intramuscular injections

Summary

Summary: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.

Top Publications

  1. doi Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 167:181-9. 2010
  2. ncbi Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia
    K A Sluka
    Physical Therapy Graduate Program, 2600 Steindler Bldg, University of Iowa, Iowa City, Iowa 52242, USA
    Muscle Nerve 24:37-46. 2001
  3. pmc Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats
    Luis F Da Silva
    Graduate Program in Physical Therapy and Rehabilitation Sciences, Neuroscience Graduate Program, Pain Research Program, The University of Iowa, Iowa City
    J Pain 11:378-87. 2010
  4. ncbi A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:1733-42. 2003
  5. ncbi Pharmacokinetics of doxycycline after administration as a single intravenous bolus and intramuscular doses to non-lactating Egyptian goats
    A M Abd El-Aty
    Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12515 Giza, Egypt
    Pharmacol Res 49:487-91. 2004
  6. pmc Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
    Simon R Best
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Vaccine 27:5450-9. 2009
  7. ncbi Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial
    Anthony Howell
    Christie Hospital and Holt Radium Institute, Manchester, UK
    J Clin Oncol 22:1605-13. 2004
  8. pmc Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, I: analysis of cases
    Holland C Detke
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    BMC Psychiatry 10:43. 2010
  9. pmc Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle
    Z Li
    Station Centrale de Microscopie Electronique, Institut Pasteur, Paris, France
    J Cell Biol 139:129-44. 1997
  10. ncbi Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines
    R J Cox
    Influenza Research Centre Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 59:1-15. 2004

Research Grants

  1. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2010
  2. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - DCC
    ELIZABETH ANN THOM; Fiscal Year: 2010
  3. Oral Testosterone for Male Hormonal Contraception
    John K Amory; Fiscal Year: 2011
  4. Controlling Radiation Injury by TLR5 Agonists
    Andrei Gudkov; Fiscal Year: 2009
  5. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2002
  6. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2006
  7. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2003
  8. DERMALLY APPLIED T GEL PREPARATION IN HYPOGONADAL MALES
    Thomas Weber; Fiscal Year: 2001
  9. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2004
  10. DERMALLY APPLIED T GEL PREPARATION IN HYPOGONADAL MALES
    Thomas Weber; Fiscal Year: 1999

Detail Information

Publications284 found, 100 shown here

  1. doi Olanzapine long-acting injection: a 24-week, randomized, double-blind trial of maintenance treatment in patients with schizophrenia
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 167:181-9. 2010
    ..The purpose of the present study was to evaluate the efficacy and tolerability of olanzapine long-acting injection for maintenance treatment of schizophrenia...
  2. ncbi Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia
    K A Sluka
    Physical Therapy Graduate Program, 2600 Steindler Bldg, University of Iowa, Iowa City, Iowa 52242, USA
    Muscle Nerve 24:37-46. 2001
    This study characterizes an animal model of persistent mechanical hyperalgesia induced by repeated intramuscular injections of low pH saline. Saline at pH 4, 5, 6, or 7...
  3. pmc Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats
    Luis F Da Silva
    Graduate Program in Physical Therapy and Rehabilitation Sciences, Neuroscience Graduate Program, Pain Research Program, The University of Iowa, Iowa City
    J Pain 11:378-87. 2010
    ..of the NMDA receptors in the RVM and NGC in muscle and cutaneous hypersensitivity induced by repeated intramuscular injections of acidic saline...
  4. ncbi A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:1733-42. 2003
    ..Anabolic steroids could be an additional mode of intervention to improve outcome of pulmonary rehabilitation by increasing physiologic functioning, possibly mediated by increasing erythropoietic function...
  5. ncbi Pharmacokinetics of doxycycline after administration as a single intravenous bolus and intramuscular doses to non-lactating Egyptian goats
    A M Abd El-Aty
    Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12515 Giza, Egypt
    Pharmacol Res 49:487-91. 2004
    ..The extent of serum protein binding percent was 32.8% and the systemic bioavailability was 99.40% after i.m. injection of 5 mg kg-1 BW..
  6. pmc Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery
    Simon R Best
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Vaccine 27:5450-9. 2009
    ..We conclude that electroporation is a promising method for delivery of HPV DNA vaccines and should be considered for DNA vaccine delivery in human clinical trials...
  7. ncbi Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial
    Anthony Howell
    Christie Hospital and Holt Radium Institute, Manchester, UK
    J Clin Oncol 22:1605-13. 2004
    ....
  8. pmc Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, I: analysis of cases
    Holland C Detke
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    BMC Psychiatry 10:43. 2010
    ..During clinical trials, a post-injection syndrome characterized by signs of delirium and/or excessive sedation was identified in a small percentage of patients following injection with olanzapine LAI...
  9. pmc Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle
    Z Li
    Station Centrale de Microscopie Electronique, Institut Pasteur, Paris, France
    J Cell Biol 139:129-44. 1997
    ..The results presented here show that desmin is essential to maintain the structural integrity of highly solicited skeletal muscle...
  10. ncbi Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines
    R J Cox
    Influenza Research Centre Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 59:1-15. 2004
    ..In contrast, the CAV may elicit a long-lasting, broader immune (humoral and cellular) response, which more closely resembles natural immunity. The immune response induced by these two vaccines will be compared in this review...
  11. ncbi Nerve injuries following intramuscular injections: a clinical and neurophysiological study from Northwest India
    Jeyaraj Durai Pandian
    Department of Neurology, Christian Medical College, Ludhiana, Punjab, India
    J Peripher Nerv Syst 11:165-71. 2006
    In developing countries, injections are frequently used to treat common ailments. Intramuscular injections (IMI) may damage peripheral nerves at the site of injection...
  12. ncbi Evidence for the use of intramuscular injections in outpatient practice
    Mark Shatsky
    Providence Medical Group, Portland, Oregon, USA
    Am Fam Physician 79:297-300. 2009
    ..For other indications, the intramuscular route should be considered only when the delivery of a medication must be confirmed, such as when a patient cannot tolerate an oral medication, or when compliance is uncertain...
  13. ncbi [Body building aided by intramuscular injections of walnut oil]
    I C Munch
    Sygehus Vestsjaelland, ortopaedkirurgisk afdeling
    Ugeskr Laeger 163:6758. 2001
    ..Injections of oil may cause foreign body reactions, leading to tumours named according to the injected material; e.g. paraffinoma, oleoma. Systemic distribution has been reported to result in pulmonary complications...
  14. ncbi Effective exon skipping and restoration of dystrophin expression by peptide nucleic acid antisense oligonucleotides in mdx mice
    HaiFang Yin
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Mol Ther 16:38-45. 2008
    ..Furthermore, single intramuscular injections of PNA and all PNA-peptide conjugates resulted in significant numbers of dystrophin-positive fibers in ..
  15. ncbi Treatment of chronic tension-type headache with botulinum toxin: a double-blind, placebo-controlled clinical trial
    M Padberg
    Department of Neurology and Clinical Neurophysiology, Leyenburg Hospital, The Hague, The Netherlands
    Cephalalgia 24:675-80. 2004
    ..Botulinum toxin was not proven effective in treatment of chronic tension-type headache. Increased muscle tenderness might not be as important in pathophysiology of chronic tension-type headache as hitherto believed...
