culture diffusion chambers

Summary

Summary: Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.

Top Publications

  1. pmc Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    Faiyaz Shakeel
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    AAPS PharmSciTech 8:E104. 2007
  2. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
  3. ncbi Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect
    Louise Cole
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Int J Pharm 333:10-6. 2007
  4. ncbi Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: in vitro study
    R Prasad
    Centre for Biomedical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India
    Int J Pharm 333:70-8. 2007
  5. ncbi In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate
    Sonal R Patel
    Vyteris, Inc, Fair Lawn, NJ, USA
    Eur J Pharm Biopharm 66:296-301. 2007
  6. ncbi Skin irritation in transdermal drug delivery systems: a strategy for its reduction
    Koji Kawahara
    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680 4, Kawazu, Iizuka, Fukuoka, 820 8502, Japan
    Pharm Res 24:399-408. 2007
  7. ncbi In vitro percutaneous permeability enhancement of nimodipine by limonene across the excised rat abdominal skin
    Y S R Krishnaiah
    Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Pharmazie 59:942-7. 2004
  8. ncbi Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation
    Sheree E Cross
    Therapeutics Research Unit, Southern Clinical Division, Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Skin Pharmacol Physiol 20:148-54. 2007
  9. ncbi Synthesis and topical delivery of N-alkyl-N-alkyloxycarbonylaminomethyl prodrugs of a model phenolic drug: acetaminophen
    Susruta Majumdar
    Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, United States
    Int J Pharm 337:48-55. 2007
  10. ncbi Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis
    Xue Ming Wu
    Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Control Release 118:189-95. 2007

Detail Information

Publications153 found, 100 shown here

  1. pmc Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    Faiyaz Shakeel
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    AAPS PharmSciTech 8:E104. 2007
    ..These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of aceclofenac...
  2. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
    ..The luminal contents are important for development of neoinflammation following resection. Regulation of tight junctions by luminal factors has not previously been studied in Crohn's disease...
  3. ncbi Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect
    Louise Cole
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Int J Pharm 333:10-6. 2007
    ..A new mechanistic rationale is proposed whereby larger drug solutes inhibit the permeation of Aloe Vera components, but also are then able to interact more effectively with the enhancing factor and be subject to the pull effect...
  4. ncbi Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: in vitro study
    R Prasad
    Centre for Biomedical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India
    Int J Pharm 333:70-8. 2007
    ..Histopathological studies on treated skin samples, gave an insight about the anatomical changes brought by the application of various enhancers. Binary mixture of menthol and ethanol in combination with square wave gave best results...
  5. ncbi In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate
    Sonal R Patel
    Vyteris, Inc, Fair Lawn, NJ, USA
    Eur J Pharm Biopharm 66:296-301. 2007
    ..The in vivo results show that the pharmacokinetics following transdermal iontophoretic delivery are comparable to those after oral, nasal or rectal administration, but do not match those upon subcutaneous injection...
  6. ncbi Skin irritation in transdermal drug delivery systems: a strategy for its reduction
    Koji Kawahara
    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680 4, Kawazu, Iizuka, Fukuoka, 820 8502, Japan
    Pharm Res 24:399-408. 2007
    ..We have studied a possible approach for the reduction of skin irritation by patch formulations that control the rates of skin permeation and elimination of API...
  7. ncbi In vitro percutaneous permeability enhancement of nimodipine by limonene across the excised rat abdominal skin
    Y S R Krishnaiah
    Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Pharmazie 59:942-7. 2004
    ..The results suggest that limonene is useful for enhancing the skin permeability of nimodipine from transdermal therapeutic systems containing HPMC gel as a reservoir...
  8. ncbi Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation
    Sheree E Cross
    Therapeutics Research Unit, Southern Clinical Division, Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Skin Pharmacol Physiol 20:148-54. 2007
    ..No particles could be detected in the lower stratum corneum or viable epidermis by electron microscopy, suggesting that minimal nanoparticle penetration occurs through the human epidermis...
  9. ncbi Synthesis and topical delivery of N-alkyl-N-alkyloxycarbonylaminomethyl prodrugs of a model phenolic drug: acetaminophen
    Susruta Majumdar
    Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, United States
    Int J Pharm 337:48-55. 2007
    ..The flux of NANAOCAM prodrugs of APAP was accurately predicted by the Roberts-Sloan (RS) equation...
  10. ncbi Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis
    Xue Ming Wu
    Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Control Release 118:189-95. 2007
    ..These results suggest that the combination of iontophoresis with microneedle pretreatment may be a useful means to increase skin permeation of high molecular compounds...
  11. ncbi Probing the skin permeation of eicosapentaenoic acid and ketoprofen 2. Comparative depth profiling and metabolism of eicosapentaenoic acid
    Christopher P Thomas
    Welsh School of Pharmacy, Cardiff University, Wales, UK
    Eur J Pharm Biopharm 67:156-65. 2007
    ..However, this link appears to be only part of the solution of EPA enhancement however, as even in non-viable skin ketoprofen had an enhancing affect...
  12. ncbi Impact of antinucleants on transdermal delivery of testosterone from a spray
    Marie Laure Leichtnam
    School of Pharmaceutical Sciences, University of Geneva, 30, quai E Ansermet, CH 1211 Geneva 4, Switzerland
    J Pharm Sci 96:84-92. 2007
    ..The complicated evaporation/volatilization process, which takes place when a spray is pulverized, requires better characterization before the use of supersaturation for testosterone delivery can be optimized...
