intra articular injections

..Future trials of OA that examine a local therapy might need to consider restricting the study population to those patients having OA of only the signal joint...

..This was supported by findings of a survey of 66 patients at 2 years after treatment in this study. Level I prospective, randomised controlled double-blind study...

..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...

..There are no systematic reviews of corticosteroids for shoulder pain that calculate the numbers needed to treat...

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..To determine efficacy and safety of intraarticular (IA) hyaluronic acid (HA; Hyalgan) versus placebo and a nonsteroidal antiinflammatory drug for osteoarthritis (OA) of the knee...

..The development of novel drugs in combination with new formulations for IA treatment of OA, represents a promising approach in this challenging area of research...

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..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...

..We prospectively compared the short term response to randomized blind injection versus sonographic-guided injection of local corticosteroid in patients with painful shoulder...

..Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. Recent studies have suggested that periarticular infiltration with local anesthetics may improve outcome...

..We compared wound infiltration combined with intraarticular injection of local anesthetics for pain relief after total hip arthroplasty (THA) with the well-established practice of epidural infusion...

..To determine the effects of a single session of intraarticular methylprednisolone (IA-MP) injections on the function of the pituitary-adrenal axis...

..To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced arthritis in rats...

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..Predicting responders are duration of knee arthritis, CRP, and radiological scores...

..Therefore, we conclude that the use of hyaluronan may be indicated during the early stages of chondromalacia...

..Optimal treatment of carpal tunnel syndrome (CTS) has not been established. This study compared the effects of local steroid injection versus surgical decompression in new-onset CTS of at least 3 months' duration...

..DISCUSSION: This preclinical study suggests that ultrasound is a useful guiding tool for facet joint injections in the cervical spine...

..To evaluate the efficacy and the tolerability of viscosupplementation (VS) with hyaluronic acid (Hylan GF 20) in a cohort of 36 patients affected by hip osteoarthritis through a 18 months follow-up...

..Further large prospective studies are needed to determine how frequently septic arthritis of the knee is encountered post steroid injection, and the exact precautions that should be taken to avoid it...

..Viscosupplementation appears to have a slower onset of action than intra-articular steroids, but the effect seems to last longer...

..We examined the effects of nonsteroidal anti-inflammatory drug (NSAID) and intra-articular injections of sodium hyaluronate (HA) on cartilage degeneration in rabbit knee osteoarthritis (OA) model induced by partial meniscectomy...

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..8. The success rate was 50% in that subgroup. There were no complications related to the injection. CONCLUSION: Use of hylan G-F 20 injection is a viable option for treatment of mild to moderate OA of the hip joint...

..The virtual absence of serious side effects, coupled with the perceived benefits, make these approaches attractive...

..To evaluate the efficacy and tolerability of a second course of hylan G-F 20 for the treatment of osteoarthritic knee pain in patients who experienced a clinical benefit with an initial course of therapy...

..This paper will review the development, experience, indications, and clinical outcomes of viscosupplementation therapy in patients with osteoarthritis...

..This study suggests that the underlying mechanism of the anti-inflammatory effect of HA is to inhibit glutamate and aspartate release in ACLT knee joints, which attenuates the early development of OA...

..CONCLUSION: Intra-articular rAAV mediated gene therapy in RA might be improved by using rAAV5 rather than other serotypes...

..The anterolateral approach may place injected material medial to the medial bursal boundary, and fluoroscopy may not accurately assess this placement...

..These findings may reflect mechanisms controlling the transiency of clinical improvement frequently observed after IA GC injection...

..Viscosupplementation is a promising approach for hip OA, although further and wider studies are wanted to determine how long the beneficial effect lasts, and what is the optimal number of injections to administer...

..CONCLUSIONS: Repeat courses of the hyaluronans are safe and effective in the treatment of pain associated with OA of the knee...

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..5) with 95% confidence and 90% power. This would require a RCT of 104 patients to detect a 15-mm change in VAS (effect size 0.5) with 95% confidence and 90% power...

..This study assessed the accuracy of an anterior intra-articular injection in awake subjects without radiologic assistance...

..Viscosupplementation has gained popularity in the treatment of osteoarthritis of the knee. Intraarticular injections of hyaluronic acid have shown to decrease pain and improve functional outcomes...

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..These interventions have not been evaluated in managing chronic thoracic pain of facet joint origin...

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..We have therefore studied the effect of continuous injection of morphine and ropivacaine after TKR on range of movement and length of hospital stay...

..75 positive predictive value. The posterior approach had a 50% accuracy rate and a .67 positive predictive value. Anterior injections produce a higher rate of accuracy than posterior injections...

..The present observation suggests the potentiality for the safety and efficacy of hylan G-F 20 injected under US guidance in patients with symptomatic hip OA. Further controlled studies are needed...

..This systematic review of the available literature indicates that there is little reproducible evidence to support the efficacy of subacromial corticosteroid injection in managing rotator cuff disease...