  16. ncbi The use of botulinum toxin in the treatment of headaches
    Alexander Mauskop
    New York Headache Center, 30 East 76th Street, New York, NY 10021, USA
    Curr Pain Headache Rep 6:320-3. 2002
    ..This makes botulinum toxin a preferred treatment for many patients. The large controlled trials that are underway may lead to a wider acceptance of this treatment by neurologists and pain specialists...
  17. ncbi Botulinum toxin type A as an effective prophylactic treatment in primary headache disorders
    Andrew Blumenfeld
    San Diego, CA 92130, USA
    Headache 43:853-60. 2003
    ..To measure the effect of botulinum toxin type A (Botox, Allergan, Inc, Irvine, CA) treatment in 271 patients diagnosed with headache in accordance with International Headache Society (IHS) criteria...
  18. ncbi Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity
    Baowei Peng
    School of Pharmacy, Shanghai Jiaotong University, 1954 Hua Shan Rd, Shanghai 200030, PR China
    Vaccine 25:2064-73. 2007
    ..Based on these observations, we proposed that the local inflammation resulted from EP treatment played an important role in facilitating antigen presentation of the DNA vaccines...
  19. pmc Comparison of the selection of antimicrobial resistance in fecal Escherichia coli during enrofloxacin administration with a local drug delivery system or with intramuscular injections in a swine model
    Romain Béraud
    Department of Clinical Sciences, Faculte de Medecine Veterinaire, Universite de Montreal
    Can J Vet Res 72:311-9. 2008
    ..This could represent another advantage of LDDS usage compared to long-lasting systemic administration of fluoroquinolones...
  20. ncbi Dystrophin expression in the mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide
    Susan Fletcher
    Experimental Molecular Medicine Group, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Nedlands, Perth, Western Australia, 6097
    J Gene Med 8:207-16. 2006
    ..The antisense oligonucleotide chemistry most widely used to alter pre-mRNA processing is 2'-O-methyl-modified bases on a phosphorothioate backbone...
  21. ncbi Botulinum toxin therapy of migraine and tension-type headache: comparing different botulinum toxin preparations
    W J Schulte-Mattler
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Eur J Neurol 13:51-4. 2006
    ..Experience with botulinum toxin type B (Myobloc/NeuroBloc) is limited and similar to the experience with the type A. Thus, a widespread use of botulinum toxin therapy in headache can currently not be recommended...
  22. ncbi Botulinum toxin type A for migraine prophylaxis in the Japanese population: an open-label prospective trial
    Kosuke Suzuki
    Department of Neurology, School of Medicine, Kitasato University, Sagamihara
    Intern Med 46:959-63. 2007
    ..To evaluate the efficacy and tolerability of Botulinum Toxin Type A (BoNT-A) for migraine prophylaxis...
  23. ncbi Correlates of pediatric behavior and distress during intramuscular injections for invasive dental procedures
    Lindsey L Cohen
    Department of Psychology, Georgia State University, 1102 Urban Life, 140 Decatur Street, Atlanta, GA 30302 5010, USA
    J Clin Pediatr Dent 31:44-7. 2006
    ..behavior, temperament, and procedure-related behavior and distress were examined in children receiving intramuscular injections before undergoing restorative dental procedures...
  24. ncbi Botulinum toxin type A for the prophylactic treatment of chronic daily headache: a randomized, double-blind, placebo-controlled trial
    Stephen D Silberstein
    Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mayo Clin Proc 80:1126-37. 2005
    ..To identify a treatment-responsive population for botulinum toxin type A (BoNTA) and to evaluate the safety and efficacy of 3 different doses of BoNTA as prophylactic treatment of chronic daily headache (CDH)...
  25. pmc Outbreak of Mycobacterium massiliense infection associated with intramuscular injections
    Hee Youn Kim
    Department of Microbiology, Cancer Research Institute, Institute of Endemic Diseases, SNUMRC, Korea
    J Clin Microbiol 45:3127-30. 2007
    Twelve strains of a rapidly growing Mycobacterium species were isolated from an outbreak associated with intramuscular injections of an antimicrobial agent and were identified by comparative sequence analysis of rpoB and hsp65...
  26. pmc Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 82:6458-69. 2008
    ..These findings demonstrate that the route and dose of DNA vaccines significantly impact the quality of immune responses, yielding important information for future vaccine design...
  27. pmc Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life
    C J Malkin
    Department of Cardiology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Heart 90:871-6. 2004
    ..Testosterone has been reported to improve symptoms of angina and delay time to ischaemic threshold in unselected men with coronary disease...
  28. ncbi Botulinum toxin for the treatment of headaches: a review of current practices and evidence based-data
    Yesim Ates
    Ankara University Medical Faculty, Department Of Anesthesiology and Reanimation and Algology, Ankara, Turkey
    Agri 18:5-11. 2006
    ..In this manuscript use of botulinum toxin is reviewed with special emphasize on its mechanism of effect, injection techniques and recent evidence-based data...
  29. ncbi An 8-week, double-blind, randomized, placebo-controlled study of olanzapine long-acting injection in acutely ill patients with schizophrenia
    John Lauriello
    Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 001, USA
    J Clin Psychiatry 69:790-9. 2008
    ..To examine the efficacy and tolerability of a new injectable formulation of olanzapine, olanzapine long-acting injection (LAI), relative to placebo for treatment of acutely ill patients with schizophrenia...
  30. pmc Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids
    F Shojaee Aliabadi
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, United Kingdom
    Antimicrob Agents Chemother 47:626-35. 2003
    ..8, 20.2, and 28.7 h, and slightly higher values were obtained for transudate and exudate. It is proposed that use of these data might provide a novel approach to the rational design of dosage schedules...
  31. pmc Safety and immunogenicity of adenovirus-vectored near-consensus HIV type 1 clade B gag vaccines in healthy adults
    Clayton D Harro
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 25:103-14. 2009
    ..Preexistent and/or vaccine-induced immunity to the Ad5 vector may dampen the CMI response to HIV Gag...
  32. pmc Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine
    D J Briggs
    College of Veterinary Medicine, Kansas State University, USA
    Bull World Health Organ 78:693-8. 2000
    ..We conclude that PCECV is a safe and highly immunogenic vaccine for postexposure rabies vaccination when administered intradermally in 0.1-ml doses using the two-site method ("2,2,2,0,1,1") recommended by WHO...
  33. ncbi Antibody responses after dose-sparing intradermal influenza vaccination
    Prasert Auewarakul
    Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Vaccine 25:659-63. 2007
    ....
  34. ncbi Unilateral versus bilateral injections of botulinum toxin in patients with adductor spasmodic dysphonia
    Steven Bielamowicz
    Voice Treatment Center, Division of Otolaryngology Head and Neck Surgery, The George Washington University, Washington, DC 20037, USA
    J Voice 16:117-23. 2002
    ..012) than successive bilateral injections to produce the same or longer duration of benefit. We conclude that a unilateral injection routine has a more optimal and consistent treatment effect/side effect profile...
  35. ncbi The safety and efficacy of dose-sparing intradermal administration of influenza vaccine in human immunodeficiency virus-positive patients
    Homayoon Khanlou
    Arch Intern Med 166:1417. 2006
  36. doi Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
    Jenny D Chiu
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Diabetes 57:828-35. 2008
    ....
  37. ncbi Botox treatment in adductor spasmodic dysphonia: a meta-analysis
    Frank Boutsen
    Department of Communication Sciences and Disorders, University of Oklahoma, Norman, USA
    J Speech Lang Hear Res 45:469-81. 2002
    ..This result, together with methodological limitations and lack of standardization in BT efficacy research, justifies caution when making inferences regarding BT treatment benefit in adductor spasmodic dysphonia...
