Summary: Regular course of eating and drinking adopted by a person or animal. This does not include DIET THERAPY, a specific diet prescribed in the treatment of a disease.

Top Publications

  1. pmc Linking long-term dietary patterns with gut microbial enterotypes
    Gary D Wu
    Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 334:105-8. 2011
  2. pmc Diet rapidly and reproducibly alters the human gut microbiome
    Lawrence A David
    1 FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA 2 Society of Fellows, Harvard University, Cambridge, Massachusetts 02138, USA 3 Molecular Genetics and Microbiology and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 505:559-63. 2014
  3. ncbi Microbial ecology: human gut microbes associated with obesity
    Ruth E Ley
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 444:1022-3. 2006
  4. pmc Globalization of diabetes: the role of diet, lifestyle, and genes
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 34:1249-57. 2011
  5. doi Gut microbiota composition correlates with diet and health in the elderly
    Marcus J Claesson
    Department of Microbiology, University College Cork, Ireland
    Nature 488:178-84. 2012
  6. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
  7. ncbi Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
  8. pmc Changes in diet and lifestyle and long-term weight gain in women and men
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:2392-404. 2011
  9. doi A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease
    Andrew Mente
    Population Health Research Institute, Hamilton General Hospital, 4 East Room 441, 237 Barton St E, Hamilton, ON L8L 2X2, Canada
    Arch Intern Med 169:659-69. 2009
  10. pmc Global nutrition transition and the pandemic of obesity in developing countries
    Barry M Popkin
    Department of Nutrition and Carolina Population Center, University of North Carolina at Chapel Hill, North Carolina 27516, USA
    Nutr Rev 70:3-21. 2012

Detail Information

Publications325 found, 100 shown here

  1. pmc Linking long-term dietary patterns with gut microbial enterotypes
    Gary D Wu
    Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 334:105-8. 2011
    b>Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals...
  2. pmc Diet rapidly and reproducibly alters the human gut microbiome
    Lawrence A David
    1 FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA 2 Society of Fellows, Harvard University, Cambridge, Massachusetts 02138, USA 3 Molecular Genetics and Microbiology and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 505:559-63. 2014
    ..The animal-based diet increased the abundance of bile-tolerant microorganisms (Alistipes, Bilophila and Bacteroides) and decreased the ..
  3. ncbi Microbial ecology: human gut microbes associated with obesity
    Ruth E Ley
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 444:1022-3. 2006 comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet. Our findings indicate that obesity has a microbial component, which might have potential therapeutic implications.
  4. pmc Globalization of diabetes: the role of diet, lifestyle, and genes
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 34:1249-57. 2011
    ..Nonetheless, interactions between Westernized diet and lifestyle and genetic background may accelerate the growth of diabetes in the context of rapid nutrition ..
  5. doi Gut microbiota composition correlates with diet and health in the elderly
    Marcus J Claesson
    Department of Microbiology, University College Cork, Ireland
    Nature 488:178-84. 2012
    ..However, clustering of subjects by diet separated them by the same residence location and microbiota groupings...
  6. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  7. ncbi Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    Improving diet and lifestyle is a critical component of the American Heart Association's strategy for cardiovascular disease risk reduction in the general population. This document presents recommendations designed to meet this objective...
  8. pmc Changes in diet and lifestyle and long-term weight gain in women and men
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:2392-404. 2011
    ..Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain...
  9. doi A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease
    Andrew Mente
    Population Health Research Institute, Hamilton General Hospital, 4 East Room 441, 237 Barton St E, Hamilton, ON L8L 2X2, Canada
    Arch Intern Med 169:659-69. 2009
    ..Although a wealth of literature links dietary factors and coronary heart disease (CHD), the strength of the evidence supporting valid associations has not been evaluated systematically in a single investigation...
  10. pmc Global nutrition transition and the pandemic of obesity in developing countries
    Barry M Popkin
    Department of Nutrition and Carolina Population Center, University of North Carolina at Chapel Hill, North Carolina 27516, USA
    Nutr Rev 70:3-21. 2012
    ..Concurrent rapid shifts in diet and activity are well documented as well...
  11. ncbi Obesity in children and young people: a crisis in public health
    T Lobstein
    IASO International Obesity TaskForce, 231 North Gower Street, London NW1 2NS, UK
    Obes Rev 5:4-104. 2004
  12. pmc Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University, St Louis, MO 63108, USA
    Cell Host Microbe 3:213-23. 2008
    We have investigated the interrelationship between diet, gut microbial ecology, and energy balance using a mouse model of obesity produced by consumption of a prototypic Western diet...
  13. doi The genomic signature of dog domestication reveals adaptation to a starch-rich diet
    Erik Axelsson
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden
    Nature 495:360-4. 2013
    ..Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication ..
  14. pmc Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    Fredrik Backhed
    Center for Genome Sciences and Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 104:979-84. 2007
    ..GF) animals are protected against the obesity that develops after consuming a Western-style, high-fat, sugar-rich diet. Their persistently lean phenotype is associated with increased skeletal muscle and liver levels of phosphorylated ..
