oral administration

Summary

Summary: The giving of drugs, chemicals, or other substances by mouth.

Top Publications

  1. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
  2. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
  3. ncbi Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    Mark G Kris
    Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University, New York, NY 10021, USA
    JAMA 290:2149-58. 2003
  4. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
  5. ncbi The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    Matthew C Riddle
    Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes Care 26:3080-6. 2003
  6. doi Apixaban metabolism and pharmacokinetics after oral administration to humans
    Nirmala Raghavan
    Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543 4000, USA
    Drug Metab Dispos 37:74-81. 2009
  7. pmc The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    Joachim Stangier
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Br J Clin Pharmacol 64:292-303. 2007
  8. ncbi Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial
    S Bertil Olsson
    Department of Cardiology, University Hospital, Lund SE 221 85, Sweden
    Lancet 362:1691-8. 2003
  9. ncbi Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration
    Kin Tak Chan
    Department of Technology and Product Development, CK Life Sciences Int l, Holdings Inc, 2 Dai Fu Street, Tai Po Industrial Estate, Hong Kong SAR, China
    Cancer Lett 294:118-24. 2010
  10. ncbi Degradation of ginsenosides in humans after oral administration
    Mona Abdel Tawab
    Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt, Germany
    Drug Metab Dispos 31:1065-71. 2003

Detail Information

Publications314 found, 100 shown here

  1. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
    ....
  2. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
    ..There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation...
  3. ncbi Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    Mark G Kris
    Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University, New York, NY 10021, USA
    JAMA 290:2149-58. 2003
    ....
  4. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
    ..As a secondary observation, administration of GTCs also reduced lower urinary tract symptoms, suggesting that these compounds might also be of help for treating the symptoms of benign prostate hyperplasia...
  5. ncbi The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    Matthew C Riddle
    Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes Care 26:3080-6. 2003
    ..To compare the abilities and associated hypoglycemia risks of insulin glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7% HbA(1c)...
  6. doi Apixaban metabolism and pharmacokinetics after oral administration to humans
    Nirmala Raghavan
    Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543 4000, USA
    Drug Metab Dispos 37:74-81. 2009
    ..Thus, apixaban is an orally bioavailable inhibitor of factor Xa with elimination pathways that include metabolism and renal excretion...
  7. pmc The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    Joachim Stangier
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Br J Clin Pharmacol 64:292-303. 2007
    ..Two double-blind, randomized trials were undertaken to investigate the pharmacokinetics (PK), pharmacodynamics (PD) and tolerability of orally administered dabigatran etexilate in healthy male subjects...
  8. ncbi Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial
    S Bertil Olsson
    Department of Cardiology, University Hospital, Lund SE 221 85, Sweden
    Lancet 362:1691-8. 2003
    ..The oral direct thrombin inhibitor ximelagatran represents a potential alternative. We aimed to establish whether ximelagatran is non-inferior to warfarin, within a margin of 2% per year, for prevention of stroke and systemic embolism...
  9. ncbi Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration
    Kin Tak Chan
    Department of Technology and Product Development, CK Life Sciences Int l, Holdings Inc, 2 Dai Fu Street, Tai Po Industrial Estate, Hong Kong SAR, China
    Cancer Lett 294:118-24. 2010
    ..Moreover, in vivo study demonstrated that cucurbitacin B is effective against BEL-7402 xenograft when administrated orally...
  10. ncbi Degradation of ginsenosides in humans after oral administration
    Mona Abdel Tawab
    Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt, Germany
    Drug Metab Dispos 31:1065-71. 2003
    ..pathway of ginsenosides in the gastrointestinal tract of humans could be elucidated following the oral administration of ginseng...
  11. pmc Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels
    Marta Bolos
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, and CIBERNED, Madrid 28002, Spain
    J Biol Chem 285:17693-700. 2010
    ..Notably, oral administration of a GSK3 inhibitor to adult wild-type mice or to amyloid precursor protein/presenilin 1 mice modeling ..
  12. ncbi Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 313:423-7. 2004
    ..Studies performed in our laboratory during the past few years have revealed that oral administration of leucine to fasted rats enhances protein synthesis in association with increased phosphorylation of two ..
  13. doi Effects of maternal oral administration of morphine sulfate on developing rat fetal cerebrum: a morphometrical evaluation
    Seyed Homayoon Sadraie
    Applied Neuroscience Research Center, Neurobiology Research Division, Baqiyatallah University of Medical Sciences, Iran
    Brain Res 1245:36-40. 2008
    ..In conclusion, these results showed that morphine exposure during the second week of pregnancy could affect brain development in a way, which could lead to neurological and behavioral deficits in the postnatal animal...
  14. ncbi Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats
    Tong Lu
    Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing, 210009 Jiangsu Provience, PR China
    J Ethnopharmacol 110:412-8. 2007
    ..In the present study, pharmacokinetic differences of baicalin following oral administration of pure baicalin, Radix scutellariae extract, baicalin co-administrated with extract of the other three ..
  15. ncbi Bosentan therapy for pulmonary arterial hypertension
    Lewis J Rubin
    Division of Pulmonary and Critical Care Medicine, University of California at San Diego, La Jolla 92037 1330, USA
    N Engl J Med 346:896-903. 2002
    ..The present trial investigated the effect of bosentan on exercise capacity in a larger number of patients and compared two doses...
  16. doi A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan
    Ayumi Shibamura
    Department of Interdisciplinary Studies for Advanced Aged Society, Osaka City University Graduate School of Human Life Science, Sumiyoshi ku, Japan
    Mech Ageing Dev 130:652-5. 2009
    ..We used liposomes loaded with the hydrophilic fluorescent reagent uranin to test oral administration of water-soluble substances to C. elegans...
  17. doi Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice
    Hai Ying Yang
    College of Food Science and Nutritional Engineering, China Agricultural University, PO Box 303, Beijing 100083, China
    Nutr Res 29:281-9. 2009
    ....
  18. pmc Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration
    Elsa M Janle
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
    J Med Food 13:926-33. 2010
    ..Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders...
  19. doi Oral administration of lactobacilli from human intestinal tract protects mice against influenza virus infection
    M Kawase
    Technical Research Laboratory, Takanashi Milk Products Co, Ltd, Yokohama, Kanagawa, Japan
    Lett Appl Microbiol 51:6-10. 2010
    Our study was conducted to evaluate the potent protective effects of oral administration of probiotic Lactobacillus strains against influenza virus (Flu) infection in a mouse model.
