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Genomes and Genes
| dietSummarySummary: Regular course of eating and drinking adopted by a person or animal. This does not include DIET THERAPY, a specific diet prescribed in the treatment of a disease. Top Publications
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Publications
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspringSheau Fang Ng
Department of Pharmacology, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
Nature 467:963-6. 2010..Although the detrimental impacts of diet-induced maternal obesity on adiposity and metabolism in offspring are well established, the extent of any ..
Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research GroupF M Sacks
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
N Engl J Med 344:3-10. 2001..effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop Hypertension (DASH) diet, which is rich in vegetables, fruits, and low-fat dairy products, in persons with and in those without hypertension.
Mechanisms underlying the resistance to diet-induced obesity in germ-free miceFredrik Backhed
Center for Genome Sciences and Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
Proc Natl Acad Sci U S A 104:979-84. 2007..GF) animals are protected against the obesity that develops after consuming a Western-style, high-fat, sugar-rich diet. Their persistently lean phenotype is associated with increased skeletal muscle and liver levels of phosphorylated ..
Obesity in children and young people: a crisis in public healthT Lobstein
IASO International Obesity TaskForce, 231 North Gower Street, London NW1 2NS, UK
Obes Rev 5:4-104. 2004
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control studySalim Yusuf
Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
Lancet 364:937-52. 2004..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition CommitteeAlice H Lichtenstein
Circulation 114:82-96. 2006Improving diet and lifestyle is a critical component of the American Heart Association's strategy for cardiovascular disease risk reduction in the general population. This document presents recommendations designed to meet this objective...
Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterationsErica D Sonnenburg
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 141:1241-52. 2010The intestinal microbiota impacts many facets of human health and is associated with human diseases. Diet impacts microbiota composition, yet mechanisms that link dietary changes to microbiota alterations remain ill-defined...
The continuing epidemics of obesity and diabetes in the United StatesA H Mokdad
Data Management Division, National Immunization Program, Centers for Disease Control and Prevention, MS E62, 1600 Clifton Rd, NE, Atlanta, GA 30333, USA
JAMA 286:1195-200. 2001..Recent reports show that obesity and diabetes have increased in the United States in the past decade...
Can gestational weight gain be modified by increasing physical activity and diet counseling? A meta-analysis of interventional trialsIna Streuling
Division of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilians University of Munich, Munich, Germany
Am J Clin Nutr 92:678-87. 2010..It is therefore of interest whether GWG can be modified by an intervention combining dietary counseling and physical activity...
Origins and evolution of the Western diet: health implications for the 21st centuryLoren Cordain
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
Am J Clin Nutr 81:341-54. 2005There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry approximately 10000 y ago occurred too recently on ..
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeY Nakashima
Department of Pathology, University of Washington, Seattle 98195
Arterioscler Thromb 14:133-40. 1994..In the present study, the animals were fed either chow or a high-fat, Western-type diet and examined at ages ranging from 6 to 40 weeks...
Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular diseasePenny M Kris-Etherton
Circulation 106:2747-57. 2002
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesityCarey N Lumeng
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Diabetes 56:16-23. 2007..We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory properties compared with resident tissue ATMs...
Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequencyAngela M Hancock
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 107:8924-30. 2010..This provides genome-wide evidence for selection due to changes in ecoregion, diet, and subsistence...
Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1Gizem Rizki
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
J Lipid Res 47:2280-90. 2006..MCD feeding also induces hepatic steatosis, by an independent mechanism. Viewed together, these two disparate consequences of MCD feeding (weight loss and hepatic steatosis) give the appearance of an unusual form of lipodystrophy...
Systematic review of school-based interventions that focus on changing dietary intake and physical activity levels to prevent childhood obesity: an update to the obesity guidance produced by the National Institute for Health and Clinical ExcellenceT Brown
School of Health and Social Care, University of Teesside, Middlesbrough, UK
Obes Rev 10:110-41. 2009..One of three diet studies, five of 15 physical activity studies and nine of 20 combined diet and physical activity studies ..