..Nine asymptomatic volunteers underwent 40 provocative intra-articular injections of the thoracic zygapophyseal joints...

..The induction of osteoarthritis-like changes by intra-articular injections of collagenase in the knee joint of mature rabbits was examined...

..All these physicochemical and biologic properties of HA have been shown to be molecular weight (MW) dependent...

..The aim of this study was to assess different dosing regimens of hylan G-F 20, a high molecular-weight cross-linked derivative of HA, in the treatment of pain due to knee OA...

..This study highlights the need for clinicians to refine injection techniques for delivering intra-articular therapeutic substances that are intended to coat the articular surfaces of the knee joint...

..Short-term safety was satisfactory, with a self-limited exacerbation of pain during the first few days in three patients but no infections or other side effects...

..Assessing pain at 10 minutes for a Neer-type impingement test can fail to accurately determine a positive test in a substantial percentage of patients...

..Additionally, short-term effectiveness was confirmed...

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..To address the question whether general practitioners (GPs) should receive practical training in shoulder problems and to test whether cortisone injections are better than anaesthetic injections for rotator cuff problems...

..Current evidence suggests that viscosupplements probably provide a similar level of pain relief to glucocorticoids and do so for several months, but the onset is slower, and there is the potential for local adverse reactions...

..To investigate the numbers and types of joint and soft tissue injections performed by general practitioners (GPs) and to explore attitudes to training in joint and soft tissue injection and perceived barriers to performing injections...

..This study was designed to evaluate the efficacy and safety of intra-articular morphine, mepivacaine, or a combination of both in the management of temporomandibular joint (TMJ) pain in a 24-hour period after arthroplasty...

..The mean extension of extravasation was 15 mm. Image quality was not compromised, and no gas bubbles were detected. The procedure was successful in all patients, with no complications...

..Many of the physiological effects of exogenous HA may be a function of its molecular weight. Several physiological effects probably contribute to the mechanisms by which HA and hylans exert their clinical effects in knee OA...

..To compare the long term effectiveness of local steroid injections administered by general practitioners with practice based physiotherapy for treating patients presenting in primary care with new episodes of unilateral shoulder pain...

..The proper technique, choice and quantity of pharmaceuticals, and appropriate follow-up are essential for effective outcomes...

..We present a new method of carpal tunnel injection based on anatomic dissections. We have used this technique successfully for more than 10 years, and there have been no cases of median nerve injury...

..To compare the efficacy of a single intraarticular corticosteroid injection, a supervised physiotherapy program, a combination of the two, and placebo in the treatment of adhesive capsulitis of the shoulder...

..This study is a prospective cross-sectional analytic study...

..CONCLUSIONS: Steroids and hyaluronate injections were found effective in reducing pain. Hyaluronate was more effective in the improvement of some aspects of fine hand function...

..3% of injections. Our clinical experience shows that hylan G-F 20 effectively relieves osteoarthritis knee pain (as indicated) and reduces pain medication needed for up to 6 months with a low incidence of local adverse events...

..To investigate the effects of integrated therapy on the functional status of patients with knee osteoarthritis (OA)...

..Given these constraints, this article outlines the current alternatives available in nonoperatively managing the symptomatic unicompartmental arthritic knee...

..The risk/benefit of hylan G-F 20 in this particular population of patients is favourable...

..Although in comparison with triamcinolone its effects are achieved more slowly, the results indicate a superior long-lasting effect of hyaluronan at 6 months after end of treatment period...

..In conclusion, intra-articular Hylan G-F 20 injections not only decrease pain in patients with knee osteoarthritis, but can alter the natural history of the disease by decreasing excessive loads in the knees...

..To evaluate the efficacy and safety of injection of high molecular weight (HMW) hyaluronan (Orthovisc) in patients with mild, moderate, and severe knee osteoarthritis (OA)...

..8% solution of highly purified sodium hyaluronate for intra-articular application. The aim of the present study was to investigate the safety and tolerability profile of this preparation in patients with symptomatic knee OA over 24 weeks...

..The purpose of this study was to evaluate the efficacy of hylan G-F 20 when used to treat an active and athletic patient population with knee osteoarthritis who had undergone knee arthroscopy for mechanical symptoms...

..Intra-articular injection of an elastoviscous hyaluronan solution reduced the augmented nerve activity...

..e., cases in which a high amount of residual cartilage and chondrocyte metabolic activity remain.The biological markers were useful in predicting the effectiveness of HA injection for OA of the knee...

..To assess the efficacy and safety of intra-articular injections of sodium hyaluronate combined with a home exercise program (HEP) in the management of pain associated with osteoarthritis (OA) of the knee...

..The RPD increases physician control of the needle and is proposed to reduce patient pain during syringe procedures...

..In conclusion, intra-articular injections of HA is an effective choice of treatment in patients with knee osteoarthritis...