  20. doi NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration
    Qian Bu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Nanotechnology 21:125105. 2010
    ..Moreover, the NMR-based metabolomic approach is a reliable and sensitive method to study the biochemical effects of nanomaterials...
  21. doi Daily oral administration of crocetin attenuates physical fatigue in human subjects
    Hiroshi Mizuma
    Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Nutr Res 29:145-50. 2009
    ..3-way crossover study, 14 Japanese healthy volunteers (7 men and 7 women) were randomized to oral administration of crocetin (15 mg), ascorbic acid (3,000 mg), or placebo for 8 days...
  22. ncbi Threshold mechanisms and site specificity in chromium(VI) carcinogenesis
    S De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 21:533-41. 2000
    ..All experimental and epidemiological data, and the underlying mechanisms, point to the occurrence of thresholds in chromium(VI) carcinogenesis...
  23. ncbi Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, United Kingdom
    N Engl J Med 357:1716-30. 2007
    ..Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited...
  24. doi Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
    Houfu Liu
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi Tech Park, Shanghai 201203, China
    Drug Metab Dispos 37:2290-8. 2009
    ..The aim of this study was to evaluate rat exposure to ginsenosides after oral administration of Sanqi extract and to identify the key factors affecting their absorption and disposition...
  25. ncbi Nicotine physical dependence and tolerance in the mouse following chronic oral administration
    Sheri D Grabus
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Campus, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 178:183-92. 2005
    ..Establishing such mouse models would eventually allow for an examination of the role of specific nicotinic receptor subtypes in mediating these processes (i.e. through the use of receptor knockouts)...
  26. doi In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration
    Eunhye Lee
    Cell Dynamics Research Center, Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    J Control Release 140:79-85. 2009
    ..docetaxel (DTX) prodrug comprising a conjugate between DTX and low molecular weight chitosan (LMWC) after oral administration. DTX was covalently attached to LMWC via a cleavable linker so as to be released from LMWC-DTX conjugate in ..
  27. pmc Mass vaccination with a two-dose oral cholera vaccine in a refugee camp
    D Legros
    Epicentre, Kampala, Uganda
    Bull World Health Organ 77:837-42. 1999
    ..However, the potential cost of the vaccine and the absence of quickly accessible stockpiles are major drawbacks for its large-scale use...
  28. ncbi Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension
    N Nagaya
    Department of Internal Medicine and Department of Pharmacy, National Cardiovascular Center, and Osaka Seamen's Insurance Hospital, Osaka, Japan
    Am J Respir Crit Care Med 163:887-91. 2001
    ..These results suggest that oral supplementation of L-arginine may have beneficial effects on hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension...
  29. ncbi Cu/Zn superoxide dismutase plays important role in immune response
    Moshe Marikovsky
    Department of Animal Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    J Immunol 170:2993-3001. 2003
    ..Conversely, oral administration of DSF lowered TNF-alpha serum level by 4-fold, lowered the delayed-type hypersensitivity response in a ..
  30. ncbi Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats
    Liang Xi
    Department of Pharmacology, China Pharmaceutical University, PO Box 46, 24 Tongjia Xiang, Nanjing 210009, PR China
    Phytomedicine 14:633-6. 2007
    This study investigated the pharmacokinetic properties of crocin following oral administration in rats. After a single oral dose, crocin was undetected while crocetin, a metabolite of crocin, was found in plasma at low concentrations...
  31. ncbi Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial
    Steven R Steinhubl
    Division of Cardiology, University of North Carolina, CB 7075, 338 Burnett Womack Bldg, Chapel Hill, NC 27599, USA
    JAMA 288:2411-20. 2002
    ..Also, although current clinical data suggest a benefit for beginning therapy with a clopidogrel loading dose prior to PCI, the practical application of this therapy has not been prospectively studied...
  32. doi Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats
    Hariom Yadav
    Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001 Haryana, India
    J Dairy Res 75:189-95. 2008
    ..This may empower antioxidant system of beta-cells and may slow down the reduction of insulin and elevation of blood glucose levels...
  33. pmc Exposure to oral bisphosphonates and risk of esophageal cancer
    Chris R Cardwell
    Centre for Public Health, Queen s University Belfast, Grosvenor Rd, Belfast BT12 6BJ, United Kingdom
    JAMA 304:657-63. 2010
    ..Esophagitis is a known adverse effect of bisphosphonate use, and recent reports suggest a link between bisphosphonate use and esophageal cancer, but this has not been robustly investigated...
  34. doi The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice
    Takashi Hashimoto
    Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai, Nada, Kobe, Hyogo 657 8501, Japan
    Br J Nutr 102:242-8. 2009
    ..In a single oral administration of 160 nmol fucoxanthin, fucoxanthinol and amarouciaxanthin A were detectable in all specimens tested in ..
  35. ncbi Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization
    Christophe P Frossard
    University Hospital of Geneva, Department of Pediatrics, Geneva, Switzerland
    J Allergy Clin Immunol 119:952-9. 2007
    ..Because tolerance to food is potentially modulated by IL-10, strategies to prevent food allergy should favor an increased delivery of IL-10 to the gut...
  36. ncbi Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides
    Feng Chen
    Mayo Clinic College of Medicine, Department of Pharmacology, Birdsall Bldg Rm 327, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
    FASEB J 20:1269-71. 2006
    ..The results indicate that ginseng itself, or purified ginsenosides, may have similarly useful effects in human disease...
  37. ncbi Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats
    Sang Chul Shin
    College of Pharmacy, Chonnam National University, Bukgu, Gwangju 500 757, Republic of Korea
    Int J Pharm 313:144-9. 2006
    ..If the results are further confirmed in the clinical trials, the tamoxifen dosage should be adjusted when tamoxifen is administered with quercetin or quercetin-containing dietary supplements in order to avoid potential drug interactions...
  38. ncbi ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    Stephen R Wedge
    Department of Cancer and Infection Research, AstraZeneca, Cheshire SK10 4TG, United Kingdom
    Cancer Res 62:4645-55. 2002
    ..Once-daily oral administration of ZD6474 to growing rats for 14 days produced a dose-dependent increase in the femoro-tibial epiphyseal ..
  39. ncbi Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
    Xavier Vitrac
    Laboratoire de Mycologie et Biotechnologie Végétale, EA 491, Universite de Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Life Sci 72:2219-33. 2003
    ..of this study were to investigate the absorption and tissue distribution of 14C-trans-resveratrol following oral administration to mice. Male Balb/c mice were given a single oral dose of 14C-trans-resveratrol and were sacrificed at 1...
