cell count

Summary

Summary: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.

Top Publications

  1. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
  2. ncbi Neurogenesis in the adult is involved in the formation of trace memories
    T J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 410:372-6. 2001
  3. pmc Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    Fabrizio Thorel
    Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Nature 464:1149-54. 2010
  4. ncbi Notch signalling regulates stem cell numbers in vitro and in vivo
    Andreas Androutsellis-Theotokis
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 442:823-6. 2006
  5. ncbi Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    Anjen Chenn
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 297:365-9. 2002
  6. doi Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas
    Francisco M Nadal-Nicolás
    Departamento de Oftalmologia, Facultad de Medicina, Universidad de Murcia, Murcia, Spain
    Invest Ophthalmol Vis Sci 50:3860-8. 2009
  7. ncbi Doublecortin expression levels in adult brain reflect neurogenesis
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 21:1-14. 2005
  8. ncbi Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    Ichiro Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Stem Cells 20:530-41. 2002
  9. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
  10. ncbi CellProfiler: free, versatile software for automated biological image analysis
    Michael R Lamprecht
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Biotechniques 42:71-5. 2007

Detail Information

Publications377 found, 100 shown here

  1. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    ..Under conditions of stress, restricted cell cycling is crucial to prevent premature stem cell depletion and hematopoietic death...
  2. ncbi Neurogenesis in the adult is involved in the formation of trace memories
    T J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 410:372-6. 2001
    ..These results indicate that newly generated neurons in the adult are not only affected by the formation of a hippocampal-dependent memory, but also participate in it...
  3. pmc Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    Fabrizio Thorel
    Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Nature 464:1149-54. 2010
    ..Such inter-endocrine spontaneous adult cell conversion could be harnessed towards methods of producing beta-cells for diabetes therapies, either in differentiation settings in vitro or in induced regeneration...
  4. ncbi Notch signalling regulates stem cell numbers in vitro and in vivo
    Andreas Androutsellis-Theotokis
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 442:823-6. 2006
    ..These data indicate that stem cell expansion in vitro and in vivo, two central goals of regenerative medicine, may be achieved by Notch ligands through a pathway that is fundamental to development and cancer...
  5. ncbi Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    Anjen Chenn
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 297:365-9. 2002
    ....
  6. doi Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas
    Francisco M Nadal-Nicolás
    Departamento de Oftalmologia, Facultad de Medicina, Universidad de Murcia, Murcia, Spain
    Invest Ophthalmol Vis Sci 50:3860-8. 2009
    ..To characterize Brn3a expression in adult albino rat retinal ganglion cells (RGCs) in naïve animals and in animals subjected to complete intraorbital optic nerve transection (IONT) or crush (IONC)...
  7. ncbi Doublecortin expression levels in adult brain reflect neurogenesis
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 21:1-14. 2005
    ....
  8. ncbi Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    Ichiro Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Stem Cells 20:530-41. 2002
    ..The results indicate that, when preparing cultures of human MSCs, it is necessary to compromise between conditions that provide the highest overall yields and those that provide the highest content of early progenitor cells...
  9. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
    ..We propose that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size...
  10. ncbi CellProfiler: free, versatile software for automated biological image analysis
    Michael R Lamprecht
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Biotechniques 42:71-5. 2007
    ....
  11. doi Progesterone induces adult mammary stem cell expansion
    Purna A Joshi
    Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada
    Nature 465:803-7. 2010
    ..Our findings uncover a dynamic role for progesterone in activating adult MaSCs within the mammary stem cell niche during the reproductive cycle, where MaSCs are putative targets for cell transformation events leading to breast cancer...
  12. pmc KLF family members regulate intrinsic axon regeneration ability
    Darcie L Moore
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Science 326:298-301. 2009
    ..Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons...
  13. ncbi GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells
    Yusuke Tozuka
    Department of Integrated Biosciences, University of Tokyo, Kashiwa 277 8562, Japan
    Neuron 47:803-15. 2005
    ..Thus, it appears that GABAergic inputs to hippocampal progenitor cells promote activity-dependent neuronal differentiation...
  14. ncbi Tumor-associated macrophages: the double-edged sword in cancer progression
    Jeremy J W Chen
    Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan, People s Republic of China
    J Clin Oncol 23:953-64. 2005
    ..Inflammation plays a critical role in cancer progression. In this study we investigate the pro-tumorigenic activities and gene expression profiles of lung cancer cells after interaction with macrophages...
  15. ncbi A systematic review of tests predicting ovarian reserve and IVF outcome
    F J Broekmans
    Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:685-718. 2006
    ..As poor ovarian response will provide some information on OR status, especially if the stimulation is maximal, entering the first cycle of IVF without any prior testing seems to be the preferable strategy...
  16. ncbi Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Psychiatr Res 42:151-7. 2008
    ..Therefore, the hypothesis of microglial activation during acute psychosis was proposed. Alternatively, "suicide" could be a diagnosis-independent factor leading to microgliosis...
  17. ncbi Neocortical neuron number in humans: effect of sex and age
    B Pakkenberg
    Neurological Research Laboratory, Bartholin Instituttet, Kommunehospitalet, Copenhagen K, Denmark
    J Comp Neurol 384:312-20. 1997
    ..Some of the data presented have been analyzed by using new mathematical designs. An equation predicting the total neocortical neuron number in any individual in which sex and age are known is provided...
  18. ncbi Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain
    Suzana Herculano-Houzel
    Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941 590
    J Neurosci 25:2518-21. 2005
    ..Moreover, contrary to what is commonly assumed in the literature, we show that glial cells are not the majority in the rat brain...
  19. doi Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma
    Brian P Buckingham
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 28:2735-44. 2008
    ..This progression of degeneration suggests a need to examine the RGC axon as a locus of pathology in glaucoma...
  20. pmc p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
    Tod E Kippin
    Neurobiology Research Group, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 19:756-67. 2005
    ..Thus, p21 contributes to adult NSC relative quiescence, which we propose is necessary for the life-long maintenance of NSC self-renewal because NSCs may be limited to a finite number of divisions...
  21. ncbi Design-based stereology in neuroscience
    C Schmitz
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, University of Maastricht, P O Box 616, NL 6200 MD Maastricht, Netherlands
    Neuroscience 130:813-31. 2005
    ..These characteristics establish the advantages of design-based stereologic methods in quantitative neuromorphology...
