iontophoresis

Summary

Summary: Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.

Top Publications

  1. pmc Absorption of iontophoresis-driven 2% lidocaine with epinephrine in the tissues at 5 mm below the surface of the skin
    David O Draper
    Brigham Young University, Provo, UT, USA
    J Athl Train 46:277-81. 2011
  2. ncbi Muscle synergies encoded within the spinal cord: evidence from focal intraspinal NMDA iontophoresis in the frog
    P Saltiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurophysiol 85:605-19. 2001
  3. ncbi Iontophoresis in vivo demonstrates a key role for GABA(A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig
    F E LeBeau
    Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Neurosci 21:7303-12. 2001
  4. doi Non-invasive assessment of skin microvascular function in humans: an insight into methods
    Matthieu Roustit
    Clinical Pharmacology Unit, INSERM CIC03, Grenoble University Hospital, Grenoble, France
    Microcirculation 19:47-64. 2012
  5. doi C-fiber function assessed by the laser doppler imager flare technique and acetylcholine iontophoresis
    Alistair Q Green
    The Diabetes Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, UK
    Muscle Nerve 40:985-91. 2009
  6. doi Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
  7. ncbi Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis
    Jamie Turner
    University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
    Trends Cardiovasc Med 18:109-16. 2008
  8. ncbi Methodological issues in the assessment of skin microvascular endothelial function in humans
    Jean Luc Cracowski
    Department of Human Physiology, University of Oregon, OR 97403 1240, USA
    Trends Pharmacol Sci 27:503-8. 2006
  9. ncbi Iontophoresis - an approach for controlled drug delivery: a review
    Nitin Dixit
    Department of Pharmaceutics, Jamia Hamdard, Hamdard University, New Delhi 110062, India
    Curr Drug Deliv 4:1-10. 2007
  10. ncbi Permeability of the root canal wall and occlusion of dentinal tubules by Ag(NH3)2F: a comparison of combined use with pulsed Nd:YAG laser or iontophoresis
    K Yokoyama
    Department of Endodontics, Showa University School of Dentistry, Tokyo, Japan
    J Clin Laser Med Surg 18:9-14. 2000

Detail Information

Publications310 found, 100 shown here

  1. pmc Absorption of iontophoresis-driven 2% lidocaine with epinephrine in the tissues at 5 mm below the surface of the skin
    David O Draper
    Brigham Young University, Provo, UT, USA
    J Athl Train 46:277-81. 2011
    In a recent study, we were unable to measure lidocaine in the human calf at a 5-mm depth via iontophoresis. We surmised that this might be due to a lack of epinephrine in the compound...
  2. ncbi Muscle synergies encoded within the spinal cord: evidence from focal intraspinal NMDA iontophoresis in the frog
    P Saltiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurophysiol 85:605-19. 2001
    ..These findings are contrasted with previous approaches to the problem of synergies...
  3. ncbi Iontophoresis in vivo demonstrates a key role for GABA(A) and glycinergic inhibition in shaping frequency response areas in the inferior colliculus of guinea pig
    F E LeBeau
    Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Neurosci 21:7303-12. 2001
    ..We used the powerful combination of iontophoresis with detailed analysis of frequency response areas to test the hypothesis that GABAergic and glycinergic ..
  4. doi Non-invasive assessment of skin microvascular function in humans: an insight into methods
    Matthieu Roustit
    Clinical Pharmacology Unit, INSERM CIC03, Grenoble University Hospital, Grenoble, France
    Microcirculation 19:47-64. 2012
    ..Acetylcholine and sodium nitroprusside iontophoresis, despite their wide use as specific tests of endothelium-dependent and -independent function, respectively, ..
  5. doi C-fiber function assessed by the laser doppler imager flare technique and acetylcholine iontophoresis
    Alistair Q Green
    The Diabetes Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, UK
    Muscle Nerve 40:985-91. 2009
    Vasodilation induced by both acetylcholine iontophoresis (ACh Ionto) and the laser Doppler flare technique (LDIFT) can be used to measure small-fiber function. The aim of this study was to compare the neurogenic nature of these methods...
  6. doi Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
    ..The aim of this study was to determine whether the laser Doppler response of skin microcirculation to acetylcholine, reflects that of conduit artery assessed by brachial artery flow-mediated dilation (FMD)...
  7. ncbi Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis
    Jamie Turner
    University Division of Medicine and Therapeutics, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY Scotland, UK
    Trends Cardiovasc Med 18:109-16. 2008
    ..developed, including the use of laser Doppler flowmetry/imaging to measure cutaneous perfusion accompanied by iontophoresis of acetylcholine and sodium nitroprusside...
  8. ncbi Methodological issues in the assessment of skin microvascular endothelial function in humans
    Jean Luc Cracowski
    Department of Human Physiology, University of Oregon, OR 97403 1240, USA
    Trends Pharmacol Sci 27:503-8. 2006
    ..We review the advantages and limitations of postocclusive hyperemia, local thermal hyperemia, acetylcholine iontophoresis, flowmotion and association with microdialysis as tools with which to investigate skin microvascular ..
  9. ncbi Iontophoresis - an approach for controlled drug delivery: a review
    Nitin Dixit
    Department of Pharmaceutics, Jamia Hamdard, Hamdard University, New Delhi 110062, India
    Curr Drug Deliv 4:1-10. 2007
    ..Present review also provides an insight into reverse iontophoresis. Various parameters which affect the transdermal absorption of drugs through iontophoresis like drug ..
  10. ncbi Permeability of the root canal wall and occlusion of dentinal tubules by Ag(NH3)2F: a comparison of combined use with pulsed Nd:YAG laser or iontophoresis
    K Yokoyama
    Department of Endodontics, Showa University School of Dentistry, Tokyo, Japan
    J Clin Laser Med Surg 18:9-14. 2000
    ..hardness test to compare the penetration and hardness of silver resulting from use of either (i) pulsed Nd:YAG laser or (ii) iontophoresis, after root canal wall shaping using the standard method of coating with 38% Ag(NH3)2F solution.
  11. doi Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology
    Erik Tesselaar
    Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Microvasc Res 81:88-96. 2011
    ..Transdermal iontophoresis can be used to non-invasively introduce vasoactive drugs into the skin...
  12. ncbi Recurrent HSV-1 corneal epithelial lesions induced by timolol iontophoresis in latently infected rabbits
    Y Haruta
    LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112 2234
    Invest Ophthalmol Vis Sci 29:387-92. 1988
    ..virus type 1 (HSV-1) ocular shedding and recurrent corneal epithelial lesions were assessed following ocular iontophoresis of 0.01% timolol at 0...
  13. pmc Diabetic retinopathy is related to both endothelium-dependent and -independent responses of skin microvascular flow
    Thanh T Nguyen
    Centre for Eye Research Australia, Royal Victorian University of Melbourne, Melbourne, Australia
    Diabetes Care 34:1389-93. 2011
    ..We examined the relationship of DR to endothelium-dependent and endothelium-independent responses in skin microvascular flow...
  14. ncbi Treatment options for hyperhidrosis
    Hobart W Walling
    Am J Clin Dermatol 12:285-95. 2011
    ..Options include topical medications (most commonly aluminum chloride), iontophoresis, botulinum toxin injections, systemic medications (including glycopyrrolate and clonidine), and surgery (most ..
