030, USA
    Chest 124:834-43. 2003
    ....
  79. ncbi Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    S Gilman
    Department of Neurology, University of Michigan, 300 N Ingalls 3D15, Ann Arbor, MI 48109 0489, USA
    Neurology 64:1553-62. 2005
    ..The authors report the results of a phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of meningoencephalitis in 6% of immunized patients...
  80. ncbi A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    Paul M Ridker
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, USA
    N Engl J Med 352:1293-304. 2005
    ..Randomized trials have shown that low-dose aspirin decreases the risk of a first myocardial infarction in men, with little effect on the risk of ischemic stroke. There are few similar data in women...
  81. ncbi Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial
    M G Serpell
    University Department of Anaesthesia and Pain Management, Gartnavel General Hospital, 30 Shelly Court, G12 0YN, Scotland, Glasgow, UK
    Pain 99:557-66. 2002
    ..This study shows that gabapentin reduces pain and improves some quality-of-life measures in patients with a wide range of neuropathic pain syndromes...
  82. ncbi Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial
    Dennis E Niewoehner
    Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Ann Intern Med 143:317-26. 2005
    ..Patients with chronic obstructive pulmonary disease (COPD) frequently develop exacerbations, leading to major clinical and health resource use ramifications...
  83. ncbi Zinc and iron supplementation and malaria, diarrhea, and respiratory infections in children in the Peruvian Amazon
    Stephanie A Richard
    Center for Human Nutrition, and Department of International Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 75:126-32. 2006
    ..vivax malaria-endemic areas, although local endemicity and species-specific prevalence should be considered carefully when designing any supplementation program involving iron in a malaria-endemic area...
  84. ncbi PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial
    Marla J Keller
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 193:27-35. 2006
    ..This study was designed to determine the antiviral activity in cervicovaginal lavage (CVL) samples collected after intravaginal application of 0.5% PRO 2000 gel (Indevus)...
  85. ncbi Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 160:542-9. 1999
    ..IC should be used in conjunction with FEV(1) when evaluating therapeutic responses in COPD...
  86. pmc A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults
    Issaka Sagara
    Malaria Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, BP 1805, Bamako, University of Bamako, Mali
    Vaccine 27:7292-8. 2009
    ..05). This is the first use of the novel adjuvant CPG 7909 in a malaria-exposed population...
  87. ncbi Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected
    Ofer Agid
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Arch Gen Psychiatry 60:1228-35. 2003
    ..To understand the mechanism of action of antipsychotic drugs, it is critical to recognize the time course over which these medications take effect. Current models of antipsychotic action presume a "delayed onset" of action...
  88. pmc Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial
    W J Sandborn
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gut 56:1232-9. 2007
    ..Adalimumab induced clinical remission after four weeks in patients with active Crohn's disease in the CLASSIC I trial...
  89. ncbi Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 9:1075-82. 2004
    ..These findings also suggest that variations in the CRHR1 gene may affect response to CRHR1 agonists or antagonists. All data are deposited in www.pharmgkb.org...
  90. doi Diclofenac sodium gel in patients with primary hand osteoarthritis: a randomized, double-blind, placebo-controlled trial
    Roy D Altman
    Department of Rheumatology and Immunology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    J Rheumatol 36:1991-9. 2009
    ..To measure the efficacy and safety of diclofenac sodium gel in patients with primary hand osteoarthritis (OA)...
  91. ncbi Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections
    Trish M Perl
    University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
    N Engl J Med 346:1871-7. 2002
    ..Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections...
  92. ncbi The efficacy and safety of combination salmeterol (50 microg)/fluticasone propionate (500 microg) inhalation twice daily via accuhaler in Chinese patients with COPD
    Jin ping Zheng
    Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, People s Republic of China
    Chest 132:1756-63. 2007
    ....
  93. ncbi Impact of preventing exacerbations on deterioration of health status in COPD
    S Spencer
    Dept of Health and Social Care, Brunel University, Isleworth, UK
    Eur Respir J 23:698-702. 2004
    ..Statistical modelling showed the beneficial effect of fluticasone propionate on deterioration in health status to be largely due to its effect on exacerbation frequency...
  94. ncbi Individual capacity differences predict working memory performance and prefrontal activity following dopamine receptor stimulation
    Sasha E B Gibbs
    University of California, Berkeley, California, USA
    Cogn Affect Behav Neurosci 5:212-21. 2005
    ..Individual differences in PFC dopamine receptor concentration may thus underlie the behavioral effects of dopamine stimulation on working memory function...
  95. doi Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway
    JAMA 300:795-804. 2008
    ..Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B(12) can lower plasma total homocysteine levels...