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic isletsIonel Sandovici
Metabolic Research Laboratories, Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, United Kingdom
Proc Natl Acad Sci U S A 108:5449-54. 2011..One such factor that is known to play an important role in determining long-term metabolic health is diet during critical periods of development...
Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse modelsE F Murphy
Alimentary Pharmabiotic Centre, University College Cork, Ireland
Gut 59:1635-42. 2010..However, a causal relationship is unproven and contributory variables include diet, genetics and age...
Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) studyCarlos A Gonzalez
Unit of Nutrition, Environment and Cancer, Programme of Epidemilogical Cancer Research, Institut Catala d Oncologia, Av Gran Via S N, Km 2 7, 08907 L Hospitalet, Barcelona, Spain
Eur J Cancer 46:2555-62. 2010..C, some carotenoids, retinol and α-tocopherol, high intake of cereal fibre and high adhesion to Mediterranean diet, while red and processed meat were associated with increased risk...
A central role for JNK in obesity and insulin resistanceJiro Hirosumi
Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Nature 420:333-6. 2002..Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics...
A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male ratsMagali Lacroix
, INA PG, 16 rue Claude Bernard, 75231 Paris Cedex 05, France
Am J Physiol Regul Integr Comp Physiol 287:R934-42. 2004..However, the long-term effects of a high-protein diet on a broad range of parameters have not been investigated...
High-fat diet determines the composition of the murine gut microbiome independently of obesityMarie A Hildebrandt
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Gastroenterology 137:1716-24.e1-2. 2009The composition of the gut microbiome is affected by host phenotype, genotype, immune function, and diet. Here, we used the phenotype of RELMbeta knockout (KO) mice to assess the influence of these factors.
Amino-acid imbalance explains extension of lifespan by dietary restriction in DrosophilaRichard C Grandison
Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
Nature 462:1061-4. 2009..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet.
Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: a population-based prospective cohort study of 57,053 men and women in DenmarkAnne Tjønneland
Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
Scand J Public Health 35:432-41. 2007b>Diet is considered an important aspect of lifestyle related to cancer development. To contribute further knowledge within this field a Danish prospective cohort study "Diet, Cancer and Health" has been initiated...
Changes in diet and lifestyle and long-term weight gain in women and menDariush Mozaffarian
Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
N Engl J Med 364:2392-404. 2011..Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain...
Brown fat and the myth of diet-induced thermogenesisLeslie P Kozak
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Cell Metab 11:263-7. 2010..Studies in obese rats and mice lacking UCP1 indicate that diet-induced thermogenesis by BAT is unlikely.
The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on dietKaren Lock
European Centre on Health of Societies in Transition, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
Bull World Health Organ 83:100-8. 2005....
How host-microbial interactions shape the nutrient environment of the mammalian intestineLora V Hooper
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Annu Rev Nutr 22:283-307. 2002..These and other studies underscore the importance of understanding precisely how nutrient metabolism serves to establish and sustain symbiotic relationships between mammals and their bacterial partners...
Maternal vitamin D status determines bone variables in the newbornH T Viljakainen
Department of Applied Chemistry and Microbiology, Division of Nutrition, P O Box 66, University of Helsinki, FI 00014 Helsinki, Finland
J Clin Endocrinol Metab 95:1749-57. 2010..Maternal vitamin D status may program neonatal skeletal development. The objective here was to determine the association of mothers' vitamin D status with bone variables of their newborns...
Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populationsYin Ruixing
Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People s Republic of China
J Lipid Res 48:2673-81. 2007..The aim of this study was to compare the effects of demography, diet, and lifestyle on serum lipid levels between the Bai Ku Yao and Han populations...
Folate and colorectal cancer: an evidence-based critical reviewYoung In Kim
Department of Medicine and Nutritional Sciences, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
Mol Nutr Food Res 51:267-92. 2007..Based on the lack of compelling supportive evidence and on the potential tumor-promoting effect, routine folic acid supplementation should not be recommended as a chemopreventive measure against CRC at present...