  40. ncbi Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    Hagop Kantarjian
    M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 346:645-52. 2002
    ..Chronic myelogenous leukemia (CML) is caused by the BCR-ABL tyrosine kinase, the product of the Philadelphia chromosome. Imatinib mesylate, formerly STI571, is a selective inhibitor of this kinase...
  41. ncbi Egg oral immunotherapy in nonanaphylactic children with egg allergy
    Ariana D Buchanan
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 119:199-205. 2007
    ..There is no current active treatment for food allergy. Traditional injection immunotherapy has been proved unsafe, and thus there is a need for other forms of immunotherapy...
  42. doi Development of oral cladribine for the treatment of multiple sclerosis
    Hans Peter Hartung
    Department of Neurology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    J Neurol 257:163-70. 2010
    ..Preliminary results of the 96-week, double-blind, randomized, placebo-controlled, multicenter CLARITY (CLAdRIbine Tablets Treating MS OrallY) study are encouraging and provide the first complete phase III data on an oral DMD for MS...
  43. ncbi Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro
    Amala Soumyanath
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland OR 97239, USA
    J Pharm Pharmacol 57:1221-9. 2005
    ..Taken together, our findings indicate that components in Centella ethanolic extract may be useful for accelerating repair of damaged neurons...
  44. ncbi Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    C W Pouton
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Eur J Pharm Sci 11:S93-8. 2000
    Lipid' formulations for oral administration of drugs generally consist of a drug dissolved in a blend of two or more excipients, which may be triglyceride oils, partial glycerides, surfactants or co-surfactants...
  45. ncbi Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats
    H Takeuchi
    Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Japan
    J Control Release 86:235-42. 2003
    ..The effectiveness of the liposomal formulations in oral administration of calcitonin was evaluated by measuring the change in the blood calcium concentration of rats...
  46. ncbi Studies on absorption, distribution and metabolism of ginseng in humans after oral administration
    Jayeul Lee
    Department of Sasang Constitutional Medicine, Kyunghee Korean Medical Hospital, 1 Heogi dong, Dongdaemun Gu, Seoul 130 702, Republic of Korea
    J Ethnopharmacol 122:143-8. 2009
    ..This study was aimed to characterize the absorption, distribution and metabolism of ginseng in human subjects using pharmacokinetic experiments based on the metabolism by microflora obtained from the feces...
  47. pmc Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir
    S Bantia
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Antimicrob Agents Chemother 45:1162-7. 2001
    ..b>Oral administration of a dosage of 1 mg/kg of body weight/day of RWJ-270201 for 5 days (beginning 4 h preinfection) showed ..
  48. ncbi Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo
    G Mittal
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S A S Nagar, Punjab, India
    J Control Release 119:77-85. 2007
    ..Together, these results indicate that nanoparticulate formulations are ideal carriers for oral administration of estradiol having great potential to address the dose related issues of estradiol.
  49. ncbi Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration
    Betina Fiege
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Mol Genet Metab 81:45-51. 2004
    ..We measured BH(4) and total biopterin in dithioerythritol (DTE) pretreated plasma from four adults after oral administration of BH(4) (2, 10, and 20mg/kg body weight) using the differential iodine oxidation method...
  50. ncbi Oral administration of paramylon, a beta-1,3-D-glucan isolated from Euglena gracilis Z inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice
    Akihiko Sugiyama
    Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Japan
    J Vet Med Sci 72:755-63. 2010
    ..This study was designed to evaluate the suppressive effects of the oral administration of paramylon on the development of atopic dermatitis (AD)-like skin lesions induced by repeated application ..
  51. pmc Absolute bioavailability of imidafenacin after oral administration to healthy subjects
    Tomoya Ohno
    Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co, Ltd, Ibaraki, Japan
    Br J Clin Pharmacol 65:197-202. 2008
    ..6% and 36.1%, respectively. The pharmacokinetic profiles of imidafenacin after oral administration have been revealed. Imidafenacin is primarily metabolized to metabolites by CYP3A4 and UGT1A4.
  52. pmc Effects of cranberry juice on pharmacokinetics of beta-lactam antibiotics following oral administration
    Meng Li
    Department of Pharmacy, Health Science Complex H 361A, University of Washington, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 53:2725-32. 2009
    ..These results suggest that the use of cranberry juice at usual quantities as prophylaxis for UTI is not likely to alter the pharmacokinetics of these two oral antibiotics...
  53. ncbi Role of the GALT in scrapie agent neuroinvasion from the intestine
    Bridget R Glaysher
    Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh, United Kingdom
    J Immunol 178:3757-66. 2007
    ..In conclusion, these data demonstrate that following oral exposure TSE agent accumulation upon FDCs within lymphoid tissue within the intestine itself is critically required for efficient neuroinvasion...
  54. ncbi Impact of P-glycoprotein on clopidogrel absorption
    Dirk Taubert
    Institut fur Pharmakologie, Klinikum I für Innere Medizin, Cologne, and Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Clin Pharmacol Ther 80:486-501. 2006
    ..We tested the hypothesis that the intestinal efflux transporter P-glycoprotein (P-gp) limits the oral bioavailability of clopidogrel and that variance in the MDR1 gene encoding P-gp predicts absorption variability...
  55. pmc Expression of cholera toxin B-proinsulin fusion protein in lettuce and tobacco chloroplasts--oral administration protects against development of insulitis in non-obese diabetic mice
    Tracey Ruhlman
    University of Central Florida, Department of Molecular Biology and Microbiology, Biomolecular Science, Orlando, FL 32816 2364, USA
    Plant Biotechnol J 5:495-510. 2007
    ..This opens up the possibility for the low-cost production and delivery of human therapeutic proteins, and a strategy for the treatment of various other autoimmune diseases...
  56. ncbi Oral vaccination with salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague
    Xinghong Yang
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 178:1059-67. 2007
    ..pestis. These results show that a single Salmonella vaccine can deliver both F1- and V-Ags to effect both systemic and mucosal immune protection against Y. pestis...
  57. doi Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:2690-9. 2008
    ..b>Oral administration of L...
  58. ncbi A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats
    Ben J Boyd
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia
    Int J Pharm 340:52-60. 2007
    ..The results indicate that lipids that form liquid crystalline structures in excess water, may have application as an oral sustained release delivery system, providing they are not digested rapidly on administration...
  59. ncbi Metabolism and disposition of dasatinib after oral administration to humans
    Lisa J Christopher
    Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08540, USA
    Drug Metab Dispos 36:1357-64. 2008
    ....