  38. ncbi A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles
    Bruno Pitard
    INSERM U533, Faculte de Medecine, 44000 Nantes, France
    Hum Gene Ther 13:1767-75. 2002
    ..We propose that the PE6400 formulation could serve for the treatment of diseases primarily affecting muscle or for the expression of therapeutic proteins for local or systemic benefit...
  39. ncbi Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review
    Juliet Manyemba
    Clinical Age Research Unit, Guy s, King s and St Thomas s School of Medicine, King s College Hospital, London
    S Afr Med J 93:212-8. 2003
    ..Giving penicillin to these people can prevent recurrent attacks of RF and subsequent rheumatic heart disease. However, there is no agreement on the most effective method of giving penicillin...
  40. pmc Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults
    Robert B Belshe
    Saint Louis University Medical Center, St Louis, MO 63110, United States
    Vaccine 25:6755-63. 2007
    ..ID route was not superior to IM vaccine at inducing antibodies. ID vaccine induced significantly more local inflammatory response than IM vaccine...
  41. ncbi Direct priming and cross-priming contribute differentially to the induction of CD8+ CTL following exposure to vaccinia virus via different routes
    Xuefei Shen
    Program in Biochemistry, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Immunol 169:4222-9. 2002
    ..c. or intradermal infection. Thus, classic MHC class I Ag presentation and cross-priming contribute differentially to the induction of CD8(+) CTLs following exposure to vaccinia virus via different routes...
  42. ncbi A review of the safety and efficacy of droperidol for the rapid sedation of severely agitated and violent patients
    John H Shale
    Department of Psychiatry, University of California San Diego School of Medicine, USA
    J Clin Psychiatry 64:500-5. 2003
    ..However, several recent articles have suggested that droperidol may have a quinidine-like effect similar to that of thioridazine in inducing dysrhythmia...
  43. pmc Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus
    David Favre
    INSERM ERM 0105, Ecole Nationale Veterinaire, Nantes, France
    J Virol 76:11605-11. 2002
    ..In addition, our results suggest potential improvements for vector design...
  44. ncbi Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: application to interleukin 10 therapy in experimental arthritis
    Norma Perez
    Genethon, CNRS URA 1923, 91000 Evry, France
    Hum Gene Ther 13:2161-72. 2002
    ..We conclude that the use of tTS significantly improves the utility of the rtTA system for somatic gene transfer by reducing background activity...
  45. ncbi Intramuscular injections into the buttocks: are they truly intramuscular?
    V O Chan
    Department of Radiology, The Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland
    Eur J Radiol 58:480-4. 2006
    ..To radiologically determine if intramuscular (IM) injections into the buttocks are truly intramuscular...
  46. ncbi DNA vaccines, combining form of antigen and method of delivery to raise a spectrum of IFN-gamma and IL-4-producing CD4+ and CD8+ T cells
    Alp E Oran
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Immunol 171:1999-2005. 2003
    ..Studies in B cell knockout and hen egg lysozyme Ig transgenic mice revealed that B cells were required for the generation of IL-4-producing CD8(+) T cells...
  47. ncbi Recombinant OprF-OprI as a vaccine against Pseudomonas aeruginosa infections
    U Baumann
    Medizinische Hochschule Hannover, Abteilung Pädiatrische Pneumonologie und Neonatalogie, 30623 Hannover, Germany
    Vaccine 22:840-7. 2004
    ..We conclude that the newly developed vaccine may be suitable for protection of the main risk groups of P. aeruginosa infections. In particular, for the protection of burn patients and patients with cystic fibrosis...
  48. pmc Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine
    Gisele Huf
    National Institute of Quality Control in Health INCQS, Oswaldo Cruz Foundation FIOCRUZ, Av Brasil 4365, Manguinhos, 21040 900, Rio de Janeiro, Brazil
    BMJ 335:869. 2007
    ..To determine whether haloperidol alone results in swifter and safer tranquillisation and sedation than haloperidol plus promethazine...
  49. ncbi Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits
    Goro Motomura
    Kyushu University, Fukuoka, Japan
    Arthritis Rheum 50:3387-91. 2004
    ..To investigate the effects of combination treatment with an anticoagulant (warfarin) plus a lipid-lowering agent (probucol) on the prevention of steroid-induced osteonecrosis (ON) in rabbits...
  50. pmc Comparative pharmacokinetics of intramuscular artesunate and artemether in patients with severe falciparum malaria
    T T Hien
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    Antimicrob Agents Chemother 48:4234-9. 2004
    ..These findings should be formally assessed by a randomized clinical trial...
  51. ncbi Does obesity prevent the needle from reaching muscle in intramuscular injections?
    Ayten Zaybak
    Department of Basic Nursing, School of Nursing, Ege University, Izmir, Turkey
    J Adv Nurs 58:552-6. 2007
    ..measure subcutaneous tissue thickness at the dorsogluteal and ventrogluteal sites and to determine optimal needle length for dorsogluteal and ventrogluteal intramuscular injections in adults with a body mass index of more than 24.9 kg/m2.
  52. ncbi Computed tomographic measurement of gluteal subcutaneous fat thickness in reference to failure of gluteal intramuscular injections
    Brent E Burbridge
    Academic Department of Medical Imaging, University of Saskatchewan, Saskatoon, SK
    Can Assoc Radiol J 58:72-5. 2007
    ..on computed tomography (CT) of the pelvis leads to the hypothesis that, in some individuals, intended intramuscular injections are not properly deposited in the gluteal muscle...
  53. ncbi Dose sparing with intradermal injection of influenza vaccine
    Richard T Kenney
    IOMAI, Gaithersburg, MD 20878, USA
    N Engl J Med 351:2295-301. 2004
    ..The loss of half the U.S. supply of influenza vaccine due to contamination has created a critical shortage. Dose-sparing strategies that use intradermal delivery of vaccines may be one approach to consider...
  54. ncbi Immunogenicity and safety of intradermal influenza immunization at a reduced dose in healthy children
    Susan S Chiu
    Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, China
    Pediatrics 119:1076-82. 2007
    ..We conducted this study to test the hypothesis that intradermal influenza vaccination at one fifth of a standard dose elicits comparable immunogenicity to full-dose intramuscular vaccination in children...
  55. pmc Rapid tranquillisation in psychiatric emergency settings in India: pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine
    Nirmal S Raveendran
    Department of Psychiatry, Christian Medical College, Vellore, Tamil Nadu, India
    BMJ 335:865. 2007
    ..To compare the effect of intramuscular olanzapine with intramuscular haloperidol plus promethazine on rapid tranquillisation of agitated or violent people with mental illness...
  56. ncbi Short needles (8 mm) reduce the risk of intramuscular injections in children with type 1 diabetes
    N Tubiana-Rufi
    Department of Pediatric Endocrinology and Diabetology, Robert Debre Hospital, Assistance Publique Hopitaux de Paris, France
    Diabetes Care 22:1621-5. 1999
    To study whether 8-mm needles can reduce the frequency of intramuscular injections in diabetic children.
  57. ncbi Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men
    E Nieschlag
    Institute of Reproductive Medicine of the University, Munster, Germany
    Clin Endocrinol (Oxf) 51:757-63. 1999
    ..To investigate the suitability of intramuscular testosterone undecanoate (TU) injections for substitution therapy in hypogonadal men...