  15. ncbi 2% sodium fluoride-iontophoresis compared to a commercially available desensitizing agent
    Pankaj Singal
    D A V C Dental College, Periodontics, Yamuna Nagar, Haryana, India
    J Periodontol 76:351-7. 2005
    ..Thus, a cycle of sensitive teeth leading to reduced plaque control, more periodontal disease, and more recession may be established...
  16. ncbi Dose-dependent vasodilatory effects of acetylcholine and local warming on skin microcirculation
    Samuel Christen
    Division of Clinical Pathophysiology, University Hospital, Lausanne, Switzerland
    J Cardiovasc Pharmacol 44:659-64. 2004
    ..These techniques represent a unique means to investigate noninvasively the functional vasodilatory capacity of the skin microvasculature...
  17. ncbi Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis
    Deepankar Datta
    Centre for Rheumatic Diseases, Royal Infirmary, Glasgow, United Kingdom
    Atherosclerosis 192:391-5. 2007
    ..This was assessed non-invasively using laser Doppler imaging combined with iontophoresis of the vasodilators acetylcholine (ACh, endothelium dependent) and sodium nitroprusside (SNP, endothelium ..
  18. doi Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis
    Hitoshi Takahashi
    Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Arch Dermatol Res 300:291-5. 2008
    ..placebo-controlled study of ten healthy volunteers on histamine-induced flare and wheal response using an iontophoresis technique. The suppressive effect of olopatadine on the wheals induced by a 0...
  19. ncbi A protocol for iontophoresis of acetylcholine and sodium nitroprusside that minimises nonspecific vasodilatory effects
    Erik J Droog
    The Burns Unit, Department of Hand and Plastic Surgery, University Hospital, Linkoping, Sweden
    Microvasc Res 67:197-202. 2004
    b>Iontophoresis of vasoactive substances is a promising tool for studying pharmacological aspects of the (patho)physiology of the microvasculature. However, nonspecific microvascular responses are a common problem in most protocols used...
  20. pmc Impaired microvascular function in normal children: effects of adiposity and poor glucose handling
    Faisel Khan
    Vascular Diseases Research Unit, Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    J Physiol 551:705-11. 2003
    ..Skin microvascular responses, measured using laser Doppler imaging, to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), were negatively correlated with percentage body fat (r =..
  21. ncbi Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro
    Mariella Artusi
    Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze 27 A, 43100 Parma, Italy
    J Pharm Sci 93:2431-8. 2004
    ..The effect of the chemical enhancer lauric acid and the physical technique of iontophoresis was investigated. Permeation experiments were performed in vitro using rabbit ear skin as barrier...
  22. pmc Cathodal iontophoresis of treprostinil and iloprost induces a sustained increase in cutaneous flux in rats
    S Blaise
    INSERM ERI17, Grenoble Medical School, University Grenoble 1, Grenoble, France
    Br J Pharmacol 162:557-65. 2011
    ..The objective of this study was to test whether treprostinil, iloprost and epoprostenol can induce sustained vasodilatation in rats when delivered locally using cutaneous iontophoresis.
  23. doi A single-blinded comparative study between the use of glycolic acid 70% peel and the use of topical nanosome vitamin C iontophoresis in the treatment of melasma
    Rehab Mohamed Sobhi
    Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt
    J Cosmet Dermatol 11:65-71. 2012
    ..Melasma is a common pigmentary disorder. Despite the availability of a wide range of skin-lightening treatments, melasma of skin remains a therapeutic challenge...
  24. ncbi GABA, not glutamate, controls the activity of substantia nigra reticulata neurons in awake, unrestrained rats
    Francois Windels
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 24:6751-4. 2004
    ..To examine the role of these inputs, single-unit recording was coupled with iontophoresis of GLU and GABA in rats under two conditions: awake, unrestrained and under chloral hydrate anesthesia...
  25. ncbi Effect of lactic acid and iontophoresis on drug permeation across rabbit ear skin
    P Sebastiani
    Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100 Parma, Italy
    Int J Pharm 292:119-26. 2005
    ..We also explored the association of lactic acid and iontophoresis as a means of enhancing drug delivery...
  26. ncbi Current-induced vasodilation during water iontophoresis (5 min, 0.10 mA) is delayed from current onset and involves aspirin sensitive mechanisms
    S Durand
    Laboratory of Physiology, University Hospital, Angers, France
    J Vasc Res 39:59-71. 2002
    Study of the microcirculation by iontophoresis is potentially confounded by any non-specific effects of current application...
  27. doi Lidocaine transport through a cellophane membrane by alternating current iontophoresis with a duty cycle
    Shizuka Hayashi
    Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Bioelectrochemistry 74:315-22. 2009
    ..The higher voltages and duty cycles induced a pH change. The practical electrical conditions which are preferable for clinical application were 10 V with a 70% duty cycle or 20 V with a 60% duty cycle...
  28. ncbi Evaluation of a low-dose lidocaine iontophoresis system for topical anesthesia in adults and children: a randomized, controlled trial
    William T Zempsky
    University of Connecticut School of Medicine, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Clin Ther 26:1110-9. 2004
    ..A new low-dose lidocaine iontophoresis system (LDLIS) may provide topical anesthesia in 10 minutes at a lower dose than previous systems, thereby ..
  29. doi Effect and persistency of botulinum toxin iontophoresis in the treatment of palmar hyperhidrosis
    Sanaz Davarian
    Faculty of Rehabilitation, Shaheed Beheshti Medical University, Tehran, Iran
    Australas J Dermatol 49:75-9. 2008
    The purpose of this study was to investigate the efficacy and persistence of the hypohidrosis induced by iontophoresis of botulinum toxin type A in patients with palmar hyperhidrosis...
  30. ncbi Magnetic resonance imaging study of current and ion delivery into the eye during transscleral and transcorneal iontophoresis
    S Kevin Li
    Department of Pharmaceutics, Utah Center for Advanced Imaging Research Radiology, University of Utah, Salt Lake City, Utah 84112, USA
    Invest Ophthalmol Vis Sci 45:1224-31. 2004
    ..to determine by nuclear magnetic resonance imaging (MRI) the target sites of ion delivery in the eye during iontophoresis, compare transscleral and transcorneal ocular iontophoresis, and monitor the distribution of a probe ion in ..
  31. ncbi Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation
    S Kubli
    Division of Clinical Pathophysiology and Medical Teaching, University Hospital, Lausanne, Switzerland
    Clin Pharmacol Ther 69:238-44. 2001
    ..and 3 hours after drug administration, the forearm skin blood flow response to acetylcholine applied by iontophoresis was determined with the use of a laser Doppler scanner imaging system...
  32. pmc Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans
    S Durand
    Laboratory of Vascular Investigations, University Hospital, 49033 Angers Cedex, France
    J Physiol 561:811-9. 2004
    The participation of prostaglandins (PGs) in the cutaneous vasodilatation to acetylcholine (ACh) applied via iontophoresis is under debate...
