oral administration


Summary: The giving of drugs, chemicals, or other substances by mouth.

Top Publications

  1. ncbi Metabolism and kinetics of bisphenol a in humans at low doses following oral administration
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 15:1281-7. 2002
  2. ncbi Treatment of infectious mastitis during lactation: antibiotics versus oral administration of Lactobacilli isolated from breast milk
    Rebeca Arroyo
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Universidad Complutense de Madrid, Madrid, Spain
    Clin Infect Dis 50:1551-8. 2010
  3. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
  4. ncbi Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats
    Hariom Yadav
    Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001 Haryana, India
    J Dairy Res 75:189-95. 2008
  5. ncbi Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis
    Mohammad Ali
    International Vaccine Institute, Seoul, Korea
    Lancet 366:44-9. 2005
  6. pmc The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    Joachim Stangier
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Br J Clin Pharmacol 64:292-303. 2007
  7. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
  8. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
  9. ncbi Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor--after multiple dosing in healthy male subjects
    Dagmar Kubitza
    Institute of Clinical Pharmacology, Bayer HealthCare AG, 42096 Wuppertal, Germany
    Eur J Clin Pharmacol 61:873-80. 2005
  10. ncbi Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    C W Pouton
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Eur J Pharm Sci 11:S93-8. 2000

Detail Information

Publications354 found, 100 shown here

  1. ncbi Metabolism and kinetics of bisphenol a in humans at low doses following oral administration
    Wolfgang Völkel
    Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Chem Res Toxicol 15:1281-7. 2002
    ..Maximum blood levels of d(16)-bisphenol A glucuronide (approximately 800 nM) were measured 80 min after oral administration of d(16)-bisphenol A (5 mg)...
  2. ncbi Treatment of infectious mastitis during lactation: antibiotics versus oral administration of Lactobacilli isolated from breast milk
    Rebeca Arroyo
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Universidad Complutense de Madrid, Madrid, Spain
    Clin Infect Dis 50:1551-8. 2010
    ..The efficacy of oral administration of Lactobacillus fermentum CECT5716 or Lactobacillus salivarius CECT5713, two lactobacilli strains isolated ..
  3. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
  4. ncbi Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats
    Hariom Yadav
    Animal Biochemistry Division, National Dairy Research Institute, Karnal 132001 Haryana, India
    J Dairy Res 75:189-95. 2008
    ..This may empower antioxidant system of beta-cells and may slow down the reduction of insulin and elevation of blood glucose levels...
  5. ncbi Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis
    Mohammad Ali
    International Vaccine Institute, Seoul, Korea
    Lancet 366:44-9. 2005
    ..We reanalysed data from a field trial in Bangladesh to ascertain whether there is evidence of indirect protection from killed oral cholera vaccines...
  6. pmc The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    Joachim Stangier
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Br J Clin Pharmacol 64:292-303. 2007
    ..Two double-blind, randomized trials were undertaken to investigate the pharmacokinetics (PK), pharmacodynamics (PD) and tolerability of orally administered dabigatran etexilate in healthy male subjects...
  7. ncbi Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
    ..There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation...
  8. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
    ..As a secondary observation, administration of GTCs also reduced lower urinary tract symptoms, suggesting that these compounds might also be of help for treating the symptoms of benign prostate hyperplasia...
  9. ncbi Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor--after multiple dosing in healthy male subjects
    Dagmar Kubitza
    Institute of Clinical Pharmacology, Bayer HealthCare AG, 42096 Wuppertal, Germany
    Eur J Clin Pharmacol 61:873-80. 2005
  10. ncbi Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    C W Pouton
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Eur J Pharm Sci 11:S93-8. 2000
    Lipid' formulations for oral administration of drugs generally consist of a drug dissolved in a blend of two or more excipients, which may be triglyceride oils, partial glycerides, surfactants or co-surfactants...
  11. ncbi Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
    JianPing Weng
    Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Lancet 371:1753-60. 2008
  12. ncbi Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
    Christopher J H Porter
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Nat Rev Drug Discov 6:231-48. 2007
    ..a number of challenges to drug development - most notably, the issue of reduced systemic exposure after oral administration. However, it is increasingly apparent that formulations containing natural and/or synthetic lipids present ..
  13. ncbi Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration
    Zheng Cai
    Department of Pharmaceutics, West China School of Pharmacy, Sichuan University, Sichuan, PR China
    J Drug Target 16:178-84. 2008
    ..In this paper, the effect of borneol on the distribution of gastrodin to the brain in mice via oral administration was investigated...
  14. ncbi Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial
    S Bertil Olsson
    Department of Cardiology, University Hospital, Lund SE 221 85, Sweden
    Lancet 362:1691-8. 2003
    ..The oral direct thrombin inhibitor ximelagatran represents a potential alternative. We aimed to establish whether ximelagatran is non-inferior to warfarin, within a margin of 2% per year, for prevention of stroke and systemic embolism...
  15. ncbi Vitamin C pharmacokinetics: implications for oral and intravenous use
    Sebastian J Padayatty
    National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institut, and the Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1372, USA
    Ann Intern Med 140:533-7. 2004
    ..Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration...
  16. ncbi Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration
    Kin Tak Chan
    Department of Technology and Product Development, CK Life Sciences Int l, Holdings Inc, 2 Dai Fu Street, Tai Po Industrial Estate, Hong Kong SAR, China
    Cancer Lett 294:118-24. 2010
    ..Moreover, in vivo study demonstrated that cucurbitacin B is effective against BEL-7402 xenograft when administrated orally...
  17. pmc Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels
    Marta Bolos
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, and CIBERNED, Madrid 28002, Spain
    J Biol Chem 285:17693-700. 2010
    ..Notably, oral administration of a GSK3 inhibitor to adult wild-type mice or to amyloid precursor protein/presenilin 1 mice modeling ..
  18. ncbi Apixaban metabolism and pharmacokinetics after oral administration to humans
    Nirmala Raghavan
    Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, Princeton, New Jersey 08543 4000, USA
    Drug Metab Dispos 37:74-81. 2009
    ..Thus, apixaban is an orally bioavailable inhibitor of factor Xa with elimination pathways that include metabolism and renal excretion...
  19. ncbi The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    Matthew C Riddle
    Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes Care 26:3080-6. 2003
    ..To compare the abilities and associated hypoglycemia risks of insulin glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7% HbA(1c)...