  22. ncbi Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations
    L Jayaram
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
    Eur Respir J 27:483-94. 2006
    ..It had no influence on the frequency of noneosinophilic exacerbations, which were the most common exacerbations...
  23. ncbi Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    Yuval Dor
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 429:41-6. 2004
    ..These results suggest that terminally differentiated beta-cells retain a significant proliferative capacity in vivo and cast doubt on the idea that adult stem cells have a significant role in beta-cell replenishment...
  24. pmc Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
    Tatjana C Jakobs
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114
    J Cell Biol 171:313-25. 2005
    ..However, the architecture of the mouse eye seems to preclude a commonly postulated source of mechanical damage within the nerve head...
  25. ncbi Descemet-stripping automated endothelial keratoplasty
    Mark S Gorovoy
    Cornea 25:886-9. 2006
    ..To evaluate the speed of visual recovery in 16 consecutive patients with corneal endothelial dysfunction who received Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  26. ncbi Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat
    Masafumi Kodama
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 56:570-80. 2004
    ..There has been increasing evidence that atypical antipsychotics are effective in the treatment of mood disorders or for augmenting 5-hydroxytryptamine selective reuptake inhibitors for treatment-resistant depression...
  27. ncbi Size control in animal development
    I Conlon
    Developmental Neurobiology Programme, Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
    Cell 96:235-44. 1999
  28. ncbi Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  29. pmc Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma
    Thomas V Johnson
    Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Invest Ophthalmol Vis Sci 51:2051-9. 2010
    ..Local, but not systemic, transplantation of MSCs was neuroprotective in a rat glaucoma model. Autologous intravitreal transplantation of MSCs should be investigated further as a potential neuroprotective therapy for glaucoma...
  30. ncbi Müller cell response to laser-induced increase in intraocular pressure in rats
    Elizabeth WoldeMussie
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612, USA
    Glia 47:109-19. 2004
    ..The increase in GLAST along with minimum change in GS indicates a disturbance in glutamate homeostasis...
  31. ncbi Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes
    Rachel A Feit-Leichman
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:4281-7. 2005
    ..The objective of this study was to characterize the occurrence and pathologic progression of diabetic retinopathy in C57Bl/6J mice...
  32. ncbi Proliferative response of corneal endothelial cells from young and older donors
    Cheng Zhu
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1743-51. 2004
    ....
  33. pmc Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk
    I Jialal
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Atherosclerosis 211:297-302. 2010
    ..We aimed to enumerate and functionally characterize EPCs in subjects with MetS in comparison to healthy controls...
  34. ncbi Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach
    C Schmitz
    Department of Anatomy and Cell Biology, RWTH University of Aachen, Pauwelsstrasse Wendlingweg 2, 52057, Aachen, Germany
    J Chem Neuroanat 20:93-114. 2000
    ..In particular, we strongly recommend counting considerably more neurons than is currently done in the literature when estimating total neuronal numbers using design-based stereology...
  35. ncbi Uremia causes endothelial progenitor cell deficiency
    Kirsten de Groot
    Division of Nephrology, Department of Internal Medicine Hannover Medical School, Hannover, Germany
    Kidney Int 66:641-6. 2004
    ..Their number in peripheral blood correlates with endothelial function and cardiovascular risk in humans. We explored whether uremia influences the number of EPCs...
  36. doi A computerized analysis of the entire retinal ganglion cell population and its spatial distribution in adult rats
    M Salinas-Navarro
    Laboratorio de Oftalmologia Experimental, Facultad de Medicina, Universidad de Murcia, E 30100 Murcia, Spain
    Vision Res 49:115-26. 2009
    ..Detailed methodology to provide cell density information at small scales demonstrated the presence of a horizontal region in the dorsal retina with highest densities, resembling a visual streak...
  37. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
  38. pmc De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance
    Andrew A Pierce
    Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:723-30. 2010
    ..It further suggests that de novo neurogenesis might serve as a compensatory mechanism contributing to the plastic control of energy balance in response to environmental and physiologic insults...
  39. ncbi Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk-1 protein expression
    Vivi M Heine
    Institute Neurobiology, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 21:1304-14. 2005
    ..This demonstrates that changes in angiogenic factors are implicated in the decreased adult proliferation found after chronic stress...
  40. pmc Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice
    Koji Ohira
    Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Mol Brain 4:10. 2011
    ..Since almost all of those studies treated animals with drugs for 2 to 4 weeks as chronic treatment models of antidepressants, it is possible that antidepressant treatments for longer periods would affect adult neurogenesis in the SVZ...
  41. pmc The Tlx gene regulates the timing of neurogenesis in the cortex
    Kristine Roy
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:8333-45. 2004
    ..These studies indicate that tlx is an essential intrinsic regulator in the decision to proliferate or differentiate in the developing forebrain...
  42. doi Adult hippocampal neurogenesis is involved in anxiety-related behaviors
    J M Revest
    INSERM U862, Neurocenter Magendie, Pathophysiology of Addiction group, Bordeaux, France
    Mol Psychiatry 14:959-67. 2009
    ..Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders...
  43. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
    ....
  44. doi Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
    P Nair
    Firestone Institute for Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 42:1097-103. 2012
    ..It is not clear if they contribute to the lack of control and severity. There are currently no strategies to investigate this by decreasing neutrophil numbers in the airways...
  45. pmc Structural uniformity of neocortex, revisited
    C Nikoosh Carlo
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:1488-93. 2013
    ..In addition, we have observed that the number of glial cells under a square millimeter of cortical surface depends on cortical thickness, but not on cortical area or species...
  46. ncbi Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer
    Maya Gulubova
    Department of General and Clinical Pathology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
    J Gastroenterol Hepatol 24:1265-75. 2009
    ....
  47. pmc A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas
    F Farace
    Translational Research Laboratory, Institut de Cancerologie Gustave Roussy, 94805 Villejuif, France
    Br J Cancer 105:847-53. 2011
    ..However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on cell size (ISET assay)...
  48. doi Control of mammary stem cell function by steroid hormone signalling
    Marie Liesse Asselin-Labat
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 465:798-802. 2010
    ..These findings further indicate that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function...
  49. pmc Neuregulin-1 type III determines the ensheathment fate of axons
    Carla Taveggia
    Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:681-94. 2005
    ..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons...
  50. ncbi Circulating endothelial progenitor cells and cardiovascular outcomes
    Nikos Werner
    Division of Cardiology, Angiology, and Intensive Care Medicine, Department of Internal Medicine, University of Saarland, Homburg Saar, Germany
    N Engl J Med 353:999-1007. 2005
    ..The number and function of endothelial progenitor cells correlate inversely with cardiovascular risk factors, but the prognostic value associated with circulating endothelial progenitor cells has not been defined...