Randomized trial of a behavioral intervention to prevent excessive gestational weight gain: the Fit for Delivery StudySuzanne Phelan
Departments of Kinesiology, California Polytechnic State University, San Luis Obispo, 93407 0386, USA
Am J Clin Nutr 93:772-9. 2011....
Diet, gut microbiota and immune responsesKendle M Maslowski
Garvan Institute of Medical Research, and the Cooperative Research Centre for Asthma and Airways, Sydney, Australia
Nat Immunol 12:5-9. 2011The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesisHerbert Tilg
Christian Doppler Research Laboratory for Gut Inflammation, Medical University Innsbruck, Innsbruck, Austria
Hepatology 52:1836-46. 2010..Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH...
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of ageCarlos A Camargo
Center for D receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Clin Nutr 85:788-95. 2007..Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown...
Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiomePeter J Turnbaugh
Center for Genome Sciences, Washington University, St Louis, MO 63108, USA
Cell Host Microbe 3:213-23. 2008We have investigated the interrelationship between diet, gut microbial ecology, and energy balance using a mouse model of obesity produced by consumption of a prototypic Western diet...
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesityDouglas Osei-Hyiaman
National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 115:1298-305. 2005..CB(1) (-/-) mice are resistant to diet-induced obesity even though their caloric intake is similar to that of wild-type mice, suggesting that ..
Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescentsMichael I Goran
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 88:1417-27. 2003..Therefore, the purpose of this paper is to review the pathophysiology of type 2 diabetes and cardiovascular risk in obese children and adolescents...
Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factorsGoodarz Danaei
Harvard School of Public Health, Boston, MA 02115, USA
Lancet 366:1784-93. 2005..INTERPRETATION: Reduction of exposure to key behavioural and environmental risk factors would prevent a substantial proportion of deaths from cancer...
Preventing excessive weight gain during pregnancy - a controlled trial in primary health careT I Kinnunen
UKK Institute for Health Promotion Research, Tampere, Finland
Eur J Clin Nutr 61:884-91. 2007To investigate whether individual counselling on diet and physical activity during pregnancy can have positive effects on diet and leisure time physical activity (LTPA) and prevent excessive gestational weight gain.
Diet, physical activity, and sedentary behaviors as risk factors for overweight in adolescenceKevin Patrick
University of California, San Diego, San Diego State University, and Kaiser Permanente Medical Group, San Diego, CA 92093 0811, USA
Arch Pediatr Adolesc Med 158:385-90. 2004..The proportion of overweight adolescents has increased, but the behavioral risk factors for overweight youth are not well understood...
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Norikazu Maeda
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
Nat Med 8:731-7. 2002..The KO mice exhibited severe diet-induced insulin resistance with reduced insulin-receptor substrate 1 (IRS-1)-associated phosphatidylinositol 3 ..
The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factorsGoodarz Danaei
Harvard School of Public Health, Boston, MA, USA
PLoS Med 6:e1000058. 2009....
Sirt1 protects against high-fat diet-induced metabolic damagePaul T Pfluger
Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
Proc Natl Acad Sci U S A 105:9793-8. 2008..Mammalian Sirt1 is a protein deacetylase that has been involved in resveratrol-mediated protection from high-fat diet-induced metabolic damage, but direct proof for the implication of Sirt1 has remained elusive...
The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic micePeter J Turnbaugh
Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
Sci Transl Med 1:6ra14. 2009b>Diet and nutritional status are among the most important modifiable determinants of human health. The nutritional value of food is influenced in part by a person's gut microbial community (microbiota) and its component genes (microbiome)...
Does social class predict diet quality?Nicole Darmon
INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, France
Am J Clin Nutr 87:1107-17. 2008A large body of epidemiologic data show that diet quality follows a socioeconomic gradient...
Intensive lifestyle changes for reversal of coronary heart diseaseD Ornish
Department of Medicine, California Pacific Medical Center, San Francisco, USA
JAMA 280:2001-7. 1998..The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to regression of coronary atherosclerosis after 1 year...
