topical administration

Summary

Top Publications

  1. ncbi Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and in nitric oxide release by visible light irradiation
    Franciane Marquele-Oliveira
    Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Av do Cafe S N, Ribeirao Preto, SP, Brazil
    J Pharm Biomed Anal 53:843-51. 2010
  2. pmc Liquid versus gel handrub formulation: a prospective intervention study
    Ousmane Traore
    Infection Control Programme, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Crit Care 11:R52. 2007
  3. ncbi Effects of topical administration of 12-methyl tetradecanoic acid (12-MTA) on the development of corneal angiogenesis
    Nerida Cole
    Institute for Eye Research, Level 4, Rupert Myers Building, Gate 14, Barker Street, Kensington, Sydney, NSW 2052, Australia
    Angiogenesis 10:47-54. 2007
  4. ncbi Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    Timothy S Kern
    Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 56:373-9. 2007
  5. ncbi Dermatopharmacokinetic prediction of topical drug bioavailability in vivo
    Christophe Herkenne
    School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
    J Invest Dermatol 127:887-94. 2007
  6. pmc Topical ocular delivery of NSAIDs
    Munish Ahuja
    Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125 001, Haryana, India
    AAPS J 10:229-41. 2008
  7. ncbi Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial
    Peter S Tugwell
    Centre for Global Health, Institute of Population Health, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 31:2002-12. 2004
  8. ncbi Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial
    Sanford H Roth
    Arizona Research and Education, Phoenix, USA
    Arch Intern Med 164:2017-23. 2004
  9. ncbi Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs
    A A Acheampong
    Allergan, Irvine, CA 92715, USA
    Curr Eye Res 18:91-103. 1999
  10. ncbi Penetration profile of microspheres in follicular targeting of terminal hair follicles
    R Toll
    Department of Dermatology and Allergy, Centre of Experimental and Applied Cutaneous Physiology, Medical School of the Humboldt University of Berlin, Germany
    J Invest Dermatol 123:168-76. 2004

Detail Information

Publications229 found, 100 shown here

  1. ncbi Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and in nitric oxide release by visible light irradiation
    Franciane Marquele-Oliveira
    Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, Av do Cafe S N, Ribeirao Preto, SP, Brazil
    J Pharm Biomed Anal 53:843-51. 2010
    ..In this context, NRC-loaded lipid carriers were developed and characterized to further explore its topical administration for applications such as skin cancer treatment...
  2. pmc Liquid versus gel handrub formulation: a prospective intervention study
    Ousmane Traore
    Infection Control Programme, University of Geneva Hospitals, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Crit Care 11:R52. 2007
    ..Alcohol-based handrub is the new standard for hand hygiene action worldwide and usually requires a system change for its successful introduction in routine care. Product acceptability by HCWs is a crucial step in this process...
  3. ncbi Effects of topical administration of 12-methyl tetradecanoic acid (12-MTA) on the development of corneal angiogenesis
    Nerida Cole
    Institute for Eye Research, Level 4, Rupert Myers Building, Gate 14, Barker Street, Kensington, Sydney, NSW 2052, Australia
    Angiogenesis 10:47-54. 2007
    ..Our studies indicate that 12-MTA may provide clinically significant advantages over conventional steroids for the treatment of vessel growth in the cornea...
  4. ncbi Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    Timothy S Kern
    Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 56:373-9. 2007
    ..Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy...
  5. ncbi Dermatopharmacokinetic prediction of topical drug bioavailability in vivo
    Christophe Herkenne
    School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
    J Invest Dermatol 127:887-94. 2007
    ..Prediction and experiment agreed satisfactorily suggesting that objective and quantitative information, with which to characterize topical drug bioavailability, can be obtained from this approach...
  6. pmc Topical ocular delivery of NSAIDs
    Munish Ahuja
    Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125 001, Haryana, India
    AAPS J 10:229-41. 2008
    ..Recent studies showed that the use of colloidal nanoparticle formulations and the potent COX 2 inhibitor bromfenac may enhance NSAID efficacy in eye preparations...
  7. ncbi Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial
    Peter S Tugwell
    Centre for Global Health, Institute of Population Health, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 31:2002-12. 2004
    ..To compare the safety and efficacy of a topical diclofenac solution versus oral diclofenac in relieving the symptoms of primary osteoarthritis (OA) of the knee, in a randomized, double-blind, double-dummy equivalence trial...
  8. ncbi Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial
    Sanford H Roth
    Arizona Research and Education, Phoenix, USA
    Arch Intern Med 164:2017-23. 2004
    ..A new topical diclofenac sodium solution-containing the absorption enhancer dimethyl sulfoxide-was evaluated for the relief of the symptoms of primary OA of the knee...
  9. ncbi Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs
    A A Acheampong
    Allergan, Irvine, CA 92715, USA
    Curr Eye Res 18:91-103. 1999
    ..To determine the ocular pharmacokinetics of cyclosporin A after topical ophthalmic administration...
  10. ncbi Penetration profile of microspheres in follicular targeting of terminal hair follicles
    R Toll
    Department of Dermatology and Allergy, Centre of Experimental and Applied Cutaneous Physiology, Medical School of the Humboldt University of Berlin, Germany
    J Invest Dermatol 123:168-76. 2004
    ..Thus, the basis for follicular targeting of essential structures containing stem cells for keratinocytes, melanocytes, and mast cells has been laid...
  11. ncbi Sustained ocular delivery of tilisolol to rabbits after topical administration or intravitreal injection of lipophilic prodrug incorporated in liposomes
    S Kawakami
    School of Pharmaceutical Sciences, Nagasaki University, Japan
    J Pharm Pharmacol 53:1157-61. 2001
    ..O-Palmitoyl tilisolol was completely incorporated in the liposomes. After topical administration of O-palmitoyl tilisolol liposomes to the rabbit eye, O-palmitoyl tilisolol rapidly disappeared from the ..
  12. ncbi Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability
    Donatella Paolino
    Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria 6, I 95125 Catania, Italy
    Int J Pharm 244:21-31. 2002
    ..The human skin tolerability of various microemulsion formulations was evaluated on human volunteers. Microemulsions showed a good human skin tolerability...
  13. pmc Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial
    Arthur A M Bookman
    Dimethaid Health Care Ltd, 1405 Denison Street, Markham, Ontario L3R 5V2, Canada
    CMAJ 171:333-8. 2004
    ..The objective of this trial was to assess the safety and efficacy of a topical diclofenac solution in relieving the symptoms of primary osteoarthritis of the knee...
