intra articular injections

Summary

Top Publications

  1. ncbi Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint
    H M van Beuningen
    Department of Rheumatology, University Hospital St Radboud, Nijmegen, The Netherlands
    Lab Invest 71:279-90. 1994
  2. ncbi Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee
    Roy D Altman
    GRECC, Miami VAMC, Miami, FL, USA
    Osteoarthritis Cartilage 12:642-9. 2004
  3. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
  4. pmc Intra-articular therapy in osteoarthritis
    I Uthman
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Postgrad Med J 79:449-53. 2003
  5. ncbi Intraarticular drug delivery in osteoarthritis
    Nicole Gerwin
    Bone and Cartilage Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, WKL 125 13 59, CH 4002 Basel, Switzerland
    Adv Drug Deliv Rev 58:226-42. 2006
  6. ncbi Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial
    Karen Toftdahl
    Department of Anesthesiology, Aarhus University Hospital, Denmark
    Acta Orthop 78:172-9. 2007
  7. ncbi The targeting accuracy of subacromial injection to the shoulder: an arthrographic evaluation
    Kotaro Yamakado
    Department of Orthopaedics, Kahoku Central Hospital, Japan
    Arthroscopy 18:887-91. 2002
  8. ncbi Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study
    Hari K Parvataneni
    Massachusetts General Hospital, Boston, Massachusetts, USA
    J Arthroplasty 22:33-8. 2007
  9. ncbi Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysate
    Yen Hsuan Jean
    Graduate Institute of Medical Science, National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
    J Orthop Res 24:1052-61. 2006
  10. ncbi Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy
    W Wenz
    Orthopaedic University Clinic Heidelberg, Germany
    J Orthop Res 18:604-12. 2000

Research Grants

  1. N-Acetylglucosamine Treatment of Osteoarthritis
    Yoshitaka Ichikawa; Fiscal Year: 2003
  2. Tribosupplementation of Injured Joints
    Gregory D Jay; Fiscal Year: 2013
  3. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
  4. TARGETED NANOTHERAPY IN THE TREATMENT OF INFLAMMATORY ARTHRITIS
    CHRISTINE T PHAM; Fiscal Year: 2012
  5. HYALURONIC ACID AND ARTHRITIS
    ENDRE BALAZS; Fiscal Year: 1980
  6. Intraarticular injection of polyglucosamine for knee OA
    MAURIZIO CATTANEO; Fiscal Year: 2002
  7. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
  8. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
  9. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
  10. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003

Detail Information

Publications216 found, 100 shown here

  1. ncbi Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint
    H M van Beuningen
    Department of Rheumatology, University Hospital St Radboud, Nijmegen, The Netherlands
    Lab Invest 71:279-90. 1994
    ..In an earlier study, we found no effect on cartilage proteoglycan metabolism shortly after a single intra-articular injection of TGF-beta 1. In the present study, we used multiple intra-articular injections and a longer time-scale...
  2. ncbi Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee
    Roy D Altman
    GRECC, Miami VAMC, Miami, FL, USA
    Osteoarthritis Cartilage 12:642-9. 2004
    ..This study compared the efficacy of a single injection of NASHA with placebo in patients with osteoarthritis (OA) of the knee...
  3. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
    ..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...
  4. pmc Intra-articular therapy in osteoarthritis
    I Uthman
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Postgrad Med J 79:449-53. 2003
    ..The virtual absence of serious side effects, coupled with the perceived benefits, make these approaches attractive...
  5. ncbi Intraarticular drug delivery in osteoarthritis
    Nicole Gerwin
    Bone and Cartilage Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, WKL 125 13 59, CH 4002 Basel, Switzerland
    Adv Drug Deliv Rev 58:226-42. 2006
    ..The development of novel drugs in combination with new formulations for IA treatment of OA, represents a promising approach in this challenging area of research...
  6. ncbi Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial
    Karen Toftdahl
    Department of Anesthesiology, Aarhus University Hospital, Denmark
    Acta Orthop 78:172-9. 2007
    ..Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. Recent studies have suggested that periarticular infiltration with local anesthetics may improve outcome...
  7. ncbi The targeting accuracy of subacromial injection to the shoulder: an arthrographic evaluation
    Kotaro Yamakado
    Department of Orthopaedics, Kahoku Central Hospital, Japan
    Arthroscopy 18:887-91. 2002
    ..The study goal was to examine the targeting accuracy of subacromial injection to the shoulder and the influence of the location of the injected structure...
  8. ncbi Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study
    Hari K Parvataneni
    Massachusetts General Hospital, Boston, Massachusetts, USA
    J Arthroplasty 22:33-8. 2007
    ..Periarticular injection with a multimodal protocol was shown to safely provide excellent pain control and functional recovery and can be substituted for conventional pain control modalities...
  9. ncbi Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysate
    Yen Hsuan Jean
    Graduate Institute of Medical Science, National Defense Medical Center, 325, Chenggung Road, Section 2, Neihu 114, Taipei, Taiwan, Republic of China
    J Orthop Res 24:1052-61. 2006
    ..This study suggests that the underlying mechanism of the anti-inflammatory effect of HA is to inhibit glutamate and aspartate release in ACLT knee joints, which attenuates the early development of OA...
  10. ncbi Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy
    W Wenz
    Orthopaedic University Clinic Heidelberg, Germany
    J Orthop Res 18:604-12. 2000
    ..Therefore, we conclude that the use of hyaluronan may be indicated during the early stages of chondromalacia...
  11. ncbi Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors
    M J Janusz
    Procter and Gamble Pharmaceuticals, Inc, 8700 Mason Montgomery Rd, Mason, Ohio 45040 9462, USA
    Osteoarthritis Cartilage 9:751-60. 2001
    ..To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced arthritis in rats...