  58. pmc Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines
    Jason B Alarcon
    BD Technologies, Research Triangle Park, NC 27709, USA
    Clin Vaccine Immunol 14:375-81. 2007
    ..Altogether, the results demonstrate that microneedle-based i.d. delivery elicits antibody responses that are at least as strong as via i.m. injection and that, in many cases, dose sparing can be achieved by this new immunization method...
  59. ncbi Early hypoglycaemia after accidental intramuscular injection of insulin glargine
    B Karges
    University Children s Hospital, 1, University of Ulm, Ulm, Germany
    Diabet Med 22:1444-5. 2005
    ..We studied a slim 24-year-old female with Type 1 diabetes who repeatedly experienced severe hypoglycaemia after switching from NPH insulin to insulin glargine at identical daily doses...
  60. ncbi Promoter- and strain-selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85
    Zhihui Yang
    Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198 5830, USA
    J Control Release 108:496-512. 2005
    ..In addition Pluronic increased the number of DNA copies and thus affected initial stages of gene transfer in a promoter selective manner...
  61. ncbi Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination
    Robert J Garmise
    School of Pharmacy, University of North Carolina at Chapel Hill, CB 7360 Kerr Hall Room 1310, Chapel Hill, NC 27599, USA
    AAPS PharmSciTech 8:E81. 2007
    ..It was concluded that enhanced serum and mucosal antibody responses were elicited by a dry powder nasal vaccine, specifically, administered in the presence of sodium alginate...
  62. ncbi Paradoxical use of frontalis muscle and the possible role of botulinum a toxin in permanent motor relearning
    Guy J Ben Simon
    Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Ophthalmology 112:918-22. 2005
    ..Successful treatment with botulinum A toxin facilitated motor relearning and cessation of muscle contraction...
  63. doi A 4-mm needle reduces the risk of intramuscular injections without increasing backflow to skin surface in lean diabetic children and adults
    Niels H Birkebaek
    Diabetes Care 31:e65. 2008
  64. ncbi Intramuscular midazolam vs intravenous diazepam for acute seizures
    Ira Shah
    Department of Pediatrics, Seth G S Medical College and KEM Hospital, Parel, Mumbai, India
    Indian J Pediatr 72:667-70. 2005
    ..To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam...
  65. doi Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model
    Niels Hagenaars
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Vaccine 26:6555-63. 2008
    ....
  66. ncbi An angled insertion technique using 6-mm needles markedly reduces the risk of intramuscular injections in children and adolescents
    P L Hofman
    Liggins Institute, University of Auckland, Auckland, New Zealand
    Diabet Med 24:1400-5. 2007
    ....
  67. ncbi Serum antibody responses after intradermal vaccination against influenza
    Robert B Belshe
    Department of Internal Medicine, Division of Infectious Diseases and Immunology, Saint Louis University, St Louis, MO 63110, USA
    N Engl J Med 351:2286-94. 2004
    ..If found to be safe and immunogenic, reduced doses of influenza vaccine given by the intradermal route could increase the number of available doses of vaccine...
  68. ncbi Angiogenesis and white blood cell proliferation induced in mice by injection of a prolactin-expressing plasmid into muscle
    Ji Yun Ko
    School of Life Science, The Catholic University of Korea, Puchon 420 743, Korea
    Mol Cells 15:262-70. 2003
    ..They also indicate that direct intramuscular injection of naked DNA can be used effectively to study the function of secreted proteins, including endocrine signaling molecules...
  69. ncbi The kinetics of routine antenatal prophylactic intramuscular injections of polyclonal anti-D immunoglobulin
    I Z MacKenzie
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK
    BJOG 113:97-101. 2006
    ..To observe the pharmacokinetics of intramuscular anti-D immunoglobulin (IgG) given for routine antenatal prophylaxis...
  70. ncbi Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system
    V Salucci
    IRBM P Angeletti, Rome, Italy
    Gene Ther 9:1415-21. 2002
    ..The results allow us to draw some general conclusions about the combination of transcription regulators and their relative orientation to the transgene to achieve maximal induction, while minimizing leakiness of expression...
  71. doi Safety, tolerability, pharmacokinetics, and immunogenicity of motavizumab, a humanized, enhanced-potency monoclonal antibody for the prevention of respiratory syncytial virus infection in at-risk children
    Katia Abarca
    Hospital Clínico Pontificia Universidad Católica de Chile, Santiago, Chile
    Pediatr Infect Dis J 28:267-72. 2009
    ..Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children. Motavizumab is an investigational humanized monoclonal antibody for RSV prophylaxis...
  72. ncbi An experimental study on the use of manual pressure to reduce pain in intramuscular injections
    Joanne W Y Chung
    School of Nursing, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    J Clin Nurs 11:457-61. 2002
    ..They were required to receive two doses of vaccines via intramuscular injections. One was given in a conventional way, i.e...
  73. pmc A dose-response evaluation of inactivated influenza vaccine given intranasally and intramuscularly to healthy young adults
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States
    Vaccine 25:5367-73. 2007
    ..Nasal IgA antibody responses were more common when vaccine was administered IN; and, when the IN dosage was increased, the primary benefit from IN vaccine over IM vaccine appeared to be greater induction of nasal secretory antibody...
  74. pmc Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of mechanism
    David P McDonnell
    Lilly Research Laboratories, Indianapolis, Indiana, USA
    BMC Psychiatry 10:45. 2010
    ..The authors conducted a series of parallel investigations into the possible reasons PDSS events occur...
  75. ncbi Quality of life of patients undergoing ovarian stimulation with injectable drugs in relation to medical practice in France
    Eric Sedbon
    Reprod Biomed Online 12:298-303. 2006
    ..Clear information is necessary to increase patient's compliance to the treatment. Simplification will make these procedures more patient-friendly and less of a struggle...
  76. ncbi Some pharmacokinetic data for danofloxacin in healthy goats
    M Atef
    Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Egypt
    Vet Res Commun 25:367-77. 2001
    ..The systemic bioavailability after IM injection was 65.70% +/- 10.28% and the serum protein-bound fraction was 13.55 +/- 1.78%...
  77. ncbi Pharmacokinetics of marbofloxacin in lactating cows after repeated intramuscular administrations and pharmacodynamics against mastitis isolated strains
    M Schneider
    Vétoquinol, R and D Department, B P 189, 70204 Lure, France
    J Dairy Sci 87:202-11. 2004
    ..Hence, a possible efficacy of marbofloxacin in the treatment of E. coli-induced mastitis could be expected as the endpoints of 10 and 250 h, respectively, are reached...
  78. ncbi Systemic methotrexate therapy versus laparoscopic salpingostomy in patients with tubal pregnancy. Part I. Impact on patients' health-related quality of life
    P T Nieuwkerk
    Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, The Netherlands
    Fertil Steril 70:511-7. 1998
    ..To compare patients' health-related quality of life after systemic methotrexate therapy versus laparoscopic salpingostomy for tubal pregnancy...
  79. ncbi The disposition of intramuscular artemether in children with cerebral malaria; a preliminary study
    S A Murphy
    Kenya Medical Research Institute, Clinical Research Centre, Kilifi Unit, Kenya
    Trans R Soc Trop Med Hyg 91:331-4. 1997
    ..013). We conclude that the bioavailability of intramuscular AM in children with severe malaria may be highly variable, particularly in the presence of respiratory distress, and may be associated with an inadequate therapeutic response...
