phonophoresis

Summary

Summary: Use of ultrasound to increase the percutaneous adsorption of drugs.

Top Publications

  1. ncbi Diclofenac phonophoresis in human volunteers
    Giovana C Rosim
    Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto School of Medicine, Sao Paulo University, Ribeirao Preto SP, Brazil
    Ultrasound Med Biol 31:337-43. 2005
  2. ncbi Low-frequency sonophoresis: a review
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Adv Drug Deliv Rev 56:589-601. 2004
  3. ncbi Dermal and transdermal drug delivery systems: current and future prospects
    Marc B Brown
    Pharmaceutical Sciences Research Division, King s College London and MedPharm Ltd, London, United Kingdom
    Drug Deliv 13:175-87. 2006
  4. ncbi Frequency dependence of sonophoresis
    A Tezel
    Department of Chemical Engineering, University of California Santa Barbara, California 93106, USA
    Pharm Res 18:1694-700. 2001
  5. ncbi Phonophoresis: efficiency, mechanisms and skin tolerance
    L Machet
    Department of Dermatology, University Hospital, F 37044 Tours Cedex 01, France
    Int J Pharm 243:1-15. 2002
  6. ncbi Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis
    Erkan Kozanoglu
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova Unviersity, Adana, Turkey
    Swiss Med Wkly 133:333-8. 2003
  7. ncbi In vitro phonophoresis: effect of ultrasound intensity and mode at high frequency on NSAIDs transport across cellulose and rabbit skin membranes
    M M Meshali
    Department of Pharmaceutics, College of Pharmacy, Mansoura University, Mansoura, Egypt
    Pharmazie 63:49-53. 2008
  8. doi Effect of gel composition and phonophoresis on the transdermal delivery of ibuprofen: in vitro and in vivo evaluation
    Mahasen Meshali
    Mansoura University, Mansoura, Egypt
    Pharm Dev Technol 16:93-101. 2011
  9. doi The effects of pressure release, phonophoresis of hydrocortisone, and ultrasound on upper trapezius latent myofascial trigger point
    Javad Sarrafzadeh
    Tehran University of Medical Sciences, Tehran, Iran
    Arch Phys Med Rehabil 93:72-7. 2012
  10. ncbi Phonophoresis versus ultrasound in the treatment of common musculoskeletal conditions
    M D Klaiman
    Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, USA
    Med Sci Sports Exerc 30:1349-55. 1998

Research Grants

  1. Ultrasonic assessment of therapeutic response
    Katherine W Ferrara; Fiscal Year: 2010
  2. Prostate Cancer Prevention by Pachymic Acid
    Lawrence Ng; Fiscal Year: 2006
  3. CONTRAST ASSISTED ULTRASOUND IMAGING OF TUMORS
    Katherine Ferrara; Fiscal Year: 2006
  4. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006
  5. Engineering Approaches to Molecular Imaging Training
    Katherine Ferrara; Fiscal Year: 2007
  6. Ultrasound Imaging and Local Drug Delivery in Tumors
    Katherine Ferrara; Fiscal Year: 2007
  7. Ultrasound Imaging and Local Drug Delivery in Tumors
    Katherine W Ferrara; Fiscal Year: 2010
  8. Ultrasonic assessment of therapeutic response
    Katherine Ferrara; Fiscal Year: 2009
  9. Ultrasound Imaging and Local Drug Delivery in Tumors
    Katherine Ferrara; Fiscal Year: 2009
  10. High Resolution Ultrasound cancer Imaging
    Katherine Ferrara; Fiscal Year: 2009

Detail Information

Publications119 found, 100 shown here

  1. ncbi Diclofenac phonophoresis in human volunteers
    Giovana C Rosim
    Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto School of Medicine, Sao Paulo University, Ribeirao Preto SP, Brazil
    Ultrasound Med Biol 31:337-43. 2005
    A quantitative study of sodium diclofenac (Voltaren Emulgel, Novartis) phonophoresis was undertaken in humans...
  2. ncbi Low-frequency sonophoresis: a review
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Adv Drug Deliv Rev 56:589-601. 2004
    ..Mechanistic insights gained through a number of investigations are also reviewed. Finally, reports on the synergistic effect of low-frequency ultrasound with other enhancers including chemicals and iontophoresis are summarized...
  3. ncbi Dermal and transdermal drug delivery systems: current and future prospects
    Marc B Brown
    Pharmaceutical Sciences Research Division, King s College London and MedPharm Ltd, London, United Kingdom
    Drug Deliv 13:175-87. 2006
    ..This article provides a detailed review of the next generation of active delivery technologies...
  4. ncbi Frequency dependence of sonophoresis
    A Tezel
    Department of Chemical Engineering, University of California Santa Barbara, California 93106, USA
    Pharm Res 18:1694-700. 2001
    ..9 kHz). CONCLUSIONS: This study provides a quantitative understanding of the effects of low-frequency ultrasound on skin permeability...
  5. ncbi Phonophoresis: efficiency, mechanisms and skin tolerance
    L Machet
    Department of Dermatology, University Hospital, F 37044 Tours Cedex 01, France
    Int J Pharm 243:1-15. 2002
    b>Phonophoresis or sonophoresis is the use of ultrasound to increase percutaneous absorption of a drug. The technique has been widely used in sports medicine since the sixties...
  6. ncbi Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis
    Erkan Kozanoglu
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova Unviersity, Adana, Turkey
    Swiss Med Wkly 133:333-8. 2003
    To compare the effectiveness of ibuprofen phonophoresis (PH) with conventional ultrasound (US) therapy in knee osteoarthritis.
