culture diffusion chambers

Summary

Summary: Devices used in a technique by which cells or tissues are grown in vitro or, by implantation, in vivo within chambers permeable to diffusion of solutes across the chamber walls. The chambers are used for studies of drug effects, osmotic responses, cytogenic and immunologic phenomena, metabolism, etc., and include tissue cages.

Top Publications

  1. pmc Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    Faiyaz Shakeel
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    AAPS PharmSciTech 8:E104. 2007
  2. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
  3. ncbi Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect
    Louise Cole
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Int J Pharm 333:10-6. 2007
  4. ncbi Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Tao Yuan, Taiwan
    J Pharm Pharmacol 55:593-601. 2003
  5. ncbi A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives
    Miranda de Jager
    Department of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, University of Leiden, PO Box 9052, 2300 RA Leiden, The Netherlands
    Pharm Res 23:951-60. 2006
  6. ncbi In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations
    Jürgen Reichling
    Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    Eur J Pharm Biopharm 64:222-8. 2006
  7. ncbi Elastic liposomes mediated transdermal delivery of an anti-hypertensive agent: propranolol hydrochloride
    Dinesh Mishra
    Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar MP, 470003 India
    J Pharm Sci 96:145-55. 2007
  8. ncbi Impact of antinucleants on transdermal delivery of testosterone from a spray
    Marie Laure Leichtnam
    School of Pharmaceutical Sciences, University of Geneva, 30, quai E Ansermet, CH 1211 Geneva 4, Switzerland
    J Pharm Sci 96:84-92. 2007
  9. ncbi Suitability of excised rabbit ear skin - fresh and frozen - for evaluating transdermal permeation of estradiol
    Sara Nicoli
    Department of Pharmacy, University of Parma, Italy
    Drug Deliv 14:195-9. 2007
  10. ncbi Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: in vitro study
    R Prasad
    Centre for Biomedical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India
    Int J Pharm 333:70-8. 2007

Detail Information

Publications199 found, 100 shown here

  1. pmc Nanoemulsions as vehicles for transdermal delivery of aceclofenac
    Faiyaz Shakeel
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    AAPS PharmSciTech 8:E104. 2007
    ..These results suggested that nanoemulsions are potential vehicles for improved transdermal delivery of aceclofenac...
  2. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
    ..The luminal contents are important for development of neoinflammation following resection. Regulation of tight junctions by luminal factors has not previously been studied in Crohn's disease...
  3. ncbi Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect
    Louise Cole
    Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, United Kingdom
    Int J Pharm 333:10-6. 2007
    ..A new mechanistic rationale is proposed whereby larger drug solutes inhibit the permeation of Aloe Vera components, but also are then able to interact more effectively with the enhancing factor and be subject to the pull effect...
  4. ncbi Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Tao Yuan, Taiwan
    J Pharm Pharmacol 55:593-601. 2003
    ..The results showed that skin disruption and inflammation did not necessarily correspond to the enhancing efficiency of the enhancers...
  5. ncbi A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives
    Miranda de Jager
    Department of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, University of Leiden, PO Box 9052, 2300 RA Leiden, The Netherlands
    Pharm Res 23:951-60. 2006
    ..The composition, organization, and orientation of lipids in the SCS bear high resemblance to that of the intercellular barrier lipids in SC...
  6. ncbi In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations
    Jürgen Reichling
    Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    Eur J Pharm Biopharm 64:222-8. 2006
    ..36+/-0.21 x 10(-7) cm/s) and semisolid O/W emulsion (8.41+/-0.15 x 10(-7) cm/s) demonstrated higher values indicating a penetration enhancement. No relationship between permeation and liberation was found...
  7. ncbi Elastic liposomes mediated transdermal delivery of an anti-hypertensive agent: propranolol hydrochloride
    Dinesh Mishra
    Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar MP, 470003 India
    J Pharm Sci 96:145-55. 2007
    ....
  8. ncbi Impact of antinucleants on transdermal delivery of testosterone from a spray
    Marie Laure Leichtnam
    School of Pharmaceutical Sciences, University of Geneva, 30, quai E Ansermet, CH 1211 Geneva 4, Switzerland
    J Pharm Sci 96:84-92. 2007
    ..The complicated evaporation/volatilization process, which takes place when a spray is pulverized, requires better characterization before the use of supersaturation for testosterone delivery can be optimized...
  9. ncbi Suitability of excised rabbit ear skin - fresh and frozen - for evaluating transdermal permeation of estradiol
    Sara Nicoli
    Department of Pharmacy, University of Parma, Italy
    Drug Deliv 14:195-9. 2007
    ..Fresh rabbit ear skin demonstrated a reasonable model of human epidermis in the investigation of estradiol permeation starting from both solutions and commercial patches...
  10. ncbi Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: in vitro study
    R Prasad
    Centre for Biomedical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India
    Int J Pharm 333:70-8. 2007
    ..Histopathological studies on treated skin samples, gave an insight about the anatomical changes brought by the application of various enhancers. Binary mixture of menthol and ethanol in combination with square wave gave best results...
  11. ncbi In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate
    Sonal R Patel
    Vyteris, Inc, Fair Lawn, NJ, USA
    Eur J Pharm Biopharm 66:296-301. 2007
    ..The in vivo results show that the pharmacokinetics following transdermal iontophoretic delivery are comparable to those after oral, nasal or rectal administration, but do not match those upon subcutaneous injection...
