Genomes and Genes
bacterial typing techniques
Summary: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Publications294 found, 100 shown here
- Guidelines for the validation and application of typing methods for use in bacterial epidemiologyA van Belkum
Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
Clin Microbiol Infect 13:1-46. 2007..A strategic effort on the part of all workers in the field is thus mandatory to combat emerging infectious diseases, as is financial support from national and international granting bodies and health authorities...
- Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureusM C Enright
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, Oxford University, Oxford OX1 3FY
J Clin Microbiol 38:1008-15. 2000..MLST provides an unambiguous method for assigning MRSA and MSSA isolates to known clones or assigning them as novel clones via the Internet...
- eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing dataEdward J Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
J Bacteriol 186:1518-30. 2004..pneumoniae and Staphylococcus aureus MLST databases, and the more complicated clonal complexes observed for Campylobacter jejuni and Neisseria meningitidis...
- Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosisPhilip Supply
INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
J Clin Microbiol 44:4498-510. 2006..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
- Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regionsYoko Kondo
Department of Infection Control Science, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Antimicrob Agents Chemother 51:264-74. 2007..The SCCmec type assignments were identical to those made with a PCR system that uses numerous primer pairs to identify genes or gene alleles. Our system of six M-PCRs is thus a convenient and reliable method for typing SCCmec elements...
- Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysisHajo Grundmann
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
PLoS Med 7:e1000215. 2010..We aimed to map the geographic distribution of the dominant clones that cause invasive infections in Europe...
- An epidemic, toxin gene-variant strain of Clostridium difficileL Clifford McDonald
Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 353:2433-41. 2005..difficile with increased virulence, resistance, or both...
- Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologiesIñaki Comas
Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK
PLoS ONE 4:e7815. 2009..Our findings have implications for strain typing in other genetically monomorphic bacteria...
- Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolatesRekha Pai
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 44:124-31. 2006....
- Extended-spectrum beta-lactamases: a clinical updateDavid L Paterson
Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Clin Microbiol Rev 18:657-86. 2005..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
- Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganismsM C Maiden
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 95:3140-5. 1998....
- Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriersHeiman F L Wertheim
Erasmus MC, University Medical Centre, Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
Lancet 364:703-5. 2004..006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous...
- Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseasesJill E Clarridge
Department of Laboratory Medicine, University of Washington, Seattle, USA
Clin Microbiol Rev 17:840-62, table of contents. 2004....
- How clonal is Staphylococcus aureus?Edward J Feil
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
J Bacteriol 185:3307-16. 2003....
- Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolatesCaroline Allix-Béguec
Genoscreen, 1, rue du Professeur Calmette, Lille 59019 Cedex, France
J Clin Microbiol 46:2692-9. 2008..The MIRU-VNTRplus database is a powerful tool for high-resolution clonal identification and has little equivalent in terms of functionalities among the bacterial genotyping databases available so far...
- Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern U.S. swine and swine workersTara C Smith
Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
PLoS ONE 4:e4258. 2009..However, no studies to date have investigated carriage of MRSA among swine and swine farmers in the United States (U.S.)...
- Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumanniiSergio G Bartual
Division de Microbiologia and Evolutionary Genomics Group, Campus de San Juan, Universidad Miguel Hernandez, San Juan de Alicante, Spain
J Clin Microbiol 43:4382-90. 2005..The MLST scheme provides a high level of resolution and an excellent tool for studying the population structure and long-term epidemiology of A. baumannii...
- Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolatesLaure Diancourt
Unité Biodiversité des Bactéries Pathogènes Emergentes U389 INSERM, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
J Clin Microbiol 43:4178-82. 2005..Forty distinct allelic profiles were identified. MLST data were validated against ribotyping and showed high (96%) discriminatory power. The MLST approach provides unambiguous data useful for the epidemiology of K. pneumoniae isolates...
- Multilocus sequence typing system for Campylobacter jejuniK E Dingle
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3FY, United Kingdom
J Clin Microbiol 39:14-23. 2001..Application of this approach to further isolate collections will enable an integrated global picture of C. jejuni epidemiology to be established and will permit more detailed studies of the population genetics of this organism...
- Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spreStephen Murchan
Laboratory of Hospital Infection, Central Public Health Laboratory, London NW9 5HT, United Kingdom
J Clin Microbiol 41:1574-85. 2003..This highlights the need for closer international collaboration to monitor the spread of current epidemic strains as well as the emergence of new ones...
- Infection and colonization with methicillin resistant Staphylococcus aureus ST398 versus other MRSA in an area with a high density of pig farmsM W H Wulf
PAMM Laboratory for Medical Microbiology, de Run 6250, Veldhoven, The Netherlands
Eur J Clin Microbiol Infect Dis 31:61-5. 2012..ST398 isolates were more often multi-resistant than isolates of other spa-types. The emergence of MRSA ST398 led to an increase in both MRSA carriers and MRSA infections...
- Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive unitsP Supply
Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F 59019 Lille cedex, France
J Clin Microbiol 39:3563-71. 2001..tuberculosis MIRU-VNTR genotypes via the Internet. This opens the way for global epidemiological surveillance of tuberculosis and should lead to novel insights into the evolutionary and population genetics of this major pathogen...
- Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strainsIda Parwati
Department of Clinical Pathology, Medical Faculty, Padjadjaran University, Dr Hasan Sadikin Hospital, Bandung, Indonesia
Lancet Infect Dis 10:103-11. 2010..More research is needed to further unravel the mechanisms underlying the emergence of M tuberculosis Beijing genotype strains, and examine the implications for future control strategies...
- Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP setIngrid Filliol
Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, MSB A920C, Newark, NJ 07103
J Bacteriol 188:759-72. 2006..tuberculosis...
- Ribosomal multilocus sequence typing: universal characterization of bacteria from domain to strainKeith A Jolley
Department of Zoology, University of Oxford, Oxford, UK
Microbiology 158:1005-15. 2012..This approach is applicable to the other domains of life, potentially providing a rational and universal approach to the classification of life that is based on one of its fundamental features, the translation mechanism...
- Report of the ad hoc committee for the re-evaluation of the species definition in bacteriologyErko Stackebrandt
DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany
Int J Syst Evol Microbiol 52:1043-7. 2002..The committee made various recommendations regarding the species definition in the light of developments in methodologies available to systematists...
- Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international studyM W H Wulf
Department of Medical Microbiology, Nijmegen University Centre for Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Microbiol Infect 14:29-34. 2008....
- Based Upon Repeat Pattern (BURP): an algorithm to characterize the long-term evolution of Staphylococcus aureus populations based on spa polymorphismsAlexander Mellmann
Institute for Hygiene, University Hospital Munster, Munster, Germany
BMC Microbiol 7:98. 2007..BURP was subsequently evaluated with a strain collection reflecting the breadth of diversity of S. aureus (JCM 2002; 40:4544)...
- Diversity of SCCmec elements in methicillin-resistant coagulase-negative staphylococci clinical isolatesZhiyong Zong
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
PLoS ONE 6:e20191. 2011..Characterization of SCCmec in MR-CoNS can generate useful information on the mobilization and evolution of this element...
- Evaluation of a two-step approach for large-scale, prospective genotyping of Mycobacterium tuberculosis isolates in the United StatesLauren S Cowan
Division of TB Elimination, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Clin Microbiol 43:688-95. 2005..IS6110 fingerprinting can then be used as a secondary typing method to type the clustered isolates when additional discrimination is needed...
- A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigensAndrew McDowell
Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
Microbiology 157:1990-2003. 2011..The MLST scheme and database described in this study should provide a valuable platform for future epidemiological and evolutionary studies of P. acnes...
- Hyper-recombination, diversity, and antibiotic resistance in pneumococcusWilliam Paul Hanage
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
Science 324:1454-7. 2009..This could have consequences for the reemergence of drug resistance after pneumococcal vaccination and also for our understanding of diversification and speciation in recombinogenic bacteria...
- Improved multilocus sequence typing scheme for Staphylococcus epidermidisJonathan C Thomas
Department of Infectious Disease Epidemiology, St Mary s Hospital Campus, Imperial College London, London W2 1PG, United Kingdom
J Clin Microbiol 45:616-9. 2007..This improved scheme gave 31 sequence types (STs) and 5 clonal complexes (CCs), whereas the other schemes delineate 16 to 24 STs and 1 to 3 CCs...
- The evolution of Staphylococcus aureusRuud H Deurenberg
Department of Medical Microbiology, University Hospital Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands
Infect Genet Evol 8:747-63. 2008..This review describes the latest observations about the structure of SCCmec, the techniques used to study the molecular epidemiology and evolution of S. aureus as well as some challenges that researchers face in the future...
- Evaluation of Brucella MLVA typing for human brucellosisSascha Al Dahouk
Bundeswehr Institute of Microbiology, Department of Bacteriology, Neuherbergstr 11, D 80937 Munich, Germany
J Microbiol Methods 69:137-45. 2007..MLVA can significantly contribute to epidemiological trace-back analysis of Brucella infections and may advance surveillance and control of human brucellosis...
- Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing dataE J Feil
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, United Kingdom
Genetics 154:1439-50. 2000..We also demonstrate how to estimate the average length of recombinational replacements from MLST data...
- High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiologyE Mazars
, , U447, Institut Pasteur de Lille, rue du Prof. Calmette, F-59019 Lille Cedex, France
Proc Natl Acad Sci U S A 98:1901-6. 2001..This typing method opens the way to the construction of digital global databases for molecular epidemiology studies of M. tuberculosis...
- Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'Catarina Milheiriço
Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
J Antimicrob Chemother 60:42-8. 2007..To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR...
- A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive diseaseM C Enright
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
Microbiology 144:3049-60. 1998..A Web site for the molecular characterization of pneumococci by MLST is available (http ://mlst.zoo.ox.ac.uk)...