  60. ncbi No effect of acute, single dose oral administration of Momordica charantia Linn., on glycemia, energy expenditure and appetite: a pilot study in non-diabetic overweight men
    Gursevak S Kasbia
    Behavioral and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Canada
    J Ethnopharmacol 126:127-33. 2009
    ..The objective of this study was to determine the acute effect of MC on postprandial glucose levels, energy expenditure/fuel mixture and appetite in overweight men...
  61. ncbi Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer
    S D Baker
    The Johns Hopkins Oncology Center, Baltimore, Maryland 21287, USA
    Clin Cancer Res 5:309-17. 1999
    ..The primary elimination pathway for TMZ is by pH-dependent degradation to MTIC and further degradation to AIC. Incomplete recovery of radioactivity may be explained by the incorporation of AIC into nucleic acids...
  62. pmc Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells
    Yaron Ilan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Immunol 30:167-77. 2010
    ..b>Oral administration of anti-CD3 has not been tested in humans, but suppresses autoimmunity in animal models...
  63. doi Oral administration of resveratrol in suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells
    Ya Ling Weng
    Department of Food Science, National Chiayi University, Chaiyi, Taiwan
    Mol Nutr Food Res 54:259-67. 2010
    ..of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells achieved by oral administration of resveratrol was assessed in three separate experiments...
  64. pmc Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium
    Akira Asari
    Hyaluronan Research Institute Inc, 4 5 9 Kichijojiminami cho, Musashino shi, Tokyo 180 0003, Japan
    J Biol Chem 285:24751-8. 2010
    ..Our results suggest that oral administration of HA900 modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-..
  65. ncbi Iron therapy in iron deficiency anemia in pregnancy: intravenous route versus oral route
    Françoise Bayoumeu
    Department of Anesthesia and Intensive Care, Maternity Hospital, Nancy, France
    Am J Obstet Gynecol 186:518-22. 2002
    ..The aim of this study was to compare intravenous iron sucrose versus oral iron sulfate in anemia at 6 months of pregnancy...
  66. ncbi Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Can
    W V Kern
    Sektion Infektiologie und Klinische Immunologie, Medizinische Universitätsklinik und Poliklinik, Ulm, Germany
    N Engl J Med 341:312-8. 1999
    ..If orally administered empirical therapy is as effective as intravenous therapy, it would offer advantages such as improved quality of life and lower cost...
  67. doi Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice
    Sergio Rodriguez-Cuenca
    Department of Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge CB2 0QQ, UK
    Free Radic Biol Med 48:161-72. 2010
    ..Therefore, MitoQ does not act as a pro-oxidant in vivo. These findings indicate that mitochondria-targeted antioxidants can be safely administered long-term to wild-type mice...
  68. doi The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis
    Sheila J Thornton
    Division of Pharmaceutics and Biopharmaceutics, The University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Expert Opin Drug Deliv 6:271-84. 2009
    ....
  69. ncbi Treatment of schizophrenia with long-acting injectable risperidone: a 12-month open-label trial of the first long-acting second-generation antipsychotic
    W Wolfgang Fleischhacker
    Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck, Austria
    J Clin Psychiatry 64:1250-7. 2003
    ..The long-term safety and efficacy of long-acting injectable risperidone, the first long-acting second-generation antipsychotic, were evaluated in stable patients with schizophrenia...
  70. ncbi Intestinal and immunological effects of daily oral administration of Lactobacillus salivarius CECT5713 to healthy adults
    Saleta Sierra
    Nutrition and Health Department, Puleva Biotech SA, Camino de Purchil 66, 18004 Granada, Spain
    Anaerobe 16:195-200. 2010
    ..27.3+/-6.4 pg/mL in control group, P<0.01). Thus, it can be concluded that daily administration of L. salivarius CECT5713 to healthy adults is safe and improve gut microbiota and different parameters related to immune response...
  71. ncbi Decrease in plasma concentrations of antiangiogenic agent TSU-68 ((Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid) during oral administration twice a day to rats
    Ryuichi Kitamura
    Pharmacokinetics Research Laboratory, Taiho Pharmaceutical Co, Ltd, 224 2, Ebisuno, Hiraishi, Kawauchicho, Tokushima 771 0194, Japan
    Drug Metab Dispos 35:1611-6. 2007
    ..Plasma clearance of TSU-68 intravenously administered 12 h after oral administration was 1...
  72. ncbi Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
    F I Kanaze
    Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Clin Nutr 61:472-7. 2007
    ..is available on the pharmacokinetics of the citrus flavanones hesperetin and naringenin after their oral administration to humans as pure aglycones...
  73. ncbi Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
    R J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Nutr Health Aging 13:189-97. 2009
    ..A treatment that increased the formation of neurites and dendritic spines might reverse this loss, thereby increasing the number of synapses and slowing the decline in cognition...
  74. ncbi Pharmacokinetics and pharmacodynamics of a new ACT formulation: Artesunate/Amodiaquine (TRIMALACT) following oral administration in African malaria patients
    V Sinou
    UMR MD3, Faculty of Pharmacy, University of Mediterranee, Institute of Tropical Medicine of the French Army Forces, Marseille, France
    Eur J Drug Metab Pharmacokinet 34:133-42. 2009
    ..48% carrying parasite with the CQ-resistant haplotype. This study shows that the AS/AQ combination TRIMALACT is safe and effective in the treatment of highly drug-resistant falciparum malaria...
  75. ncbi Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers
    Kazunori Hosoe
    Pharmacology and Toxicology Group, Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Takasago Shi, Hyogo, Japan
    Regul Toxicol Pharmacol 47:19-28. 2007
    ..studies with healthy subjects after administration of a single oral dose of 150 or 300 mg and after oral administration of 90, 150, or 300 mg for 4 weeks...
  76. ncbi Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies
    Colin W Pouton
    Department of Pharmaceutical Biology, Victorian College of Pharmacy, Monash University Parkville Campus, Victoria 3052, Australia
    Adv Drug Deliv Rev 60:625-37. 2008
    ..Finally we address the choice of lipid formulations in relation to the physicochemical properties of the drug...
  77. ncbi Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT)
    T Poynard
    Groupe Hospitalier, Faculté Pitie Salpêtrière, Universite Paris VI, URA CNRS 1484, France
    Lancet 352:1426-32. 1998
    ..The aim of this study was to compare the efficacy and safety of interferon alpha2b in combination with oral ribavirin with interferon alone, for treatment of chronic infection with hepatitis C virus (HCV)...