  14. ncbi Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical tr
    Wolfgang A Krueger
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen
    Am J Respir Crit Care Med 166:1029-37. 2002
    ..496-1.046). Surveillance cultures from tracheobronchial, oropharyngeal, and gastric secretions and from rectal swabs did not show any evidence for the selection of resistant microorganisms in the patients receiving prophylaxis...
  15. ncbi Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    R H Muller
    PharmaSol GmbH, Blohmstrasse 66a, 12307, Berlin, Germany
    Adv Drug Deliv Rev 54:S131-55. 2002
    ..Production issues also include clinical batch production, large scale production and regulatory aspects (e. g. status of excipients or proof of physical stability)...
  16. ncbi Fluconazole distribution in rat dermis following intravenous and topical application: a microdialysis study
    François Xavier Mathy
    Unite de Pharmacie Galenique, Universite Catholique de Louvain, Av E Mounier 73, UCL 73 20, 1200 Brussels, Belgium
    J Pharm Sci 94:770-80. 2005
    ..v.) and topical administration in the awake freely moving rat. Following i.v...
  17. ncbi Screening for new antioxidative compounds for topical administration using skin lipid model systems
    Hagen Trommer
    Institute of Pharmaceutics and Biopharmaceutics, School of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, D 06120 Halle Saale, Germany
    J Pharm Pharm Sci 8:494-506. 2005
    ..The effects of forty seven different substances (drugs, plant extracts, plant ingredients and polysaccharides) on UV irradiation induced lipid peroxidation were investigated...
  18. ncbi Topical administration of HSV gD-IL-2 DNA is highly protective against murine herpetic stromal keratitis
    Tomoyuki Inoue
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Cornea 21:106-10. 2002
    ..To evaluate the immunopreventive effect of eyedrops that contain gD-IL-2 DNA (a chimeric gene of the glycoprotein D gene of herpes simplex virus type I (HSV-1) and human interleukin-2 (IL-2) on murine herpetic keratitis...
  19. ncbi Pharmacokinetics of timolol in aqueous humor sampled by microdialysis after topical administration of thermosetting gels
    Gang Wei
    School of Pharmacy, Fudan University, Shanghai 200032, People s Republic of China
    Biomed Chromatogr 20:67-71. 2006
    ..the ocular pharmacokinetics of timolol was studied utilizing microdialysis sampling technique after topical administration. A linear microdialysis probe was characterized and implanted in the anterior chamber of a rabbit...
  20. pmc Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis
    Lorna Mason
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, The Churchill, Headington, Oxford, OX3 7LJ, UK
    BMC Musculoskelet Disord 5:28. 2004
    ..More trials, a better understanding of trial quality and bias, and a reclassification of certain drugs necessitate a new review...
  21. ncbi Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial
    Mary Wells
    School of Nursing and Midwifery, University of Dundee, 11 Airlie Place, Dundee DD1 4HJ, UK
    Radiother Oncol 73:153-62. 2004
    ..This paper presents the results of phase A...
  22. ncbi Topical administration of simvastatin recovers alveolar bone loss in rats
    H Seto
    Department of Periodontology and Endodontology, Oral and Maxillofacial Dentistry, Division of Medico Dental Dynamics and Reconstruction, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Periodontal Res 43:261-7. 2008
    ..Simvastatin, a cholesterol-lowering drug, has been reported to show anabolic effects on bone metabolism. We examined the effects of simvastatin in vitro using cultured rat calvaria cells and in vivo using periodontitis-induced rats...
  23. ncbi Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs
    P Sarasola
    Veterinary Medicine Clinical Development, Pfizer Animal Health Group, Pfizer Ltd, Sandwich, Kent, UK
    J Vet Pharmacol Ther 25:265-72. 2002
    ..18 +/- 0.31 mL/min/kg and 1.24 +/- 0.26 L/kg, respectively, in dogs. After topical administration, the mean C(max) in cats was 5513 +/- 2173 ng/mL reached at a time (T(max)) of 15 +/- 12 h ..
  24. ncbi Skin benefits from continuous topical administration of a zinc oxide/petrolatum formulation by a novel disposable diaper
    S Baldwin
    Procter and Gamble Co, Cincinnati, OH 45242, USA
    J Eur Acad Dermatol Venereol 15:5-11. 2001
    ..Aiming to help reduce the prevalence of this problem, we have advanced in our development of a novel diaper that delivers dermatological formulations to help protect the skin from over-hydration and irritation...
  25. ncbi Topical administration of diclofenac (1%) in the prevention of miosis during vitrectomy
    Ahmad Mirshahi
    Department of Ophthalmology, Tehran University of Medical Sciences Eye Research Center, Tehran, Iran
    Retina 28:1215-20. 2008
    ..A prospective, randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation...
  26. ncbi Antiinflammatory and analgesic activity of topical administration of Siegesbeckia pubescens
    Jianping Wang
    Department of Pharmacognosy, School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    Pak J Pharm Sci 21:89-91. 2008
    ..The results of the present study further confirm the use of Siegesbeckia pubescens traditionally for the treatment of painful inflammatory conditions and can be useful for the treatment of local inflammation...
  27. ncbi Pharmacokinetics and posterior segment biodistribution of ESBA105, an anti-TNF-alpha single-chain antibody, upon topical administration to the rabbit eye
    Esther Furrer
    ESBATech AG, Schlieren, Switzerland
    Invest Ophthalmol Vis Sci 50:771-8. 2009
    The purpose of this study was to characterize local distribution and systemic absorption of the tumor necrosis factor (TNF)-alpha inhibitory single-chain antibody fragment (scFv) ESBA105 following topical administration to the eye in vivo.
  28. ncbi Topical pimecrolimus for skin disease other than atopic dermatitis
    Uwe Wollina
    Department of Dermatology, Academic Teaching Hospital Dresden Friedrichstadt, Germany
    Expert Opin Pharmacother 7:1967-75. 2006
    ....
  29. ncbi Rate and extent of percutaneous absorption of sertaconazole nitrate after topical administration
    Rudy Susilo
    Trommsdorff GmbH and Co Arzneimittel, Research and Development, Alsdorf, Germany
    Arzneimittelforschung 55:338-42. 2005
    ....
