histological techniques

Summary

Top Publications

  1. pmc Identification of vertebra-like elements and their possible differentiation from sclerotomes in the hagfish
    Kinya G Ota
    Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Commun 2:373. 2011
  2. pmc An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed
    Bruce F Smith
    Scott Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Lab Invest 91:216-31. 2011
  3. pmc Transmission, diagnosis, and recommendations for control of Pseudoloma neurophilia infections in laboratory zebrafish (Danio rerio) facilities
    Katrina N Murray
    Zebrafish International Resource Center, University of Oregon, Eugene, Oregon, USA
    Comp Med 61:322-9. 2011
  4. ncbi Mosaicing of microscope images with global geometric and radiometric corrections
    Changming Sun
    CSIRO Mathematical and Information Sciences, Locked Bag 17, North Ryde, NSW 1670, Australia
    J Microsc 224:158-65. 2006
  5. pmc Diffusion and imaging properties of three new lipophilic tracers, NeuroVue Maroon, NeuroVue Red and NeuroVue Green and their use for double and triple labeling of neuronal profile
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 66:249-58. 2005
  6. ncbi Tissue microarray of head and neck squamous carcinoma: validation of the methodology for the study of cutaneous fatty acid-binding protein, vascular endothelial growth factor, involucrin and Ki-67
    Wafaey Gomaa
    Department of Pathology, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, UK
    Virchows Arch 447:701-9. 2005
  7. ncbi Amplification of tissue by construction of tissue microarrays
    D L Rimm
    Department of Pathology and the Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Exp Mol Pathol 70:255-64. 2001
  8. ncbi Nodavirus infections in Israeli mariculture
    M Ucko
    Israel Oceanographic and Limnological Research Ltd, National Center for Mariculture, Eilat, Israel
    J Fish Dis 27:459-69. 2004
  9. ncbi Sequential pathology after initial freshwater bath treatment for amoebic gill disease in cultured Atlantic salmon, Salmo salar L
    M B Adams
    School of Aquaculture, Aquafin CRC, Tasmanian Aquaculture and Fisheries Institute, Launceston, Tasmania, Australia
    J Fish Dis 27:163-73. 2004
  10. ncbi Identification of a serine protease gene expressed by Myxobolus cerebralis during development in rainbow trout Oncorhynchus mykiss
    Garry O Kelley
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Dis Aquat Organ 59:235-48. 2004

Detail Information

Publications271 found, 100 shown here

  1. pmc Identification of vertebra-like elements and their possible differentiation from sclerotomes in the hagfish
    Kinya G Ota
    Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Commun 2:373. 2011
    ..We conclude that the vertebra-like elements in the hagfish are homologous to gnathostome vertebrae, implying that this animal underwent secondary reduction of vertebrae in most of the trunk...
  2. pmc An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed
    Bruce F Smith
    Scott Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Lab Invest 91:216-31. 2011
    ..Affected puppies had a normal birth weight but they experienced a striking growth delay in the first 5 days. In summary, the new corgi DMD model offers an excellent opportunity to study DMD pathogenesis and to develop novel therapies...
  3. pmc Transmission, diagnosis, and recommendations for control of Pseudoloma neurophilia infections in laboratory zebrafish (Danio rerio) facilities
    Katrina N Murray
    Zebrafish International Resource Center, University of Oregon, Eugene, Oregon, USA
    Comp Med 61:322-9. 2011
    ..We then review current knowledge about P. neurophilia transmission and diagnosis. Considering this information, we present recommendations for control of P. neurophilia in zebrafish facilities...
  4. ncbi Mosaicing of microscope images with global geometric and radiometric corrections
    Changming Sun
    CSIRO Mathematical and Information Sciences, Locked Bag 17, North Ryde, NSW 1670, Australia
    J Microsc 224:158-65. 2006
    ..The input images were transformed using the estimated geometric and radiometric parameters and mosaiced together, producing accurate registration of overlapping regions without visible seams...
  5. pmc Diffusion and imaging properties of three new lipophilic tracers, NeuroVue Maroon, NeuroVue Red and NeuroVue Green and their use for double and triple labeling of neuronal profile
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 66:249-58. 2005
    ..Double labeling experiments using NeuroVue Red and eGFP allowed us to demonstrate that every fiber in the neonatal ear is surrounded by developing Schwann cells...
  6. ncbi Tissue microarray of head and neck squamous carcinoma: validation of the methodology for the study of cutaneous fatty acid-binding protein, vascular endothelial growth factor, involucrin and Ki-67
    Wafaey Gomaa
    Department of Pathology, University of Liverpool, Duncan Building, Daulby Street, Liverpool, L69 3GA, UK
    Virchows Arch 447:701-9. 2005
    ..Concordance with whole-tissue section data is reassuring, but data from microarrays need to be validated against clinical outcomes...
  7. ncbi Amplification of tissue by construction of tissue microarrays
    D L Rimm
    Department of Pathology and the Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Exp Mol Pathol 70:255-64. 2001
    ..It has the potential for allowing validation of new genes at a speed comparable to the rapid rate of gene discovery afforded by DNA microarrays...
  8. ncbi Nodavirus infections in Israeli mariculture
    M Ucko
    Israel Oceanographic and Limnological Research Ltd, National Center for Mariculture, Eilat, Israel
    J Fish Dis 27:459-69. 2004
    ..Red Sea and Mediterranean isolated sequences grouped in distinct clusters, together with several foreign isolates from the Mediterranean area and the Far East, as phylogenetically close to the Epinephelus akaara RGNNV type...
  9. ncbi Sequential pathology after initial freshwater bath treatment for amoebic gill disease in cultured Atlantic salmon, Salmo salar L
    M B Adams
    School of Aquaculture, Aquafin CRC, Tasmanian Aquaculture and Fisheries Institute, Launceston, Tasmania, Australia
    J Fish Dis 27:163-73. 2004
    ..was noted. We conclude that pathogenesis during the inter-bath period was identical to initial infection although the source of re-infection remains to be established...
  10. ncbi Identification of a serine protease gene expressed by Myxobolus cerebralis during development in rainbow trout Oncorhynchus mykiss
    Garry O Kelley
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Dis Aquat Organ 59:235-48. 2004
    ..Identifying genes encoding these enzymes and characterization of their functions can lead to the development of new chemotherapeutic protocols and vaccine approaches to control parasitic diseases...
  11. ncbi Effects of the gill monogenean Zeuxapta seriolae (Meserve, 1938) and treatment with hydrogen peroxide on pathophysiology of kingfish, Seriola lalandi Valenciennes, 1833
    B Mansell
    Tasmanian Aquaculture and Fisheries Institute, School of Aquaculture, University of Tasmania, Launceston, Tasmania, Australia
    J Fish Dis 28:253-62. 2005
    ..g. lactate, osmolality) and extent of the effects (e.g. haemoglobin) was much less than that caused by chronic infection with Z. seriolae...
  12. ncbi Lernanthropus kroyeri infections in farmed sea bass Dicentrarchus labrax: pathological features
    Maurizio Manera
    Department of Food Science, University of Teramo, Piazza Aldo Moro, 45, 64100 Teramo, Italy
    Dis Aquat Organ 57:177-80. 2003
    ..Parasitism by L. kroyeri affected the host's condition factor (mean +/- SE in uninfected vs parasitized; 1.88 +/- 0.04 vs 1.66 +/- 0.12; p < 0.05)...
