body surface area

Summary

Top Publications

  1. ncbi The 3D scanner for measuring body surface area: a simplified calculation in the Chinese adult
    Chi Yuan Yu
    Department of Industrial Engineering and Engineering Management, National Tsing Hua University, Shinchu, Taiwan, ROC
    Appl Ergon 34:273-8. 2003
  2. ncbi A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate
    Guy Rostoker
    Unit of Nephrology and Dialysis, Centre Hospitalier Prive Claude Galien, Quincy sous Senart France
    J Nephrol 20:576-85. 2007
  3. doi Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area
    Arik Wolak
    Departments of Imaging, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California at Los Angeles, USA
    JACC Cardiovasc Imaging 1:200-9. 2008
  4. ncbi Factors affecting epirubicin pharmacokinetics and toxicity: evidence against using body-surface area for dose calculation
    H P Gurney
    Department of Medical Oncology and Palliative Care, Westmead Hospital, Australia
    J Clin Oncol 16:2299-304. 1998
  5. ncbi Flat-fixed dosing of irinotecan: influence on pharmacokinetic and pharmacodynamic variability
    Floris A de Jong
    Department of Medical Oncology, Erasmus University MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Cancer Res 10:4068-71. 2004
  6. ncbi Human body surface area: measurement and prediction using three dimensional body scans
    P Tikuisis
    Defence and Civil Institute of Environmental Medicine, Human Protection and Performance, 1133 Sheppard Avenue West, PO Box 2000, Toronto, Ontario, Canada M3M 3B9
    Eur J Appl Physiol 85:264-71. 2001
  7. doi The Self-administered Eczema Area and Severity Index in children with moderate to severe atopic dermatitis: better estimation of AD body surface area than severity
    Sara G A Van Velsen
    Department of Pediatric Dermatology Allergology, Wilhelmina s Children Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Pediatr Dermatol 27:470-5. 2010
  8. doi Valganciclovir dosing according to body surface area and renal function in pediatric solid organ transplant recipients
    W Vaudry
    Stollery Children s Hospital, University of Alberta, Edmonton, Canada
    Am J Transplant 9:636-43. 2009
  9. doi Validation of a new contrast material protocol adapted to body surface area for optimized low-dose CT coronary angiography with prospective ECG-triggering
    Aju P Pazhenkottil
    Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Int J Cardiovasc Imaging 26:591-7. 2010
  10. pmc How to calculate the dose of chemotherapy
    Howard Gurney
    Department of Medical Oncology and Palliative Care, Westmead Hospital, Westmead 2145, Australia
    Br J Cancer 86:1297-302. 2002

Detail Information

Publications275 found, 100 shown here

  1. ncbi The 3D scanner for measuring body surface area: a simplified calculation in the Chinese adult
    Chi Yuan Yu
    Department of Industrial Engineering and Engineering Management, National Tsing Hua University, Shinchu, Taiwan, ROC
    Appl Ergon 34:273-8. 2003
    ..A model is presented for estimation of human body surface area (BSA), which is identical in form to the one proposed in 1916 by DuBois and DuBois is presented...
  2. ncbi A modified Cockcroft-Gault formula taking into account the body surface area gives a more accurate estimation of the glomerular filtration rate
    Guy Rostoker
    Unit of Nephrology and Dialysis, Centre Hospitalier Prive Claude Galien, Quincy sous Senart France
    J Nephrol 20:576-85. 2007
    We sought to validate the improvement by adjustment for body surface area (BSA) of the accuracy of the original Cockcroft-Gault equation to estimate glomerular filtration rate (GFR), in a prospective cross-sectional study of 269 European ..
  3. doi Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area
    Arik Wolak
    Departments of Imaging, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California at Los Angeles, USA
    JACC Cardiovasc Imaging 1:200-9. 2008
    ..To determine normal limits for ascending and descending thoracic aorta diameters in a large population of asymptomatic, low-risk adult subjects...
  4. ncbi Factors affecting epirubicin pharmacokinetics and toxicity: evidence against using body-surface area for dose calculation
    H P Gurney
    Department of Medical Oncology and Palliative Care, Westmead Hospital, Australia
    J Clin Oncol 16:2299-304. 1998
    ..An exploratory study to test whether body-surface area (BSA) should be used for the calculation of epirubicin dose...