  80. ncbi Prehospital sedation with intramuscular droperidol: a one-year pilot
    J L Hick
    Department of Emergency Medicine, University of Minnesota, Hennepin County Medical Center, Minneapolis 55415, USA
    Prehosp Emerg Care 5:391-4. 2001
    ..Droperidol is an antipsychotic and sedative agent that might be effectively utilized by paramedics to assist in the management of uncontrollably violent patients...
  81. pmc The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria
    Kenneth F Ilett
    Department of Pharmacology, University of Western Australia, Nedlands 6009 Western Australia
    Br J Clin Pharmacol 53:23-30. 2002
    ..To obtain pharmacokinetic data for artesunate (ARTS) and its active metabolite dihydroartemisinin (DHA) following i.m. ARTS and rectal DHA administration...
  82. ncbi Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study
    J Crawley
    Kenya Medical Research Institute Wellcome Trust Centre for Geographic Medicine Research Coast, Kilifi
    Lancet 355:701-6. 2000
    ..We undertook a randomised study to assess the efficacy of intramuscular phenobarbital in preventing seizures in childhood cerebral malaria...
  83. ncbi Severe amphethamine-induced bruxism: treatment with botulinum toxin
    S J See
    Department of Neurology, Singapore General Hospital, Singapore
    Acta Neurol Scand 107:161-3. 2003
    ..However, there is little information on its use in tardive bruxism. Here we report an amphetamine addict who presented with medically intractable bruxism, and discuss its pathophysiology and successful treatment with BTX...
  84. pmc Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria
    Claire Nealon
    Department of Infectious Diseases, St George s Hospital Medical School, London SW17 ORE, United Kingdom
    Antimicrob Agents Chemother 46:3933-9. 2002
    ..001 to 1.58 liters/kg/min). There were no major adverse events attributable to ARS. Parasite clearance kinetics were comparable between the two treatment groups. These results support the use of i.m. ARS in children with severe malaria...
  85. ncbi Does botulinum toxin improve the function of the patient with spasticity after stroke?
    Eduardo Cardoso
    Division of Neurology and Epidemiology, Federal University of Bahia, Salvador, BA, Brazil
    Arq Neuropsiquiatr 65:592-5. 2007
    ..Although several papers have shown that intramuscular injections of botulinum toxin type A (BT-A) decreases spasticity in post-stroke patients, few authors have ..
  86. ncbi Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: results from a randomized double-blind placebo-controlled multicentre study
    Hartmut Gobel
    Kiel Pain Centre, Heikendorfer Weg 9 27, 24149 Kiel, Germany
    Pain 125:82-8. 2006
    ..Injections were well tolerated...
  87. ncbi Potentiation of botulinum toxin type A with oral anti-spasticity medications in the management of focal spasticity
    Alper Dai
    J Rehabil Med 39:189; author reply 189. 2007
  88. ncbi A double-blind, controlled study of botulinum toxin A in chronic myofascial pain
    Bruce A Richards
    Neurology 68:963; author reply 963-4. 2007
  89. pmc Botulinum toxin type-A therapy in cluster headache: an open study
    Petra Sostak
    Department of Neurology, Klinikum Groshadern, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    J Headache Pain 8:236-41. 2007
    ..Patients with episodic CH did not benefit from BTX-A treatment. Tolerability was excellent. These findings provide evidence that BTX-A may be beneficial as an add-on prophylactic therapy for a limited number of patients with chronic CH...
  90. ncbi Nurses' role in management and treatment of dystonia
    Shirley A Grant
    Ninewells Hospital, Dundee
    Nurs Times 101:50-1. 2005
    ..It is often accompanied by chronic pain. Specialist nurses now treat and support many patients...
  91. ncbi Botulinum toxin type A for upper limb spasticity following stroke: an open-label study with individualised, flexible injection regimens
    J Slawek
    Department of Neurosurgery, Division of Movement Disorders and Functional Neurosurgery, Medical University, ul Debinki 7, 80 211, Gdansk, Poland
    Neurol Sci 26:32-9. 2005
    ..Individualised BTX-A injection regimens may be an effective, reversible and safe new treatment option for patients with spasticity. Nevertheless, functional improvement may be reached only in selected patients...
  92. ncbi Trigonal injection of botulinum toxin-A does not cause vesicoureteral reflux in neurogenic patients
    Frederico Mascarenhas
    Department of Urology, Hospital Santo Antonio das Obras Sociais Irmã Dulce, Bahia, Brazil
    Neurourol Urodyn 27:311-4. 2008
    ..We evaluated the effect of botulinum toxin type A (BTX-A) injections in the trigone on the antireflux mechanism and evaluated its short-term efficacy...
  93. ncbi Cost-effectiveness of botulinum toxin type a in the treatment of post-stroke spasticity
    Anthony Ward
    North Staffordshire Rehabilitation Unit, The Hayward, Stoke on Trent, Staffordshire, UK
    J Rehabil Med 37:252-7. 2005
    ..The objective of this study was to compare the cost-effectiveness and outcomes of oral therapy vs. botulinum toxin type A treatment strategies in patients with flexed wrist/clenched fist spasticity...
  94. ncbi Botulinum toxin A improves the quality of life of patients with neurogenic urinary incontinence
    Brigitte Schurch
    Spinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland
    Eur Urol 52:850-8. 2007
    ..To evaluate the impact of botulinum toxin type A (BoNTA) on health-related quality of life in patients with neurogenic urinary incontinence (UI) using the Incontinence Quality of Life questionnaire (I-QOL)...
  95. ncbi Repeated botulinum toxin injections can improve mobility in patients with spinal cord lesions
    A Catz
    Spinal Department and Research Laboratory, Loewenstein Rehabilitation Hospital, Raanana, Israel
    Eura Medicophys 43:319-25. 2007
    ....
  96. ncbi Relationship of botulinum dosage to duration of side effects and normal voice in adductor spasmodic dysphonia
    Christopher Y Chang
    Fauquier Ear, Nose, and Throat Consultants, PLC, Warrenton, VA 20186, USA
    Otolaryngol Head Neck Surg 136:894-9. 2007
    ..From this information, to provide a rational guide to determine the initial and follow-up BTX-A amounts for injection...
  97. ncbi A randomised, double-blind, dose-ranging study to evaluate efficacy and safety of three doses of botulinum toxin type A (Botox) for the treatment of spastic foot
    F Mancini
    Parkinson s Disease and Movement Disorders Center, IRCCS C Mondino Institute of Neurology, Via Mondino 2, I 27100, Pavia, Italy
    Neurol Sci 26:26-31. 2005
    ..In particular, the medium BTX dosages (320 UI spread over 2-5 muscles) were found to be both safe and effective in producing long-lasting improvement of spastic foot dysfunction...
  98. ncbi Botulinum toxin A injection under electromyographic guidance for treatment of spasmodic dysphonia
    P Casserly
    Department of Otolaryngology, Head and Neck Surgery, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    J Laryngol Otol 122:52-6. 2008
    ..We demonstrate that the electromyography signal is a reliable prognostic indicator in terms of efficacy, and that patients' subjective opinion is a valid indicator of treatment success and future treatment strategy...
  99. ncbi The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson's disease: a double blind placebo-controlled pilot study
    Tanya Gurevich
    Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 22:880-3. 2007
    ..To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients...