- Displaying the relatedness among isolates of bacterial species -- the eBURST approachBrian G Spratt
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital, Old Medical School Building, London W2 1PG, UK
FEMS Microbiol Lett 241:129-34. 2004..We discuss the advantages of this approach and describe its use to explore patterns of descent within clonal complexes identified using multilocus sequence typing...
- Coxiella burnetii in humans and ticks in rural SenegalOleg Mediannikov
URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
PLoS Negl Trop Dis 4:e654. 2010..Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts...
- Assessment of an optimized mycobacterial interspersed repetitive- unit-variable-number tandem-repeat typing system combined with spoligotyping for population-based molecular epidemiology studies of tuberculosisMara Cardoso Oelemann
INSERM, U629, Institut Pasteur de Lille, Lille, France
J Clin Microbiol 45:691-7. 2007..tuberculosis transmission...
- spa Typing of Staphylococcus aureus as a frontline tool in epidemiological typingB Strommenger
Robert Koch Institute, Wernigerode Branch, Burgstr 37, D 38855 Wernigerode, Germany
J Clin Microbiol 46:574-81. 2008..They should be selected by dependence on the clonal lineage indicated by spa typing and subsequent BURP analysis as well as on the basis of the particular question to be addressed...
- Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based methodEdgar Abadia
Institute of Genetics and Microbiology, UMR8621, IGEPE Team, UniverSud, CNRS Université Paris Sud 11, France
Infect Genet Evol 10:1066-74. 2010..It also allows evaluation of spoligotype-signature significance towards a more comprehensive understanding of the evolutionary mechanisms of the clustered regularly interspaced short palindromic repeat (CRISPR) locus in MTC...
- Multilocus sequence typing of Clostridium difficileDavid Griffiths
Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Clin Microbiol 48:770-8. 2010..difficile in total stool DNA extracts without isolate culture. The direct (nonculture) MLST approach may prove useful as a rapid genotyping method, potentially benefiting individual patients and informing hospital infection control...
- Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs on German farms and import of livestock-related MRSA into hospitalsR Kock
Institute of Hygiene, University Hospital Munster, Robert Koch Str 41, 48149, Munster, Germany
Eur J Clin Microbiol Infect Dis 28:1375-82. 2009..Our results indicate that livestock represents a relevant reservoir for the import of MRSA into regional German hospitals...
- Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprintsStefan Niemann
Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
PLoS ONE 4:e7407. 2009..According to the standard view, isolates exhibiting the same fingerprinting pattern are considered direct progeny of the same bacterial clone, and most likely reflect ongoing transmission or disease relapse within individual patients...
- Three-year population-based evaluation of standardized mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing of Mycobacterium tuberculosisCaroline Allix-Béguec
Molecular Mechanisms of Bacterial Pathogenesis, INSERM U629, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, F 59021 Lille cedex, France
J Clin Microbiol 46:1398-406. 2008..g., large sequence polymorphisms. Our results reinforce the proposal of standardized MIRU-VNTR typing as a new reference genotyping method for the epidemiological and phylogenetic screening of M. tuberculosis strains...
- Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: an international multicentre studyVincent Perreten
Institute of Veterinary Bacteriology, University of Berne, Berne, Switzerland
J Antimicrob Chemother 65:1145-54. 2010..The aim of this study was to determine the phenotypic and genotypic resistance profiles of methicillin-resistant Staphylococcus pseudintermedius (MRSP) and to examine the clonal distribution in Europe and North America...
- Host association of Campylobacter genotypes transcends geographic variationSamuel K Sheppard
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Appl Environ Microbiol 76:5269-77. 2010..These findings are consistent with local and international transmission of host-associated lineages among food animal species and provide a foundation for further improvements in genetic attribution...
- Are host genetics the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans?Raymond Ruimy
EA3964 Université Paris Diderot and Centre National de Référence, Résistance bactérienne dans les flores commensales, Hopital Bichat Claude Bernard, AP HP, Paris, France
J Infect Dis 202:924-34. 2010..Therefore, we concomitantly assessed the epidemiological, microbiological, and human-genetic carriage-related factors in a nearly closed population...
- Global emm type distribution of group A streptococci: systematic review and implications for vaccine developmentAndrew C Steer
Centre for International Child Health, University of Melbourne, Australia
Lancet Infect Dis 9:611-6. 2009....
- Trends in production of extended-spectrum beta-lactamases among Enterobacteriaceae of clinical interest: results of a nationwide survey in Belgian hospitalsH Rodriguez-Villalobos
Laboratoire de Microbiologie, Hopital Universitaire Erasme, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
J Antimicrob Chemother 66:37-47. 2011..to assess the frequency and diversity of extended-spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolates in Belgium...
- Direct identification of bacteria in positive blood culture bottles by matrix-assisted laser desorption ionisation time-of-flight mass spectrometryBernard La Scola
Pôle des Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille and URMITE UMR CNRS IRD 6236, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
PLoS ONE 4:e8041. 2009..In order to speed up the identification process, in the present work we attempted bacterial identification directly from blood culture bottles detected positive by the automate...
- Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognitionStefan Monecke
Institute for Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
FEMS Immunol Med Microbiol 53:237-51. 2008..Additionally, there are some isolated lineages, such as ST75, ST93, or ST152. These strains produce aberrant hybridization profiles, indicating that only a part of the gene pool of S. aureus has been investigated yet...
- Molecular epidemiologic typing systems of bacterial pathogens: current issues and perspectivesM J Struelens
Service de Microbiologie, Hopital Erasme, Bruxelles, Belgium
Mem Inst Oswaldo Cruz 93:581-5. 1998..Accurate epidemiological interpretation of data obtained with molecular typing systems still requires additional research on the evolution rate of polymorphic loci in bacterial pathogens...
- Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology networkL McGee
MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
J Clin Microbiol 39:2565-71. 2001..This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks...
- Pseudomonas aeruginosa population structure revisitedJean Paul Pirnay
Laboratory for Molecular and Cellular Technology, Burn Centre, Queen Astrid Military Hospital, Brussel, Belgium
PLoS ONE 4:e7740. 2009..aeruginosa "core lineage" and typically exhibited the exoS(+)/exoU(-) genotype and group B oprL and oprD alleles. This is to our knowledge the first report of an MST analysis conducted on a polyphasic data set...
- Development of a new PCR-ribotyping method for Clostridium difficile based on ribosomal RNA gene sequencingP Bidet
Laboratoire de Bacteriologie, Centre Hospitalo Universitaire Saint Antoine, Assistance Publique Hopitaux de Paris, France
FEMS Microbiol Lett 175:261-6. 1999..This typing method has evidenced major qualities such as easiness, rapidity and reproducibility. However, its discriminatory power has to be evaluated to validate its importance as a typing tool for C. difficile...
- DNA microarray-based genotyping of methicillin-resistant Staphylococcus aureus strains from Eastern SaxonyS Monecke
Institute for Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
Clin Microbiol Infect 14:534-45. 2008..Detection of such variants can sometimes allow epidemic strains to be resolved beyond spa types to a hospital-specific level, which is of significant value for epidemiological purposes...
- Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in TaipeiHorng Yunn Dou
Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan, Republic of China
BMC Infect Dis 8:170. 2008..Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture...
- Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosaBarry Curran
Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
J Clin Microbiol 42:5644-9. 2004..aeruginosa, the lack of a linkage between toxA type and serotype is not surprising and reveals the strength of the MLST approach for obtaining a better understanding of the epidemiology of P. aeruginosa...
- PCR-based quantitation and clonal diversity of the current prevalent invasive serogroup 6 pneumococcal serotype, 6C, in the United States in 1999 and 2006 to 2007Maria Da Gloria Carvalho
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 47:554-9. 2009..Fifteen 6C isolates shared one of four different MLST types with 6C-negative CS6As. MLST results suggest 6C strains arose from independent recombination events involving only serotype 6A and 6C parental strains...
- Tracing the source of campylobacteriosisDaniel J Wilson
Department of Maths and Statistics, Lancaster University, Lancaster, United Kingdom
PLoS Genet 4:e1000203. 2008..Our results imply that the primary transmission route is through the food chain, and suggest that incidence could be dramatically reduced by enhanced on-farm biosecurity or preventing food-borne transmission...
- spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariationLarry Koreen
Public Health Research Institute, International Center for Public Health, Graduate School of Biomedical Sciences and New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
J Clin Microbiol 42:792-9. 2004..This study showed that genetic analysis of the repeat region of protein A comprehensively characterizes both micro- and macrovariation in the primarily clonal population structure of S. aureus...
- Emergence of a community-associated methicillin-resistant Staphylococcus aureus strain with a unique resistance profile in Southwest NigeriaB Ghebremedhin
Otto von Guericke University Clinic, Medical Microbiology, Magdeburg, Germany
J Clin Microbiol 47:2975-80. 2009..Urban regions with populations of lower socioeconomic status and evidence of overcrowding appear to be at high risk for the emergence of this clone...
- Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat anGeorge Killgore
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 46:431-7. 2008..All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks...
- Bacterial strain typing in the genomic eraWenjun Li
Unité des Rickettsies et pathogènes émergents, CNRS UMR 6236, IRD 198, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
FEMS Microbiol Rev 33:892-916. 2009....
- Assignment of Staphylococcus isolates to groups by spa typing, SmaI macrorestriction analysis, and multilocus sequence typingB Strommenger
Wernigerode Branch, Robert Koch Institute, Burgstr 37, D 38855 Wernigerode, and Department of Periodontology, University Hospital Munster, Germany
J Clin Microbiol 44:2533-40. 2006..aureus epidemiology, especially because of ease of use and the advantages of unambiguous sequence analysis as well as reproducibility and exchange of typing data...
- Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typingWei Gang Qiu
Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:14150-5. 2004..Frequent recombination implies a potential for rapid adaptive evolution and a possible polygenic basis of B. burgdorferi pathogenicity...
- Phylogenetic and genomic diversity of human bacteremic Escherichia coli strainsFrançoise Jaureguy
INSERM UMR570, Faculte de Medecine, Universite Paris Descartes, Paris, France
BMC Genomics 9:560. 2008..A subset representative of the clonal diversity was subjected to comparative genomic hybridization (CGH) using 2,324 amplicons from the flexible gene pool of E. coli...
- Livestock associated methicillin-resistant Staphylococcus aureus (LaMRSA) isolated from lesions of pigs at necropsy in northwest Germany between 2004 and 2007D Meemken
Field Station for Epidemiology, University of Veterinary Medicine Hannover, Foundation, Bakum, Germany
Zoonoses Public Health 57:e143-8. 2010..We assume that MRSA in pigs may have occurred earlier than 2004 and might be not really 'emerging', but rather have been overlooked until recently. The potentially causative role of the MRSA in the lesions warrants further investigation...
- Molecular evidence of cholera outbreak caused by a toxigenic Vibrio cholerae O1 El tor variant strain in Kelantan, MalaysiaGeik Yong Ang
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia
J Clin Microbiol 48:3963-9. 2010..cholerae O1 El Tor variant has invaded Malaysia, highlighting the need for continuous monitoring to facilitate early interventions against any potential epidemic by this biotype...
- Evaluation of 24 locus MIRU-VNTR genotyping of Mycobacterium tuberculosis isolates in CanadaSara Christianson
National Microbiology Laboratory, 1015 Arlington Avenue, Winnipeg, Manitoba R3E 3R2, Canada
Tuberculosis (Edinb) 90:31-8. 2010..For long-term surveillance of MTBC within Canada, the use of 24 MIRU-VNTR loci will provide rapid, highly discriminatory molecular epidemiology information...
- Species identification of clinical isolates of Bacteroides by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometryE Nagy
Institute of Clinical Microbiology, University of Szeged, H 6701 Szeged, Hungary
Clin Microbiol Infect 15:796-802. 2009..The discriminating power and identification accuracy of MALDI-TOF MS proved to be superior to that of biochemical testing for Bacteroides thetaiotaomicron, Bacteroides ovatus and Bacteroides uniformis...
- Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccineR Sá-Leão
Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
Clin Microbiol Infect 15:1002-7. 2009..Rates of antibiotic resistance remained unchanged due to a balance between reduction in VT and an increase in antimicrobial-resistant NVT...
- Bacterial flora-typing with targeted, chip-based PyrosequencingAndreas Sundquist
Department of Computer Science, Stanford University, Stanford, CA 94305, USA
BMC Microbiol 7:108. 2007..In particular, classifying the microbial content of samples by sequencing the < 1,600 bp 16S rRNA gene will be affected by such limitations...
- Comparison of two multilocus variable-number tandem-repeat methods and pulsed-field gel electrophoresis for differentiating highly clonal methicillin-resistant Staphylococcus aureus isolatesA Holmes
Microbiology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
J Clin Microbiol 48:3600-7. 2010..However, due to its greater discriminatory power, MLVF would be the most suitable alternative to PFGE for hospital outbreak investigations...
- Staphylococcus aureus nasal carriage, virulence traits, antibiotic resistance mechanisms, and genetic lineages in healthy humans in Spain, with detection of CC398 and CC97 strainsCarmen Lozano
Area Bioquímica y Biología Molecular, Universidad de La Rioja, Madre de Dios 51, 26006 Logrono, Spain
Int J Med Microbiol 301:500-5. 2011..Interestingly, MSSA CC398 and CC97 isolates were detected. These clonal complexes are associated with food-producing animals...
- Molecular methods for Mycobacterium tuberculosis strain typing: a users guideE Kanduma
Clinical Laboratory, Kilimanjaro Christian Medical College, PO Box 3010, Moshi, Tanzania
J Appl Microbiol 94:781-91. 2003..If matches are found, then further confirmation of identity can be achieved using IS6110 RFLP or PGRS if the strains prove to have a low IS6110 copy number...
- Detection of Streptococcus pneumoniae strain cocolonization in the nasopharynxSilvio D Brugger
Institute for Infectious Diseases, University of Bern, Friedbuhlstrasse 51, CH 3010 Bern, Switzerland
J Clin Microbiol 47:1750-6. 2009..025). This new technique allows for the rapid and economical study of pneumococcal cocolonization in nasopharyngeal swabs. It will be valuable for the surveillance of S. pneumoniae epidemiology under vaccine selection pressure...
- Ecotypes of the Mycobacterium tuberculosis complexNoel H Smith
TB Research Group, Veterinary Laboratories Agency, VLA, Addlestone, Surrey KT15 3NB, UK
J Theor Biol 239:220-5. 2006..Finally, we discuss the application of the ecotype concept to this series of clades and suggest that the M. tuberculosis complex may best be described as a series of host-adapted ecotypes...