  12. ncbi Aspiration and injection therapies for joints
    H Ralph Schumacher
    University of Pennsylvania and VA Medical Center, Philadelphia, USA
    Arthritis Rheum 49:413-20. 2003
  13. ncbi A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis
    J Song
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea
    Eur J Nucl Med 28:489-97. 2001
    ....
  14. ncbi Evaluation of therapeutic thoracic medial branch block effectiveness in chronic thoracic pain: a prospective outcome study with minimum 1-year follow up
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Kentucky 42003, USA
    Pain Physician 9:97-105. 2006
    ..These interventions have not been evaluated in managing chronic thoracic pain of facet joint origin...
  15. ncbi The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 67:1716-23. 2008
    ....
  16. ncbi Increases in lumbosacral injections in the Medicare population: 1994 to 2001
    Janna Friedly
    Department of Rehabilitation Medicine, University of Washington, Harborview Medical Center, Seattle, WA 98127, USA
    Spine (Phila Pa 1976) 32:1754-60. 2007
    ..Anecdotal reports and limited data suggest that the use of spinal injections is increasing, despite equivocal evidence about efficacy...
  17. ncbi Evaluation of the pituitary-adrenal axis function following single intraarticular injection of methylprednisolone
    Reuven Mader
    Ha Emek Medical Center, Afula, Israel
    Arthritis Rheum 52:924-8. 2005
    ..To determine the effects of a single session of intraarticular methylprednisolone (IA-MP) injections on the function of the pituitary-adrenal axis...
  18. ncbi Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
    Karen V Andersen
    Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 78:180-6. 2007
    ..We compared wound infiltration combined with intraarticular injection of local anesthetics for pain relief after total hip arthroplasty (THA) with the well-established practice of epidural infusion...
  19. pmc Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis
    A R Shikhman
    Division of Arthritis Research, The Scripps Research Institute, La Jolla, CA, USA
    Ann Rheum Dis 64:89-94. 2005
    ..To examine the therapeutic efficacy of N-acetylglucosamine (GlcNAc) in rabbits with experimental osteoarthritis (OA)...
  20. ncbi A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee
    Robert J Petrella
    Department of Family Medicin, Schulich School of Medicine and School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada
    J Rheumatol 33:951-6. 2006
    ....
  21. ncbi [Safety profile of 185 ultrasound-guided intra-articular injections for treatment of rheumatic diseases of the hip]
    A Migliore
    Dipartimento Medicina Interna, Ospedale S Pietro Fatebenefratelli, Rome, Italy
    Reumatismo 56:104-9. 2004
    ..The purpose of this study was to examine the safety of this technique in an extended series of patients...
  22. ncbi Changes in sagittal ground reaction forces after intra-articular hyaluronate injections for knee osteoarthritis
    Simon F Tang
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, 5 Fu Hsin Street, Kwei Shan, Tao Yuan 333, Taiwan
    Arch Phys Med Rehabil 85:951-5. 2004
    ..To examine the gait patterns and the sagittal ground reaction forces (GRFs) in persons with knee osteoarthritis (OA) after intra-articular injection of hyaluronate and to investigate the duration of its treatment effectiveness...
  23. ncbi Safety and efficacy of ultrasound-guided intra-articular hylan G-F 20 injection in osteoarthritis of the hip: a pilot study
    Hanife Caglar-Yagci
    Physical Medicine and Rehabilitation Department, Ankara Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey
    Rheumatol Int 25:341-4. 2005
    ....
  24. ncbi Injectable corticosteroids in modern practice
    Brian J Cole
    Rush Cartilage Restoration Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Am Acad Orthop Surg 13:37-46. 2005
    ..The accuracy of injections affects outcomes. Postinjection flare, facial flushing, and skin and fat atrophy are the most common side effects. Systemic complications of injectable corticosteroids are rare...
  25. ncbi Clinical experience with the effectiveness and tolerability of hylan G-F 20 in 1047 patients with osteoarthritis of the knee
    David D Waddell
    Orthopedic Specialists of Louisiana, Shreveport 71103, USA
    J Knee Surg 19:19-27. 2006
    ..3% of injections. Our clinical experience shows that hylan G-F 20 effectively relieves osteoarthritis knee pain (as indicated) and reduces pain medication needed for up to 6 months with a low incidence of local adverse events...
  26. ncbi Aids to successful shoulder arthrography performed with a fluoroscopically guided anterior approach
    Jon A Jacobson
    Department of Radiology, University of Michigan Medical Center, 1500 E Medical Center Dr, TC 2910G, Ann Arbor, MI 48109 0326, USA
    Radiographics 23:373-8; discussion 379. 2003
    ..Proper patient and needle positioning as well as accurate confirmation of intraarticular needle placement are critical to a successful and atraumatic shoulder arthrographic examination...
  27. ncbi Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline
    E Qvistgaard
    The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, DK 2000 Copenhagen F, 2000 Frederiksberg, Denmark
    Osteoarthritis Cartilage 14:163-70. 2006
    ..Hyaluronic acid (HA) and corticosteroids are both widely used for intra-articular treatment of knee osteoarthritis (OA). We examined the effect of both drugs in intra-articular treatment for hip OA...
  28. ncbi Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: an open-label, multicentre, pilot study
    T Conrozier
    Department of Rheumatology, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Clin Exp Rheumatol 21:605-10. 2003
    ..To obtain prospective data on feasibility and safety of intra-articular injections of hylan G-F20 in patients with symptomatic hip osteoarthritis (OA)...
  29. pmc Corticosteroid injections for painful shoulder: a meta-analysis
    Bruce Arroll
    Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, PB 92019, Auckland, New Zealand
    Br J Gen Pract 55:224-8. 2005
    ..There are no systematic reviews of corticosteroids for shoulder pain that calculate the numbers needed to treat...
  30. ncbi Improvement of muscle strength in osteoarthritic knee patients after intraarticular knee injection of hyaluronan
    Simon F T Tang
    Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taiwan
    Am J Phys Med Rehabil 84:274-7. 2005
    ..The objective of this study was to investigate whether the knee concentric and eccentric muscle strengths can be improved in patients with bilateral knee osteoarthritis after intraarticular hyaluronan injections...