  15. pmc Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans
    Brian D Muegge
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 332:970-4. 2011
    ..of bacterial 16S ribosomal RNA genes to gain an understanding of how microbial communities adapt to extremes of diet. We sampled fecal DNA from 33 mammalian species and 18 humans who kept detailed diet records, and we found that the ..
  16. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
    ..We studied the association between the local food environment and residents' report of recommended dietary intake...
  17. pmc Human nutrition, the gut microbiome and the immune system
    Andrew L Kau
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 474:327-36. 2011
    ..Understanding how our diet and nutritional status influence the composition and dynamic operations of our gut microbial communities, and the ..
  18. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
    ..Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics...
  19. pmc Both comprehensive and brief self-administered diet history questionnaires satisfactorily rank nutrient intakes in Japanese adults
    Satomi Kobayashi
    Department of Social and Preventive Epidemiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Epidemiol 22:151-9. 2012
    A comprehensive self-administered diet history questionnaire (DHQ: 150-item semi-quantitative questionnaire) and a brief self-administered DHQ (BDHQ: 58-item fixed-portion-type questionnaire) were developed for assessing Japanese diets...
  20. ncbi Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Diabetes 56:16-23. 2007
    ..We hypothesized that ATMs recruited to adipose tissue during a high-fat diet have unique inflammatory properties compared with resident tissue ATMs...
  21. pmc Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century
    Tanya L Blasbalg
    Section on Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 93:950-62. 2011
    ..The consumption of omega-3 (n-3) and omega-6 (n-6) essential fatty acids in Western diets is thought to have changed markedly during the 20th century...
  22. ncbi Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  23. ncbi Environmental contributions to the obesity epidemic
    J O Hill
    Colorado Clinical Nutrition Research Unit, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 280:1371-4. 1998
    ..Control of portion size, consumption of a diet low in fat and energy density, and regular physical activity are behaviors that protect against obesity, but it is ..
  24. pmc Dominant and diet-responsive groups of bacteria within the human colonic microbiota
    Alan W Walker
    Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, UK
    ISME J 5:220-30. 2011
    ..Volunteers were provided successively with a control diet, diets high in resistant starch (RS) or non-starch polysaccharides (NSPs) and a reduced carbohydrate weight loss (..
  25. ncbi Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    ..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP...
  26. ncbi Poverty and obesity: the role of energy density and energy costs
    Adam Drewnowski
    Center for Public Health Nutrition, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Am J Clin Nutr 79:6-16. 2004
    ..This review focuses on the relation between obesity and diet quality, dietary energy density, and energy costs. Evidence is provided to support the following points...
  27. pmc Effects of diet and development on the Drosophila lipidome
    Maria Carvalho
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Mol Syst Biol 8:600. 2012
    ..This study provides a comprehensive, quantitative and expandable resource for further pharmacological and genetic studies of metabolic disorders and molecular mechanisms underlying dietary response...
  28. doi Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
    Sheau Fang Ng
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, New South Wales, Sydney 2052, Australia
    Nature 467:963-6. 2010
    ..Although the detrimental impacts of diet-induced maternal obesity on adiposity and metabolism in offspring are well established, the extent of any ..
  29. pmc Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    Charlotte Bonnard
    INSERM, U870, IFR62, Oullins, France
    J Clin Invest 118:789-800. 2008
    ..during the development of insulin resistance and progression to diabetes in mice fed a high-fat, high-sucrose diet. Although 1 month of high-fat, high-sucrose diet feeding was sufficient to induce glucose intolerance, mice showed ..
  30. pmc A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
    Laura Palanker Musselman
    Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dis Model Mech 4:842-9. 2011
    ..Larvae reared on a high-sugar diet were hyperglycemic, insulin resistant and accumulated fat--hallmarks of T2D--compared with those reared on control ..
  31. pmc Projected effect of dietary salt reductions on future cardiovascular disease
    Kirsten Bibbins-Domingo
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    N Engl J Med 362:590-9. 2010
    The U.S. diet is high in salt, with the majority coming from processed foods. Reducing dietary salt is a potentially important target for the improvement of public health.
  32. ncbi Inflammation: the link between insulin resistance, obesity and diabetes
    Paresh Dandona
    Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo and Kaleida Health, 3 Gates Circle, Buffalo, NY 14209, USA
    Trends Immunol 25:4-7. 2004
    ..This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation...
  33. pmc The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors
    Goodarz Danaei
    Harvard School of Public Health, Boston, MA, USA
    PLoS Med 6:e1000058. 2009
  34. pmc High-fat diet determines the composition of the murine gut microbiome independently of obesity
    Marie A Hildebrandt
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 137:1716-24.e1-2. 2009
    The composition of the gut microbiome is affected by host phenotype, genotype, immune function, and diet. Here, we used the phenotype of RELMbeta knockout (KO) mice to assess the influence of these factors.
  35. pmc Fast food restaurants and food stores: longitudinal associations with diet in young to middle-aged adults: the CARDIA study
    Janne Boone-Heinonen
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516 3997, USA
    Arch Intern Med 171:1162-70. 2011
  36. ncbi Interactions and competition within the microbial community of the human colon: links between diet and health
    Harry J Flint
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB219SB, UK
    Environ Microbiol 9:1101-11. 2007
    ..of the human intestinal tract play an important role in health, in particular by mediating many of the effects of diet upon gut health...
