intra articular injections

Summary

Top Publications

  1. ncbi Intra-articular hyaluronic acid after knee arthroscopy: a two-year study
    Harald Hempfling
    Berufsgenossenschaftliche Unfallklinik, Prof Küntscher Strasse 8, 82418, Murnau am Staffelsee, Germany
    Knee Surg Sports Traumatol Arthrosc 15:537-46. 2007
  2. pmc Practice tips. Knee joint injections and aspirations: the triangle technique
    Leonard E Lockman
    St Vital Family Medical Clinic, Winnipeg, Manitoba, Canada
    Can Fam Physician 52:1403-4. 2006
  3. pmc Corticosteroid injections for painful shoulder: a meta-analysis
    Bruce Arroll
    Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, PB 92019, Auckland, New Zealand
    Br J Gen Pract 55:224-8. 2005
  4. doi The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 67:1716-23. 2008
  5. ncbi Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits
    T Kikuchi
    Shiseido Pharmaceutical Research Laboratories, Kanagawa, Japan
    Osteoarthritis Cartilage 6:177-86. 1998
  6. ncbi A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis
    J Song
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea
    Eur J Nucl Med 28:489-97. 2001
  7. ncbi Intraarticular drug delivery in osteoarthritis
    Nicole Gerwin
    Bone and Cartilage Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, WKL 125 13 59, CH 4002 Basel, Switzerland
    Adv Drug Deliv Rev 58:226-42. 2006
  8. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
  9. ncbi Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial
    Karen Toftdahl
    Department of Anesthesiology, Aarhus University Hospital, Denmark
    Acta Orthop 78:172-9. 2007
  10. ncbi Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors
    M J Janusz
    Procter and Gamble Pharmaceuticals, Inc, 8700 Mason Montgomery Rd, Mason, Ohio 45040 9462, USA
    Osteoarthritis Cartilage 9:751-60. 2001

Detail Information

Publications197 found, 100 shown here

  1. ncbi Intra-articular hyaluronic acid after knee arthroscopy: a two-year study
    Harald Hempfling
    Berufsgenossenschaftliche Unfallklinik, Prof Küntscher Strasse 8, 82418, Murnau am Staffelsee, Germany
    Knee Surg Sports Traumatol Arthrosc 15:537-46. 2007
    ..This was supported by findings of a survey of 66 patients at 2 years after treatment in this study. Level I prospective, randomised controlled double-blind study...
  2. pmc Practice tips. Knee joint injections and aspirations: the triangle technique
    Leonard E Lockman
    St Vital Family Medical Clinic, Winnipeg, Manitoba, Canada
    Can Fam Physician 52:1403-4. 2006
  3. pmc Corticosteroid injections for painful shoulder: a meta-analysis
    Bruce Arroll
    Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, PB 92019, Auckland, New Zealand
    Br J Gen Pract 55:224-8. 2005
    ..There are no systematic reviews of corticosteroids for shoulder pain that calculate the numbers needed to treat...
  4. doi The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 67:1716-23. 2008
    ....
  5. ncbi Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits
    T Kikuchi
    Shiseido Pharmaceutical Research Laboratories, Kanagawa, Japan
    Osteoarthritis Cartilage 6:177-86. 1998
    ..The induction of osteoarthritis-like changes by intra-articular injections of collagenase in the knee joint of mature rabbits was examined...
  6. ncbi A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis
    J Song
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea
    Eur J Nucl Med 28:489-97. 2001
    ....
  7. ncbi Intraarticular drug delivery in osteoarthritis
    Nicole Gerwin
    Bone and Cartilage Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, WKL 125 13 59, CH 4002 Basel, Switzerland
    Adv Drug Deliv Rev 58:226-42. 2006
    ..The development of novel drugs in combination with new formulations for IA treatment of OA, represents a promising approach in this challenging area of research...
  8. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
    ..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...
  9. ncbi Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial
    Karen Toftdahl
    Department of Anesthesiology, Aarhus University Hospital, Denmark
    Acta Orthop 78:172-9. 2007
    ..Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. Recent studies have suggested that periarticular infiltration with local anesthetics may improve outcome...
  10. ncbi Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors
    M J Janusz
    Procter and Gamble Pharmaceuticals, Inc, 8700 Mason Montgomery Rd, Mason, Ohio 45040 9462, USA
    Osteoarthritis Cartilage 9:751-60. 2001
    ..To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced arthritis in rats...
  11. ncbi Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysate
    Yen Hsuan Jean
    Graduate Institute of Medical Science, National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
    J Orthop Res 24:1052-61. 2006
    ..This study suggests that the underlying mechanism of the anti-inflammatory effect of HA is to inhibit glutamate and aspartate release in ACLT knee joints, which attenuates the early development of OA...
  12. ncbi Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy
    W Wenz
    Orthopaedic University Clinic Heidelberg, Germany
    J Orthop Res 18:604-12. 2000
    ..Therefore, we conclude that the use of hyaluronan may be indicated during the early stages of chondromalacia...
  13. ncbi Increases in lumbosacral injections in the Medicare population: 1994 to 2001
    Janna Friedly
    Department of Rehabilitation Medicine, University of Washington, Harborview Medical Center, Seattle, WA 98127, USA
    Spine (Phila Pa 1976) 32:1754-60. 2007
    ..Anecdotal reports and limited data suggest that the use of spinal injections is increasing, despite equivocal evidence about efficacy...
  14. ncbi Evaluation of the pituitary-adrenal axis function following single intraarticular injection of methylprednisolone
    Reuven Mader
    Ha Emek Medical Center, Afula, Israel
    Arthritis Rheum 52:924-8. 2005
    ..To determine the effects of a single session of intraarticular methylprednisolone (IA-MP) injections on the function of the pituitary-adrenal axis...
  15. ncbi Intra-articular injection of high molecular weight hyaluronan after arthrocentesis as treatment for rheumatoid knees with joint effusion
    Nobuyuki Tanaka
    Rheumatology Unit, Sapporo Gorinbashi Orthopedic Hospital in Gorinbashi Hospitals, 2 1, Kawazoe, Minami Ku, Sapporo, Hokkaido, 005 0802, Japan
    Rheumatol Int 22:151-4. 2002
    ....