  31. ncbi Arthrography of the shoulder: a simple fluoroscopically guided approach for targeting the rotator cuff interval
    Hélène Dépelteau
    Radiology Department, Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, 1058 Saint Denis St, Montreal, QC H2X 3J4, Canada
    AJR Am J Roentgenol 182:329-32. 2004
    ..The objective of this article is to describe a simplified fluoroscopically guided technique of shoulder joint injection that uses the rotator cuff interval...
  32. ncbi Comparison of the efficacy of lower and higher molecular weight viscosupplementation in the treatment of hip osteoarthritis
    Canan Tikiz
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Celal Bayar, Manisa, Turkey
    Clin Rheumatol 24:244-50. 2005
    ..However, no significant difference was found in outcomes between higher and lower molecular weight hyaluronan...
  33. ncbi Cushing's syndrome after intra-articular and intradermal administration of triamcinolone acetonide in three pediatric patients
    Seema Kumar
    Division of Pediatric Endocrinology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pediatrics 113:1820-4. 2004
    ..Intra-articular and intradermal steroids are often used for their antiinflammatory effect. There is limited experience with intra-articular and intralesional administration of corticosteroids in the pediatric age group...
  34. pmc Randomised controlled trial of single, subacromial injection of methylprednisolone in patients with persistent, post-traumatic impingment of the shoulder
    J J McInerney
    Emergency Department, Mater Misericordiae Hospital, Dublin, Republic of Ireland Leicester Royal Infirmary, Leicester, UK
    Emerg Med J 20:218-21. 2003
    ..To evaluate the impact on recovery, of single subacromial injection of methylprednisolone in patients with persistent, post-traumatic impingement of the shoulder...
  35. ncbi Accuracy and dispersal of subacromial and glenohumeral injections in cadavers
    Nigel Hanchard
    Teesside Centre for Rehabilitation Sciences, The James Cook University Hospital, University of Teesside, Middlesbrough, TS4 3BW, UK
    J Rheumatol 33:1143-6. 2006
    ..Blind" shoulder injections are often inaccurate and infiltrate untargeted structures. We tested a hypothesis that optimizing certain anatomical and positional factors would improve accuracy and reduce dispersal...
  36. ncbi Lumbar zygapophysial (facet) joint injections
    P H Dreyfuss
    Neuro Skeletal Center, Tyler, Texas USA
    Spine (Phila Pa 1976) 20:2040-7. 1995
    ..The need for future studies is addressed, and current recommendations for the role of zygapophysial joint injection procedures based on this critical scientific review are provided...
  37. ncbi Systematic review of diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: an update
    Nalini Sehgal
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53595, USA
    Pain Physician 10:213-28. 2007
    ..There is, however, no available gold standard to measure presence or absence of pain. Hence, there is a degree of uncertainty concerning the accuracy of diagnostic facet joint injections...
  38. ncbi The ability of computed tomography to identify a painful zygapophysial joint in patients with chronic low back pain
    A C Schwarzer
    Faculty of Medicine, University of Newcastle, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Spine (Phila Pa 1976) 20:907-12. 1995
    ..CONCLUSIONS. Computed tomography has no place in the diagnosis of lumbar zygapophysial joint pain...
  39. ncbi Guidance by ultrasound of intra-articular injections in the knee and hip joints
    E Qvistgaard
    The Parker Institute, Department of Rheumatology, H:S Frederiksberg Hospital, Copenhagen, Denmark
    Osteoarthritis Cartilage 9:512-7. 2001
    ..The method is proposed as a tool for both learning purposes and quality assurance in daily therapy...
  40. ncbi Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model
    K Takahashi
    Department of Orthopedics, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0630, USA
    J Orthop Res 19:500-3. 2001
    ..The results suggest that the inhibition of NO production in meniscus and synovium might be a part of the mechanism of the therapeutic effect of HA on OA...
  41. ncbi Intra-articular sodium hyaluronate in osteoarthritis of the knee
    R D Altman
    Department of Rheumatology and Immunology, University of Miami School of Medicine, and the Geriatric Research, Education, and Clinical Center, VA Hospital, FL, USA
    Semin Arthritis Rheum 30:11-8. 2000
    ..To better understand the therapeutic role of HA, this review focuses on comparative clinical trial data...
  42. ncbi Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits
    T Kikuchi
    Shiseido Pharmaceutical Research Laboratories, Kanagawa, Japan
    Osteoarthritis Cartilage 6:177-86. 1998
    ..The induction of osteoarthritis-like changes by intra-articular injections of collagenase in the knee joint of mature rabbits was examined...
  43. ncbi Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial
    Jean Pierre Raynauld
    Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Arthritis Rheum 48:370-7. 2003
    ..To evaluate the safety and efficacy of long-term intraarticular (IA) steroid injections for knee pain related to osteoarthritis (OA)...
  44. ncbi Intra-articular injection of high molecular weight hyaluronan after arthrocentesis as treatment for rheumatoid knees with joint effusion
    Nobuyuki Tanaka
    Rheumatology Unit, Sapporo Gorinbashi Orthopedic Hospital in Gorinbashi Hospitals, 2 1, Kawazoe, Minami Ku, Sapporo, Hokkaido, 005 0802, Japan
    Rheumatol Int 22:151-4. 2002
    ....
  45. ncbi Effects of intra-articular hylan G-F 20 injections on clinical and biomechanical characteristics of the knee in osteoarthritis
    Gunes Yavuzer
    Ankara University Medical School, Department of Physical Medicine and Rehabilitation, Ankara, Turkey
    Int J Rehabil Res 28:371-4. 2005
    ..In conclusion, intra-articular Hylan G-F 20 injections not only decrease pain in patients with knee osteoarthritis, but can alter the natural history of the disease by decreasing excessive loads in the knees...