  13. ncbi Elastic liposomes mediated transdermal delivery of an anti-hypertensive agent: propranolol hydrochloride
    Dinesh Mishra
    Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar MP, 470003 India
    J Pharm Sci 96:145-55. 2007
    ....
  14. ncbi In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations
    Jürgen Reichling
    Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    Eur J Pharm Biopharm 64:222-8. 2006
    ..36+/-0.21 x 10(-7) cm/s) and semisolid O/W emulsion (8.41+/-0.15 x 10(-7) cm/s) demonstrated higher values indicating a penetration enhancement. No relationship between permeation and liberation was found...
  15. ncbi High-performance liquid chromatographic determination of sumatriptan after in vitro transdermal diffusion studies
    A Femenía-Font
    Departamento de Fisiologia, Farmacologia y Toxicologia, Facultad de Ciencias Experimentales y de la Salud, Universidad Cardenal Herrera CEU, 46113 Moncada, Spain
    J Pharm Biomed Anal 37:621-6. 2005
    ..The detector response, at 282.7 nm, was found to be linear in a concentration range between 0.145 and 145 microM. The limit of detection (LOD) was 0.019 microM and the limit of quantification (LOQ) was 0.145 microM...
  16. ncbi Estimation of transdermal permeation parameters in non-stationary diffusion experiments. Application to pre-treatment studies with terpenes
    A Boix
    Biopharmaceutics and Pharmacokinetics Department, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain
    Pharm Res 22:94-102. 2005
    ..To estimate the applicability of transdermal drug permeation parameters in a finite-dose model for skin pre-treated with terpenes and to evaluate the enhancing effect of some terpene formulations on alprazolam permeation...
  17. ncbi Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Toxicol Lett 159:252-60. 2005
    ....
  18. ncbi Evaluation of constant current alternating current iontophoresis for transdermal drug delivery
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, 84112, USA
    J Control Release 110:141-50. 2005
    ..2 ma)...
  19. ncbi Niosomes as carriers for tretinoin. III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin
    Maria Manconi
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Int J Pharm 311:11-9. 2006
    ..Moreover, interactions between skin and vesicles seem to depend on physico-chemical properties of the main component of the vesicular bilayer...
  20. ncbi The in vitro permeability coefficient and short-term absorption rates for vinyl toluene using human cadaver skin mounted in a static diffusion cell model
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Drug Chem Toxicol 29:39-55. 2006
    ....
  21. ncbi Effects of pressure sensitive adhesives and chemical permeation enhancers on the permeability of fentanyl through excised rat skin
    Amir Mehdizadeh
    Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran
    Acta Pharm 56:219-29. 2006
    ..It was concluded that propylene glycol as a CPE and cosolvent in 10% (m/m) with 3% fentanyl loading in Duro-Tak 2054 showed an effective monolithic DIAP for the development of a transdermal therapeutic system for fentanyl...
  22. ncbi Synthesis and enhancing effect of transkarbam 12 on the transdermal delivery of theophylline, clotrimazole, flobufen, and griseofulvin
    Alexandr Hrabálek
    Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, 50012 Hradec Králové, Czech Republic
    Pharm Res 23:912-9. 2006
    ..We hypothesized that DDEAC reacts with air CO2 to form a two-chain ammonium carbamate--Transkarbam 12 (T12)--which is responsible for the enhancing effect...
  23. ncbi A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives
    Miranda de Jager
    Department of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, University of Leiden, PO Box 9052, 2300 RA Leiden, The Netherlands
    Pharm Res 23:951-60. 2006
    ..The composition, organization, and orientation of lipids in the SCS bear high resemblance to that of the intercellular barrier lipids in SC...
  24. ncbi Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs
    Ines Zurdo Schroeder
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbruecken, Germany
    J Control Release 118:196-203. 2007
    ..These promising results encourage the further development of film forming polymeric solutions as novel transdermal dosage form...
  25. ncbi Formulation of transdermal drug delivery system: matrix type, and selection of polymer- their evaluation
    Rajesh Kaza
    Sree Vidyanikethan, College of Pharmacy, Sree Sainath Nagar, A Rangampet 517102, Chandragiri Mandal, Chittoor Dt, AP, India
    Curr Drug Discov Technol 3:279-85. 2006
    ..Comparative study shows that there is two fold increases in the percentage of permeation...
  26. ncbi Transdermal delivery of cytochrome C--A 12.4 kDa protein--across intact skin by constant-current iontophoresis
    J Cázares-Delgadillo
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, 30 Quai Ernest Ansermet, 1211, Geneva, Switzerland
    Pharm Res 24:1360-8. 2007
    ..To demonstrate the transdermal iontophoretic delivery of a small (12.4 kDa) protein across intact skin...
  27. ncbi Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity
    Ligang Zhao
    Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China
    Int J Pharm 352:92-103. 2008
    ..989 (P=0.144) for M-LA, r = 0.965 (P = 0.216) for M-CA, r = 0.786 (P = 0.630) for M-SA, and r = 0.996 (P = 0.088) for M-OA...
  28. ncbi Evaluation of in vivo efficacy of topical formulations containing soybean extract
    Sandra R Georgetti
    Department of Pharmaceutical Science, Faculty of Pharmaceutical Sciences of Ribeirao Preto USP, Avenue Do Café s n, CEP 14040 903, Ribeirao Preto, SP, Brazil
    Int J Pharm 352:189-96. 2008
    ..In conclusion, the present results suggest for the first time that formulations containing soybean extract may be a topical source of antioxidant compounds that decrease oxidative damages of the skin...