  16. ncbi Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study
    Hari K Parvataneni
    Massachusetts General Hospital, Boston, Massachusetts, USA
    J Arthroplasty 22:33-8. 2007
    ..Periarticular injection with a multimodal protocol was shown to safely provide excellent pain control and functional recovery and can be substituted for conventional pain control modalities...
  17. pmc Intra-articular therapy in osteoarthritis
    I Uthman
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Postgrad Med J 79:449-53. 2003
    ..The virtual absence of serious side effects, coupled with the perceived benefits, make these approaches attractive...
  18. ncbi Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial
    Jean Pierre Raynauld
    Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 48:370-7. 2003
    ..To evaluate the safety and efficacy of long-term intraarticular (IA) steroid injections for knee pain related to osteoarthritis (OA)...
  19. ncbi Is local subacromial corticosteroid injection beneficial in subacromial impingement syndrome?
    Kenan Akgun
    Physical Medicine and Rehabilitation Department, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Clin Rheumatol 23:496-500. 2004
    ..We found that subacromial corticosteroid injections in the acute or subacute phase of SIS provided additional short-term benefit without any complication when used together with nonsteroidal anti-inflammatory drugs (NSAIDs) and exercise...
  20. ncbi The targeting accuracy of subacromial injection to the shoulder: an arthrographic evaluation
    Kotaro Yamakado
    Department of Orthopaedics, Kahoku Central Hospital, Japan
    Arthroscopy 18:887-91. 2002
    ..The study goal was to examine the targeting accuracy of subacromial injection to the shoulder and the influence of the location of the injected structure...
  21. ncbi Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group
    R D Altman
    Department of Rheumatology and Immunology, University of Miami, Florida, USA
    J Rheumatol 25:2203-12. 1998
    ..To determine efficacy and safety of intraarticular (IA) hyaluronic acid (HA; Hyalgan) versus placebo and a nonsteroidal antiinflammatory drug for osteoarthritis (OA) of the knee...
  22. ncbi Effects of intra-articular hylan G-F 20 injections on clinical and biomechanical characteristics of the knee in osteoarthritis
    Gunes Yavuzer
    Ankara University Medical School, Department of Physical Medicine and Rehabilitation, Ankara, Turkey
    Int J Rehabil Res 28:371-4. 2005
    ..In conclusion, intra-articular Hylan G-F 20 injections not only decrease pain in patients with knee osteoarthritis, but can alter the natural history of the disease by decreasing excessive loads in the knees...
  23. ncbi Viscosupplementation in symptomatic severe hip osteoarthritis: a review of the literature and report on 60 patients
    Michel P J van den Bekerom
    University Hospital Pellenberg, Leuven, Belgium
    Acta Orthop Belg 72:560-8. 2006
    ..In this article we present a literature review on the subject and report the results in 60 patients who received intraarticular viscosupplementation of the hip with the objective to delay total hip replacement surgery...
  24. ncbi Long-term effect of sodium hyaluronate (Hyalgan) on osteoarthritis progression in a rabbit model
    D Amiel
    Department of Orthopaedics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0630, USA
    Osteoarthritis Cartilage 11:636-43. 2003
    ..One of the currently available products is approved for repeat treatment courses. While HA is classed as a symptom-modifying agent, there is substantial evidence that this therapeutic modality also possesses disease-modifying activity...
  25. ncbi Intra-articular hyaluronan injections for the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled study
    E Tamir
    Department of Orthopedics, Assaf Harofe Hospital, Zerifin, Israel
    Clin Exp Rheumatol 19:265-70. 2001
    ..It appears that HA with high molecular weights (HMW) are more effective than low molecular weight HA polymers...
  26. pmc Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty
    Per Essving
    Department of Orthopedic Surgery, University of Linkoping, Sweden
    Acta Orthop 80:213-9. 2009
    ..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...
  27. ncbi Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience
    Robert J Petrella
    Department of Family Medicine, University of Western Ontario, Ontario, Canada
    Am J Phys Med Rehabil 84:278-83; quiz 284, 293. 2005
    ..Intraarticular hyaluronic acid is indicated for patients with osteoarthritis of the knee. However, clinical experience, especially efficacy and adverse events, with repeated injection series in the long term are limited...
  28. ncbi Low back pain: prediction of short-term outcome of facet joint injection with bone scintigraphy
    Spiros G Pneumaticos
    Institute of Spinal Disorders, Departments of Orthopaedic Surgery and Radiology, Baylor College of Medicine 6550 Fannin, Suite 2525, Houston, TX 77030, USA
    Radiology 238:693-8. 2006
    ..To prospectively evaluate use of bone scintigraphy with single photon emission computed tomography (SPECT) for identification of patients with low back pain who would benefit from facet joint injections...
  29. ncbi Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
    Karen V Andersen
    Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 78:180-6. 2007
    ..We compared wound infiltration combined with intraarticular injection of local anesthetics for pain relief after total hip arthroplasty (THA) with the well-established practice of epidural infusion...
  30. ncbi Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial
    Constant A Busch
    Division of Orthopaedic Surgery, London Health Sciences Centre, London, Ontario, Canada
    J Bone Joint Surg Am 88:959-63. 2006
    ..Good perioperative analgesia facilitates rehabilitation, improves patient satisfaction, and may reduce the hospital stay. We investigated the analgesic effect of locally injected drugs around a total knee prosthesis...
  31. ncbi A randomized comparative study of short term response to blind injection versus sonographic-guided injection of local corticosteroids in patients with painful shoulder
    Esperanza Naredo
    Department of Rheumatology, The Research Unit, and The Epidemiology Unit, Severo Ochoa Hospital, Madrid, Spain
    J Rheumatol 31:308-14. 2004
    ..We prospectively compared the short term response to randomized blind injection versus sonographic-guided injection of local corticosteroid in patients with painful shoulder...
  32. ncbi Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial
    Domingo Ly-Pen
    Primary Care Unit Gandhi, Madrid, Spain
    Arthritis Rheum 52:612-9. 2005
    ..Optimal treatment of carpal tunnel syndrome (CTS) has not been established. This study compared the effects of local steroid injection versus surgical decompression in new-onset CTS of at least 3 months' duration...