  13. ncbi heart of glass regulates the concentric growth of the heart in zebrafish
    John D Mably
    Cardiovascular Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 13:2138-47. 2003
    ..In heart of glass mutant embryos, the number of cells in the myocardium is normal, but they are not added in the concentric direction. As a consequence, the chambers are huge and dysfunctional, and the myocardium remains a single layer...
  14. ncbi Zebrafish periostin is required for the adhesion of muscle fiber bundles to the myoseptum and for the differentiation of muscle fibers
    Hisaaki Kudo
    Department of Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Dev Biol 267:473-87. 2004
    ....
  15. ncbi Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice
    WenFang Wang
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02215, USA
    Dev Biol 270:364-81. 2004
    ..We therefore conclude that Grg5 enhances Runx2 activity in vivo...
  16. ncbi Development of a cost-effective oral vaccination method against viral disease in fish
    A R Companjen
    Wageningen University and Research Centre Department of Animal Sciences, Cell Biology and Immunology Group, The Netherlands
    Dev Biol (Basel) 121:143-50. 2005
    ..The results further indicated that a specific humoral immune response was evoked...
  17. ncbi Important disease conditions of newly cultured species in intensive freshwater farms in Greece: first incidence of nodavirus infection in Acipenser sp
    F Athanassopoulou
    Laboratory of Ichthyology, Fish Diseases and Aquaculture, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece
    Dis Aquat Organ 60:247-52. 2004
    ..and Myxobacteria spp. Tilapia were very susceptible to gas bubble disease and A. hydrophila. This bacterium was associated with management manipulations for all species and fully responsive to corrective hygiene methods...
  18. ncbi Intracellular infection with Spironucleus barkhanus (Diplomonadida: Hexamitidae) in farmed Arctic char Salvelinus alpinus
    Erik Sterud
    National Veterinary Institute, PO Box 8156 Dep, 0033 Oslo, Norway
    Dis Aquat Organ 56:155-61. 2003
    ..The relatively few gross and histopathological lesions may indicate that Arctic char are more tolerant to this parasite than Atlantic salmon...
  19. ncbi Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
    Reiko Hanada
    Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0861, Japan
    Nat Med 10:1067-73. 2004
    ..These characteristic functions of NMU may provide new insight for understanding the pathophysiological basis of obesity...
  20. ncbi Immunohistochemistry, histopathology and ultrastructure of Gasterosteus aculeatus tissues infected with Glugea anomala
    B S Dezfuli
    Department of Biology, University of Ferrara, Via Borsari, 46, 44100 Ferrara, Italy
    Dis Aquat Organ 58:193-202. 2004
    ..Specifically, the protozoan induces a response in the stickleback nervous system, the reaction of which is revealed through the application of immunohistochemical techniques...
  21. ncbi Acute and persistent experimental nodavirus infection in spotted wolffish Anarhichas minor
    R Johansen
    National Veterinary Institute, PO Box 8156, 0033 Oslo, Norway
    Dis Aquat Organ 57:35-41. 2003
    ..Nodavirus was reisolated from fish at the last sampling in SSN-1 cells, showing that nodavirus retains virulence in persistently infected wolffish for at least 16 wk post-bath-challenge...
  22. ncbi A microsporidian parasite of the genus Spraguea in the nervous tissues of the Japanese anglerfish Lophius litulon
    Mark A Freeman
    Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo, Tokyo 113 8657, Japan
    Folia Parasitol (Praha) 51:167-76. 2004
    ..This report of Spraguea americana is the first report of a Spraguea species from L. litulon and indeed from the Pacific water mass...
  23. ncbi The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation
    Daniel Mesnard
    Wellcome Trust Cancer Research Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Curr Biol 14:184-96. 2004
    ..When the anterior-posterior axis of the mouse embryo becomes explicit at gastrulation, it is almost perpendicular to the long uterine axis. This led to the belief that the uterus could play a key role in positioning this future body axis...
  24. ncbi Changes in the innate immune response of Atlantic salmon, Salmo salar L., exposed to experimental infection with Neoparamoeba sp
    K A Gross
    Tasmanian Aquaculture and Fisheries Institute and Aquafin CRC, School of Aquaculture, University of Tasmania, Launceston, Tasmania, Australia
    J Fish Dis 28:293-9. 2005
    ..There was an increase in the chemotactic response of anterior kidney macrophages isolated from exposed fish relative to control fish at 8 dpe. Total protein and lysozyme levels were not affected by Neoparamoeba sp. exposure...
  25. ncbi A parasite survey of farmed Southern bluefin tuna, Thunnus maccoyii (Castelnau)
    M R Deveney
    PIRSA Aquaculture, Primary Industries and Resources South Australia and Aquafin CRC, Adelaide, SA 5001, Australia
    J Fish Dis 28:279-84. 2005
    ..Targeted screening for U. nigricans exposed a low prevalence, most probably due to a lack of sensitivity in the test method. Few of the parasites examined pose a risk to the health of farmed SBT...
  26. ncbi Gross pathology and its relationship with histopathology of amoebic gill disease (AGD) in farmed Atlantic salmon, Salmo salar L
    M B Adams
    School of Aquaculture, Aquafin CRC, Tasmanian Aquaculture and Fisheries Institute, Launceston, Tasmania, Australia
    J Fish Dis 27:151-61. 2004
    ..It was concluded that clinical diagnosis is acceptable as a farm-monitoring tool only. Removal of grossly affected tissue and subsequent histological examination is recommended to improve diagnostic accuracy...
  27. ncbi Control of Salmincola californiensis (Copepoda: Lernaeapodidae) in rainbow trout, Oncorhynchus mykiss (Walbaum): a clinical and histopathological study
    R J Roberts
    University of Idaho, Center for Sustainable Aquaculture, Hagerman Fish Culture Experiment Station, Hagerman, ID 83332, USA
    J Fish Dis 27:73-9. 2004
    ..The use of oral dosage with ivermectin is an effective treatment for S. californiensis and could be particularly beneficial for use with endangered salmon broodstocks infested with the parasite...
  28. ncbi Cryptosporidium scophthalmi n. sp. (Apicomplexa: Cryptosporidiidae) from cultured turbot Scophthalmus maximus. Light and electron microscope description and histopathological study
    P Alvarez-Pellitero
    Instituto de Acuicultura Torre de la Sal, Consejo Superior de Investigaciones Cientificas, Ribera de Cabanes, 12595 Castellon, Spain
    Dis Aquat Organ 62:133-45. 2004
    ..An inflammatory reaction involving leucocyte infiltration was sometimes observed...
  29. ncbi Introduction and comparison of two methods of assessment of coronary lesions in Atlantic salmon, Salmo salar L
    S L Seierstad
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Fish Dis 28:189-97. 2005
    ..5%. The semi-quantitative method was a valid and reliable method for coronary lesion evaluation in Atlantic salmon...