  7. ncbi In vitro phonophoresis: effect of ultrasound intensity and mode at high frequency on NSAIDs transport across cellulose and rabbit skin membranes
    M M Meshali
    Department of Pharmaceutics, College of Pharmacy, Mansoura University, Mansoura, Egypt
    Pharmazie 63:49-53. 2008
    ..This study demonstrated the therapeutic potential of ultrasound in transdermal delivery of NSAIDs and the synergistic effect of temperature and ultrasound operational parameters on drug transport...
  8. doi Effect of gel composition and phonophoresis on the transdermal delivery of ibuprofen: in vitro and in vivo evaluation
    Mahasen Meshali
    Mansoura University, Mansoura, Egypt
    Pharm Dev Technol 16:93-101. 2011
    ..Nonetheless, in addition to ultrasound, the composition of the gel is expected to have a significant effect on the transdermal delivery of drugs...
  9. doi The effects of pressure release, phonophoresis of hydrocortisone, and ultrasound on upper trapezius latent myofascial trigger point
    Javad Sarrafzadeh
    Tehran University of Medical Sciences, Tehran, Iran
    Arch Phys Med Rehabil 93:72-7. 2012
    To compare the effects of pressure release (PR), phonophoresis of hydrocortisone (PhH) 1%, and ultrasonic therapy (UT) in patients with an upper trapezius latent myofascial trigger point (MTP).
  10. ncbi Phonophoresis versus ultrasound in the treatment of common musculoskeletal conditions
    M D Klaiman
    Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, USA
    Med Sci Sports Exerc 30:1349-55. 1998
    The purpose of this study was to determine whether the pain response after phonophoresis (PH) differs from the pain response after ultrasound (US) alone.
  11. pmc Phonophoresis and the absorption of dexamethasone in the presence of an occlusive dressing
    Susan Saliba
    Athletic Training and Sports Medicine, University of Virginia, 210 Emmet Street South, PO Box 400407, Charlottesville, VA 22904 4269, USA
    J Athl Train 42:349-54. 2007
    b>Phonophoresis is purported to represent a method to apply topical medications through the skin to treat soft tissue injuries and inflammatory conditions. Few data are available to demonstrate the clinical effectiveness of the treatment.
  12. doi Effects of therapeutic pulsed ultrasound and dimethylsulfoxide (DMSO) phonophoresis on parameters of oxidative stress in traumatized muscle
    Paulo C L Silveira
    Laboratório de Fisiologia e Bioquímica do Exercício PPGCS UNESC Criciúma, SC Brazil
    Ultrasound Med Biol 36:44-50. 2010
    ..b>Phonophoresis aims to achieve therapeutically relevant concentrations of the transdermally introduced drug in the tissues ..
  13. doi Effects of phonophoresis with Arnica montana onto acute inflammatory process in rat skeletal muscles: an experimental study
    Patrícia P Alfredo
    Postgraduate Program, Department of Speech, Physical and Occupational Therapy, Medicine School, University of Sao Paulo, Gioconda Mussolini 23, Edif Felipe apto 11, Jardim Risso, 05587 120 São Paulo, SP, Brazil
    Ultrasonics 49:466-71. 2009
    This study aimed at verifying the effects of phonophoresis associated with Arnica montana on the acute phase of an inflammatory muscle lesion...
  14. ncbi Comparison of effects of phonophoresis and iontophoresis of naproxen in the treatment of lateral epicondylitis
    Ferdi Baskurt
    Dokuz Eylul University School of Physical Therapy, Izmir, Turkey
    Clin Rehabil 17:96-100. 2003
    The aim of this study was to compare the effectiveness of naproxen (10%) applied by topical iontophoresis or by phonophoresis in the treatment of lateral epicondylitis.
  15. ncbi Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats
    Yueh Ling Hsieh
    Department of Physical Therapy, Hung Kuang University, Taichung, 34, Chung Chie Road, Sha Lu, Taichung 433, Taiwan, Republic of China
    Phys Ther 86:39-49. 2006
    The direct effects of ultrasound (US) and phonophoresis of a nonsteroidal anti-inflammatory drug (NSAID) on injured peripheral tissue have been widely investigated, but evidence concerning the effects of central spinal nociceptive ..
  16. ncbi Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma levels
    Barbara Cagnie
    Department of Rehabilitation Sciences and Physical Therapy, Ghent University Hospital, De Pintelaan 185, 6K3, B 9000 Ghent, Belgium
    Phys Ther 83:707-12. 2003
    ..of ultrasound has been attempted to enhance transdermal transport of several drugs, a method referred to as "phonophoresis." The purposes of this study were to examine the influence of ultrasound on the transdermal delivery of ..
  17. ncbi Transdermal delivery system of triamcinolone acetonide from a gel using phonophoresis
    Jae Heon Yang
    Department of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Arch Pharm Res 29:412-7. 2006
    ..the transdermal delivery system for TA, a hydrophilic carbopol gel containing TA was prepared after adopting phonophoresis. A permeation study through mouse skin was performed at 37 degrees C using a Franz diffusion cell, and the ..
  18. ncbi Comparative study of the efficacy of the topical application of hydrocortisone, therapeutic ultrasound and phonophoresis on the tissue repair process in rat tendons
    Paulo Umeno Koeke
    Program of Post Graduation Interunits in Bioengineering, University of Sao Paulo, Sao Paulo, Brazil
    Ultrasound Med Biol 31:345-50. 2005
    ..to compare the treatment efficacy of topical application of hydrocortisone, therapeutic ultrasound (US) and phonophoresis on the rat's Achilles tendon (tendo calcaneus) repair process after tenotomy...