  33. ncbi Sonographically guided glenohumeral joint injection
    Richard B Zwar
    Department of Radiology, Austin Health, 145 163 Studley Rd, Heidelberg, Victoria 3084, Australia
    AJR Am J Roentgenol 183:48-50. 2004
  34. ncbi Evaluation of therapeutic thoracic medial branch block effectiveness in chronic thoracic pain: a prospective outcome study with minimum 1-year follow up
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Kentucky 42003, USA
    Pain Physician 9:97-105. 2006
    ..These interventions have not been evaluated in managing chronic thoracic pain of facet joint origin...
  35. ncbi Ultrasound-guided facet joint injections in the middle to lower cervical spine: a CT-controlled sonoanatomic study
    Klaus Galiano
    Clinic of Neurosurgery, Innsbruck Medical University, 6020 Innsbruck, Austria
    Clin J Pain 22:538-43. 2006
    ..The aim of this study was to investigate the efficacy of ultrasound as a guiding tool for simulated cervical facet joint injections in cadavers...
  36. pmc Hyaluronic acid injections for knee osteoarthritis. Systematic review of the literature
    Anita Aggarwal
    Department of Family Medicine, Queen s University, Kingston, Ont
    Can Fam Physician 50:249-56. 2004
    ..To determine whether viscosupplementation with intra-articular hyaluronic acid (HA) injections improves pain and function in patients with osteoarthritis (OA) in their knees...
  37. ncbi [18-month observational study on efficacy of intraarticular hyaluronic acid (Hylan G-F 20) injections under ultrasound guidance in hip osteoarthritis]
    Alberto Migliore
    U O S di Reumatologia, S Pietro Fatebenefratelli Ospedale, 00189 Roma
    Reumatismo 58:39-49. 2006
    ..To evaluate the efficacy and the tolerability of viscosupplementation (VS) with hyaluronic acid (Hylan GF 20) in a cohort of 36 patients affected by hip osteoarthritis through a 18 months follow-up...
  38. ncbi Septic arthritis following intra-articular steroid injection of the knee--a survey of current practice regarding antiseptic technique used during intra-articular steroid injection of the knee
    C P Charalambous
    Clin Rheumatol 22:386-90. 2003
    ..Further large prospective studies are needed to determine how frequently septic arthritis of the knee is encountered post steroid injection, and the exact precautions that should be taken to avoid it...
  39. ncbi An open-label study of a second course of hylan G-F 20 for the treatment of pain associated with knee osteoarthritis
    David D Waddell
    Orthopedic Specialists of Louisiana, Inc, Shreveport, LA 71103, USA
    Curr Med Res Opin 19:499-507. 2003
    ..To evaluate the efficacy and tolerability of a second course of hylan G-F 20 for the treatment of osteoarthritic knee pain in patients who experienced a clinical benefit with an initial course of therapy...
  40. ncbi Accuracy of intra-articular injection of the glenohumeral joint: a cadaveric study
    Paul M Sethi
    Orthopedic and Neurosurgical Specialists, Greenwich, Conn 06830, USA
    Orthopedics 29:149-52. 2006
    ..75 positive predictive value. The posterior approach had a 50% accuracy rate and a .67 positive predictive value. Anterior injections produce a higher rate of accuracy than posterior injections...
  41. ncbi A cost consequences analysis of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care
    M James
    Centre for Health Planning and Management, Keele University, Keele, Staffordshire ST5 5BG, UK
    Rheumatology (Oxford) 44:1447-51. 2005
    ....
  42. ncbi Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice
    Ferry Kemper
    Klinik Lohrey, Orthopädie und Rheumatologie, Bad Soden Salmünster, Germany
    Curr Med Res Opin 21:1261-9. 2005
    ..To determine the tolerability and short-term effectiveness of hylan G-F 20 (Synvisc) in patients with symptomatic osteoarthritis (OA) of the knee in standard clinical practice...
  43. ncbi [Intra-articular treatment with Hylan G-F 20 under ultrasound guidance in hip osteoarthritis. Clinical results after 12 months follow-up]
    A Migliore
    Dipartimento di Medicina Interna, Ospedale S Pietro Fatebenefratelli, Via Cassia, 600 00192 Rome
    Reumatismo 57:36-43. 2005
    ..Viscosupplementation is a promising approach for hip OA, although further and wider studies are wanted to determine how long the beneficial effect lasts, and what is the optimal number of injections to administer...
  44. ncbi Accuracy of subacromial injection: anterolateral versus posterior approach
    Peter V Mathews
    The Permanente Medical Group, Roseville, CA 95661, USA
    J Shoulder Elbow Surg 14:145-8. 2005
    ..The anterolateral approach may place injected material medial to the medial bursal boundary, and fluoroscopy may not accurately assess this placement...
  45. pmc Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy
    J Adriaansen
    Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 64:1677-84. 2005
    ..Gene therapy of the joint has great potential as a new therapeutic approach for the treatment of rheumatoid arthritis (RA). The vector chosen is of crucial importance for clinical success...
  46. ncbi Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels
    Erik af Klint
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 52:3880-9. 2005
    ..To investigate whether intraarticular (IA) glucocorticoid (GC) therapy diminishes synovial cell infiltration, vascularity, expression of proinflammatory cytokines, and adhesion molecule levels in patients with chronic arthritides...
  47. ncbi Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study
    Robert S Salk
    Northern California Foot and Ankle Center, 45 Castro Street, Suite 315, San Francisco, CA 94114, USA
    J Bone Joint Surg Am 88:295-302. 2006
    ....
  48. ncbi Intra-articular hylan G-F 20 (Synvisc) in the management of patellofemoral osteoarthritis of the knee (POAK)
    Shane Clarke
    Rheumatology Unit, University Department of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Knee 12:57-62. 2005
    ..5) with 95% confidence and 90% power. This would require a RCT of 104 patients to detect a 15-mm change in VAS (effect size 0.5) with 95% confidence and 90% power...
  49. ncbi Accuracy of anterior intra-articular injection of the glenohumeral joint
    Paul M Sethi
    Orthopedic and Neurosurgical Specialists, Greenwich, Connecticut 06830, USA
    Arthroscopy 21:77-80. 2005
    ..This study assessed the accuracy of an anterior intra-articular injection in awake subjects without radiologic assistance...