  30. ncbi The effect of the topical administration of bioactive glass on inflammatory markers of human experimental gingivitis
    Jörg Eberhard
    Department of Operative Dentistry and Periodontology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 16, 24105 Kiel, Germany
    Biomaterials 26:1545-51. 2005
    ..The topical application of 45S5 bioactive glass in humans with experimental gingivitis attenuated the clinical signs of inflammation, although the bacterial accumulation was not inhibited in this clinical trial...
  31. ncbi Comparison of skin stripping, in vitro release, and skin blanching response methods to measure dose response and similarity of triamcinolone acetonide cream strengths from two manufactured sources
    Lynn K Pershing
    Department of Dermatology, University of Utah School of Medicine, 4B454 SOM, 30 N 1900 E, Salt Lake City, UT 84132, USA
    J Pharm Sci 91:1312-23. 2002
    ..Data support the use of dermatopharmacokinetic methods for bioequivalence and bioavailability assessment of topical drug products...
  32. ncbi Treatment of early pterygium recurrence with topical administration of interferon alpha-2b
    Salomon Esquenazi
    LSU Eye and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Can J Ophthalmol 40:185-7. 2005
  33. ncbi Topical latanoprost and optic nerve head and retinal circulation in humans
    Y Tamaki
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    J Ocul Pharmacol Ther 17:403-11. 2001
    ..Although the mechanism of the increase is unclear, the effects of latanoprost on ONH tissue circulation in humans may have clinical implications...
  34. pmc Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist
    A J Strachan
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland 4072, Australia
    Br J Pharmacol 134:1778-86. 2001
    ..5. This is the first demonstration for either an orally or topically active C5a receptor antagonist, and suggests that small molecule C5a antagonists may have therapeutic utility when given by multiple routes of application...
  35. ncbi Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function
    E Benfeldt
    Department of Dermatology, University of Copenhagen, Gentofte Hospital, Niels Andersensvej 65, DK 2900 Hellerup, Denmark
    Br J Dermatol 140:739-48. 1999
    ..The measured drug penetration was demonstrated to correlate with non-invasive quantification of barrier damage...
  36. ncbi Dermal absorption of permethrin following topical administration
    D Tomalik-Scharte
    Department of Pharmacology, Clinical Pharmacology Unit, University of Cologne, Cologne, Germany
    Eur J Clin Pharmacol 61:399-404. 2005
    ..The objective of this study was to determine the systemic exposure of permethrin and the duration of residence in the human body following topical administration.
  37. ncbi Influence of n-octenylsuccinate starch on in vitro permeation of sodium diclofenac across excised porcine cornea in comparison to Voltaren ophtha
    Luma Baydoun
    Institut fur Pharmazeutische Technologie, Technische Universitat Braunschweig, Braunschweig, Germany
    Eur J Pharm Biopharm 56:73-9. 2003
    ..None of the tested AS formulations showed significantly high haemolytic data. On the other hand the high in vitro haemolysis obtained with VO is primarily based on an osmotic effect caused by boric acid...
  38. pmc Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer
    F Cairnduff
    Academic Unit of Radiotherapy, Cookridge Hospital, Leeds, UK
    Br J Cancer 69:605-8. 1994
    ..Further work is required to improve the results with BCCs...
  39. ncbi Sucralfate cream in the management of moist desquamation during radiotherapy
    G Delaney
    Department of Radiation Oncology, Liverpool Hospital, New South Wales, Australia
    Australas Radiol 41:270-5. 1997
    ..Given the poor accrual in the present, single-institution study, future studies may need to be multi-institutional and we encourage other centres to perform randomized trials in the management of moist desquamation...
  40. ncbi Immunomodulatory therapy in ophthalmology - is there a place for topical application?
    Eckart Bertelmann
    Augenklinik Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Deutschland
    Ophthalmologica 218:359-67. 2004
    ..Taken together, topical immunomodulatory therapy will not replace systemic therapy but further treatment options can be expected...
  41. ncbi Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers
    Hidenobu Tanihara
    Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
    Arch Ophthalmol 126:309-15. 2008
    To investigate the effects and safety of topical administration of an ophthalmic solution of a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, SNJ-1656, 0.003% to 0.1%, in healthy male adult volunteers.
  42. ncbi An open trial of topical tacrolimus for erosive oral lichen planus
    Lynne Morrison
    Department of Dermatology, Oregon Health and Science University, Portland 97201, USA
    J Am Acad Dermatol 47:617-20. 2002
    ..1%. This medication was well tolerated and appears to be effective in controlling erosive oral lichen planus...
  43. ncbi Myocardial ischemia induced by topical use of 5-fluorouracil
    Y Rozenman
    Department of Cardiology, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel
    Int J Cardiol 49:282-3. 1995
    ..Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month...
  44. ncbi Topical tacrolimus (FK506) in the treatment of recalcitrant parastomal pyoderma gangrenosum associated with Crohn's disease: report of two cases
    M Khurrum Baig
    Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida 33331, USA
    Colorectal Dis 6:250-3. 2004
    ..The commonest site is the skin, but sometimes it can occur in the parastomal region. Most of these cases respond to treatment with systemic corticosteroids and cyclosporin or local Kenalog injections...
  45. ncbi Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis
    B V Nusgens
    Laboratory of Connective Tissues Biology, Tour de Pathologie, University of Liege, Sart Tilman, Belgium
    J Invest Dermatol 116:853-9. 2001
    ..The results indicate that the functional activity of the dermal cells is not maximal in postmenopausal women and can be increased...
  46. ncbi Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis
    T Mitsuta
    Department of Oral Rehabilitation and Materials Science, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Periodontol 73:479-86. 2002
    We examined whether topical administration of a bisphosphonate clodronate could prevent alveolar bone loss in rats with experimental periodontitis.
  47. ncbi Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study
    J Hillenkamp
    The Eye Hospital, Heinrich Heine University, Dusseldorf, Germany
    Arch Ophthalmol 119:1487-91. 2001
    ..To evaluate the efficacy of 0.2% cidofovir eyedrops and 1% cyclosporine eyedrops administered 4 times daily (qid) to treat acute adenoviral keratoconjunctivitis...
  48. ncbi Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs
    A C Guidera
    Department of Ophthalmology, Long Island Jewish Medical Center, New Hyde Park, New York, NY, USA
    Ophthalmology 108:936-44. 2001
    ..Potential risk factors include conditions that predispose the patient to corneal melting, concurrent topical steroids, and epithelial keratopathy in the early postoperative period...