  5. ncbi Flat-fixed dosing of irinotecan: influence on pharmacokinetic and pharmacodynamic variability
    Floris A de Jong
    Department of Medical Oncology, Erasmus University MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Cancer Res 10:4068-71. 2004
    ..Here, we prospectively evaluated the effects of administering a flat-fixed irinotecan dose to cancer patients, regardless of BSA...
  6. ncbi Human body surface area: measurement and prediction using three dimensional body scans
    P Tikuisis
    Defence and Civil Institute of Environmental Medicine, Human Protection and Performance, 1133 Sheppard Avenue West, PO Box 2000, Toronto, Ontario, Canada M3M 3B9
    Eur J Appl Physiol 85:264-71. 2001
    ..graphics editing software have allowed an alternative and potentially more accurate determination of body surface area (BSA)...
  7. doi The Self-administered Eczema Area and Severity Index in children with moderate to severe atopic dermatitis: better estimation of AD body surface area than severity
    Sara G A Van Velsen
    Department of Pediatric Dermatology Allergology, Wilhelmina s Children Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Pediatr Dermatol 27:470-5. 2010
    ..61, p = <0.001), mainly based on high correlation between the body surface area (BSA) measurements of both scores (ρ = 0.50, p = <0.001)...
  8. doi Valganciclovir dosing according to body surface area and renal function in pediatric solid organ transplant recipients
    W Vaudry
    Stollery Children s Hospital, University of Alberta, Edmonton, Canada
    Am J Transplant 9:636-43. 2009
    ..up to 100 days' valganciclovir prophylaxis; dosage was calculated using the algorithm: dose (mg) = 7 x body surface area x creatinine clearance (Schwartz method; CrCLS)...
  9. doi Validation of a new contrast material protocol adapted to body surface area for optimized low-dose CT coronary angiography with prospective ECG-triggering
    Aju P Pazhenkottil
    Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Int J Cardiovasc Imaging 26:591-7. 2010
    ..As increased blood volume is well paralleled by body surface area (BSA) we assessed a BSA-adapted CM protocol to compensate for dilution effects...
  10. pmc How to calculate the dose of chemotherapy
    Howard Gurney
    Department of Medical Oncology and Palliative Care, Westmead Hospital, Westmead 2145, Australia
    Br J Cancer 86:1297-302. 2002
    b>Body surface area-dosing does not account for the complex processes of cytotoxic drug elimination. This leads to an unpredictable variation in effect...
  11. ncbi Indexing glomerular filtration rate for body surface area in obese patients is misleading: concept and example
    Pierre Delanaye
    Nephrol Dial Transplant 20:2024-8. 2005
  12. doi Contrast enhancement in cardiovascular MDCT: effect of body weight, height, body surface area, body mass index, and obesity
    Kyongtae T Bae
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Ste 4895, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 190:777-84. 2008
    The purpose of our study was to evaluate the effect of body weight, height, body surface area (BSA), body mass index (BMI), and obesity on aortic contrast enhancement in cardiac MDCT.
  13. ncbi Flat-fixed dosing versus body surface area based dosing of anticancer drugs in adults: does it make a difference?
    Ron H J Mathijssen
    Erasmus University Medical Center Rotterdam Daniel den Hoed Cancer Center, Department of Medical Oncology, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Oncologist 12:913-23. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  14. doi Waist circumference and waist/hip ratio are better predictive risk factors for mortality and morbidity after colorectal surgery than body mass index and body surface area
    Alex H Kartheuser
    Colorectal Surgery Unit and Colorectal Tumor Board, Cliniques Universitaires Saint Luc, Brussels, Belgium Department of Abdominal Surgery, Gasthuisberg University Hospital, Leuven, Belgium Department of Coloproctology, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom Department of Digestive Surgery, Hopital St Joseph, Gilly, Belgium Plateforme technologique de Support en Méthodologie et Calcul Statistique, Universite Catholique de Louvain, Louvain la Neuve, Belgium Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA Department of Colorectal Surgery, Oxford University Hospitals, Oxford, United Kingdom Service of Visceral Surgery, Geneva University Hospitals, Geneva, Switzerland Department of General and Digestive Surgery, Hopital St Antoine, Paris, France
    Ann Surg 258:722-30. 2013
    To determine whether body fat distribution, measured by waist circumference (WC) and waist/hip ratio (WHR), is a better predictor of mortality and morbidity after colorectal surgery than body mass index (BMI) or body surface area (BSA).