  50. ncbi Use of injections for osteoarthritis in joints and sports activity
    Jason C Snibbe
    Kerlan Jobe Orthopaedic Clinic, 6801 Park Terrace, Los Angeles, CA 90045, USA
    Clin Sports Med 24:83-91. 2005
    ..Viscosupplementation has gained popularity in the treatment of osteoarthritis of the knee. Intraarticular injections of hyaluronic acid have shown to decrease pain and improve functional outcomes...
  51. ncbi Successful nonoperative management of chronic osteoarthritis pain of the knee: safety and efficacy of retreatment with intra-articular hyaluronans
    Mark Pagnano
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Osteoarthritis Cartilage 13:751-61. 2005
    ..Five intra-articular hyaluronan products are approved in the US. No systematic review of the safety and efficacy of their chronic use has been reported...
  52. ncbi Open pilot study of ultrasound-guided intra-articular injection of hylan G-F 20 (Synvisc) in the treatment of symptomatic hip osteoarthritis
    Alberto Migliore
    Department of Internal Medicine, S Pietro Fatebenefratelli Hospital, via Cassia 600 Centro ricerche S Pietro AFaR, 00195, Rome, Italy
    Clin Rheumatol 24:285-9. 2005
    ....
  53. ncbi Increased flexion and reduced hospital stay with continuous intraarticular morphine and ropivacaine after primary total knee replacement: open intervention study of efficacy and safety in 154 patients
    Sten Rasmussen
    Department of Orthopedic Surgery, Hamlet Private Hospital, Copenhagen, Denmark
    Acta Orthop Scand 75:606-9. 2004
    ..We have therefore studied the effect of continuous injection of morphine and ropivacaine after TKR on range of movement and length of hospital stay...
  54. ncbi The symptomatic effects of intra-articular administration of hylan G-F 20 on osteoarthritis of the hip: clinical data of 6 months follow-up
    Alberto Migliore
    Research Center S Pietro Hospital, Fatebenefratelli AFaR, Via Cassia 600, 00189 Rome, Italy
    Clin Rheumatol 25:389-93. 2006
    ..The present observation suggests the potentiality for the safety and efficacy of hylan G-F 20 injected under US guidance in patients with symptomatic hip OA. Further controlled studies are needed...
  55. ncbi Viscosupplementation for knee osteoarthritis: a systematic review
    Jon G Divine
    Cincinnati Children s Hospital Research Foundation, Sports Medicine Biodynamics Center and Human Performance Laboratory, Cincinnati, OH 45229, USA
    Clin Orthop Relat Res 455:113-22. 2007
    ....
  56. ncbi Role of hylan G-F 20 in treatment of osteoarthritis of the hip joint
    Vijay B Vad
    Department of Rehabilitation Medicine, Cornell University Medical Center, New York, NY, USA
    Arch Phys Med Rehabil 84:1224-6. 2003
    ..To study the efficacy of hylan G-F 20 in the treatment of osteoarthritis (OA) of the hip joint...
  57. ncbi Clinical features of patients with pain stemming from the lumbar zygapophysial joints. Is the lumbar facet syndrome a clinical entity?
    A C Schwarzer
    Faculty of Medicine, University of Newcastle, Australia
    Spine (Phila Pa 1976) 19:1132-7. 1994
    ..This study is a prospective cross-sectional analytic study...
  58. ncbi Patient's assessment of discomfort during MR arthrography of the shoulder
    C A Binkert
    Department of Radiology, University Hospital Balgrist, Zurich, Switzerland
    Radiology 221:775-8. 2001
    ....
  59. pmc Joint and soft tissue injections in the community: questionnaire survey of general practitioners' experiences and attitudes
    G J Gormley
    Department of General Practice, Queens University Belfast, Dunluce Health Centre, 1 Dunluce Avenue, Belfast, Northern Ireland BT9 7HR
    Ann Rheum Dis 62:61-4. 2003
    ..To investigate the numbers and types of joint and soft tissue injections performed by general practitioners (GPs) and to explore attitudes to training in joint and soft tissue injection and perceived barriers to performing injections...
  60. ncbi Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?
    Peter Ghosh
    Institute of Bone and Joint Research, Department of Surgery, University of Sydney, Royal North Shore Hospital, New South Wales, Australia
    Semin Arthritis Rheum 32:10-37. 2002
    ..All these physicochemical and biologic properties of HA have been shown to be molecular weight (MW) dependent...
  61. ncbi Accuracy of needle placement into the intra-articular space of the knee
    Douglas W Jackson
    Southern California Center for Sports Medicine, Long Beach 90806, USA
    J Bone Joint Surg Am 84:1522-7. 2002
    ..In the absence of a knee effusion, reproducible needle placement into the intra-articular space presents a challenge to the clinician...
  62. ncbi Hip osteoarthritis: short-term efficacy and safety of viscosupplementation by hylan G-F 20. An open-label study in 22 patients
    Olivier Brocq
    Rheumatology Department, CHU l Archet 1, Nice, France
    Joint Bone Spine 69:388-91. 2002
    ..We studied the short-term safety and efficacy of intraarticular hylan G-F 20 (Synvisc) in patients with symptomatic hip osteoarthritis...
  63. ncbi Temporal variations in a modified Neer impingement test can confound clinical interpretation
    John G Skedros
    University of Utah Department of Orthopaedics, Utah Bone and Joint Center, Salt Lake City, UT 84107, USA
    Clin Orthop Relat Res 460:130-6. 2007
    ..Assessing pain at 10 minutes for a Neer-type impingement test can fail to accurately determine a positive test in a substantial percentage of patients...
  64. ncbi A safe, reliable method of carpal tunnel injection
    N R Kay
    Department of Orthopaedic Surgery, Royal Hallamshire Hospital, Sheffield, England
    J Hand Surg Am 17:1160-1. 1992
    ..We present a new method of carpal tunnel injection based on anatomic dissections. We have used this technique successfully for more than 10 years, and there have been no cases of median nerve injury...