  20. ncbi Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension
    N Nagaya
    Department of Internal Medicine and Department of Pharmacy, National Cardiovascular Center, and Osaka Seamen's Insurance Hospital, Osaka, Japan
    Am J Respir Crit Care Med 163:887-91. 2001
    ..These results suggest that oral supplementation of L-arginine may have beneficial effects on hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension...
  21. ncbi Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 313:423-7. 2004
    ..Studies performed in our laboratory during the past few years have revealed that oral administration of leucine to fasted rats enhances protein synthesis in association with increased phosphorylation of two ..
  22. ncbi Effects of maternal oral administration of morphine sulfate on developing rat fetal cerebrum: a morphometrical evaluation
    Seyed Homayoon Sadraie
    Applied Neuroscience Research Center, Neurobiology Research Division, Baqiyatallah University of Medical Sciences, Iran
    Brain Res 1245:36-40. 2008
    ..In conclusion, these results showed that morphine exposure during the second week of pregnancy could affect brain development in a way, which could lead to neurological and behavioral deficits in the postnatal animal...
  23. ncbi Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats
    Tong Lu
    Center of Drug Metabolism and Pharmacokinetic, China Pharmaceutical University, Nanjing, 210009 Jiangsu Provience, PR China
    J Ethnopharmacol 110:412-8. 2007
    ..In the present study, pharmacokinetic differences of baicalin following oral administration of pure baicalin, Radix scutellariae extract, baicalin co-administrated with extract of the other three ..
  24. ncbi The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful
    M Emília Juan
    Departament de Fisiologia Divisió IV, Facultat de Farmacia, Universitat de Barcelona, E 08028 Barcelona, Spain
    J Nutr 132:257-60. 2002
    ..These results support the view that repeated consumption of trans-resveratrol at 20 mg/(kg x d) does not adversely affect the variables tested in rats...
  25. ncbi Bosentan therapy for pulmonary arterial hypertension
    Lewis J Rubin
    Division of Pulmonary and Critical Care Medicine, University of California at San Diego, La Jolla 92037 1330, USA
    N Engl J Med 346:896-903. 2002
    ..The present trial investigated the effect of bosentan on exercise capacity in a larger number of patients and compared two doses...
  26. ncbi Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels
    Emiko Ito
    Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8673, Japan
    Toxicon 40:193-203. 2002
    ..Tumors were not observed in 11 mice treated at lower doses and in 19 control mice. Hyperplasia of epithelial cells was also observed in the stomach of six mice out of ten administered at 20 microg/kg...
  27. ncbi DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamide
    Isabelle Manière
    Agence Francaise de Securite Sanitaire des Aliments, Laboratoire d Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougeres Cedex, France
    Mutat Res 580:119-29. 2005
    ..Only weak and transient DNA damage was recorded in the liver, bone marrow and adrenals. The DNA-damaging effect of the compound observed in the blood leukocytes could be a simple biomarker of acrylamide exposure and genotoxicity...
  28. ncbi Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats
    Ming fei Zeng
    Separation Engineering of Chinese Traditional Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, PR China
    Fitoterapia 81:490-6. 2010
    ..The author had compared the pharmacokinetics of baicalin after oral administration of HLJDT decoction or pure baicalin in MCAO and sham-operated rats...
  29. ncbi Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics
    Chih Chieh Chen
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan
    Eur J Pharm Biopharm 74:474-82. 2010
    ..The in vivo real-time bioluminescence imaging indicated superior stability of the Myverol system over the SPC system in the gastric environment...
  30. ncbi Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults
    John S Markowitz
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425 0742, USA
    Clin Pharmacokinet 42:393-401. 2003
    ..To compare the rate and extent of absorption of DL-threo-methylphenidate (MPH) from two modified-release MPH formulations at their respective recommended starting doses in healthy adult volunteers...
  31. ncbi Circadian levels of serotonin in plasma and brain after oral administration of tryptophan in rats
    Soledad Sánchez Mateos
    Department of Physiology, Neuroimmunophysiology Research Group, Faculty of Science, University of Extremadura, Badajoz, Spain
    Basic Clin Pharmacol Toxicol 104:52-9. 2009
    ..In conclusion, oral administration of tryptophan during 7 days enhances serotonin levels over a 24-hr period, and produces an advance in the ..
  32. pmc Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration
    Elsa M Janle
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
    J Med Food 13:926-33. 2010
    ..Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders...
  33. ncbi Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice
    Hai Ying Yang
    College of Food Science and Nutritional Engineering, China Agricultural University, PO Box 303, Beijing 100083, China
    Nutr Res 29:281-9. 2009
  34. ncbi NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration
    Qian Bu
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, People s Republic of China
    Nanotechnology 21:125105. 2010
    ..Moreover, the NMR-based metabolomic approach is a reliable and sensitive method to study the biochemical effects of nanomaterials...
  35. ncbi Oral administration of lactobacilli from human intestinal tract protects mice against influenza virus infection
    M Kawase
    Technical Research Laboratory, Takanashi Milk Products Co, Ltd, Yokohama, Kanagawa, Japan
    Lett Appl Microbiol 51:6-10. 2010
    Our study was conducted to evaluate the potent protective effects of oral administration of probiotic Lactobacillus strains against influenza virus (Flu) infection in a mouse model.
  36. ncbi Daily oral administration of crocetin attenuates physical fatigue in human subjects
    Hiroshi Mizuma
    Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Nutr Res 29:145-50. 2009
    ..3-way crossover study, 14 Japanese healthy volunteers (7 men and 7 women) were randomized to oral administration of crocetin (15 mg), ascorbic acid (3,000 mg), or placebo for 8 days...
  37. ncbi Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    Mark G Kris
    Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University, New York, NY 10021, USA
    JAMA 290:2149-58. 2003
  38. ncbi Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies
    L A Hammond
    Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, TX 78829, USA
    J Clin Oncol 17:2604-13. 1999
  39. ncbi Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    Jochen Graff
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, University Hospital, Frankfurt Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Clin Pharmacol 47:1398-407. 2007
    ..Rivaroxaban strongly inhibits platelet-induced thrombin generation, after activation of either platelets or the coagulation pathway, even in the presence of minimal factor Xa inhibition in plasma...