  19. ncbi Enhancing transdermal drug transport with low-frequency ultrasound
    Ka Yun Ng
    University of Colorado Health Sciences Center, Department of Pharmaceutical, 4200 East 9th Avenue, C 238, Denver, CO 80262, USA
    Drug Discov Today 9:913. 2004
  20. ncbi Ultrasound, microbubbles and the blood-brain barrier
    Stephen Meairs
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Prog Biophys Mol Biol 93:354-62. 2007
    ..It also discusses possible roles of the BBB in brain disease and potential interactions with ultrasound and microbubbles in such disease states...
  21. ncbi Sonophoresis-mechanisms and application
    Edina Vranić
    Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Cekalusa 90, Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 4:25-32. 2004
    ..One of them is sonophoresis (phonophoresis)...
  22. ncbi Influence of ultrasound on the percutaneous absorption of ketorolac tromethamine in vitro across rat skin
    Sandip B Tiwari
    Department of Novel Drug Delivery Systems, Zydus Research Centre, Ahmedabad, Gujarat, India
    Drug Deliv 11:47-51. 2004
    ..Pretreatment of skin by 5% d-limonene in ethanol for 2 hr followed by sonication at 3 W/cm2 (30 min) significantly enhanced the permeation of ketorolac when compared with passive flux with or without enhancer pretreatment...
  23. ncbi Low-frequency sonophoresis: ultrastructural basis for stratum corneum permeability assessed using quantum dots
    Sumit Paliwal
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    J Invest Dermatol 126:1095-101. 2006
    ..This contention is consistent with previously conceived theoretical mechanistic understanding of LFS-induced enhanced transport across the skin...
  24. ncbi Dependence of low-frequency sonophoresis on ultrasound parameters; distance of the horn and intensity
    T Terahara
    Department of Chemical Engineering, Massachusetts Institute of Technology E25 342, 45 Carlton St, Cambridge, MA 02139, USA
    Int J Pharm 235:35-42. 2002
    ..Overall, the dependence of transport on ultrasound parameters is similar to that of aluminum foil pitting. These results support the role of cavitation in low-frequency sonophoresis...
  25. ncbi Application of liposomes to sonoporation
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405 0125, USA
    Ultrasound Med Biol 32:429-37. 2006
    ..2 MHz (the in situ spatial peak-pressure amplitude = 80 W/cm2) with an efficiency of 13 %. It has been experimentally shown that liposomes may be an alternative stable agent to Optison for delivering macromolecules into cells...
  26. ncbi Nonablative resurfacing
    Ranella J Hirsch
    Skincare Doctors, Cambridge, MA 02138, USA
    Facial Plast Surg 20:57-61. 2004
    ..It is also ideally suited for those patients seeking a minimally invasive, greatly reduced downtime procedure...
  27. ncbi Effective tumor treatment using optimized ultrasound-mediated delivery of bleomycin
    John O Larkin
    Cork Cancer Research Centre, Leslie C Quick Laboratory, University College Cork, Cork, Ireland
    Ultrasound Med Biol 34:406-13. 2008
    ..This technique could be used with focused ultrasound or with endoscopic ultrasound probes to develop a localized and effective anticancer treatment with little or no systemic toxicity. (E-mail: Geraldc@ccrc.ie)...
  28. ncbi Shear stress in cells generated by ultrasound
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Prog Biophys Mol Biol 93:363-73. 2007
    ..Numerical calculations have shown that shear stress associated with microstreaming surrounding encapsulated bubbles may be large enough to generate sonoporation at 0.1 MPa of 1 or 2 MHz ultrasound...
  29. ncbi [Study of changes in the enzyme-salt composition affecting the permeability of ocular tissues under infrasound phonophoresis]
    V V Filatov
    Vestn Oftalmol 121:26-8. 2005
    This paper deals with the study of infrasound phonophoresis-induced changes in biochemical factors, which affect the permeability of eyeball tissues...
  30. ncbi Determination of sensitive electrophysiologic parameters at follow-up of different steroid treatments of carpal tunnel syndrome
    Recep Aygul
    Department of Neurology, Ataturk University Faculty of Medicine, Erzurum, Turkey
    J Clin Neurophysiol 22:222-30. 2005
    ..The aim of this study was to compare the efficacy of local corticosteroid injection, phonophoresis, and iontophoresis for the treatment of CTS, and to evaluate the most sensitive electrophysiologic parameters ..
  31. ncbi Is there a role for ultrasound and electrical stimulation following injury to tendon and nerve?
    Susan L Michlovitz
    Department of Physical Therapy, Temple University, Philadelphia, Pennsylvania 19140, USA
    J Hand Ther 18:292-6. 2005
    ..with dexamethasone sodium phosphate can relieve pain in acute elbow tendonitis, but there is no support for phonophoresis for any tendonitis...
  32. ncbi Rotator cuff impingement
    Mario Pribicevic
    Macquarie University, Ryde, NSW, Australia
    J Manipulative Physiol Ther 27:580-90. 2004
    ..To present a case of shoulder impingement syndrome managed with a conservative multimodal treatment approach...
  33. ncbi [Prophylactics and treatment of pyo-inflammatory complications after appendectomy]
    A E Borisov
    Vestn Khir Im I I Grek 163:53-5. 2004
    ..in the wound after operation of appendectomy with the help of mid-frequency ultrasound with dioxidin as phonophoresis allows to make suppurations in the postoperative patients 5...