  65. ncbi The analgesic efficacy and safety of intra-articular morphine and mepivicaine following temporomandibular joint arthroplasty
    John R Zuniga
    Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Oral Maxillofac Surg 65:1477-85. 2007
    ..This study was designed to evaluate the efficacy and safety of intra-articular morphine, mepivacaine, or a combination of both in the management of temporomandibular joint (TMJ) pain in a 24-hour period after arthroplasty...
  66. ncbi Is there a place for intra-articular hyaluronate in osteoarthritis of the knee?
    J Kirwan
    University Division of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Knee 8:93-101. 2001
    ..Current evidence suggests that viscosupplements probably provide a similar level of pain relief to glucocorticoids and do so for several months, but the onset is slower, and there is the potential for local adverse reactions...
  67. doi Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study
    T Conrozier
    Department of Rheumatology, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Arch Orthop Trauma Surg 129:417-23. 2009
    ..The aim of this study was to assess different dosing regimens of hylan G-F 20, a high molecular-weight cross-linked derivative of HA, in the treatment of pain due to knee OA...
  68. ncbi Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit
    D Uebelhart
    Department of Clinical Neurosciences and Dermatology, University Hospital of Geneva, Switzerland
    Osteoarthritis Cartilage 6:6-13. 1998
    ....
  69. ncbi Thoracic zygapophyseal joint pain patterns. A study in normal volunteers
    P Dreyfuss
    Neuro Skeletal Center, Tyler, Texas
    Spine (Phila Pa 1976) 19:807-11. 1994
    ..Nine asymptomatic volunteers underwent 40 provocative intra-articular injections of the thoracic zygapophyseal joints...
  70. doi Shoulder acute pain in primary healthcare: is retraining effective for GP principals? SAPPHIRE--a randomized controlled trial
    J Watson
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Rheumatology (Oxford) 47:1795-802. 2008
    ..To address the question whether general practitioners (GPs) should receive practical training in shoulder problems and to test whether cortisone injections are better than anaesthetic injections for rotator cuff problems...
  71. ncbi Intraarticular corticosteroids, supervised physiotherapy, or a combination of the two in the treatment of adhesive capsulitis of the shoulder: a placebo-controlled trial
    Simon Carette
    Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Arthritis Rheum 48:829-38. 2003
    ..To compare the efficacy of a single intraarticular corticosteroid injection, a supervised physiotherapy program, a combination of the two, and placebo in the treatment of adhesive capsulitis of the shoulder...
  72. ncbi Aspiration and injection therapies for joints
    H Ralph Schumacher
    University of Pennsylvania and VA Medical Center, Philadelphia, USA
    Arthritis Rheum 49:413-20. 2003
  73. ncbi Diagnostic and therapeutic injection of the shoulder region
    Alfred F Tallia
    Department of Family Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Am Fam Physician 67:1271-8. 2003
    ..The proper technique, choice and quantity of pharmaceuticals, and appropriate follow-up are essential for effective outcomes...
  74. ncbi Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model
    M Mihara
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
    Osteoarthritis Cartilage 15:543-9. 2007
    ..We examined the effects of nonsteroidal anti-inflammatory drug (NSAID) and intra-articular injections of sodium hyaluronate (HA) on cartilage degeneration in rabbit knee osteoarthritis (OA) model induced by partial meniscectomy...
  75. ncbi Efficacy and safety of viscosupplementation by ultrasound-guided intra-articular injection in osteoarthritis of the hip
    A Migliore
    Department of Internal Medicine, S Pietro Fatebenefratelli Hospital, Rome, Italy
    Osteoarthritis Cartilage 11:305-6. 2003
  76. ncbi Viscosupplementation therapy for osteoarthritis
    Stephen F Brockmeier
    Department of Orthopaedic Surgery, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Sports Med Arthrosc 14:155-62. 2006
    ..This paper will review the development, experience, indications, and clinical outcomes of viscosupplementation therapy in patients with osteoarthritis...
  77. pmc A pragmatic randomised controlled trial of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care
    E M Hay
    Staffordshire Rheumatology Centre, The Haywood, Burslem, Stoke on Trent, North Staffordshire ST6 7AG, UK
    Ann Rheum Dis 62:394-9. 2003
    ..To compare the long term effectiveness of local steroid injections administered by general practitioners with practice based physiotherapy for treating patients presenting in primary care with new episodes of unilateral shoulder pain...
  78. ncbi MR arthrography of the glenohumeral joint: modified posterior approach without imaging guidance
    Onofrio A Catalano
    Department of Radiology, AO G Rummo, Via Provinciale 93, Beltiglio, BN, 82010, Italy
    Radiology 242:550-4. 2007
    ..The mean extension of extravasation was 15 mm. Image quality was not compromised, and no gas bubbles were detected. The procedure was successful in all patients, with no complications...
  79. ncbi The efficacy of subacromial corticosteroid injection in the treatment of rotator cuff disease: A systematic review
    Michael C Koester
    Orthopaedic Healthcare Northwest, Eugene, OR, USA
    J Am Acad Orthop Surg 15:3-11. 2007
    ..This systematic review of the available literature indicates that there is little reproducible evidence to support the efficacy of subacromial corticosteroid injection in managing rotator cuff disease...
  80. pmc Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action
    Larry W Moreland
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Res Ther 5:54-67. 2003
    ..Many of the physiological effects of exogenous HA may be a function of its molecular weight. Several physiological effects probably contribute to the mechanisms by which HA and hylans exert their clinical effects in knee OA...
  81. ncbi Predictors of clinical response to intraarticular Hylan injections -- a prospective study using synovial fluid measures, clinical outcomes, and magnetic resonance imaging
    Ananthila Anandacoomarasamy
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    J Rheumatol 35:685-90. 2008
    ..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections...
  82. ncbi Reduced pain of intraarticular hyaluronate injection with the reciprocating procedure device
    Sharon E Nunez
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Clin Rheumatol 13:16-9. 2007
    ..The RPD increases physician control of the needle and is proposed to reduce patient pain during syringe procedures...
  83. ncbi Preliminary results of integrated therapy for patients with knee osteoarthritis
    Mao Hsiung Huang
    Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Arthritis Rheum 53:812-20. 2005
    ..To investigate the effects of integrated therapy on the functional status of patients with knee osteoarthritis (OA)...