  37. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  38. ncbi Does social class predict diet quality?
    Nicole Darmon
    INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, France
    Am J Clin Nutr 87:1107-17. 2008
    A large body of epidemiologic data show that diet quality follows a socioeconomic gradient...
  39. doi Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study
    Pamela L Lutsey
    Division of Epidemiology and Community Health, University of Minnesota, School of Public Health, Minneapolis, USA
    Circulation 117:754-61. 2008
    The role of diet in the origin of metabolic syndrome (MetSyn) is not well understood; thus, we sought to evaluate the relationship between incident MetSyn and dietary intake using prospective data from 9514 participants (age, 45 to 64 ..
  40. pmc Predicting a human gut microbiota's response to diet in gnotobiotic mice
    Jeremiah J Faith
    Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 333:101-4. 2011
    ..gene expression were measured in response to randomized perturbations of four defined ingredients in the host diet. From the responses, we developed a statistical model that predicted over 60% of the variation in species abundance ..
  41. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
    ..In the present study, the animals were fed either chow or a high-fat, Western-type diet and examined at ages ranging from 6 to 40 weeks...
  42. ncbi Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study
    Mark A Pereira
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2081-9. 2002
    ..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome ..
  43. pmc Differences in weight status and energy-balance related behaviors among schoolchildren across Europe: the ENERGY-project
    Johannes Brug
    Department of Epidemiology and Biostatistics and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e34742. 2012
    ..Current data on the prevalence of overweight and energy-balance behaviors among European children is necessary to inform overweight prevention interventions...
  44. doi Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice
    Masuko Kobori
    National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Mol Nutr Food Res 55:530-40. 2011
    To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression.
  45. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  46. ncbi Supermarkets, other food stores, and obesity: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Prev Med 30:333-9. 2006
    ..The purpose of this study was to examine whether characteristics of the local food environment are associated with the prevalence of cardiovascular disease risk factors...
  47. ncbi Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 8:731-7. 2002
    ..The KO mice exhibited severe diet-induced insulin resistance with reduced insulin-receptor substrate 1 (IRS-1)-associated phosphatidylinositol 3 ..
  48. doi Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models
    E F Murphy
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Gut 59:1635-42. 2010
    ..However, a causal relationship is unproven and contributory variables include diet, genetics and age...
  49. doi Systematic review of school-based interventions that focus on changing dietary intake and physical activity levels to prevent childhood obesity: an update to the obesity guidance produced by the National Institute for Health and Clinical Excellence
    T Brown
    School of Health and Social Care, University of Teesside, Middlesbrough, UK
    Obes Rev 10:110-41. 2009
    ..One of three diet studies, five of 15 physical activity studies and nine of 20 combined diet and physical activity studies ..
  50. ncbi Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases
    Barry M Popkin
    University of North Carolina, Chapel Hill, NC, USA
    Am J Clin Nutr 84:289-98. 2006
    ..Dietary changes appear to be shifting universally toward a diet dominated by higher intakes of animal and partially hydrogenated fats and lower intakes of fiber...
  51. pmc Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    Richard C Grandison
    Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
    Nature 462:1061-4. 2009
    ..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet.
  52. doi A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine
    Daniëlle Haenen
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Nutr 143:274-83. 2013
    ..The aim of this study was to investigate the effects of a diet high in RS on luminal microbiota composition, luminal SCFA concentrations, and the expression of host genes ..
  53. ncbi Identifying risk for obesity in early childhood
    Philip R Nader
    Division of Community Pediatrics, University of California, San Diego, California, USA
    Pediatrics 118:e594-601. 2006
    ..Our aim with this study was to assist clinicians by estimating the predictive value of earlier levels of BMI status on later risk of overweight and obesity during the middle childhood and early adolescent years...
  54. pmc Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, MUH N810, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    JAMA 304:1795-802. 2010
  55. doi Genetic diversity and diet specificity of ruminal Prevotella revealed by 16S rRNA gene-based analysis
    Aschalew Z Bekele
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    FEMS Microbiol Lett 305:49-57. 2010
    16S rRNA gene-based analysis of rumen Prevotella was carried out to estimate the diversity and diet specificity of bacteria belonging to this genus...
  56. pmc Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice
    Yan Y Lam
    Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, Australia
    PLoS ONE 7:e34233. 2012
    We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (HFD)...
  57. pmc A Drosophila model of high sugar diet-induced cardiomyopathy
    Jianbo Na
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Genet 9:e1003175. 2013
    ..Here we combine diet, genetics, and physiology to establish an adult Drosophila melanogaster model of chronic high sugar-induced heart ..
  58. pmc Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
    Ionel Sandovici
    Metabolic Research Laboratories, Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, United Kingdom
    Proc Natl Acad Sci U S A 108:5449-54. 2011
    ..One such factor that is known to play an important role in determining long-term metabolic health is diet during critical periods of development...