..Further studies are needed to evaluate their prevalence in hip OA symptomatic and not-symptomatic patients and their correlation to treatment outcome...

..To investigate the effects of intraarticular hyaluronic acid (HA) (Artzal, Seikagaku Corp., Japan) in geriatric participants with unilateral knee osteoarthritis (OA)...

..We conducted a randomized, patient- and observer-blind trial to evaluate these interventions in patients with painful knee osteoarthritis...

..To compare the efficacy and safety of intraarticular hylan and 2 hyaluronic acids (HAs) in osteoarthritis (OA) of the knee...

..These criteria focus on change in pain and physical function. The aim of this study was to reanalyse the data from the original comparative study of hylan G-F 20 and Bio-HA in knee OA utilising the new OMERACT-OARSI response criteria...

..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections...

..There was no significant difference in side-effects between the groups. In conclusion, the efficacy and safety of high and low molecular weight hyaluronate are similar...

..A method, termed the BLISS (Bellamy et al. Low Intensity Symptom State-attainment) Index, for analyzing OA knee clinical trials data, was proposed...

..As such, we conclude that only patients with a minimal to mild loss in joint space on roentgenological examination should form part of the target group who are likely to benefit from intra-articular knee viscoelastic supplementation...

..To investigate the efficacy and tolerability of a course of 5 injections of hyaluronan (HA) given at intervals of one week in patients with symptomatic, mild to moderate osteoarthritis (OA) of the knee...

..However, when data for the two hyaluronan treatments were pooled, there was a significantly longer duration of clinical benefit for hyaluronan treatment than for placebo...

..The effect was more evident in primary OA than in OA secondary to a traumatic event. This is the first evidence that local hyaluronan injections modify the structural organization of the human knee synovium in OA...

..The aim of this meta-analysis was to elucidate the therapeutic efficacy and safety of intra-articular injection of hyaluronic acid for osteoarthritis of the knee...

..In conjunction, we will develop MR molecular imaging technologies based on targeted nanoparticles to track early therapeutic responses in a rabbit model of inflammatory arthritis. ..

..2. Assess therapeutic efficacy of GIcNAc formulations in rabbits with experimentally induced OA. These studies have the potential to provide the basis for a safe and effective chondroprotective therapy for OA. ..

..An escalating dosing scheme will be used including 1,10 and 100mM GlcNAc. Patients will be monitored for local and systemic adverse reactions. ..

..In conjunction, we will develop MR molecular imaging technologies based on targeted nanoparticles to track early therapeutic responses in a rabbit model of inflammatory arthritis. ..

..3) Examine the extent of lesions in a blind fashion using morphological, histological and biochemical evaluations. ..

..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. ..

..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..

..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..

..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..

..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..

..Thus, pharmaceutical agents aimed at inhibition of ASICs are promising in that they not only have the potential to reduce the inflammatory process but also have a direct role in inhibiting musculoskeletal pain. ..

..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..

..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..

..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..

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..Emphasis will be given in evaluating COX-2 and/or mPGES-1 expression as they are targets of our FIV(siRNA) therapy over time as well as assessing potential inflammatory responses elicited by this siRNA therapy. ..

..Such information is critical to our understanding of the benefits of anti-inflammatory therapy in AD and other conditions and will guide the rational application and development of targeted interventions. ..

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..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..

..The successful completion of the project should significantly increase our understanding of the mechanism of action of an anti-oncogene and could potentially lead to a biological treatment for certain cancers...

..The successful completion of the proposed studies should determine if NF-kB inhibition in islets by peptide and gene mediated transduction is able to improve islet viability prior to and post-transplantation. ..

..The experiments described in the proposal are expected to provide important insights into the mechanism of how RB and cyclin D1 function to regulate transcription directly, cell differentiation, and tumorigenesis. ..

..This study proposes to follow individuals with rotator cuff tears and no pain over an extended period of time to determine the risk of new pain and deterioration of the cuff. ..

..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..

..The long-term goal of this project is the better understanding of higher brain functions involved in the different pain components to improve pain management strategies and decision making. ..

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..This information may lead to a better understanding of how the brain integrates pain-like signals relevant for TMD in women ..

..Subjects will be treated for 8 weeks and followed for a total of 6 months. Results of this study will direct future investigations with respect to dose effect, mechanism and optimal prescriptive parameters ..

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..If successfully completed, this study will lead to further insight to the biological effects of glucosamine on arthritis and perhaps the development of a novel chondroprotective strategy for the treatment of OA. ..

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..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..

..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..

..Finally, techniques developed for assessing central motor function may be useful for evaluating other interventions directed at stroke rehabilitation. ..

..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..

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..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..

..This will fill a gap in the literature, and provide evidence-based data for intra-articular corticosteroids, the present use of which is based only on anecdotal and conventional practices. ..

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..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..

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..In addition, this proposal will lead to important information regarding the role of neuronal plasticity in brain repair after stroke. ..

..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..

..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..