  40. ncbi Oral administration of uracil-tegafur (UFT) inhibits liver micrometastasis of human colon cancer in an orthotopic nude mouse model and its early detection system
    Yutaka Takahashi
    Department of Surgical Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Surg Today 34:855-9. 2004
    ..To evaluate the effect of UFT (an oral antineoplastic drug combining uracil and tegafur) as an adjuvant chemotherapy...
  41. ncbi Secondary prevention of venous thromboembolism with the oral direct thrombin inhibitor ximelagatran
    Sam Schulman
    Coagulation Unit, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    N Engl J Med 349:1713-21. 2003
    ..For many patients with venous thromboembolism, secondary prevention with vitamin K antagonists is not extended beyond six months, since the risk of recurrence may be outweighed by the risk of major bleeding...
  42. ncbi Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections
    Eliézer K N'goran
    Laboratoire de Biologie Animale, Universite de Cocody, Abidjan, Cote d lvoire
    Am J Trop Med Hyg 68:24-32. 2003
    ..These findings enlarge the scope and potential of artemether and further contribute to discussions of its role as an additional tool for integrated schistosomiasis control...
  43. ncbi Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06
    Barry C Lembersky
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:2059-64. 2006
  44. ncbi Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions
    Masafumi Takeda
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 30:2495-503. 2010
    ..To determine whether the administration of an active form of vitamin D(3) (calcitriol) could prevent atherosclerosis through anti-inflammatory actions...
  45. ncbi Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer
    S D Baker
    The Johns Hopkins Oncology Center, Baltimore, Maryland 21287, USA
    Clin Cancer Res 5:309-17. 1999
    ..The primary elimination pathway for TMZ is by pH-dependent degradation to MTIC and further degradation to AIC. Incomplete recovery of radioactivity may be explained by the incorporation of AIC into nucleic acids...
  46. ncbi Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus
    Yan ling He
    Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts 02139 3584, USA
    Clin Pharmacokinet 46:577-88. 2007
    ..Vildagliptin is a dipeptidyl peptidase IV (DPP-4) inhibitor currently under development for the treatment of type 2 diabetes mellitus...
  47. ncbi Intestinal and immunological effects of daily oral administration of Lactobacillus salivarius CECT5713 to healthy adults
    Saleta Sierra
    Nutrition and Health Department, Puleva Biotech SA, Camino de Purchil 66, 18004 Granada, Spain
    Anaerobe 16:195-200. 2010
    ..27.3+/-6.4 pg/mL in control group, P<0.01). Thus, it can be concluded that daily administration of L. salivarius CECT5713 to healthy adults is safe and improve gut microbiota and different parameters related to immune response...
  48. ncbi Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody
    Hiroki Ishikawa
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 56:2103-9. 2007
    ..Protection by oral anti-CD3 was transforming growth factor-beta dependent. Our results demonstrate that oral anti-CD3 is effective in the model of STZ-induced diabetes and may be a useful form of therapy for type 1 diabetes in humans...
  49. ncbi Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
    F I Kanaze
    Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Clin Nutr 61:472-7. 2007
    ..is available on the pharmacokinetics of the citrus flavanones hesperetin and naringenin after their oral administration to humans as pure aglycones...
  50. ncbi Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer
    R A Sharma
    Oncology Department, University of Leicester, Leicester LE1 9HN, United Kingdom
    Clin Cancer Res 7:1894-900. 2001
    ..2 g daily, equivalent to 180 mg of curcumin; (b) curcumin has low oral bioavailability in humans and may undergo intestinal metabolism; and (c) larger clinical trials of Curcuma extract are merited...
  51. pmc Delay of insulin addition to oral combination therapy despite inadequate glycemic control: delay of insulin therapy
    Gregory A Nichols
    Kaiser Permanente Center for Health Research, Portland, OR 97227 1098, USA
    J Gen Intern Med 22:453-8. 2007
    ..Patients and providers may be reluctant to escalate to insulin therapy despite inadequate glycemic control...
  52. ncbi In vivo antitumor effects of chitosan-conjugated docetaxel after oral administration
    Eunhye Lee
    Cell Dynamics Research Center, Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    J Control Release 140:79-85. 2009
    ..docetaxel (DTX) prodrug comprising a conjugate between DTX and low molecular weight chitosan (LMWC) after oral administration. DTX was covalently attached to LMWC via a cleavable linker so as to be released from LMWC-DTX conjugate in ..
  53. ncbi Nicotine physical dependence and tolerance in the mouse following chronic oral administration
    Sheri D Grabus
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Campus, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 178:183-92. 2005
    ..Establishing such mouse models would eventually allow for an examination of the role of specific nicotinic receptor subtypes in mediating these processes (i.e. through the use of receptor knockouts)...
  54. pmc Mass vaccination with a two-dose oral cholera vaccine in a refugee camp
    D Legros
    Epicentre, Kampala, Uganda
    Bull World Health Organ 77:837-42. 1999
    ..However, the potential cost of the vaccine and the absence of quickly accessible stockpiles are major drawbacks for its large-scale use...
  55. ncbi Threshold mechanisms and site specificity in chromium(VI) carcinogenesis
    S De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 21:533-41. 2000
    ..All experimental and epidemiological data, and the underlying mechanisms, point to the occurrence of thresholds in chromium(VI) carcinogenesis...
  56. ncbi Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats
    Houfu Liu
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi Tech Park, Shanghai 201203, China
    Drug Metab Dispos 37:2290-8. 2009
    ..The aim of this study was to evaluate rat exposure to ginsenosides after oral administration of Sanqi extract and to identify the key factors affecting their absorption and disposition...
  57. ncbi Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, United Kingdom
    N Engl J Med 357:1716-30. 2007
    ..Adding insulin to oral therapy in type 2 diabetes mellitus is customary when glycemic control is suboptimal, though evidence supporting specific insulin regimens is limited...
  58. ncbi Cu/Zn superoxide dismutase plays important role in immune response
    Moshe Marikovsky
    Department of Animal Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    J Immunol 170:2993-3001. 2003
    ..Conversely, oral administration of DSF lowered TNF-alpha serum level by 4-fold, lowered the delayed-type hypersensitivity response in a ..
  59. ncbi Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial
    Steven R Steinhubl
    Division of Cardiology, University of North Carolina, CB 7075, 338 Burnett Womack Bldg, Chapel Hill, NC 27599, USA
    JAMA 288:2411-20. 2002
    ..Also, although current clinical data suggest a benefit for beginning therapy with a clopidogrel loading dose prior to PCI, the practical application of this therapy has not been prospectively studied...