  59. pmc The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet
    Karen Lock
    European Centre on Health of Societies in Transition, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
    Bull World Health Organ 83:100-8. 2005
  60. ncbi The continuing epidemics of obesity and diabetes in the United States
    A H Mokdad
    Data Management Division, National Immunization Program, Centers for Disease Control and Prevention, MS E62, 1600 Clifton Rd, NE, Atlanta, GA 30333, USA
    JAMA 286:1195-200. 2001
    ..Recent reports show that obesity and diabetes have increased in the United States in the past decade...
  61. pmc Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    David E Harrison
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nature 460:392-5. 2009
    ..These findings have implications for further development of interventions targeting mTOR for the treatment and prevention of age-related diseases...
  62. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
    ..Modifiable behavioral risk factors are leading causes of mortality in the United States. Quantifying these will provide insight into the effects of recent trends and the implications of missed prevention opportunities...
  63. ncbi Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study
    M De Lorgeril
    Explorations Fonctionnelles Cardiorespiratoires et Métaboliques, CHU de Saint Etienne, France
    Circulation 99:779-85. 1999
    The Lyon Diet Heart Study is a randomized secondary prevention trial aimed at testing whether a Mediterranean-type diet may reduce the rate of recurrence after a first myocardial infarction...
  64. pmc α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis
    An Pan
    Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 96:1262-73. 2012
    ..Prior studies of α-linolenic acid (ALA), a plant-derived omega-3 (n-3) fatty acid, and cardiovascular disease (CVD) risk have generated inconsistent results...
  65. pmc Dietary pattern and depressive symptoms in middle age
    Tasnime N Akbaraly
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Br J Psychiatry 195:408-13. 2009
    Studies of diet and depression have focused primarily on individual nutrients.
  66. doi Changing diet and physical activity to reduce gestational weight gain: a meta-analysis
    B Gardner
    Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK
    Obes Rev 12:e602-20. 2011
    ..Intervention developers have assumed that adopting a healthier diet and increasing physical activity in pregnancy can limit weight gain, but evaluations of such interventions have ..
  67. pmc Systematic review of clinical trials on dietary interventions to prevent excessive weight gain during pregnancy among normal weight, overweight and obese women
    Ida Tanentsapf
    Faculty of Health Sciences, Copenhagen University, Panum Instituttet, Copenhagen, Denmark
    BMC Pregnancy Childbirth 11:81. 2011
    ..The primary objective of this review was to evaluate the effect of dietary interventions for reducing GWG. The secondary objective was to examine the impact of these interventions on different child and maternal health outcomes...
  68. doi The role of diet in the prevention of type 2 diabetes
    J Salas-Salvado
    Human Nutrition Unit, Hospital Universitari Sant Joan de Reus, Biochemistry and Biotechnology Department, IISPV, Universitat Rovira i Virgili, Reus, Spain
    Nutr Metab Cardiovasc Dis 21:B32-48. 2011
    ..Landmark clinical trials of lifestyle changes in subjects with prediabetes have shown that diet and exercise leading to weight loss consistently reduce the incidence of diabetes...
  69. doi DNA barcoding for ecologists
    Alice Valentini
    Laboratoire d Ecologie Alpine, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
    Trends Ecol Evol 24:110-7. 2009
    ..Even DNA-based diet composition can be estimated using fecal samples...
  70. pmc Test-retest reliability and construct validity of the ENERGY-child questionnaire on energy balance-related behaviours and their potential determinants: the ENERGY-project
    Amika S Singh
    VU University Medical Center, EMGO Institute for Health and Care Research, Dpt, of Public and Occupational Health, Amsterdam, The Netherlands
    Int J Behav Nutr Phys Act 8:136. 2011
    ..Therefore, reliable and valid tools to measure these variables in large-scale population research are needed...
  71. doi Can gestational weight gain be modified by increasing physical activity and diet counseling? A meta-analysis of interventional trials
    Ina Streuling
    Division of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Clin Nutr 92:678-87. 2010
    ..It is therefore of interest whether GWG can be modified by an intervention combining dietary counseling and physical activity...
  72. ncbi Dietary patterns of adolescents and risk of obesity and hypertension
    Sarah A McNaughton
    Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 3125 Melbourne, Australia
    J Nutr 138:364-70. 2008
    ..This study suggests that specific dietary patterns are already evident in adolescence and a dietary pattern rich in fruit, salad, cereals, and fish pattern may be associated with diastolic blood pressure in older adolescents...
  73. ncbi Empirically derived eating patterns using factor or cluster analysis: a review
    P K Newby
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Rev 62:177-203. 2004
    ..Although the research considered herein has created a meaningful body of literature, refining both the factor and cluster analysis methods will help to further establish eating patterns as a sound dietary assessment method...
  74. ncbi Flavonoid intake and risk of chronic diseases
    Paul Knekt
    National Public Health Institute, Helsinki, Finland
    Am J Clin Nutr 76:560-8. 2002
    ..Flavonoids are effective antioxidants and may protect against several chronic diseases...