  51. pmc The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus
    G O Elpek
    Department of Pathology, Akdeniz University, Medical School, Dekanlik, 07070 Antalya, Turkey
    J Clin Pathol 54:940-4. 2001
    ..The aim of this study was to investigate the prognostic value of MVD and MCD in SCC of the oesophagus. The correlation between MVD and MCD was also evaluated...
  52. ncbi Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer
    Giovanna Vona
    Pasteur INSERM Unit 370, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75739 Paris cedex 15, France
    Hepatology 39:792-7. 2004
    ..We also show the feasibility of molecular studies of individual circulating tumor cells, aimed at identifying gene mutations involved in tumor invasion...
  53. pmc Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis
    Ramón Guirado
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Dpt, Universitat de Valencia, Spain
    BMC Neurosci 13:5. 2012
    ..PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents...
  54. doi Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects
    So Ueda
    Department of Internal Medicine, Division of Cardio Vascular Medicine, Kurume, Japan
    Cardiovasc Ther 30:249-54. 2012
    ..Therefore, in this study, we investigated whether serum level of AGEs was associated with EPC number and functions in apparently healthy subjects, independent of traditional cardiovascular risk factors...
  55. doi A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
    Bunmi Ojo
    Department of Life Sciences, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
    Exp Neurol 232:318-28. 2011
    ..These results demonstrate that FGL can indeed regulate neuroglial activation and reduce microglial cell density in the aged hippocampus, and support its potential use as a therapeutic agent in age-related brain disorders...
  56. doi Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway
    Jared M Campbell
    Centre for Stem Cell Research, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia
    Stem Cells Dev 21:2430-41. 2012
    ..Furthermore, we suggest that the inclusion of insulin in culture media could be used as a strategy for increasing the efficiency with which the ESC lines can be derived from cultured embryos...
  57. pmc Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice
    Marie Chintinne
    Diabetes Research Center, Brussels Free University VUB, and Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
    PLoS ONE 7:e43959. 2012
    ..This study examines whether PDL increases beta cell number and whether this is caused by neogenesis of small clusters and/or their growth to larger aggregates...
  58. ncbi Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats
    Jyotirmoy Kusari
    Department of Biological Sciences, Allergan Inc, Irvine, CA 92623 9534, USA
    Invest Ophthalmol Vis Sci 48:5152-9. 2007
    ..To test whether chronic memantine (MEM) treatment improves retinal function and prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ)-induced diabetic rats...
  59. doi Circulating melanoma cells and survival in metastatic melanoma
    C Rao
    Veridex LLC, Huntingdon Valley, PA, USA
    Int J Oncol 38:755-60. 2011
    ..Patients with ≥2 CMCs per 7.5 ml of whole blood, as compared with the group with <2 CMCs, had a shorter overall survival (2.0 months vs. 12.1 months, P=0.001)...
  60. doi Invited review: effect of udder health management practices on herd somatic cell count
    S Dufour
    Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal, C P 5000, St Hyacinthe, Quebec, J2S 7C6, Canada
    J Dairy Sci 94:563-79. 2011
    ..of the scientific literature on relationships between management practices used on dairy farms and herd somatic cell count (SCC) was undertaken to distinguish those management practices that have been consistently shown to be ..
  61. ncbi Microglial cell population dynamics in the injured adult central nervous system
    Rune Ladeby
    Medical Biotechnology Center, University of Southern Denmark, Odense C
    Brain Res Brain Res Rev 48:196-206. 2005
    ....
  62. doi The usefulness of biomarkers of airway inflammation in managing asthma
    Sarita U Patil
    Divsion of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Allergy Asthma Proc 31:259-68. 2010
    ..Combined approaches using simple methods of measuring airway hyperreactivity and obtaining sputum samples hold promise for the future, particularly if rapid analysis of cellular products in sputum can be developed...
  63. pmc Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice
    Harry A Quigley
    Glaucoma Research Laboratory, Wilmer Eye Institute, 600 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9205, USA
    Exp Eye Res 92:299-305. 2011
    ..Counts of RGC layer cells and optic nerve axons indicate that Jnk3(-/-) mice have an increased number of amacrine cells compared to WT controls...
  64. pmc P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    J Neuroinflammation 7:65. 2010
    ..In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models...
  65. pmc High-throughput selection, enumeration, electrokinetic manipulation, and molecular profiling of low-abundance circulating tumor cells using a microfluidic system
    Udara Dharmasiri
    Center for Bio Modular Multi Scale Systems, Louisiana State University, 8000 GSRI Road, Building 3100, Baton Rouge, Louisiana 70820 7403, United States
    Anal Chem 83:2301-9. 2011
    ..However, the HT29 cells did not contain these mutations, consistent with their known genotype...
  66. doi Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus)
    Michael W Marlatt
    Swammerdam Institute for Life Science Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Exp Neurol 230:291-301. 2011
    ....
  67. pmc FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools
    Nick J Van Hateren
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, S10 2TN, UK
    Development 138:1893-902. 2011
    ....
  68. doi Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors
    Suzanne Hood
    Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Neurosci 30:14046-58. 2010
    ..These observations may have implications for circadian abnormalities seen in Parkinson's disease...
  69. doi Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats
    Henry A Nasrallah
    Dept of Psychiatry, Univ of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Brain Res 1354:23-9. 2010
    ..This olfactory model can be employed in human research as a method to explore the neurogenesis effects of various pharmacologic treatments of neuropsychiatric disorders...
  70. pmc The onset of collective behavior in social amoebae
    Thomas Gregor
    Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153 8902, Japan
    Science 328:1021-5. 2010
    ..A quantitative analysis showed that stochastic pulsing of individual cells below the threshold concentration of extracellular cAMP plays a critical role in the onset of collective behavior...
  71. doi Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion
    A C R Beitnes
    Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand J Immunol 74:186-94. 2011
    ....
  72. ncbi Initial results of endothelial cell counts after Artisan lens for phakic eyes: an evaluation of the United States Food and Drug Administration Ophtec Study
    Mihai Pop
    Michel Pop Clinics, Montreal, Canada
    Ophthalmology 111:309-17. 2004
    To evaluate the endothelial cell count change in eyes implanted with the iris-claw phakic Artisan lens for treatment of moderate to high myopia.