  46. ncbi Viscosupplementation in symptomatic severe hip osteoarthritis: a review of the literature and report on 60 patients
    Michel P J van den Bekerom
    University Hospital Pellenberg, Leuven, Belgium
    Acta Orthop Belg 72:560-8. 2006
    ..In this article we present a literature review on the subject and report the results in 60 patients who received intraarticular viscosupplementation of the hip with the objective to delay total hip replacement surgery...
  47. ncbi Is local subacromial corticosteroid injection beneficial in subacromial impingement syndrome?
    Kenan Akgun
    Physical Medicine and Rehabilitation Department, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Clin Rheumatol 23:496-500. 2004
    ..We found that subacromial corticosteroid injections in the acute or subacute phase of SIS provided additional short-term benefit without any complication when used together with nonsteroidal anti-inflammatory drugs (NSAIDs) and exercise...
  48. ncbi Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group
    R D Altman
    Department of Rheumatology and Immunology, University of Miami, Florida, USA
    J Rheumatol 25:2203-12. 1998
    ..To determine efficacy and safety of intraarticular (IA) hyaluronic acid (HA; Hyalgan) versus placebo and a nonsteroidal antiinflammatory drug for osteoarthritis (OA) of the knee...
  49. ncbi Long-term effect of sodium hyaluronate (Hyalgan) on osteoarthritis progression in a rabbit model
    D Amiel
    Department of Orthopaedics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0630, USA
    Osteoarthritis Cartilage 11:636-43. 2003
    ..One of the currently available products is approved for repeat treatment courses. While HA is classed as a symptom-modifying agent, there is substantial evidence that this therapeutic modality also possesses disease-modifying activity...
  50. ncbi Intra-articular hyaluronan injections for the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled study
    E Tamir
    Department of Orthopedics, Assaf Harofe Hospital, Zerifin, Israel
    Clin Exp Rheumatol 19:265-70. 2001
    ..It appears that HA with high molecular weights (HMW) are more effective than low molecular weight HA polymers...
  51. pmc Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty
    Per Essving
    Department of Orthopedic Surgery, University of Linkoping, Sweden
    Acta Orthop 80:213-9. 2009
    ..The degree of postoperative pain is usually moderate to severe following knee arthroplasty. We investigated the efficacy of local administration of analgesics into the operating area, both intraoperatively and postoperatively...
  52. ncbi Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience
    Robert J Petrella
    Department of Family Medicine, University of Western Ontario, Ontario, Canada
    Am J Phys Med Rehabil 84:278-83; quiz 284, 293. 2005
    ..Intraarticular hyaluronic acid is indicated for patients with osteoarthritis of the knee. However, clinical experience, especially efficacy and adverse events, with repeated injection series in the long term are limited...
  53. ncbi Low back pain: prediction of short-term outcome of facet joint injection with bone scintigraphy
    Spiros G Pneumaticos
    Institute of Spinal Disorders, Departments of Orthopaedic Surgery and Radiology, Baylor College of Medicine 6550 Fannin, Suite 2525, Houston, TX 77030, USA
    Radiology 238:693-8. 2006
    ..To prospectively evaluate use of bone scintigraphy with single photon emission computed tomography (SPECT) for identification of patients with low back pain who would benefit from facet joint injections...
  54. ncbi Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial
    Constant A Busch
    Division of Orthopaedic Surgery, London Health Sciences Centre, London, Ontario, Canada
    J Bone Joint Surg Am 88:959-63. 2006
    ..Good perioperative analgesia facilitates rehabilitation, improves patient satisfaction, and may reduce the hospital stay. We investigated the analgesic effect of locally injected drugs around a total knee prosthesis...
  55. ncbi A randomized comparative study of short term response to blind injection versus sonographic-guided injection of local corticosteroids in patients with painful shoulder
    Esperanza Naredo
    Department of Rheumatology, The Research Unit, and The Epidemiology Unit, Severo Ochoa Hospital, Madrid, Spain
    J Rheumatol 31:308-14. 2004
    ..We prospectively compared the short term response to randomized blind injection versus sonographic-guided injection of local corticosteroid in patients with painful shoulder...
  56. ncbi Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial
    Domingo Ly-Pen
    Primary Care Unit Gandhi, Madrid, Spain
    Arthritis Rheum 52:612-9. 2005
    ..Optimal treatment of carpal tunnel syndrome (CTS) has not been established. This study compared the effects of local steroid injection versus surgical decompression in new-onset CTS of at least 3 months' duration...
  57. ncbi Accuracy of anterior intra-articular injection of the glenohumeral joint
    Paul M Sethi
    Orthopedic and Neurosurgical Specialists, Greenwich, Connecticut 06830, USA
    Arthroscopy 21:77-80. 2005
    ..This study assessed the accuracy of an anterior intra-articular injection in awake subjects without radiologic assistance...
  58. ncbi Ultrasound-guided facet joint injections in the middle to lower cervical spine: a CT-controlled sonoanatomic study
    Klaus Galiano
    Clinic of Neurosurgery, Innsbruck Medical University, 6020 Innsbruck, Austria
    Clin J Pain 22:538-43. 2006
    ..The aim of this study was to investigate the efficacy of ultrasound as a guiding tool for simulated cervical facet joint injections in cadavers...
  59. ncbi Use of injections for osteoarthritis in joints and sports activity
    Jason C Snibbe
    Kerlan Jobe Orthopaedic Clinic, 6801 Park Terrace, Los Angeles, CA 90045, USA
    Clin Sports Med 24:83-91. 2005
    ..Viscosupplementation has gained popularity in the treatment of osteoarthritis of the knee. Intraarticular injections of hyaluronic acid have shown to decrease pain and improve functional outcomes...
  60. ncbi Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study
    T Conrozier
    Department of Rheumatology, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Arch Orthop Trauma Surg 129:417-23. 2009
    ..The aim of this study was to assess different dosing regimens of hylan G-F 20, a high molecular-weight cross-linked derivative of HA, in the treatment of pain due to knee OA...