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humansBrian D Muegge
Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
Science 332:970-4. 2011..of bacterial 16S ribosomal RNA genes to gain an understanding of how microbial communities adapt to extremes of diet. We sampled fecal DNA from 33 mammalian species and 18 humans who kept detailed diet records, and we found that the ..
Sodium in the Finnish diet: 20-year trends in urinary sodium excretion among the adult populationT Laatikainen
Department of Epidemiology and Health Promotion, National Public Health Institute KTL, Helsinki, Finland
Eur J Clin Nutr 60:965-70. 2006..In Finland, cross-sectional population surveys to monitor cardiovascular risk factors have been carried out since the 1970s. The main aim of this paper is to present trends in urinary sodium and potassium excretion from 1979 to 2002...
Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trialLawrence J Appel
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
JAMA 289:2083-93. 2003..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP...
Neighborhood environments: disparities in access to healthy foods in the U.SNicole I Larson
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
Am J Prev Med 36:74-81. 2009..S. This article reviews research relating to the presence, nature, and implications of neighborhood differences in access to food...
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2David B Savage
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Clin Invest 116:817-24. 2006..We used a diet-induced rat model of nonalcoholic fatty liver disease (NAFLD) and hepatic insulin resistance to explore the impact ..
Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancerManon van Engeland
The Research Institute GROW, Department of Pathology, University Maastricht, 6200 MD Maastricht, The Netherlands
Cancer Res 63:3133-7. 2003..085). Despite the size limitations of this study, these data suggest that folate and alcohol intake may be associated with changes in promoter hypermethylation in CRC...
Does chocolate reduce blood pressure? A meta-analysisKarin Ried
Discipline of General Practice, The University of Adelaide, Adelaide, SA 5005, Australia
BMC Med 8:39. 2010..Recently, several additional trials have been conducted with conflicting results. Our study summarises current evidence on the effect of flavanol-rich cocoa products on blood pressure in hypertensive and normotensive individuals...
Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanismsYiying Zhang
Department of Pediatrics, Division of Molecular Genetics, Columbia University, New York, NY 10032, USA
Diabetes 56:1647-54. 2007..leucine intake via leucine-containing drinking water in mice with free excess to either a rodent chow or a high-fat diet (HFD)...
An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approachGertruud Cm Bakker
TNO Quality of Life, Business Unit Biosciences, Zeist, The Netherlands
Am J Clin Nutr 91:1044-59. 2010..Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development...
Linking long-term dietary patterns with gut microbial enterotypesGary D Wu
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 334:105-8. 2011b>Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals...
Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunctionWai Mun Loke
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Arterioscler Thromb Vasc Biol 30:749-57. 2010....
Stable isotope evidence for increasing dietary breadth in the European mid-Upper PaleolithicM P Richards
Department of Archaeological Science, University of Bradford, Bradford, West Yorkshire, BD7 1DP, United Kingdom
Proc Natl Acad Sci U S A 98:6528-32. 2001....
Optimal diets for prevention of coronary heart diseaseFrank B Hu
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
JAMA 288:2569-78. 2002..Thus, identification of the dietary changes that most effectively prevent CHD is critical...
Dominant and diet-responsive groups of bacteria within the human colonic microbiotaAlan W Walker
Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, UK
ISME J 5:220-30. 2011..Volunteers were provided successively with a control diet, diets high in resistant starch (RS) or non-starch polysaccharides (NSPs) and a reduced carbohydrate weight loss (..
Two neurons mediate diet-restriction-induced longevity in C. elegansNicholas A Bishop
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 447:545-9. 2007..However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated...
Total dietary carbohydrate, sugar, starch and fibre intakes in the European Prospective Investigation into Cancer and NutritionA E Cust
Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France
Eur J Clin Nutr 63:S37-60. 2009..To describe dietary carbohydrate intakes and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study...
Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United StatesRegan L Bailey
Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA
Am J Clin Nutr 92:383-9. 2010..Unmetabolized serum folic acid (UMFA) has been detected in adults. Previous research indicates that high folic acid intakes may be associated with risk of cancer...