  33. pmc Simultaneous, noninvasive, and transdermal extraction of urea and homocysteine by reverse iontophoresis
    Congo Tak Shing Ching
    Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou, Taiwan
    Int J Nanomedicine 6:417-23. 2011
    ..This in vitro study aimed to determine whether homocysteine is extractable transdermally and noninvasively, and whether homocysteine and urea can be extracted simultaneously by reverse iontophoresis.
  34. ncbi Effects of iontophoresis current magnitude and duration on dexamethasone deposition and localized drug retention
    Carter R Anderson
    Birch Point Medical Inc, Oakdale, Minn 55128, USA
    Phys Ther 83:161-70. 2003
    b>Iontophoresis is a process that uses bipolar electric fields to propel molecules across intact skin and into underlying tissue. The purpose of this study was to describe and experimentally examine an iontophoresis drug delivery model.
  35. doi Transdermal absorption of memantin--effect of chemical enhancers, iontophoresis, and role of enhancer lipophilicity
    S Del Rio-Sancho
    Instituto de Ciencias Biomedicas, Universidad CEU Cardenal Herrera, C Del Pozo S N 46115, Alfara del Patriarca Valencia, Spain
    Eur J Pharm Biopharm 82:164-70. 2012
    ..b>Iontophoresis exhibited the greatest ability to enhance the flux of drug with respect to the control; nevertheless, the ..
  36. ncbi Effect of iontophoresis and permeation enhancers on the permeation of an acyclovir gel
    Subhash S Vaghani
    Smt R B Patel Mahila, Atkot, Gujarat, India
    Curr Drug Deliv 7:329-33. 2010
    The purpose of the present study was to explore the combined effect of chemical enhancers and iontophoresis on the in vitro permeation of acyclovir gel across porcine skin...
  37. ncbi Corneal nerves contain intra-axonal HSV-1 after virus reactivation by epinephrine iontophoresis
    L Rivera
    Lions Eye Research Laboratories, Louisiana State University Medical Center School of Medicine, New Orleans
    Curr Eye Res 7:1001-8. 1988
    ..0 x 10(6) PFU/ml) in each eye. Beginning on postinfection day 82, ocular iontophoresis (0.8 mAmps for 8 min) of 0.01% epinephrine was done once a day for 3 consecutive days to induce reactivation...
  38. doi Evaluation of dexamethasone phosphate delivered by ocular iontophoresis for treating noninfectious anterior uveitis
    Amy E Cohen
    Eyegate Pharmaceuticals, Inc, Waltham, Massachusetts 02453, USA
    Ophthalmology 119:66-73. 2012
    Determine safe, effective, iontophoretic dose(s) of EGP-437 (dexamethasone phosphate formulated for iontophoresis) in patients with noninfectious anterior uveitis; evaluate systemic drug exposures.
  39. ncbi Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging
    Ivan Cordovil
    National Institute of Cardiology INC, Rio de Janeiro, Brazil
    Microvasc Res 83:376-9. 2012
    ....
  40. ncbi Acute, local effects of iontophoresed insulin and C-peptide on cutaneous microvascular function in Type 1 diabetes mellitus
    C Delaney
    International Diabetes Institute, 250 Kooyong Road, Caulfield, Victoria 3162, Australia
    Diabet Med 21:428-33. 2004
    ..There are no published data available examining physiological effects of C-peptide delivered in this way...
  41. ncbi Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation
    J Y Fang
    Pharmaceutical Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Br J Dermatol 151:132-40. 2004
    ..However, the permeability of hydrophilic ALA across the skin is very low...
  42. ncbi Lithium monitoring by reverse iontophoresis in vivo
    Benoît Leboulanger
    School of Pharmacy and Department of Psychiatry, University of Geneva, Geneva, Switzerland
    Clin Chem 50:2091-100. 2004
    We investigated reverse transdermal iontophoresis as an alternative, noninvasive method for lithium monitoring in vivo...
  43. ncbi Botulinum toxin type A by iontophoresis for primary palmar hyperhidrosis
    Gina M Kavanagh
    J Am Acad Dermatol 55:S115-7. 2006
  44. ncbi Topical delivery of active principles: the field of dermatological research
    Massimiliano Nino
    Department of Systematic Pathology, Section of Dermatology, Naples, Italy
    Dermatol Online J 16:4. 2010
    ..The main physical techniques that increase cutaneous penetration of substances are: iontophoresis (that increases the penetration of ionized substances), electroporation (that electrically induces penetration ..
  45. ncbi Possible therapeutic use of vasodilator iontophoresis
    Andrea K Murray
    Department of Physics and Astronomy, Laser Photonics Group, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    Microvasc Res 69:89-94. 2005
    ..The current treatment of choice for scleroderma-related critical digital ischaemia and/or ulceration is intravenous prostanoid therapy, necessitating hospitalisation. However, iloprost is often poorly tolerated and may be ineffective...
  46. doi Laser Doppler assessment of dermal circulatory changes in people with coronary artery disease
    Sharad C Agarwal
    Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, UK
    Microvasc Res 84:55-9. 2012
    ..We studied and compared microcirculatory changes in response to acetylcholine iontophoresis (ACh), local heating of the skin and reactive hyperaemia in patients with coronary artery disease (CAD).
  47. ncbi A mechanism of the high frequency AC iontophoresis
    T Shibaji
    Department of Dental Anesthesiology, Tokyo Medical and Dental University, Tokyo, Japan
    J Control Release 73:37-47. 2001
    The efficiency and the voltage dependence of the AC iontophoresis were studied in vitro...
  48. pmc Improved techniques for examining rapid dopamine signaling with iontophoresis
    Natalie Rios Herr
    The University of North Carolina at Chapel Hill, Department of Chemistry, CB 3290, Chapel Hill, NC 27599 3290, USA
    Front Biosci (Elite Ed) 5:249-57. 2013
    ..The drugs are ejected by iontophoresis in which an electrical current forces the movement of molecules by a combination of electrical migration and ..
  49. ncbi Iontophoresis: a non-invasive ocular drug delivery
    Esther Eljarrat-Binstock
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Control Release 110:479-89. 2006
    b>Iontophoresis as a non-invasive technique for ocular drug delivery has been investigated for many years...
  50. ncbi Vasodilator iontophoresis a possible new therapy for digital ischaemia in systemic sclerosis?
    A K Murray
    Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
    Rheumatology (Oxford) 47:76-9. 2008
    This study investigated whether whole finger vasodilator iontophoresis increases digital blood flow in patients with systemic sclerosis (SSc): If so, this might indicate a novel approach to therapy.
  51. doi Noninvasive and efficient transdermal delivery of CpG-oligodeoxynucleotide for cancer immunotherapy
    Kaoru Kigasawa
    Graduate School of Life Science, Hokkaido University, Kita 12 Nishi 6, Kita ku, Sapporo City, Hokkaido 060 0812 Japan
    J Control Release 150:256-65. 2011
    ..previously demonstrated that small interfering RNA (siRNA) was efficiently delivered into rat epidermis by iontophoresis. In this report, we investigate the effect of transdermal iontophoretic delivery of CpG-ODN on the induction ..
  52. pmc Non-invasive and transdermal measurement of blood uric acid level in human by electroporation and reverse iontophoresis
    Chih Kuei Lee
    Hopkins Health Management Center, Puli Christian Hospital, Nantou, Taiwan, Republic of China
    Int J Nanomedicine 5:991-7. 2010
    The aim of this study was to find out the optimum combination of electroporation (EP) and reverse iontophoresis (RI) on noninvasive and transdermal determination of blood uric acid level in humans...