  30. ncbi Pseudocohnilembus persalinus (Ciliophora: Scuticociitida) is an additional species causing scuticociliatosis in olive flounder Paralichthys olivaceus
    Sung Mi Kim
    Department of Aquatic Life Medicine, Pukyong National University, Pusan 608 737, Korea
    Dis Aquat Organ 62:239-44. 2004
    ..These data suggest that the multiplex PCR procedure would make it possible to avoid the cumbersome and time-consuming procedures of morphological analysis for the definitive identification of ciliates...
  31. ncbi Occurrence of scuticociliatosis in olive flounder Paralichthys olivaceus by Phiasterides dicentrarchi (Ciliophora: scuticociliatida)
    Sung Mi Kim
    Department of Aquatic Life Medicine, Pukyong National University, Pusan 608 737, Korea
    Dis Aquat Organ 62:233-8. 2004
    ..dicentrarchi, and sequenced the SS rRNA gene in order to design P. dicentrarchi specific primers. This is the first report on scuticociliatosis caused by P. dicentrarchi from marine fish in Asia...
  32. ncbi Evolution of OTP-independent larval skeleton patterning in the direct-developing sea urchin, Heliocidaris erythrogramma
    Na Zhou
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    J Exp Zool B Mol Dev Evol 300:58-71. 2003
    ..erythrogramma. OTP plays an important role in patterning the larval skeleton of H. tuberculata, but this role apparently has been lost in the evolution of the H. erythrogramma larva, and replaced by a new patterning mechanism...
  33. pmc The role of Axin2 in calvarial morphogenesis and craniosynostosis
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Development 132:1995-2005. 2005
    ..The craniofacial anomalies caused by the Axin2 mutation are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis...
  34. ncbi Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure
    Stephanie Brewer
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Dev Biol 267:399-417. 2004
    ..These findings provide a fundamental understanding of how AP-2alpha functions in the closure of the ventral body wall, as well as offer insight into related human birth defects...
  35. ncbi Regulation of neuroD2 expression in mouse brain
    Chin Hsing Lin
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 265:234-45. 2004
    ....
  36. ncbi Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired development
    Celine Bry
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Biol 267:418-29. 2004
    ..Cx26 is considered a tumor suppressor gene and Cx26-null mammary tissue was evaluated after five pregnancies. No hyperproliferation or hyperplasia was observed, suggesting that Cx26 does not function as a tumor suppressor...
  37. ncbi Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice
    Dagmara A Dettlaff-Swiercz
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Dev Biol 282:174-82. 2005
    ..In contrast, ET-3/ET(B)-mediated development of neural crest-derived melanocytes and enteric neurons appears to involve G-proteins different from G(q)/G(11)/G(12)/G(13)...
  38. ncbi Gonadal structure of the serial-sex changing gobiid fish Trimma okinawae
    Yasuhisa Kobayashi
    Sesoko Station, Tropical Biosphere Research Center, University of the Ryukyus, 3422 Sesoko, Motobu cho, Okinawa 905 0227, Japan
    Dev Growth Differ 47:7-13. 2005
    ..In the testis, moderate immunopositive signals were obtained from dual-phase male/females...
  39. ncbi Development of the mammalian urethra is controlled by Fgfr2-IIIb
    Anita Petiot
    Cancer Research UK, Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 132:2441-50. 2005
    ..This represents the first example of how the developing genitourinary system integrates cues from systemically circulating steroid hormones with a locally expressed growth factor pathway...
  40. pmc Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 18:2469-73. 2004
    ..These results demonstrate that vascular remodeling in the mouse embryo is sensitive to Dll4 gene dosage and that Notch activation in endothelial cells is essential for embryonic vascular remodeling...
  41. ncbi Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types
    Susan E Schonhoff
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Boston, MA 02111, USA
    Dev Biol 270:443-54. 2004
    ..Thus, ngn3 expression occurs in mixed populations of immature cells that are not irreversibly committed to endocrine differentiation...
  42. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    ..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia...
  43. ncbi Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility
    Guanghu Wang
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia
    Genesis 38:66-80. 2004
    ..The findings suggest that additive or synergistic transcriptional activity of both hsf1 and hsf2 is required for normal mammalian spermatogenesis and male fertility...
  44. ncbi Smad2 and Smad3 coordinately regulate craniofacial and endodermal development
    Ye Liu
    Program in Molecular, Cellular, and Developmental Biology, Ohio State University, Columbus, OH 43210 1392, USA
    Dev Biol 270:411-26. 2004
    ..This precedes any defects in anterior patterning and likely causes the abnormalities observed in craniofacial and midline development, as well as hepatogenesis...
  45. ncbi The mammalian twisted gastrulation gene functions in foregut and craniofacial development
    Anna Petryk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
    Dev Biol 267:374-86. 2004
    ..In addition, we find defects in the foregut endoderm and a reduction in Hex expression, which may contribute to both the forebrain and BA1 defects...
  46. ncbi Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    Loydie A Jerome-Majewska
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Dyn 234:922-33. 2005
    ....
  47. ncbi Characterization and molecular methods for detection of a novel spiroplasma pathogenic to Penaeus vannamei
    Linda M Nunan
    Department of Veterinary Sciences and Microbiology, University of Arizona, Tucson, Arizona, 85721, USA
    Dis Aquat Organ 62:255-64. 2004
    ..a digoxigenin-labeled probe was developed and tested. This probe was species-specific, with no positive reactions or cross-reactivity occurring with other bacterial samples tested in this format...
  48. ncbi Efficacy and toxicity of orally administrated anti-coccidial drugs for innovative treatments of Myxobolus sp. infection in Puntazzo puntazzo
    F Athanassopoulou
    Laboratory of Ichthyology and Fish Pathology, University of Thessaly, Faculty of Veterinary Medicine, School of Health Sciences, 221 Trikalon Street, 431 00 Karditsa, Greece
    Dis Aquat Organ 62:217-26. 2004
    ..The SA combination proved the most effective treatment for Myxobolus sp. infection of P. puntazzo as (1) the therapeutic regimen and commercial product was not toxic and (2) a significant reduction occurred in the prevalence rate...
  49. ncbi Experimental infection of turbot, Scophthalmus maximus (L.), by Moritella viscosa, vaccination effort and vaccine-induced side-effects
    B Bjornsdottir
    Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavik, Iceland
    J Fish Dis 27:645-55. 2004
    ..The measurement of various innate humoral immune parameters did not reveal significant differences between vaccinated and control groups...
  50. ncbi Heart and skeletal muscle inflammation in Atlantic salmon, Salmo salar L: a new infectious disease
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    J Fish Dis 27:351-8. 2004
    ..Further investigations are required in order to make conclusions regarding the cause and pathogenesis of HSMI...
  51. ncbi Pathology of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 59:217-24. 2004
    ..Microscopic lesions are compared and discussed in relation to published descriptions of pancreas disease (PD) and cardiomyopathy syndrome (CMS). It is concluded that HSMI is histopathologically distinguishable from PD and CMS...
  52. ncbi Isolation of a rhabdovirus during outbreaks of disease in cyprinid fish species at fishery sites in England
    K Way
    Centre for the Environment, Fisheries and Aquaculture Science Cefas, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 57:43-50. 2003
    ..The field observations together with the experimental results indicate that this rhabdovirus is of low virulence but may have the potential to cause significant mortality in fishes under stress...