Changing patterns of diet, physical activity and obesity among urban, rural and slum populations in north IndiaK Yadav
Comprehensive Rural Health Services Project, Ballabgarh, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India
Obes Rev 9:400-8. 2008..Non-communicable disease control strategy needs to address urbanization and warrants gender sensitive strategies specifically targeting women...
The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implicationsChizuru Nishida
Department of Nutrition for Health and Development, WHO, Geneva, Switzerland
Public Health Nutr 7:245-50. 2004
Association of fruit and vegetable intake with cardiovascular risk factors in urban south IndiansGanesan Radhika
Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, 4 Conran Smith Road, Gopalapuram, Chennai, India
Br J Nutr 99:398-405. 2008..Increased intake of fruits and vegetables could play a protective role against CVD in Asian Indians who have high rates of premature coronary artery disease...
Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndromeT Dreja
Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
Diabetologia 53:309-20. 2010..We therefore investigated islets from the polygenic New Zealand mouse (NZL) model of diet-induced beta cell dysfunction to identify novel genes and pathways that may play a role in the pathogenesis of ..
Estimating glomerular filtration rate in HIV-infected adults in Africa: comparison of Cockcroft-Gault and Modification of Diet in Renal Disease formulaeWolfgang Stöhr
MRC Clinical Trials Unit, London, UK
Antivir Ther 13:761-70. 2008Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulae are recommended for glomerular filtration rate (GFR) estimation, but neither has been validated or directly compared longitudinally in HIV-infected patients or ..
Empirically derived eating patterns using factor or cluster analysis: a reviewP K Newby
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Nutr Rev 62:177-203. 2004..Although the research considered herein has created a meaningful body of literature, refining both the factor and cluster analysis methods will help to further establish eating patterns as a sound dietary assessment method...
Weight, physical activity, diet, and prognosis in breast and gynecologic cancersAnne McTiernan
Fred Hutchinson Cancer Center, 1100 Fairview Ave North, M4 B874, Seattle, WA, 98109, USA
J Clin Oncol 28:4074-80. 2010b>Diet, physical activity, and weight may affect prognosis among women who are diagnosed with breast or gynecologic cancer...
DNA damage and repair activity after broccoli intake in young healthy smokersPatrizia Riso
Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, sezione Nutrizione Umana, Universita degli Studi di Milano, 20133 Milano, Italy
Mutagenesis 25:595-602. 2010..Twenty-seven young healthy smokers consumed a portion of steamed broccoli (250 g/day) or a control diet for 10 days each within a crossover design with a washout period. Blood was collected before and after each period...
Analysis of Australian fur seal diet by pyrosequencing prey DNA in faecesBruce E Deagle
Australian Marine Mammal Centre, Australian Antarctic Division, Tasmania, Australia
Mol Ecol 18:2022-38. 2009..We investigated the diet of Australian fur seals (Arctocephalus pusillus doriferus) by pyrosequencing prey DNA from faeces collected at ..
Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese miceNoriaki Kawanishi
Graduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan
Exerc Immunol Rev 16:105-18. 2010..Therefore, we inveStigated the effect of exercise training on the macrophage phenotypic switch in adipose tissue in high-fat-induced obese mice...
Estimated macronutrient and fatty acid intakes from an East African Paleolithic dietRemko S Kuipers
Department of Laboratory Medicine, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
Br J Nutr 104:1666-87. 2010..result from mismatches between our Paleolithic genome and the rapidly changing environment, including our diet. The objective of the present study was to reconstruct multiple Paleolithic diets to estimate the ranges of ..
Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of womenChristin Heidemann
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02215, USA
Circulation 118:230-7. 2008..The impact of overall dietary patterns that reflect actual eating behaviors on mortality caused by cardiovascular or other chronic diseases is largely unknown...
Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transitionB M Popkin
Department of Nutrition, University of North Carolina, Chapel Hill 27516-3997, USA
Nutr Rev 59:379-90. 2001Undernutrition is being rapidly reduced in India and China. In both countries the diet is shifting toward higher fat and lower carbohydrate content...