  100. ncbi Functional outcome of botulinum toxin injection of gastrocnemius and adductors in spastic hemiplegic cerebral palsied children
    A I Ibrahim
    Unit of Physical Therapy, Faculty of Rehabilitation Sciences, University of Jordan, Amman, Jordan
    Eura Medicophys 43:13-20. 2007
    ..The aim of this paper was to compare between the various effects of botulinum toxin type A (BT-A) when it is injected at gastrocnemius or adductors or at both sites in ambulant spastic hemiplegic cerebral palsy (CP) children...
  101. ncbi Can the ice-water test predict the outcome of intradetrusor injections of botulinum toxin in patients with neurogenic bladder dysfunction?
    Mirjam Huwyler
    Neuro Urology, Swiss Paraplegic Center, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland
    World J Urol 25:613-7. 2007
    ..17 and -0.2, respectively. Based on our population the ice-water test cannot predict the efficacy of intradetrusor botulinum toxin injections in patients with neurogenic detrusor overactivity...

Research Grants74

  1. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2010
    ..compound, named CBLB502, is a powerful radioprotectant and mitigator of radiation injury suitable for intramuscular injections. It is a polypeptide derived from bacterial protein flagellin that acts as an agonist of Toll-like ..
  2. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - DCC
    ELIZABETH ANN THOM; Fiscal Year: 2010
    ..Eligible and consenting women will be randomized to a course of two intramuscular injections containing 12 mg of betamethasone, 24 hours apart or to a similar course of an identically appearing ..
  3. Oral Testosterone for Male Hormonal Contraception
    John K Amory; Fiscal Year: 2011
    ..Current methods of testosterone delivery include intramuscular injections, implants, or a daily transdermal patch or gel, since oral administration of testosterone (in contrast to ..
  4. Controlling Radiation Injury by TLR5 Agonists
    Andrei Gudkov; Fiscal Year: 2009
    ..compound, named CBLB502, is a powerful radioprotectant and mitigator of radiation injury suitable for intramuscular injections. It is a polypeptide derived from bacterial protein flagellin that acts as an agonist of Toll-like ..
  5. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ..Drugs will be administered under double-blind conditions in capsules, oral solutions, or intramuscular injections. The effects of drug administration will be assessed using various subjective, psychomotor performance, ..
  6. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2006
    ..Drugs will be administered under double-blind conditions in capsules, oral solutions, or intramuscular injections. The effects of drug administration will be assessed using various subjective, psychomotor performance, ..
  7. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2003
    ..Drugs will be administered under double-blind conditions in capsules, oral solutions, or intramuscular injections. The effects of drug administration will be assessed using various subjective, psychomotor performance, ..
  8. DERMALLY APPLIED T GEL PREPARATION IN HYPOGONADAL MALES
    Thomas Weber; Fiscal Year: 2001
    ..Methods: Previous studies have shown cutaneous patches to be a superior delivery system compared to intramuscular injections of testosterone...
  9. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2004
    ..Drugs will be administered under double-blind conditions in capsules, oral solutions, or intramuscular injections. The effects of drug administration will be assessed using various subjective, psychomotor performance, ..
  10. DERMALLY APPLIED T GEL PREPARATION IN HYPOGONADAL MALES
    Thomas Weber; Fiscal Year: 1999
    ..Methods: Previous studies have shown cutaneous patches to be a superior delivery system compared to intramuscular injections of testosterone...
  11. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2005
    ..Drugs will be administered under double-blind conditions in capsules, oral solutions, or intramuscular injections. The effects of drug administration will be assessed using various subjective, psychomotor performance, ..
  12. DERMALLY APPLIED T GEL PREPARATION IN HYPOGONADAL MALES
    Thomas Weber; Fiscal Year: 2000
    ..Methods: Previous studies have shown cutaneous patches to be a superior delivery system compared to intramuscular injections of testosterone...
  13. GM2 Gangliosidosis Therapy Using Neurotropic Enzyme
    Kostantin Dobrenis; Fiscal Year: 2010
    ..cultures from a mouse model of GM2 gangliosidosis, and for retrograde transport from the periphery using intramuscular injections. The best candidate construct(s) will then be tested on disease mice using: ERT initiated at birth;HSCRT, ..
  14. GM2 Gangliosidosis Therapy Using Neurotropic Enzyme
    Kostantin Dobrenis; Fiscal Year: 2009
    ..cultures from a mouse model of GM2 gangliosidosis, and for retrograde transport from the periphery using intramuscular injections. The best candidate construct(s) will then be tested on disease mice using: ERT initiated at birth;HSCRT, ..
  15. DERMALLY APPLIED T GEL PREPARATION IN HYPOGONADAL MALES
    Thomas Weber; Fiscal Year: 2000
    ..Previous studies have shown cutaneous patches to be a superior delivery system compared to intramuscular injections of testosterone...
  16. Efficacy and Safety of AAV Gene Transfer for Hemophilia
    VALDER ARRUDA; Fiscal Year: 2002
    ..gene transfer, namely how to achieve transduction of large numbers of cells without Innumerable intramuscular injections. We hypothesize that we can achieve more extensive delivery to skeletal muscle tissue through the use of ..
  17. Efficacy and Safety of AAV Gene Transfer for Hemophilia
    VALDER ARRUDA; Fiscal Year: 2003
    ..gene transfer, namely how to achieve transduction of large numbers of cells without Innumerable intramuscular injections. We hypothesize that we can achieve more extensive delivery to skeletal muscle tissue through the use of ..
  18. Efficacy and Safety of AAV Gene Transfer for Hemophilia
    VALDER ARRUDA; Fiscal Year: 2004
    ..gene transfer, namely how to achieve transduction of large numbers of cells without Innumerable intramuscular injections. We hypothesize that we can achieve more extensive delivery to skeletal muscle tissue through the use of ..
  19. HPV Vaccine Therapy /Correlates in Head/Neck carcinoma
    Maura Gillison; Fiscal Year: 2002
    ..Sequential phase I and II clinical trials of repeated intramuscular injections of the E7(detox)HSP70 DNA vaccine are proposed in patients with HPV 16-positive oropharyngeal squamous ..
  20. Intravascular Delivery of AAV to Skeletal Muscle
    VALDER ARRUDA; Fiscal Year: 2005
    ..techniques that allow transduction of large numbers of muscle fibers without requiring hundreds of intramuscular injections. Skeletal muscle contains a rich network of capillaries that can be chemically and/or mechanically ..
  21. TNT: Targeting and Triggering Adjuvancy of DNA Vaccines
    Michele Kutzler; Fiscal Year: 2004
    ..Several HIV-1 Gag DNA immunization strategies including adjuvant combinations with simultaneous intramuscular injections, sequential prime/boost regime, or alternative immunization timing schedules will be examined...
  22. TNT: Targeting and Triggering Adjuvancy of DNA Vaccines
    Michele Kutzler; Fiscal Year: 2003
    ..Several HIV-1 Gag DNA immunization strategies including adjuvant combinations with simultaneous intramuscular injections, sequential prime/boost regime, or alternative immunization timing schedules will be examined...
  23. TNT: Targeting and Triggering Adjuvancy of DNA Vaccines
    Michele Kutzler; Fiscal Year: 2005
    ..Several HIV-1 Gag DNA immunization strategies including adjuvant combinations with simultaneous intramuscular injections, sequential prime/boost regime, or alternative immunization timing schedules will be examined...
  24. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2005
    ..Repeated intramuscular injections of acid into one gastrocnemius muscle is a unique model since there is bilateral mechanical hyperalgesia ..