  53. ncbi Assessment of DNA vaccine potential for gilthead sea bream (Sparus aurata) by intramuscular injection of a reporter gene
    Tiziano Verri
    Department of Biological and Environmental Sciences and Technologies, University of Lecce, Via provinciale Lecce Monteroni, I 73100, Lecce, Italy
    Fish Shellfish Immunol 15:283-95. 2003
    ..i. The results suggest that intramuscular delivery of foreign genes represents a realistic approach for DNA vaccine technology for the prevention of infectious diseases in gilthead sea bream...
  54. ncbi Studies on transmission and life cycle of Enteromyxum scophthalmi (Myxozoa), an enteric parasite of turbot Scophthalmus maximus
    Maria J Redondo
    Instituto de Acuicultura de Torre de la Sal CSIC, Ribera de Cabanes, 12595 Castellon, Spain
    Folia Parasitol (Praha) 51:188-98. 2004
    ..This may also question the existence of a two-host life cycle involving an actinosporean stage in this species. Further studies are needed to clarify this open point of the life cycle...
  55. ncbi Polymicrobic infection of hybrid striped bass (Morone chrysops x Morone saxatilis) with three bacterial pathogens: a case report
    P R Bowser
    Aquatic Animal Health Program, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    J Fish Dis 27:123-7. 2004
  56. ncbi Defeating diplostomoid dangers in USA catfish aquaculture
    Robin M Overstreet
    Department of Coastal Sciences, The University of Southern Mississippi, P O Box 7000, Ocean Springs, Mississippi 9566 7000, USA
    Folia Parasitol (Praha) 51:153-65. 2004
    ..Consequently, management of catfish ponds relative to digenean infections requires considerable biological information on the fish, bird, and snail hosts as well as the parasites...
  57. ncbi In vitro efficacy of new antiprotozoals against Philasterides dicentrarchi (Ciliophora, Scuticociliatida)
    A Parama
    Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Dis Aquat Organ 62:97-102. 2004
    ..The most promising compound was the pyridothienotriazine 12k, with activity similar to that of the salicylanilides niclosamide and oxiclozanide (MLC 0.8 mg l(-1) in PBS, 1.5 mg l(-1) in seawater; MLC = minimum 24 h lethal concentration)...
  58. ncbi Pseudomonas anguilliseptica infection in farmed cod, Gadus morhua L
    H W Ferguson
    Veterinary Diagnostic Service, Institute of Aquaculture, University of Stirling, Stirling, UK
    J Fish Dis 27:249-53. 2004
  59. ncbi The pathology of chronic erosive dermatopathy in Murray cod, Maccullochella peelii peelii (Mitchell)
    J E Baily
    Institute of Aquaculture, University of Stirling, Stirling, UK
    J Fish Dis 28:3-12. 2005
    ..Canal regeneration occurred when fish were transferred from borehole water into river water. The lack of lesions in other organs and the pattern of lesion development support exposure to waterborne factors as the most likely aetiology...
  60. ncbi Susceptibility of captive adult winter-run Chinook salmon Oncorhynchus tshawytscha to waterborne exposures with infectious hematopoietic necrosis virus (IHNV)
    K D Arkush
    Bodega Marine Laboratory, University of California at Davis, PO Box 247, Bodega Bay, California 94923, USA
    Dis Aquat Organ 59:211-6. 2004
    ....
  61. ncbi Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury
    S P Jones
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Am J Physiol Heart Circ Physiol 279:H2196-201. 2000
    ..PMN accumulation in the ischemic-reperfused (I/R) zone was assessed using histological techniques. Deficiencies of P-selectin, E-selectin, ICAM-1, or CD18 resulted in significant (P < 0...
  62. ncbi [Fluorescence serologic and histologic studies of antigen distribution in parvovirus infections in dogs and cats]
    H Weissenbock
    Institut für Pathologie und Gerichtliche Veterinärmedizin der Veterinärmedizinischen Universität Wien
    Zentralbl Veterinarmed B 38:481-91. 1991
    ....
  63. ncbi Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction
    J E Dawson
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 65:603-9. 2001
    ..Significantly, in 2 of these patients, serologic evidence of infection was absent. Use of IHC, ISH, and PCR to visualize and detect Ehrlichia in tissues can facilitate diagnosis of ehrlichial infections...
  64. ncbi Monkey pulpal response to an MMA-based resin cement as adhesive luting for indirect restorations
    Yasushi Shimada
    Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Adhes Dent 7:247-51. 2005
    ..The objective of this study was to evaluate the pulpal response to a newly-developed MMA resin cement (MultiBond, Tokuyama) when used for adhesively luting composite resin inlays...
  65. pmc A biological global positioning system: considerations for tracking stem cell behaviors in the whole body
    Shengwen Calvin Li
    Center for Neuroscience and Stem Cell Research, Children s Hospital of Orange County Research Institute, University of California Irvine, 455 South Main Street, Orange, CA 92868, USA
    Stem Cell Rev 6:317-33. 2010
    ..Even though excellent histological techniques remain as the gold standard, no good in vivo techniques are currently available to assess the ..
  66. ncbi Neural control of shark rectal gland
    J S Stoff
    Mount Desert Island Biological Laboratory, Salsbury Cove, Maine 04672
    Am J Physiol 255:R212-6. 1988
    ..Vasoactive intestinal peptide (VIP)-like immunoreactivity was detected by histological techniques in neuronal tissue within the rectal gland...
  67. ncbi Ultrastructural aspects of the microvasculature of the cochlea: the internal spiral network
    R Penha
    Department of Otorhinolaryngology, Hospital Egas Moniz, Lisbon, Portugal
    Otolaryngol Head Neck Surg 120:725-9. 1999
    ..The comparison of results obtained with each technique gave the perspective of the cochlear microvasculature with great accuracy...
  68. ncbi The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system
    Arnon D Jurberg
    Laboratorio de Patologia, Instituto Oswaldo Cruz Fundação Oswaldo Cruz, Pavilhão Gomes de Faria Av Brasil, 4365 Manguinhos, Rio de Janeiro 21040 900, RJ, Brazil
    Dev Genes Evol 219:219-34. 2009
    ..Using classical histological techniques and whole-mount preparations, the present work describes the embryonic development of Schistosoma mansoni ..
  69. ncbi Identification of immunodominant autoantigens in rat autoimmune orchitis
    Monika Fijak
    Department of Anatomy and Cell Biology, Justus Liebig University of Giessen, D 35385 Giessen, Germany
    J Pathol 207:127-38. 2005
    ..Development of disease was observed using histological techniques and a new non-invasive three-dimensional (3D) imaging technology for in vivo monitoring, termed flat-..
  70. ncbi Warthin tumor: a curious entity--case reports and review of literature
    Alexandra Faur
    Department of Pathology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Rom J Morphol Embryol 50:269-73. 2009
    ..the histopathological aspect of Warthin tumors using Hematoxylin-Eosin stain, and immunohistochemical and histological techniques. We reviewed the medical record of patients with salivary gland tumors diagnosed at County Hospital of ..