  12. ncbi Skin irritation in transdermal drug delivery systems: a strategy for its reduction
    Koji Kawahara
    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680 4, Kawazu, Iizuka, Fukuoka, 820 8502, Japan
    Pharm Res 24:399-408. 2007
    ..We have studied a possible approach for the reduction of skin irritation by patch formulations that control the rates of skin permeation and elimination of API...
  13. ncbi Synthesis and topical delivery of N-alkyl-N-alkyloxycarbonylaminomethyl prodrugs of a model phenolic drug: acetaminophen
    Susruta Majumdar
    Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, United States
    Int J Pharm 337:48-55. 2007
    ..The flux of NANAOCAM prodrugs of APAP was accurately predicted by the Roberts-Sloan (RS) equation...
  14. ncbi The in vitro permeability coefficient and short-term absorption rates for vinyl toluene using human cadaver skin mounted in a static diffusion cell model
    William J Fasano
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
    Drug Chem Toxicol 29:39-55. 2006
    ....
  15. ncbi Niosomes as carriers for tretinoin. III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin
    Maria Manconi
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Int J Pharm 311:11-9. 2006
    ..Moreover, interactions between skin and vesicles seem to depend on physico-chemical properties of the main component of the vesicular bilayer...
  16. ncbi Efficacy and irritancy of enhancers on the in-vitro and in-vivo percutaneous absorption of curcumin
    Jia You Fang
    Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Tao Yuan, Taiwan
    J Pharm Pharmacol 55:1175. 2003
  17. ncbi Temperature influences the postelectroporation permeability state of the skin
    S Narasimha Murthy
    Molecular and Cellular Biophysics Department, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Pharm Sci 93:908-15. 2004
    ..The enhanced transport is most likely due to the prolonged postpulse permeable state of the skin. Electroporation at mild hyperthermia temperatures resulted in delivering much higher quantities of macromolecules...
  18. ncbi Topical delivery of a model phenolic drug: alkyloxycarbonyl prodrugs of acetaminophen
    Scott C Wasdo
    Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, USA
    Pharm Res 21:940-6. 2004
    ....
  19. ncbi Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation
    Sheree E Cross
    Therapeutics Research Unit, Southern Clinical Division, Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia
    Skin Pharmacol Physiol 20:148-54. 2007
    ..No particles could be detected in the lower stratum corneum or viable epidermis by electron microscopy, suggesting that minimal nanoparticle penetration occurs through the human epidermis...
  20. ncbi Dependence of skin permeability on contact area
    Pankaj Karande
    Department of Chemical Engineering University of California, Santa Barbara, California 93106, USA
    Pharm Res 20:257-63. 2003
    ..Our results suggest that an array of smaller reservoirs should thus be more effective in increasing transdermal drug delivery compared to a large single reservoir of the same total area...
  21. ncbi In vitro percutaneous permeability enhancement of nimodipine by limonene across the excised rat abdominal skin
    Y S R Krishnaiah
    Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Pharmazie 59:942-7. 2004
    ..The results suggest that limonene is useful for enhancing the skin permeability of nimodipine from transdermal therapeutic systems containing HPMC gel as a reservoir...
  22. ncbi High-performance liquid chromatographic determination of sumatriptan after in vitro transdermal diffusion studies
    A Femenía-Font
    Departamento de Fisiologia, Farmacologia y Toxicologia, Facultad de Ciencias Experimentales y de la Salud, Universidad Cardenal Herrera CEU, 46113 Moncada, Spain
    J Pharm Biomed Anal 37:621-6. 2005
    ..The detector response, at 282.7 nm, was found to be linear in a concentration range between 0.145 and 145 microM. The limit of detection (LOD) was 0.019 microM and the limit of quantification (LOQ) was 0.145 microM...
  23. ncbi In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers
    G C Ceschel
    Pharmaceutical Sciences Department, University of Bologna, Bologna, Italy
    Drug Deliv 9:259-63. 2002
    ..The formulation containing DPPG/ethanol as an enhancer could be a good candidate for a new topical foam, considering its good characteristics of permeability and compliance...
  24. ncbi Estimation of transdermal permeation parameters in non-stationary diffusion experiments. Application to pre-treatment studies with terpenes
    A Boix
    Biopharmaceutics and Pharmacokinetics Department, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain
    Pharm Res 22:94-102. 2005
    ..To estimate the applicability of transdermal drug permeation parameters in a finite-dose model for skin pre-treated with terpenes and to evaluate the enhancing effect of some terpene formulations on alprazolam permeation...
  25. ncbi Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Toxicol Lett 159:252-60. 2005
    ....
  26. ncbi Evaluation of constant current alternating current iontophoresis for transdermal drug delivery
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, 84112, USA
    J Control Release 110:141-50. 2005
    ..2 ma)...
  27. ncbi Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis
    Xue Ming Wu
    Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Control Release 118:189-95. 2007
    ..These results suggest that the combination of iontophoresis with microneedle pretreatment may be a useful means to increase skin permeation of high molecular compounds...
  28. ncbi Probing the skin permeation of eicosapentaenoic acid and ketoprofen 2. Comparative depth profiling and metabolism of eicosapentaenoic acid
    Christopher P Thomas
    Welsh School of Pharmacy, Cardiff University, Wales, UK
    Eur J Pharm Biopharm 67:156-65. 2007
    ..However, this link appears to be only part of the solution of EPA enhancement however, as even in non-viable skin ketoprofen had an enhancing affect...