  29. pmc Enhanced transdermal delivery of salbutamol sulfate via ethosomes
    Ehab R Bendas
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Kasr Elainy St, Cairo, Egypt
    AAPS PharmSciTech 8:E107. 2007
    ....
  30. pmc Formulation and evaluation of ethosomes for transdermal delivery of lamivudine
    Subheet Jain
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala Punjab 147 002 India
    AAPS PharmSciTech 8:E111. 2007
    ..5%) as compared with drug solution (24.9% +/- 1.9%). The results of the characterization studies indicate that lipid perturbation along with elasticity of ethosomes vesicles seems to be the main contributor for improved skin permeation...
  31. pmc Newborn pig skin as model membrane in in vitro drug permeation studies: a technical note
    Francesco Cilurzo
    Istituto di Chimica Farmaceutica e Tossicologica P Pratesi, Universita degli Studi di Milano, Viale Abruzzi, 42 20131 Milan, Italy
    AAPS PharmSciTech 8:E94. 2007
  32. doi Improvement of the experimental setup for skin absorption screening studies with reconstructed skin EPISKIN
    S Gregoire
    L Oreal Recherche, Aulnay sous Bois, France
    Skin Pharmacol Physiol 21:89-97. 2008
    ..The EPISKIN model has been greatly improved in the recent years and it is now possible to develop screening tests for the evaluation of skin penetration with a higher reliability...
  33. ncbi In vitro permeation study of hinokitiol: effects of vehicles and enhancers
    Hyang Hee Joo
    School of Biotechnology and Bioengineering, Institute of Bioscience and Biotechnology, Kangwon National University, Kangwon Do, Korea
    Drug Deliv 15:19-22. 2008
    ..Each was added to the HKL solution (1%) so that the concentration of the enhancer was 1%. Among the enhancers, DP was the most effective and it enhanced the permeation of HKL approximately 5-10 times...
  34. doi Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination
    Woan Ruoh Lee
    Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
    J Control Release 128:200-8. 2008
    ..To reveal the mechanisms underlying these changes, a proteomic technique combined with mass spectrometry was used. This is, to our knowledge, the first report of a laser being used to immunize intact animals...
  35. ncbi Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine
    S Baboota
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi 1100 62, India
    PDA J Pharm Sci Technol 61:276-85. 2007
    ..05). Microbiological studies of TB in microemulsion showed better anti-fungal activity against Candida albicans and Aspergillus flavus as compared to marketed product (P < 0.05)...
  36. ncbi Enhancement of skin penetration of vitamin K using monoolein-based liquid crystalline systems
    Luciana B Lopes
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe, S N, 14040 930, Ribeirao Preto, SP, Brazil
    Eur J Pharm Sci 32:209-15. 2007
    ..These results demonstrate that the topical delivery of vitK incorporated in a lipophilic vehicle is small, but it may be enhanced by MO-based systems, which might be useful to increase the effectiveness of topical vitK therapy...
  37. ncbi Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers
    Marta P Alves
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av Ipiranga 2752, CEP 90610 000, Porto Alegre, RS, Brazil
    Int J Pharm 341:215-20. 2007
    ..The gels containing nanocarriers (GNM-NC, GNM-NS and GNM-NE) were able to release the drug in the viable layer of the skin, comparing to a non-particulated nimesulide-loaded formulation at the same concentration...
  38. ncbi Suitability of excised rabbit ear skin - fresh and frozen - for evaluating transdermal permeation of estradiol
    Sara Nicoli
    Department of Pharmacy, University of Parma, Italy
    Drug Deliv 14:195-9. 2007
    ..Fresh rabbit ear skin demonstrated a reasonable model of human epidermis in the investigation of estradiol permeation starting from both solutions and commercial patches...
  39. ncbi Combined effects of iontophoretic and chemical enhancement on drug delivery. II. Transport across human and murine skin
    L M A Nolan
    School of Chemistry, Trinity College, Dublin 2, Ireland
    Int J Pharm 341:114-24. 2007
    ..The investigation also indicated that the barrier properties of the skin recover following the constant current iontophoresis in the presence of oleic or lauric acids...
  40. ncbi Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration
    Huabing Chen
    College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China
    Int J Pharm 341:78-84. 2007
    ..8 times over control gel. The powerful permeation enhancing ability of HTM with a suitable viscosity makes it promising alternative carrier for transdermal administration of drug molecule at an extremely low concentration...
  41. pmc Quantitative structure-permeation relationship for iontophoretic transport across the skin
    Blaise Mudry
    School of Pharmaceutical Sciences, Geneva, University of Lausanne, 30 Quai Ernest Ansermet, Geneva 4, Switzerland
    J Control Release 122:165-72. 2007
    ..4 consistent with skin's cation permselectivity. In conclusion, this research offers a practical contribution to the development of a predictive structure-transport model of iontophoresis...
  42. pmc Tracking the dephosphorylation of resveratrol triphosphate in skin by confocal Raman microscopy
    Guojin Zhang
    Department of Chemistry, Newark College of Arts and Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Control Release 123:141-7. 2007
    ..Thus, the bioavailability of resveratrol in the epidermis appears to be enhanced upon application of the pro-molecule compared to resveratrol...