Paleolithic nutrition: twenty-five years laterMelvin Konner
Department of Anthropology, Emory University, Atlanta, GA 30306, USA
Nutr Clin Pract 25:594-602. 2010..Much more research needs to be done, but the past quarter century has proven the interest and heuristic value, if not yet the ultimate validity, of the model...
The ecological significance of tool use in New Caledonian crowsChristian Rutz
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Science 329:1523-6. 2010..Bayesian diet-mixing models revealed that a substantial amount of the crows' protein and lipid intake comes from prey obtained ..
Early life risk factors for obesity in childhood: cohort studyJohn J Reilly
University of Glasgow Division of Developmental Medicine, Yorkhill Hospitals, Glasgow G3 8SJ
BMJ 330:1357. 2005..To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom...
Isotopic evidence for diet and subsistence pattern of the Saint-Césaire I Neanderthal: review and use of a multi-source mixing modelHerve Bocherens
Institut des Sciences de l Evolution, UMR 5554, Universite Montpellier 2, Place E Bataillon, F 34095 Montpellier cedex 05, France
J Hum Evol 49:71-87. 2005..The high proportion of very large herbivores, such as woolly rhinoceros and woolly mammoth, in Neanderthal's diet compare to that of the scavenging hyaenas suggests that Neanderthals could not acquire these prey through ..
Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanizationS Yusuf
Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
Circulation 104:2746-53. 2001..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptinB H Hahn
Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
Lupus 19:913-7. 2010..model of multigenic lupus exposed to environmental factors known to accelerate atherosclerosis in humans - high-fat diet with or without injections of the adipokine leptin...
Fruit and vegetables: the unexpected natural answer to the question of osteoporosis prevention?Susan A Lanham-New
Am J Clin Nutr 83:1254-5. 2006
UCP1 deficiency increases susceptibility to diet-induced obesity with ageY Kontani
Department of Aging Intervention, National Institute for Longevity Sciences, 36-3 Gengo, Obu 474-8522, Japan
Aging Cell 4:147-55. 2005..uncoupling protein gene (Ucp1-/- mice) causes increased sensitivity to cold and unexpected resistance to diet-induced obesity at a young age...
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juiceI Erlund
Department of Nutrition, National Public Health Institute KTL, Mannerheimintie 166 F, FIN 00300 Helsinki, Finland
J Nutr 131:235-41. 2001..Orange juice and grapefruit juice contain high amounts of these compounds, and therefore their intake from the diet can be relatively high. No data are available regarding plasma concentrations or plasma kinetics of flavanones...
Contribution of dietary oxalate to urinary oxalate excretionR P Holmes
Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1094, USA
Kidney Int 59:270-6. 2001..An understanding of the actual contribution of dietary oxalate to urinary oxalate excretion is important, as it is potentially modifiable...
Beyond low-density lipoprotein: addressing the atherogenic lipid triad in type 2 diabetes mellitus and the metabolic syndromeRichard W Nesto
Department of Cardiovascular Medicine, Lahey Clinic, Burlington, Massachusetts 02493, USA
Am J Cardiovasc Drugs 5:379-87. 2005....
Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trialBret H Goodpaster
Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, MUH N810, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
JAMA 304:1795-802. 2010....
Essential fatty acids in health and chronic diseaseA P Simopoulos
Center for Genetics, Nutrition and Health, Washington, DC 20009
Am J Clin Nutr 70:560S-569S. 1999Human beings evolved consuming a diet that contained about equal amounts of n-3 and n-6 essential fatty acids...
Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning dietS Rajia
Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
J Neuroendocrinol 22:905-14. 2010..In the present study, we compared the effects of maternal obesity induced by longstanding high-fat diet (HFD) with milder postnatal overfeeding during suckling induced by litter size reduction...
Trigger factors in migraine patientsPatrícia Timy Fukui
Faculdade de Medicina do ABC, São Bernardo, SP, Brazil
Arq Neuropsiquiatr 66:494-9. 2008..Migraine is a chronic neurological disease with several trigger factors, including dietary, hormonal and environmental factors...