  75. ncbi Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Diabetes 53:931-8. 2004
    ..These data provide the first in vivo evidence that adipose 11 beta-HSD-1 deficiency beneficially alters adipose tissue distribution and function, complementing the reported effects of hepatic 11 beta-HSD-1 deficiency or inhibition...
  76. pmc Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis
    Patrice Carter
    Diabetes Research, Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW
    BMJ 341:c4229. 2010
    ..To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes...
  77. ncbi Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis
    D S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Lancet 357:505-8. 2001
    ..The rising prevalence of obesity in children has been linked in part to the consumption of sugar-sweetened drinks. Our aim was to examine this relation...
  78. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  79. ncbi Food store types, availability, and cost of foods in a rural environment
    Angela D Liese
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    J Am Diet Assoc 107:1916-23. 2007
    ..To characterize the built nutritional environment in terms of types and number of food stores, availability, and cost of selected food items in a rural area...
  80. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
    ..The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe...
  81. pmc The local food environment and diet: a systematic review
    Caitlin E Caspi
    Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02114, USA
    Health Place 18:1172-87. 2012
    ..the problem of obesogenic environments, there has not been a comprehensive review evaluating the food environment-diet relationship...
  82. pmc Associations of the local food environment with diet quality--a comparison of assessments based on surveys and geographic information systems: the multi-ethnic study of atherosclerosis
    Latetia V Moore
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48103, USA
    Am J Epidemiol 167:917-24. 2008
    There is growing interest in understanding how food environments affect diet, but characterizing the food environment is challenging...
  83. ncbi Two neurons mediate diet-restriction-induced longevity in C. elegans
    Nicholas A Bishop
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 447:545-9. 2007
    ..However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated...
  84. doi Neighborhood environments: disparities in access to healthy foods in the U.S
    Nicole I Larson
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Am J Prev Med 36:74-81. 2009
    ..S. This article reviews research relating to the presence, nature, and implications of neighborhood differences in access to food...
  85. ncbi Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    Mitsuhiro Yokoyama
    Kobe University, Kobe, Japan
    Lancet 369:1090-8. 2007
    ..We aimed to test the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish...
  86. pmc Primary prevention of gestational diabetes mellitus and large-for-gestational-age newborns by lifestyle counseling: a cluster-randomized controlled trial
    Riitta Luoto
    UKK Institute for Health Promotion Research, Tampere, Finland
    PLoS Med 8:e1001036. 2011
    ..Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM...
  87. ncbi Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance
    Marjorie L McCullough
    American Cancer Society, Atlanta, GA 30329, USA
    Am J Clin Nutr 76:1261-71. 2002
    ..Research suggests that greater reductions in risk are possible with more specific guidance...
  88. doi Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease
    Anna Alisi
    Unit of Metabolic and Autoimmune Liver Diseases, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Lab Invest 91:283-93. 2011
    ..To this aim, Sprague-Dawley rats were fed ad libitum for 3 months with different diets: standard diet (SD), diet enriched in fats and low in carbohydrates (HFD), SD with high fructose (SD-HF) and diet with high levels ..
  89. ncbi Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    Gizem Rizki
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    J Lipid Res 47:2280-90. 2006
    ..MCD feeding also induces hepatic steatosis, by an independent mechanism. Viewed together, these two disparate consequences of MCD feeding (weight loss and hepatic steatosis) give the appearance of an unusual form of lipodystrophy...
  90. pmc Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:8924-30. 2010
    ..This provides genome-wide evidence for selection due to changes in ecoregion, diet, and subsistence...
  91. doi Salt intakes around the world: implications for public health
    Ian J Brown
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, UK
    Int J Epidemiol 38:791-813. 2009
    ..Comprehensive, contemporaneous sodium intake data from around the world are needed to inform national/international public health initiatives to reduce sodium consumption...
  92. ncbi Origins and evolution of the Western diet: health implications for the 21st century
    Loren Cordain
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Am J Clin Nutr 81:341-54. 2005
    There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry approximately 10000 y ago occurred too recently on ..
  93. ncbi The Malmö Diet and Cancer Study: representativity, cancer incidence and mortality in participants and non-participants
    J Manjer
    Department of Community Medicine, Lund University, , Sweden
    Eur J Cancer Prev 10:489-99. 2001
    ..bias in population-based cohort studies, participants (n = 28098) and non-participants (n = 40807) in the Malmö Diet and Cancer Study (MDCS) were compared with regard to cancer incidence and mortality...
  94. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005
    ..CB(1) (-/-) mice are resistant to diet-induced obesity even though their caloric intake is similar to that of wild-type mice, suggesting that ..
  95. pmc MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    Andre Kleinridders
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD and Center of Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 10:249-59. 2009
    ..To determine the functional significance of TLR signaling in the CNS in the development of leptin resistance and diet-induced obesity in vivo, we have characterized mice deficient for the TLR adaptor molecule MyD88 in the CNS (MyD88(..
  96. ncbi Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Arch Intern Med 167:956-65. 2007
    ..We examined associations between fiber and magnesium intake and risk of type 2 diabetes and summarized existing prospective studies by meta-analysis...
  97. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..We investigated the effects of maternal diet-induced obesity in mice on offspring metabolic and cardiovascular function...