  73. ncbi Glial reactivity, an early feature of diabetic retinopathy
    E Rungger-Brandle
    Cell Biology Laboratory, University Eye Clinic, Geneva, Switzerland
    Invest Ophthalmol Vis Sci 41:1971-80. 2000
    ..To characterize early structural gliotic reactions in retinal Müller cells, astrocytes, and microglia in experimentally induced diabetes...
  74. doi Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals
    Sven Mobius-Winkler
    Universität Leipzig Herzzentrum, Klinik fur Kardiologie, Leipzig, Germany
    J Appl Physiol (1985) 107:1943-50. 2009
    ..All observed changes were normalized 24 h after finishing the test. In conclusion, strenuous activity in healthy individuals leads to a time-dependent increase in mECs, PCs, and EPCs that may be related to VEGF and IL-6...
  75. ncbi Apoptosis and cell proliferation potential of bovine embryos stimulated with insulin-like growth factor I during in vitro maturation and culture
    A V Makarevich
    Agrifood Research Finland, Animal Production Research, FIN 31600 Jokioinen, Finland
    Biol Reprod 66:386-92. 2002
    ..Our data suggest that an assay for TUNEL in conjunction with cell proliferation analysis can provide useful information about the quality of IVP embryos...
  76. ncbi Unilateral optic nerve crush induces bilateral retinal glial cell proliferation
    L Panagis
    Laboratory of Physiology and Neurobiology, Department of Biology, University of Crete, 71409 Heraklion, Crete, Greece
    Eur J Neurosci 21:2305-9. 2005
    ..The acute glial responses observed suggest that bilateral glial proliferation might represent a common response related to degeneration events in both retinas, i.e. ipsi- and contralateral to the experimental injury...
  77. ncbi The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity
    S P Crouch
    Medical Research Centre, City Hospital, Nottingham, UK
    J Immunol Methods 160:81-8. 1993
    ..It would therefore appear to be possible to use ATP bioluminescence in the detection of cytokine activity in a number of different bioassays...
  78. doi Challenges in the enumeration and phenotyping of CTC
    Frank A W Coumans
    Department of Medical Cell Biophysics, MIRA Institute, University of Twente, Enschede, The Netherlands
    Clin Cancer Res 18:5711-8. 2012
    ..Phenotyping and genotyping of CTC may permit "real-time" treatment decisions, provided CTCs are available for examination. Here, we investigate what is needed to detect CTC in all patients...
  79. doi Comparative visual function in elasmobranchs: spatial arrangement and ecological correlates of photoreceptor and ganglion cell distributions
    Lenore Litherland
    Sensory Neurobiology Group, School of Biomedical Science, The University of Queensland, Brisbane, Australia
    Vis Neurosci 25:549-61. 2008
    ..Species-specific retinal specializations strongly correlate to the habitat and feeding behavior of each species...
  80. ncbi 1H MRS-visible lipids accumulate during apoptosis of lymphoma cells in vitro and in vivo
    Jonathan E Schmitz
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Magn Reson Med 54:43-50. 2005
    ..This study confirms that MRS-detectable lipids accumulate in tumor cells undergoing apoptosis, and therefore may be usable as a marker for the noninvasive detection of tumor cell apoptosis in the clinic...
  81. ncbi Astrocytes are a specific immunological target in Rasmussen's encephalitis
    Jan Bauer
    Division of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Ann Neurol 62:67-80. 2007
    ..An in vitro study, however, suggested glutamate receptor 3 (GluR3) antibody-mediated astrocytic loss. Therefore, we investigated astrocytic apoptosis and loss in situ...
  82. ncbi The morphological association between microcracks and osteocyte lacunae in human cortical bone
    Shijing Qiu
    Bone and Mineral Research Laboratory, E and R Building 7071, Henry Ford Hospital, 2799 W Grand Boulevard, Detroit, MI 48202, USA
    Bone 37:10-5. 2005
    ..We conclude that microdamage and osteocyte deficiency occur in the same bone regions; there is likely a causal relationship between them but we are unable to say which comes first...
  83. ncbi The activation of prefrontal cortical neurons in aggression--a double labeling study
    Jozsef Halasz
    Department of Behavioral Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary
    Behav Brain Res 175:166-75. 2006
    ..Based on these data, we present a tentative hypothesis on the involvement of the prefrontal cortex in the control of aggression...
  84. ncbi United States Food and Drug Administration clinical trial of the Implantable Collamer Lens (ICL) for moderate to high myopia: three-year follow-up
    Donald R Sanders
    Center for Clinical Research, Chicago, Illinois, USA
    Ophthalmology 111:1683-92. 2004
    ..To report on 3-year postoperative safety and efficacy outcomes with the Myopic Implantable Collamer Lens (ICL)...
  85. pmc Mast cell repopulation of the peritoneal cavity: contribution of mast cell progenitors versus bone marrow derived committed mast cell precursors
    Maria Celia Jamur
    Department of Cell and Molecular Biology and Pathogenic Bioagents, University of Sao Paulo, Ribeirao Preto, Brazil
    BMC Immunol 11:32. 2010
    ..This study was undertaken to determine the mast cell response in the peritoneal cavity and bone marrow during repopulation of the peritoneal cavity in rats...
  86. ncbi Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model
    Keith R G Martin
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 44:4357-65. 2003
    ....
  87. ncbi The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089 0191, USA
    FASEB J 16:814-24. 2002
    ....
  88. doi Cell cycle dynamics of NG2 cells in the postnatal and ageing brain
    Konstantina Psachoulia
    Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron Glia Biol 5:57-67. 2009
    ..We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age)...
  89. ncbi Resting and activated endothelial cells are increased in the peripheral blood of cancer patients
    P Mancuso
    Division of Hematology-Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Blood 97:3658-61. 2001
    ..Blood. 2001;97:3658-3661)..
  90. pmc Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
    J Zhang
    Department of Medicine, University of Toronto, Ontario, Canada M5G 1X5
    J Exp Med 190:1329-42. 1999
    ..The data also reveal a role for WASp in modulating endocytosis and phagocytosis and, accordingly, suggest that the immune deficit conferred by WASp deficiency reflects the disruption of a broad range of cellular behaviors...
  91. doi Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors
    Carol H Yan
    Department of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Neurosci 31:12413-25. 2011
    ..Together, our results demonstrate that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties...