  71. ncbi Histological approaches for high-quality imaging of zooplanktonic organisms
    Rossana C N Melo
    Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, UFJF, Juiz de Fora, MG, Brazil
    Micron 38:714-21. 2007
    ..can play a structural function as indicators for ecosystem health or stress, but their study using histological techniques is still limited...
  72. ncbi Interstitial laser hyperthermia for colorectal liver metastases: the effect of thermal sensitization and the use of a cylindrical diffuser tip on tumor necrosis
    V Muralidharan
    Department of Surgery, Monash University, Alfred Hospital, Prahran, Australia
    J Clin Laser Med Surg 20:189-96. 2002
    ..The potential synergistic effect between thermal sensitization by metronidazole and interstitial laser hyperthermia (ILH)-induced tumor necrosis is also evaluated...
  73. ncbi Delayed sclerosis, neuroprotection, and limbic epileptogenesis after status epilepticus in the rat
    Ulrich Ebert
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Epilepsia 43:86-95. 2002
    ..e., the development of recurrent spontaneous seizures) during the following weeks...
  74. ncbi Mild carbon monoxide exposure diminishes selectively the integrity of the cochlea of the developing rat
    Ivan Lopez
    Surgery Department, Division of Head and Neck, David Geffen School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 74:666-75. 2003
    ..and the neurons of the spiral ganglion were analyzed for their morphology by using immunochemical and histological techniques. The inner and outer hair cells in the organ of Corti of animals exposed to 12 and 25 ppm CO were not ..
  75. ncbi Three-dimensional MR microscopy of a transgenic mouse model of dilated cardiomyopathy
    R W Sze
    Department of Radiology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Pediatr Radiol 31:55-61. 2001
    ..b>Histological techniques, although providing great anatomic detail, display only "static" data (one time point only) in two ..
  76. ncbi A comparative study on cardiac ganglia in midday gerbil, Egyptian spiny mouse, chinchilla laniger and pigeon
    T Kuder
    Department of Comparative Anatomy, Institute of Biology, Swietokrzyski University, 25 406 Kielce, 15 Swietokrzyska St, Poland
    Anat Histol Embryol 32:134-40. 2003
    Using the thiocholine method and histological techniques, the topography and morphology of cardiac ganglia in midday gerbil, Egyptian spiny mouse, chinchilla laniger and pigeon were studied...
  77. ncbi The AChE-positive ganglia in the trachea and bronchi of the cat
    Tadeusz Kuder
    Department of Comparative Anatomy, Institute of Biology, Swietokrzyski University, Kielce, Poland
    Folia Morphol (Warsz) 62:99-106. 2003
    ..ganglia in the cat were studied using the histochemical-tiocholine method of Koelle and Friedenwald and histological techniques. Intensively stained AChE-positive nerve structures, i.e...
  78. ncbi Impact of heterophil granulocyte depletion caused by 5-fluorouracil on infectious bursal disease virus infection in specific pathogen free chickens
    Susanne Kabell
    Danish Institute for Food and Veterinary Research, Hangøvej 2, DK 8200 Aarhus N, Denmark
    Avian Pathol 35:341-8. 2006
    ..of Fabricius were sampled at fixed intervals, and the progress of the infection was monitored by various histological techniques and reverse transcriptase-polymerase chain reaction (RT-PCR)...
  79. ncbi Structural degeneration of pulmonary homografts used as aortic valve substitute underlines early graft failure
    Dave R Koolbergen
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cardiothorac Surg 22:802-7. 2002
    ..The mid-term results are evaluated in this study and histological analysis of explanted homografts is performed to investigate the cause of graft failure...
  80. ncbi Geographical location and age affects the incidence of parasitic infestations in school children
    Paran Rayan
    School of Biomolecular and Biomedical Sciences, Griffith University, Kessels Road, Nathan, Brisbane, Queensland 4111, Australia
    Indian J Pathol Microbiol 53:498-502. 2010
    ..socio-economic zones (rural and urban) were screened for specific intestinal parasites using standard histological techniques. Percentage incidences of parasitic species found in fecal wet mounts and concentrates in rural children ..
  81. ncbi Evolution of mammalian X-chromosome inactivation: sex chromatin in monotremes and marsupials
    L M McKay
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Vic
    Aust J Biol Sci 40:397-404. 1987
    ..possum, Trichosurus vulpecula) and monotremes (platypus, Ornithorynchus anatinus), using classical histological techniques. A female-specific chromatin body was observed at low frequency in nuclei of possum corneal epithelium, ..
  82. ncbi Widespread occurrence of the amphibian chytrid fungus Batrachochytrium dendrobatidis in the southeastern USA
    Betsie B Rothermel
    Austin Peay State University, The Center of Excellence for Field Biology, PO Box 4718, Clarksville, Tennessee 37044, USA
    Dis Aquat Organ 82:3-18. 2008
    ..Using histological techniques or PCR assays, we detected chytrid infection in 10 species of aquatic-breeding amphibians in 6 states...
  83. pmc A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    FASEB J 22:3310-7. 2008
    ..Biochemical, molecular, and histological techniques were used to examine the role of uPA and uPAR in the regulation of retinal vascular permeability in ..
  84. ncbi Computer-assisted complete three-dimensional reconstruction of the mammary ductal/lobular systems: implications of ductal anastomoses for breast-conserving surgery
    T Ohtake
    The Second Department of Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
    Cancer 91:2263-72. 2001
    ....
  85. ncbi Novel borate glass/chitosan composite as a delivery vehicle for teicoplanin in the treatment of chronic osteomyelitis
    Wei Tao Jia
    Department of Orthopedic Surgery, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    Acta Biomater 6:812-9. 2010
    ..pellets for treating osteomyelitis was evaluated using hematological, radiological, microbiological and histological techniques. When immersed in PBS, the TBGC pellets provided a sustained release of teicoplanin, while the surface of ..
  86. ncbi Histological studies of pedicle skin formation and its transformation to antler velvet in red deer (Cervus elaphus)
    C Li
    AgResearch, Invermay Agricultural Centre, Private Bag 50034, Mosgiel, New Zealand
    Anat Rec 260:62-71. 2000
    ..In the present study, we used histological techniques to examine pedicle skin formation and its transformation to antler velvet...
  87. ncbi The effects of soy extract on the uterus of castrated adult rats
    Rejane Mosquette
    Department of Gynecology, Federal University of Sao Paulo, Rua Sena Madureira 1245, 04021051 São Paulo, Brazil
    Maturitas 56:173-83. 2007
    ..The aim of this study was to evaluate the effects of different doses of a standardized soy extract on the uterus of castrated rats...
  88. ncbi Interactions between anomalous excretory and tegumental epithelia in aberrant Mesocestoides tetrathyridia from Apodemus sylvaticus in Spain
    David Bruce Conn
    Department of Invertebrate Zoology, Museum of Comparative Zoology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
    Parasitol Res 106:1109-15. 2010
    ..of Apodemus sylvaticus (Rodentia: Muridae) in Murcia, Spain, and processed by routine microscopical and histological techniques, including examination with brightfield, phase-contrast, and differential-interference-contrast optics...