  43. ncbi Sumatriptan succinate transdermal delivery systems for the treatment of migraine
    C Balaguer-Fernández
    Departamento de Fisiologia, Farmacologia y Toxicologia, Facultad de Ciencias Experimentales y de la Salud, Universidad CEU Cardenal Herrera, 46113 Moncada, Spain
    J Pharm Sci 97:2102-9. 2008
    ..05). In addition, the application of iontophoresis to the wet methyl cellulose-Azone formulation produced a much higher increase of sumatriptan transdermal flux...
  44. ncbi Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes
    Vaibhav Dubey
    Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar M P, 470003, India
    J Control Release 123:148-54. 2007
    ..Our results suggests that ethosomes are an efficient carrier for dermal and transdermal delivery of MTX...
  45. ncbi First-principles, structure-based transdermal transport model to evaluate lipid partition and diffusion coefficients of hydrophobic permeants solely from stratum corneum permeation experiments
    Joseph Kushner
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Pharm Sci 96:3236-51. 2007
    ....
  46. doi Modulation of dihydroavenanthramide D release and skin penetration by 1,2-alkanediols
    Sandra Heuschkel
    Institute of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, Halle Saale, Germany
    Eur J Pharm Biopharm 70:239-47. 2008
    ..Due to their favorable biopharmaceutical and technological properties, longer chain 1,2-alkanediols represent a valuable class of ingredients for dermal products...
  47. ncbi Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen
    Scott C Wasdo
    Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA
    Pharm Res 21:940-6. 2004
    ....
  48. ncbi In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers
    G C Ceschel
    Pharmaceutical Sciences Department, University of Bologna, Bologna, Italy
    Drug Deliv 9:259-63. 2002
    ..The formulation containing DPPG/ethanol as an enhancer could be a good candidate for a new topical foam, considering its good characteristics of permeability and compliance...
  49. ncbi Temperature influences the postelectroporation permeability state of the skin
    S Narasimha Murthy
    Molecular and Cellular Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Pharm Sci 93:908-15. 2004
    ..The enhanced transport is most likely due to the prolonged postpulse permeable state of the skin. Electroporation at mild hyperthermia temperatures resulted in delivering much higher quantities of macromolecules...
  50. ncbi Dependence of skin permeability on contact area
    Pankaj Karande
    Department of Chemical Engineering University of California, Santa Barbara, California 93106, USA
    Pharm Res 20:257-63. 2003
    ..Our results suggest that an array of smaller reservoirs should thus be more effective in increasing transdermal drug delivery compared to a large single reservoir of the same total area...
  51. ncbi Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Tao Yuan, Taiwan
    J Pharm Pharmacol 55:593-601. 2003
    ..The results showed that skin disruption and inflammation did not necessarily correspond to the enhancing efficiency of the enhancers...
  52. ncbi Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Tao Yuan, Taiwan
    J Pharm Pharmacol 55:1175. 2003
  53. pmc Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system
    Ekapol Limpongsa
    Department of Manufacturing Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    AAPS PharmSciTech 9:464-70. 2008
    ..Further in vitro permeation and in vivo performance studies are required...
  54. ncbi Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs
    Amnon C Sintov
    The Institutes for Applied Research, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, 84105, Israel
    J Control Release 89:311-20. 2003
    ..The results emphasize, therefore, that the new transdermal technology is suitable for therapeutic delivery of poorly penetrating molecules...
  55. ncbi Comparative efficacy of cefoperazone, cefoperazone plus sulbactam, ciprofloxacin, clindamycin, metronidazole, and penicillin G against anaerobic bacteria in an animal model
    J A Moody
    Infectious Disease Section, Veterans Administration Medical Center, Minneapolis, MN 55417
    J Lab Clin Med 115:190-5. 1990
    ..In vivo results with this model confirmed in vitro susceptibilities of all tested antimicrobials except ciprofloxacin and should provide useful indications of the potential clinical efficacy of other new agents against anaerobes...
  56. ncbi Co-culture of Aeromonas salmonicida and host cells in intraperitoneal implants is associated with enhanced bacterial survival
    R A Garduno
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada
    Can J Microbiol 46:674-8. 2000
    ..salmonicida-mediated lysis of host cells may constitute a survival strategy in vivo. The co-culture of bacteria with exudate peritoneal cells may be applicable to the in vivo study of other pathogens...
  57. ncbi The effect of terpene concentrations on the skin penetration of diclofenac sodium
    A Nokhodchi
    Medway School of Pharmacy, Central Ave, University of Kent and Greenwich, Chatham, Kent ME4 4TB, England, United Kingdom
    Int J Pharm 335:97-105. 2007
    ..The most outstanding penetration enhancer was nerolidol, providing an almost 198-fold increase in permeability coefficient of diclofenac sodium, followed by farnesol with a 78-fold increase...
  58. ncbi Radiographic characteristics on conventional radiographs after posterior lumbar interbody fusion: comparative study between radiotranslucent and radiopaque cages
    O Diedrich
    Department of Orthopaedic Surgery, University of Bonn, Bonn, Germany
    J Spinal Disord 14:522-32. 2001
    ..The interpretation of fusion status is notably impaired by the use of radiopaque cages. Criteria to standardize the interpretation and evaluation of radiographic findings after PLIF are discussed...