  29. ncbi Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity
    Ligang Zhao
    Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China
    Int J Pharm 352:92-103. 2008
    ..989 (P=0.144) for M-LA, r = 0.965 (P = 0.216) for M-CA, r = 0.786 (P = 0.630) for M-SA, and r = 0.996 (P = 0.088) for M-OA...
  30. ncbi Evaluation of in vivo efficacy of topical formulations containing soybean extract
    Sandra R Georgetti
    Department of Pharmaceutical Science, Faculty of Pharmaceutical Sciences of Ribeirao Preto USP, Avenue Do Café s n, CEP 14040 903, Ribeirao Preto, SP, Brazil
    Int J Pharm 352:189-96. 2008
    ..In conclusion, the present results suggest for the first time that formulations containing soybean extract may be a topical source of antioxidant compounds that decrease oxidative damages of the skin...
  31. pmc Enhanced transdermal delivery of salbutamol sulfate via ethosomes
    Ehab R Bendas
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Kasr Elainy St, Cairo, Egypt
    AAPS PharmSciTech 8:E107. 2007
    ....
  32. pmc Formulation and evaluation of ethosomes for transdermal delivery of lamivudine
    Subheet Jain
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala Punjab 147 002 India
    AAPS PharmSciTech 8:E111. 2007
    ..5%) as compared with drug solution (24.9% +/- 1.9%). The results of the characterization studies indicate that lipid perturbation along with elasticity of ethosomes vesicles seems to be the main contributor for improved skin permeation...
  33. pmc Newborn pig skin as model membrane in in vitro drug permeation studies: a technical note
    Francesco Cilurzo
    Istituto di Chimica Farmaceutica e Tossicologica P Pratesi, Universita degli Studi di Milano, Viale Abruzzi, 42 20131 Milan, Italy
    AAPS PharmSciTech 8:E94. 2007
  34. ncbi Improvement of the experimental setup for skin absorption screening studies with reconstructed skin EPISKIN
    S Gregoire
    L Oreal Recherche, Aulnay sous Bois, France
    Skin Pharmacol Physiol 21:89-97. 2008
    ..The EPISKIN model has been greatly improved in the recent years and it is now possible to develop screening tests for the evaluation of skin penetration with a higher reliability...
  35. ncbi In vitro permeation study of hinokitiol: effects of vehicles and enhancers
    Hyang Hee Joo
    School of Biotechnology and Bioengineering, Institute of Bioscience and Biotechnology, Kangwon National University, Kangwon Do, Korea
    Drug Deliv 15:19-22. 2008
    ..Each was added to the HKL solution (1%) so that the concentration of the enhancer was 1%. Among the enhancers, DP was the most effective and it enhanced the permeation of HKL approximately 5-10 times...
  36. pmc Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system
    Ekapol Limpongsa
    Department of Manufacturing Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    AAPS PharmSciTech 9:464-70. 2008
    ..Further in vitro permeation and in vivo performance studies are required...
  37. ncbi Erbium:YAG laser enhances transdermal peptide delivery and skin vaccination
    Woan Ruoh Lee
    Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
    J Control Release 128:200-8. 2008
    ..To reveal the mechanisms underlying these changes, a proteomic technique combined with mass spectrometry was used. This is, to our knowledge, the first report of a laser being used to immunize intact animals...
  38. ncbi Modulation of dihydroavenanthramide D release and skin penetration by 1,2-alkanediols
    Sandra Heuschkel
    Institute of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, Halle Saale, Germany
    Eur J Pharm Biopharm 70:239-47. 2008
    ..Due to their favorable biopharmaceutical and technological properties, longer chain 1,2-alkanediols represent a valuable class of ingredients for dermal products...
  39. ncbi Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine
    S Baboota
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi 1100 62, India
    PDA J Pharm Sci Technol 61:276-85. 2007
    ..05). Microbiological studies of TB in microemulsion showed better anti-fungal activity against Candida albicans and Aspergillus flavus as compared to marketed product (P < 0.05)...
  40. ncbi Enhancement of skin penetration of vitamin K using monoolein-based liquid crystalline systems
    Luciana B Lopes
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe, S N, 14040 930, Ribeirao Preto, SP, Brazil
    Eur J Pharm Sci 32:209-15. 2007
    ..These results demonstrate that the topical delivery of vitK incorporated in a lipophilic vehicle is small, but it may be enhanced by MO-based systems, which might be useful to increase the effectiveness of topical vitK therapy...
  41. ncbi Effects of pressure sensitive adhesives and chemical permeation enhancers on the permeability of fentanyl through excised rat skin
    Amir Mehdizadeh
    Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran
    Acta Pharm 56:219-29. 2006
    ..It was concluded that propylene glycol as a CPE and cosolvent in 10% (m/m) with 3% fentanyl loading in Duro-Tak 2054 showed an effective monolithic DIAP for the development of a transdermal therapeutic system for fentanyl...
  42. ncbi Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs
    Ines Zurdo Schroeder
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbruecken, Germany
    J Control Release 118:196-203. 2007
    ..These promising results encourage the further development of film forming polymeric solutions as novel transdermal dosage form...