  96. pmc Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
    Lingxia Zeng
    Department of Public Health, Xi an Jiaotong University College of Medicine, PO Box 46, Xi an, Shaanxi 710061, China
    BMJ 337:a2001. 2008
    ..To examine the impact of antenatal supplementation with multiple micronutrients or iron and folic acid compared with folic acid alone on birth weight, duration of gestation, and maternal haemoglobin concentration in the third trimester...
  97. pmc Prevention of symptomatic seasonal influenza in 2005-2006 by inactivated and live attenuated vaccines
    Suzanne E Ohmit
    University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, Michigan 48109, USA
    J Infect Dis 198:312-7. 2008
    ....
  98. pmc Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty
    Per Essving
    Department of Orthopedic Surgery, University of Linkoping, Sweden
    Acta Orthop 80:213-9. 2009
    ..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...
  99. pmc Glucocorticoids reduce phobic fear in humans
    Leila M Soravia
    Institute of Psychology, Department of Clinical Psychology and Psychotherapy, University of Zurich, Zurichbergstrasse 43, CH 8044 Zurich, Switzerland
    Proc Natl Acad Sci U S A 103:5585-90. 2006
    ..Cortisol treatment did not reduce general, phobia-unrelated anxiety. In conclusion, the present findings in two distinct types of phobias indicate that glucocorticoid administration reduces phobic fear...
  100. pmc Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria
    F Ezzet
    Novartis Pharma AG, Basel, Switzerland
    Antimicrob Agents Chemother 44:697-704. 2000
    ..The high cure rates with the two six-dose regimens resulted from increased AUC and increased time at which lumefantrine concentrations were above the in vivo MIC...
  101. ncbi Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial
    C Gillberg
    Department of Child and Adolescent Psychiatry, University of Goteborg, Sweden
    Arch Gen Psychiatry 54:857-64. 1997
    ..We wanted to study the effects of amphetamine on symptoms of attention-deficit hyperactivity disorder (ADHD) over a longer period than has been reported in previous studies of central stimulants in this condition...

Research Grants74

  1. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..Brains will be stained with H+E and immunostained for tyrosine hydroxylase and B and T cell markers. Stereologically corrected counts of TH-positive neurons will be determined. ..
  2. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    William Vollmer; Fiscal Year: 2007
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  3. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    GREGG GILBERT; Fiscal Year: 2007
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  4. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..
  5. Prevention of Vitamin D Deficiency in Breastfed Infants
    Ekhard Ziegler; Fiscal Year: 2009
    ..The study has considerable public health importance because of the importance of preventing vitamin D deficiency not only in its severe form, rickets, but also in its milder forms. ..
  6. Prevention of Vitamin D Deficiency in Breastfed Infants
    Ekhard Ziegler; Fiscal Year: 2007
    ..The study has considerable public health importance because of the importance of preventing vitamin D deficiency not only in its severe form, rickets, but also in its milder forms. ..
  7. Temple University Gastroparesis Clinical Center
    Henry Parkman; Fiscal Year: 2007
    ..The protocols use novel diagnostic tests to better define the pathophysiology of gastroparesis. These studies will also better define the disease course of patients with gastroparesis. ..
  8. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel Shugars; Fiscal Year: 2007
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  9. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Amaechi; Fiscal Year: 2007
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  10. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James Bader; Fiscal Year: 2007
    ..Little research has been done on methods to prevent tooth decay in adults. This study would test how well a lozenge to be taken several times a day works to prevent tooth decay in adults who are prone to tooth decay. ..
  11. Studies on Serial Phlebotomy in Voluntary Blood Donors
    Stuart D Katz; Fiscal Year: 2010
    ....
  12. Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease
    GAIL ADLER; Fiscal Year: 2009
    ..If successful, this research will provide doctors with information about a new way to treat individuals with diabetes who have injuries to their blood vessels, heart and kidneys. ..
  13. Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease
    GAIL KURR ADLER; Fiscal Year: 2010
    ..If successful, this research will provide doctors with information about a new way to treat individuals with diabetes who have injuries to their blood vessels, heart and kidneys. ..
  14. Milwaukee Regional Clinical Center
    THOMAS AUFDERHEIDE; Fiscal Year: 2007
    ..Combining clinical and basic science, this translational research study will have significant impact by addressing this important national healthcare issue. ..
  15. Aerosolized hyaluronic acid as a treatment for COPD
    Gerard Turino; Fiscal Year: 2006
    ..Aerosolized HA has the potential to become the first effective therapeutic product that alters the degenerative course of emphysema by preserving-and possibly even restoring-lung function. ..