  25. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2006
    ..Repeated intramuscular injections of acid into one gastrocnemius muscle is a unique model since there is bilateral mechanical hyperalgesia ..
  26. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..Repeated intramuscular injections of acid into one gastrocnemius muscle is a unique model since there is bilateral mechanical hyperalgesia ..
  27. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
    ..Repeated intramuscular injections of acid into one gastrocnemius muscle is a unique model since there is bilateral mechanical hyperalgesia ..
  28. GENEVAX HIV, CANDIDATE DNA VACCINE SAFETY, TOLERABILITY AND IMMUNOGENEITY
    Rob MacGregor; Fiscal Year: 2000
    ..Subjects with CD4 cell counts >400 and RNA copy number (viral load :VL:)) >1,000/mi are given 3 intramuscular injections at 4 week intervals with a booster at 24 weeks; subjects are randomized 5:2 to receive vaccine: diluent...
  29. GENEVAX HIV, CANDIDATE DNA VACCINE SAFETY, TOLERABILITY AND IMMUNOGENEITY
    Rob MacGregor; Fiscal Year: 1999
    ..Subjects with CD4 cell counts >400 and RNA copy number (viral load :VL:)) >1,000/mi are given 3 intramuscular injections at 4 week intervals with a booster at 24 weeks; subjects are randomized 5:2 to receive vaccine:diluent...
  30. Factor IX tolerance in hemophilia gene therapy
    Hengjun Chao; Fiscal Year: 2007
    ..The applicants recently reported that direct intramuscular injections of AAV serotype one vectors (AAV1) effected sustained and complete hemophilia B phenotype correction ..
  31. Neuronal Modulation of Focal Bone Homeostasis
    Ted S Gross; Fiscal Year: 2010
    ..vivo murine model of transient muscle paralysis that inhibits both motor and sensory signaling following intramuscular injections of botulinum toxin A (BTxA)...
  32. FIX tolerance in hemophilia gene therapy
    Hengjun Chao; Fiscal Year: 2005
    ..The applicants recently reported that direct intramuscular injections of AAV serotype one vectors (AAV1) effected sustained and complete hemophilia B phenotype correction ..
  33. FIX tolerance in hemophilia gene therapy
    Hengjun Chao; Fiscal Year: 2006
    ..The applicants recently reported that direct intramuscular injections of AAV serotype one vectors (AAV1) effected sustained and complete hemophilia B phenotype correction ..
  34. FIX tolerance in hemophilia gene therapy
    Hengjun Chao; Fiscal Year: 2004
    ..The applicants recently reported that direct intramuscular injections of AAV serotype one vectors (AAV1) effected sustained and complete hemophilia B phenotype correction ..
  35. Promoting regeneration in muscular dystrophy with adipose derived stem cells.
    Gretchen A Meyer; Fiscal Year: 2012
    ..FAP phenotype to become and remain myogenic even in the face of adipogenic cues;and (Aim 2) to perform intramuscular injections of ASC-derived myotubes in dystrophic muscle with faty infiltration and ases engraftment, dystrophin ..
  36. NEURAL MECHANISMS OF MUSCLE PAIN
    DONALD SIMONE; Fiscal Year: 1993
    ..activity and responses to quantitative mechanical stimulation of muscle will be obtained before and after intramuscular injections of vehicle and capsaicin...
  37. FERTILITY TRIAL OF HT CAST IN FEMALE CYNOMOLGUS MACAQUES
    Bill Lasley; Fiscal Year: 1999
    ..Each treatment will consist of two intramuscular injections in each animals' outer thighs...
  38. 'AUTOIMMUNE' THROMBOCYTOPENIA
    Nazareth Gengozian; Fiscal Year: 1980
    ..variables since platelets suspended in saline and inoculated intravenously are without effect while intramuscular injections frequently lead to the disease syndrome...
  39. HEROIN & ITS METABOLITES PARTIALLY MIMIC EFFECTS OF COCAINE
    JAMES ROWLETT; Fiscal Year: 2001
    ..active metabolites 6-monoacetylmorphine (6-MAM) and morphine in squirrel monkeys trained to discriminate intramuscular injections of cocaine from saline Under test conditions, cocaine engendered dose-related increases in drug-lever ..
  40. COCAINE LIKE EFFECTS OF HEROIN: ACTIVE METABOLITES & OPIOID RECEPTOR MECHANISMS
    JAMES ROWLETT; Fiscal Year: 2000
    ..active metabolites 6-monoacetylmorphine (6-MAM) and morphine in squirrel monkeys trained to discriminate intramuscular injections of cocaine from saline Under test conditions, cocaine engendered dose-related increases in drug-lever ..
  41. HEROIN & ITS METABOLITES PARTIALLY MIMIC EFFECTS OF COCAINE
    JAMES ROWLETT; Fiscal Year: 2002
    ..active metabolites 6-monoacetylmorphine (6-MAM) and morphine in squirrel monkeys trained to discriminate intramuscular injections of cocaine from saline Under test conditions, cocaine engendered dose-related increases in drug-lever ..
  42. HEROIN & ITS METABOLITES PARTIALLY MIMIC EFFECTS OF COCAINE
    JAMES ROWLETT; Fiscal Year: 1999
    ..active metabolites 6-monoacetylmorphine (6-MAM) and morphine in squirrel monkeys trained to discriminate intramuscular injections of cocaine from saline Under test conditions, cocaine engendered dose-related increases in drug-lever ..
  43. Peripheral Receptor Mechanisms in Orofacial Muscle Pain
    JIN RO; Fiscal Year: 2009
    ..differentially affect neuronal activation in the Vc under an experimental myositis condition, (2) Intramuscular injections with glutamate will induce central sensitization ofVc neurons and antagonizing peripheral EAA receptors-..
  44. Peripheral Receptor Mechanisms in Orofacial Muscle Pain
    JIN RO; Fiscal Year: 2006
    ..differentially affect neuronal activation in the Vc under an experimental myositis condition, (2) Intramuscular injections with glutamate will induce central sensitization ofVc neurons and antagonizing peripheral EAA receptors-..
  45. Peripheral Receptor Mechanisms in Orofacial Muscle Pain
    JIN RO; Fiscal Year: 2007
    ..differentially affect neuronal activation in the Vc under an experimental myositis condition, (2) Intramuscular injections with glutamate will induce central sensitization ofVc neurons and antagonizing peripheral EAA receptors-..
  46. Peripheral Receptor Mechanisms in Orofacial Muscle Pain
    JIN RO; Fiscal Year: 2005
    ..differentially affect neuronal activation in the Vc under an experimental myositis condition, (2) Intramuscular injections with glutamate will induce central sensitization ofVc neurons and antagonizing peripheral EAA receptors-..
  47. Cyclic Testosterone on muscle function in older men
    Randall Urban; Fiscal Year: 2007
    ..Weekly testosterone enanthate (TE) or placebo intramuscular injections will be given for 5 months to older men in three groups, (1) monthly on/off intervals, (2) continuously, ..
  48. Cyclic Testosterone on muscle function in older men
    Randall Urban; Fiscal Year: 2006
    ..Weekly testosterone enanthate (TE) or placebo intramuscular injections will be given for 5 months to older men in three groups, (1) monthly on/off intervals, (2) continuously, ..
  49. Cyclic Testosterone on muscle function in older men
    Randall Urban; Fiscal Year: 2005
    ..Weekly testosterone enanthate (TE) or placebo intramuscular injections will be given for 5 months to older men in three groups, (1) monthly on/off intervals, (2) continuously, ..