  43. ncbi Formulation of transdermal drug delivery system: matrix type, and selection of polymer- their evaluation
    Rajesh Kaza
    Sree Vidyanikethan, College of Pharmacy, Sree Sainath Nagar, A Rangampet 517102, Chandragiri Mandal, Chittoor Dt, AP, India
    Curr Drug Discov Technol 3:279-85. 2006
    ..Comparative study shows that there is two fold increases in the percentage of permeation...
  44. ncbi Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers
    Marta P Alves
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av Ipiranga 2752, CEP 90610 000, Porto Alegre, RS, Brazil
    Int J Pharm 341:215-20. 2007
    ..The gels containing nanocarriers (GNM-NC, GNM-NS and GNM-NE) were able to release the drug in the viable layer of the skin, comparing to a non-particulated nimesulide-loaded formulation at the same concentration...
  45. ncbi Combined effects of iontophoretic and chemical enhancement on drug delivery. II. Transport across human and murine skin
    L M A Nolan
    School of Chemistry, Trinity College, Dublin 2, Ireland
    Int J Pharm 341:114-24. 2007
    ..The investigation also indicated that the barrier properties of the skin recover following the constant current iontophoresis in the presence of oleic or lauric acids...
  46. ncbi Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration
    Huabing Chen
    College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China
    Int J Pharm 341:78-84. 2007
    ..8 times over control gel. The powerful permeation enhancing ability of HTM with a suitable viscosity makes it promising alternative carrier for transdermal administration of drug molecule at an extremely low concentration...
  47. pmc Quantitative structure-permeation relationship for iontophoretic transport across the skin
    Blaise Mudry
    School of Pharmaceutical Sciences, Geneva, University of Lausanne, 30 Quai Ernest Ansermet, Geneva 4, Switzerland
    J Control Release 122:165-72. 2007
    ..4 consistent with skin's cation permselectivity. In conclusion, this research offers a practical contribution to the development of a predictive structure-transport model of iontophoresis...
  48. ncbi Sumatriptan succinate transdermal delivery systems for the treatment of migraine
    C Balaguer-Fernández
    Departamento de Fisiologia, Farmacologia y Toxicologia, Facultad de Ciencias Experimentales y de la Salud, Universidad CEU Cardenal Herrera, 46113 Moncada, Spain
    J Pharm Sci 97:2102-9. 2008
    ..05). In addition, the application of iontophoresis to the wet methyl cellulose-Azone formulation produced a much higher increase of sumatriptan transdermal flux...
  49. ncbi Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes
    Vaibhav Dubey
    Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University, Sagar M P, 470003, India
    J Control Release 123:148-54. 2007
    ..Our results suggests that ethosomes are an efficient carrier for dermal and transdermal delivery of MTX...
  50. ncbi First-principles, structure-based transdermal transport model to evaluate lipid partition and diffusion coefficients of hydrophobic permeants solely from stratum corneum permeation experiments
    Joseph Kushner
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Pharm Sci 96:3236-51. 2007
    ....
  51. ncbi Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs
    Amnon C Sintov
    The Institutes for Applied Research, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, 84105, Israel
    J Control Release 89:311-20. 2003
    ..The results emphasize, therefore, that the new transdermal technology is suitable for therapeutic delivery of poorly penetrating molecules...
  52. ncbi Comparative efficacy of cefoperazone, cefoperazone plus sulbactam, ciprofloxacin, clindamycin, metronidazole, and penicillin G against anaerobic bacteria in an animal model
    J A Moody
    Infectious Disease Section, Veterans Administration Medical Center, Minneapolis, MN 55417
    J Lab Clin Med 115:190-5. 1990
    ..In vivo results with this model confirmed in vitro susceptibilities of all tested antimicrobials except ciprofloxacin and should provide useful indications of the potential clinical efficacy of other new agents against anaerobes...
  53. ncbi A commercially available cell culture device modified for dentin barrier tests
    G Schmalz
    Clinic of Operative Dentistry and Periodontology, University of Regensburg, Germany
    J Endod 22:249-52. 1996
    ..The light-curing glass ionomer cement (vitrebond) and zinc oxide-eugenol killed all cells. These results agree with those obtained from a previous study, wherein the dentin barrier test device was constructed in our laboratory...
  54. ncbi Regional intestinal absorption of FITC-dextran 4,400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats
    Koji Nakamura
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    J Pharm Sci 92:311-8. 2003
    ..These findings suggested that absorption enhancement by Sit-G NP may not be due to opening of a tight junction, but might be related to endocytosis via glucose residue of Sit-G...
  55. ncbi Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid
    Aiko Iida
    Department of Drug Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
    Drug Metab Pharmacokinet 21:424-8. 2006
    ....
  56. ncbi Revisiting the Münch pressure-flow hypothesis for long-distance transport of carbohydrates: modelling the dynamics of solute transport inside a semipermeable tube
    S M Henton
    Horticultural Research, Batchelor Research Centre, Private Bag 11030, Palmerston North, New Zealand
    J Exp Bot 53:1411-9. 2002
    ....
  57. ncbi Meconium-stained amniotic fluid activates polymorphonuclear leukocytes ultrastructural and enzyme-cytochemical evidence
    S Matsubara
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    Eur J Histochem 43:205-10. 1999
    ..Meconium-stained amniotic fluid induced leukocyte activation might play important roles in the pathophysiology of initiation of term labor or of the meconium aspiration syndrome...