  60. ncbi Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats
    Liang Xi
    Department of Pharmacology, China Pharmaceutical University, PO Box 46, 24 Tongjia Xiang, Nanjing 210009, PR China
    Phytomedicine 14:633-6. 2007
    This study investigated the pharmacokinetic properties of crocin following oral administration in rats. After a single oral dose, crocin was undetected while crocetin, a metabolite of crocin, was found in plasma at low concentrations...
  61. pmc Exposure to oral bisphosphonates and risk of esophageal cancer
    Chris R Cardwell
    Centre for Public Health, Queen s University Belfast, Grosvenor Rd, Belfast BT12 6BJ, United Kingdom
    JAMA 304:657-63. 2010
    ..Esophagitis is a known adverse effect of bisphosphonate use, and recent reports suggest a link between bisphosphonate use and esophageal cancer, but this has not been robustly investigated...
  62. ncbi Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization
    Christophe P Frossard
    University Hospital of Geneva, Department of Pediatrics, Geneva, Switzerland
    J Allergy Clin Immunol 119:952-9. 2007
    ..Because tolerance to food is potentially modulated by IL-10, strategies to prevent food allergy should favor an increased delivery of IL-10 to the gut...
  63. ncbi The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice
    Takashi Hashimoto
    Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai, Nada, Kobe, Hyogo 657 8501, Japan
    Br J Nutr 102:242-8. 2009
    ..In a single oral administration of 160 nmol fucoxanthin, fucoxanthinol and amarouciaxanthin A were detectable in all specimens tested in ..
  64. ncbi Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review
    M Malet-Martino
    Groupe de RMN Biomédicale, Laboratoire des IMRCP, Universite Paul Sabatier, Toulouse, France
    Oncologist 7:288-323. 2002
    ..The literature was analyzed until March 2002. This review is intended to be as exhaustive as possible since it was conceived as a work tool for readers wanting to go further...
  65. ncbi Antiproteinuric effect of oral paricalcitol in chronic kidney disease
    Rajiv Agarwal
    Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Kidney Int 68:2823-8. 2005
    ..While active vitamin D and its analogs have been shown to have renal protective effects in animals, these hormones have not been shown to reduce proteinuria in CKD patients...
  66. pmc Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:417-26. 2008
    ..We sought to determine clinical predictors to identify patients who are at low risk of recurrent venous thromboembolism who could safely discontinue oral anticoagulants...
  67. ncbi Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2275 Chemin Ste Foy, Ste Foy, Quebec G1V 4G5, Canada
    Am J Respir Crit Care Med 165:698-703. 2002
  68. ncbi Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomised controlled trial
    Lars Wallentin
    Uppsala Clinical Research Centre, University Hospital, Uppsala, Sweden
    Lancet 362:789-97. 2003
    ..We aimed to assess the effectiveness of ximelagatran and acetylsalicylic acid for prevention of death, non-fatal myocardial infarction, and severe recurrent ischaemia after a recent myocardial infarction...
  69. ncbi Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial
    S Jacob
    Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl and City Hospital, Baden Baden, Germany
    Free Radic Biol Med 27:309-14. 1999
    ..The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes...
  70. ncbi Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis
    M C Ramirez-Tortosa
    Department of Biochemistry and Molecular Biology, University of Granada, Faculty of Pharmacy, Campus de Cartuja 18071, Granada, Spain
    Atherosclerosis 147:371-8. 1999
    ..2-mg dosage. In conclusion, the use of this extract could be useful in the management of cardiovascular disease in which atherosclerosis is important...
  71. ncbi Reductions in levels of the Alzheimer's amyloid beta peptide after oral administration of ginsenosides
    Feng Chen
    Mayo Clinic College of Medicine, Department of Pharmacology, Birdsall Bldg Rm 327, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
    FASEB J 20:1269-71. 2006
    ..The results indicate that ginseng itself, or purified ginsenosides, may have similarly useful effects in human disease...
  72. ncbi Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats
    Sang Chul Shin
    College of Pharmacy, Chonnam National University, Bukgu, Gwangju 500 757, Republic of Korea
    Int J Pharm 313:144-9. 2006
    ..If the results are further confirmed in the clinical trials, the tamoxifen dosage should be adjusted when tamoxifen is administered with quercetin or quercetin-containing dietary supplements in order to avoid potential drug interactions...
  73. ncbi Egg oral immunotherapy in nonanaphylactic children with egg allergy
    Ariana D Buchanan
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 119:199-205. 2007
    ..There is no current active treatment for food allergy. Traditional injection immunotherapy has been proved unsafe, and thus there is a need for other forms of immunotherapy...
  74. ncbi Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro
    Amala Soumyanath
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland OR 97239, USA
    J Pharm Pharmacol 57:1221-9. 2005
    ..Taken together, our findings indicate that components in Centella ethanolic extract may be useful for accelerating repair of damaged neurons...
  75. ncbi Studies on absorption, distribution and metabolism of ginseng in humans after oral administration
    Jayeul Lee
    Department of Sasang Constitutional Medicine, Kyunghee Korean Medical Hospital, 1 Heogi dong, Dongdaemun Gu, Seoul 130 702, Republic of Korea
    J Ethnopharmacol 122:143-8. 2009
    ..This study was aimed to characterize the absorption, distribution and metabolism of ginseng in human subjects using pharmacokinetic experiments based on the metabolism by microflora obtained from the feces...
  76. ncbi ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    Stephen R Wedge
    Department of Cancer and Infection Research, AstraZeneca, Cheshire SK10 4TG, United Kingdom
    Cancer Res 62:4645-55. 2002
    ..Once-daily oral administration of ZD6474 to growing rats for 14 days produced a dose-dependent increase in the femoro-tibial epiphyseal ..
  77. ncbi Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
    Xavier Vitrac
    Laboratoire de Mycologie et Biotechnologie Végétale, EA 491, Universite de Bordeaux 2, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France
    Life Sci 72:2219-33. 2003
    ..of this study were to investigate the absorption and tissue distribution of 14C-trans-resveratrol following oral administration to mice. Male Balb/c mice were given a single oral dose of 14C-trans-resveratrol and were sacrificed at 1...