  61. ncbi Open pilot study of ultrasound-guided intra-articular injection of hylan G-F 20 (Synvisc) in the treatment of symptomatic hip osteoarthritis
    Alberto Migliore
    Department of Internal Medicine, S Pietro Fatebenefratelli Hospital, via Cassia 600 Centro ricerche S Pietro AFaR, 00195, Rome, Italy
    Clin Rheumatol 24:285-9. 2005
    ....
  62. ncbi Increased flexion and reduced hospital stay with continuous intraarticular morphine and ropivacaine after primary total knee replacement: open intervention study of efficacy and safety in 154 patients
    Sten Rasmussen
    Department of Orthopedic Surgery, Hamlet Private Hospital, Copenhagen, Denmark
    Acta Orthop Scand 75:606-9. 2004
    ..We have therefore studied the effect of continuous injection of morphine and ropivacaine after TKR on range of movement and length of hospital stay...
  63. ncbi Shoulder acute pain in primary healthcare: is retraining effective for GP principals? SAPPHIRE--a randomized controlled trial
    J Watson
    Rheumatology and Rehabilitation Research Unit, University of Leeds, 36 Clarendon Road, Leeds LS2 9NZ, UK
    Rheumatology (Oxford) 47:1795-802. 2008
    ..To address the question whether general practitioners (GPs) should receive practical training in shoulder problems and to test whether cortisone injections are better than anaesthetic injections for rotator cuff problems...
  64. ncbi Intra-articular hylan G-F 20 (Synvisc) in the management of patellofemoral osteoarthritis of the knee (POAK)
    Shane Clarke
    Rheumatology Unit, University Department of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Knee 12:57-62. 2005
    ..5) with 95% confidence and 90% power. This would require a RCT of 104 patients to detect a 15-mm change in VAS (effect size 0.5) with 95% confidence and 90% power...
  65. ncbi The analgesic efficacy and safety of intra-articular morphine and mepivicaine following temporomandibular joint arthroplasty
    John R Zuniga
    Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Oral Maxillofac Surg 65:1477-85. 2007
    ..This study was designed to evaluate the efficacy and safety of intra-articular morphine, mepivacaine, or a combination of both in the management of temporomandibular joint (TMJ) pain in a 24-hour period after arthroplasty...
  66. ncbi Temporal variations in a modified Neer impingement test can confound clinical interpretation
    John G Skedros
    University of Utah Department of Orthopaedics, Utah Bone and Joint Center, Salt Lake City, UT 84107, USA
    Clin Orthop Relat Res 460:130-6. 2007
    ..Assessing pain at 10 minutes for a Neer-type impingement test can fail to accurately determine a positive test in a substantial percentage of patients...
  67. ncbi Viscosupplementation therapy for osteoarthritis
    Stephen F Brockmeier
    Department of Orthopaedic Surgery, Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20007, USA
    Sports Med Arthrosc 14:155-62. 2006
    ..This paper will review the development, experience, indications, and clinical outcomes of viscosupplementation therapy in patients with osteoarthritis...
  68. ncbi Viscosupplementation for knee osteoarthritis: a systematic review
    Jon G Divine
    Cincinnati Children s Hospital Research Foundation, Sports Medicine Biodynamics Center and Human Performance Laboratory, Cincinnati, OH 45229, USA
    Clin Orthop Relat Res 455:113-22. 2007
    ....
  69. ncbi Accuracy of intra-articular injection of the glenohumeral joint: a cadaveric study
    Paul M Sethi
    Orthopedic and Neurosurgical Specialists, Greenwich, Conn 06830, USA
    Orthopedics 29:149-52. 2006
    ..75 positive predictive value. The posterior approach had a 50% accuracy rate and a .67 positive predictive value. Anterior injections produce a higher rate of accuracy than posterior injections...
  70. ncbi Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model
    M Mihara
    Product Research Department, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
    Osteoarthritis Cartilage 15:543-9. 2007
    ..We examined the effects of nonsteroidal anti-inflammatory drug (NSAID) and intra-articular injections of sodium hyaluronate (HA) on cartilage degeneration in rabbit knee osteoarthritis (OA) model induced by partial meniscectomy...
  71. ncbi Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study
    Robert S Salk
    Northern California Foot and Ankle Center, 45 Castro Street, Suite 315, San Francisco, CA 94114, USA
    J Bone Joint Surg Am 88:295-302. 2006
    ....
  72. ncbi Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels
    Erik af Klint
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 52:3880-9. 2005
    ..To investigate whether intraarticular (IA) glucocorticoid (GC) therapy diminishes synovial cell infiltration, vascularity, expression of proinflammatory cytokines, and adhesion molecule levels in patients with chronic arthritides...
  73. ncbi The efficacy of subacromial corticosteroid injection in the treatment of rotator cuff disease: A systematic review
    Michael C Koester
    Orthopaedic Healthcare Northwest, Eugene, OR, USA
    J Am Acad Orthop Surg 15:3-11. 2007
    ..This systematic review of the available literature indicates that there is little reproducible evidence to support the efficacy of subacromial corticosteroid injection in managing rotator cuff disease...
  74. ncbi The symptomatic effects of intra-articular administration of hylan G-F 20 on osteoarthritis of the hip: clinical data of 6 months follow-up
    Alberto Migliore
    Research Center S Pietro Hospital, Fatebenefratelli AFaR, Via Cassia 600, 00189 Rome, Italy
    Clin Rheumatol 25:389-93. 2006
    ..The present observation suggests the potentiality for the safety and efficacy of hylan G-F 20 injected under US guidance in patients with symptomatic hip OA. Further controlled studies are needed...
  75. ncbi A cost consequences analysis of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care
    M James
    Centre for Health Planning and Management, Keele University, Keele, Staffordshire ST5 5BG, UK
    Rheumatology (Oxford) 44:1447-51. 2005
    ....