  89. ncbi Imaging vitreous
    J Sebag
    Associate Clinical Professor of Ophthalmology Doheny Eye Institute Keck School of Medicine University of Southern California CA 92648, USA
    Eye (Lond) 16:429-39. 2002
    ..The combined use of more than one technique could provide better imaging of vitreous for future investigational and clinical purposes...
  90. ncbi The application of amino acid racemization in the acid soluble fraction of enamel to the estimation of the age of human teeth
    R C Griffin
    BioArch, Department of Archaeology, University of York, Heslington YO10 5DD, UK
    Forensic Sci Int 175:11-6. 2008
    ..The majority of existing morphological and histological techniques are highly inaccurate, and show a bias towards underestimating the age of older individuals...
  91. ncbi Principles of rat subcortical forebrain organization: a study using histological techniques and multiple fluorescence labeling
    A Riedel
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    J Chem Neuroanat 23:75-104. 2002
    ....
  92. pmc Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations
    Sarah Cormier
    Institut National de la Santé et de la Recherche Médicale U426, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Am J Pathol 161:1325-35. 2002
    ..21 and 8 thanatophoric dysplasia types 1 and 2, respectively) and 14 age-matched controls by histological techniques and in situ hybridization using riboprobes for human IHH, PTHR1, type 10 and type 1 collagen transcripts...
  93. ncbi Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's disease
    Jonathan D Thiessen
    Division of Neurodegenerative Disorders, St Boniface Research Centre, Winnipeg, MB, R2H 2A6, Canada
    Brain Struct Funct 215:29-36. 2010
    ..In our study, we used DWI in the TgCRND8 transgenic model of Alzheimer's disease in conjunction with histological techniques and found robust plaque deposition in the transgenic strain in older animals (12-16 months old)...
  94. ncbi Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model
    Nongnut Uabundit
    Department of Physiology Neuroscience Program and Graduate School, Faculty of Medicine, Khon Kaen University, Thailand
    J Ethnopharmacol 127:26-31. 2010
    ..Therefore, the potential of this plant to protect against Alzheimer's disease has been raised but less supported document is available...
  95. ncbi Immunohistochemical expression of fibronectin and tenascin after direct pulp capping with calcium hydroxide
    Evandro Piva
    Department of Operative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e66-71. 2006
    ..In the exposure site, TNC immunostaining increased over time, exhibiting a thicker immunostaining pattern within 30 days. The imunohistochemical technique showed expression of both glycoproteins during pulp healing process...
  96. ncbi [Spermatogenesis--physiology and pathophysiology]
    M Bergmann
    Institut für Veterinär Anatomie, Histologie und Embryologie, Universitat, Giessen
    Urologe A 44:1131-2, 1134-8. 2005
    ..Histological evaluation should be performed using a score count system, and the use of histological techniques for protein and mRNA expression...
  97. ncbi Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during chronic intoxication in the rat
    Eduardo M Becerra-Verdin
    Departamento de Histologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave Madero y Eduardo Aguirre Pequeño, A P 1563 Monterrey, Nuevo Leon, Mexico
    Toxicon 53:645-51. 2009
    ..We considered it important to evaluate, with histological techniques, the possible presence of lesions in the brain, by using a model of chronic intoxication that reproduces ..
  98. pmc Laryngeal epithelial thickness: a comparison between optical coherence tomography and histology
    M L Kaiser
    Department of Surgery, University of California Irvine, Orange, CA 92612, USA
    Clin Otolaryngol 34:460-6. 2009
    ..The purpose of our study is to measure normal laryngeal epithelial thickness by in vivo optical coherence tomography, and compare these values to those obtained from fixed ex-vivo laryngectomy specimens...
  99. ncbi Stimulation of implant fixation by parathyroid hormone (1-34)-A histomorphometric comparison of PMMA cement and stainless steel
    Ralf Skripitz
    Orthopaedic Department, University Hospital Eppendorf, Hamburg, Germany
    J Orthop Res 23:1266-70. 2005
    ..The tibial segments around the hole of the rods were then prepared by standard histological techniques. The linear tissue surfaces, that had been in contact with the surface of the rod, were analyzed in a ..
  100. pmc In vivo observations of cell trafficking in allotransplanted vascularized skin flaps and conventional skin grafts
    Benjamin M Horner
    Plastic Surgery Research Laboratory, Department of Surgery, WAC 435, Massachusetts General Hospital, Boston, MA 02114, USA
    J Plast Reconstr Aesthet Surg 63:711-9. 2010
    ..examining skin rejection has mainly studied rejection of conventional skin grafts (CSG) using standard histological techniques. The aim of this study was to objectively assess if there were differences in the immune response to CSG ..
  101. ncbi Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression
    G G Kinney
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Sleep Research Laboratory at the Georgia Mental Health Institute, N E Atlanta, GA 30306, USA
    Brain Res 756:68-75. 1997
    ..testing 'depressed' rats at both 2 and 3 months of age, and verifying electrode location using standard histological techniques. We found that DRN unit firing in 'depressed' rats (0.417 +/- 0...

Research Grants62

  1. The role of NFAT in podocyte damage and proteinuric kidney disease
    ALEXIS JOANNA SLOAN; Fiscal Year: 2013
    ..Interestingly, the glomerulus appears normal under histological techniques such as hematoxylin and eosin (H+E) staining and periodic acid Schiff staining (PAS)...
  2. Disordered Cellular Cholesterol Movement, Cell Death, and Multisystem Disease
    STEPHEN DEAN TURLEY; Fiscal Year: 2013
    ..In addition, histological techniques, coupled with measurements of the mRNA expression of proteins reflecting macrophage invasion and ..
  3. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..This project will study how to maximize the stocks of these cells and ensure their safe use in cell therapy. ..
  4. The Role of Macrophage Migration Inhibitory Factor in Osteoarthritis
    MEREDITH A GREENE; Fiscal Year: 2013
    ..We will also use histological techniques to analyze the effects of matrix degradation and to compare the macrophage populations in both the aged ..
  5. Mechanisms of Hypertension-induced Renal Injury
    Allen W Cowley; Fiscal Year: 2010
    ..b>Histological techniques and immunostaining will be utilized to quantify the degree of tissue injury...
  6. Genetic Dissection of Age-dependent Neuroprotection Mechanisms in Drosophila
    BARRY S GANETZKY; Fiscal Year: 2013
    ..are to determine the in vivo roles of the affected proteins using genetic, molecular, biochemical, and histological techniques to analyze how defects in these proteins result in the observed phenotypes...
  7. Pathophysiology of Biphosphonate-Induced ONJ in a Novel Animal Model
    J Ignacio Aguirre; Fiscal Year: 2010
    ..the removal of necrotic bone by the assessment of necrotic bone accumulation using histochemical/histological techniques, and also on indices of bone resorption by using quantitative histomorphometry;3) new bone formation and ..
  8. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ..b>Histological techniques will be used to classify plaque stages...
  9. Activation of the Trigeminovascular Pathway
    Rami Burstein; Fiscal Year: 2011
    ..recording to study A5 and C-fiber meningeal nociceptors and central trigeminovascular neurons, and histological techniques to study morphological and biochemical changes in the dura...
  10. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2013
    ..We will also use histological techniques to determine the affects of Atoh1 deletion on adult Merkel cells and how this deletion impacts the ..