  78. ncbi Development of oral cladribine for the treatment of multiple sclerosis
    Hans Peter Hartung
    Department of Neurology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    J Neurol 257:163-70. 2010
    ..Preliminary results of the 96-week, double-blind, randomized, placebo-controlled, multicenter CLARITY (CLAdRIbine Tablets Treating MS OrallY) study are encouraging and provide the first complete phase III data on an oral DMD for MS...
  79. ncbi Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    Hagop Kantarjian
    M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 346:645-52. 2002
    ..Chronic myelogenous leukemia (CML) is caused by the BCR-ABL tyrosine kinase, the product of the Philadelphia chromosome. Imatinib mesylate, formerly STI571, is a selective inhibitor of this kinase...
  80. ncbi Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo
    G Mittal
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, S A S Nagar, Punjab, India
    J Control Release 119:77-85. 2007
    ..Together, these results indicate that nanoparticulate formulations are ideal carriers for oral administration of estradiol having great potential to address the dose related issues of estradiol.
  81. pmc Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir
    S Bantia
    BioCryst Pharmaceuticals, Inc, Birmingham, Alabama 35244, USA
    Antimicrob Agents Chemother 45:1162-7. 2001
    ..b>Oral administration of a dosage of 1 mg/kg of body weight/day of RWJ-270201 for 5 days (beginning 4 h preinfection) showed ..
  82. ncbi Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers
    Justin Cresser
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 299:R470-9. 2010
    ..However, an accumulation of diacylglycerol and ceramide, while associated with diet-induced insulin resistance, does not appear to be responsible for the agonist-induced reduction in insulin-stimulated glucose transport...
  83. ncbi A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan
    Ayumi Shibamura
    Department of Interdisciplinary Studies for Advanced Aged Society, Osaka City University Graduate School of Human Life Science, Sumiyoshi ku, Japan
    Mech Ageing Dev 130:652-5. 2009
    ..We used liposomes loaded with the hydrophilic fluorescent reagent uranin to test oral administration of water-soluble substances to C. elegans...
  84. pmc Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption
    Joseph M Custodio
    Department of Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, California 94143 0446, USA
    Adv Drug Deliv Rev 60:717-33. 2008
    ..That is, high fat meals and lipidic excipients would be expected to have little effect on F for Class 1 drugs; they would increase F of Class 2 drugs, while decreasing F for Class 3 drugs...
  85. pmc Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats
    Xiao Qing Peng
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Eur J Pharmacol 627:156-61. 2010
    ..We found that oral administration of GPI-5693 (15, 30, 60 mg/kg, p.o...
  86. ncbi Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen
    Eric D Lynch
    Sound Pharmaceuticals, Inc, Research and Development, 4010 Stone Way N, Suite 120, Seattle, WA 98103, USA
    Hear Res 201:81-9. 2005
    ..Further evaluation of the chemoprotective effects of ebselen and allopurinol on cisplatin side effects in the presence of tumor appears warranted...
  87. ncbi Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin
    I R Falconer
    Department of Clinical and Experimental Pharmacology, and CRC for Water Quality and Treatment, University of Adelaide Medical School, SA, Australia
    Environ Toxicol 16:192-5. 2001
    ..33-117) indicates a potential biological and public health significance requiring further investigation. Estimates are given of the size of experiment required to provide statistical proof of cylindrospermopsin carcinogenicity...
  88. ncbi Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice
    T Hasegawa
    Research Laboratories, Chlorella Industries Co, Ltd, Chikugo City, Fukuoka, Japan
    Int J Immunopharmacol 21:311-23. 1999
    ..We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by ..
  89. ncbi Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, PR China
    Clin Immunol 122:75-84. 2007
    ..These observations suggest that oral administration of CII (250-270) can suppress the cellular and humoral immune response in collagen-induced arthritis, and ..
  90. ncbi Therapeutic amoxicillin levels achieved with oral administration in term neonates
    Christele Gras-Le Guen
    Pediatric and Neonatal Critical Care Division, Department of Perinatology, Hopital Mere Enfant, Centre Hospitalier Universitaire, 38 Bd J Monnet, 44099 Nantes, Cedex, France
    Eur J Clin Pharmacol 63:657-62. 2007
    ..We investigated whether effective serum amoxicillin concentrations could be reached by switching to oral amoxicillin after 48 h of intravenous administration in full-term neonates with group B Streptococcus infection...
  91. ncbi Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats
    H Takeuchi
    Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Japan
    J Control Release 86:235-42. 2003
    ..The effectiveness of the liposomal formulations in oral administration of calcitonin was evaluated by measuring the change in the blood calcium concentration of rats...
  92. ncbi Degradation of ginsenosides in humans after oral administration
    Mona Abdel Tawab
    Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt, Germany
    Drug Metab Dispos 31:1065-71. 2003
    ..pathway of ginsenosides in the gastrointestinal tract of humans could be elucidated following the oral administration of ginseng...
  93. ncbi Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model
    Sarah Brem
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Cancer Chemother Pharmacol 60:643-50. 2007
  94. ncbi Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 224:209-13. 2007
    b>Oral administration of green tea or a caffeine solution, but not decaffeinated green tea, inhibits UVB-induced complete carcinogenesis in SKH-1 mice...
  95. ncbi Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration
    Betina Fiege
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland
    Mol Genet Metab 81:45-51. 2004
    ..We measured BH(4) and total biopterin in dithioerythritol (DTE) pretreated plasma from four adults after oral administration of BH(4) (2, 10, and 20mg/kg body weight) using the differential iodine oxidation method...
  96. pmc Absolute bioavailability of imidafenacin after oral administration to healthy subjects
    Tomoya Ohno
    Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co, Ltd, Ibaraki, Japan
    Br J Clin Pharmacol 65:197-202. 2008
    ..6% and 36.1%, respectively. The pharmacokinetic profiles of imidafenacin after oral administration have been revealed. Imidafenacin is primarily metabolized to metabolites by CYP3A4 and UGT1A4.
  97. pmc Effects of cranberry juice on pharmacokinetics of beta-lactam antibiotics following oral administration
    Meng Li
    Department of Pharmacy, Health Science Complex H 361A, University of Washington, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 53:2725-32. 2009
    ..These results suggest that the use of cranberry juice at usual quantities as prophylaxis for UTI is not likely to alter the pharmacokinetics of these two oral antibiotics...