  58. pmc Novel human bronchial epithelial cell lines for cystic fibrosis research
    M L Fulcher
    Univ of North Carolina Cystic Fibrosis Center, CB 7248, Rm 4011 Thurston Bowles Bldg, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 296:L82-91. 2009
    ....
  59. ncbi Cardiac tissue engineering in an in vivo vascularized chamber
    Andrew N Morritt
    Bernard O Brien Institute of Microsurgery, 42 Fitzroy St, Fitzroy, 3065 Victoria, Australia
    Circulation 115:353-60. 2007
    ..Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating cardiac muscle in the rat that are as thick as the adult rat right ventricle wall...
  60. ncbi Multipulse drug permeation across a membrane driven by a chemical pH-oscillator
    Gauri P Misra
    Department of Pharmaceutics, University of Minnesota, 308 Harvard St SE, 9 177 Weaver Densford Hall, Minneapolis, MN 55419, USA
    J Control Release 79:293-7. 2002
    ..Advantage is taken of a pH oscillator system whose periodicity is slower than that of previously considered oscillators...
  61. ncbi Co-culture of Aeromonas salmonicida and host cells in intraperitoneal implants is associated with enhanced bacterial survival
    R A Garduno
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada
    Can J Microbiol 46:674-8. 2000
    ..salmonicida-mediated lysis of host cells may constitute a survival strategy in vivo. The co-culture of bacteria with exudate peritoneal cells may be applicable to the in vivo study of other pathogens...
  62. ncbi Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight
    Andreas Billich
    Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A 1235 Vienna, Austria
    Bioorg Med Chem 13:3157-67. 2005
    ..Results also indicate that in principle higher skin levels of active drug can be attained with a prodrug strategy in this class of compounds...
  63. ncbi Gender differences in systemic inflammation and atheroma formation following Porphyromonas gingivalis infection in heterozygous apolipoprotein E-deficient mice
    C Champagne
    Center for Oral and Systemic Diseases, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7450, USA
    J Periodontal Res 44:569-77. 2009
    ..In this study, we investigated whether infection with a major periodontal pathogen, Porphyromonas gingivalis, affected the inflammatory and atherosclerotic response of male and female mice differently...
  64. ncbi Hematopoietic differentiation of embryonic stem cells
    Irina Orlovskaya
    Institute for Clinical Immunology, Yadrinzovskaya 14, Novosibirsk 630090, Russian Federation
    Methods 45:159-67. 2008
    ....
  65. ncbi Dielectrophoretic assembly of insulinoma cells and fluorescent nanosensors into three-dimensional pseudo-islet constructs
    R Pethig
    BioCurrents Research Centre, Program in Molecular Physiology, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    IET Nanobiotechnol 2:31. 2008
    ..The footprint of the 10 x 10 array of cell constructs was compatible with that of a 1536 microtitre plate, and thus amenable to optical interrogation using automated plate reading equipment...
  66. ncbi Primary clear-cell chondrosarcoma of the cervical spine. Case illustration
    Enrico Tessitore
    Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland
    J Neurosurg Spine 4:424. 2006
  67. ncbi Synthesis and enhancing effect of transkarbam 12 on the transdermal delivery of theophylline, clotrimazole, flobufen, and griseofulvin
    Alexandr Hrabálek
    Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, 50012 Hradec Králové, Czech Republic
    Pharm Res 23:912-9. 2006
    ..We hypothesized that DDEAC reacts with air CO2 to form a two-chain ammonium carbamate--Transkarbam 12 (T12)--which is responsible for the enhancing effect...
  68. ncbi Double-decker chemotaxis: no evidence for photonic stimulation of directed locomotion by human blood polymorphonuclear leukocytes
    Leonard S Kaplow
    Bradford, Vermont
    Cell Motil Cytoskeleton 53:289-92. 2002
    ..Only random PMN locomotion was observed in the adjacent chamber. The results indicate that in this experimental model, electromagnetic forces do not initiate directed locomotion...
  69. pmc Tracking the dephosphorylation of resveratrol triphosphate in skin by confocal Raman microscopy
    Guojin Zhang
    Department of Chemistry, Newark College of Arts and Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Control Release 123:141-7. 2007
    ..Thus, the bioavailability of resveratrol in the epidermis appears to be enhanced upon application of the pro-molecule compared to resveratrol...
  70. ncbi In vitro and in vivo degradation of bioabsorbable PLLA spinal fusion cages
    M van Dijk
    Department of Orthopaedic Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Biomed Mater Res 63:752-9. 2002
    ..Despite the high-load-bearing conditions, the poly-L-lactic acid cage allowed interbody fusion to occur without collapse of the cage...
  71. ncbi Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis
    Lilian Soon
    Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, Bronx, New York, USA
    Cell Motil Cytoskeleton 62:27-34. 2005
    ..This result suggests that polarized cancer cells can avoid the need for oscillatory path corrections during chemotaxis...
  72. ncbi Transcriptional modulation of some Staphylococcus aureus iron-regulated genes during growth in vitro and in a tissue cage model in vivo
    Marianne Allard
    Centre d Étude et de Valorisation de la Diversité Microbienne CEVDM, Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Microbes Infect 8:1679-90. 2006
    ..The expression of iron-regulated genes in distinct low-iron environments provided insight into their relative importance in vitro and in vivo and their usefulness for vaccine and drug development...