  50. Cyclic Testosterone on muscle function in older men
    Randall Urban; Fiscal Year: 2004
    ..Weekly testosterone enanthate (TE) or placebo intramuscular injections will be given for 5 months to older men in three groups, (1) monthly on/off intervals, (2) continuously, ..
  51. Cyclic Testosterone on muscle function in older men
    Randall Urban; Fiscal Year: 2009
    ..Weekly testosterone enanthate (TE) or placebo intramuscular injections will be given for 5 months to older men in three groups, (1) monthly on/off intervals, (2) continuously, ..
  52. MYOBLAST IMPLANTATION IN SKELETAL AND CARDIAC MUSCLE
    Ann Neumeyer; Fiscal Year: 1993
    ..of implanting genetically labelled L6 myoblasts into skeletal muscle using both intra-arterial and intramuscular injections. Moreover, pilot preliminary data suggests the same cells may be implanted into ischemic rat heart muscle...
  53. TESTOSTERONE REPLACEMENT THERAPY IN HIV-POSITIVE MEN
    Judith Rabkin; Fiscal Year: 1993
    ..Treatment has two phases. The first consists of open treatment for 12 weeks with biweekly intramuscular injections of depot testosterone ester, with serum levels assessed one week after each injection...
  54. AVONEX IN TREATMENT OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
    Jerry Wolinsky; Fiscal Year: 1999
    ..The primary objective of this trial is to determine if weekly intramuscular injections of recombinant interferon beta-1a (Avonex) is effective in slowing the progression of secondary ..
  55. AVONEX IN TREATMENT OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
    Jerry Wolinsky; Fiscal Year: 2000
    ..The primary objective of this trial is to determine if weekly intramuscular injections of recombinant interferon beta-1a (Avonex) is effective in slowing the progression of secondary ..
  56. BEHAVIORAL MEDICINE APPROACHES TO PEDIATRIC ACUTE PAIN
    KEITH SLIFER; Fiscal Year: 1999
    ..g. venipuncture, infusaport sticks, subcutaneous or intramuscular injections)...
  57. BEHAVIORAL MEDICINE APPROACHES TO PEDIATRIC ACUTE PAIN
    KEITH SLIFER; Fiscal Year: 2000
    ..g. venipuncture, infusaport sticks, subcutaneous or intramuscular injections)...
  58. Therapeutic angiogenesis to treat ischemic disorders
    Keith Webster; Fiscal Year: 2001
    ..b>Intramuscular injections or intracoronary infusions of naked and adenoviral DNA, have been shown to induce angiogenesis, stimulate ..
  59. Therapeutic angiogenesis to treat ischemic disorders
    Keith Webster; Fiscal Year: 2002
    ..b>Intramuscular injections or intracoronary infusions of naked and adenoviral DNA, have been shown to induce angiogenesis, stimulate ..
  60. CEREBRAL FLUID STUDIES IN RAPID ONSET DYSTONIA PARKINSONISM
    Allison Brashear; Fiscal Year: 1999
    The purpose of this research study is to evaluate the safety, efficacy, and dosing of intramuscular injections of Botox Purified Neurotoxin Complex in the treatment of arm spasticity in post-stroke subjects...
  61. CEREBRAL FLUID STUDIES IN RAPID ONSET DYSTONIA PARKINSONISM
    Allison Brashear; Fiscal Year: 1999
    The purpose of this research study is to evaluate the safety, efficacy, and dosing of intramuscular injections of Botox Purified Neurotoxin Complex in the treatment of arm spasticity in post-stroke subjects...
  62. MENOPAUSAL TRANSITION USING AGED MACAQUE
    Bill Lasley; Fiscal Year: 1999
    ..In order to complete the hormone intervention phases of the study, a dose response using intramuscular injections of estradiol cypionate at 5, 10 and 20 5g/ml were administered to three macaques selected from the group ..
  63. ANGIOSTATIC FUNCTION OF HUMAN 16K PROLACTIN
    Nira Ben Jonathan; Fiscal Year: 2000
    ..using three alternative delivery methods: daily injections of recombinant 16K PRL, gene transfer via intramuscular injections of 16K hPRL plasmid, or implantation of 16K PRL-expressing COS cells encapsulated in hollow fibers...
  64. ALVAC-CEA-B7 VACCINE TREATMENT OF ADVANCED CEA EXPRESSING ADENOCARCINOMAS
    Howard Kaufman; Fiscal Year: 1999
    ..Increasing doses of virus will be used in patients with advanced CEA-expressing tumors by monthly intramuscular injections over 3 months...
  65. ALVAC-CEA-B7 VACCINE TREATMENT OF ADVANCED CEA EXPRESSING ADENOCARCINOMAS
    Howard Kaufman; Fiscal Year: 2001
    ..Increasing doses of virus will be used in patients with advanced CEA-expressing tumors by monthly intramuscular injections over 3 months...
  66. Dosing interval of intranasal vitamin B12 in children
    Jeffrey Rudolph; Fiscal Year: 2000
    ..ileum resections require vitamin B12 supplementation via an alternative route, particularly in monthly intramuscular injections, to prevent deficiency of this essential nutrient...
  67. ALVAC-CEA-B7 VACCINE TREATMENT OF ADVANCED CEA EXPRESSING ADENOCARCINOMAS
    Howard Kaufman; Fiscal Year: 2000
    ..Increasing doses of virus will be used in patients with advanced CEA-expressing tumors by monthly intramuscular injections over 3 months...
  68. BENEFITS OF TESTOSTERONE ON STRENGTH IN ELDERLY MEN
    Laurence Katznelson; Fiscal Year: 2002
    ..be randomized in a double blind, placebo controlled fashion to receive testosterone enanthate therapy as intramuscular injections at a dose of 200 mg given every 2 weeks versus placebo for a total of 12 weeks...
  69. BENEFITS OF TESTOSTERONE ON STRENGTH IN ELDERLY MEN
    Laurence Katznelson; Fiscal Year: 1999
    ..be randomized in a double blind, placebo controlled fashion to receive testosterone enanthate therapy as intramuscular injections at a dose of 200 mg given every 2 weeks versus placebo for a total of 12 weeks...
  70. BENEFITS OF TESTOSTERONE ON STRENGTH IN ELDERLY MEN
    Laurence Katznelson; Fiscal Year: 2001
    ..be randomized in a double blind, placebo controlled fashion to receive testosterone enanthate therapy as intramuscular injections at a dose of 200 mg given every 2 weeks versus placebo for a total of 12 weeks...
  71. BENEFITS OF TESTOSTERONE ON STRENGTH IN ELDERLY MEN
    Laurence Katznelson; Fiscal Year: 2000
    ..be randomized in a double blind, placebo controlled fashion to receive testosterone enanthate therapy as intramuscular injections at a dose of 200 mg given every 2 weeks versus placebo for a total of 12 weeks...
  72. Delivery of human muscle SP cells to dystrophic muscle
    Emanuela Gussoni; Fiscal Year: 2004
    ..Perform intramuscular injections into NOD/RAG1/null-DMD/mdx5cv mice using the fetal and adult-derived human muscle SP and MP cell ..
  73. Delivery of human muscle SP cells to dystrophic muscle
    Emanuela Gussoni; Fiscal Year: 2006
    ..Perform intramuscular injections into NOD/RAG1/null-DMD/mdx5cv mice using the fetal and adult-derived human muscle SP and MP cell ..