  98. ncbi Oral administration of paramylon, a beta-1,3-D-glucan isolated from Euglena gracilis Z inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice
    Akihiko Sugiyama
    Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Japan
    J Vet Med Sci 72:755-63. 2010
    ..This study was designed to evaluate the suppressive effects of the oral administration of paramylon on the development of atopic dermatitis (AD)-like skin lesions induced by repeated application ..
  99. ncbi Role of the GALT in scrapie agent neuroinvasion from the intestine
    Bridget R Glaysher
    Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh, United Kingdom
    J Immunol 178:3757-66. 2007
    ..In conclusion, these data demonstrate that following oral exposure TSE agent accumulation upon FDCs within lymphoid tissue within the intestine itself is critically required for efficient neuroinvasion...
  100. ncbi No effect of acute, single dose oral administration of Momordica charantia Linn., on glycemia, energy expenditure and appetite: a pilot study in non-diabetic overweight men
    Gursevak S Kasbia
    Behavioral and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Canada
    J Ethnopharmacol 126:127-33. 2009
    ..The objective of this study was to determine the acute effect of MC on postprandial glucose levels, energy expenditure/fuel mixture and appetite in overweight men...
  101. ncbi Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:2690-9. 2008
    ..b>Oral administration of L...

Research Grants76

  1. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..Intervention will consist of the individual and combined oral administration of one level of NAC and two levels of MTh flavonolignans or placebo for three months...
  2. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..after randomization to either: (i) 2 weeks of effective CPAP treatment ("CPAP group") or (ii) 2 weeks of oral administration of a placebo tablet 30min before bedtime ("placebo group")...
  3. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..e. spleen, liver and kidney) by >50-60% following oral administration. PTI-19 and 51 represent new chemical entities and our established synthetic routes for the repeated ..
  4. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..For rodent studies, the PK of PWZ-029 will be measured in blood and brain following oral administration to assess its bioavailability...
  5. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..Aim 3 will determine the pharmacokinetics of transplatin following IV and oral administration. Aim 4 will determine the molecular basis of transplatin protection by gene microarray studies, focusing on ..
  6. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..Intervention will consist of the individual and combined oral administration of one level of NAC and two levels of MTh flavonolignans or placebo for three months...
  7. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..ratio, and/or fecal a-1 anti-trypsin) will identify infants with increased intestinal permeability;and 2) oral administration of LGG in VLBW infants with elevated intestinal permeability biomarkers will improve gut barrier function ..
  8. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..It has been shown that portal endotoxemia, induced by oral administration of dextrans specifically causes biliary damage in Cftr-KO mice, but not in their wild type littermates4...
  9. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..involved in thermoregulation, (ii) establishing the optimal dose of Q-E2 following its subcutaneous and oral administration using two rat models of hot flush, (iii) provide evidence that the beneficial actions of Q-E2 are mediated ..
  10. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..characterization of three top TZUs;each exhibits key attributes including in vivo efficacy following oral administration and outstanding microbiological potency...
  11. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Importantly, we found that daily oral administration of BB3 can reverse established emphysema in the PPE-induced rat model...
  12. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..We propose a clinical trial to test whether oral administration of CLA block production and uptake of lipids in tumors of patients with advanced cancers...
  13. Apple peel extract inhibits Cr(VI)-induced lung cancer
    Zhuo Zhang; Fiscal Year: 2013
    ..Our preliminary studies have shown that oral administration of apple peel extract decreased the number of nonmalignant and malignant skin tumors induced by 12-O-..
  14. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..are conducting a study with approximately 12 healthy volunteers to evaluate the metabolism of a single oral administration of tracer amounts of the RRR- (natural form) of vitamin E to learn more about how the human body utilizes ..
  15. H. pylori induced DNA Damage and Immune Dysregulation
    Keith T Wilson; Fiscal Year: 2013
    ..Inhibition of ODC with oral administration of a- difluoromethylornithine (DFMO) in mice restores L-Arg uptake, macrophage NO production, and cytokine ..
    Jacob McDonald; Fiscal Year: 2013
    ..In this contract, ADME properties of BMAA are investigated in rats and mice following oral administration to mimic relevant human exposure...
  17. The development of probiotic yeast as an inexpensive vaccine delivery platform
    TRACEY JANE LAMB; Fiscal Year: 2013
    ..b>Oral administration of genetically transformed S...
  18. Nanotheranostics for Early Colorectal Cancer Detection and Treatment
    Jeffrey S Souris; Fiscal Year: 2013
    ..We postulate that functionalization of these nanoplatforms for oral administration and polyp-targeted delivery of NSAIDs will provide a means for the prevention, detection, staging, and non-..
  19. GSK3beta, a mediator of ethanol neurotoxicity
    Xianglin Shi; Fiscal Year: 2013
    ..Pharmacologically relevant concentrations of C3G are achievable through oral administration or intravenous (iv) injection in animals, and no adverse effect is observed...
  20. Role of Oleylethanolamine in the Regulation of the HPT Axis
    Csaba Fekete; Fiscal Year: 2010
    ..is a recently described anorexigenic agent that has been shown to effectively reduce body weight after oral administration. Accordingly, OEA may be an attractive candidate for the treatment of obesity...
  21. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..the pharmacokinetics of the appearance of non-transferrin bound iron in the systemic circulation after oral administration of an iron supplement or other iron intervention; (2) to determine the effect of acute uncomplicated ..
  22. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..Perillyl alcohol is not bioavailable after oral administration. It undergoes significant first-pass metabolism and is converted almost completely to two polar metabolites,..
  23. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge P Malafa; Fiscal Year: 2012
    ..shows accumulation of bioactive concentrations of 4-tocotrienol in the pancreatic tissue of mice following oral administration. These findings combined with its superior efficacy and safety, make 4-tocotrienol a promising anticancer ..
    Jacob McDonald; Fiscal Year: 2012
    ..the contract is to investigate the metabolism and disposition of HMB in these strains following dermal and oral administration. BMAA is a chemical produced by some members of blue-green algae...
  25. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): We will explore oral administration of different passive heterologous antibodies (Abs), chicken egg yolk IgY and recombinant VHH fragments derived from llama heavy chain Abs as an alternative or ..
  26. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
    ..One of the leading treatments for T2D is oral administration of drugs in the thiazolidinedione compound group...