- Assigning Escherichia coli strains to phylogenetic groups: multi-locus sequence typing versus the PCR triplex methodDavid M Gordon
School of Botany and Zoology, Australian National University, Canberra ACT 0200, Australia
Environ Microbiol 10:2484-96. 2008..Strains failing to yield any PCR products using the Clermont method are seldom members of phylo-group A and strains with such a genotype should not be assigned to a phylo-group...
- Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence areaPhilip Supply
Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, Cedex, France
Mol Microbiol 47:529-38. 2003..This linkage disequilibrium was also evident when the MIRU-VNTR types were compared with the IS6110 restriction fragment length polymorphism types. These results support a predominant clonal evolution of M. tuberculosis...
- Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureusKunyan Zhang
Centre for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Calgary, Alberta, Canada T2L 2K8
J Clin Microbiol 43:5026-33. 2005..This novel assay offers a rapid, simple, and feasible method for SCCmec typing of MRSA, and may serve as a useful tool for clinicians and epidemiologists in their efforts to prevent and control infections caused by this organism...
- MLVA-16 typing of 295 marine mammal Brucella isolates from different animal and geographic origins identifies 7 major groups within Brucella ceti and Brucella pinnipedialisMarianne Maquart
INRA, UR1282, Infectiologie Animale et Sante Publique, IASP, Nouzilly, F 37380, France
BMC Microbiol 9:145. 2009..A previously published assay comprising 16 loci (MLVA-16) that has been shown to be highly relevant and efficient for typing and clustering Brucella strains from animal and human origin was used...
- Community-associated methicillin-resistant Staphylococcus aureus isolated in Finland in 2004 to 2006Mari Kanerva
National Institute for Health and Welfare, Department of Infectious Disease Epidemiology and Control, Helsinki, Finland
J Clin Microbiol 47:2655-7. 2009..9/100,000 population) and strain variation increased in comparison to years 1997 to 1999. There were 7 community-associated epidemic and 25 sporadic MRSA strain types. Half of these had Panton-Valentine leukocidin genes...
- Genetic determinants of virulence, antibiogram and altered biotype among the Vibrio cholerae O1 isolates from different cholera outbreaks in IndiaA K Goel
Biotechnology Division, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
Infect Genet Evol 10:815-9. 2010..In addition, in 2007, a new variant of O1 El Tor strain with further modifications in ctxB of classical biotype is discovered among the Indian isolates...
- First multi-locus sequence typing scheme for Arcobacter sppWilliam G Miller
Produce Safety and Microbiology Research Unit, Agricultural Research Service, US Department of Agriculture, Albany, CA 94710, USA
BMC Microbiol 9:196. 2009..Here, we describe the first Arcobacter multilocus sequence typing (MLST) method for A. butzleri, A. cryaerophilus, A. skirrowii, A. cibarius and A. thereius...
- SNP/RD typing of Mycobacterium tuberculosis Beijing strains reveals local and worldwide disseminated clonal complexesAnita C Schürch
Tuberculosis Reference Laboratory, National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control, CIb LIS, pb 22, Bilthoven, The Netherlands
PLoS ONE 6:e28365. 2011..The SNPs and RDs presented in this study will facilitate future molecular epidemiological and phylogenetic studies on Beijing strains...
- Comparison of genotypes and antibiotic resistance of Campylobacter jejuni isolated from humans and slaughtered chickens in SwitzerlandS Kittl
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
J Appl Microbiol 110:513-520. 2011..To get an overview of genotypes and antibiotic resistances in Swiss Campylobacter jejuni implicated in human gastroenteritis and to examine the association with isolates from chickens...
- Mutation rates of spoligotypes and variable numbers of tandem repeat loci in Mycobacterium tuberculosisJosephine F Reyes
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
Infect Genet Evol 10:1046-51. 2010..These findings confirm the high level of discrimination observed using multilocus VNTR typing, and suggest that caution should be taken not to underestimate the extent of recent transmission when using this marker...
- Sharing of Escherichia coli sequence type ST131 and other multidrug-resistant and Urovirulent E. coli strains among dogs and cats within a householdJames R Johnson
Infectious Diseases 111F, Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
J Clin Microbiol 47:3721-5. 2009..Of the four other colonizing strains identified, two were MDR and two colonized multiple hosts. The ST131 strain uniquely exhibited high resistance and virulence scores...
- Comparative evaluation of new typing schemes for urogenital Chlamydia trachomatis isolatesLarisa N Ikryannikova
Research Institute for Physical Chemical Medicine of Ministry of Public Health of the Russian Federation, Moscow, Russia
FEMS Immunol Med Microbiol 59:188-96. 2010..trachomatis population in Central Russia using MLST. We conclude that the MLST(7) scheme is the best possible choice for global epidemiological purposes, whereas MLST(5) is more appropriate for tracing local outbreaks...