  59. ncbi Phosphatidylcholine embedded micellar systems: enhanced permeability through rat skin
    Aviram Spernath
    Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Colloid Interface Sci 318:421-9. 2008
    ..Moreover, the combination of PC with HECO40 improved the permeation rate (P) and shortened the lag-time (T(L))...
  60. ncbi Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation
    T A Gilbertson
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124, USA
    J Neurosci 21:4931-41. 2001
    ..4%) to three, and 8 (13.6%) to all of the basic stimuli. Cells with both inward (Na(+)) and outward (K(+)) voltage-activated currents were significantly more broadly tuned to gustatory stimuli than those with only inward currents...
  61. ncbi Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0100, USA
    Int J Pharm 352:129-38. 2008
    ..We conclude that NLS in aqueous ethanol formulations can dramatically increase skin permeability by a mechanism involving synergistic lipid-fluidization activity in the stratum corneum...
  62. ncbi BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines
    Tingjiao Liu
    Section of Oral Pathology, Department of Oral Restitution, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 211:728-35. 2007
    ....
  63. ncbi Simultaneous determination of purine nucleotides, their metabolites and beta-nicotinamide adenine dinucleotide in cerebellar granule cells by ion-pair high performance liquid chromatography
    Sergio Giannattasio
    CNR, Centro di Studio sui Mitocondri e Metabolismo Energetico, Via Amendola 165 A, 70126 Bari, Italy
    Brain Res Brain Res Protoc 10:168-74. 2003
    ..Therefore, this method is suitable to evaluate the energetic state in a variety of cell types, both under normal and dismetabolic conditions, such as after the induction of apoptosis or necrosis...
  64. ncbi Enhanced oromucosal delivery of progesterone via hexosomes
    Nitin K Swarnakar
    Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar M P, 470003, India
    Pharm Res 24:2223-30. 2007
    ..Formulation and characterization of progesterone loaded hexosomes employing a novel method for oromucosal delivery...
  65. ncbi Tissue chamber model of acute inflammation in farm animal species
    P Sidhu
    The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, AL9 7TA, Hertfordshire, UK
    Res Vet Sci 74:67-77. 2003
    ....
  66. ncbi The in vitro transport of pergolide from surfactant-based elastic vesicles through human skin: a suggested mechanism of action
    P Loan Honeywell-Nguyen
    Department of Pharmaceutical Technology, Leiden Amsterdam Center for Drug Research, University of Leiden, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Control Release 86:145-56. 2003
    ..Based on the results obtained, a mechanism of action for the elastic vesicles was proposed...
  67. ncbi Platelet adhesion and arteriolar dilation in the photothrombosis: observation with the rat closed cranial and spinal windows
    Mami Ishikawa
    Clinical Research Unit, National Saitama Hospital, 2 1 Suwa, Saitama 351 0102, Wako City, Japan
    J Neurol Sci 194:59-69. 2002
    ..This model is useful for cerebral and spinal microcirculatory analysis to investigate the platelet-endothelium interaction, the platelet aggregation and the effect of free radicals on cerebral and spinal microcirculation...
  68. ncbi Investigation of nail permeation enhancement by chemical modification using water as a probe
    Gouri G Malhotra
    Unilever Research U S, 45 River Road, Edgewater, New Jersey 07020, USA
    J Pharm Sci 91:312-23. 2002
    ..Barrier integrity of nails was compromised after treatment with effective chemical modifiers. Thus, we have developed a suitable technique to screen nail penetration enhancers using water as a probe...
  69. ncbi [Absence of interaction between thiomersal and aluminum occlusion chambers]
    H Assier-Bonnet
    Service de Dermatologie, , ,
    Ann Dermatol Venereol 128:1025-6. 2001
    ..DISCUSSION: The results did not differ for the two materials. We concluded that positive reactions observed were not caused by interaction between aluminium and thiomersal...
  70. ncbi Effects of inspired oxygen concentration on peripheral microcirculation studied by the rabbit ear chamber method
    M Komori
    Department of Anesthesiology, School of Medicine, Tokyo Women's Medical University, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 Japan
    In Vivo 15:303-8. 2001
    ..These results indicate that inspiration of more than 30% oxygen causes deterioration of the microcirculation...
  71. ncbi Reverse iontophoresis of L-lactate: in vitro and in vivo studies
    Susan Nixon
    Novartis Consumer Health SA, Nyon, Switzerland
    J Pharm Sci 96:3457-65. 2007
    ..Despite these positive findings, however, considerably more research is necessary to eliminate potential artefacts and to facilitate interpretation of the data...
  72. ncbi Regional peptide uptake study in the rat intestinal mucosa: glatiramer acetate as a model drug
    Susan Haupt
    The Hebrew University of Jerusalem, Faculty of Medicine, School of Pharmacy, Israel
    Pharm Res 19:832-7. 2002
    ..To identify regions of the rat intestine that are able to internalize from the lumen oligopeptides, using the model drug glatiramer acetate (GA)...
  73. ncbi Simulation of concentration-time profiles of benzyl-penicillin, enrofloxacin and dihydrostreptomycin in tissue cages in calves
    B Bengtsson
    Department of Antibiotics, National Veterinary Institute, Uppsala, Sweden
    J Vet Pharmacol Ther 25:389-92. 2002
  74. ncbi In vitro evaluation of the permeation enhancing effect of polycarbophil-cysteine conjugates on the cornea of rabbits
    Margit D Hornof
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Althanstr 14, 1090 Vienna, Austria
    J Pharm Sci 91:2588-92. 2002
    ..Therefore, polycarbophil-cysteine conjugates seem to be promising excipients for ocular drug delivery systems where they might be used as safe permeation enhancers...