Development of the Healthy Eating Index-2005Patricia M Guenther
Center for Nutrition Policy and Promotion, US Department of Agriculture, 3101 Park Center Drive, Suite 1034, Alexandria, VA 22302, USA
J Am Diet Assoc 108:1896-901. 2008The Healthy Eating Index (HEI) is a measure of diet quality as specified by Federal dietary guidance, and publication of the Dietary Guidelines for Americans 2005 necessitated its revision...
Birthplace is associated with more adverse dietary profiles for US-born than for foreign-born Latino adultsKiyah J Duffey
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USA
J Nutr 138:2428-35. 2008..Variation in diet may in part account for the difference in nutrition-related adverse health outcomes observed among USB Hispanics, ..
Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young womenH J Leidy
Noll Physiological Research Center and the Department of Kinesiology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Clin Endocrinol Metab 89:2659-64. 2004..We examined the effects of a 3-month energy deficit-imposing diet and exercise intervention on circulating ghrelin in normal-weight, healthy women...
Products of the colonic microbiota mediate the effects of diet on colon cancer riskStephen J D O'Keefe
University of Pittsburgh, Pittsburgh, PA 15213, USA
J Nutr 139:2044-8. 2009It is estimated that most colon cancers can be attributed to dietary causes. We have hypothesized that diet influences the health of the colonic mucosa through interaction with the microbiota and that it is the milieu interior that ..
Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006Regan L Bailey
Office of Dietary Supplements and the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7517, USA
Am J Clin Nutr 91:231-7. 2010..Previous monitoring efforts did not include folic acid from dietary supplements and are therefore not complete...
A prospective study of intake of fish and marine fatty acids and prostate cancerKatarina Augustsson
Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 12:64-7. 2003..We found that men with high consumption of fish had a lower risk of prostate cancer, especially for metastatic cancer. Marine fatty acids may account for part of the effect, but other factors in fish may also play a role...
Cohort profile: The Boyd Orr cohort--an historical cohort study based on the 65 year follow-up of the Carnegie Survey of Diet and Health (1937-39)Richard M Martin
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
Int J Epidemiol 34:742-9. 2005
Dietary patterns and A1C in Japanese men and womenAkiko Nanri
Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
Diabetes Care 31:1568-73. 2008Dietary patterns in Western populations have been linked to type 2 diabetes, but the role of diet in Japanese remains unclear...
Dietary intake, physical activity and TV viewing as mediators of the association of socioeconomic status with body composition: a cross-sectional analysis of Australian youthJ Dollman
Nutritional Physiology Research Center, University of South Australia, Adelaide, South Australia, Australia
Int J Obes (Lond) 31:45-52. 2007..There is emerging evidence of socioeconomic gradients in adiposity among Australian youth. Behavioral mechanisms for these trends are unexplained...
Research Grants
- Non-Human Primate Model of Gluten-Sensitive EnteropathyKarol Sestak; Fiscal Year: 2009..to celiac disease (CD), and in rhesus monkeys as well as in humans it can be induced by a gluten-containing diet. We recently performed experiments where gluten-sensitive and control macaques were fed gluten- containing diets ..
- Non-Human Primate Model of Gluten-Sensitive EnteropathyKarol Sestak; Fiscal Year: 2010..to celiac disease (CD), and in rhesus monkeys as well as in humans it can be induced by a gluten-containing diet. We recently performed experiments where gluten-sensitive and control macaques were fed gluten- containing diets ..
- SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXINDavid Eaton; Fiscal Year: 2003Numerous studies have demonstrated that biologically active, natural components of the diet may confer resistance to chemical carcinogens via induction and/or inhibition of biotransformation enzymes...
- BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETESBarry E Levin; Fiscal Year: 2010..However, rats selectively bred to develop diet-induced obesity (DIO) on a 31% fat, high sucrose, high energy (HE) diet have an inborn elevation of ARC GK in ..
- Diet and Gastrointestinal Cancer Risk in African Americans and Rural AfricansSTEPHEN JD O apos KEEFE; Fiscal Year: 2010Geographical variations in cancer incidence can be attributed to environmental causes in general, and to diet, in particular...