  53. pmc Oral sildenafil increases skin hyperaemia induced by iontophoresis of sodium nitroprusside in healthy volunteers
    S Blaise
    Inserm CIC3, Grenoble Clinical Research Center, Grenoble University Hospital, Grenoble, France
    Br J Pharmacol 160:1128-34. 2010
    ..we tested whether sildenafil, alone or combined with local sodium nitroprusside (SNP) delivered through skin iontophoresis, increased forearm cutaneous blood conductance in healthy volunteers, and to assess how well this combination ..
  54. doi Comparative reproducibility of dermal microvascular blood flow changes in response to acetylcholine iontophoresis, hyperthermia and reactive hyperaemia
    Sharad C Agarwal
    Departments of Cardiology, Freeman Hospital, Newcastle upon Tyne NE77DN, UK
    Physiol Meas 31:1-11. 2010
    ..Various studies have used microvascular changes in response to these stimuli, especially ACh iontophoresis and local heating, as a surrogate marker of endothelial function...
  55. ncbi Pentazocine transport by square-wave AC iontophoresis with an adjusted duty cycle
    Saori Ogami
    Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8549, Japan
    J Med Dent Sci 55:15-27. 2008
    So far, pentazocine iontophoresis has never been studied, although pentazocine is widely used in pain management...
  56. doi Reproducibility of cutaneous microvascular function assessment using laser Doppler flowmetry and acetylcholine iontophoresis
    K A Brocx
    School of Psychology, Murdoch University, Perth, W A, Australia
    Skin Pharmacol Physiol 22:313-21. 2009
    To investigate the reproducibility of direct and axon-reflex vasodilator responses to increasing doses of acetylcholine administered transcutaneously by iontophoresis.
  57. ncbi Transdermal delivery of interferon alpha-2B using microporation and iontophoresis in hairless rats
    Advait V Badkar
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
    Pharm Res 24:1389-95. 2007
    To demonstrate transdermal delivery of interferon alpha-2b (IFNalpha2b) in hairless rats through aqueous microchannels (micropores) created in the skin and enhanced by iontophoresis.
  58. ncbi Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo
    Valentine Wascotte
    Unite de Pharmacie Galenique, Universite Catholique de Louvain, avenue E Mounier, UCL 7320, 1200, Brussels, Belgium
    Pharm Res 24:1897-901. 2007
    To demonstrate the "skin reservoir" of urea by confocal Raman microspectroscopy in vivo and to evaluate its impact on the non-invasive monitoring of the analyte by reverse iontophoresis.
  59. pmc Repeatability of the evaluation of systemic microvascular endothelial function using laser doppler perfusion monitoring: clinical and statistical implications
    Eduardo Tibirica
    Diabetes Unit, State University of Rio de Janeiro, Brazil
    Clinics (Sao Paulo) 66:599-605. 2011
    ..We investigated the day-to-day repeatability of measures of systemic microvascular reactivity using laser Doppler perfusion monitoring...
  60. ncbi Influence of vehicle resistance on transdermal iontophoretic delivery of acetylcholine and sodium nitroprusside in humans
    Faisel Khan
    Vascular Diseases Research Unit, Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Appl Physiol (1985) 97:883-7. 2004
    b>Iontophoresis is a valuable method of noninvasive drug delivery for assessment of skin microvascular function, but it is important to consider and minimize its potential nonspecific electrical effects on blood flow...
  61. ncbi Topical iontophoresis of valaciclovir hydrochloride improves cutaneous aciclovir delivery
    Nada Abla
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, 1211 Geneva, Switzerland
    Pharm Res 23:1842-9. 2006
    To investigate the topical iontophoresis of valaciclovir (VCV) as a means to improve cutaneous aciclovir (ACV) delivery.
  62. ncbi Non-invasive monitoring of phenytoin by reverse iontophoresis
    Benoît Leboulanger
    School of Pharmacy, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Eur J Pharm Sci 22:427-33. 2004
    Transdermal iontophoresis offers a non-invasive sampling method for therapeutic drug monitoring...
  63. ncbi Iontophoresis-based transdermal delivery systems
    Narayanasamy Kanikkannan
    Division of Pharmaceutics, College of Pharmacy, Florida A and M University, Tallahassee, Florida, USA
    BioDrugs 16:339-47. 2002
    Transdermal iontophoresis is the administration of ionic therapeutic agents through the skin by the application of a low-level electric current...
  64. ncbi Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin
    Patrizia Santi
    Department of Pharmacy, Universita degli Studi di Parma, Parco Area delle Scienze, 27A, Parma 43100, Italy
    Int J Pharm 266:69-75. 2003
    The aim of this work was to study in vitro the post-iontophoresis transport of ibuprofen lysine across rabbit ear skin, from ibuprofen lysine water solutions (20-200 mg/ml and pH 6.8-7.8). Current densities of 0.125, 0.25, and 0...
  65. ncbi Investigation into the potential of iontophoresis facilitated delivery of ketorolac
    Sandip B Tiwari
    Department of Pharmaceutics, College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576119, Karnataka, India
    Int J Pharm 260:93-103. 2003
    The potential for iontophoresis facilitated transdermal transport of ketorolac was investigated using rat skin...
  66. ncbi Prediction of drug release profiles using an intelligent learning system: an experimental study in transdermal iontophoresis
    Chee Peng Lim
    School of Electrical and Electronic Engineering, Engineering Campus, University of Science Malaysia, 14300 Nibong Tebal, Penang, Malaysia
    J Pharm Biomed Anal 31:159-68. 2003
    ..An experimental study in transdermal iontophoresis (TI) is employed to evaluate the applicability of a particular neural network (NN) model, i.e...
  67. ncbi Optimization of aminolevulinic acid delivery by iontophoresis
    Renata F V Lopez
    Centre International de Recherche et d Enseignement, Archamps, France
    J Control Release 88:65-70. 2003
    ..b>Iontophoresis of the predominantly zwitterionic ALA from the anode is more efficient than that from the cathode...
  68. ncbi Endothelial-dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis
    M E Anderson
    Clin Exp Rheumatol 21:403. 2003
  69. ncbi The relation between epinephrine concentration and the anesthetic effect of lidocaine iontophoresis
    Ryo Wakita
    Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Pain Pract 9:115-21. 2009
    We assessed the effect of epinephrine at various concentrations on the anesthetic effect during lidocaine iontophoresis. A solution of 2% lidocaine with epinephrine in concentration of 1:80,000, 1:160,000, 1:320,000, 2% lidocaine plain ..
  70. ncbi The use of iontophoresis in the administration of nicotine and new non-nicotine drugs through the skin for smoking cessation
    José Juan Escobar-Chávez
    División de Estudios de Posgrado Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México, Cuautitlan Izcalli, Estado de Mexico, Mexico
    Curr Drug Discov Technol 6:171-85. 2009
    ..The controlled delivery afforded by constant current iontophoresis, which involves the application of a small electrical potential sets it apart from other technologies...