  76. ncbi MR arthrography of the glenohumeral joint: modified posterior approach without imaging guidance
    Onofrio A Catalano
    Department of Radiology, AO G Rummo, Via Provinciale 93, Beltiglio, BN, 82010, Italy
    Radiology 242:550-4. 2007
    ..The mean extension of extravasation was 15 mm. Image quality was not compromised, and no gas bubbles were detected. The procedure was successful in all patients, with no complications...
  77. ncbi Successful nonoperative management of chronic osteoarthritis pain of the knee: safety and efficacy of retreatment with intra-articular hyaluronans
    Mark Pagnano
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Osteoarthritis Cartilage 13:751-61. 2005
    ..Five intra-articular hyaluronan products are approved in the US. No systematic review of the safety and efficacy of their chronic use has been reported...
  78. pmc Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy
    J Adriaansen
    Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 64:1677-84. 2005
    ..Gene therapy of the joint has great potential as a new therapeutic approach for the treatment of rheumatoid arthritis (RA). The vector chosen is of crucial importance for clinical success...
  79. ncbi Accuracy of subacromial injection: anterolateral versus posterior approach
    Peter V Mathews
    The Permanente Medical Group, Roseville, CA 95661, USA
    J Shoulder Elbow Surg 14:145-8. 2005
    ..The anterolateral approach may place injected material medial to the medial bursal boundary, and fluoroscopy may not accurately assess this placement...
  80. ncbi Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice
    Ferry Kemper
    Klinik Lohrey, Orthopädie und Rheumatologie, Bad Soden Salmünster, Germany
    Curr Med Res Opin 21:1261-9. 2005
    ..To determine the tolerability and short-term effectiveness of hylan G-F 20 (Synvisc) in patients with symptomatic osteoarthritis (OA) of the knee in standard clinical practice...
  81. ncbi [Intra-articular treatment with Hylan G-F 20 under ultrasound guidance in hip osteoarthritis. Clinical results after 12 months follow-up]
    A Migliore
    Dipartimento di Medicina Interna, Ospedale S Pietro Fatebenefratelli, Via Cassia, 600 00192 Rome
    Reumatismo 57:36-43. 2005
    ..Viscosupplementation is a promising approach for hip OA, although further and wider studies are wanted to determine how long the beneficial effect lasts, and what is the optimal number of injections to administer...
  82. ncbi [18-month observational study on efficacy of intraarticular hyaluronic acid (Hylan G-F 20) injections under ultrasound guidance in hip osteoarthritis]
    Alberto Migliore
    U O S di Reumatologia, S Pietro Fatebenefratelli Ospedale, 00189 Roma
    Reumatismo 58:39-49. 2006
    ..To evaluate the efficacy and the tolerability of viscosupplementation (VS) with hyaluronic acid (Hylan GF 20) in a cohort of 36 patients affected by hip osteoarthritis through a 18 months follow-up...
  83. pmc Joint and soft tissue injections in the community: questionnaire survey of general practitioners' experiences and attitudes
    G J Gormley
    Department of General Practice, Queens University Belfast, Dunluce Health Centre, 1 Dunluce Avenue, Belfast, Northern Ireland BT9 7HR
    Ann Rheum Dis 62:61-4. 2003
    ..To investigate the numbers and types of joint and soft tissue injections performed by general practitioners (GPs) and to explore attitudes to training in joint and soft tissue injection and perceived barriers to performing injections...
  84. ncbi Role of hylan G-F 20 in treatment of osteoarthritis of the hip joint
    Vijay B Vad
    Department of Rehabilitation Medicine, Cornell University Medical Center, New York, NY, USA
    Arch Phys Med Rehabil 84:1224-6. 2003
    ..To study the efficacy of hylan G-F 20 in the treatment of osteoarthritis (OA) of the hip joint...
  85. ncbi Intraarticular corticosteroids, supervised physiotherapy, or a combination of the two in the treatment of adhesive capsulitis of the shoulder: a placebo-controlled trial
    Simon Carette
    Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Arthritis Rheum 48:829-38. 2003
    ..To compare the efficacy of a single intraarticular corticosteroid injection, a supervised physiotherapy program, a combination of the two, and placebo in the treatment of adhesive capsulitis of the shoulder...
  86. ncbi Patient's assessment of discomfort during MR arthrography of the shoulder
    C A Binkert
    Department of Radiology, University Hospital Balgrist, Zurich, Switzerland
    Radiology 221:775-8. 2001
    ....
  87. ncbi A safe, reliable method of carpal tunnel injection
    N R Kay
    Department of Orthopaedic Surgery, Royal Hallamshire Hospital, Sheffield, England
    J Hand Surg Am 17:1160-1. 1992
    ..We present a new method of carpal tunnel injection based on anatomic dissections. We have used this technique successfully for more than 10 years, and there have been no cases of median nerve injury...
  88. ncbi Hip osteoarthritis: short-term efficacy and safety of viscosupplementation by hylan G-F 20. An open-label study in 22 patients
    Olivier Brocq
    Rheumatology Department, CHU l Archet 1, Nice, France
    Joint Bone Spine 69:388-91. 2002
    ..We studied the short-term safety and efficacy of intraarticular hylan G-F 20 (Synvisc) in patients with symptomatic hip osteoarthritis...
  89. ncbi Accuracy of needle placement into the intra-articular space of the knee
    Douglas W Jackson
    Southern California Center for Sports Medicine, Long Beach 90806, USA
    J Bone Joint Surg Am 84:1522-7. 2002
    ..In the absence of a knee effusion, reproducible needle placement into the intra-articular space presents a challenge to the clinician...
  90. ncbi Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent?
    Peter Ghosh
    Institute of Bone and Joint Research, Department of Surgery, University of Sydney, Royal North Shore Hospital, New South Wales, Australia
    Semin Arthritis Rheum 32:10-37. 2002
    ..All these physicochemical and biologic properties of HA have been shown to be molecular weight (MW) dependent...