  92. ncbi Bovine blastocyst development rate in vitro is influenced by selection of oocytes by brillant cresyl blue staining before IVM as indicator for glucose-6-phosphate dehydrogenase activity
    H Alm
    Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Theriogenology 63:2194-205. 2005
    ..In addition, G6PDH activity may be useful as a marker for oocyte quality in future studies on factors affecting developmental competence...
  93. doi Endothelial cell loss after Descemet's stripping endothelial keratoplasty in a large prospective series
    Mark A Terry
    Corneal Services, Devers Eye Institute, Portland, Oregon 97210, USA
    Ophthalmology 115:488-496.e3. 2008
    ..To report the donor endothelial cell loss in the first year after Descemet's stripping endothelial keratoplasty (DSEK) for the treatment of endothelial dysfunction...
  94. pmc Decreased lung carcinoma cell density on select polymer nanometer surface features for lung replacement therapies
    Lijuan Zhang
    Department of Chemistry, Brown University, Providence, RI 02912, USA
    Int J Nanomedicine 5:269-75. 2010
    ..In this manner, PLGA with specific nanometer surface features may inhibit lung cancer cell density which may provide an important biomaterial for the treatment of lung cancer (from drug delivery to regenerative medicine)...
  95. ncbi Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
    Christopher Heeschen
    Department of Internal Medicine IV and Hematology, University of Frankfurt, Germany
    Blood 102:1340-6. 2003
    ..Epo appears to physiologically regulate EPC mobilization in patients with ischemic heart disease. Thus, Epo serum levels may help in identifying patients with impaired EPC recruitment capacity...
  96. ncbi Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia
    R Tanaka
    Department of Neurology, Juntendo University School of Medicine, 2 1 1, Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Neuroscience 117:531-9. 2003
    ....
  97. doi Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis
    Pragathi Achanta
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Behav Neurosci 123:1036-45. 2009
    ....
  98. ncbi Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome
    Jung Ho Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 21:71-8. 2006
    ..Our aim was to determine whether a relationship exists between the number of mucosal mast cells in the gut and visceral hypersensitivity...
  99. ncbi Lost caps in histological counting methods
    J C Hedreen
    Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA
    Anat Rec 250:366-72. 1998
    ..e., small object fragments unnoticed or missing at the section surfaces, are an unavoidable issue...
  100. pmc Postnatal phenotype and localization of spinal cord V1 derived interneurons
    Francisco J Alvarez
    Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio 45435, USA
    J Comp Neurol 493:177-92. 2005
    ..In summary, V1 interneurons develop into ipsilaterally projecting, inhibitory interneurons that include Renshaw cells, Ia inhibitory interneurons, and other unidentified proprioceptive interneurons...
  101. ncbi Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity
    Luc Vallières
    Laboratoire d Endocrinologie Moléculaire, Centre de Recherche du Centre Hospitalier de l Universite Laval, Universite Laval, Quebec, Quebec, G1V 4G2, Canada
    J Neurosci 23:5197-207. 2003
    ..This continuous traffic of macrophages across the blood-brain barrier provides a vehicle to introduce therapeutic genes into the nervous system...

Research Grants78

  1. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..Hospital laboratories routinely perform Gram stain, glucose/protein levels, cell count, and bacterial culture (where media/reagents are available) on cerebrospinal fluid (CSF) obtained via lumbar ..
  2. Multi-Dimensional Successful Aging Among HIV-Infected Adults
    David J Moore; Fiscal Year: 2013
    ..allostatic load, and, among HIV+ individuals, indicators of HIV disease severity (plasma HIV viral load, CD4+ T-cell count, AIDS/nonAIDS)...
  3. HPV &Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2013
    ..Furthermore, beyond total CD4+ T-cell count, the nature of the immune deficits in HIV+ women which effect HPV are poorly understood...
  4. Corticosteroids for Children with Febrile Urinary Tract Infections
    Nader Shaikh; Fiscal Year: 2013
    ..coli papGIA2 allele) and the inflammatory response (procalcitonin, C-reactive protein, polymorphonuclear cell count, erythrocyte sedimentation rate, interleukin 6, interleukin 8, macrophage migration inhibitory factor, ..
  5. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..Laboratory measures include CD40 ligand, C-reactive protein, D-dimer, blood cell count and differential...
  6. Biomarkers of Obesity, Prostate Tissue Inflammation, and BPH Progression
    Jay H Fowke; Fiscal Year: 2013
    ..waist-hip ratio, % body fat from bioelectric impedance analysis) is associated with inflammatory leukocyte cell count and inflammation severity in prostate biopsy cores from 500 men without prostate cancer or prostatic ..
  7. The role of PI3K/Akt pathway in the pathogenesis and treatment of Krabbe disease
    TUBA FEHR; Fiscal Year: 2012
    ..I will compare treated vs. untreated mutants in terms of survival, engraftment of donor cells, globoid cell count, nerve conduction velocity and muscle strength...
  8. Properties of HIV-1 DNA/RNA Assays for Detecting HIV Infection in Infants
    Raji Balasubramanian; Fiscal Year: 2012
    ..antiretroviral treatment, HIV subtype, and mode of delivery;mother's age, HIV-1 viral load, and CD4 cell count;and infant's CD% and birth weight...
  9. The role of CD8+ T cells in response to EBV-induced infectious mononucleosis
    Oludare A Odumade; Fiscal Year: 2010
    ..Diagnostic blood smears show abnormal circulating cytotoxic T cells and an elevated white blood cell count. The link between cancer and Epstein Barr viral genes has been well studied but yet little is known about what ..
  10. SQ641, new drug candidate to treat NTM infections
    Venkata M Reddy; Fiscal Year: 2010
    ..with preexisting lung conditions, or disseminated disease in HIV infected individuals with low blood CD4+ T-cell count (MAC) or infection of the soft tissues following trauma-inducing hospital procedures or cosmetic surgery (MAB)...
  11. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    MOSTAFA GABER; Fiscal Year: 2009
    ..has potent vascular anti-inflammatory effects, promotes vascular recovery from injury, and increases white blood cell count, making it an excellent candidate as a potential agent that facilitate tissue recovery and wound repair...
  12. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    Duane D Miller; Fiscal Year: 2012
    ..has potent vascular anti-inflammatory effects, promotes vascular recovery from injury, and increases white blood cell count, making it an excellent candidate as a potential agent that facilitate tissue recovery and wound repair...