  15. doi Body surface area index predicts outcome in orthotopic liver transplantation
    Kyota Fukazawa
    Division of Solid Organ Transplantation, Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami, Leonard Miller School of Medicine, 1611 NW 12th Avenue, D318, Miami, FL 33136, USA
    J Hepatobiliary Pancreat Sci 18:216-25. 2011
    ..We sought to determine whether a new parameter, the ratio of donor to recipient body surface area (BSAi), is predictive of size mismatch and/or post-transplant morbidity or mortality.
  16. doi Drug dosing based on weight and body surface area: mathematical assumptions and limitations in obese adults
    Manjunath P Pai
    Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York 12186, USA
    Pharmacotherapy 32:856-68. 2012
    ..Drugs are generally dosed according to one of three approaches: fixed dosing, weight-based dosing, or body surface area-based dosing...
  17. doi Pooled analysis of two case-control studies in New Caledonia and French Polynesia of body mass index and differentiated thyroid cancer: the importance of body surface area
    Enora Clero
    Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, U1018 Inserm, Villejuif, France
    Thyroid 20:1285-93. 2010
    ..In this study we evaluated further the relationship between body mass index (BMI) and other anthropometric parameters on the incidence of thyroid cancer in the New Caledonia and French Polynesia populations...
  18. doi Prednisone dosing per body weight or body surface area in children with nephrotic syndrome: is it equivalent?
    Janusz Feber
    Department of Pediatrics, Division of Nephrology, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada
    Pediatr Nephrol 24:1027-31. 2009
    The current guidelines recommend a dosage of prednisone of 60 mg/m(2) body surface area per day (BSA PRED) for the initial therapy of nephrotic syndrome (NS). Alternatively, a dosage of 2 mg/kg body weight per day (W PRED) can be used...
  19. doi Indexation of left ventricular mass to body surface area and height to allometric power of 2.7: is the difference limited to obese hypertensives?
    C Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hum Hypertens 23:728-34. 2009
    ..7) in women. Overall, 687 out of 2213 patients (31.0%) were found to have LVH when LVM was indexed to body surface area (BSA) and 1030 (46.5%) when indexed to height(2.7). A total of 845 patients (38...
  20. ncbi [The results of thyroid ultrasound examination in randomly selected schoolchildren]
    Narseta Mickuviene
    Institute of Endocrinology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 42:751-8. 2006
    ..Iodine deficiency is an actual problem of public health and mostly manifests as enlargement of the thyroid (goiter)...
  21. ncbi Energy requirements and body surface area of cats and dogs
    Richard C Hill
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0126, USA
    J Am Vet Med Assoc 225:689-94. 2004
  22. ncbi Effects of body surface area estimates on predicted energy requirements and heat stress
    A Berman
    Department of Animal Science, Hebrew University, Rehovot 76100, Israel
    J Dairy Sci 86:3605-10. 2003
    The 0.09 x W(0.67) equation (where W = weight in kilograms) used to estimate body surface area (SA) in cattle energy requirements models was developed using measurements of sheep that weighed between 24 and 38 kg...
  23. doi Determination of the safe range of graft size mismatch using body surface area index in deceased liver transplantation
    Kyota Fukazawa
    Division of Solid Organ Transplantation, Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, FL 33136, USA
    Transpl Int 26:724-33. 2013
    ..We developed a multivariate survival model (generalized additive model) to estimate hazard risk of body surface area index (BSAi) for 3-year graft survival using data derived from the national registry database between 2005 ..
  24. pmc Body surface area estimation in children using weight alone: application in paediatric oncology
    I Sharkey
    Pharmacy Dept, Royal Victoria Infirmary, Newcastle, UK
    Br J Cancer 85:23-8. 2001
    The majority of chemotherapy regimens and trials specify doses of cytotoxic drugs normalized to body surface area. Estimation of BSA in paediatric patients is particularly problematic, as conventional nomograms require accurate ..
  25. doi Lean body mass is better than body surface area in correcting GFR
    Hongwei Si
    Department of Nuclear Medicine, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China
    Clin Nucl Med 38:e210-5. 2013
    The Gates-based renography (gGFR) and plasma-based clearance rate (pGFR) are conventionally corrected with body surface area (BSA). Limited studies indicated that the lean body mass (LBM) might be better than BSA in correcting pGFR...