  91. pmc Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action
    Larry W Moreland
    University of Alabama at Birmingham, Birmingham, AL, USA
    Arthritis Res Ther 5:54-67. 2003
    ..Many of the physiological effects of exogenous HA may be a function of its molecular weight. Several physiological effects probably contribute to the mechanisms by which HA and hylans exert their clinical effects in knee OA...
  92. pmc A pragmatic randomised controlled trial of local corticosteroid injection and physiotherapy for the treatment of new episodes of unilateral shoulder pain in primary care
    E M Hay
    Staffordshire Rheumatology Centre, The Haywood, Burslem, Stoke on Trent, North Staffordshire ST6 7AG, UK
    Ann Rheum Dis 62:394-9. 2003
    ..To compare the long term effectiveness of local steroid injections administered by general practitioners with practice based physiotherapy for treating patients presenting in primary care with new episodes of unilateral shoulder pain...
  93. ncbi Efficacy and safety of viscosupplementation by ultrasound-guided intra-articular injection in osteoarthritis of the hip
    A Migliore
    Department of Internal Medicine, S Pietro Fatebenefratelli Hospital, Rome, Italy
    Osteoarthritis Cartilage 11:305-6. 2003
  94. ncbi Diagnostic and therapeutic injection of the shoulder region
    Alfred F Tallia
    Department of Family Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Am Fam Physician 67:1271-8. 2003
    ..The proper technique, choice and quantity of pharmaceuticals, and appropriate follow-up are essential for effective outcomes...
  95. ncbi Is there a place for intra-articular hyaluronate in osteoarthritis of the knee?
    J Kirwan
    University Division of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Knee 8:93-101. 2001
    ..Current evidence suggests that viscosupplements probably provide a similar level of pain relief to glucocorticoids and do so for several months, but the onset is slower, and there is the potential for local adverse reactions...
  96. ncbi Thoracic zygapophyseal joint pain patterns. A study in normal volunteers
    P Dreyfuss
    Neuro Skeletal Center, Tyler, Texas
    Spine (Phila Pa 1976) 19:807-11. 1994
    ..Nine asymptomatic volunteers underwent 40 provocative intra-articular injections of the thoracic zygapophyseal joints...
  97. pmc Hyaluronic acid injections for knee osteoarthritis. Systematic review of the literature
    Anita Aggarwal
    Department of Family Medicine, Queen s University, Kingston, Ont
    Can Fam Physician 50:249-56. 2004
    ..To determine whether viscosupplementation with intra-articular hyaluronic acid (HA) injections improves pain and function in patients with osteoarthritis (OA) in their knees...
  98. ncbi Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit
    D Uebelhart
    Department of Clinical Neurosciences and Dermatology, University Hospital of Geneva, Switzerland
    Osteoarthritis Cartilage 6:6-13. 1998
    ....
  99. ncbi Clinical features of patients with pain stemming from the lumbar zygapophysial joints. Is the lumbar facet syndrome a clinical entity?
    A C Schwarzer
    Faculty of Medicine, University of Newcastle, Australia
    Spine (Phila Pa 1976) 19:1132-7. 1994
    ..This study is a prospective cross-sectional analytic study...
  100. ncbi Sonographically guided glenohumeral joint injection
    Richard B Zwar
    Department of Radiology, Austin Health, 145 163 Studley Rd, Heidelberg, Victoria 3084, Australia
    AJR Am J Roentgenol 183:48-50. 2004
  101. ncbi An open-label study of a second course of hylan G-F 20 for the treatment of pain associated with knee osteoarthritis
    David D Waddell
    Orthopedic Specialists of Louisiana, Inc, Shreveport, LA 71103, USA
    Curr Med Res Opin 19:499-507. 2003
    ..To evaluate the efficacy and tolerability of a second course of hylan G-F 20 for the treatment of osteoarthritic knee pain in patients who experienced a clinical benefit with an initial course of therapy...

Research Grants46

  1. N-Acetylglucosamine Treatment of Osteoarthritis
    Yoshitaka Ichikawa; Fiscal Year: 2003
    ..2. Assess therapeutic efficacy of GIcNAc formulations in rabbits with experimentally induced OA. These studies have the potential to provide the basis for a safe and effective chondroprotective therapy for OA. ..
  2. Tribosupplementation of Injured Joints
    Gregory D Jay; Fiscal Year: 2013
    ..The PI is also a practicing emergency physician and already collaborates with the sub-contract Co-I, who has also performed several large animal studies to date. ..
  3. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..The results will establish the capacity of HA/TGF-B to sustain proteoglycan syntheses to facilitate repair of osteoarthritic articular cartilage...
  4. TARGETED NANOTHERAPY IN THE TREATMENT OF INFLAMMATORY ARTHRITIS
    CHRISTINE T PHAM; Fiscal Year: 2012
    ..In conjunction, we will develop MR molecular imaging technologies based on targeted nanoparticles to track early therapeutic responses in a rabbit model of inflammatory arthritis. ..
  5. HYALURONIC ACID AND ARTHRITIS
    ENDRE BALAZS; Fiscal Year: 1980
    ....
  6. Intraarticular injection of polyglucosamine for knee OA
    MAURIZIO CATTANEO; Fiscal Year: 2002
    ..3) Examine the extent of lesions in a blind fashion using morphological, histological and biochemical evaluations. ..
  7. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
    ..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. [unreadable] [unreadable] [unreadable]..
  8. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  9. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  10. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  11. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  12. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  13. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Gene therapy for treatment of craniofacial dysplasia
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
  15. NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENT
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..abstract_text> ..
  16. Does peripheral localized chronic inflammation predispose to neurodegeneration?
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Recombinant FIV vectors for the delivery of siRNA therapy to joints
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Functional Impact of PENS for 65+ Chronic Low Back Pain
    Debra Weiner; Fiscal Year: 2006
    ....