  49. ncbi Medical therapies for non-melanoma skin cancer
    Arun Chakrabarty
    Solano Clinical Research, Solano Dermatology Associates, Vallejo, California, USA
    Clin Dermatol 22:183-8. 2004
    ..This preliminary information will expand to include more therapeutic options for NMSC in the future. Further clinical trials are needed to better elucidate possible alternative treatment strategies for NMSC...
  50. ncbi EMLA cream versus dorsal penile nerve block for postcircumcision analgesia in children
    W Y Choi
    Department of Anaesthesia and Intensive Care, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
    Anesth Analg 96:396-9, table of contents. 2003
    ..We conclude that preoperative application of EMLA cream is an effective and simple method to produce postcircumcision analgesia with a very small incidence of adverse effects...
  51. ncbi A case of necrotizing fasciitis due to Streptococcus pneumoniae following topical administration of nonsteroidal anti-inflammatory drugs
    Mona Ben M'rad
    Clin Infect Dis 35:775-6. 2002
  52. ncbi Lipid nanoparticles for improved topical application of drugs for skin diseases
    Monika Schäfer-Korting
    Institut fur Pharmazie, Pharmakologie und Toxikologie, der Freien Universität Berlin, D 14195 Berlin, Germany
    Adv Drug Deliv Rev 59:427-43. 2007
    ..A special focus is upon the interactions of active ingredients and the lipid matrix as well as the quantification of dermal penetration...
  53. ncbi Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery
    Ning Li
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    Int J Pharm 379:131-8. 2009
    ..In conclusion, the LCH coating significantly modified the properties of liposome and brought a series of notable advantages for ocular drug delivery...
  54. ncbi Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma
    Vicente Zanon-Moreno
    Ophthalmologic Research Unit Santiago Grisolia, Dr Peset University Hospital, Valencia Spain
    Eur J Ophthalmol 19:565-71. 2009
    This study deals with the role of the topical administration of dorzolamide eyedrops on the oxidative/antioxidant status of aqueous humor in patients with primary open angle glaucoma (POAG).
  55. ncbi Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
    Sunita Babbar
    NeurogesX, Inc, San Mateo, California 94404, USA
    Ther Drug Monit 31:502-10. 2009
    ..The low systemic exposure and very rapid elimination half-life of capsaicin after NGX-4010 administration are unlikely to result in systemic effects and support the overall safety profile of this investigational cutaneous patch...
  56. ncbi Nanostructured lipid carriers (NLC) in cosmetic dermal products
    R H Muller
    Freie Universitat Berlin, Department of Pharmaceutical Technology, Biopharmaceutics and NutriCosmetics, Kelchstrasse 31, 12169 Berlin, Germany
    Adv Drug Deliv Rev 59:522-30. 2007
    ..An overview of these products is provided including their special effects due to the lipid nanoparticles, lipids used for their production and incorporated cosmetic actives...
  57. ncbi Tear concentrations of azithromycin following topical administration of a single dose of azithromycin 0.5%, 1.0%, and 1.5% eyedrops (T1225) in healthy volunteers
    F Chiambaretta
    Centre de Pharmacologie Clinique, Bâtiment du Centre de Recherche en Nutrition Humaine, Clermont Ferrand, France
    Eur J Ophthalmol 18:13-20. 2008
    ..To evaluate azithromycin tear concentrations after one drop of T1225 0.5%, 1.0%, and 1.5% eyedrops...
  58. ncbi Concentrations of mitomycin C in rabbit corneal tissue and aqueous humor after topical administration
    Jong Suk Song
    Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea
    Cornea 25:S20-3. 2006
    To study the aqueous and corneal pharmacokinetics of mitomycin C (MMC) after single topical administration to the central cornea and to evaluate the effects of different concentrations and different application times on the aqueous ..
  59. ncbi Microemulsions for topical delivery of 8-methoxsalen
    B Baroli
    Department of Farmacia y Tecnologia Farmaceutica, School of Pharmacy, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
    J Control Release 69:209-18. 2000
    ..In order to develop alternative formulations for the topical administration of 8-MOP, microemulsions were evaluated as delivery vehicles...
  60. ncbi Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis
    Olga Millán
    Instituto de Bioquimica, CSIC UCM, 28040 Madrid, Spain
    Carcinogenesis 27:328-36. 2006
    ..These effects mediated by 15dPGJ2 might contribute to understand the role of COX-2 metabolites in carcinogenesis, leading to an increase of cell viability after mutagenic injury and therefore in the progression of tumors...
  61. ncbi Effectiveness of topical administration of opioids in palliative care: a systematic review
    Beata Lebon
    Frimley Park Hospital NHS Foundation Trust, Frimley, Surrey, United Kingdom
    J Pain Symptom Manage 37:913-7. 2009
    ..N-of-1 trials should be encouraged for specific clinical circumstances...
  62. ncbi Effects of systemic or topical administration of sodium selenite on early radiation effects in mouse oral mucosa
    Anja Gehrisch
    Department of Radiotherapy and Radiooncology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Strahlenther Onkol 183:36-42. 2007
    To quantify the effect of sodium selenite (selenium) on radiation-induced oral mucositis (mouse) after subcutaneous or topical administration.
  63. ncbi Topical administration of Caroverine in somatic tinnitus treatment: proof-of-concept study
    Klaus Ehrenberger
    Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Int Tinnitus J 11:34-7. 2005
    ..These results encouraged us to design consequential GCP-conform phase 2 and phase 3 studies...
  64. ncbi Effect of topical tranexamic acid in open heart surgery
    A Abul-Azm
    Department of Cardiothoracic Surgery, Cairo University, Kasr El Ainy Faculty of Medicine, Cairo, Egypt
    Eur J Anaesthesiol 23:380-4. 2006
    ..We have evaluated the effect of the topical use of tranexamic acid in the pericardial cavity on postoperative bleeding following open heart surgery...
  65. ncbi Intraocular penetration of pyruvate following its topical administration in mice
    K R Hegde
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Cell Biochem 338:87-90. 2010
    ..However, with the view of the desirability of treating eye diseases by topical administration of the pharmacological agents, the present studies were conducted to determine the penetrability of ..
  66. ncbi Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds
    Cristina Ribeiro Barros Cardoso
    Laboratory of Immunology, Universidade Federal de Uberlandia, Brazil
    Wound Repair Regen 12:235-43. 2004
    ..Thus, our results suggest a relevant role and potential therapeutic implication for fatty acids on skin wound healing...