  26. pmc Dialysis dose scaled to body surface area and size-adjusted, sex-specific patient mortality
    Sylvia Paz B Ramirez
    Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA
    Clin J Am Soc Nephrol 7:1977-87. 2012
    ..This study sought to determine whether rescaling dose to body surface area (SA) might reveal different associations among dose, sex, and mortality.
  27. pmc Reliability, validity and responsiveness to change of the Patient Report of Extent of Psoriasis Involvement (PREPI) for measuring body surface area affected by psoriasis
    E D Dommasch
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Br J Dermatol 162:835-42. 2010
    ..The development of a simple, reliable, valid and responsive method for measuring the extent of skin involvement in psoriasis is important for use in epidemiological studies...
  28. ncbi Determination of body surface area and formulas to estimate body surface area using the alginate method
    Joo Young Lee
    Laboratory for Health and Human Performance in Extreme Environments LHHPEE, Department of Integrative Biology and Physiology, Medical School, University of Minnesota, USA
    J Physiol Anthropol 27:71-82. 2008
    The purpose of this study was to determine the body surface area (BSA) based on the alginate method, to derive formulae for estimating BSA, and to compare the error of the present formula to previous formulas obtained from other ..
  29. doi Prophylactic aortic root surgery in patients with Marfan syndrome: 10 years' experience with a protocol based on body surface area
    Jan J J Aalberts
    Department of Cardiothoracic Surgery, University Medical Center Groningen, The Netherlands
    Eur J Cardiothorac Surg 34:589-94. 2008
    ..However, aortic root diameter is a function of body surface area (BSA). Here, we report our experience with a protocol for prophylactic aortic root replacement based on BSA.
  30. doi Clinical implications of the body surface area method versus partition model dosimetry for yttrium-90 radioembolization using resin microspheres: a technical review
    Yung Hsiang Kao
    Department of Nuclear Medicine and PET, Singapore General Hospital
    Ann Nucl Med 25:455-61. 2011
    ..For resin microspheres, the 'body surface area (BSA)' method and the partition model can both be used for Y-90 activity calculation...
  31. ncbi The origin of the 1 x 73-m2 body surface area normalization: problems and implications
    James G Heaf
    Department of Nephrology B, Copenhagen University Hospital, Herlev, Denmark
    Clin Physiol Funct Imaging 27:135-7. 2007
    A historical review of the origins of body surface area (BSA) determination reveals a number of theoretical and methodological errors, as does the choice of 1 x 73 m(2) as the normal BSA for humans...
  32. doi Interdependence between body surface area and ultraviolet B dose in vitamin D production: a randomized controlled trial
    M K B Bogh
    Department of Dermatology, Copenhagen University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
    Br J Dermatol 164:163-9. 2011
    Ultraviolet (UV) B radiation increases serum vitamin D level expressed as 25-hydroxyvitamin-D(3) [25(OH)D], but the relationship to body surface area and UVB dose needs investigation.
  33. pmc Can rescaling dose of dialysis to body surface area in the HEMO study explain the different responses to dose in women versus men?
    John T Daugirdas
    Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 7323, USA
    Clin J Am Soc Nephrol 5:1628-36. 2010
    ....
  34. ncbi The online measurement of hemodialysis dose (Kt): clinical outcome as a function of body surface area
    Edmund G Lowrie
    Health Information Systems, Fresenius Medical Care North America, Lexington, Massachusetts 02420 9192, USA
    Kidney Int 68:1344-54. 2005
    ..Average Kecn and treatment length, t, are multiplied giving total clearance, Kt. The body surface area (BSA) is a fixed transformation of height and weight and is a well recognized measure of body size...
  35. doi Doppler assessment of the ratio of the systolic to diastolic duration in normal children: relation to heart rate, age and body surface area
    Roberto Sarnari
    Pediatric Echocardiography, Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Stanford, CA, USA
    J Am Soc Echocardiogr 22:928-32. 2009
    ..The purposes of this study were to establish normal values for the S/D ratio in children without heart disease and to investigate its variation with heart rate (HR), age, and body surface area.