  34. ncbi Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra
    Eva K Lee
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 51:82-9. 2004
    ..These rules and the methods used to derive them could be used for real-time feedback about ultrasound's biological effects...
  35. doi Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice
    Alfia Khaibullina
    Department of Radiology, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 49:295-302. 2008
    ..The aim of this study was to determine if pulsed high-intensity focused ultrasound (HIFU) exposures could enhance tumor uptake of (111)In-MX-B3, a murine IgG1kappa monoclonal antibody directed against the Le(y) antigen...
  36. ncbi Transdermal approaches to pain in sports injury management
    Delmas J Bolin
    The Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Sports Medicine, 112 Merryman Center, Blacksburg, VA 24061, USA
    Curr Sports Med Rep 2:303-9. 2003
    ..These include cryotherapy, laser treatments, electrical stimulation, ultrasound and phonophoresis, extracorporeal shock wave therapy, and iontophoresis...
  37. ncbi An introduction to physical therapy modalities
    Brenda L Chapman
    Sports Medicine Clinic, Western Michigan University, 1903 West Michigan Avenue, Kalamazoo, MI 49008 5445, USA
    Adolesc Med State Art Rev 18:11-23, vii-viii. 2007
    ..The commonly used modalities reviewed here include heat, cold, ultrasound, phonophoresis, iontophoresis, and electrical stimulation...
  38. doi Treatment of chronic rhinosinusitis using erythromycin phonophoresis
    Noureddin Nakhostin Ansari
    Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
    Physiother Theory Pract 29:159-65. 2013
    ..ultrasound enhances the breakdown of bacterial biofilms and is clinically effective in CRS treatment, while phonophoresis has also been utilized for antibiotic delivery through the skin...
  39. ncbi Management of chronic tendon injuries
    Marc A Childress
    Fort Belvoir Community Hospital, Fort Belvoir, VA 22060, USA
    Am Fam Physician 87:486-90. 2013
    ..Other modalities such as prolotherapy, topical nitroglycerin, iontophoresis, phonophoresis, therapeutic ultrasound, extracorporeal shock wave therapy, and low-level laser therapy have less evidence of ..
  40. doi Is phonophoresis effective in the treatment of chronic low back pain? A single-blind randomized controlled trial
    Dilek Durmus
    Department of Physical Medicine and Rehabilitation, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey
    Rheumatol Int 33:1737-44. 2013
    The aim of this trial is to investigate and compare the effects of phonophoresis (PP) and ultrasound (US) therapy on pain, disability, trunk muscle strength, walking performance, spinal mobility, quality of life (QOL), and depression in ..
  41. pmc The effect of sonophoresis on topical anesthesia: a pilot project
    Joseph L Packer
    Loma Linda University School of Dentistry, Loma Linda, California, USA
    Anesth Prog 60:37-41. 2013
    ..Subjects rated their discomfort after needle punctures utilizing the visual analog scale pain scoring system. There was no statistically significant difference in the pain perception using the DASD versus the control device...
  42. doi Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers
    Fei Yan
    Paul C Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
    J Control Release 166:246-55. 2013
    ..The significant increase in an antitumor efficacy of PLMC plus US suggests their potential use as a new targeted US chemotherapeutic approach to inhibit breast cancer growth...
  43. pmc Effect of therapeutic modalities on patients with patellofemoral pain syndrome: a systematic review
    David A Lake
    Department of Physical Therapy, Armstrong Atlantic State University, Savannah, Georgia
    Sports Health 3:182-9. 2011
    ..modalities have been recommended for the treatment of patients with PFPS-including cold, ultrasound, phonophoresis, iontophoresis, neuromuscular electrical stimulation, electrical stimulation for pain control, ..
  44. doi Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model
    D Takeuchi
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Japan
    Gene Ther 15:561-71. 2008
    ..A pharmacological approach including gene therapy to increase the HGF level in combination with anti-Abeta therapy might be a new therapeutic option for the treatment of AD...
  45. pmc The role of phonophoresis in dyshpagia due to cervical osteophytes
    Zeliha Unlu
    Department of Physical Medicine and Rehabilitation
    Int J Gen Med 1:11-3. 2009
    ..Physical therapy with its advantages may be an alternative method in the treatment, which was not reported previously...
  46. ncbi Temporomandibular joint disorders
    Jennifer J Buescher
    Clarkson Family Medicine Residency, Omaha, Nebraska 68131, USA
    Am Fam Physician 76:1477-82. 2007
    ..Physical therapy modalities (e.g., iontophoresis, phonophoresis), psychological therapies (e.g...
  47. doi Transcutaneous immunisation assisted by low-frequency ultrasound
    Afendi Dahlan
    Department of Pharmaceutics, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Int J Pharm 368:123-8. 2009
    ....
  48. doi Therapeutic modalities--an updated review for the hand surgeon
    Tristan L Hartzell
    Department of Orthopedic Surgery, Box 9569902, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6902, USA
    J Hand Surg Am 37:597-621. 2012
    ..on heat, massage, and cold therapy now uses electrical stimulators, ultrasound, biofeedback, iontophoresis, phonophoresis, mirror therapy, lasers, and a number of other modalities...
  49. doi Ultrasound-enhanced intrascleral delivery of protein
    Alex Chi Yeung Cheung
    Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
    Int J Pharm 401:16-24. 2010
    ..05W/cm(2)), suggest that cavitation is a possible mechanism for increasing the permeability of the sclera for diffusive transport...