  13. Monocyte-Macrophage Dynamics in NeuroAIDS
    Jay Rappaport; Fiscal Year: 2013
    ..this subset appears to expand to a degree correlating with HIV/SIV plasma viral load, and inversely with CD4+ T cell count. Based on the phenotype of these cells, the immunosuppression observed in AIDS, together with new information ..
  14. NEUROPATHOLOGY OF CHRONIC MANGANESE EXPOSURE
    Brad A Racette; Fiscal Year: 2010
    ..We will also attempt to correlate sterologic cell count with tissue Mn deposition in each region of interest...
  15. Plasma miRNA Biomarkers of HIV/SIV CNS Disease
    Janice E Clements; Fiscal Year: 2013
    ..Plasma biomarkers developed for AIDS (viral load and CD4+ T cell count), were essential in developing treatment paradigms...
  16. Zinc for HIV Disease among Alcohol Users -An RCT in the Russia ARCH Cohort
    Jeffrey H Samet; Fiscal Year: 2013
    ..improve markers of mortality as measured by the VACS index;(2) slow HIV disease progression as measured by CD4 cell count;(3) improve markers of AMI risk as measured by the Reynolds risk score;and (4) lower levels of microbial ..
  17. Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
    Wally R Smith; Fiscal Year: 2013
    ..a clinical endpoint, or maximum dose;ED and hospital visits;mean corpuscular volume;total hemoglobin;white blood cell count;reticulocyte count;and quality of life...
  18. Immune Activation and Isoniazid Metabolism in HIV/TB
    Gregory P Bisson; Fiscal Year: 2013
    ..different durations of INH prophylaxis to prevent tuberculosis (TB) in patients infected with HIV, a CD4 cell count <200 cells/mm3 increased the risk of INH-associated hepatotoxicity over 4 fold...
  19. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE-ROWLAND; Fiscal Year: 2012
    ..The fluorescent photomontages of whole mounts of the treated retinas will be analyzed using standard cell count methods and nearest neighbor and spatial clustering analyses techniques...
  20. IMPACT OF INTESTINAL DYSFUNCTION ON ANTIRETROVIRAL THERAPY IN INDIA
    RITA CAROLINE ISAAC; Fiscal Year: 2012
    ..Aim 2 will determine the association between intestinal dysfunction and response to HAART as measured by CD4 cell count and BMI at baseline, 6 and 12 months and viral load and viral resistance mutation at baseline and 12 months in a ..
  21. Nutrition and HIV Progression
    Christine A Wanke; Fiscal Year: 2013
    ..Outcomes in this study will include the need for the initiation of HAART, the rate of decline of CD4 cell count, overall nutritional status as measured by BMI and lean body mass, and quality of life...
  22. A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis
    Ying Zheng; Fiscal Year: 2013
    ..healthy and diseased states, but could also revolutionize preclinical testing for therapies to increase blood cell count in diseases where they are low, either because of the disease itself or its therapy...
  23. Novel disposable microchips for HIV-1 viral load
    Utkan Demirci; Fiscal Year: 2013
    ..In contrast, developing countries are using CD4+ cell count and clinical symptoms to guide ART following the WHO guidelines with the exception of infants, where viral load ..
  24. Serologic memory and prevention of Pneumocystis-related COPD in AIDS macaque mode
    Karen A Norris; Fiscal Year: 2011
    ..KEX1 antibody titers in HIV+ humans also predict subsequent risk of Pc pneumonia (PcP), independent of CD4+ T cell count, and low KEX1 titers in HIV-negative smokers are associated with COPD...
  25. Optimizing Vitamin D Treatment in HIV/AIDS: An RCT
    DOUGLAS THOMAS DIETERICH; Fiscal Year: 2013
    ..The primary outcome measure is the change in the CD4+T cell count. Secondary outcomes include changes in CD4+ T cell subsets, markers of inflammation, markers of bone and calcium ..
  26. Cord Blood Biomarkers for Engraftment
    KRISTIN PAGE-CHARTRAND; Fiscal Year: 2013
    ..g. total nucleated cell count [TNC] and Human Leukocyte Antigen [HLA] matching)...
  27. Improving HIV and Alcohol-Related Outcomes among HIV+ Persons in Clinic Settings
    Jeffrey T Parsons; Fiscal Year: 2013
    ..and cognitive-behavioral skills training, to demonstrate significant improvements in viral load, CD4 cell count, and self-reported adherence among a racially and ethnically diverse sample of HIV+ women and men enrolled in a ..
  28. Role of adipocytokines, leptin and adiponectin in breast carcinogenesis
    Dipali Sharma; Fiscal Year: 2013
    ..an increased proportion of tumors were ER negative, had a high S-phase fraction, histologic grade, mitotic cell count, expression levels of proliferation markers, and a larger tumor size...
  29. THE ROLE OF CTL ESCAPE MUTATIONS IN ATTENUATING HIV-1 SUBTYPE C INFECTION
    Carolyn Williamson; Fiscal Year: 2011
    ..project is to identify attenuating mutations that impact of clinical disease progression as measured by CD+4 T-cell count and viral loads...
  30. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2010
    ..For instance, a rapidly rising white blood cell count may occur during infections or leukemic blast crises...
  31. Evaluating a Youth focused economic empowerment approach to HIV Treatment
    FRED M SSEWAMALA; Fiscal Year: 2012
    ..keeping medical appointments, following nutritional recommendations), d) CD4, and HIV-related biomarkers (CD4 T-cell count and viral load);2) explore the impact of the Suubi+Adherence intervention on potential mechanisms of protective ..
  32. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2009
    ..development of HIV-infected smokers are particularly susceptible to Pneumocystis colonization regardless of CD4 cell count or use of prophylaxis...
  33. Immunology and Outcomes after HAART in HIV/TB Coinfection
    Gregory P Bisson; Fiscal Year: 2013
    ..These relationships will be examined in adults with advanced HIV infection (as indicated by a pre-HAART CD4 + T cell count <100 cells/mm3) and active TB disease...
  34. Association between HIV and Survival after Cancer Diagnosis
    Polly A Newcomb; Fiscal Year: 2011
    ..Information on HIV serostatus, viral load, CD4 T-cell count, and highly active antiretroviral therapy (HAART) will be available from patient medical records...
  35. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2013
    ..For instance, a rapidly rising white blood cell count may occur during infections or a leukemic blast crises...