  78. ncbi Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats
    Zengshuan Ma
    Departments of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    Int J Pharm 293:271-80. 2005
    ..Confocal micrographs showed strong interaction between rat intestinal epithelium and chitosan nanoparticles 3h post-oral administration.
  79. ncbi In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate
    Wolfgang Wienen
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse, 88397 Biberach, Germany
    Thromb Haemost 98:155-62. 2007
    ..These data suggest that dabigatran is a potent, selective thrombin inhibitor and an orally active anticoagulant as the prodrug, dabigatran etexilate...
  80. ncbi Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    Laurent F Hennequin
    AstraZeneca, Centre de Recherches, Z I la Pompelle, B P 1050, Chemin de Vrilly, 51689 Reims, Cedex 2, France
    J Med Chem 45:1300-12. 2002
    ..b>Oral administration of representative compounds to mice (50 mg/kg) produced plasma levels between 0...
  81. ncbi Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis
    Sarah Perkins
    Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:535-40. 2002
    ..6 g of curcumin is required for efficacy in humans. A clear advantage of curcumin over nonsteroidal anti-inflammatory drugs is its ability to decrease intestinal bleeding linked to adenoma maturation...
  82. pmc Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates
    K E Habib
    Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 97:6079-84. 2000
    ..After oral administration, significant antalarmin concentrations were detected in the systemic circulation and the cerebrospinal ..
  83. ncbi Double-coated poly (butylcynanoacrylate) nanoparticulate delivery systems for brain targeting of dalargin via oral administration
    Debanjan Das
    College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    J Pharm Sci 94:1343-53. 2005
    The aim of this study is to evaluate oral administration of poly (butylcyanoacrylate) nanoparticulate delivery systems (PBCA-NDSs), double-coated with Tween 80 and poly (ethylene) glycol (PEG) 20000 for brain delivery of hexapeptide ..
  84. ncbi Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 17:15-20. 2006
    ..These decreases were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). This study demonstrates that beta-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo...
  85. ncbi Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis
    M Petersen
    Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
    Kidney Int 73:705-15. 2008
    ..Our study shows that GW788388 is a potent and selective inhibitor of TGF-beta signalling in vitro and renal fibrosis in vivo...
  86. ncbi Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs
    Shui Mei Khoo
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
    Pharm Res 20:1460-5. 2003
    ....
  87. ncbi Comparative effect of oral administration and topical application of alcoholic extract of Terminalia arjuna bark on incision and excision wounds in rats
    Madhura M Rane
    CU Shah College of Pharmacy, SNDT Women s University, Santacruz West, Mumbai, Maharashtra 400 049, India
    Fitoterapia 74:553-8. 2003
    ..The estimated increase in hydroxyproline content of the granulation tissue of the excision wounds indicated rapid collagen turnover thus, leading to rapid healing of the wounds...
  88. ncbi Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter
    K Yamanaka
    College of Pharmacy, Nihon University, Funabashi, Chiba, Japan
    Biol Pharm Bull 24:510-4. 2001
    ..We also discussed the involvement of a reactive oxygen species (ROS), e.g., the dimethylarsenic peroxy radical [(CH3)2AsOO.], produced during the metabolic processing of DMA, in skin and in multi-organ tumorigenesis...
  89. ncbi HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract
    Jinlan Zhang
    School of Pharmaceutical Sciences and Modern Research Center for Traditional Chinese Medicine, Peking University, Beijing 100083, People s Republic of China
    Biomed Chromatogr 19:15-8. 2005
    ..has been established and validated for determination of salvianolic acid B (SalB) in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract. Liquid-liquid extraction was adopted for the sample preparation...
  90. pmc Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:417-26. 2008
    ..We sought to determine clinical predictors to identify patients who are at low risk of recurrent venous thromboembolism who could safely discontinue oral anticoagulants...
  91. doi Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract
    Jeevan K Prasain
    Department of Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phytomedicine 16:233-43. 2009
    ..Using LC-MS/MS, (+)-catechin and (-)-epicatechin were identified in the brain conclusively. These data suggested that GSE catechins cross the blood brain barrier and may be responsible for the neuroprotective effects of GSE...
  92. ncbi Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    J Baselga
    Vall d Hebron University Hospital, Barcelona, Spain
    J Clin Oncol 20:4292-302. 2002
    ....
  93. ncbi Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin
    M K Pasanen
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Clin Pharmacol Ther 82:726-33. 2007
    ..521CC genotype than in those with the c.521TT genotype. These results indicate that, unexpectedly, SLCO1B1 polymorphism has a larger effect on the AUC of atorvastatin than on the more hydrophilic rosuvastatin...
  94. ncbi Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor
    Susanne Roehrig
    Bayer HealthCare AG, D 42096 Wuppertal, Germany
    J Med Chem 48:5900-8. 2005
    ..Compound 5 is currently under clinical development for the prevention and treatment of thromboembolic diseases...
  95. ncbi Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A
    M H El-Shabouri
    Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
    Int J Pharm 249:101-8. 2002
    ..The relative bioavailability of Cy-A from chitosan-nanoparticles was increased by about 73%, and by about 18% from gelatin nanoparticles, while it was decreased by about 36% from SGC-nanoparticles...
  96. ncbi Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria
    P Teja-Isavadharm
    Department of Immunology and Medicine, US Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 65:717-21. 2001
    ..13+/-0.52 hr, respectively (P > 0.5). Both drug metabolism and tissue protein binding could contribute to the differences between the antimalarial activity of artemisinin drugs in healthy volunteers and malaria infected patients...
  97. ncbi Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats
    T Shirasaka
    Institute for Pathogenic Biochemistry in Medicine, Taiho Pharmaceutical Co, Ltd, Saitama, Japan
    Cancer Res 53:4004-9. 1993
    ..These findings suggest that coadministration of oxonic acid suppresses the GI toxicity of 5-FU and its derivatives without affecting their antitumor activity and thus prolongs the life span of cancer-bearing rats...
  98. ncbi Oral cholera vaccines: use in clinical practice
    David R Hill
    National Travel Health Network and Centre, London, UK
    Lancet Infect Dis 6:361-73. 2006
    ..The vaccine can be expected to prevent 7% or less of cases of travellers' diarrhoea and should not be used for this purpose...
  99. ncbi Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus
    Julia B Zella
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Arch Biochem Biophys 417:77-80. 2003
    ..Our results indicate that vitamin D status is a determining factor of disease susceptibility and oral administration of 1,25(OH)(2)D(3) prevents diabetes onset in NOD mice through 200 days of age.