  19. Novel Nanostructured Calcium Phosphate for Gene Delivery to Bone
    Christopher Evans; Fiscal Year: 2005
    ..2. To evaluate the ability of nCaP-vector constructs to enhance osteogenic responses in vivo. ..
  20. Sympathetic Outflow to Catecholamine Storage Vesicles
    DANIEL O CONNOR; Fiscal Year: 2006
    ..Finally, these photoprotein and cDNA reagents can be widely employed by other investigators in elucidating biosynthetic, trafficking, and ion flux events in the sympathochromaffin system. ..
  21. Rheumatoid Arthritis Induction Trial (RAITMAT)
    Larry Moreland; Fiscal Year: 2007
    ..This will lead to the development of the proposed Rheumatoid Arthritis Induction Trial with MTX and Anti-TNF Therapy (RAITMAT). [unreadable] [unreadable] [unreadable] [unreadable]..
  22. Central trigeminal mechanisms in ocular pain
    DAVID BEREITER; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  23. SPECIALIZED CENTER OF RESEARCH IN OSTEOARTHRITIS
    Theodore Oegema; Fiscal Year: 2007
    ..e. markers) outcome measures will be collected. The proposed studies will encompass five individual yet overlapping projects supported by two Core Facilities. ..
  24. Pulsus Paradoxus Monitor
    Gregory Jay; Fiscal Year: 2005
    ..Future Phase 2 activities could include prospective PP threshold testing in the emergency department and home monitoring of selected asthmatic patients, both of which would impact efficient clinical resource utilization. ..
  25. Osteopuncture for OA-Associated Knee Pain & Disability
    Debra Weiner; Fiscal Year: 2005
    ..In addition, mechanisms of action will be explored, and the impact of osteopuncture on health care costs determined. ..
  26. EVALULATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM
    Richard Coutts; Fiscal Year: 2001
    ..The goal is to develop an implant that will consistently and predictably produce repairs of full-thickness articular cartilage defects that will function as well as normal cartilage. ..
  27. Delivery of Therapeutic Genes to Osteoarthritic Joints
    Christopher Evans; Fiscal Year: 2002
    ....
  28. IMMUNOPROBES FOR LUBRICIN FROM HUMAN SYNOVIAL FLUID
    Gregory Jay; Fiscal Year: 2003
    ..This principal goal of this investigation is to develop new immunological probes and with these identify the concentration of lubricin in synovial fluid extracted from healthy and arthritic human joints. ..
  29. Localization and activation of protease receptor PAR1
    CANDICE JUNGE; Fiscal Year: 2002
    ..Because tPA is currently approved for stroke, these studies may lead to a possible adjunct therapy that enhances tPA?s beneficial effects. ..
  30. Growth factor gene mediated cartilage repair
    LAURIE GOODRICH; Fiscal Year: 2004
    ..abstract_text> ..
  31. PROTEOGLYCANS/MATRIX ASSEMBLY IN REGENERATING CARTILAGE
    Theodore Oegema; Fiscal Year: 2003
    ....
  32. AAOS/NIH Mulit-Year Research Symposia for 2005-2009
    Christopher Evans; Fiscal Year: 2005
    ....
  33. CLINICAL RESEARCH TRAINING PROGRAM
    Larry Moreland; Fiscal Year: 2004
    ..abstract_text> ..
  34. Lanthanides as Novel Anti-Arthritic Agents
    Christopher Evans; Fiscal Year: 2004
    ..A successful outcome to these studies will have identified the basis for a potential new, very inexpensive anti-rheumatic agent whose mode of action differs from that of existing drugs. ..
  35. Inhibition of NF-KB to Facilitate Islet Transplantation
    Paul Robbins; Fiscal Year: 2003
    ..The successful completion of the proposed studies should determine if NF-kB inhibition in islets by peptide and gene mediated transduction is able to improve islet viability prior to and post-transplantation. ..
  36. 2008 Viral Vectors for Gene Therapy, The Science of Gordon Research Conference
    Paul Robbins; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  37. REGULATION OF TRANSCRIPTION BY THE RB ANTIONCOGENE
    Paul Robbins; Fiscal Year: 2002
    ..The experiments described in the proposal are expected to provide important insights into the mechanism of how RB and cyclin D1 function to regulate transcription directly, cell differentiation, and tumorigenesis. ..
  38. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..We further postulate that ES improves glenohumeral stability by facilitating motor recovery. Thus we will evaluate the effects of these treatments on objective measures of poststroke motor recovery. ..
  39. AOSSM Post-Joint Injury Osteoarthritis Conference
    Constance Chu; Fiscal Year: 2008
    ..This symposium will bring doctors and scientists together to develop research plans to find new methods to prevent this from happening. [unreadable] [unreadable] [unreadable] [unreadable]..
  40. An RCT for Treating Carpometacarpal Osteoarthritis
    LISA MANDL; Fiscal Year: 2008
    ..This will fill a gap in the literature, and provide evidence-based data for intra-articular corticosteroids, the present use of which is based only on anecdotal and conventional practices. ..
  41. Chondroprotection mediated by GFAT gene transfer
    Jean Noel Gouze; Fiscal Year: 2008
    ..If successfully completed, this study will lead to further insight to the biological effects of glucosamine on arthritis and perhaps the development of a novel chondroprotective strategy for the treatment of OA. ..
  42. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2009
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  43. Electrical stimulation for upper limb recovery in stroke
    John Chae; Fiscal Year: 2008
    ..2. Assess the effect of NMES on upper limb activity limitation. 3. Assess the effect of NMES on central motor processing. 4. Assess the effect of adding cognitive input during NMES therapy. ..
  44. CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE
    Constance Chu; Fiscal Year: 2002
    ..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..
  45. ELECTROSTIMULATION FOR STROKE REHAB: EFFECTS & MECHANISM
    John Chae; Fiscal Year: 2002
    ..Finally, techniques developed for assessing central motor function may be useful for evaluating other interventions directed at stroke rehabilitation. ..
  46. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2004
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..