  50. pmc Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends
    Baris E Polat
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Control Release 152:330-48. 2011
    The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥0...
  51. doi Comparison of ultrasound and ketoprofen phonophoresis in the treatment of carpal tunnel syndrome
    Necmettin Yildiz
    Pamukkale University Medical School, Department of Physical Medicine and Rehabilitation, Denizli, Turkey
    J Back Musculoskelet Rehabil 24:39-47. 2011
    The aim of this study was to compare the efficacy of ultrasound (US) and ketoprofen phonophoresis (PH) in the treatment of carpal tunnel syndrome (CTS).
  52. ncbi [Investigation in vivo of effect of ultrasound-mediated microbubble destruction on entrance of feridex into the aortal wall]
    Wen qing Gao
    Department of Radiology, Peking University Third Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 89:2797-801. 2009
    ..To explore feasibility for entrance of the contrast agent Sonovue and Feridex into the aortal wall...
  53. pmc Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation
    Linsey C Phillips
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    J Control Release 154:42-9. 2011
    ..The anti-proliferative effect was also localized within a 6mm wide zone by focusing the ultrasound beam...
  54. doi The anesthetic effect of lidocaine after varying times of phonophoresis
    Luke Donovan
    University of Virginia, Charlottesville, USA
    Am J Phys Med Rehabil 90:1056-63. 2011
    This study aimed to determine the anesthetic effect of 1-MHz phonophoresis using lidocaine on the anterior forearm following 5- and 10-min interventions.
  55. ncbi The efficacy of phonophoresis on electrophysiological studies of the patients with carpal tunnel syndrome
    Feray Soyupek
    Suleyman Demirel University, Isparta, Turkey
    Rheumatol Int 32:3235-42. 2012
    To investigate the efficacy of phonophoresis with nonsteroid anti-inflammatory drugs (P-NSAID) and corticosteroids (P-CS) in the treatment for carpal tunnel syndrome (CTS) and to compare the efficacy of phonophoresis with local CS ..
  56. doi Low frequency sonophoresis mediated transdermal and intradermal delivery of ketoprofen
    Anushree Herwadkar
    Department of Pharmaceutical Sciences, Mercer University, Atlanta, GA, United States
    Int J Pharm 423:289-96. 2012
    ..Low frequency sonophoresis with optimized ultrasound parameters can be effectively used to actively enhance transdermal and topical delivery of ketoprofen...
  57. ncbi Use of iontophoresis or phonophoresis for delivering onabotulinumtoxinA in the treatment of palmar hyperidrosis: a report on four cases
    Patrícia Cristina Andrade
    Herminio Ometto University Center, UNIARARAS, Araras, SP, Brazil
    An Bras Dermatol 86:1243-6. 2011
    ..Drugs such as onabotulinumtoxinA can be percutaneously delivered by phonophoresis or by iontophoresis and may be useful in the treatment of hyperhidrosis...
  58. doi The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro
    Yuanyuan Qiu
    Nanjing University, Jiangsu, PR China
    J Control Release 145:40-8. 2010
    ....
  59. ncbi A survey of therapeutic ultrasound use by physical therapists who are orthopaedic certified specialists
    Rita A Wong
    Department of Physical Therapy, Marymount University, 2807 N Glebe Rd, Arlington, VA 22207, USA
    Phys Ther 87:986-94. 2007
    ..This study examined the opinions of physical therapists with advanced competency in orthopedics about the use and perceived clinical importance of US in managing commonly encountered orthopedic impairments...
  60. ncbi Is there evidence that phonophoresis is more effective than ultrasound in treating pain associated with lateral epicondylitis?
    Terri Hoppenrath
    Department of Physical Therapy, Ithaca College, Ithaca, NY, USA
    Phys Ther 86:136-40. 2006
  61. ncbi Overcoming the stratum corneum: the modulation of skin penetration. A review
    H Trommer
    School of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics, Martin Luther University, Halle, Germany
    Skin Pharmacol Physiol 19:106-21. 2006
    ..to chemical methods, skin penetration of drugs can be improved by physical options such as iontophoresis and phonophoresis, as well as by combinations of both chemical and physical methods or by combinations of several physical ..
  62. doi Tolerance of low-frequency ultrasound sonophoresis: a double-blind randomized study on humans
    Annabel Maruani
    University François Rabelais Tours, Inserm U930 Tours, Service de Dermatologie, CHRU Tours, France
    Skin Res Technol 18:151-6. 2012
    ..Sonophoresis [low-frequency ultrasound (US)] has been used in animals and in vitro to investigate enhanced percutaneous absorption of drugs. No study focused on its clinical human tolerance has been published as yet...
  63. ncbi Ultrasound-enhanced transcorneal drug delivery
    Vesna Zderic
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Cornea 23:804-11. 2004
    ..Here, we report on our investigation of the mechanisms of ultrasound-enhanced drug delivery through the cornea using light and electron microscopy...
  64. doi Delivery of an angiogenic gene into ischemic muscle by novel bubble liposomes followed by ultrasound exposure
    Yoichi Negishi
    Department of Drug and Gene Delivery Systems School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, 192 0392, Japan
    Pharm Res 28:712-9. 2011
    ....
  65. doi Comparative study of the topical application of Aloe vera gel, therapeutic ultrasound and phonophoresis on the tissue repair in collagenase-induced rat tendinitis
    Antonio Luiz Martins Maia Filho
    Faculdade Integral Diferencial, FACID, Teresina, Piaui, Brazil
    Ultrasound Med Biol 36:1682-90. 2010
    The aim of our study was to compare topical use of Aloe vera gel, pulsed mode ultrasound (US) and Aloe vera phonophoresis on rat paw with collagenase-induced tendinitis...