- Rapid and high resolution genotyping of all Escherichia coli serotypes using 10 genomic repeat-containing lociInger Løbersli
Division of Infectious Diseases Control, Norwegian Institute of Public Health, Lovisenberggata 8, P O Box 4404 Nydalen, N 0403 Oslo, Norway
J Microbiol Methods 88:134-9. 2012..The GECM7 method was improved by adding three new repeat-loci to a total of ten (GECM10), and a considerable increase in resolution was observed (from 296 to 507 genotypes on the same set of strains)...
- Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, ChinaWei Wei Jiao
Public Central Laboratory, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
J Clin Microbiol 46:1045-9. 2008..tuberculosis isolates in Beijing, while secondary typing of clustered strains by IS6110-RFLP is still required...
- Biotyping of Vibrio cholerae O1: time to redefine the schemeAmit Raychoudhuri
Division of Microbiology, National Institute of Cholera and Enteric Diseases, Kolkata, India
Indian J Med Res 128:695-8. 2008..A revised biotyping scheme will play a significant role to understand the ecology, epidemiology and nature of infection of V. cholerae O1 strains in future...
- Genome-wide single nucleotide polymorphism typing method for identification of Bacillus anthracis species and strains among B. cereus group speciesMakoto Kuroda
Laboratory of Bacterial Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
J Clin Microbiol 48:2821-9. 2010..Subsequent whole-genome sequencing will reveal apparent strain-specific genetic markers for traceability of strains following an anthrax outbreak...
- Identification and characterization of methicillin-resistant coagulase-negative staphylococci from bovine mastitisAndrea T Fessler
Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Neustadt Mariensee, Germany
J Antimicrob Chemother 65:1576-82. 2010....
- New variants of Vibrio cholerae O1 biotype El Tor with attributes of the classical biotype from hospitalized patients with acute diarrhea in BangladeshG Balakrish Nair
Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka 1000, Bangladesh
J Clin Microbiol 40:3296-9. 2002..Furthermore, the existence of such novel strains may have implications for the development of a cholera vaccine...
- Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccinesGail L Rodgers
Scientific Affairs and Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA 19426, USA
Vaccine 27:3802-10. 2009....
- GOLD QUENCHED MOLECULAR BEACONSRichard Powell; Fiscal Year: 2003..abstract_text> ..
- Resistant E.coli in Humans and PoultryJames Johnson; Fiscal Year: 2005..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
- Intrabody Therapy in Drosophila for Huntington's DiseaseWILLIAM WOLFGANG; Fiscal Year: 2006..If successful this will provide validation of intrabodies as disease therapeutics and impetus to proceed to preclinical testing in vertebrate models of HD. ..
- Forensic Detection of Salmonella Resistance and SubtypeLee Harrison; Fiscal Year: 2005..enterica and 2) molecular methods for rapid outbreak detection among S. enterica serovars. ..
- New Pathogens for Childhood CariesAnne Tanner; Fiscal Year: 2008..As a result, it is expected that many of the negative consequences of this disease will be avoided, with attendant reductions in the costs of dental and related medical care. ..
- Fracture Characteristics of Dental MaterialsLuke Hanley; Fiscal Year: 2008..abstract_text> ..
- GEOGRAPHIC VARIABILITY IN EMERGENCY DEPARTMENT USE FOR PEDIATRIC ASTHMAJon Mark Hirshon; Fiscal Year: 2007..The research has potential nationwide applicability and could lead to innovative strategies to meet the Healthy People 2010 objective 24-3 focused on decreasing ED utilization for asthma. ..
- Diarrhea in Baltimore: Surveillance & Pathogen DetectionJon Mark Hirshon; Fiscal Year: 2006..Through this work, we expect to not only better define the causes of diarrheal illnesses in the Baltimore Metropolitan area, but to identify other pathogens that contribute to foodborne illnesses. ..
- Therapeutic vaccine against tuberculosisLee Riley; Fiscal Year: 2006..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
- ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSISLee Riley; Fiscal Year: 2001....
- Epidemiology of an uropathogenic E coli clonal groupLee Riley; Fiscal Year: 2003..coli can be spread by contaminated ingestible vehicles, and use the data generated from this project to design long-term studies to better characterize risk factors associated with CgA infection. ..
- MODULATION OF CELL SIGNALING BY PSEUDOMONAS EXOENZYME SJoan Olson; Fiscal Year: 2003....
- INITIAL LESION OF ADULT PERIODONTITISAnne Tanner; Fiscal Year: 2002....
- Pneumococcal conjugate vaccines and old adultsMOON NAHM; Fiscal Year: 2009..This study will enhance the knowledge of pneumococcal antibodies made by old adults and will help us determine if PCVs can be useful in pneumococcal vaccination of old adults, a major goal of our national health care policy. ..