  71. pmc Simultaneous transdermal extraction of glucose and lactate from human subjects by reverse iontophoresis
    Tak S Ching
    Asia University, Taiwan
    Int J Nanomedicine 3:211-23. 2008
    ..extracting glucose and lactate from human subjects, at the same skin location, using transdermal reverse iontophoresis. Transdermal monitoring using iontophoresis is made possible by the skin's permeability to small molecules and ..
  72. ncbi Iontophoresis: from the lab to the bed side
    M Halhal
    INSERM U 450, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Exp Eye Res 78:751-7. 2004
    Pioneer work on iontophoresis undertaken by David Maurice during the 1970s and 1980s laid the initial groundwork for its potential implementation as a promising ocular therapeutic modality...
  73. ncbi Non-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo
    Valentine Wascotte
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Brussels, Belgium
    Eur J Pharm Biopharm 69:1077-82. 2008
    Reverse iontophoresis uses a small current to extract molecules and ions through the skin...
  74. ncbi High-resolution iontophoresis for single-synapse stimulation
    Jonathan G Murnick
    Department of Biology, RIKEN MIT Neuroscience Research Center, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Neurosci Methods 116:65-75. 2002
    ..We modify the technique of iontophoresis to use a 0...
  75. doi "ChilDrive": a technique of combining regional cutaneous hypothermia with iontophoresis for the delivery of drugs to synovial fluid
    Srinivasa M Sammeta
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    Pharm Res 26:2535-40. 2009
    ..CD is a technique of transdermal delivery of drugs combining regional hypothermia and iontophoresis.
  76. ncbi BOTOX delivery by iontophoresis
    G M Kavanagh
    University Department of Dermatology, The Royal Infirmary of Edinburgh, Lauriston Building, Edinburgh EH3 9YW, Scotland, UK
    Br J Dermatol 151:1093-5. 2004
    ..palmar hyperhidrosis who responded to BOTOX delivered not by injection, the usual method of delivery, but by iontophoresis. The Botulinum molecule has been considered too large for delivery into the skin this way...
  77. pmc Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring
    Tai Ping Sun
    Department of Electrical Engineering, Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou, Taiwan, ROC
    Int J Nanomedicine 5:343-9. 2010
    This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD) and multiwalled carbon nanotubes (MWCNT) epoxy-..
  78. ncbi Factors critical to iontophoretic assessment of vascular reactivity: implications for clinical studies of endothelial dysfunction
    Jane Elizabeth Ramsay
    Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow, Scotland, UK
    J Cardiovasc Pharmacol 39:9-17. 2002
    Skin microvascular responses to iontophoresis of acetylcholine, an endothelium-dependent vasodilator, and sodium nitroprusside, an endothelium-independent vasodilator, were measured using a laser Doppler imager whose software controlled ..
  79. pmc Iodide iontophoresis as a treatment for dry eye syndrome
    J Horwath-Winter
    Department of Ophthalmology, Medical University, Auenbruggerplatz 4, A 8036 Graz, Austria
    Br J Ophthalmol 89:40-4. 2005
    ..In this clinical trial the effectiveness of iodide iontophoresis and iodide application without current in moderate to severe dry eye patients was compared.
  80. ncbi Enhanced delivery of 5-aminolevulinic acid esters by iontophoresis in vitro
    Renata F V Lopez
    School of Pharmacy, University of Geneva, Geneva, Switzerland
    Photochem Photobiol 77:304-8. 2003
    ..b>Iontophoresis of methyl-ALA and hexyl-ALA also increased the amount of prodrug delivered into the skin...
  81. ncbi Regulation of human cutaneous circulation evaluated by laser Doppler flowmetry, iontophoresis, and spectral analysis: importance of nitric oxide and prostaglandines
    Per Kvandal
    Department of Anesthesiology, Ulleval University Hospital, 0407 Oslo, Norway
    Microvasc Res 65:160-71. 2003
    ..Basal cutaneous perfusion and perfusion responses during iontophoresis with the endothelium-dependent vasodilator acetylcholine (ACh) and the endothelium-independent vasodilator ..
  82. ncbi Reverse iontophoresis for non-invasive transdermal monitoring
    Benoît Leboulanger
    School of Pharmacy, University of Geneva, 30 quai Ernest Ansermet CH 1211 Geneva 4, Switzerland
    Physiol Meas 25:R35-50. 2004
    b>Iontophoresis is the application of a small electric current to enhance the transport of both charged and polar, neutral compounds across the skin...
  83. ncbi Transdermal delivery of insulin from poloxamer gel: ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers
    Omathanu Pillai
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, 160062, Punjab, India
    J Control Release 89:127-40. 2003
    Gels are considered to be the most suitable delivery vehicle for iontophoresis, as they can be easily amalgamated with the iontophoretic delivery system and can also match the contours of the skin...
  84. ncbi Hydrogel probe for iontophoresis drug delivery to the eye
    Esther Eljarrat-Binstock
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Biomater Sci Polym Ed 15:397-413. 2004
    ..hydrogel loaded with a drug solution as a probe for ejecting drugs to the eye upon application of low current iontophoresis. Hydroxyethyl methacrylate (HEMA), cross-linked with ethylene glycol dimethacrylate (EGDMA), and cross-linked ..
  85. ncbi Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers
    Omathanu Pillai
    Department of Pharmaceutics, National Institute of Pharmaceutical, Education and Research NIPER, Sector 67, SAS Nagar 160 062, Punjab, India
    Int J Pharm 269:109-20. 2004
    Transdermal iontophoresis per se may not be able to achieve significant permeation of large peptides like insulin, thereby necessitating the use of combination strategies involving chemical enhancers and iontophoresis...
  86. ncbi Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis
    Marvin E Myles
    Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA, USA
    Adv Drug Deliv Rev 57:2063-79. 2005
    ..This review will summarize recent literature concerning ocular drug delivery of bioactive compounds to the posterior segment of the eye with emphasis on transscleral iontophoresis.
  87. ncbi Iontophoresis and sonophoresis stimulate epidermal cytokine expression at energies that do not provoke a barrier abnormality: lamellar body secretion and cytokine expression are linked to altered epidermal calcium levels
    Eung Ho Choi
    Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea
    J Invest Dermatol 121:1138-44. 2003
    ..b>Iontophoresis and sonophoresis with the energies that do not disrupt the skin barrier, but induce changes in the epidermal ..
  88. pmc Cystic fibrosis in Korean children:a case report identified by a quantitative pilocarpine iontophoresis sweat test and genetic analysis
    Kang Mo Ahn
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 20:153-7. 2005
    ..in both lungs, and their diagnosis was confirmed by the repeated analysis of a quantitative pilocarpine iontophoresis test (QPIT). The sweat chloride concentrations of the first patient were 108.1 mM/L and 96.7 mM/L...
  89. ncbi Compartmental modeling of transdermal iontophoretic transport: I. In vitro model derivation and application
    Akhmad Kharis Nugroho
    Leiden Amsterdam Center for Drug Research, 2300 RA Leiden, The Netherlands
    Pharm Res 21:1974-84. 2004
    ..The objective of this study was to develop a family of compartmental models to describe in a strictly quantitative manner the transdermal iontophoretic transport of drugs in vitro...