  67. ncbi Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy
    S Lombardi Borgia
    Institut fur Pharmazie, Freie Universitat Berlin, Germany
    J Control Release 110:151-63. 2005
    ..Therefore, drug targeting appears to be more strictly related to the mode of interaction of drug and particle than penetration enhancement...
  68. ncbi Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation
    Carmelo Puglia
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Int J Pharm 357:295-304. 2008
    ..Recently, lipid nanoparticles have shown a great potential as vehicle for topical administration of active substances, principally owing to the possible targeting effect and controlled release in ..
  69. ncbi Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans
    Joel W Proksch
    Global Research and Development, Bausch and Lomb, 1400 N Goodman Street, Rochester, NY 14609, USA
    J Ocul Pharmacol Ther 25:335-44. 2009
    ..Studies were conducted to evaluate the ocular penetration and systemic exposure to besifloxacin, a fluoroquinolone antibiotic, following topical ocular administration to animals and humans...
  70. ncbi Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study
    D C Bergmans
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 164:382-8. 2001
    ..cross infection, prevention and control; respiration, artificial, adverse effects; antibiotics, administration and dosage infection control methods; pneumonia, etiology, prevention and control; intubation, intratracheal, adverse effects..
  71. pmc Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial
    Luke C Mullany
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21211, USA
    Lancet 367:910-8. 2006
    ..Omphalitis contributes to neonatal morbidity and mortality in developing countries. Umbilical cord cleansing with antiseptics might reduce infection and mortality risk, but has not been rigorously investigated...
  72. ncbi Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis
    Amir Abrishami
    Department of Anesthesia, Toronto Western Hospital, University Health Network, 2 434 McLaughlin Wing, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Can J Anaesth 56:202-12. 2009
    ..This systematic review aimed to evaluate the efficacy and safety of topical application of antifibrinolytic drugs to reduce postoperative bleeding and transfusion requirements in patients undergoing on-pump cardiac surgery...
  73. pmc How effective is tetracaine 4% gel, before a peripherally inserted central catheter, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [ISRCTN75884221]
    Brigitte Lemyre
    Department of Pediatrics, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    BMC Med 4:11. 2006
    ..The objective of this trial was to assess the safety and efficacy of tetracaine gel on the pain response of very low birth weight (VLBW) infants during insertion of a PICC...
  74. ncbi Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product
    R E B Watson
    Dermatological Sciences Research Group, The University of Manchester, Manchester M13 9PT, UK
    Br J Dermatol 158:472-7. 2008
    ..To date, little is known regarding the ability of over-the-counter 'antiageing' products to repair photoaged skin...
  75. pmc Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Pathol 166:1393-403. 2005
    We evaluated the therapeutic efficacy of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in a corneal alkali burn model in mice...
  76. ncbi Treatment of all basal cell carcinoma variants including large and high-risk lesions with 5% imiquimod cream: histological and clinical changes, outcome, and follow-up
    Claudia Schiessl
    Department of Dermatology and Venereology, Federal University Teaching Hospital, Feldkirch, Austria
    J Drugs Dermatol 6:507-13. 2007
    ..This early imiquimod response might have important implications for the final definition of potentially shorter imiquimod treatment periods...
  77. ncbi Piroxicam nanoparticles for ocular delivery: physicochemical characterization and implementation in endotoxin-induced uveitis
    Khosro Adibkia
    Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
    J Drug Target 15:407-16. 2007
    ..Upon these findings, we propose that the piroxicam:Eudragit RS100 nanosuspensions may be considered as an improved ocular delivery system for locally inhibition of inflammation...
  78. ncbi Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery
    Ilknur Akyol-Salman
    Department of Ophthalmology, Ataturk University Faculty of Medicine, Erzurum, Turkey
    J Ocul Pharmacol Ther 23:280-3. 2007
    ..1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery...
  79. ncbi Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys
    Hideki Tokushige
    Research Laboratories, Senju Pharmaceutical Co Ltd, Kobe, Osaka, Japan
    Invest Ophthalmol Vis Sci 48:3216-22. 2007
    ..To elucidate the intraocular pressure (IOP)-lowering effects and associated characteristics of Y-39983, a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, in animal eyes...
  80. ncbi Chronic hypertrophic acyclovir-resistant genital herpes treated with topical cidofovir and with topical foscarnet at recurrence in an HIV-positive man
    M Ghislanzoni
    J Eur Acad Dermatol Venereol 20:887-9. 2006
  81. ncbi Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California 95616 8542, USA
    J Infect Dis 186:1508-13. 2002
    ..In a subsequent study, 2 oral inoculations of 4 juvenile macaques with a mixture of tenofovir DF and SIVmac251 induced persistent infection. Topical administration of low doses of tenofovir DF did not protect against oral SIV infection.
  82. ncbi Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones
    Babette Biruss
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
    Int J Pharm 328:142-51. 2007
    ..In addition, viscosity measurements were performed. They indicated an influence of the polymers and drugs on the viscosity in all formulations...
  83. ncbi Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose
    Peter F Kador
    College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, Therapeutic Vision Inc, 11778 Whitmore S, Omaha, NE 68142, USA
    Am J Vet Res 67:1783-7. 2006
    ..To determine effects of a topical formulation of an aldose reductase inhibitor (ARI) on the development of sugar cataracts in dogs fed a diet high in galactose. Animals-Ten 6-month old Beagles...
  84. ncbi Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans
    G Atma Vemulakonda
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 126:18-22. 2008
    To determine the penetration of 1% voriconazole solution into the aqueous and vitreous following topical administration.
  85. ncbi Oral versus topical NSAIDs in rheumatic diseases: a comparison
    C A Heyneman
    Department of Pharmacy Practice and Administrative Sciences, Idaho State University College of Pharmacy, Pocatello 83209, USA
    Drugs 60:555-74. 2000
    ..b>Topical administration of NSAIDs offers the advantage of local, enhanced drug delivery to affected tissues with a reduced ..
  86. ncbi [Update in the treatment of herpes zoster]
    Agustín España
    Departamento de Dermatologia, Clinica Universitaria de Navarra, Facultad de Medicina, Spain
    Actas Dermosifiliogr 97:103-14. 2006
    ..Finally, this review discusses treatment guidelines for special locations (cranial nerves) and different subpopulations (children, pregnant women, immunodepressed patients, etc)...