  36. Linking Russian Narcology &HIV Care to Enhance Treatment, Retention, &Outcomes
    Jeffrey H Samet; Fiscal Year: 2013
    ..medical care in 2 consecutive 6 month periods) within 12 months;3) appropriate HIV care (prescribed ART if CD4 cell count is <350 or having a second CD4 count if CD4 >350 within 12 months;and 4) improved HIV health outcomes (CD4 ..
  37. Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected Children
    NATELLA YURIEVNA RAKHMANINA; Fiscal Year: 2012
    ..of developmental changes in CYP2B6 activity on the clinical outcome (measured by HIV-RNA viral load and CD4+ cell count) and toxicity (measured by CNS adverse events) of EFV based therapy in HIV-infected children and adolescents in ..
  38. Same-Day HIV Testing and Treatment Initiation to Improve Retention in Care
    SERENA PATRICIA KOENIG; Fiscal Year: 2013
    ..clinical disease (World Health Organization [WHO] stage 1 or 2) who qualify for ART by immunologic criteria (CD4 cell count d350 cells/mm3) with point-of-care CD4 cell testing at the GHESKIO Center in Port-au-Prince, Haiti...
  39. Natural History and Pathogenesis of HPV/HIV co-infection in Haiti
    Daniel W Fitzgerald; Fiscal Year: 2012
    ..Between 2005 and 2009, HIV infected patients with a CD4 T cell count of 200 - 350 cells/mm3 were randomized to initiate ART immediately or to defer ART until their CD4 T cell count ..
  40. Monitoring Response to ARV Therapy and Development of HIV-1 Drug Resistance
    Macarthur Charles; Fiscal Year: 2012
    ..Laboratory monitoring is done by CD4 T cell count every 6 months. A plasma sample will also be frozen for research purposes every six months...
  41. Evaluating ART for All HIV Seropositives: Can it work with the hardest cases?
    Don C Des Jarlais; Fiscal Year: 2013
    ..a new policy that all HIV seropositives should be offered antiretroviral treatment (ART) regardless of CD4 cell count. The new policy was based primarily on "treatment as prevention" as a method for not only improving the health ..
  42. Sex Differences in Plasma HIV-1 RNA Concentrations
    Elizabeth Connick; Fiscal Year: 2010
    ..Data will be analyzed by linear regression, after adjusting for CD4+ T cell count, age, and race, to estimate the relationship between sex, VL (in plasma and LN cells), and density of CCR5 ..
  43. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..to reveal potential pain mechanisms, including an assessment of cytokine levels (IL-6 and IL- 8), and mast cell count in vulvovaginal tissue;and, (d) to evaluate the importance of the MC1R gene in the development of vulvar pain by ..
  44. A Flow Through Cell Counting Assay
    SIMON BYSTRYAK; Fiscal Year: 2010
    ..HIV-infected people, the World Health Organization (WHO) has urged the development of simple point-of-care CD4 cell count assays designed for resource-limited settings...
  45. Point-of-care CD4 testing to increase antenatal HAART use
    Mwangelwa Mubiana-Mbewe; Fiscal Year: 2013
    ..All women will + immediately be given a routine or urgent referral to ART services dependent on their CD4 cell count. We will use other government sector clinics matched by size, HIV prevalence, ART services in MCH and presence ..
  46. Antiretroviral Therapy Strategies to Lower Cancer Risk in HIV-Infected Persons
    Michael J Silverberg; Fiscal Year: 2013
    ..goal of the current proposal is to formulate evidence-based recommendations about the preferred CD4 T-cell count at which to initiate ART, and the preferred initial ART regimen, that would minimize cancer incidence among HIV-..
  47. Implementing Point of Care CD4 Analysis to Decentralize HIV Care in Rural Africa
    Sheela Shenoi; Fiscal Year: 2013
    ..A major obstacle to ART initiation among newly diagnosed HIV patients in sub-Saharan Africa is CD4 cell count staging to determine eligibility for treatment...
  48. Proof-of-Concept for Card-Based CD4 Cell Counting
    HAROLD EDWARD AYLIFFE; Fiscal Year: 2010
    ..The integrated system will perform a total white blood cell count, absolute CD4+ T cell count, and percent CD4 count using a new volumetric combination electric impedance/..
  49. Sex, Drugs and Consequences of Dropout on HIV Outcomes in WIHS, MACS, and AIEDRP
    SAMANTHA MAWHINNEY-DELSON; Fiscal Year: 2012
    ..between DAU and Highly Active Antiretroviral Therapy adherence by sex;and estimate the association between DAU and clinical HIV outcomes (CD4+ T cell count and HIV-1 RNA) in treated and untreated HIV-1 infected subjects.
  50. Enhance Prevention in Couples (EPIC)
    Wafaa M El-Sadr; Fiscal Year: 2012
    ..interventions: 1) antiretroviral therapy (ART) for the HIV infected partners at threshold of <500 CD4 cell count, 2) couple-focused counseling for decreasing sexual risk behavior and enhancing adherence with ART, and 3) ..
  51. Innate NKT Cells in HIV Infection
    Douglas F Nixon; Fiscal Year: 2013
    ..We will compare NKT cell frequencies in HIV-1 infected subjects with MTB with age and CD4 T cell count matched controls to determine whether MTB is associated with lower NKT cell frequencies...
  52. Circulating Tumor Cells in Non-Small Cell Lung Cancer
    JORGE J NIEVA; Fiscal Year: 2011
    ..To prospectively determine the correlation between circulating tumor cell count and survival in metastatic non-small cell lung cancer 3...
  53. Mother and Infant Retention for Health (MIR4Health)
    ELAINE JANINE ABRAMS; Fiscal Year: 2013
    ..the intervention on other critical outcomes including maternal attendance at 2nd antenatal visit;changes in CD4+ cell count and HIV RNA viral load;Polymerase Chain Reaction (PCR) testing of HIV-exposed infants at 6 weeks;and adherence ..
  54. A Flow Through Cell Counting Assay
    SIMON BYSTRYAK; Fiscal Year: 2013
    ..HIV-infected people, the World Health Organization (WHO) has urged the development of simple point-of-care CD4 cell count assays designed for resource-limited settings...
  55. Laboratory and Statistical Development of Cross-Sectional HIV Incidence Assays
    Susan H Eshleman; Fiscal Year: 2013
    ..Apply those approaches to data from Aim 1 (CD4 cell count, HIV viral load, and data from serologic assays) and Aim 2 (data from the HRM assay) to identify methods for HIV ..