  98. doi Diet, gut microbiota and immune responses
    Kendle M Maslowski
    Garvan Institute of Medical Research, and the Cooperative Research Centre for Asthma and Airways, Sydney, Australia
    Nat Immunol 12:5-9. 2011
    The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.
  99. ncbi Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization
    S Yusuf
    Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada
    Circulation 104:2746-53. 2001
    ..Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention...
  100. pmc Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity
    Do Young Park
    Korea Yakult Co, Ltd, Yongin, Gyeonggi, Republic of Korea
    PLoS ONE 8:e59470. 2013
    To investigate the functional effects of probiotic treatment on the gut microbiota, as well as liver and adipose gene expression in diet-induced obese mice.
  101. ncbi Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    Richard A Miller
    Department of Pathology, Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, MI 48109 0940, USA
    Aging Cell 4:119-25. 2005
    A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats...

Research Grants75

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..OTC) activity, the rate limiting step in ammonia metabolism, is a fair model, however the animals tolerate a diet containing normal amounts of protein, while severely affected human patients require severe protein restriction to ..
  2. Xenoestrogen regulation of Leydig cells
    ..Also, results will promote informed use of soy isoflavones in the diet, especially in neonates, in which the developing reproductive tract is sensitive to changes in the hormonal milieu...
  3. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..Second, PDK knock out mice maintained on a high-fat, diabetogenic diet accumulate less fat in their livers, are less obese, and have lower blood glucose levels, better glucose tolerance, ..
    Charles Knott; Fiscal Year: 2010
    ..on pesticides used and other agricultural exposures, lifestyle factors, medical and family history of disease, and diet. We are also collecting buccal cell samples as a source of genomic DNA for GXE studies and studies of epigenetic ..
    Charles Lynch; Fiscal Year: 2010
    ..on pesticides used and other agricultural exposures, lifestyle factors, medical and family history of disease, and diet. We are also collecting buccal cell samples as a source of genomic DNA for GXE studies and studies of epigenetic ..
  6. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..The efficacy of curcumin administered in the diet alone or in combination with ionizing radiation on orthotopic tumor growth and tumor cell death will be measured...
  7. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..2. Evaluate the potential therapeutic effects of CST and its variants on insulin sensitivity and baroreflex sensitivity and heart rate variability in high fat diet-induced insulin resistant and in db/db diabetic mice.
  8. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..b>Diet-Induced Obesity (DIP)...
  9. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..The brain makes dopamine from tyrosine, an amino acid present in the normal diet. For many years the supply of tyrosine to the brain was thought to be so ample that it did not limit dopamine ..
  10. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..hepatic SAMe deficiency occurs in MAT1A knockout (KO) mice, which exhibit increased propensity to choline-deficient diet induced fatty liver, higher level of lipid peroxidation, spontaneous development of steatohepatitis and HCC...
  11. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..will enroll 140 patients (100 with CLD due to hepatitis C and 40 normal controls) and obtain medical, lifestyle and diet data, as well as blood and urine samples...
  12. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..insulin/Akt signaling due to decreased amount of active PTEN (reduced form) and were resistance to high fat diet-induced diabetes...
  13. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..such as folic acid, pyridoxin (vitamin B6), cobalamine (vitamin B12);(iii) excessive intake of methionine rich diet. Folic acid and vitamin B12 facilitates remethylation of Hcy to Met, whereas vitamin B6 supports transsulfuration ..
  14. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..mice treated with ANG II that produces a slow pressor response and/or a high fat (60%) and high sucrose (20%) diet. A cohort of animals will be treated with an AT1R blocker (olmesartan) at a dose of 0...
  15. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..shown to increase the synthesis and secretion of triglycerides following a high-saturated fat or high-carbohydrate diet. Global deletion of SCD1 in mice results in an increase in food intake accompanied by elevations in energy ..
  16. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..We will also collect information on health history, clinical characteristics, tobacco smoke exposure, diet and time-activity patterns...
  17. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..tests developed in my laboratory may be used as markers of benefit opens the possibility of teasing out the biochemical and molecular signals that underlie the effects of diet, so that drugs which mimic these effects might be developed.
    Maureen J Charron; Fiscal Year: 2010
    ..Consumption of a western style, high fat (HF) diet during pregnancy has also been linked to vascular dysfunction, dyslipidemia and hyperglycemia in adults...
  19. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..The rationale for this project is that recent studies have shown significant effects of diet on modulation of miRNAs using both in vitro and in vivo models. However, such studies are lacking in kidney cancer...
  20. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..dietary retinoid normally in liver and are phenotypically normal when maintained on a retinoid-sufficient diet. However Rbp-/- mice are unable to mobilize/redistribute retinol from the liver to the periphery...
  21. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..Extracellular volume expansion promoted by a high Na diet induces local increases in PG synthesis, specifically prostaglandin E2 (PGE2), which is measurable in urine and ..
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..disabling macrophage inflamma- tory pathways in knockout mice protects animals from obesity and high fat diet induced insulin resistance, lead- ing to the idea that the tissue macrophage can be an orchestrating or initiating ..