  100. ncbi A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats
    Takefumi Itoh
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Respir Crit Care Med 169:34-8. 2004
    ..These results suggest that combination therapy with oral sildenafil and beraprost attenuates the development of MCT-induced pulmonary hypertension compared with treatment with each drug alone...
  101. ncbi Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial
    Gerald Simonneau
    Service de Pneumologie, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    Ann Intern Med 149:521-30. 2008
    ..Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension...

Research Grants86

  1. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
    ..The PCL matrix is expected to protect the DNA- containing nanoparticles upon oral administration and allow the release to occur in the small and large intestine due to enzymatic degradation with lipases...
  2. IMPACT OF INTESTINAL DYSFUNCTION ON ANTIRETROVIRAL THERAPY IN INDIA
    Rita Isaac; Fiscal Year: 2009
    ..of initiation of HAART using the tests d-xylose and mannitol:lactulose excretion in the urine following oral administration of these sugars...
  3. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2010
    ..is tasked with development of preclinical formulations of these NCEs suitable for intravenous injection and oral administration to mice and dogs and for testing in vitro in cell cultures...
  4. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2011
    ..is tasked with development of preclinical formulations of these NCEs suitable for intravenous injection and oral administration to mice and dogs and for testing in vitro in cell cultures...
  5. DCTD Human Toxicology and Pharmacology
    LARRY ARTHUR; Fiscal Year: 2009
    ..is tasked with development of preclinical formulations of these NCEs suitable for intravenous injection and oral administration to mice and dogs and for testing in vitro in cell cultures...
  6. DCTD Human Toxicology and Pharmacology
    David Heimbrook; Fiscal Year: 2012
    ..is tasked with development of preclinical formulations of these NCEs suitable for intravenous injection and oral administration to mice and dogs and for testing in vitro in cell cultures...
  7. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor Amiji; Fiscal Year: 2009
    ..The PCL matrix is expected to protect the DNA- containing nanoparticles upon oral administration and allow the release to occur in the small and large intestine due to enzymatic degradation with lipases...
  8. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2012
    ..characterization of three top TZUs;each exhibits key attributes including in vivo efficacy following oral administration and outstanding microbiological potency...
  9. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..after randomization to either: (i) 2 weeks of effective CPAP treatment ("CPAP group") or (ii) 2 weeks of oral administration of a placebo tablet 30min before bedtime ("placebo group")...
  10. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2009
    ..after randomization to either: (i) 2 weeks of effective CPAP treatment ("CPAP group") or (ii) 2 weeks of oral administration of a placebo tablet 30min before bedtime ("placebo group")...
  11. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda Saif; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): We will explore oral administration of different passive heterologous antibodies (Abs), chicken egg yolk IgY and recombinant VHH fragments derived from llama heavy chain Abs as an alternative or ..
  12. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): We will explore oral administration of different passive heterologous antibodies (Abs), chicken egg yolk IgY and recombinant VHH fragments derived from llama heavy chain Abs as an alternative or ..
  13. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2010
    Almost fifty years ago, oral administration of Bis-dichloroacetyl-diamines (BDADs) such as WIN 18,446 was shown to safely, completely and reversibly inhibit spermatogenesis in men...
  14. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2010
    Almost fifty years ago, oral administration of Bis-dichloroacetyl-diamines (BDADs) such as WIN 18,446 was shown to safely, completely and reversibly inhibit spermatogenesis in men...
  15. BDADs for Male Contraception
    JOHN AMORY; Fiscal Year: 2009
    Almost fifty years ago, oral administration of Bis-dichloroacetyl-diamines (BDADs) such as WIN 18,446 was shown to safely, completely and reversibly inhibit spermatogenesis in men...
  16. Systemic AA Amyloidosis Inhibitors
    ALAN SNOW; Fiscal Year: 2009
    ..e. spleen, liver and kidney) by >50-60% following oral administration. PTI-19 and 51 represent new chemical entities and our established synthetic routes for the repeated ..
  17. BDADs for Male Contraception
    JOHN AMORY; Fiscal Year: 2009
    Almost fifty years ago, oral administration of Bis-dichloroacetyl-diamines (BDADs) such as WIN 18,446 was shown to safely, completely and reversibly inhibit spermatogenesis in men...
  18. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..e. spleen, liver and kidney) by >50-60% following oral administration. PTI-19 and 51 represent new chemical entities and our established synthetic routes for the repeated ..
  19. Stilbene's Contribution in Hemorrhagic Stroke
    SYLVAIN DORE; Fiscal Year: 2010
    ..We will investigate the effect of acute and chronic daily oral administration of resveratrol on brain injury volume, brain edema, and neurobehavioral outcome deficits at different time ..
  20. Therapeutic use of small-molecule HGF-mimetic for emphysema
    Bert Oehlen; Fiscal Year: 2009
    ..Importantly, we found that daily oral administration of BB3 can reverse established emphysema in the PPE-induced rat model...
  21. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Importantly, we found that daily oral administration of BB3 can reverse established emphysema in the PPE-induced rat model...
  22. DiosMemTM, a natural gamma-secretase inhibitor, opposes AD pathogenesis
    Jun Tan; Fiscal Year: 2009
    ..of this effect with reducing cerebral A[unreadable] pathology in a transgenic mouse model of AD via an oral administration. Flavonoid-diosmin (DiosMemTM) will be orally administered to Tg2576 mice before (prophylactic treatment ..
  23. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Chow; Fiscal Year: 2009
    ..Perillyl alcohol is not bioavailable after oral administration. It undergoes significant first-pass metabolism and is converted almost completely to two polar metabolites,..
  24. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..Perillyl alcohol is not bioavailable after oral administration. It undergoes significant first-pass metabolism and is converted almost completely to two polar metabolites,..
  25. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2009
    ..Intervention will consist of the individual and combined oral administration of one level of NAC and two levels of MTh flavonolignans or placebo for three months...
  26. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2010
    ..Intervention will consist of the individual and combined oral administration of one level of NAC and two levels of MTh flavonolignans or placebo for three months...
  27. Novel Treatment of menopausal hot flushes with an extradiol prodrug
    Istvan Merchenthaler; Fiscal Year: 2009
    ..involved in thermoregulation, (ii) establishing the optimal dose of Q-E2 following its subcutaneous and oral administration using two rat models of hot flush, (iii) provide evidence that the beneficial actions of Q-E2 are mediated ..
  28. Therapeutic Strategies for Environmental Lung Diseases
    James Bonner; Fiscal Year: 2007
    ..In the first aim we will determine whether the oral administration of bis(maltolato)oxovanadium(IV) (BMOV), a bioavailable form of vanadium that is used for diabetes therapy, ..