  90. ncbi Simultaneous extraction of urea and glucose by reverse iontophoresis in vivo
    Anke Sieg
    School of Pharmacy, University of Geneva, 1211 Geneva 4, Switzerland
    Pharm Res 21:1805-10. 2004
    Reverse iontophoresis extracts glucose across the skin in the GlucoWatch Biographer, a device to monitor glycemia in diabetes...
  91. ncbi Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery
    Yiping Wang
    Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
    Eur J Pharm Biopharm 60:179-91. 2005
    ..A number of other physical approaches such as iontophoresis, sonophoresis, ultrasound and the use of microneedles are now being studied to improve permeation of ..
  92. ncbi Transcorneal and transscleral iontophoresis of dexamethasone phosphate using drug loaded hydrogel
    Esther Eljarrat-Binstock
    Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Control Release 106:386-90. 2005
    To evaluate dexamethasone penetration to the eye after a short transcorneal and transscleral iontophoresis using a drug loaded hydrogel assembled on a portable iontophoretic device.
  93. ncbi Lidocaine iontophoresis versus EMLA cream for CO2 laser treatment in seborrheic keratosis
    Rosaya Phahonthep
    Division of Dermatology, Department of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    J Med Assoc Thai 87:S15-8. 2004
    ..Topical anesthesia for skin surgery has widely been used for a long time. Various preparations are used. The EMLA cream is the most popular one...
  94. ncbi Tolerance of ocular iontophoresis in healthy volunteers
    Thomas M Parkinson
    Research and Development, IOMED, Inc, Salt Lake City, Utah 84120 9941, USA
    J Ocul Pharmacol Ther 19:145-51. 2003
    ..The OcuPhor trade mark system has promise for noninvasive drug delivery to the eye...
  95. ncbi Wavelet analysis of blood flow dynamics: effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes
    Mitja Veber
    Group of Nonlinear Dynamics and Synergetics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia
    Phys Med Biol 49:N111-7. 2004
    b>Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties...
  96. ncbi Delivery of antisense oligonucleotide to the cornea by iontophoresis
    M Berdugo
    Association Claude Bermond, INSERM U450, Paris, France
    Antisense Nucleic Acid Drug Dev 13:107-14. 2003
    We wished to evaluate the potential of iontophoresis to promote the delivery of antisense oligonucleotides (ODN) directed at the vascular endothelial growth factor (VEGF)-R2 receptor (KDR/Flk) to the cornea of the rat eye...
  97. ncbi Iontophoresis of antibiotics into segmental allografts
    P P C Khoo
    Department of Orthopaedic Surgery, Medical Engineering and Physics Department Royal Perth Hospital, Wellington Street Campus, Box X2213 GPO, Perth, Western Australia 6847, Australia
    J Bone Joint Surg Br 88:1149-57. 2006
    b>Iontophoresis is a novel technique which may be used to facilitate the movement of antibiotics into the substance of bone using an electrical potential applied externally...
  98. ncbi Down-regulation of NOSII gene expression by iontophoresis of anti-sense oligonucleotide in endotoxin-induced uveitis
    M Voigt
    INSERM U450 15 rue de l Ecole de Médecine, 75270 Paris Cedex 6, France
    Biochem Biophys Res Commun 295:336-41. 2002
    Transcorneoscleral iontophoresis was used to enhance ocular penetration of a 21-bp NH(2) protected anti-NOSII oligonucleotides (ODNs) (fluorescein or infrared-41 labeled) in Lewis rats...
  99. pmc Prior iontophoresis of saline enhances vasoconstriction to phenylephrine and clonidine in the skin of the human forearm
    Peter D Drummond
    School of Psychology, Murdoch University, Perth, Western Australia
    Br J Clin Pharmacol 54:45-50. 2002
    ..To determine whether postjunctional alpha1- and alpha2-adrenoceptors mediate vasoconstrictor responses in the cutaneous vasculature of the human forearm...
  100. ncbi Piroxicam delivery into human stratum corneum in vivo: iontophoresis versus passive diffusion
    C Curdy
    Centre Interuniversitaire de Recherche et d'Enseignement, Universities of Geneva and Lyon, Campus Universitaire, Parc d'Affaires International, F-74166, Archamps, France
    J Control Release 76:73-9. 2001
    ..The total amount of drug recovered in the SC post-iontophoresis was significantly higher than that found following passive diffusion for each application time...
  101. ncbi Transdermal iontophoresis of insulin. V. Effect of terpenes
    Omathanu Pillai
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, Section 67, SAS Nagar, 160 062 Punjab, India
    J Control Release 88:287-96. 2003
    ..for 2 h with 5% of menthol, menthone, cineole and pulegone in EtOH; EtOH alone; neat menthone with and without iontophoresis (0.5 mA/cm(2); 6 h)...

Research Grants72

  1. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    Bruce Hinds; Fiscal Year: 2009
    ..20/sq.ft. This membrane would also be expected to have minimal skin irritation potential as compared to iontophoresis, the current non-invasive programmable drug delivery method that could eventually compete with this system on ..
  2. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..devices to compare delivery methods that include, but need not be limited to: electroporation, sonoporation, iontophoresis, liquid jets, microneedles and topical formulations. The work and discoveries made by the major U.S...
  3. Delivery of biologically active nucleic acids to epidermal cells
    ROGER KASPAR; Fiscal Year: 2009
    ..devices to compare delivery methods that include, but need not be limited to: electroporation, sonoporation, iontophoresis, liquid jets, microneedles and topical formulations. The work and discoveries made by the major U.S...
  4. Low-dose Aspirin and Human Skin Blood Flow
    Lacy A Holowatz; Fiscal Year: 2010
    ..VD via shear-stress mechanisms with and without the localized sympathetic adrenergic control intact (bretylium iontophoresis)...
  5. Improved Method of Drug Delivery to the Inner Ear
    S Kevin Li; Fiscal Year: 2010
    ..delivery to the inner ear using a sustained release temperature sensitive gel and controlled delivery using iontophoresis. A temperature sensitive gel system that is a liquid at room temperature to conform on the round window niche ..
  6. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    BRUCE JACKSON HINDS; Fiscal Year: 2010
    ..20/sq.ft. This membrane would also be expected to have minimal skin irritation potential as compared to iontophoresis, the current non-invasive programmable drug delivery method that could eventually compete with this system on ..
  7. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    Bruce Hinds; Fiscal Year: 2007
    ..20/sq.ft. This membrane would also be expected to have minimal skin irritation potential as compared to iontophoresis, the current non-invasive programmable drug delivery method that could eventually compete with this system on ..
  8. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    Bruce Hinds; Fiscal Year: 2006
    ..20/sq.ft. This membrane would also be expected to have minimal skin irritation potential as compared to iontophoresis, the current non-invasive programmable drug delivery method that could eventually compete with this system on ..
  9. IONTOPHORESIS OF ANTIVIRALS TO HERPES EYE INFECTIONS
    James Hill; Fiscal Year: 1980
    b>Iontophoresis is a method for administering charged drugs; application of an electrical current assists penetration of drugs into surface tissues...
  10. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
    ..aversive (quinine) tastant. Aim 4 will expand that study and apply our improved iontophoresis method in conjunction with the combined voltammetry/electrophysiology technology to determine potential causal ..