  56. Rapid Oral Test for Therapeutic Response in HIV/AIDS Patients
    SARKA OLIVERA SOUTHERN; Fiscal Year: 2011
    ..The existing tests for the therapeutic monitoring of AIDS are the CD4 T cell count (CD4) and the HIV-RNA viral load (VL)...
  57. Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroCHIP) Study
    Laurence Huang; Fiscal Year: 2013
    ..e., CD4 cell count) is related to the lung microbiome of HIV-infected subjects without acute illness/pneumonia;(3) To determine the ..
  58. Hematopoietic Stem Cells from Human Term Placenta
    Fernando Viteri; Fiscal Year: 2012
    ..more than half of the cord blood units collected are not stored in public cord blood banks, as the stem cell count does not warrant storage for future use...
  59. Antiretroviral Therapy for HIV-Infected Patients
    Roy M Gulick; Fiscal Year: 2012
    ..a standard regimen of 2 nucleoside analogues plus efavirenz (2) to determine CD4 cell count changes and immune responses with the new CCR5 antagonist, maraviroc in subjects on antiretroviral therapy with ..
  60. RISK SCORE FOR CORONARY ANEURYSMS IN KAWASAKI SYNDROME
    Jane Newburger; Fiscal Year: 1992
    ..parameters measured during the acute phase of the disease: serum IgG, white blood count, differential- white-cell count, absolute band count, absolute lymphocyte count, hemoglobin, hematocrit, platelet count, alpha-1-antitrypsin, ..
  61. ProACT Planning Grant
    DAVID TOM HUANG; Fiscal Year: 2013
    ..superior performance for detection of bacterial infection compared to traditional markers such as white blood cell count. Initial European trials testing the ability of procalcitonin to improve antibiotic prescription practices have ..
  62. SIS multicenter study of duration of antibiotics for intraabdominal infection
    Robert G Sawyer; Fiscal Year: 2011
    ..four days of antibiotic therapy to antibiotic therapy terminated one day after normalization of white blood cell count (= 11,000/ul) and normalization of systemic temperature (<38...
  63. Elucidating Biopsychosocial Mediators of HIV Progression
    LYDIA TEMOSHOK; Fiscal Year: 2009
    ..is evidence or theoretical rationale for their relevance to HIV progression;and clinical variables including CD4 cell count, HIV-1 RNA (viral load, VL). Medical status only assessed will be determined at 48 months...
  64. In Vivo Flow Cytometry to Measure Circulating Tumor Load
    David Benaron; Fiscal Year: 2004
    ..by the physical flow of cells in the capillaries past a noninvasive optical detector to quantitate target cell count. In Phase I, we construct a fiber-based noninvasive cell detector, optionally including confocal imaging/spatial-..
  65. HIV Therapy & Interruption RCT in Resource Poor Clinic
    Luis Montaner; Fiscal Year: 2004
    ..reconstitution will be evaluated in conjunction with viral suppression to <400 copies/ml and retention of CD4 cell count above baseline at the final observation when both intermittent and continuous study arms are on therapy...
  66. HIV Therapy & Interruption RCT in Resource Poor Clinic
    Luis J Montaner; Fiscal Year: 2010
    ..reconstitution will be evaluated in conjunction with viral suppression to <400 copies/ml and retention of CD4 cell count above baseline at the final observation when both intermittent and continuous study arms are on therapy...
  67. EFFECTS OF LEAD ON THE IMMUNE SYSTEM OF CHILDREN
    Paula Lutz; Fiscal Year: 1990
    ..tetanus toxoid, measles, or polio; and B cell count. Proposed assays to determine T lymphocyte function are T cell count; ratio of T-helper/T-suppressor subclasses; ..
  68. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..would be detectable far before metastases occurs - for example, a 3 mm tumor contains only 2 percent of the cell count of an 11 mm lesion, and a 5 mm lesion contains only 9 percent of the cell count...
  69. EFFECTS OF ZINC OXIDE WELDING FUME INHALATION
    Paul Blanc; Fiscal Year: 1992
    ..I will analyze BAL for total cell count and differential and measure interleukin 1 (IL-1) and tumor necrosis factor (TNF) by ELISA...
  70. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2001
    ..Pretreatment blood samples will be analyzed for CD4 and CD8 cell counts, white blood cell count with differential, p24 antigen level, beta-2 microglobulin level, and erythrocyte sedimentation rate...
  71. Khat Chewing: Its Association with HIV Status and CD4 T Cells
    Della Berhanu; Fiscal Year: 2009
    ..of such an investigation will also enhance our understanding of how khat may play a role in determining CD4 T cell count in HIV negative individuals...
  72. Integrated Microfluidic Platelet Activation Assay
    Lawrence Leung; Fiscal Year: 2009
    ..Such an instrument will simultaneously provide information regarding cell count and activation states given by the size and dielectric properties of the cells...
  73. Novel MRS Methods to Characterize MCMD
    Karl Goodkin; Fiscal Year: 2007
    ..performance; minor cognitive-motor disorder (MCMD)] and pathophysiological indices (plasma HIV-1 RNA load; CD4 cell count; cytotoxic T lymphocyte count)...
  74. SEQUENTIAL ANALYSIS OF HEMATOLOGIC MEASUREMENTS
    Christine McLaren; Fiscal Year: 1992
    ..evaluation of anemia in hemodialysis patients by examination of the hemoglobin concentration, hematocrit, red cell count, mean corpuscular volume and red cell volume distribution...
  75. HIV/TB in Uganda: Punctuated Antiretroviral Therapy
    Christopher Whalen; Fiscal Year: 2007
    ..We will compare rates of CD4+ cell count decline over 2 years between TB patients who are randomized to either immediate, punctuated ARV therapy given ..
  76. THYMIC FUNCTION IN ADULTS WITH HIV1 DISEASE
    Joseph McCune; Fiscal Year: 2002
    ..of age, radiographic demonstration of thymic tissue was significantly associated with both a higher CD4+ T cell count and a higher percentage and absolute number of circulating naive (CD45RA+CD62L+) CD4+ T cells...
  77. HIV 1 SEQUENCE DIVERSITY AND PEDIATRIC AIDS
    Raphael Viscidi; Fiscal Year: 2000
    ..proposes to collect nucleotide sequence data and data for four clinical phenotypes: (1) viral load, (2) CD4+ T-cell count, (3) clinical classification, and (4) time...
  78. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..pneumoniae) is associated with stroke risk, and that elevated white blood cell count and soluble tumor necrosis factor receptor levels are associated with carotid atherosclerosis...