  66. ncbi Therapy after injury to the hand
    Erik Dorf
    Department of Orthopaedic Surgery and Rehabilitation, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Am Acad Orthop Surg 18:464-73. 2010
    ..Modalities used to manage hand injuries include ultrasound, splinting, Fluidotherapy (Chattanooga Group, Chattanooga, TN), cryotherapy, various electrical modalities, phonophoresis, and iontophoresis.
  67. ncbi Low-frequency sonophoresis: pathologic and thermal effects in dogs
    A J Singer
    Department of Emergency Medicine, State University of New York, University Medical Center, Stony Brook, NY, USA
    Acad Emerg Med 5:35-40. 1998
    ..Prior to human trials, the authors studied the safety profile of low-frequency sonophoresis in dogs by evaluating microscopic and temperature changes in the skin after sonophoresis...
  68. ncbi [Deep Relief sonophoresis in degenerative changes of the knee joint]
    Nada Zjuzin
    Medicinski fakultet Sarajevo
    Med Arh 58:279-81. 2004
    ..Deep Relief has significant better effect for less pain and better improvement of functional capacity in comparison with ultrasound. Results of examination are statistic significant...
  69. ncbi Topical delivery of active principles: the field of dermatological research
    Massimiliano Nino
    Department of Systematic Pathology, Section of Dermatology, Naples, Italy
    Dermatol Online J 16:4. 2010
    ..Recent development of these methods are here reported and underline the importance and role of vehicles and other factors that determine effects of partition and diffusion, crucial to absorption...
  70. doi Comparison the efficacy of phonophoresis and ultrasound therapy in myofascial pain syndrome
    Saime Ay
    Department of Physical Medicine and Rehabilitation, Ufuk University School of Medicine, Ankara, Turkey
    Rheumatol Int 31:1203-8. 2011
    The aim of this study is to compare the effect of phonophoresis, ultrasound and placebo ultrasound therapies in the treatment of myofascial pain syndrome (MPS). This is a randomized, double-blind placebo controlled study...
  71. pmc Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin
    Jennifer E Seto
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Control Release 145:26-32. 2010
    ....
  72. ncbi Topical delivery of anti-sense oligonucleotides using low-frequency sonophoresis
    Ahmet Tezel
    Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Pharm Res 21:2219-25. 2004
    ..Herein, we assessed the potential of low-frequency ultrasound (20 kHz, 2.4 W/cm2) in delivering therapeutically significant quantities of anti-sense oligonucleotides into skin...
  73. pmc Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs
    Baris E Polat
    Massachusetts Institute of Technology, Department of Chemical Engineering, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Expert Opin Drug Deliv 7:1415-32. 2010
    ..In vivo studies have also established that LFS can act as a physical immunization adjuvant. LFS technology is already clinically available for use with topical anesthetics, with other technologies currently under investigation...
  74. ncbi Heel pain and phonophoresis
    Milind M Deshpande
    Vivekanand General Hospital, Hubli 580029
    J Indian Med Assoc 108:365. 2010
    A review of 25 cases of heel pain treated conservatively with phonophoresis, using the anti-inflammatory gel containing a combination of flufenamic acid, salicylic acid and mucopolysaccharide polysulphate is being reported here...
  75. ncbi Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery
    N Kanikkannan
    College of Pharmacy, Florida A and M University, Tallahassee, FL 32307, USA
    Curr Med Chem 7:593-608. 2000
    ..skin can be enhanced by physical methods such as iontophoresis (application of low level electric current) and phonophoresis (use of ultra sound energy) and by chemical penetration enhancers (CPE)...
  76. ncbi Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis
    H Tang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Pharm Sci 90:545-68. 2001
    ..The observed different roles of convection during LFS across HSS and FTS can be attributed to the different degrees of structural alteration that these two types of skin undergo during LFS...
  77. pmc An experimental and theoretical analysis of ultrasound-induced permeabilization of cell membranes
    Jagannathan Sundaram
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Biophys J 84:3087-101. 2003
    ..For each mechanism, the volume around the bubble within which bubbles induce reversible and irreversible membrane permeabilization was determined. Predictions of the model are consistent with experimental data...
  78. ncbi Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays
    Nadine Barrie Smith
    Department of Bioengineering and Graduate Program in Acoustics, College of Engineering, The Pennsylvania State University, University Park, PA 16802, USA
    Ultrasound Med Biol 29:1205-10. 2003
    ....
  79. ncbi The devil's in the details
    Peter C Panus
    Phys Ther 83:1128-9; author reply 1129. 2003
  80. ncbi Review of traditional and novel modalities that enhance the permeability of local therapeutics across the stratum corneum
    William W Ting
    Department of Dermatology, University of Iowa College of Medicine University of Iowa Health Care, Iowa City, Iowa 52242, USA
    Int J Dermatol 43:538-47. 2004
  81. ncbi Emerging technologies in transdermal therapeutics
    Victor M Meidan
    Laboratory for Drug Delivery, Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, 111 Lock Street, Newark, NJ 07103, USA
    Am J Ther 11:312-6. 2004
    ..This article sequentially reviews the basis of each of the new enhancement techniques and discusses how these emerging technologies will influence transdermal therapy in the coming years...