    Lisa M Salati; Fiscal Year: 2012
    The amount and type of fat in the diet has been the subject of public health recommendations to prevent obesity, diabetes and atherosclerosis...
  24. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..vasodilatation and inhibit atherosclerosis in chimeric Ldlr-/-/MPO-/- and Ldlr-/- Tg-h-MPO+/+ mice fed western diet. Endothelium-dependent vasodilatation will be determined by videomicroscopy...
  25. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..deaths per year (3), and these numbers are destined to increase because of worldwide adoption of a Western-type diet (4)...
  26. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013
    ..recapitulated by pharmacologic inhibitors of Notch action, which were able to markedly improve glucose tolerance in diet- induced and genetic models of obesity. Dr...
  27. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..are highly regulated by nutritional status to maintain glucose and lipid homeostasis, and to protect against diet-induced hepatic steatosis, obesity and insulin resistance...
  28. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..will be studied before and after perturbations that alter insulin sensitivity including short-term very low calorie diet, after stabilization following 10% weight loss, and insulin-sensitizing thiazolidinedione treatment...
  29. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Women were randomized to reduced calorie weight loss "diet-only" that achieved a mean 9...
  30. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..While the linkage between PUFA metabolism and diabetic complications in humans is unclear, recent studies with diet-induced obese-diabetic mice have established a link between PUFA synthesis and diabetic complications...
  31. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..and workshops, proposal review panels and submission, and community health forums;2) research topics - to include diet, smoking cessation, hepatitis B, occupational exposure reduction, comparative- and cost-effectiveness of mobile ..
  32. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..g. toxicant exposures) and lifestyle choices (e.g. diet)...
  33. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..with the outcome of both interventions and can contribute to personalized care for hypertension by predicting patients most likely to effectively control their blood pressure by adopting salt-reducing diet and taking thiazide diuretics.
  34. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    ..Histological examination of livers from mice fed a TMHF diet for 9 weeks showed no signs of inflammation or necrosis...
  35. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..found that 2-week daily dosing of T1AM with doses approaching the 5g/kg range lead to significant weight loss in diet-induced obese mice...
    Jarmo Virtamo; Fiscal Year: 2010
    ..b>Diet was captured through a 276 food item dietary questionnaire that was developed and validated for the trial...
  37. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..Preliminary results from IPGTT in heterozygote knockout mice on Western diet has demonstrated increased glucose stimulated insulin levels and reduced hepatic glycogen content...
  38. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011 estradiol, both plant extracts produced a reduction in body weight and abdominal fat in mice fed a high fat diet. However, unlike estradiol, both plants did not stimulate the proliferation of MCF-7 breast cancer cells, which is ..
  39. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    ..PUBLIC HEALTH RELEVANCE: The studies described in this research proposal indicate that diet-derived plant bioflavonids influence the activity of genes in the epidermal growth factor (EGF) Signaling and cell ..
  40. Transgenerational effects of endocrine disruptors: epigenetics and physiology
    Rebecca A Simmons; Fiscal Year: 2013
    ..Human exposure to BPA is ubiquitous at low levels and occurs primarily through the diet. Studies in our laboratory and other investigators have shown that exposure of rodents to BPA during pregnancy ..
  41. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..Recent studies indicated the association of commensal bacteria with diet induced obesity and type 2 diabetes...
  42. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ..6. When compared to an isonitrogenous, isocaloric low carbohydrate/high fat diet, a high carbohydrate/low fat diet over a 7 day period: a...
  43. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..Our preliminary data show that: (1) obesity with insulin resistance induced by high-fat (HF) diet rich in saturated FAs up-regulates CD11c on blood monocytes and AT macrophages;(2) CD11c contributes to monocyte ..
  44. A2b Adenosine Receptor Regulation of Metabolic Disease and Inflammation
    Anna Eisenstein; Fiscal Year: 2013
    ..Furthermore, administration of a high fat, high cholesterol diet (HFD) vastly upregulates the expression of the A2b adenosine receptor (A2bAR), and A2bAR KO mice subjected to HFD ..
  45. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    ..Recently we discovered that (i) GDNF transgenic mice when fed a high fat diet resist weight gain and development of hepatic steatosis, despite similar food intake and physical activity...
  46. A Rodent Model to Study Links Among Diet, Visceral Adipose and Cardiomyopathy
    MELINDA ANN FRYE; Fiscal Year: 2013
    ..Here, interactions of rat strain and diet will be studied to optimize rodent models of OC, paring echocardiographic measures of myocardial structure and ..
  47. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..One reason for this discrepancy may be the high soy diet (genistein) consumed by Asians...
  48. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..In Avy mice that have an intracisternal A particle (IAP) in their agouti gene, exposure to a maternal diet-enriched in genistein or methyl- donors results in methylation of the IAP site and a graded shift from yellow coat ..
  49. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2013
    ..These findings lead to the hypothesis that: fatty acids, either fro diet or from adipocyte lipolysis, stimulate resident macrophages resulting in fatty acid binding protein-dependent ..
  50. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..A western diet (WD), especially characterized by excess intake of high fat, high sucrose and carbohydrates, is a major factor in ..