  75. ncbi Evaluation of the porosity, the tortuosity, and the hindrance factor for the transdermal delivery of hydrophilic permeants in the context of the aqueous pore pathway hypothesis using dual-radiolabeled permeability experiments
    Joseph Kushner
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Pharm Sci 96:3263-82. 2007
    ....
  76. ncbi Bioabsorbable anterior lumbar plate fixation in conjunction with cage-assisted anterior interbody fusion
    Denis J DiAngelo
    School of Biomedical Engineering, University of Tennessee Health Science Center, Memphis, USA
    J Neurosurg 97:447-55. 2002
    ..An in vitro biomechanical study was conducted to determine the effects of anterior stabilization on cage-assisted lumbar interbody fusion biomechanics in a multilevel human cadaveric lumbar spine model...
  77. pmc Newly recruited human monocytes have a preserved responsiveness towards bacterial peptides in terms of CD11b up-regulation and intracellular hydrogen peroxide production
    E Dadfar
    Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet, Karolinska University Hospital, Sweden
    Clin Exp Immunol 148:573-82. 2007
    ..These data strengthen a role for newly recruited interstitial human monocytes in the immediate defence against invading pathogens...
  78. ncbi Development, characterization and in vivo evaluation of benzocaine-loaded liposomes
    Paola Mura
    Department of Pharmaceutical Sciences, University of Florence, Italy
    Eur J Pharm Biopharm 67:86-95. 2007
    ..These results suggest that a suitably developed liposomal formulation of benzocaine can be of actual value for improving its clinical effectiveness in topical anaesthesia...
  79. ncbi Quantitative structure-permeation relationships for solute transport across silicone membranes
    Sandrine Geinoz
    Institut de chimie thérapeutique, BEP, Université de Lausanne CH 1015, Lausanne, Switzerland
    Pharm Res 19:1622-9. 2002
    ..The purpose of this work was to assess the molecular properties that influence solute permeation across siliconemembranes and to compare the results with transport across human skin...
  80. ncbi LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression
    Minghua Wu
    Cancer Research Institute, Central South University, Changsha, 410078 Hunan, People s Republic of China
    J Neurooncol 80:133-42. 2006
    ..Our observations indicated that LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells...
  81. ncbi Permeation of 4-cyanophenol and methyl paraben from powder and saturated aqueous solution through silicone rubber membranes and human skin
    Wayne J Romonchuk
    Chemical Engineering Department, Colorado School of Mines, Golden, Colorado, USA
    J Pharm Sci 95:2526-33. 2006
    ..It is evident that absorption into SRM and skin can occur from powdered chemicals and that surface oils or moisture are unnecessary. However, SRM proved to be a poor surrogate for dermal permeation from powders of CP and MP...
  82. ncbi Skin permeation and stability studies of 5-aminolevulinic acid in a new gel and patch preparation
    C Valenta
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
    J Control Release 107:495-501. 2005
    ..4%, however only about 40% of 5-ALA were chemical stable after 14 days storage in the patch formulation, whereas no degradation of 5-ALA was measured in the cubic gel over 90 days of observation...
  83. ncbi Human skin permeation of Delta8-tetrahydrocannabinol, cannabidiol and cannabinol
    Audra L Stinchcomb
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    J Pharm Pharmacol 56:291-7. 2004
    ..CBD, the most polar of the three drugs, and other more polar cannabinoids will also be the focus of future drug design studies for improved transdermal delivery rates...
  84. pmc Iontophoretically enhanced ciclopirox delivery into and across human nail plate
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:3608-16. 2009
    ..The results demonstrate that iontophoresis was able to deliver an effective amount of CIC into and across the nails, and this suggests the feasibility of a constant voltage battery-powered transungual iontophoretic device...
  85. ncbi In vivo and in vitro activity of ciprofloxacin plus azlocillin against 12 streptococcal isolates in a neutropenic site model
    L R Peterson
    Medical Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417
    Diagn Microbiol Infect Dis 7:127-36. 1987
    ....
  86. doi Human skin penetration of silver nanoparticles through intact and damaged skin
    Francesca Filon Larese
    UCO Medicina del Lavoro, Dipartimento di Scienze di Medicina Pubblica, Universita di Trieste, Via della Pieta 19, 34129 Trieste, Italy
    Toxicology 255:33-7. 2009
    ..We demonstrated for the first time that silver applied as nanoparticles coated with polyvinylpirrolidone is able to permeate the damaged skin in an in vitro diffusion cell system...
  87. ncbi Ovine model for engineering bone segments
    Ming Huei Cheng
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan
    Tissue Eng 11:214-25. 2005
    ..This ovine model may serve as a useful tool to develop clinical osseous tissue-engineering strategies...
  88. doi Measurement of adhesion under flow conditions
    Dennis F Kucik
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    Curr Protoc Cell Biol . 2009
    ..Flow chamber assays are also useful for measuring bacterial adhesion under flow...
  89. doi Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin
    Deon van der Merwe
    Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, Kansas 66506, USA
    Cutan Ocul Toxicol 28:78-82. 2009
    ..Dermal absorption of nanocrystalline MgO and TiO(2) through human skin with intact, functional stratum corneum was not detectable under the conditions of this experiment...