  82. ncbi [Usage of a chondroxide ointment in the treatment of patients with spinal osteochondrosis]
    O N Shepetova
    Zh Nevrol Psikhiatr Im S S Korsakova 104:64-5. 2004
  83. ncbi Experimental demonstration of the existence of highly permeable localized transport regions in low-frequency sonophoresis
    Joseph Kushner
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Pharm Sci 93:2733-45. 2004
    ..Finally, an analysis of the porosity/tortuosity ratio (epsilon/tau) values suggests that trans-cellular transdermal transport pathways are present within the highly permeable, and highly structurally perturbed, LTRs...
  84. doi Sonoporation of endothelial cells by vibrating targeted microbubbles
    Klazina Kooiman
    Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    J Control Release 154:35-41. 2011
    ..This study shows that targeted microbubbles can also be used to induce sonoporation, thus making it possible to combine molecular imaging and drug delivery...
  85. ncbi Drug delivery into the eye with the use of ultrasound
    Vesna Zderic
    Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th St, Seattle, WA 98105 USA
    J Ultrasound Med 23:1349-59. 2004
    ..To evaluate ultrasound enhancement of drug delivery through the cornea and the histologic appearance of the cornea up to 24 hours after treatment...
  86. ncbi Sonophoresis: a 50-year journey
    Samir Mitragotri
    Drug Discov Today 9:735-6. 2004
  87. ncbi Anti-inflammatory effects by transdermal application of triamcinolone acetonide gel using phonophoresis in rats
    Jae Heon Yang
    Department of Pharmacy, Woosuk University, Samrye 565 701, Korea
    Int J Pharm 302:39-46. 2005
    ..delivery of triamcinolone acetonide (TA), which is one of the synthetic glucocorticoids, in conjunction with phonophoresis, and to develop the carbopol gels of TA...
  88. doi Evaluation of histologic and electron microscopic changes after novel treatment using combined microdermabrasion and ultrasound-induced phonophoresis of human skin
    Jacob Dudelzak
    Skin Laser and Surgery Specialists of NY and NJ, New York, New York, USA
    J Cosmet Laser Ther 10:187-92. 2008
    ..b>Phonophoresis, a method of electrically assisted percutaneous delivery of macromolecules, relies on ultrasonic waves ..
  89. doi Modulation control over ultrasound-mediated gene delivery: evaluating the importance of standing waves
    Mariame A Hassan
    Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical, Sciences, University of Toyama, Sugitani 2630, Toyama 930 0194, Japan
    J Control Release 141:70-6. 2010
    ....
  90. ncbi Nitric oxide delivery by ultrasonic cracking: some limitations
    Michiel Postema
    Institute for Medical Engineering, Ruhr Universitat Bochum, Building IC, 6 146, D 44780 Bochum, Germany
    Ultrasonics 44:e109-13. 2006
    ..This indicates that ultrasonic cracking mostly occurs during the expansion phase...
  91. ncbi The physical therapy prescription
    Scott E Rand
    Conroe Medical Education Foundation, Conroe, TX, USA
    Am Fam Physician 76:1661-6. 2007
    ..A physical therapy prescription should include the diagnosis; type, frequency, and duration of the prescribed therapy; goals of therapy; and safety precautions...
  92. ncbi Effects of shear stress on endothelial cells: possible relevance for ultrasound applications
    E Vanbavel
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Prog Biophys Mol Biol 93:374-83. 2007
    ..Apart from safety concerns, such effects may provide a base for strategies aimed at targeted delivery of drugs...
  93. ncbi Evaluation of factors influencing the quality and efficacy of ultrasound and phonophoresis treatment
    Barbara Goraj-Szczypiorowska
    STOCER Prof M Weissa Rehabilitation Centre, Konstancin Jeziorna
    Ortop Traumatol Rehabil 9:449-58. 2007
    ..Despite a wide usage of phonophoresis in physical therapy cabinets, doubts persist as to the relevance and efficacy of this method...
  94. ncbi In vitro ultrasound-mediated leakage from phospholipid vesicles
    Mona Pong
    Chemical Engineering Department, Drexel University, Philadelphia, PA 19104, United States
    Ultrasonics 45:133-45. 2006
    ..The results of this work might be helpful to optimize acoustic field and membrane parameters for gene or drug delivery. The outcome of this work might also be useful in wound management...
  95. ncbi Rectangular cymbal arrays for improved ultrasonic transdermal insulin delivery
    Joseph Luis
    Graduate Program in Acoustics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Acoust Soc Am 122:2022-30. 2007
    ..However, using the rectangular cymbal array, the glucose decreased faster and to a level of -200.8+/-5.9 mgdl after 90 min. These results indicated the feasibility of the rectangular cymbal array as an improved device for drug delivery...
  96. ncbi Rehabilitation of synovitis in patients with haemophilia
    A Seuser
    Orthopaedic Department, Kaiser Karl Klinik, Special Hospital for Rehabilitation Medicine, Bonn, Germany
    Haemophilia 13:26-31. 2007
    ..with CO(2), and CP current after Bernhard should be used, if appropriate in combination with ultrasound and phonophoresis with Voltaren [Voltarol] Emulgel...
  97. ncbi Comparison of the therapeutic efficacy of phonophoresis and iontophoresis using dexamethasone sodium phosphate in the management of patients with knee osteoarthritis
    S R A Akinbo
    Department of Physiotherapy, College of Medicine University of Lagos
    Niger Postgrad Med J 14:190-4. 2007
    ..like, heat therapy, exercise therapy, electrical stimulation, therapeutic ultrasound, iontophoresis, and phonophoresis. This study was therefore designed to compare the effectiveness of 0...