  11. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
    ..aversive (quinine) tastant. Aim 4 will expand that study and apply our improved iontophoresis method in conjunction with the combined voltammetry/electrophysiology technology to determine potential causal ..
  12. NORADRENERGIC CONTROL OF THE UPPER AIRWAY
    Leszek Kubin; Fiscal Year: 2002
    ..mRNAs are present in the XII nucleus and how their levels change following mn degeneration; and 3) using NE iontophoresis onto the single XII mns, whether there is a functional amplification of the central respiratory drive...
  13. NORADRENERGIC CONTROL OF THE UPPER AIRWAY
    Leszek Kubin; Fiscal Year: 1999
    ..mRNAs are present in the XII nucleus and how their levels change following mn degeneration; and 3) using NE iontophoresis onto the single XII mns, whether there is a functional amplification of the central respiratory drive...
  14. NORADRENERGIC CONTROL OF THE UPPER AIRWAY
    Leszek Kubin; Fiscal Year: 2000
    ..mRNAs are present in the XII nucleus and how their levels change following mn degeneration; and 3) using NE iontophoresis onto the single XII mns, whether there is a functional amplification of the central respiratory drive...
  15. NORADRENERGIC CONTROL OF THE UPPER AIRWAY
    Leszek Kubin; Fiscal Year: 2001
    ..mRNAs are present in the XII nucleus and how their levels change following mn degeneration; and 3) using NE iontophoresis onto the single XII mns, whether there is a functional amplification of the central respiratory drive...
  16. ELECTRICALLY MODULATED SKIN DELIVERY OF BETA-BLOCKERS
    Ajay Banga; Fiscal Year: 2000
    ..In vitro studies will involve development of electrical parameters for iontophoresis alone (e.g., current density) or in combination with electroporation (e.g...
  17. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1992
    ..These studies would employ novel drug delivery methods (iontophoresis and collagen shields) capable of delivering large amounts of antibiotic in a short time, as well as two rabbit ..
  18. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1991
    ..These studies would employ novel drug delivery methods (iontophoresis and collagen shields) capable of delivering large amounts of antibiotic in a short time, as well as two rabbit ..
  19. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 1993
    ..These studies would employ novel drug delivery methods (iontophoresis and collagen shields) capable of delivering large amounts of antibiotic in a short time, as well as two rabbit ..
  20. INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 2002
    ..During the coming grant period, norepinephrine iontophoresis in patients with and without SMP will be tested as a new, non-invasive, diagnostic test for SMP (Sp. Aim 1)...
  21. INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 2003
    ..During the coming grant period, norepinephrine iontophoresis in patients with and without SMP will be tested as a new, non-invasive, diagnostic test for SMP (Sp. Aim 1)...
  22. INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 2001
    ..During the coming grant period, norepinephrine iontophoresis in patients with and without SMP will be tested as a new, non-invasive, diagnostic test for SMP (Sp. Aim 1)...
  23. INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 2004
    ..During the coming grant period, norepinephrine iontophoresis in patients with and without SMP will be tested as a new, non-invasive, diagnostic test for SMP (Sp. Aim 1)...
  24. INJURY-INDUCES PAIN-- CHEMICAL MODULATION OF NOCICEPTORS
    Srinivasa Raja; Fiscal Year: 2000
    ..During the coming grant period, norepinephrine iontophoresis in patients with and without SMP will be tested as a new, non-invasive, diagnostic test for SMP (Sp. Aim 1)...
  25. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    ROBERT MARK WIGHTMAN; Fiscal Year: 2010
    ..5. Iontophoresis coupled with voltammetry...
  26. A NEW CHLORIDE SWEAT TEST FOR CYSTIC FIBROSIS SCREENING
    WARREN WARWICK; Fiscal Year: 2003
    ..three new methods of transporting pilocarpine to the sweat glands and comparing the results to the current iontophoresis method...
  27. A NEW CHLORIDE SWEAT TEST FOR CYSTIC FIBROSIS SCREENING
    WARREN WARWICK; Fiscal Year: 2004
    ..three new methods of transporting pilocarpine to the sweat glands and comparing the results to the current iontophoresis method...
  28. DIFFUSION OF SUBSTANCES THROUGH THE BRAIN
    Charles Nicholson; Fiscal Year: 1999
    ..The work will use a micropipette as a point-source to release molecules into the brain by iontophoresis, a pressure pulse or a controlled infusion...
  29. TESTOSTERONE INFLUENCE ON VOMERONASAL NEURON MORPHOLOGY
    Sarah Newman; Fiscal Year: 1990
    ..These projections will be studied after iontophoresis of the orthogradely transported tracer Phaseolus vulgaris leucoagglutinin into rostral M and, in other ..
  30. CONTROL OF AIRWAY MOTOR NEURONS DURING SLEEP/WAKEFULNESS
    Jerome Siegel; Fiscal Year: 2002
    ..These studies will use in vivo microdialysis, intracellular unit recording and iontophoresis. This program will bring basic science techniques to bear on the important clinical problem of sleep apnea...
  31. CONTROL OF AIRWAY MOTOR NEURONS DURING SLEEP/WAKEFULNESS
    Jerome Siegel; Fiscal Year: 1999
    ..These studies will use in vivo microdialysis, intracellular unit recording and iontophoresis. This program will bring basic science techniques to bear on the important clinical problem of sleep apnea...
  32. CONTROL OF AIRWAY MOTOR NEURONS DURING SLEEP/WAKEFULNESS
    Jerome Siegel; Fiscal Year: 2001
    ..These studies will use in vivo microdialysis, intracellular unit recording and iontophoresis. This program will bring basic science techniques to bear on the important clinical problem of sleep apnea...
  33. CONTROL OF AIRWAY MOTOR NEURONS DURING SLEEP/WAKEFULNESS
    Jerome Siegel; Fiscal Year: 2000
    ..These studies will use in vivo microdialysis, intracellular unit recording and iontophoresis. This program will bring basic science techniques to bear on the important clinical problem of sleep apnea...
  34. DESCENDING MODULATION OF SPINAL SUBSTANTIA GELATINOSA
    ALAN LIGHT; Fiscal Year: 1980
    ..b>Iontophoresis of intracellular labels will be used to identify the recorded neurons at both light and EM levels...
  35. NEURAL SYSTEMS OF TASTE AND INGESTIVE BEHAVIOR
    Ralph Norgren; Fiscal Year: 1991
    ..will provide an opportunity to learn, develop, or improve numerous techniques, including extracellular iontophoresis, chronic electrophysiology, animal psychophysical procedures and stimulus control, as well as to continue and ..
  36. NEURAL SYSTEMS OF TASTE AND INGESTIVE BEHAVIOR
    Ralph Norgren; Fiscal Year: 1992
    ..will provide an opportunity to learn, develop, or improve numerous techniques, including extracellular iontophoresis, chronic electrophysiology, animal psychophysical procedures and stimulus control, as well as to continue and ..
  37. Evaluation of siRNA uptake and functional activity in a human organotypic skin mo
    Roger L Kaspar; Fiscal Year: 2010
    ..be used in combination with our stratum corneum delivery technologies (GeneCream, microneedle arrays and/or iontophoresis)...