  36. ncbi Determination of height, weight, body mass index, and body surface area with a single abdominal CT image
    Estella M Geraghty
    Department of Radiology, University of California Davis Medical Center, 4701 X St, Sacramento, CA 95817 2205, USA
    Radiology 228:857-63. 2003
    Techniques for estimation of an individual's height, weight, body mass index (BMI), and body surface area (BSA) with a single abdominal computed tomographic (CT) image were developed...
  37. ncbi Scaling cardiac structural data by body dimensions: a review of theory, practice, and problems
    A M Batterham
    University of Teesside, Middlesbrough, UK
    Int J Sports Med 20:495-502. 1999
    ..of cardiac dimensions has been performed typically via a per-ratio standards method, (Y/X), with body surface area chosen as the size denominator...
  38. doi Height, whole Body Surface Area, gender, working outdoors, and sunbathing in previous summer are important determinants of serum 25-hydroxyvitamin D levels
    K Pazaitou-Panayiotou
    Department of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece
    Exp Clin Endocrinol Diabetes 120:14-22. 2012
    To investigate if serum 25-hydroxyvitamin D (25(OH)D) is related to the whole Body Surface Area (BSA), and to several other anthropometric and environmental factors.
  39. doi Assessment of left and right ventricular parameters in healthy Korean volunteers using cardiac magnetic resonance imaging: change in ventricular volume and function based on age, gender and body surface area
    Sung A Chang
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Int J Cardiovasc Imaging 28:141-7. 2012
    ..All parameters were analyzed based on age and gender, and normalized to body surface area (BSA). LV volume, mass and cardiac output were significantly greater in males than in females...
  40. doi Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes
    J Rawlins
    King s College Hospital, London, United Kingdom
    Circulation 121:1078-85. 2010
    ..There are no reports on cardiac adaptation in highly trained black females, who comprise an increasing population of elite competitors...
  41. doi Gender, age, and body surface area are the major determinants of ascending aorta dimensions in subjects with apparently normal echocardiograms
    Patric Biaggi
    Cardiovascular Center, Department of Cardiology, University Hospital of Zurich, Zurich, Switzerland
    J Am Soc Echocardiogr 22:720-5. 2009
    ..Limited data have been published on the normal size of the ascending aorta (AA) measured using transthoracic echocardiography (TTE)...
  42. pmc Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance
    Alicia M Maceira
    Cardiac Imaging Unit, ERESA, Valencia, Spain
    J Cardiovasc Magn Reson 12:65. 2010
    ..We used SSFP cines to define normal ranges for LA volumes and dimensions relative to gender, age and body surface area (BSA), and examine the relative value of 2D atrial imaging techniques in patients...
  43. pmc In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury
    Maria Louisa Izamis
    The Center for Engineering in Medicine, Massachusetts General Hospital Harvard Medical School Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
    Biotechnol Bioeng 108:839-52. 2011
    ..Rats received a sham (control uninjured), 20% or 40% total body surface area (TBSA) scald burn, and were allowed to develop a hypermetabolic response...
  44. pmc Normal values of aortic dimensions, distensibility, and pulse wave velocity in children and young adults: a cross-sectional study
    Inga Voges
    Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig Holstein, Campus Kiel, Arnold Heller Str, 3, 24105, Kiel, Germany
    J Cardiovasc Magn Reson 14:77. 2012
    ..However, normal CMR values for healthy children and young adults are lacking...
  45. doi Analysis of past and present methods of measuring and estimating body surface area and the resulting evaluation of its doubtful suitability to universal application
    Giancarlo Ruggieri
    Centro di Nefrologia e Dialisi, Ospedale San Giacomo, Rome, Italy
    Blood Purif 30:296-305. 2010
    b>Body surface area (BSA) is probably the most used tool for indexing physiological functions...
  46. ncbi Body surface area in normal-weight, overweight, and obese adults. A comparison study
    Johan Verbraecken
    Department of Pulmonary Medicine, University Hospital Antwerp, 2650 Edegem, Belgium
    Metabolism 55:515-24. 2006
    Values for body surface area (BSA) are commonly used in medicine, particularly to calculate doses of chemotherapeutic agents and index cardiac output. Various BSA formulas have been developed over the years...
  47. doi Indexing of renal function parameters by body surface area: intelligence or folly?