  87. pmc Penetration of chlorhexidine into human skin
    T J Karpanen
    Life and Health Sciences, Aston University, Aston Triangle B4 7ET, United Kingdom
    Antimicrob Agents Chemother 52:3633-6. 2008
    ..This study lays the foundation for further research in adopting alternative strategies for enhanced skin antisepsis in clinical practice...
  88. ncbi Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo
    J M Crowther
    Procter and Gamble Technical Centres Ltd, Rusham Park, Whitehall Lane, Egham, Surrey, TW20 9NW, UK
    Br J Dermatol 159:567-77. 2008
    ....
  89. ncbi Aqueous humor concentration of voriconazole after topical administration in rabbits
    Christian K Vorwerk
    Department of Ophthalmology, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Graefes Arch Clin Exp Ophthalmol 246:1179-83. 2008
    ..and Aspergillus spp. which are frequent causes of fungal keratitis depending on geographic location. We investigated the penetration of voriconazole through the cornea into the aqueous humor (AH) after topical administration.
  90. ncbi Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea
    Zoe Diana Draelos
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cutis 76:135-41. 2005
    ..Instruments provided objective measures of stratum corneum barrier function and hydration on the face...
  91. ncbi Penetration of topically applied ciprofloxacin and ofloxacin into the aqueous humor and vitreous
    Ilgaz Sagdic Yalvac
    Department of Ophthalmology, Ankara Hospital, Hacettepe University, Ankara, Turkey
    J Cataract Refract Surg 29:487-91. 2003
    ..3% and ofloxacin 0.3%, into the aqueous humor and vitreous and to relate these levels to the miminum inhibitory concentration (MIC(90)) for organisms associated with ocular bacterial infections...
  92. pmc Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema
    John Doukas
    TargeGen, Inc, San Diego, California
    J Cell Physiol 216:29-37. 2008
    ..These data suggest that TG100801 may provide a new topically applied treatment approach for ocular neovascularization and retinal edema...
  93. ncbi Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement
    Anna Taddio
    Department of Pharmacy, The Hospital for Sick Children, Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario
    JAMA 295:793-800. 2006
    ..There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness...
  94. ncbi Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca
    Bradley Strong
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cornea 24:80-5. 2005
    ..The purpose of this study is to determine if topical CsA treatment inhibits conjunctival epithelial apoptosis in a murine model of KCS...
  95. ncbi Comparison of invasive and non-invasive tonometry in the mouse
    Christy A Morris
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
    Exp Eye Res 82:1094-9. 2006
    ..Despite these limitations, the rebound tonometer has a significant advantage over cannulation tonometry in that it permits longitudinal IOP measurement in conscious mice...
  96. pmc The development of Cutina lipogels and gel microemulsion for topical administration of fluconazole
    H M El Laithy
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    AAPS PharmSciTech 3:E35. 2002
    ..05). The antifungal activity of fluconazole showed the widest zone of inhibition with gel microemulsion. The gel microemulsion is an excellent vehicle for fluconazole topical drug delivery...
  97. ncbi Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen
    Rosario Pignatello
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Catania, Citta Universitaria, Viale A Doria, 6 95125, Catania, Italy
    Eur J Pharm Sci 16:53-61. 2002
    ..Drug levels in the aqueous humour were also higher after application of the nanosuspensions; moreover, IBU-loaded nanosuspensions did not show toxicity on ocular tissues...
  98. ncbi Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacol Ther 71:153-61. 2002
    ..To achieve optimal therapeutic effects, ultraviolet A irradiation should be performed at the time of maximum photosensitivity, that is, at the time of maximum 8-methoxypsoralen tissue concentrations...
  99. ncbi Symmetry of fellow-eye intraocular pressure responses to topical glaucoma medications
    Tony Realini
    Department of Ophthalmology, West Virginia University Eye Institute, Morgantown, West Virginia 26506, USA
    Ophthalmology 112:599-602. 2005
    ..The purpose of this study was to determine if this assumption is true...
  100. ncbi Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration
    S A Wissing
    Department of Pharmaceutics, Biopharmaceutics and Biotechnology, The Free University of Berlin, Kelchstrasse 31, D 12169 Berlin, Germany
    J Control Release 81:225-33. 2002
    ..The rate of release also depends upon the total concentration of oxybenzone in the formulation. In vitro-in vivo correlations could be made qualitatively...
  101. ncbi Transcutaneous absorption of oil in preterm babies--a pilot study
    A R Fernandez
    Department of Neonatology, L T M G Hospital and L T M M College, Sion, Mumbai, India
    Indian Pediatr 42:255-8. 2005
    ..The post oil application serum sample of all the 12 babies showed the presence of marker fatty acids of Meadowfoam oil which indicates transcutaneous absorption of oil in preterm babies...

Research Grants62

  1. Nanospheres as Delivery Vehicles for Psoriasis Therapeutics
    LARISA contact SHEIHET; Fiscal Year: 2010
    ..The nanosphere design is highly versatile and will significantly contribute to topical drug delivery applications. ..
  2. PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROME
    SAMUEL HOPKINS; Fiscal Year: 2005
    ..finding, coupled with the scientific rationale presented above, provides support for the hypothesis that topical administration of 552 will inhibit the transport of sodium through the epithelial sodium channel and at the same time ..
  3. OCULAR CANNABINOID EFFECTS
    Gregory Liou; Fiscal Year: 2001
    ..b>Topical administration of an efficacious cannabinoid in a delivery vehicle that enhances ocular penetration would be desirable...
  4. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..While these observations suggest a new therapeutic based on this approach, the topical administration of this material may not allow penetration across the tissue in the wound as reepithelialization occurs...
  5. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    ..Our goal is to develop the novel approach of UV protection by sunless tanning based on topical administration of this root extract or small molecule derivatives...
  6. A novel therapeutic approach for pressure ulcers
    EDWARD PAUL MONAGHAN; Fiscal Year: 2012
    ..spectrometry to determine the pharmacokinetic profile of ARN077 following acute or prolonged topical administration in mice...
  7. siRNA-gold nanoparticle mediated ganglioside depletion for diabetic wound healing
    AMY SUSAN PALLER; Fiscal Year: 2013
    ..In addition, reversal of the wound healing defect in obese diabetic mice by topical administration of our nanoparticle-conjugated nucleic acid inhibitors of ganglioside synthesis will be an innovative ..
  8. Novel modalities for assessing the cortical tissue-electrode interface
    Jeffrey R Capadona; Fiscal Year: 2010
    ..The technique will first be validated through topical administration to excised brains having previously received an implanted electrode...