  38. Nociceptor Maturation and Response to Peripheral Injury
    CHARLES WOODBURY; Fiscal Year: 2009
    ..characterized using a comprehensive suite of natural skin stimuli and then labeled in their entirety through iontophoresis of Neurobiotin...
  39. BRAIN REGULATION OF GASTRIC FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 1990
    ..on gastric branch of the vagus and splanchnic nerve, of single cell unit using the technique of combined iontophoresis and single cell microelectrode recording...
  40. MEDULLARY CIRCUITRY INVOLVED IN OPIOID ANALGESIA
    Mary Heinricher; Fiscal Year: 1993
    ..of neurons, termed "on-cells", show a naloxone-reversible decrease in firing rate when morphine is applied by iontophoresis. On-cells are characterized by an abrupt increase in firing just prior to the occurrence of nocifensive ..
  41. PEPTIDES IN ADULT & DEVELOPING CEREBELLAR CIRCUITS
    James King; Fiscal Year: 1990
    ..b>Iontophoresis of peptides, immunohistochemistry, in situ hybirdization, and double labeling paradigms using retrograde ..
  42. Novel Method for the Ocular Iontophoretic Delivery of Avastin and Lucentis
    William I Higuchi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Iontophoresis is a method of using a mild electrical current to enhance the penetration of a drug through tissue...
  43. OCULAR HSV: LATENCY, REACTIVATION, & RECURRENCE
    James Hill; Fiscal Year: 1991
    ..shedding and recurrent epithelial disease will continue in two previously developed rabbit models: 1) ocular iontophoresis of adrenergic agents, and 2) production of adrenergic agonists and antagonists will be used to define the ..
  44. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2006
    ..A less invasive method will use cutaneous iontophoresis of substance P to evoke a facilitated vasodilatation response measured by laser Doppler...
  45. OCULAR HSV: LATENCY, REACTIVATION, & RECURRENCE
    James Hill; Fiscal Year: 1990
    ..shedding and recurrent epithelial disease will continue in two previously developed rabbit models: 1) ocular iontophoresis of adrenergic agents, and 2) production of adrenergic agonists and antagonists will be used to define the ..
  46. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2007
    ..2. To develop and use iontophoresis with voltammetry to introduce chemical substances directly at the site where pH and dopamine measurements are ..
  47. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2004
    ..A less invasive method will use cutaneous iontophoresis of substance P to evoke a facilitated vasodilatation response measured by laser Doppler...
  48. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2006
    ..2. To develop and use iontophoresis with voltammetry to introduce chemical substances directly at the site where pH and dopamine measurements are ..
  49. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2005
    ..A less invasive method will use cutaneous iontophoresis of substance P to evoke a facilitated vasodilatation response measured by laser Doppler...
  50. NEUROPEPTIDES IN THE CONTROL OF REPRODUCTIVE BEHAVIOR
    Qin Gu; Fiscal Year: 1992
    ..and tract tracing (retrograde) methods; electrolytic lesions; brain cannulation; extracellular recording; iontophoresis and behavioral analysis...
  51. On-line Study of Error Adjustment, Adaptation, and Skill Learning
    Scott Grafton; Fiscal Year: 2003
    ..B). Micro-stimulation and NMDA iontophoresis of small regions of M1. C)...
  52. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2002
    ..A less invasive method will use cutaneous iontophoresis of substance P to evoke a facilitated vasodilatation response measured by laser Doppler...
  53. ANTICONVULSANT-CONVULSANT ACTIONS IN CULTURED NEURONS
    Robert MacDonald; Fiscal Year: 1980
    ..of cultured murine spinal cord and cerebellar neurons using intracellular recording techniques coupled with a) iontophoresis of drugs and putative neurotransmitters and b) anatomical study of neuronal morphology and synaptic ..
  54. NEUROPEPTIDES IN THE CONTROL OF REPRODUCTIVE BEHAVIOR
    Qin Gu; Fiscal Year: 1993
    ..and tract tracing (retrograde) methods; electrolytic lesions; brain cannulation; extracellular recording; iontophoresis and behavioral analysis...
  55. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2003
    ..A less invasive method will use cutaneous iontophoresis of substance P to evoke a facilitated vasodilatation response measured by laser Doppler...
  56. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 1993
    ..The methodology to be employed includes iontophoresis of adrenergic agents,...
  57. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2006
    ..Combinations of single unit recording, microinjections, behavioral testing and iontophoresis will be performed to reveal the neurophysiological basis for improgan antinociception...
  58. FUNCTIONAL HYPEREMIA--PERIPHERAL AND CENTRAL INTERACTION
    STEVEN SEGAL; Fiscal Year: 1990
    ..In cheek pouch arterioles, propagated vasodilation (PVD) induced with acetylcholine iontophoresis has been defined as an increase in the diameter of resistance vessels at sites well removed from the initial ..
  59. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2007
    ..Combinations of single unit recording, microinjections, behavioral testing and iontophoresis will be performed to reveal the neurophysiological basis for improgan antinociception...
  60. SPINAL AND PROJECTION MECHANISMS RELATED TO PAIN
    EDWARD PERL; Fiscal Year: 1992
    ..Functionally characterized dorsal root ganglion cells, marked intracellularly by iontophoresis with a label (lucifer yellow, HRP) from recording micropipettes, would be tested for reactivity with ..
  61. SPINAL AND PROJECTION MECHANISMS RELATED TO PAIN
    EDWARD PERL; Fiscal Year: 1991
    ..Functionally characterized dorsal root ganglion cells, marked intracellularly by iontophoresis with a label (lucifer yellow, HRP) from recording micropipettes, would be tested for reactivity with ..
  62. SPINAL AND PROJECTION MECHANISMS RELATED TO PAIN
    EDWARD PERL; Fiscal Year: 1990
    ..Functionally characterized dorsal root ganglion cells, marked intracellularly by iontophoresis with a label (lucifer yellow, HRP) from recording micropipettes, would be tested for reactivity with ..
  63. Transdermal GnRH Delivery System to Treat Infertility
    Kenneth Swartz; Fiscal Year: 2006
    ..Sensor Technologies (AST) proposes to develop a wearable transdermal Pulse Patch that incorporates a micro-iontophoresis system, constructed using CMOS circuitry technology, and a polymer matrix electrolyte reservoir containing ..
  64. OCULAR HSV--LATENCY, REACTIVATION, AND RECURRENCE
    James Hill; Fiscal Year: 1992
    ..The methodology to be employed includes iontophoresis of adrenergic agents,...
  65. SPINAL NEURON EXCITABILITY DURING VOLUNTARY MOVEMENT
    Steve Perlmutter; Fiscal Year: 2002
    ..Inhibitory and neuromodulator inputs to spinal neurons will be manipulated with local iontophoresis of pharmacological agents that activate or block serotonin,, noradrenaline, GABA or glycine receptors...
  66. SPINAL NEURON EXCITABILITY DURING VOLUNTARY MOVEMENT
    Steve Perlmutter; Fiscal Year: 2003
    ..Inhibitory and neuromodulator inputs to spinal neurons will be manipulated with local iontophoresis of pharmacological agents that activate or block serotonin,, noradrenaline, GABA or glycine receptors...