    Pierre Delanaye
    Department of Nephrology Dialysis, University of Liege, CHU Sart Tilman, Liege, Belgium
    Nephron Clin Pract 119:c289-92. 2011
    Indexation of glomerular filtration rate (GFR) by body surface area (BSA) is often done without raising any questions...
  48. ncbi Distribution of Buruli ulcer lesions over body surface area in a large case series in Ghana: uncovering clues for mode of transmission
    Ilona C Hospers
    Department of Internal Medicine, Groningen University Medical Centre, P O Box 30001, 9700 RB Groningen, The Netherlands
    Trans R Soc Trop Med Hyg 99:196-201. 2005
    ..and lower extremities were affected equally by Buruli ulcers, if correction was made for differences in body surface area. Patients from outside the Amansie West district presented significantly more often with ulcerated lesions, ..
  49. pmc Normal values for aortic diameters in children and adolescents--assessment in vivo by contrast-enhanced CMR-angiography
    Thomas Kaiser
    Division of Pediatric Cardiology, University Children s Hospital, Zurich, Switzerland
    J Cardiovasc Magn Reson 10:56. 2008
    ..We sought to establish normal values for the diameters of the thoracic aorta and reference curves related to body growth in children using CE-CMRA...
  50. ncbi Chemotherapy dosing part I: scientific basis for current practice and use of body surface area
    S A Kaestner
    Department of Pharmacy and Pharmacology, 5W, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Clin Oncol (R Coll Radiol) 19:23-37. 2007
    ..In an attempt to reduce this variability, most chemotherapy doses are individualised according to patient body surface area (BSA)...
  51. ncbi Thyroid ultrasound is the best prevalence indicator for assessment of iodine deficiency disorders: a study in rural/tribal schoolchildren from Gujarat (Western India)
    S Brahmbhatt
    Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, Australia
    Eur J Endocrinol 143:37-46. 2000
    ....
  52. ncbi Body surface area in dosing anticancer agents: scratch the surface!
    Antonius A Miller
    J Natl Cancer Inst 94:1822-3. 2002
  53. ncbi Right ventricular Tei index in children: effect of method, age, body surface area, and heart rate
    David A Roberson
    Heart Institute for Children, Hope Children s Hospital, Oak Lawn, Illinois 60453, USA
    J Am Soc Echocardiogr 20:764-70. 2007
    ..the effects of the methods of Doppler tissue imaging (DTI) versus pulse wave Doppler (PWD) and age, body surface area (BSA), and heart rate on the RVTX in a population of 308 children with normal echocardiogram findings...
  54. ncbi Reduced dose of imatinib for patients with chronic myeloid leukemia and low body surface area
    Seh Jong Park
    Department of Internal Medicine, Division of Hematology Oncology, College of Medicine, Korea University, Seoul, Korea
    Acta Haematol 118:219-21. 2007
  55. doi Body surface area prediction in normal, hypermuscular, and obese mice
    Michael C Cheung
    Division of Surgical Oncology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Surg Res 153:326-31. 2009
    Accurate determination of body surface area (BSA) in experimental animals is essential for modeling effects of burn injury or drug metabolism...
  56. doi Surface cooling for rapid induction of mild hypothermia after cardiac arrest: design determines efficacy
    Thomas Uray
    Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
    Acad Emerg Med 17:360-7. 2010
    ..Recently, a novel cooling pad was developed for rapid induction of mild hypothermia after cardiac arrest. The aim of this study was to evaluate the cooling efficacy of three different pad designs for in-hospital cooling...
  57. ncbi Reduced nephron number and glomerulomegaly in Australian Aborigines: a group at high risk for renal disease and hypertension
    W E Hoy
    Centre for Chronic Disease, Central Clinical School University of Queensland, Brisbane, Queensland, Australia
    Kidney Int 70:104-10. 2006
    ..Optimization of fetal growth should ultimately reduce the florid epidemic of renal disease, hypertension, and cardiovascular disease...
  58. pmc The risk of thrombo-embolic events is increased in patients with germ-cell tumours and can be predicted by serum lactate dehydrogenase and body surface area
    A C Piketty
    Institut Gustave Roussy, Villejuif, France
    Br J Cancer 93:909-14. 2005
    ..In multivariate analysis, two factors had independent predictive value for TEE: a high body surface area (>1.9 m2) (RR: 5 (1.8-13.9)) and an elevated serum lactate dehydrogenase (LDH) (RR: 6.4 (2.3-18.2))...