  84. doi Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial
    C Lundsgaard
    Department of Geriatrics and Rheumatology, Glostrup Hospital the county of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Rheumatol 37:142-50. 2008
    ..We conducted a randomized, patient- and observer-blind trial to evaluate these interventions in patients with painful knee osteoarthritis...
  85. ncbi The clinical effectiveness of hyaluronan products
    Jeffrey L Kraines
    Am J Orthop (Belle Mead NJ) 37:128; author reply 128, 152. 2008
  86. pmc Multicentre, prospective, open study to evaluate the safety and efficacy of hylan G-F 20 in knee osteoarthritis subjects presenting with pain following arthroscopic meniscectomy
    J P Huskin
    CHU Liège Sart Tilman, Sce Orthopédie, B 35, 4000, Liege 1, Belgium
    Knee Surg Sports Traumatol Arthrosc 16:747-52. 2008
    ..The risk/benefit of hylan G-F 20 in this particular population of patients is favourable...
  87. ncbi BLISS index for analyzing knee osteoarthritis trials data
    Nicholas Bellamy
    Centre of National Research on Disability and Rehabilitation Medicine CONROD, The University of Queensland, Queensland, Australia, 4006
    J Clin Epidemiol 60:124-32. 2007
    ..A method, termed the BLISS (Bellamy et al. Low Intensity Symptom State-attainment) Index, for analyzing OA knee clinical trials data, was proposed...
  88. ncbi Overall tolerability and analgesic activity of intra-articular sodium hyaluronate in the treatment of knee osteoarthritis
    R Theiler
    Rheumatology Clinic and Institute for Physical Medicine and Rehabilitation, Tremli City Hospital, Zurich, Switzerland
    Curr Med Res Opin 21:1727-33. 2005
    ..8% solution of highly purified sodium hyaluronate for intra-articular application. The aim of the present study was to investigate the safety and tolerability profile of this preparation in patients with symptomatic knee OA over 24 weeks...
  89. ncbi Nociceptive nerve activity in an experimental model of knee joint osteoarthritis of the guinea pig: effect of intra-articular hyaluronan application
    Ana Gomis
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, 03550 Sant Joan d Alacant, Spain
    Pain 130:126-36. 2007
    ..Intra-articular injection of an elastoviscous hyaluronan solution reduced the augmented nerve activity...
  90. ncbi Comparison of intraarticular injection of depot corticosteroid and hyaluronic acid for treatment of degenerative trapeziometacarpal joints
    Shalom Stahl
    Hand Surgery Unit, Rambam Medical Center and Technion Israel Institute of Technology, Haifa
    J Clin Rheumatol 11:299-302. 2005
    ..Nonoperative treatment at an early stage includes intraarticular steroid injection. Although this treatment may bring about prompt symptomatic relief, its efficacy is unpredictable...
  91. ncbi Post-Hoc analysis of a head-to-head hyaluronic acid comparison in knee osteoarthritis using the 2004 OMERACT-OARSI responder criteria
    Erol Onel
    Ferring Pharmaceuticals Inc, Parsippany, NJ 07054, USA
    Clin Drug Investig 28:37-45. 2008
    ..These criteria focus on change in pain and physical function. The aim of this study was to reanalyse the data from the original comparative study of hylan G-F 20 and Bio-HA in knee OA utilising the new OMERACT-OARSI response criteria...
  92. ncbi Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients: open-label, randomized, multicentre clinical trial
    P B Lee
    Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Int Med Res 34:77-87. 2006
    ..There was no significant difference in side-effects between the groups. In conclusion, the efficacy and safety of high and low molecular weight hyaluronate are similar...
  93. doi The use of hylan G-F 20 after knee arthroscopy in an active patient population with knee osteoarthritis
    Patrick M Zietz
    West Michigan Orthopaedics, Grand Rapids, Michigan, USA
    Arthroscopy 24:416-22. 2008
    ..The purpose of this study was to evaluate the efficacy of hylan G-F 20 when used to treat an active and athletic patient population with knee osteoarthritis who had undergone knee arthroscopy for mechanical symptoms...
  94. ncbi [Correlation between radiologic and ultrasonographic patterns and clinical manifestations in symptomatic hip osteoarthritis]
    A Migliore
    U O S di Reumatologia, Ospedale S Pietro Fatebenefratelli, Roma, Italia
    Reumatismo 59:57-65. 2007
    ..Further studies are needed to evaluate their prevalence in hip OA symptomatic and not-symptomatic patients and their correlation to treatment outcome...
  95. ncbi Hyaluronate improves pain, physical function and balance in the geriatric osteoarthritic knee: a 6-month follow-up study using clinical tests
    Shu Fen Sun
    Department of Physical Medicine and Rehabilitation, Veterans General Hospital, Kaohsiung, Taiwan
    Osteoarthritis Cartilage 14:696-701. 2006
    ..To investigate the effects of intraarticular hyaluronic acid (HA) (Artzal, Seikagaku Corp., Japan) in geriatric participants with unilateral knee osteoarthritis (OA)...
  96. ncbi Knee osteoarthritis: should your patient opt for hyaluronic acid injection?
    Jennifer M Medina
    The Pennsylvania State University, 46 Recreation Building, University Park, PA 16802, USA
    J Fam Pract 55:669-75. 2006
  97. ncbi Efficacy and safety of hyaluronan treatment in combination therapy with home exercise for knee osteoarthritis pain
    Todd P Stitik
    Department of Physical Medicine and Rehabilitation, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Arch Phys Med Rehabil 88:135-41. 2007
    ..To assess the efficacy and safety of intra-articular injections of sodium hyaluronate combined with a home exercise program (HEP) in the management of pain associated with osteoarthritis (OA) of the knee...
  98. ncbi Intraarticular injection of high molecular weight hyaluronan for osteoarthritis of the knee - prediction of effectiveness with biological markers
    Haruo Sugimoto
    Department of Orthopaedic Surgery, Fujita Health University, Second Hospital, Tokyo, Japan
    J Rheumatol 33:2527. 2006
    ..The possibility of predicting the effectiveness of intraarticular injection of high molecular weight hyaluronan (HA) was investigated using biological markers...