  11. Corticostriatal networks and NMDAR mediation of habitual and flexible action
    Jonathan L Brigman; Fiscal Year: 2013
    ..with transgenic and mutant mouse models and gained experience in stereotaxic surgical procedures and histological techniques. During my fellowship at NIAAA under the mentorship of Dr...
  12. Mechanisms and Roles of Ca2+ Dysregulation in Alzheimer's Disease
    Dustin J Shilling; Fiscal Year: 2012
    ..Biochemical and histological techniques will be used to quantify AD lesion development...
  13. Atlas-Based Structural Models of the Mouse Myocardium
    Edward W Hsu; Fiscal Year: 2012
    ..models are methodologically hampered by the labor-intensive and destructive nature of conventional histological techniques. More importantly, since previous models were constructed from limited numbers of specimens, the degree ..
  14. MULTIPARAMETRIC MRI OF CARTILAGE
    Deborah Burstein; Fiscal Year: 2009
    ....
  15. Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
    S ALI FATEMI; Fiscal Year: 2013
    ..program will include coursework and informal training in animal research, including advanced MRI and histological techniques, as well as cell culture and cell engineering methods...
  16. Structural Basis of Ventricular Function
    Xin Yu; Fiscal Year: 2010
    ..The standard histological techniques are destructive and labor intensive...
  17. How do photoreceptor axons choose appropriate post-synaptic partners?
    THOMAS ROBERT CLANDININ; Fiscal Year: 2010
    ..The visual system of Drosophila provides a unique context in which to use genetic, molecular genetic and histological techniques to define these mechanisms...
  18. MR Monitoring of Engineered Tissues
    Richard L Magin; Fiscal Year: 2012
    ..directly correlated with the underlying tissue composition and structure as measured by biochemical and histological techniques. Our long term goal is to extend these methods to assess the structure and function of developing, ..
  19. Hyaluronan-mediated regulation of Langerhans cells
    Mark Mummert; Fiscal Year: 2009
    ..most efficacious treatment for cutaneous BCCs, SCCs and MMs is surgical excisions of tumors coupled with histological techniques to demarcate the tumor margins. However, histology for demarcation of tumor margins can be ambiguous...
  20. Dynamic Biochemical Tissue Analysis: A Novel In Situ Assay
    MONICA BURDICK; Fiscal Year: 2011
    ..Some of the most powerful histological techniques are those that characterize the biochemistry of tissue sections...
  21. ALL-OPTICAL HIGH-THROUGHPUT FUNCTIONAL CONNECTIVITY MAPPING USING ADVANCED MICROS
    Peter Saggau; Fiscal Year: 2013
    ..High-resolution connectomes are presently established by advanced histological techniques, involving serial sectioning and electron microscopy, however, this approach primarily produces ..
  22. Muscarinic Acetylcholine Receptors and Alzheimer's Disease Pathogenesis
    ALBERT DAVIS; Fiscal Year: 2009
    ..By investigating the relationship of muscarinic acetylcholine receptors to the underlying cause of AD, this study seeks to increase the molecular understanding and potential therapeutic avenues of this devastating illness. ..
  23. Dystonia in an Animal Model of Kernicterus
    Steven Shapiro; Fiscal Year: 2007
    ..We will use standard histological techniques of injury and cell death including TUNEL and caspase 3 staining for apoptosis, and unbiased stereology to ..
  24. Estrogen Withdrawal and Dural Mast Cells: Implication for Menstrual Migraine
    Dan Levy; Fiscal Year: 2010
    ..to test our working hypotheses using in-vivo electrophysiological recordings as well as behavioral and histological techniques. Three specific aims are proposed: Aim 1 is to determine whether estrogen withdrawal, either occurring ..
  25. Role of SLc11a1 Gen in Warm Ischemia-Reperfusion Injury
    Samuel Wyllie; Fiscal Year: 2006
    ..Standard biochemical and histological techniques will be employed to evaluate blood transaminases and H&E liver sections, in conjunction with ..
  26. A comparative study of visual cortex in diurnal and nocturnal rodents.
    KATHARINE CAMPI; Fiscal Year: 2009
    ..To achieve the goals of this proposal we will combine electrophysiological recordings, histological techniques, and neuroantomical data to make direct comparisons between the size, functional organization, ..
  27. HUMAN MODEL OF VESTIBULAR DEAFFERENTATION
    Akira Ishiyama; Fiscal Year: 2001
    ..A combination of classical histological techniques, immunohistochemistry, electron microscopy, molecular biologic techniques, and computer based ..
  28. FIBROCARTILAGINOUS KNEE JOINT MENISCI: BIOLOGY & REPAIR
    Richard Webber; Fiscal Year: 1991
    ..achieve these goals the following methodologies will be used: (1) cell and organ culture techniques; (2) histological techniques to include light and electron microscopy; (3) conventional and high-pressure liquid chromatography; (4) ..
  29. Smart Substrates for a New Generation of Implants
    Irving Shapiro; Fiscal Year: 2009
    ..Following twelve weeks of recovery, femora will be recovered and analyzed using physical, optical, and histological techniques. Outcomes from this study will provide information for engineering of orthopaedic and dental implants ..
  30. Nanoparticles and Arterial Disease
    VIRGINIA MILLER; Fiscal Year: 2009
    ..In addition to standard histological techniques, state-of-the-art, cryostatic microcomputed tomography will be used that offers the unique advantage of ..
  31. IN VITRO & IN VIVO MODEL OF MENISCAL WOUND REPAIR
    Richard Webber; Fiscal Year: 1990
    ..achieve these goals, the following methodologies will be used: (1) cell and organ culture techniques; (2) histological techniques, to include light and electron microscopy; (3) conventional and high-pressure liquid chromatography; (4) ..
  32. Alzheimre's disease antiamyloid neuroprotective tmt
    Bala Manyam; Fiscal Year: 2003
    ..and deposition of Abeta 40 and 42 isoforms using ELISA as well as antibodies to Abeta and standard histological techniques known to detect fibrillar amyloid at each of the three age groups tested...
  33. REGENERATION OF THE EIGHTH CRANIAL NERVE
    ANITA NEWMAN; Fiscal Year: 1992
    ..A combination of classical histological techniques and the newest histochemical methods for studying the trajectory of nerve fibers, and computer based ..
  34. FETAL ALCOHOL EXPOSURE AND NMDA RECEPTOR INTERACTION
    ANDREA ELBERGER; Fiscal Year: 2001
    ..Using the same histological techniques, a transgenic strain of mouse with total (-/-) deletion of the NMDA-R1 receptor has also been shown to ..
  35. Polymers with time-dependent properties for drug deliver
    Brent Vernon; Fiscal Year: 2007
    ..In vivo compatibility will be assessed using selected histological techniques. In vivo efficacy of phenstatin released from this material will be evaluated using a SCID mouse ovarian ..
  36. ETB IN REGULATION OF RENAL SODIUM HANDLING
    CHERYL GARIEPY; Fiscal Year: 2003
    ..They will use a variety of biochemical and histological techniques to examine the expression of ETB and its ligands, ET1 and ET3, in the normal kidney during high and low ..