  29. CYCLIC ORAL ADMINISTRATION OF SCH66336 IN PATIENTS W/ ADVANCED CANCER
    A Adjei; Fiscal Year: 1999
    ..by cancer, 2) to characterize the single- and multiple-dose pharmacokinetics of SCH 66336 following oral administration, 3) to evaluate in a preliminary manner the anti-tumor activity of SCH 66336, 4) to evaluate in a ..
  30. Glutathione and Lung Fibrosis
    Rui Ming Liu; Fiscal Year: 2010
    ..Importantly, aerosol or oral administration of GSH or N-acetylcysteine (NAC), a precursor of GSH, attenuates lung fibrosis in experimental fibrosis ..
  31. Glutathione and Lung Fibrosis
    Rui Ming Liu; Fiscal Year: 2009
    ..Importantly, aerosol or oral administration of GSH or N-acetylcysteine (NAC), a precursor of GSH, attenuates lung fibrosis in experimental fibrosis ..
  32. MECHANISM OF ANTI-CARCINOGENIC EFFECT OF ANTIOXIDANTS
    YOGESH AWASTHI; Fiscal Year: 1980
    ..The effect of oral administration of ethoxyquin, BHA and BHT will be studied on lung adenoma produced in mice by administration of BP and DBA...
  33. IMMUNE MONITORING OF ANTIGEN SPECIFIC THERAPY
    David Hafler; Fiscal Year: 2000
    ..We will first examine whether parenteral or oral administration of insulin change the frequency of insulin or GAD autoantigen reactive T cells as measured by proliferation,..
  34. PHARMACOKINETICS & TARGETED DELIVERY OF ANTI AIDS DRUGS
    THEODORE BATES; Fiscal Year: 2002
    ..assess whether didanosine (ddI) undergoes presystemic (first-pass) gut wall and/or liver metabolism after oral administration; 2) to quantitatively assess whether allopurinol (an inhibitor of xanthine oxidase) inhibits the metabolism ..
  35. IMMUNE MONITORING OF ANTIGEN SPECIFIC THERAPY
    David Hafler; Fiscal Year: 1999
    ..We will first examine whether parenteral or oral administration of insulin change the frequency of insulin or GAD autoantigen reactive T cells as measured by proliferation,..
  36. Oral Testosterone for Male Hormonal Contraception
    John K Amory; Fiscal Year: 2011
    ..delivery include intramuscular injections, implants, or a daily transdermal patch or gel, since oral administration of testosterone (in contrast to other steroids) was thought to be impractical...
  37. M. AVIUM DISEASE--INHALED LIPOSOME ANTI-TB DRUG THERAPY
    Hans Schreier; Fiscal Year: 1990
    ..A major limiting factor for successful therapy of MAIC infections is the high incidence of toxicity from oral administration of clinically more efficacious drugs such as pyrazinamide, ethionamide, and cycloserine...
  38. RIDOGREL IN CLINICALLY STABLE, NON ACTIVE ULCERATIVE COLITIS PEDS PAT
    Jeffrey Blumer; Fiscal Year: 1999
    ..In man, ridogrel is completely absorbed after oral administration with negligible first-pass metabolism...
  39. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond Novak; Fiscal Year: 1990
    ..been reported to increase liver:body weight ratios in rats and to produce fatty degeneration of the liver; oral administration of PY to rats caused hepatic necrosis and the appearance of hepatic nodules...
  40. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond Novak; Fiscal Year: 1992
    ..been reported to increase liver:body weight ratios in rats and to produce fatty degeneration of the liver; oral administration of PY to rats caused hepatic necrosis and the appearance of hepatic nodules...
  41. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond Novak; Fiscal Year: 1993
    ..been reported to increase liver:body weight ratios in rats and to produce fatty degeneration of the liver; oral administration of PY to rats caused hepatic necrosis and the appearance of hepatic nodules...
  42. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond Novak; Fiscal Year: 1991
    ..been reported to increase liver:body weight ratios in rats and to produce fatty degeneration of the liver; oral administration of PY to rats caused hepatic necrosis and the appearance of hepatic nodules...
  43. Oral Vaccination for AIDS Prevention in Rhesus Macaques
    Anna Aldovini; Fiscal Year: 2009
    ..micro particle formulation of a DNA-MVA SIV vaccine stimulates broader mucosal and systemic responses after oral administration. 3. To evaluate which of the two above regimens provides the best protection from vaginal SIV challenge. 4...
  44. Oral Vaccination for AIDS Prevention in Rhesus Macaques
    Anna Aldovini; Fiscal Year: 2010
    ..micro particle formulation of a DNA-MVA SIV vaccine stimulates broader mucosal and systemic responses after oral administration. 3. To evaluate which of the two above regimens provides the best protection from vaginal SIV challenge. 4...
  45. Preventive Activity of Black Raspberries against Prostate Cancer
    Maarten C Bosland; Fiscal Year: 2010
    ..b>Oral administration of lyophilized berries reduced mammary carcinogenesis in a rat model, indicating that bioactive protective ..
  46. Islet Protection from Hypoxia Posttransplant
    Klearchos K Papas; Fiscal Year: 2010
    ..b>Oral administration, if effective, would provide a preferred, more practical and safer alternative to injections...
  47. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    ..The long-term objective is to develop agents for oral administration in clinical populations...
  48. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2001
    ..The long-term objective is to develop agents for oral administration in clinical populations...
  49. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    ..The long-term objective is to develop agents for oral administration in clinical populations...
  50. Oral BMS-275291 Metalloproteinase Inhibitor in Cancer
    Naiyer Rizvi; Fiscal Year: 2000
    ..Patients received once-daily oral administration of BMS-275291 in 4 week courses continuously until unmanageable toxicity or progressive disease...
  51. IMPACT OF INTESTINAL DYSFUNCTION ON ANTIRETROVIRAL THERAPY IN INDIA
    RITA CAROLINE ISAAC; Fiscal Year: 2010
    ..of initiation of HAART using the tests d-xylose and mannitol:lactulose excretion in the urine following oral administration of these sugars...
  52. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2006
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  53. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2007
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  54. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2005
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  55. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  56. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2004
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  57. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2003
    ..In comparison to tolerance induced by the i.v. or oral administration of soluble peptide, tolerance induced by Ag-SP was shown to be highly effective for prevention and ..