  73. ncbi The effect of zaldaride maleate, an antidiarrheal compound, on acetylcholine-induced intestinal electrolyte secretion
    N Aikawa
    The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka, Japan
    Biol Pharm Bull 23:1377-8. 2000
    ..Zaldaride may reduce colonic electrolyte secretion by acetylcholine due to the inhibition of acetylcholine release from synaptosomes of colonic submucosal nerves...
  74. ncbi Roles of the telencephalic cells and their chondroitin sulfate proteoglycans in delimiting an anterior border of the retinal pathway
    H Ichijo
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Neurosci 21:9304-14. 2001
    ..The results indicate that the telencephalic cells delimit the anterior border of the optic tract with their CSPGs and prevent the retinal axons from aberrantly entering the anterior territory...
  75. ncbi Transdermal penetration of UV filters
    P Klinubol
    Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Skin Pharmacol Physiol 21:23-9. 2008
    ..The results also confirmed the significant penetrations of EHMC and BMBM and the insignificant penetrations of EHTMC and TMB...
  76. ncbi Mechanisms of chloride secretion induced by thermostable direct haemolysin of Vibrio parahaemolyticus in human colonic tissue and a human intestinal epithelial cell line
    A Takahashi
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Japan
    J Med Microbiol 49:801-10. 2000
    ..Thus, TDH increases Cl- secretion in human colonic epithelial cells, apparently through mechanisms involving cell binding and Ca2+ influx, followed by elevation of [Ca2+]in associated with PKC phosphorylation...
  77. ncbi Cryosurgery of normal and tumor tissue in the dorsal skin flap chamber: Part II--injury response
    N E Hoffmann
    Department of Biomedical Engineering, University of Minnesota, Minneapolis 55455, USA
    J Biomech Eng 123:310-6. 2001
    ..These results are consistent with the hypothesis that vascular-mediated injury is responsible for the majority of injury at the edge of the frozen region in microvascular perfused tissue...
  78. ncbi Anticoagulants (thrombin inhibitors) and aspirin synergize with P2Y12 receptor antagonism in thrombosis
    Patrick Andre
    Millennium Pharmaceuticals, Inc, 256 E Grand Ave, South San Francisco, Calif 9408, USA
    Circulation 108:2697-703. 2003
    ..This study was designed to determine whether (1) P2Y12 antagonism synergizes with other antithrombotics and (2) anticoagulants (thrombin inhibitors) affect the antithrombotic activity elicited by P2Y12 antagonism...
  79. ncbi Effect of electric field on the enhanced skin permeation of drugs by electroporation
    Kenji Mori
    Tsukuba Research Laboratories, Hisamitsu Pharmaceutical Co Ltd, 1 25 11 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Control Release 90:171-9. 2003
    ....
  80. ncbi Evaluation of barrier creams against sulphur mustard: (II) In vivo and in vitro studies using the domestic white pig
    Robert P Chilcott
    Chemical Hazards and Poisons Division, Health Protection Agency, Chilton, Didcot, Oxfordshire, United Kingdom
    Cutan Ocul Toxicol 26:235-47. 2007
    ..cm(-2), respectively), further validating the use of pigs as a toxicologically-relevant dermal model for SM exposure...
  81. ncbi GTX 2/3 epimers permeate the intestine through a paracellular pathway
    Rafael Torres
    Lab Bioquímica de Membrana, Dept de Fisiologia y Biofisica, Facultad de Medicina, Universidad de Chile, Casilla 70005, Correo 7, Santiago, Chile
    J Toxicol Sci 32:241-8. 2007
    ..A model was developed, according to which tight junctions undergo a toxin concentration and time-dependent change, while transepithelial resistance shows a modest decrease...
  82. ncbi Improved survival of macroencapsulated islets of Langerhans by preimplantation of the immunoisolating device: a morphometric study
    E Rafael
    Department of Transplantation Surgery, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Cell Transplant 12:407-12. 2003
    ..42 +/- 0.5 vs. 0.50 +/- 0.3). Preimplantation of the TheraCyte device seems to improve the survival of an encapsulated islet graft and reduce fibroblast outgrowth in the device...
  83. ncbi Applicability of the Ussing chamber technique to permeability determinations in functionally distinct regions of the gastrointestinal tract in the rat
    B H Bajka
    Child Health Research Institute and Cooperative Research Centre for Tissue Growth and Repair, Adelaide, South Australia, Australia
    Scand J Gastroenterol 38:732-41. 2003
    ..Ussing chambers are commonly utilized for in vitro investigations into gastrointestinal permeability. However, their sensitivity and applicability to the small intestine have not been well characterized...
  84. ncbi Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering
    Benedetto Manasseri
    Department of Surgical Specialties, Plastic Surgery Division, University of Messina Medical School, Messina, Italy
    Microsurgery 27:623-9. 2007
    ..Here we describe a new microsurgical model of bioengineering in rats based on the use of an arterovenous loop (AV) implanted into a commercially available crosslinked collagen/glycosaminoglycan template...
  85. pmc A novel human skin chamber model to study wound infection ex vivo
    Lars Steinstraesser
    Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Arch Dermatol Res 302:357-65. 2010
    ..For investigation of wound infection, treatment and healing, the BO-drum presents a convenient model and may help to standardize wound research...
  86. pmc In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum
    Henriette Baun Madsen
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark
    AAPS J 11:728-39. 2009
    ..The increased penetration seems to be reflected by a change in the intercellular space between the corneocytes, and the effect is most likely caused by the components of the ISCOMs rather than intact ISCOMs...