  37. Magnetic Resonance Study of Chemotherapy-induced Liver Toxicity
    KRISTEN ZAKIAN; Fiscal Year: 2009
    ..The second aim is to assess chemotherapy-induced liver abnormalities by histological techniques. The third aim is to test whether treatment-related MR parameter changes are correlated with histological ..
  38. MICROVASCULAR DIMENSIONS AND GAS EXCHANGE
    GARY MALVIN; Fiscal Year: 1992
    ..The thickness of the blood-air diffusion barrier will be measured using standard histological techniques. Different amphibians with a variety of epidermal thickness will be tested and compared...
  39. MOLECULAR CHANGES IN DIFFERENTIATING DENTAL MESENCHYME
    Irma Thesleff; Fiscal Year: 1992
    ..These cultures will be analysed by various histological techniques as well as in situ hybridization...
  40. AIDS--ASSOCIATED HEART DISEASE IN ADULTS
    AZORIDES MORALES; Fiscal Year: 1990
    ..Also, the potential use of endomyocardial biopsy for specific diagnosis will be explored...
  41. Histopathology and Electroretinography Services
    Richard Smith; Fiscal Year: 2007
    ..The Jackson Laboratory (TJL) eye investigators use diverse sophisticated histological techniques to obtain accurate, informative data on eye morphology and histopathology...
  42. MPTP AND AGING--MOLECULAR/MORPHOLOGICAL CORRELATES
    J Langston; Fiscal Year: 1990
    ..In addition, standard histological techniques will be employed to assess the morphological features of MPTP in aged rodents.
  43. IN SITU FUNCTIONAL MORPHOMETRY OF INTERVERTEBRAL DISC
    Edward Hsu; Fiscal Year: 2001
    ..correlation of the collagen fiber structure determined by MR diffusion tensor microscopy and established histological techniques in excised AF samples...
  44. Photoreceptor specification in the Drosophila eye
    Andrew Tomlinson; Fiscal Year: 2013
    ..pathways specify a number of distinct cell types, and we aim to use a variety of molecular, genetic and histological techniques to understand how the two signaling pathways are integrated and interpreted in the cells, and how this ..
  45. AUTORADIOGRAPHY OF CARDIAC ISCHEMIA
    Jesus Bianco; Fiscal Year: 1993
    ..myocardial sections using histochemical techniques for early evidence of necrosis (TTC stain) and histological techniques for delayed evidence of necrosis (light microscopy)...
  46. ER:YAG LASER LENS EMULSIFICATION
    COLETTE COZEAN; Fiscal Year: 1992
    ..acoustic effect in lens emulsification, to establish the optimal laser dosimetry, to evaluate through histological techniques the presence or lack thereof of adverse effects to adjacent structures in the eye, and to design a ..
  47. PNEUMOCYTE-IMMUNE CELL INTERACTIONS IN THE DISTAL LUNG
    DAVID PHELPS; Fiscal Year: 1993
    ..II cells and in lung tissue from normal and glucocorticoid-immunosuppressed rats using biochemical and histological techniques. Reciprocal regulatory influences between immune cells in the alveolus and the type II cell and its ..
  48. Nanoparticle Targeting to Control Angiogenesis
    JEFFREY DAVIDSON; Fiscal Year: 2006
    ..In addition, conventional morphometric and histological techniques will be used to quantify the efficacy of this novel drug delivery system...
  49. IN VIVO ANALYSIS OF CADHERINS IN EPIDERMAL DEVELOPMENT
    MICHELLE HINES; Fiscal Year: 2001
    ..A combination of biochemical, molecular and histological techniques will be used to characterize the phenotype of the epidermis expressing the dominant negative cadherin...
  50. NEURONAL CYTOSKELTON IN CULTURAL MODEL OF INJURY-REPAIR
    Mark Gilbert; Fiscal Year: 1993
    ..This will facilitate the long term goals of permitting rational development of pharmacological approaches to preventing or reversing neurotoxicity...
  51. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..To test our hypothesis, we will employ biochemical and histological techniques together with an HPLC-analyzed preparation of PC-SPES to systematically address the following specific ..
  52. Nonlinear Intrinsic Microspectroscopy of Cancer
    Warren Zipfel; Fiscal Year: 2004
    ..aims are: 1) A direct comparison of multiphoton imaging of intrinsic tissue signals with standard histological techniques, focusing on the discovery of new diagnostic criteria...
  53. TENDON TO BONE HEALING--ROLE OF MECHANICAL ENVIRONMENT
    Gerald Williams; Fiscal Year: 2003
    ..Our global hypothesis is that in vivo mechanical factors (exercise vs. cage activity vs. immobilization) will cause a change in the mechanical properties, composition, and organization of the healing insertion site. ..
  54. Role of Heparin Sulfate in Neuregulin Signaling during Development and in Disease
    MARK PANKONIN; Fiscal Year: 2007
    ..Magnetic resonance spectroscopy (MRS), and imaging (MRI), as well as various histological techniques will be utilized to identify the critical domains of this protein that mediate its axon maintaining ..
  55. TARGETED KNOCKOUT OF PKD1 GENE IN RENAL COLLECTING DUCT
    Raoul Nelson; Fiscal Year: 2000
    ..used to identify mutant PKD1 mRNA, loss of polycstin expression demonstrated by immunohistochemistry, and histological techniques employed to analyze cyst formation...
  56. BRAIN THERAPY USING ULTRASOUND MEDIATED DRUG DELIVERY
    Lawrence Ng; Fiscal Year: 2001
    ..protein, (b) studying the morphological and cytological characteristics of BBB cells using standard histological techniques, and (c) determining the BBB cell viability, as a function of various ultrasound parameters; (4) ..
  57. Quantitative Assessment of Murine Tumors with MicroPET.
    Craig Abbey; Fiscal Year: 2004
    ..However, standard histological techniques for assessing are labor intensive and invasive, and therefore limit the use of mouse models for finding ..
  58. Multiphoton Detection of Cancer
    Warren Zipfel; Fiscal Year: 2009
    ..comparison of multiphoton imaging and spectroscopic parameters of intrinsic tissue signals with standard histological techniques, focusing on the discovery of new diagnostic criteria for cancer...
  59. Controlling Apoptosis in Oligondendrocytes
    Pamela Knapp; Fiscal Year: 2005
    ..Specific Aim 4: Biochemical and histological techniques are used to determine whether pathways which are independent of caspase-3 play a significant role in cell ..
  60. The Function of NKT Cells During T Cruzi Infection
    Stuart Kahn; Fiscal Year: 2004
    ..with wild type NKT cells or NKT cells lacking effector functions using cellular immunological and histological techniques. Completion of these aims will provide important insights into NKT cell functions during protective and ..
  61. OSSEOUS HEALING IN RIDGE AUGMENTATION PROCEDURES
    Raymond Fonseca; Fiscal Year: 1980
    ..Mandibular ridge augmentation procedures will be performed on edentulous monkeys. The fate of the bone grafts will be studied using clinical radiographic, microangiographic, and histologic techniques...
  62. Neuropathology and Pathogenesis of Huntington's Disease
    Anton Reiner; Fiscal Year: 2008
    ..abstract_text> ..