- Television Advertising and Children's Diet Activity and Obesity PrevalenceLisa Powell; Fiscal Year: 2010Poor diet, inactivity and obesity have been linked to increased risks for a number of chronic diseases including cancer and cardiovascular diseases...
- The Role of Adenosine in Ketogenic Diet TherapySUSAN A contact MASINO; Fiscal Year: 2010..As an alternative, therapy with a high-fat low-carbohydrate (ketogenic) diet can be highly effective in medically-refractory epilepsy, and the mechanisms underlying its success can offer ..
- Cholecystokinin - Role in postprandial gastric motilityHelen E Raybould; Fiscal Year: 2010..are sensed in the gut, the neural pathways activated, and how these may be altered by long term changes in diet leading to increased food intake and obesity...
- EFFECT OF CHRONIC AMYLOSE FEEDING IN ADIPOSITYDANIEL BESSESSEN; Fiscal Year: 2001..The specific aims are: 1) to define the dose-response relationship between the amylose content of the diet and postprandial glycemic/insulinemic response; 2) to measure adipocyte cell size and number in response to a high ..
- Omega-3 fat to reduce risk for breast cancerWANDA ELAINE HARDMAN; Fiscal Year: 2010..The results of epidemiology studies indicate that diet has a profound influence on breast cancer risk...
- Omega 3 fatty acids to reduce risk for breast cancerWANDA HARDMAN; Fiscal Year: 2007..The results of epidemiology studies indicate that diet has a profound influence on breast cancer risk...
- Omega-3 fat to reduce risk for breast cancerWANDA HARDMAN; Fiscal Year: 2009..The results of epidemiology studies indicate that diet has a profound influence on breast cancer risk...
- A Mediterranean Diet in for Colon Cancer PreventionZora Djuric; Fiscal Year: 2009A Mediterranean Diet for Colon Cancer Prevention: Epidemiological and animal studies indicate that the major components of the traditional Cretan-Mediterranean diet have great promise for the prevention of colorectal cancer while ..
- HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINESteven Zeisel; Fiscal Year: 2004..the structural integrity and signaling functions of cell membranes; it is the major source of methyl-groups in the diet, and it directly affects cholinergic neurotransmission, transmembrane signaling and lipid transport/metabolism...
- Economic Contextual Influences on Population Diet and ObesityLisa Powell; Fiscal Year: 2010Poor diet and obesity have been linked to increased risks for a number of chronic diseases including cancer and cardiovascular diseases...
- Economic Contextual Influences on Population Diet and ObesityLisa Powell; Fiscal Year: 2009Poor diet and obesity have been linked to increased risks for a number of chronic diseases including cancer and cardiovascular diseases...
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..for low density lipoprotein (LDL) lowering and CHD risk reduction, but there controversy about other aspects of the diet. We propose to examine the effects of three diets meeting National Cholesterol Education program Step 2 diet ..
- T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced ObesityChristie M Ballantyne; Fiscal Year: 2010..Using a mouse model of obesity induced by a high-fat (HF) diet rich in saturated fatty acids (SFAs), we made the novel finding that T cells are increased and the chemokine ..
- Experimental analysis of price changes and food purchases in obese and lean motheLeonard H Epstein; Fiscal Year: 2010..value of food (RRV) and impulsivity moderate the effects of prices on energy and macronutrients purchased and diet quality in a large sample of 225 ethnically and economically diverse adults...
- RCT of the Naturopathic Anti-inflammatory DietPatricia Elmer; Fiscal Year: 2007..The "anti-inflammatory"(AI) diet is frequently used and recommended to treat a variety of conditions classified by naturopathic physicians as "..
- Intestinal Microbiota, Diet and Risk of Colorectal AdenomasRobert S Sandler; Fiscal Year: 2010..Potential mechanisms for the link between gut microbiota and CRC is through diet and inflammation...
- Intestinal Microbiota, Diet and Risk of Colorectal AdenomasTemitope Keku; Fiscal Year: 2009..Potential mechanisms for the link between gut microbiota and CRC is through diet and inflammation...