  98. ncbi [Efficacy of ibuprofen (nurofen gel) ultraphonophoresis for pain relief in osteoarthrosis]
    N P Serikov
    Ter Arkh 79:79-81. 2007
    ..Thus, our study supports anesthetic efficacy of transcutaneous 5% gel nurofen in osteoarthrosis and a rise of this efficacy in combined use of ultrasound and this medicine in ultraphonophoresis...
  99. ncbi Iliotibial band friction syndrome--a systematic review
    Richard Ellis
    Health Rehabilitation Research Centre, Division of Rehabilitation and Occupation Studies, Faculty of Health and Environmental Sciences, AUT University, Auckland, New Zealand
    Man Ther 12:200-8. 2007
    ..examined included the use of non-steroidal anti-inflammatory drugs (NSAIDs), deep friction massage, phonophoresis versus immobilization and corticosteroid injection...
  100. ncbi Anesthetic effects of lidocaine hydrochloride gel using low frequency ultrasound of 0.5 MHz
    Tae Youl Kim
    Department of Physical Therapy, Dongshin University, Naju 520 714, Korea
    J Pharm Pharm Sci 10:1-8. 2007
    ..0.5 MHz ultrasound, which is a relatively higher frequency in the low-frequency range, can be applied in high intensity in continuous mode...
  101. ncbi Theme section: transdermal delivery of proteins
    Ajay K Banga
    Pharm Res 24:1357-9. 2007

Research Grants41

  1. Ultrasonic assessment of therapeutic response
    Katherine W Ferrara; Fiscal Year: 2010
    ..Further, we are developing methods to enhance therapeutic efficacy using ultrasound by enhancing the accumulation of drug within the tumor. ..
  2. Prostate Cancer Prevention by Pachymic Acid
    Lawrence Ng; Fiscal Year: 2006
    ..Through this study, it is anticipated that the potential of PA as a novel and safe agent for treatment or prevention against prostate cancer will be identified. ..
  3. CONTRAST ASSISTED ULTRASOUND IMAGING OF TUMORS
    Katherine Ferrara; Fiscal Year: 2006
    ..Since these hydrophobic drugs are now suspended in Cremophor for human use, a final aim is to develop acoustically-activated drug delivery vehicles that provide an alternative to the toxicity of Cremophor. ..
  4. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006
    ..3. Using an in vitro model, Epiderm, and in vivo mouse model, assess safety of skin exposure to low-frequency ultrasound. ..
  5. Engineering Approaches to Molecular Imaging Training
    Katherine Ferrara; Fiscal Year: 2007
    ..abstract_text> ..
  6. Ultrasound Imaging and Local Drug Delivery in Tumors
    Katherine Ferrara; Fiscal Year: 2007
    ..We will initially develop these drug delivery strategies for the unique environment of tumors, although the techniques should have broad application. ..
  7. Ultrasound Imaging and Local Drug Delivery in Tumors
    Katherine W Ferrara; Fiscal Year: 2010
    ..abstract_text> ..
  8. Ultrasonic assessment of therapeutic response
    Katherine Ferrara; Fiscal Year: 2009
    ..Further, we are developing methods to enhance therapeutic efficacy using ultrasound by enhancing the accumulation of drug within the tumor. ..
  9. Ultrasound Imaging and Local Drug Delivery in Tumors
    Katherine Ferrara; Fiscal Year: 2009
    ..In the renewal, we will develop infrastructure and protocols for successful image- guided drug delivery in models of head and neck and metastatic breast cancer. ..
  10. High Resolution Ultrasound cancer Imaging
    Katherine Ferrara; Fiscal Year: 2009
    ..We will test the performance and safety of the system for cancer imaging through in vitro and in vivo studies. ..
  11. High Resolution Ultrasound cancer Imaging
    Katherine Ferrara; Fiscal Year: 2007
    ..We will test the performance and safety of the system for cancer imaging through in vitro and in vivo studies. ..
  12. A Novel and Non-Invasive Method of Dermal Sampling
    Samir Mitragotri; Fiscal Year: 2003
    ..abstract_text> ..
  13. BRAIN THERAPY USING ULTRASOUND MEDIATED DRUG DELIVERY
    Lawrence Ng; Fiscal Year: 2001
    ....
  14. HIGH RESOLUTION BLOOD FLOW MAPPING IN OCULAR TISSUES
    Katherine Ferrara; Fiscal Year: 2003
    ..In conjunction with this study, mechanical damage to the vessel wall will be directly assessed through the use of fluorescent markers. ..
  15. CONTRAST ASSISTED ULTRASOUND IMAGING OF TUMORS
    Katherine Ferrara; Fiscal Year: 2003
    ..Since these hydrophobic drugs are now suspended in Cremophor for human use, a final aim is to develop acoustically-activated drug delivery vehicles that provide an alternative to the toxicity of Cremophor. ..
  16. AEROSOL BASED NANOPARTICAL DRUG DELIVERY SYSTEM--TB
    Lawrence Ng; Fiscal Year: 2002
    ..It is expected this multidisciplinary approach will provide significant advances in the treatment of TB and other airway diseases in which sustained drug release or targeting AMs would be advantageous. ..
  17. CONTRAST ASSISTED ULTRASOUND IMAGING OF TUMORS
    Katherine Ferrara; Fiscal Year: 2002
    ..These new methods will be evaluated in phantoms, through intravital microscopy in an ischemic rat model, and in a final comparative study of four mouse tumor cell lines and a benign fibroadenoma model. ..