  87. ncbi The passage of trimethylamine across rat and human skin
    S Kenyon
    Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Food Chem Toxicol 42:1619-28. 2004
    ..Small but detectable amounts of trimethylamine were oxidised to its N-oxide during passage through the skin...
  88. ncbi A novel transdermal patch incorporating isosorbide dinitrate with bisoprolol: in vitro and in vivo characterization
    Ji Hui Zhao
    State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Int J Pharm 337:88-101. 2007
    ..As a patient-friendly, convenient, and multi-day dosing therapeutic system, the transdermal patches incorporating ISDN and BP could be promising for prevention and treatment of hypertension...
  89. ncbi Transdermal delivery of cytochrome C--A 12.4 kDa protein--across intact skin by constant-current iontophoresis
    J Cázares-Delgadillo
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, 30 Quai Ernest Ansermet, 1211, Geneva, Switzerland
    Pharm Res 24:1360-8. 2007
    ..To demonstrate the transdermal iontophoretic delivery of a small (12.4 kDa) protein across intact skin...
  90. ncbi Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines
    Yan Yu
    Orthopaedic Research Laboratory, University of New South Wales, The Prince of Wales Hospital, Sydney, NSW 2031, Australia
    J Biomed Mater Res A 70:122-8. 2004
    ..The characterized cell lines can be used as positive and negative controls for the assessments of both in vitro and in vivo bone formation capabilities of designed tissues or biomaterials...
  91. ncbi A new technique for measurement of water permeability of stomatous cuticular membranes isolated from Hedera helix leaves
    J Santrucek
    Institute of Plant Molecular Biology, AS CR, Branisovska 31, CZ 37005 Ceske Budejovice, Czech Republic
    J Exp Bot 55:1411-22. 2004
    ....
  92. ncbi Permeability of human amniotic membrane to ofloxacin in vitro
    Miklós D Resch
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
    Invest Ophthalmol Vis Sci 51:1024-7. 2010
    ..The aim of this study was to develop a model to investigate the permeability of the amniotic membrane (AM) to ofloxacin eye drops, a widely used topical antibiotic in ocular surface disease after AM transplantation...
  93. ncbi Solute transport in the deep and calcified zones of articular cartilage
    K P Arkill
    Biophysics Group, School of Physics, University of Exeter, UK
    Osteoarthritis Cartilage 16:708-14. 2008
    ..2) To investigate transport from the subchondral microcirculation into calcified cartilage in an intact perfused joint and the effects on transport of static loading...
  94. ncbi Acetabular revision using grafts and cages
    Allan E Gross
    University of Toronto, and Division of Orthopaedic Surgery, Mount Sinai Hospital, Ontario, Canada
    Am J Orthop (Belle Mead NJ) 31:213-5. 2002
    ..Approaches to acetabular revision based on this classification have resulted in good outcomes...
  95. ncbi Overexpression of the 18 kDa and 22/24 kDa FGF-2 isoforms results in differential drug resistance and amplification potential
    Germana Dini
    Department of Experimental Pathology and Oncology of Florence University, Florence, Italy
    J Cell Physiol 193:64-72. 2002
    ..Coexpression of all isoforms appears to be necessary to obtain cumulative effects and nuclear-targeted HMW FGF-2 has a pivotal role in such a cooperation...
  96. ncbi Analysis of single-cell differences by use of an on-chip microculture system and optical trapping
    Y Wakamoto
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan
    Fresenius J Anal Chem 371:276-81. 2001
    ..It should thus help in the clarification of heterogeneous phenomena, for example unequal cell division and cell differentiation...
  97. ncbi Evaluation of reaction of primate brain to grafted PC12 cells
    H Yoshida
    Department of Neurological Surgery, Okayama University Medical School, Okayama ken, Japan
    Cell Transplant 8:427-30. 1999
    ..These results indicate that encapsulated PC12 cell transplantation is an effective and safe strategy for the treatment of Parkinson's disease...
  98. ncbi Glass ring-wall sealing to prevent leakage from electrode culture chambers: a technical note
    E Marani
    Dept Physiology, LUMC, The Netherlands
    Arch Physiol Biochem 106:316-7. 1998
    ..Repeated rinsing with xylene and subsequently with hydrated steps of ethanol (100%-70%-30%) allows the ring-wall and chamber floor with its electrodes to be reused...
  99. ncbi HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system
    U Koedel
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    J Immunol 163:1237-45. 1999
    ....
  100. ncbi Pharmacodynamics, chiral pharmacokinetics and PK-PD modelling of ketoprofen in the goat
    A K Arifah
    The Royal Veterinary College, University of London, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 26:139-50. 2003
    ..These data illustrate for KTP shallow concentration-response relationships, probable nonselectivity of KTP for cyclooxygenase (COX)-1 and COX-2 inhibition and lack of measurable effect on components of inflammation...
  101. ncbi A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals
    H Frederick Frasch
    Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26508, USA
    Cutan Ocul Toxicol 28:107-13. 2009
    ..818 +/- 0.030) and the intercept close to 0 (-0.014 +/- 0.023 h), with r(2) = 0.994. These results suggest that HGP skin may serve as an excellent surrogate for human skin in in vitro dermal penetration studies...