  27. A Novel Oral Combination Pediatric HIV and TB Vaccine
    Michelle H Larsen; Fiscal Year: 2012
    ..AIM 1 will test the hypothesis that oral administration of mc25226- SIVgag is safe and superior to parental vaccination in eliciting local mucosal immune responses ..
  28. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..Treatment of ALL requires a maintenance phase of approximately two years composed of oral administration of antimetabolites [6-Mercaptopurine (6MP) and methotrexate (MTX)] in order to achieve durable remissions...
  29. Oral Vaccination for AIDS Prevention in Rhesus Macaques
    Anna Aldovini; Fiscal Year: 2012
    ..micro particle formulation of a DNA-MVA SIV vaccine stimulates broader mucosal and systemic responses after oral administration. 3. To evaluate which of the two above regimens provides the best protection from vaginal SIV challenge. 4...
  30. A Diarylheptanoid Scaffold to Treat Taopathies
    Chad A Dickey; Fiscal Year: 2013
    ..We would seek to direct our program to identify agents that would be suitable for once-daily, oral administration for the treatment of tauopathies, to increase patient compliance and penetration...
  31. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2013
    Almost fifty years ago, oral administration of Bis-dichloroacetyl-diamines (BDADs) such as WIN 18,446 was shown to safely, completely and reversibly inhibit spermatogenesis in men...
    ANDREW K FOLICK; Fiscal Year: 2013
    ..b>Oral administration of OEA to C...
  33. Fruit exosome-like particles for therapeutic delivery of extracellular miRNAs
    Huang Ge Zhang; Fiscal Year: 2013
    ..them through an appropriate pore size filter significantly enhances EPNV translocation to the brain and oral administration of the EPNVs results in their migration to the liver...
  34. Pharmacokinetics and Metabolism of Oxidized Curcumin
    Claus Schneider; Fiscal Year: 2013
    ..we have detected the major oxidative metabolite of curcumin in plasma and intestinal mucosa after oral administration of curcumin to mice...
  35. The Mechanism of Uremia Induced Vascular Calcification
    Sharon M Moe; Fiscal Year: 2013
    ..We will determine if oral administration of cystamine, a broad TG inhibitor, can inhibit aorta vascular calcification in a naturally occurring rat ..
  36. Shiga Toxin & Ricin: Mechanisms of Ribotoxic Stress
    Cheleste M Thorpe; Fiscal Year: 2010
    ..Our work has revealed that oral administration of purified Shiga toxin 2 induces gut damage...
  37. Development of Novel Class of Anti-Inflammatory Drugs
    KEN CARTER; Fiscal Year: 2013
    ..gamma activation to select 3 lead derivatives/analogs for further development in vivo, and (3) compare the oral administration efficacy of 3 lead compounds against the parent compound 61610 and prednisolone, a steroid used by IBD ..
  38. Mechanistic basis of probiotic prevention of osteoporosis
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Most importantly, oral administration of a human derived probiotic, Lactobacillus reuteri ATCC PTA 6475, inhibits ovx induced intestinal changes, ..
  39. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..We will examine whether a) oral administration of LF prevents endotoxin transfer from the gut to the portal vein and decreases alcohol-induced hepatic ..
  40. Pharmacokinetic and pharmacodynamic optimization of soluble Abeta oligomer recept
    Susan M Catalano; Fiscal Year: 2012
    ..The requested funding will enable optimization of these promising molecules for oral administration, facilitating their advancement to IND-enabling preclinical studies and eventual clinical trials...
  41. Feasibility of grape seed extract for lung cancer chemoprevention
    Jenny T Mao; Fiscal Year: 2013
    ..We therefore hypothesize that oral administration of GSE is safe, can favorably modulate mechanisms associated with lung tumorigenesis, and may be useful for ..
  42. Study of gamma interferon agonists/mimetics
    Howard M Johnson; Fiscal Year: 2012
    ..Effect of SOCS-1 antagonist on protection. 2. Compare intraperitoneal versus oral administration of IFN mimetic peptides for their relative ability to protect mice against lethal vaccinia virus infection...
  43. Chemoprevention of Pancreatic Cancer by EGCG
    Rakesh K Srivastava; Fiscal Year: 2012
    ..EGCG induces cell cycle arrest and apoptosis in pancreatic cancer cells, (2) To determine the effects of oral administration of EGCG on growth and regression of human pancreatic cancer cells implanted in nude mice, and (3) To ..
  44. Interactions for Pesticides, mitochondria and genetics in Parkinson's disease.
    M Flint Beal; Fiscal Year: 2010
    ..Our preliminary data suggest that oral administration of pesticides in mice cause degeneration of nigrostriatal dopaminergic neurons, striatal loss of dopamine ..
  45. Oral paclitaxel solubilized and bioenhanced by food compound for cancer therapy
    Zhijun Liu; Fiscal Year: 2013
    ..Abraxane(r) conjugates PTX in albumin, which renders it unsuitable for oral administration, whereas PTX given in Taxol(r) form cannot be absorbed sufficiently for therapeutic bioavailability...
  46. Intervention models for thyroid proliferative disease using a bioactive food comp
    Raj K Tiwari; Fiscal Year: 2013
    ..III. Determine if oral administration of an absorption-enhanced formulation of DIM (Bioresponse DIM) achieves adequate thyroid tissue ..
  47. The Impact of Tolerance in the Newborn on Lentiviral Infection
    Joseph M McCune; Fiscal Year: 2013
    ..of the rhesus macaque) to induce tolerance by one of two proven routes (injection of antigen in utero and oral administration of antigen at birth) or by a combination thereof...
  48. Anthocyanins Derivatives for Drug Discovery in Aging Neurodegenerative Disorders
    David A Colby; Fiscal Year: 2012
    ..Previous studies have shown that only the glycosylated anthocyanins are present in the brain after oral administration;however, the sugar moiety is rapidly hydrolyzed during digestion to give the anthocyanin aglycone (called ..
  49. PD2024: A Peripherally Active TNFalpha inhibitor for the treatment of Obesity
    ..P2D, Inc. is developing small molecule TNF1 inhibitors that are amenable to oral administration to treat obesity and obesity-related insulin resistance...