  58. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2004
    ..In comparison to tolerance induced by the i.v. or oral administration of soluble peptide, tolerance induced by Ag-SP was shown to be highly effective for prevention and ..
  59. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2002
    ..In comparison to tolerance induced by the i.v. or oral administration of soluble peptide, tolerance induced by Ag-SP was shown to be highly effective for prevention and ..
  60. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen Miller; Fiscal Year: 2001
    ..In comparison to tolerance induced by the i.v. or oral administration of soluble peptide, tolerance induced by Ag-SP was shown to be highly effective for prevention and ..
  61. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge P Malafa; Fiscal Year: 2010
    ..shows accumulation of bioactive concentrations of 4-tocotrienol in the pancreatic tissue of mice following oral administration. These findings combined with its superior efficacy and safety, make 4-tocotrienol a promising anticancer ..
  62. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge Malafa; Fiscal Year: 2009
    ..shows accumulation of bioactive concentrations of 4-tocotrienol in the pancreatic tissue of mice following oral administration. These findings combined with its superior efficacy and safety, make 4-tocotrienol a promising anticancer ..
  63. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2005
    ..It has now been realized that oral administration in USA trials was inappropriate and new Phase III trials will soon be undertaken...
  64. Novel Puerarin Analogs with Anti-Diabetic Activity
    NICHOLAS CAIRNS; Fiscal Year: 2007
    ..p. or oral administration. Puerarin is rapidly absorbed from the intestine without metabolism and appears to exert its hypoglycemic ..
  65. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2003
    ..It has now been realized that oral administration in USA trials was inappropriate and new Phase III trials will soon be undertaken...
  66. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..It has now been realized that oral administration in USA trials was inappropriate and new Phase III trials will soon be undertaken...
  67. Long-term non-fluctuating dopamine agonist delivery for Parkinson's disease
    SUNIL P contact SREEDHARAN; Fiscal Year: 2010
    ..and dyskinesias in PD may be caused by pulsatile stimulation of dopamine receptors such as occurs after oral administration of current DA therapies...
  68. DOXYCYCLINE EFFECT ON OSTEOARTHRITIS PROGRESSION
    Kenneth Brandt; Fiscal Year: 1999
    ..We have shown that prophylactic oral administration of doxycycline (doxy) markedly reduces the severity of cartilage damage in a canine model of OA; even when ..
  69. DOXYCYCLINE EFFECT ON OSTEOARTHRITIS PROGRESSION
    Kenneth Brandt; Fiscal Year: 2001
    ..We have shown that prophylactic oral administration of doxycycline (doxy) markedly reduces the severity of cartilage damage in a canine model of OA; even when ..
  70. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..Pharmacokinetic and toxicity studies of STAMP conducted in mice, rats, cats, and dogs following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules showed favorable pharmacokinetics...
  71. DOXYCYCLINE EFFECT ON OSTEOARTHRITIS PROGRESSION
    Kenneth Brandt; Fiscal Year: 2000
    ..We have shown that prophylactic oral administration of doxycycline (doxy) markedly reduces the severity of cartilage damage in a canine model of OA; even when ..
  72. DOXYCYCLINE EFFECT ON OSTEOARTHRITIS PROGRESSION
    Kenneth Brandt; Fiscal Year: 2003
    ..We have shown that prophylactic oral administration of doxycycline (doxy) markedly reduces the severity of cartilage damage in a canine model of OA; even when ..
  73. GC-C agonists for colitis-induced CRC
    Kunwar Shailubhai; Fiscal Year: 2009
    ..Furthermore, the oral administration of UG inhibited not only polyp formation but also their progression to intestinal tumors in Apc Min/+ mice...
  74. The Critical Role of Bile Salts:Gut Protection in Critical Illness
    Eric Strauch; Fiscal Year: 2009
    ..b>Oral administration of sodium taurocholate improves anastomotic healing after bile duct ligation...
  75. Development of Novel Therapies or Methamphetamine Abuse
    Linda Dwoskin; Fiscal Year: 2009
    ..evaluations to assess their drugability, as well as their ability to decrease methamphetamine SA following oral administration. Our goal by the end of the 2nd year of the Competitive Revision Application is to have identified a ..
  76. Glycosphingolipids as targets for male contraception
    Frances Platt; Fiscal Year: 2006
    ..Therefore, it is important to identify and investigate ways, by which male fertility can be regulated. Oral administration of the alkylated imino sugars N-butyldeoxynojirimycin (NB-DNJ) and N-butyldeoxygalactonojirimycin (NB-DGJ) ..
  77. STABILIZATION OF DRUG SUBSTANCES METASTABLE POLYMORPHS
    LEVON BOSTANIAN; Fiscal Year: 2000
    ..Formulation of such poorly water- soluble drugs in the metastable form for oral administration will enhance drug absorption and therapeutic effectiveness...
  78. Glycosphingolipids as targets for male contraception
    Frances Platt; Fiscal Year: 2004
    ..Therefore, it is important to identify and investigate ways, by which male fertility can be regulated. Oral administration of the alkylated imino sugars N-butyldeoxynojirimycin (NB-DNJ) and N-butyldeoxygalactonojirimycin (NB-DGJ) ..
  79. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2004
    ..It has now been realized that oral administration in USA trials was inappropriate and new Phase III trials will soon be undertaken...
  80. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    ..to logically extend our findings from the previous funded proposal to investigate the efficacy of the oral administration of tin mesoporphyrin (SnMP), other selected heme analogs, and non-porphyrin inhibitors of HO to the heme-..
  81. Evaluation of CYP24 as a Target for Enhancing Vitamin D
    Donald Trump; Fiscal Year: 2005
    ..on high exposure to calcitriol which may be limited by: [1] apparent "saturable absorption" following oral administration, which may depend on induction of mucosal and hepatic metabolism of calcitriol by CYP24, the enzyme most ..
  82. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..on high exposure to calcitriol which may be limited by: [1] apparent "saturable absorption" following oral administration, which may depend on induction of mucosal and hepatic metabolism of calcitriol by CYP24, the enzyme most ..
  83. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    ..to logically extend our findings from the previous funded proposal to investigate the efficacy of the oral administration of tin mesoporphyrin (SnMP), other selected heme analogs, and non-porphyrin inhibitors of HO to the heme-..
  84. Live Oral Listeria Vaccine Vector
    PAUL ORNDORFF; Fiscal Year: 2009
    ..Second, the mutant prospered in the mouse intestinal tract following oral administration, but could not be detected in the liver and spleen--features that speak to the applicability, practicality, ..