  99. ncbi Clinical experience with the effectiveness and tolerability of hylan G-F 20 in 1047 patients with osteoarthritis of the knee
    David D Waddell
    Orthopedic Specialists of Louisiana, Shreveport 71103, USA
    J Knee Surg 19:19-27. 2006
    ..3% of injections. Our clinical experience shows that hylan G-F 20 effectively relieves osteoarthritis knee pain (as indicated) and reduces pain medication needed for up to 6 months with a low incidence of local adverse events...
  100. ncbi Hyaluronate effects on synovium and synovial fluid. A prospective blinded study in patients with osteoarthritis of the knee
    H R Schumacher
    VA Medical Center 151K, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Osteoarthritis Cartilage 14:501-3. 2006
  101. ncbi Efficacy and safety of intraarticular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial
    Peter Juni
    University of Berne, Berne, Switzerland
    Arthritis Rheum 56:3610-9. 2007
    ..To compare the efficacy and safety of intraarticular hylan and 2 hyaluronic acids (HAs) in osteoarthritis (OA) of the knee...

Research Grants96

  1. TARGETED NANOTHERAPY IN THE TREATMENT OF INFLAMMATORY ARTHRITIS
    Christine Pham; Fiscal Year: 2009
    ..In conjunction, we will develop MR molecular imaging technologies based on targeted nanoparticles to track early therapeutic responses in a rabbit model of inflammatory arthritis. ..
  2. N-Acetylglucosamine Treatment of Osteoarthritis
    Yoshitaka Ichikawa; Fiscal Year: 2003
    ..2. Assess therapeutic efficacy of GIcNAc formulations in rabbits with experimentally induced OA. These studies have the potential to provide the basis for a safe and effective chondroprotective therapy for OA. ..
  3. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..The results will establish the capacity of HA/TGF-B to sustain proteoglycan syntheses to facilitate repair of osteoarthritic articular cartilage...
  4. STUDY OF SAFETY & EFFECTIVENESS OF INTRAARTICULAR ORTHOVISC INJECTION
    Stephen Myers; Fiscal Year: 1999
    ..double blind controled trial to assess the safety and effectiveness of a series of three weekly intra articular injections of Orthovisc in providing pain relief for osteoarthritis of the knee...
  5. STUDY OF SAFETY & EFFECTIVENESS OF INTRAARTICULAR ORTHOVISC INJECTION
    Stephen Myers; Fiscal Year: 1999
    ..double blind controlled trial to assess the safety and effectiveness of a series of three weekly intra articular injections of Orthovisc in providing pain relief for osteoarthritis of the knee...
  6. STUDY OF SAFETY & EFFECTIVENESS OF INTRAARTICULAR ORTHOVISC INJECTION
    Stephen Myers; Fiscal Year: 1999
    ..double blind controled trial to assess the safety and effectiveness of a series of three weekly intra articular injections of Orthovisc in providing pain relief for osteoarthritis of the knee...
  7. INTRA-ARTICULAR IGF-1 IN SEVERE OSTEOARTHRITIS OF KNEE
    Nancy Lane; Fiscal Year: 2000
    ..After the injections end, the patient will have joint replacement. The GCRC will be utilized for the injections by the PI and phlebotomy by the nursing staff. ..
  8. HYALURONIC ACID AND ARTHRITIS
    ENDRE BALAZS; Fiscal Year: 1980
    ....
  9. Safety of intraarticular N-acetylglucosamine
    Martin Lotz; Fiscal Year: 2007
    ..An escalating dosing scheme will be used including 1,10 and 100mM GlcNAc. Patients will be monitored for local and systemic adverse reactions. [unreadable] [unreadable] [unreadable]..
  10. TARGETED NANOTHERAPY IN THE TREATMENT OF INFLAMMATORY ARTHRITIS
    CHRISTINE T PHAM; Fiscal Year: 2010
    ..In conjunction, we will develop MR molecular imaging technologies based on targeted nanoparticles to track early therapeutic responses in a rabbit model of inflammatory arthritis. ..
  11. Safety of intraarticular N-acetylglucosamine
    Martin Lotz; Fiscal Year: 2006
    ..An escalating dosing scheme will be used including 1,10 and 100mM GlcNAc. Patients will be monitored for local and systemic adverse reactions. [unreadable] [unreadable] [unreadable]..
  12. Intraarticular injection of polyglucosamine for knee OA
    MAURIZIO CATTANEO; Fiscal Year: 2002
    ..3) Examine the extent of lesions in a blind fashion using morphological, histological and biochemical evaluations. ..
  13. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
    ..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. [unreadable] [unreadable] [unreadable]..
  14. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  15. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  16. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2006
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. [unreadable] [unreadable] [unreadable]..
  17. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2006
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  18. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2007
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. [unreadable] [unreadable] [unreadable]..
  19. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2008
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  20. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  21. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2005
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  22. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2002
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  23. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2000
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  24. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 1999
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  25. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  26. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2001
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  27. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..Thus, pharmaceutical agents aimed at inhibition of ASICs are promising in that they not only have the potential to reduce the inflammatory process but also have a direct role in inhibiting musculoskeletal pain. ..
  28. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  29. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  30. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  31. NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENT
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..abstract_text> ..
  32. Recombinant FIV vectors for the delivery of siRNA therapy to joints
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Does peripheral localized chronic inflammation predispose to neurodegeneration?
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. Gene therapy for treatment of craniofacial dysplasia
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
  36. 2008 Viral Vectors for Gene Therapy, The Science of Gordon Research Conference
    Paul Robbins; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  37. REGULATION OF TRANSCRIPTION-RETINOBLASTOMA ANTI-ONCOGENE
    Paul Robbins; Fiscal Year: 1993
    ..The successful completion of the project should significantly increase our understanding of the mechanism of action of an anti-oncogene and could potentially lead to a biological treatment for certain cancers...
  38. Inhibition of NF-KB to Facilitate Islet Transplantation
    Paul Robbins; Fiscal Year: 2003
    ..The successful completion of the proposed studies should determine if NF-kB inhibition in islets by peptide and gene mediated transduction is able to improve islet viability prior to and post-transplantation. ..
  39. REGULATION OF TRANSCRIPTION BY THE RB ANTIONCOGENE
    Paul Robbins; Fiscal Year: 2002
    ..The experiments described in the proposal are expected to provide important insights into the mechanism of how RB and cyclin D1 function to regulate transcription directly, cell differentiation, and tumorigenesis. ..