- In vivo regulation of M. tuberculosis cell wall lipidsLee W Riley; Fiscal Year: 2010..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
- Novel Chemical Analyses of the Biofilm-Biomaterial InterfaceLuke Hanley; Fiscal Year: 2010..Specific Aim 2: Probe antibiotic resistance in S. epidermidis biofilms. Specific Aim 3: Probe RIP inhibition of S. epidermidis biofilm growth. Specific Aim 4: Probe chitosan inhibition of biofilm growth. ..
- SPECTROSCOPY OF BIOMEMBRANE MONOLAYERSRichard Dluhy; Fiscal Year: 2006..unreadable] [unreadable]..
- iNOS, COX-2, and Arginase in Murine Barrett's EsophagusKeith Wilson; Fiscal Year: 2003..We will study macroscopic and histologic evidence of esophagitis, BE and BAA, gene expression, apoptosis and proliferation in A. wild-type (WT) vs. COX-2-/- mice, B. W'I- vs. iNOS -/-mice, and C. WT vs. argll -/- mice. ..
- SPECTROSCOPY OF BIOMEMBRANE MONOLAYERSRichard Dluhy; Fiscal Year: 2002..abstract_text> ..
- Orgin of multidrug resistant uropathogenic E. coliLee Riley; Fiscal Year: 2008..This knowledge should lead to the implementation of improved control of drug-resistant infectious diseases. ..
- Detection of Pathogens in Avian Fecal PollutionSANDRA MCLELLAN; Fiscal Year: 2003..abstract_text> ..
- Identifying Autism Susceptibility Genes By High-Throughput Chip ResequencingMichael Zwick; Fiscal Year: 2009..Identifying the genetic basis of autism could enable more rapid diagnostic testing and provide insight into the root causes and eventually pave the way for better treatments of this increasingly common disorder. ..
- MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSISLee Riley; Fiscal Year: 2002..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
- Social and biomedical risk factors for multi-drug resistant TB in rural ChinaBiao Xu; Fiscal Year: 2010..It is imperative to find not only biological factors but also social factors that more distally fuel this ongoing epidemic. Results of this study can contribute directly to improving TB control strategies aimed at reducing MDR-TB. ..
- LIPOSOMAL S MUTANS DELIVERY SYSTEM FOR CARIES IMMUNITYNoel Childers; Fiscal Year: 2001....
- VIRULENCE FACTORS OF GROUP B STREPTOCOCCIJohn Bohnsack; Fiscal Year: 2001..This approach will ultimately contribute to understanding the molecular basis of disease caused by GBS, and help devise strategies for preventing and treating this important cause of serious human neonatal bacterial infection. ..
- Helicobacter induced hepatitis and tumorigenesisJames Fox; Fiscal Year: 2009..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
- Extracrevicular Invasion by Periodontal PathogensJOEL RUDNEY; Fiscal Year: 2005..abstract_text> ..
- High-throughput Sequencing by PyrosequencingMostafa Ronaghi; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Effects of Artemisinin on Leishmania SERCA pumpJOHN MEADE; Fiscal Year: 2008..cruzi and T. brucei SERCAs. [unreadable] [unreadable] [unreadable]..
- Clinical Impact of Quinolone-Resistant E.coli carriageEbbing Lautenbach; Fiscal Year: 2007..unreadable] [unreadable]..
- OmpR and acid regulation of Escherichia coli fim genesWILLIAM SCHWAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- IN VIVO STUDIES OF SALIVA ANTIMICROBIAL PROTEINSJOEL RUDNEY; Fiscal Year: 2001..By focusing on redundancy and complexing, this project also addresses the question of whether individual proteins exert unique and specific effects in the mouth. ..
- Tissue-Specific Infection by Group A StreptococciDEBRA BESSEN; Fiscal Year: 2007..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
- Proline uptake in staphylococcus aureus pathogenesisWILLIAM SCHWAN; Fiscal Year: 2002..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
- Quinolone resistant E coli in long term care facilitiesEbbing Lautenbach; Fiscal Year: 2009..abstract_text> ..
- Population genomics of Streptococcus pyogenesDEBRA BESSEN; Fiscal Year: 2009..abstract_text> ..
- Novel Application of Infection Control Strategies to Limit Transmission of ESBL'SEbbing Lautenbach; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Molecular Evolution of Resistance in Strep. pyogenesDEBRA BESSEN; Fiscal Year: 2005..GAS provide a sound model system for understanding the molecular evolution underlying the early stages of the emergence and global spread of antibiotic resistance. ..
- QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONSEbbing Lautenbach; Fiscal Year: 2004....
- EVOLUTION OF GROUP A STREPTOCOCCIDEBRA BESSEN; Fiscal Year: 2004..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
- PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONSDeborah Dean; Fiscal Year: 2004..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
- C. trachomatis genomics, strain typing, and evolutionDeborah Dean; Fiscal Year: 2008..unreadable] [unreadable]..
- Pathogenesis of Persistent Chlamydial STDsDeborah Dean; Fiscal Year: 2007..1 Description, ..