Research Grants34

  1. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  2. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  3. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  4. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  5. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Electroporation and transcutaneous extraction of drugs
    SATHYANARAYANA MURTHY; Fiscal Year: 2006
    ..Further we also plan to correlate the time course of unbound ciprofloxacin in dermal ECF with that in synovial fluid determined by microdialysis in rat. [unreadable] [unreadable] [unreadable]..
  7. PH REGULATION IN VENTRICULAR CELLS
    KENNETH SPITZER; Fiscal Year: 2002
    ..The results of this project will yield new information concerning hormonal modulation of cardiac pHi control systems and the action of intracellular and intercellular H+ diffusion to dissipate regional pHi gradients. ..
  8. Protein Biomarkers of Drinking During Pregnancy
    DANIEL SAVAGE; Fiscal Year: 2006
    ..abstract_text> ..
  9. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2007
    ....
  10. CHLORIDE TRANSPORT IN HUMAN CILIARY EPITHELIUM
    Richard Crook; Fiscal Year: 2001
    ..He also proposes to test the hypothesis that other hormones known to either increase or decrease aqueous inflow might exert their effects through modulation of Na+, K+, Cl cotransport activity. ..
  11. Screening Putative Therapeutic Agents for Fetal Ethanol-Induced Learning Deficits
    DANIEL SAVAGE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Interaction between host cells and multicomponent material matrix
    WEIYUAN KAO; Fiscal Year: 2009
    ..e., human blood-derived macrophages, dermal fibroblasts, and keratinocytes) using monoculture and binary cell culture systems. (3) To ascertain IPN efficacy in vivo in modulating the host reaction and healing. ..
  13. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..
  14. In vivo study of diabetic hyperglycemia and inflammation
    Robert Gyurko; Fiscal Year: 2009
    ..Moreover, findings on novel lipid inhibitors of inflammation will be important in evaluating the therapeutic potential of these compounds in resolving inflammation in periodontal and other inflammations. ..
  15. NALTREXONE PRODRUGS FOR TRANSDERMAL DELIVERY
    Audra L Stinchcomb; Fiscal Year: 2010
    ....
  16. Dual Oxidase in Lung Epithelium
    HORST B FISCHER; Fiscal Year: 2011
    ..This research investigates a novel area of lung anti-microbial defense and will provide new information that may lead to therapeutic application. ..
  17. NOX-mediated proton secretion by airways
    Horst Fischer; Fiscal Year: 2006
    ..This will help develop novel therapeutical targets for the treatment of airway acidity and inflammatory airway diseases. ..
  18. Glial Maintenance of Local K+ and Neurotransmission
    JULIAN MEEKS; Fiscal Year: 2005
    ..These studies will determine the functional relevance of KIRs in hippocampal astrocytes and provide new insight into the role of KIRs in passive [K+]o buffering. ..
  19. MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
    Anthony Blikslager; Fiscal Year: 2002
    ..These experiments will provide insight into the signaling pathways and mechanisms by which prostaglandins trigger repair of acutely-injured intestinal epithelium. ..
  20. ARNDS--CORTICAL PLASTICITY AND LEARNING
    DANIEL SAVAGE; Fiscal Year: 2002
    ..Such information can show the way to preventing life-long cognitive and behavioral handicaps. ..
  21. TECNIA 12 BioTWIN Transmission Electron Microscope
    Guido Zampighi; Fiscal Year: 2003
    ..abstract_text> ..
  22. A Method To Study Membrane Protein Structure
    Guido Zampighi; Fiscal Year: 2003
    ....
  23. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2003
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  24. 3D Adipose Tissue Generation and Functional Verification
    Charles Patrick; Fiscal Year: 2004
    ..abstract_text> ..
  25. VASCULARIZATION IN TISSUE ENGINEERED CONSTRUCTS
    Charles Patrick; Fiscal Year: 2001
    ..does TEC-recipient inosculation play in TEC vascularization? (b) What are the biological functions of CD144, principally with regards to its role in inosculation and its regulation by the unique TEC microenvironment? ..
  26. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2001
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  27. MECHANISMS OF ARND RELATED SYNAPTIC PLASTICITY DEFICITS
    DANIEL SAVAGE; Fiscal Year: 2002
    ..Further, these results could provide insights into whether agents that affect mGluR function could be used to treat synaptic plasticity deficits and, ultimately, learning deficits in prenatal ethanol-exposed offspring. ..
  28. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ....
  29. Estrogen: Chrodroprotective or Destructive?
    Sally Frenkel; Fiscal Year: 2002
    ..The inconclusive and contradictory data from human and animal studies render the proposed studies highly significant. ..
  30. SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURY
    Martin Marsala; Fiscal Year: 2001
    ..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
  31. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....
  32. PATHOGENESIS OF CORNEAL EDEMA AFTER INTRAOCULAR SURGERY
    Henry Edelhauser; Fiscal Year: 2006
    ....
  33. Transdermal Codrugs for Treatment of Alcoholism
    Audra Stinchcomb; Fiscal Year: 2006
    ..Correlation of the in vitro data with the in vivo model will aid in the creation of a reliable QSAR database that is necessary to help identify the best co-drugs for clinical use. ..
  34. Nitric Oxide Defense Against Porphyromonas gingivalis
    Robert Gyurko; Fiscal Year: 2006
    ..He is applying for the NIDCR Scholar Development and Faculty Transition Award to pursue scientific career as an independent investigator at Boston University School of Dental Medicine. [unreadable] [unreadable]..