  90. ncbi Investigation of in vitro transdermal absorption of fentanyl from patches placed on skin samples obtained from various anatomic regions of dogs
    Paul C Mills
    School of Veterinary Science, University of Queensland, Brisbane, Queensland 4072, Australia
    Am J Vet Res 65:1697-700. 2004
    ..To investigate in vitro transdermal absorption of fentanyl from patches through skin samples obtained from various anatomic regions of dogs...
  91. pmc Hyperaldosteronism in Klotho-deficient mice
    Stephanie S Fischer
    Physiologisches Institut der Universitat Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Renal Physiol 299:F1171-7. 2010
    ..In conclusion, the present observation disclose that the excessive formation of 1,25(OH)(2)D(3) in Klotho-deficient mice results in extracellular volume depletion, which significantly contributes to the shortening of life span...
  92. ncbi LEGO bricks used as chemotactic chambers: evaluation by a computer-assisted image analysis technique
    A Azzara
    Unit of Haematology, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Scand J Clin Lab Invest 64:579-87. 2004
    ..LEGO bricks are inexpensive, fast and suitable for current diagnostic activity or for research investigations in every laboratory...
  93. ncbi In vitro evaluation of various buccal permeation enhancing systems for PACAP (pituitary adenylate cyclase-activating polypeptide)
    Nina Langoth
    ThioMatrix GmbH, Mitterweg 24, A 6020, Innsbruck, Austria
    Pharm Res 22:2045-50. 2005
    ..In this study the effect of various buccal permeation enhancers on PACAP and FD-4 was evaluated...
  94. ncbi The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin
    A O Gamer
    BASF Aktiengesellschaft, Department of Experimental Toxicology and Ecology, GVT Z 470, Carl Bosch Str 38, D 67056 Ludwigshafen Rhein, Germany
    Toxicol In Vitro 20:301-7. 2006
    ..Therefore, from the absence of internal exposure we conclude that their use in sunscreens does not pose a health risk...
  95. doi Hydrophilic silica aerogels as dermal drug delivery systems--dithranol as a model drug
    U Guenther
    Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Eur J Pharm Biopharm 69:935-42. 2008
    ..Dithranol adsorbed on hydrophilic silica aerogels exhibited superior penetration behaviour compared to that of the standard ointment (dithranol in white soft paraffin)...
  96. pmc The development of Cutina lipogels and gel microemulsion for topical administration of fluconazole
    H M El Laithy
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    AAPS PharmSciTech 3:E35. 2002
    ..05). The antifungal activity of fluconazole showed the widest zone of inhibition with gel microemulsion. The gel microemulsion is an excellent vehicle for fluconazole topical drug delivery...
  97. pmc A simple corneal perfusion chamber for drug penetration and toxicity studies
    M A Thiel
    Department of Ophthalmology, Flinders University of South Australia, Adelaide, Australia
    Br J Ophthalmol 85:450-3. 2001
    ..The tissue clamp sealed the preparation effectively against leakage of macromolecules. CONCLUSION: The new chamber device forms a reliable tool for in vitro drug penetration and toxicity studies in isolated perfused corneoscleral tissue...
  98. ncbi Anti-GM1 antibody facilitates leakage in an in vitro blood-nerve barrier model
    T Kanda
    Department of Neurology and Neuroscience, Tokyo Medical and Dental University Graduate School of Medicine, Japan
    Neurology 55:585-7. 2000
    ..This study provided evidence that anti-GM1 antibody, frequently detected in sera from patients with inflammatory neuropathies, may participate BNB dysfunction and contribute to development of neuropathy...
  99. ncbi [Treatment of diabetes mellitus with transplantation of immunoprotected pancreatic islet tissue]
    B Kulseng
    Institutt for kreftforskning og molekylaerbiologi Det medisinske fakultet Norges teknisk naturvitenskapelige universitet, Trondheim
    Tidsskr Nor Laegeforen 119:4219-23. 1999
    ..We may hope that this immunoisolating technique will establish prolonged survival of allo- or xenografted tissue without immunosuppressive treatment...
  100. ncbi Development of an anaerobic bacterial leakage model
    K S Bae
    Department of Endodontology, Oregon Health Sciences University School of Dentistry, Portland 97201, USA
    J Endod 24:233-5. 1998
    ..The results indicate that leakage of strict anaerobes may be evaluated in a two-chamber system...
  101. ncbi Permeation enhancement of a highly lipophilic drug using supersaturated systems
    K Moser
    Novartis Pharma AG, Technical R and D/PHAD, CH - 4002 Basel, Switzerland
    J Pharm Sci 90:607-16. 2001
    ..75 ( +/- 0.16) x 10(-7) cm(2) s(-1) and ATR-FTIR, D = 1.42 ( +/- 0.26) x 10(-7) cm(2) s(-1)). In addition to the characterization of LAP permeation, ATR-FTIR spectroscopy enabled an examination of solvent transport across the membrane...

Research Grants103 found, 100 shown here

  1. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  2. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ....
  3. ELECTROLYTE AND FLUID TRANSPORT IN OCULAR MEMBRANES
    OSCAR CANDIA; Fiscal Year: 2003
    ..These aims will extend recent original findings of this laboratory. From the accomplishment of these aims, models of lens and corneal physiological function will be provided. ..