  50. Effects of Acute and Chronic Alcohol on Brain Reward in Mice
    C J Malanga; Fiscal Year: 2013
    ..at early time points (15-30 minutes) and coincides with the peak blood alcohol concentration (BAC) after oral administration in both strains, supporting the idea that animals find the rising phase of the BAC curve more pleasurable ..
  51. Oral anti-TNF antibody for inflammatory bowel disease
    Daniel E Tracey; Fiscal Year: 2013
    ..We hypothesize that oral administration of AVX-470h (bovine antibody specific for human TNF) to human subjects will enable targeted distribution to ..
  52. CSF and the central chemical control of breathing.
    Eugene Edward Nattie; Fiscal Year: 2013
    ..g., an OX1R antagonist, and by oral administration of a novel antagonist to both the OX1R and OX2R...
  53. Aspirin, PPAR and EAE
    Kalipada Pahan; Fiscal Year: 2013
    ..Furthermore, oral administration of aspirin reduces clinical symptoms of EAE. This grant is anchored to these exciting findings...
  54. Functional significance of amyloid dynamics and deposition in the AD brain
    Gary E Landreth; Fiscal Year: 2013
    ..b>Oral administration of the RXR agonist, bexarotene, to a murine model of Alzheimer's disease resulted in enhanced ..
  55. A Potential New Drug for Depression
    EVE DAMIANO; Fiscal Year: 2009
    ..animal models of depression and anxiety, good plasma bioavailability and CNS penetration following oral administration, a strong safety profile, and high affinity and selectivity for the target receptor, The development of ..
  56. Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
    Charles C Y Shih; Fiscal Year: 2013
    ..An oral formulation of the selected compound (ASC J9 or analog) suitable for daily oral administration to humans (e.g., capsules, tablets, syrup) will be developed...
  57. Mitochondrial Proteome Dynamics in Heart Failure Assessed with Heavy Water
    Takhar Kasumov; Fiscal Year: 2013
    ..b>Oral administration of "heavy water" (2H2O;a safe, non-radioactive compound) results in rapid steady state labeling of body ..
  58. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..Our studies show that oral administration of bromelain, a proteinase mixture derived from pineapple, significantly decreases both the incidence of ..
  59. Development of Novel Tricyclic Pyrone Drugs for Treatment of Alzheimer Disease
    Xinmin Simon Xie; Fiscal Year: 2013
    ..on investigating the in vivo efficacy (neurobehavioral and neuropathological outcomes) of lead compounds by oral administration to the AD model APP/PS1 mice...
  60. Oral Agents to Stimulate Neutrophil Production
    SUSAN PARK PERRINE; Fiscal Year: 2010
    ..multi-lineage-hematopoietic cell lines, and have increased red blood cell counts in animal models, with oral administration. Recently, select Hemokines were also found to stimulate myelopoiesis in cytokine-dependent human and ..
  61. Live Oral Listeria Vaccine Vector
    PAUL EDWIN ORNDORFF; Fiscal Year: 2010
    ..Second, the mutant prospered in the mouse intestinal tract following oral administration, but could not be detected in the liver and spleen--features that speak to the applicability, practicality, ..
  62. GALT mediated protection against CNS demyelination: Role of commensal bacteria
    Lloyd H Kasper; Fiscal Year: 2012
    ..Prophylactic and therapeutic oral administration of a highly purified, structurally characterized preparation of the bacterial antigen, polysaccharide A (..
  63. DiosMemTM, a natural gamma-secretase inhibitor, opposes AD pathogenesis
    Jun Tan; Fiscal Year: 2009
    ..of this effect with reducing cerebral A[unreadable] pathology in a transgenic mouse model of AD via an oral administration. Flavonoid-diosmin (DiosMemTM) will be orally administered to Tg2576 mice before (prophylactic treatment ..
    David Hafler; Fiscal Year: 2000
    ..We will first examine whether parenteral or oral administration of insulin change the frequency of insulin or GAD autoantigen reactive T cells as measured by proliferation,..
    Hans Schreier; Fiscal Year: 1992
    ..A major limiting factor for successful therapy of MAIC infections is the high incidence of toxicity from oral administration of clinically more efficacious drugs such as pyrazinamide, ethionamide, and cycloserine...
  66. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    ..The long-term objective is to develop agents for oral administration in clinical populations...
  67. Islet Protection from Hypoxia Posttransplant
    Klearchos K Papas; Fiscal Year: 2010
    ..b>Oral administration, if effective, would provide a preferred, more practical and safer alternative to injections...
  68. Novel Puerarin Analogs with Anti-Diabetic Activity
    NICHOLAS CAIRNS; Fiscal Year: 2007
    ..p. or oral administration. Puerarin is rapidly absorbed from the intestine without metabolism and appears to exert its hypoglycemic ..
  69. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..It has now been realized that oral administration in USA trials was inappropriate and new Phase III trials will soon be undertaken...
  70. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..Pharmacokinetic and toxicity studies of STAMP conducted in mice, rats, cats, and dogs following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules showed favorable pharmacokinetics...
    Kenneth Brandt; Fiscal Year: 2003
    ..We have shown that prophylactic oral administration of doxycycline (doxy) markedly reduces the severity of cartilage damage in a canine model of OA; even when ..
  72. GC-C agonists for colitis-induced CRC
    Kunwar Shailubhai; Fiscal Year: 2009
    ..Furthermore, the oral administration of UG inhibited not only polyp formation but also their progression to intestinal tumors in Apc Min/+ mice...
  73. Development of Novel Therapies or Methamphetamine Abuse
    Linda Dwoskin; Fiscal Year: 2009
    ..evaluations to assess their drugability, as well as their ability to decrease methamphetamine SA following oral administration. Our goal by the end of the 2nd year of the Competitive Revision Application is to have identified a ..
  74. The Critical Role of Bile Salts:Gut Protection in Critical Illness
    Eric Strauch; Fiscal Year: 2009
    ..b>Oral administration of sodium taurocholate improves anastomotic healing after bile duct ligation...
  75. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..on high exposure to calcitriol which may be limited by: [1] apparent "saturable absorption" following oral administration, which may depend on induction of mucosal and hepatic metabolism of calcitriol by CYP24, the enzyme most ..
  76. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    ..to logically extend our findings from the previous funded proposal to investigate the efficacy of the oral administration of tin mesoporphyrin (SnMP), other selected heme analogs, and non-porphyrin inhibitors of HO to the heme-..