  51. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..Expression of this enzyme in osteoblasts is increased by EtOH and blocked by NAC. The mouse liquid diet model will be utilized to determine the role of NOX4 and oxidative stress in EtOH-induced bone resorption in vivo ..
  52. Obesity: neural control of body weight and metabolism
    Barry E Levin; Fiscal Year: 2013
    ..We have selectively bred rats which rapidly develop diet-induced obesity (DIO) when the caloric density of their diets is increased...
  53. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010 to arsenic in drinking water develop overt vascular disease by 10 weeks of age without high lipid diet and that liver gene expression suggests a pro-inflammatory state...
  54. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..The proposed studies will be performed on Ossabaw swine fed a normal maintenance diet (7% kcal from fat) or an atherogenic diet (45% kcal from fat and 2% cholesterol) for 20 weeks...
  55. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..Obesity is a chronic disease of staggering proportions. Because weight loss through diet and exercise is difficult to attain and maintain, there is escalating interest in surgical weight loss procedures, ..
  56. Genetic &Functional Analyses of Hypertension Susceptibility Genes
    YEN PEI CHRISTY CHANG; Fiscal Year: 2013
    ..Non-genetic factors such as obesity, high fat/sodium diet, stress, and physical inactivity contribute to a steady increase in the prevalence of HTN despite remarkable ..
  57. Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides
    SAMUEL BRANDON STEPHENS; Fiscal Year: 2013
    ..The Newgard lab also emphasizes the use of rodent models (genetic, diet-induced, and chemically-induced) to study aspects of obesity, insulin resistance, and islet [unreadable]-cell ..
  58. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013
    ..from the insulin resistance, glucose intolerance, obesity and liver steatosis that result from consuming a high fat diet. At least part of the protection is mediated via the central nervous system as CaMKK2 functions in neurons of the ..
  59. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..on nutrition information and foods that are pertinent to this population, with a focus on modifying the South Asian diet for weight loss, portion control, and making healthy food choices...
  60. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..e. exercise, irregular homeostatis, anoxia/hypoxia, diet etc.) contribute to interferences that lower sensor accuracy...
  61. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
    ..The studies will define the mechanism of an extremely important interaction between genes, epigenetic events, and diet in cancer prevention. It is well known that there are variations in BER capacity among humans...
  62. The Role of Adipocyte-Induced Inflammation in Prostate Tumor Progression
    ..The Aim 3 is to assess direct effects of high fat diet on inflammation of the bone marrow and determine the consequences of the resulting pro-inflammatory state on tumor ..
  63. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..Current treatment strategies are directed at changing patient lifestyle/diet and decreasing cholesterol via pharmacological methods...
    David Eaton; Fiscal Year: 2003
    Numerous studies have demonstrated that biologically active, natural components of the diet may confer resistance to chemical carcinogens via induction and/or inhibition of biotransformation enzymes...
  65. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..The DASH diet, which is rich in fruits, vegetables, whole grains, and low fat dairy products significantly lowers blood pressure ..
  66. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This RC1 application, Effect of Perinatal Diet on Developmental Programming of the Skeleton, addresses broad Challenge Area (15) Translational Science, and specific Challenge Topic 15-AR-104 Bone and ..
  67. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ..of obesity in pregnancy in order to determine the mechanisms underlying fetal overgrowth in response to high fat diet and increased adiposity...
  68. Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
    Steven A Abrams; Fiscal Year: 2010
    ..The specific objectives are (1) To measure the bioavailability of iron and zinc from a representative Indian diet (2) To measure the change in bioavailability of iron and zinc achievable by feasible diversification of a ..
    DANIEL BESSESSEN; Fiscal Year: 2001
    ..The specific aims are: 1) to define the dose-response relationship between the amylose content of the diet and postprandial glycemic/insulinemic response; 2) to measure adipocyte cell size and number in response to a high ..
  70. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ..The results of epidemiology studies indicate that diet has a profound influence on breast cancer risk...
    Ross Simpson; Fiscal Year: 1993
    ..The Model emphasizes provider-directed diet treatment facilitating referral to a nutritionist and drug treatment as necessary...
  72. Economic Contextual Influences on Population Diet and Obesity
    Lisa Powell; Fiscal Year: 2010
    Poor diet and obesity have been linked to increased risks for a number of chronic diseases including cancer and cardiovascular diseases...
    Cheryl Rock; Fiscal Year: 1999
    ..Evidence from epidemiologic studies strongly supports a role for a diet emphasizing fruits and vegetables, which provides carotenoids among an array of nutrients and other possibly ..
    ERNST SCHAEFER; Fiscal Year: 2003
    ..for low density lipoprotein (LDL) lowering and CHD risk reduction, but there controversy about other aspects of the diet. We propose to examine the effects of three diets meeting National Cholesterol Education program Step 2 diet ..
  75. RCT of the Naturopathic Anti-inflammatory Diet
    Patricia Elmer; Fiscal Year: 2007
    ..The "anti-inflammatory"(AI) diet is frequently used and recommended to treat a variety of conditions classified by naturopathic physicians as "..