  40. Asymtomatic Cuff Tears: A Model for Pain Development
    KEN contact YAMAGUCHI; Fiscal Year: 2010
    ..This study proposes to follow individuals with rotator cuff tears and no pain over an extended period of time to determine the risk of new pain and deterioration of the cuff. ..
  41. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..
  42. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2008
    ..The long-term goal of this project is the better understanding of higher brain functions involved in the different pain components to improve pain management strategies and decision making. ..
  43. Chondroprotection mediated by GFAT gene transfer
    Jean Noel Gouze; Fiscal Year: 2008
    ..If successfully completed, this study will lead to further insight to the biological effects of glucosamine on arthritis and perhaps the development of a novel chondroprotective strategy for the treatment of OA. ..
  44. Asymptomatic Cuff Tears: A model for Pain Development
    Ken Yamaguchi; Fiscal Year: 2008
    ..Most importantly, the information should be critical in formulating indications and objectives for operative intervention a fundamental issue in caring for patients with rotator cuff tears. ..
  45. An RCT for Treating Carpometacarpal Osteoarthritis
    LISA MANDL; Fiscal Year: 2008
    ..This will fill a gap in the literature, and provide evidence-based data for intra-articular corticosteroids, the present use of which is based only on anecdotal and conventional practices. ..
  46. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2008
    ....
  47. Pain, Nociception, and the Amygdal
    Volker Neugebauer; Fiscal Year: 2009
    ..The long-term goal of this project is the better understanding of higher brain functions involved in the different pain components to improve pain management strategies and decision making. ..
  48. AOSSM Post-Joint Injury Osteoarthritis Conference
    Constance Chu; Fiscal Year: 2008
    ..This symposium will bring doctors and scientists together to develop research plans to find new methods to prevent this from happening. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Restitution of Lubrication in ACL Deficient Joints Preventing Wear
    Gregory Jay; Fiscal Year: 2008
    ..We also hypothesize that blocking the effects of TNF-a through the administration of a TNF-a inhibitor (Enbrel) partially restores the lubricating ability of diarthrodial joints following ACL injury. ..
  50. PAIN, NOCICEPTION AND THE AMYGDALA
    Volker Neugebauer; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Asymptomatic Cuff Tears: A model for Pain Development
    Ken Yamaguchi; Fiscal Year: 2006
    ..Most importantly, the information should be critical in formulating indications and objectives for operative intervention a fundamental issue in caring for patients with rotator cuff tears. ..
  52. Functional Impact of PENS for 65+ Chronic Low Back Pain
    Debra Weiner; Fiscal Year: 2004
    ....
  53. Estrogen and Inflammation in TMD Pain
    DAVID BEREITER; Fiscal Year: 2006
    ..This information may lead to a better understanding of how the brain integrates pain-like signals relevant for TMD in women ..
  54. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2005
    ..Subjects will be treated for 8 weeks and followed for a total of 6 months. Results of this study will direct future investigations with respect to dose effect, mechanism and optimal prescriptive parameters ..
  55. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2001
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..
  56. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2006
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. [unreadable] [unreadable] [unreadable]..
  57. TRIGEMINAL CONTROL OF ADRENAL AUTONOMIC FUNCTION
    DAVID BEREITER; Fiscal Year: 1993
    ....
  58. EVALUATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM
    Richard Coutts; Fiscal Year: 1991
    ....
  59. Chondroprotection mediated by GFAT gene transfer
    Jean Noel Gouze; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2003
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..
  61. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA GILLANI; Fiscal Year: 2008
    ..In addition, this proposal will lead to important information regarding the role of neuronal plasticity in brain repair after stroke. ..
  62. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2009
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
  63. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  64. Chondrogenesis In Situ
    Constance R Chu; Fiscal Year: 2010
    ....
  65. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2009
    ....
  66. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2002
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..
  67. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2009
    ..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..
  68. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance R Chu; Fiscal Year: 2010
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
  69. ELECTROSTIMULATION FOR STROKE REHAB: EFFECTS & MECHANISM
    John Chae; Fiscal Year: 2002
    ..Finally, techniques developed for assessing central motor function may be useful for evaluating other interventions directed at stroke rehabilitation. ..
  70. CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE
    Constance Chu; Fiscal Year: 2002
    ..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..
  71. Chondrogenesis In Situ
    Constance R Chu; Fiscal Year: 2010
    ....
  72. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2009
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  73. An RCT for Treating Carpometacarpal Osteoarthritis
    LISA MANDL; Fiscal Year: 2007
    ..This will fill a gap in the literature, and provide evidence-based data for intra-articular corticosteroids, the present use of which is based only on anecdotal and conventional practices. ..
  74. Oral Opioid Treatment and Psychiatric Comorbidity
    Ajay Wasan; Fiscal Year: 2007
    ..abstract_text> ..
  75. Electrical stimulation for upper limb recovery in stroke
    John Chae; Fiscal Year: 2007
    ..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..
  76. Clinical Trials in Stroke Rehabilitation
    John Chae; Fiscal Year: 2007
    ....
  77. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2007
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  78. Chondrogenesis In Situ
    Constance Chu; Fiscal Year: 2007
    ....
  79. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA GILLANI; Fiscal Year: 2007
    ..In addition, this proposal will lead to important information regarding the role of neuronal plasticity in brain repair after stroke. ..
  80. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2008
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  81. Clinical Trials in Stroke Rehabilitation
    John Chae; Fiscal Year: 2008
    ....
  82. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2008
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
  83. Electrical stimulation for upper limb recovery in stroke
    John Chae; Fiscal Year: 2008
    ..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..
  84. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2006
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  85. Electrical stimulation for upper limb recovery in stroke
    John Chae; Fiscal Year: 2005
    ..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..
  86. Oral Opioid Treatment and Psychiatric Comorbidity
    Ajay Wasan; Fiscal Year: 2008
    ..abstract_text> ..
  87. Electrical stimulation for upper limb recovery in stroke
    John Chae; Fiscal Year: 2006
    ..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..
  88. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2004
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..
  89. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2007
    ..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. [unreadable] [unreadable] [unreadable]..