  9. A Topical Host Defense Peptide Mimetic for Oral Mucositis
    Richard W Scott; Fiscal Year: 2012
    ..in which the severity and course of radiation-induced mucosal injury were dramatically altered after topical administration of three PMX mimics, including our lead compound PMX30063...
  10. A transfollicular nanovaccine against leishmaniasis
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2012
    ..We also hypothesize that the topical administration of this nanovaccine will induce a LACK-specific T cell response...
  11. Topical Nanoparticles for CNV
    Uday B Kompella; Fiscal Year: 2010
    ..this project is aimed at investigating the feasibility of using a nanoparticle technology of NanoTrans for topical administration of a model drug diclofenac, for the management of choroidal neovascularization...
  12. The role of PPAR{gamma} ligands in corneal wound healing and optics
    Krystel R Huxlin; Fiscal Year: 2013
    ..We will perform binocular PRK in cats followed by the topical administration of select PPAR3 ligands, anti-TGF2 antibodies, steroids or Mitomycin C...
  13. Restoration of Skin Structure and Function Post-Wounding
    GAUTAM SUDHIR GHATNEKAR; Fiscal Year: 2010
    ..2a) To determine pharmacokinetic (PK) characteristics of the peptide after topical administration in rats. 2b) To determine acute toxicity of ACT1 peptide after intravenous (IV) administration in rats...
  14. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
    ..The specific aims are to evaluate the efficacy and safety of exogenous topical administration of various prostaglandin (PG) derivatives for glaucoma therapy, and to determine the role of endogenously-..
  15. Stimulation of Tear Secretion by a Novel Glycoprotein
    John Sheppard; Fiscal Year: 2009
    ..Specific aims include (1) Optimal increased tear production with minimal adverse reactions after topical administration in an in vivo rabbit dry eye model, (2) Determination of basic parameters of lacritin absorption, ..
  16. Vasoactive intestinal peptide for the treatment of psoriasis
    Sandra Reichstetter; Fiscal Year: 2013
    ..In the proposed project, we will collect data about bioavailability of VIP after s.c. and topical administration, and, as VIP can decrease the arterial blood pressure, measure the blood pressure in the tail of VIP ..
  17. Controlling the Source of Inflammatory Signaling in a Burn Model
    Saman Arbabi; Fiscal Year: 2012
    ..injury model, we will investigate the interaction between dermal and systemic inflammatory response by topical administration of inhibitors of intracellular stress signaling to the burn wound...
  18. Molecular mechanisms of pulsed dye laser combined with topical rapamycin for port
    Wenbin Tan; Fiscal Year: 2013
    ..rationale for this strategy (PDL+RPM) is that PDL is used to induce PWS blood vessel injury while topical administration of RPM can inhibit reformation and reperfusion of PWS blood vessels after laser exposure...
  19. Electropulsation mediated drug therapy for Onychomycosis
    SATHYANARAYANA MURTHY; Fiscal Year: 2009
    ..They are currently treated by oral and topical administration of the antifungal drugs...
  20. RIBONUCLEOTIDE REDUCTASE: TARGET FOR ORAL HERPES CONTROL
    STEVEN TURK; Fiscal Year: 1991
    ....
  21. TOPICAL THIOSEMICARBAZONES FOR CONTROL OF ORAL HERPES
    CHARLES SHIPMAN; Fiscal Year: 1991
    ....
  22. TOPICAL DRUG DELIVERY FOR GASTRIC H. PYLORI INFECTION
    Catherine Woods; Fiscal Year: 2000
    ..A vehicle for topical administration of antibiotics directly to the gastric mucus layer may provide an enhanced method for H...
  23. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..In a second series of experiments we will examine whether the topical administration to the tissues of the respiratory tract of other suppressing agents (budesonide- epigallocatechin gallate (..
  24. ANTIANGIOGENESIS BY THYMIDINE PHOSPHORYLASE INHIBITORS
    George Wright; Fiscal Year: 1999
    ..of a potent inhibitor of PD-ECGF/TP to block angiogenesis in the mouse corneal micropocket assay following topical administration. (4) To synthesize hydrophilic and/or salt-forming, water soluble derivatives of the best lead compound ..
  25. SYSTEMIC AND OCULAR DELIVERY OF NOVEL ARIS
    Uday Kompella; Fiscal Year: 1999
    ..Although prevention of cataract by ARIs following topical administration has been reported, majority of studies conducted thus far administered ARIs orally...
  26. Kinetics of Drug Penetration Across the Cornea at a Microscopic Level
    SANGLY SRINIVAS; Fiscal Year: 2009
    ..The resulting model will then be employed to predict pharmacokinetics for topical administration of the fluorescent drug analogs...
  27. NOVEL DELIVERY SYSTEM FOR TOPICAL ANESTHESIA
    Bakul Bhatt; Fiscal Year: 2000
    ..patented skin coating drug delivery system to establish effective delivery of local anesthetics via topical administration. In order to demonstrate the feasibility of this approach, the Specific Aims are to optimize the coating ..
  28. A mammalian expression system to produce human S-lgA
    Koteswara Chintalacharuvu; Fiscal Year: 2006
    ..in clinical trials are for systemic administration, the greatest potential for antibodies lies in their topical administration for both prevention and treatment of infectious diseases at the mucosal surfaces...
  29. New Topical Therapies for Psoriasis
    Mitchell Avery; Fiscal Year: 2007
    ..art animal models of psoriasis and are performing toxicology studies to determine the safety profile with topical administration. In addition, we are exploring the potential of this agent for use in treatment of other inflammatory skin ..
  30. TOPICAL DELIVERY OF AMINOLEVULINIC ACID IN PDT FOR BASAL
    Kenneth Norbury; Fiscal Year: 2000
    ..Previously, photodynamic therapy in conjunction with topical administration of photosensitizers has been used in the treatment of BCC...
  31. New Topical Therapies for Psoriasis
    Harrihar Pershadsingh; Fiscal Year: 2004
    ..If we find that topical administration of thiazolidinediones can promote the more orderly epidermal differentiation of psoriatic skin in vitro ..
  32. TREATMENT OF PSORIASIS WITH PARATHYROID HORMONE (1-34)
    Michael Holick; Fiscal Year: 2000
    ..The goal of this pilot study is to determine the therapeutic efficacy and safety of the topical administration of the PTHrP/PTH receptor agonist PTH (1-34) for the treatment of plaque psoriasis in adults...