  4. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart Goodman; Fiscal Year: 2007
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  5. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  6. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  7. CORE GRANT FOR VISION RESEARCH
    OSCAR CANDIA; Fiscal Year: 2007
    ..NEI funds are requested for 4 of the 7 modules. Our Vision Research Center has facilities with an area of more than 15,000 sq. ft. organized as individual laboratories and common space where modules operate. ..
  8. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  9. Molecular mechanisms in steroid-induced glaucoma.
    John Danias; Fiscal Year: 2010
    ..This project is expected to define targets for pharmacologic intervention in steroid-induced glaucoma and provide knowledge that can potentially be used to understand and treat primary open angle glaucoma as well. ..
  10. Chemokine Directed Cell Trafficking during Continuous Infusion of Wear Particles
    Stuart B Goodman; Fiscal Year: 2010
    ..This research will elucidate important mechanisms of particle-induced, chemokine-directed cell trafficking and suggest new treatment strategies. ..
  11. Electrolyte and Fluid Transport in the Ocular Membranes
    OSCAR CANDIA; Fiscal Year: 2009
    ..Such information is important, because the mechanisms by which the lens maintains its clarity remain obscure, and cataract remains a major cause of blindness worldwide. ..
  12. PH REGULATION IN VENTRICULAR CELLS
    KENNETH SPITZER; Fiscal Year: 2002
    ..The results of this project will yield new information concerning hormonal modulation of cardiac pHi control systems and the action of intracellular and intercellular H+ diffusion to dissipate regional pHi gradients. ..
  13. pH REGULATION IN HEART CELLS
    KENNETH SPITZER; Fiscal Year: 2007
    ..abstract_text> ..
  14. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. ..
  15. PH REGULATION IN VENTRICULAR CELLS
    KENNETH SPITZER; Fiscal Year: 1991
    ..The results should also yield new information, obtained under physiologically realistic conditions, concerning the pH1- contraction relationship in ventricular muscle...
  16. PH REGULATION IN VENTRICULAR CELLS
    KENNETH SPITZER; Fiscal Year: 1993
    ..The results should provide useful new insight concerning the ionic basis of ventricular pHi control...
  17. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2007
    ..abstract_text> ..
  18. STRUCTURE & FUNCTION OF LENS COMMUNICATING CHANNELS
    Guido Zampighi; Fiscal Year: 1993
    ..Similar plots calculated from the primary structure of lens MIP26 suggest six membrane spanning domains. Cryo-electron microscopy and computer image processing will be utilized to experimentally test these predictions...
  19. Estrogen and EDHF in NO Deficiency
    An Huang; Fiscal Year: 2006
    ..The knowledge generated by these studies will unravel the roles of estrogen in the regulation of arteriolar function related specifically to the involvement of EDHF-mediated dilator pathways in adaptation to NO deficiency. ..
  20. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ....
  21. Estrogen: Chrodroprotective or Destructive?
    Sally Frenkel; Fiscal Year: 2002
    ..The inconclusive and contradictory data from human and animal studies render the proposed studies highly significant. ..
  22. NALTREXONE PRODRUGS FOR TRANSDERMAL DELIVERY
    Audra Stinchcomb; Fiscal Year: 2007
    ....
  23. Transscleral Drug Delivery for Retinal Disorders
    Henry Edelhauser; Fiscal Year: 2007
    ..These delivery techniques should be safer and more effective than the state of the art. Ultimately, these results will guide us in enhancing drug treatments in ophthalmic practice. ..
  24. SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURY
    Martin Marsala; Fiscal Year: 2001
    ..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
  25. MULTIDISCIPLINARY TRAINING IN VISION AND RESEARCH
    Henry Edelhauser; Fiscal Year: 2007
    ..In addition, the program successfully attracts minority trainees to careers in fundamental eye research, drawing on the outstanding resources of Atlanta academic and medical institutions. ..
  26. STRUCTURE AND FUNCTION OF LENS CHANNELS
    Guido Zampighi; Fiscal Year: 2003
    ..To study their functional properties, expression in Xenopus laevis oocytes will be used to allow measurements of molecular properties, electrolyte and nonelectrolyte fluxes and water permeability. ..
  27. NALTREXONE PRODRUGS FOR TRANSDERMAL DELIVERY
    Audra Stinchcomb; Fiscal Year: 2009
    ....
  28. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2005
    ....
  29. NALTREXONE PRODRUGS FOR TRANSDERMAL DELIVERY
    Audra Stinchcomb; Fiscal Year: 2004
    ..Correlation of our in vitro data with the in vivo models will aid in the creation of a reliable QSPR database, as well as help to identify the most promising prodrug for eventual human use. ..
  30. Nitric Oxide Defense Against Porphyromonas gingivalis
    Robert Gyurko; Fiscal Year: 2006
    ..He is applying for the NIDCR Scholar Development and Faculty Transition Award to pursue scientific career as an independent investigator at Boston University School of Dental Medicine. ..
  31. Transdermal Codrugs for Treatment of Alcoholism
    Audra Stinchcomb; Fiscal Year: 2006
    ..Correlation of the in vitro data with the in vivo model will aid in the creation of a reliable QSAR database that is necessary to help identify the best co-drugs for clinical use. ..
  32. STRUCTURE AND FUNCTION OF LENS CHANNELS
    Guido Zampighi; Fiscal Year: 2007
    ..We also propose to study the distribution and interaction of connexin and aquaporin channels in the native fiber environment and in the Xenopus oocyte expression system. ..
  33. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....