  33. TOPICAL DRUGS FOR THE TREATMENT OF PSORIASIS
    HARLIE PARISH; Fiscal Year: 1992
    ..One of the goals of this application is to modify benoxaprofen for topical administration which should result in high concentrations at the lesion site, lower concentrations systemically, and ..
  34. Stimulation of Tear Secretion by a Novel Glycoprotein
    John Sheppard; Fiscal Year: 2004
    ..demonstration, using an in vivo rabbit model, of the ability of lacritin to increase tear production after topical administration, (2) determination of the effect of lacritin on the normal composition of tears, and (3) examination of ..
  35. FGFs to Broadly Protect Chemotherapy-Induced Alopecia
    Ze Lu; Fiscal Year: 2005
    ..Collectively, our preliminary results suggest that liposomal formulations of FGFs for topical administration can selectively protect against CIA without compromising the effectiveness of chemotherapy...
  36. HETEROGENEITY OF LYMPHOCYTES IN HERPES OCULAR DISEASE
    Rose Nagy; Fiscal Year: 1980
    Rabbit corneas were infected with Herpes simplex virus (HSV) by two routes: either by topical administration of virus to abraded corneas or by intra-corneal injections of low doses of HSV...
  37. Endoscopically-guided optical coherence tomography for early cancer screening
    Nicusor Iftimia; Fiscal Year: 2009
    ..tested on various colon cancer cell lines in cultures and in an orthotopic human colon model in mice upon topical administration. The Phase I results and observations will be used to improve the technology in Phase II...
  38. MACROPHAGE FUNCTION IN ACUTE WOUND REPAIR
    LUISA DIPIETRO; Fiscal Year: 1999
    ..the second series of experiments, the production of each of these angiogenic modulators will be blocked by topical administration of specific anti sense oligonucleotides to healing wounds...
  39. ADENOSINE 3 LIGANDS EXPERIMENTAL THERAPY OF UVEITIS
    ABDELKARIM GAELDIN; Fiscal Year: 2000
    ..of the proposed studies is determination of the dosage, timing and route of administration--in particular, topical administration--of the A3 agonist in the treatment of EIU...
  40. Artificial Cornea Based on Photolithographically Patterned, Biomimetic Hydrogels
    Christopher N Ta; Fiscal Year: 2010
    ..3. Determine the skirt design for optimal stromal tissue integration by evaluating in vitro and in vivo stromal wound healing within photolithographically patterned, microperforated hydrogel arrays. ..
  41. Gene Gun Technology, Opioids, and Corneal Diseases
    IAN ZAGON; Fiscal Year: 2003
    ..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
  42. Topical virucides to prevent oral transmission
    Koen van Rompay; Fiscal Year: 2004
    ..If topical tenofovir administration were effective, then this simple strategy would be highly affordable for developing countries. ..
  43. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  44. SKIN SELF EXAMINATION FOR EARLY DETECTION OF MELANOMA
    Martin Weinstock; Fiscal Year: 2002
    ..The knowledge and experiment thus gained will aid the continuing efforts to encourage SSE and reduce melanoma mortality. ..
  45. IMMUNOGENETICS AND THE PATHOGENESIS OF RSV INFECTION
    John DeVincenzo; Fiscal Year: 2004
    ..With the help of this award, this goal can be achieved. ..
  46. Mast Cells: Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2007
    ..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. [unreadable] [unreadable] [unreadable]..
  47. Efficacy of Web-based Training in Skin Cancer Triage
    Martin Weinstock; Fiscal Year: 2007
    ..If this course is found to be efficacious, it will be made freely available on the web, and we will plan efforts to encourage its broad dissemination. [unreadable] [unreadable]..
  48. Incidence, risk factors, and consequences of neonatal hypothermia in Nepal
    LUKE MULLANY; Fiscal Year: 2008
    ..Examination of alternate cutoffs for defining hypothermia severity may improve design of low-cost technologies for identification and subsequent management of hypothermic infants in the community. [unreadable] [unreadable] [unreadable]..
  49. High Dose Nicotine Patch Therapy for Spit Tobacco Users
    Jon Ebbert; Fiscal Year: 2004
    ..Our goal is to reduce the prevalence of ST use and decrease the incidence of oropharyngeal cancer through the development of effective treatment options for ST users. ..
  50. Dendritic cell defects in cutaneous T-cell lymphoma
    Alain Rook; Fiscal Year: 2007
    ..abstract_text> ..
  51. PHONATION AND PHONATORY CONTROL IN VOCAL TREMORS
    Marshall Smith; Fiscal Year: 2002
    ..The experimental phase consists of studies of neuromuscular and respiratory input to the larynx. This information about vocal tremor will be applied to model simulations with the use of physiological signals as input model parameters. ..
  52. MEIBOMIAN KERATOCONJUNCTIVITIS
    James McCulley; Fiscal Year: 2003
    ..Methods include non-destructive HPLC as well as GC-MS to analyze patient meibum, and standard lipid mixtures based on the composition of patient meibum for physical measurements. ..
  53. Describing and Measuring Tobacco Treatment in Drug Treatment
    Kimber Richter; Fiscal Year: 2008
    ..Project findings will support future policy and research to strengthen tobacco treatment services in substance abuse treatment. [unreadable] [unreadable] [unreadable]..
  54. Who drives safely? Visual/cognitive predictors in Elders
    Sheila West; Fiscal Year: 2008
    ..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
  55. Peroxynitrate neutralizing agents for stroke therapy
    Csaba Szabo; Fiscal Year: 2003
    ....
  56. Carbonyl scavengers for skin protection from glycation
    ELAINE JACOBSON; Fiscal Year: 2003
    ....
  57. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  58. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..
  59. Evaluating Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
    Jon Ebbert; Fiscal Year: 2009
    ..No drug therapies have been shown to be effective for helping smokeless tobacco users quit for good. The purpose of this study is to test drugs that can be used to help smokeless tobacco users quit for good. ..
  60. 6th International Skin Carcinogenesis Conference
    Susan Fischer; Fiscal Year: 2004
    ..The meeting will be held jointly with the Montagna Symposium on the Biology of Skin. ..
  61. ROLE OF PGE2 RECEPTORS EP2 AND EP3 ON SENESCENCE
    Raymond Konger; Fiscal Year: 2004
    ..These studies will underscore how alterations of receptor expression serve to define the role of eicasonoids in diverse cellular functions. ..
  62. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2006
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..