  59. ncbi Effect of obesity on the leukocyte nadir in women treated with adjuvant cyclophosphamide, methotrexate, and fluorouracil dosed according to body surface area
    P Poikonen
    Department of Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 40:67-71. 2001
    ..the effect of parameters reflecting the body size, body weight and height, body mass index (BMI), and body surface area (BSA) on the depth of the blood leukocyte nadir in breast cancer patients receiving adjuvant chemotherapy, ..
  60. doi Management of burns of over 80% of total body surface area: a comparative study
    Feng Guo
    Department of Burns, First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui 230022, PR China
    Burns 35:210-4. 2009
    ..Over 1987-1996, 24 people with burns >80% of total body surface area and >50% full-thickness burn were admitted to the burn unit of Anhui Medical University Hospital (group A)..
  61. ncbi Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative
    H Gurney
    Department of Medical Oncology and Palliative Care, Westmead Hospital, Westmead, NSW, Australia
    J Clin Oncol 14:2590-611. 1996
    ..To review the current dose-calculation practice and propose a non-body-surface area (BSA)-based dose-calculation method...
  62. ncbi Body-surface area-based dosing does not increase accuracy of predicting cisplatin exposure
    F E de Jongh
    Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek, Rotterdam, The Netherlands
    J Clin Oncol 19:3733-9. 2001
    ..30% to 32.7%). CONCLUSION: In view of the high interpatient variability in CL(free) relative to variation in observed BSA, no rationale for continuing BSA-based dosing was found. We recommend fixed-dosing regimens for cisplatin...
  63. ncbi Annular and septal Doppler tissue imaging in children: normal z-score tables and effects of age, heart rate, and body surface area
    David A Roberson
    Heart Institute for Children, Oaklawn, Illinois 60453, USA
    J Am Soc Echocardiogr 20:1276-84. 2007
    ..normal echocardiograms from 634 children aged 1 day to 18 years, heart rate (HR) range of 50 to 194/min, and body surface area (BSA) range of 0.1 to 2.8 m2...
  64. ncbi Standardization of the body surface area (BSA) formula to calculate the dose of anticancer agents in Japan
    Tsutomu Kouno
    Department of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 33:309-13. 2003
    The importance of deciding the appropriate dose of anticancer agents cannot be overemphasized. Body surface area (BSA) has been used to calculate the dose in anticancer therapy since the 1950s...
  65. ncbi Determination of normal gender-specific left atrial dimensions by cardiovascular magnetic resonance imaging
    Burkhard Sievers
    Department of Cardiology and Angiology, Marienhospital, University of Bochum, Herne, Germany
    J Cardiovasc Magn Reson 7:677-83. 2005
    ..We aimed to establish normal values for LAEDD using CMR and a fast gradient-echo sequence with steady-state free precession (SSFP)...
  66. ncbi Adequacy of peritoneal dialysis in children: consider the membrane for optimal prescription
    Michel Fischbach
    Nephrology Dialysis and Transplantation Children s Unit, University Hospital, University Louis Pasteur, Strasbourg, France
    Perit Dial Int 27:S167-70. 2007
    ..Fill volume should be scaled for body surface area (mL/m2) and, to avoid a hyperpermeable exchange, for a not-too-small amount...
  67. ncbi Flat-fixed dosing versus body surface area based dosing of anticancer drugs: there is a difference
    Georg Hempel
    Institut für Pharmazeutische und Medizinische Chemie Klinische Pharmazie Hittorfstr 58 62, 48149 Munster, Germany
    Oncologist 12:924-6. 2007
  68. ncbi Anthropometric prediction of total body water in children who are on pediatric peritoneal dialysis
    Bruce Z Morgenstern
    Division of Pediatric Nephrology, Phoenix Children s Hospital, 1919 East Thomas Road, Phoenix, AZ 85016, USA
    J Am Soc Nephrol 17:285-93. 2006
    ..37 x weight; for girls, TBW = 0.14 x (HtWt)0.64 - 0.35 x weight. The height x weight parameter also predicts body surface area (BSA). These equations can be simplified, with slightly less precision, to the following: For boys, TBW = 20...
  69. ncbi Evaluation of an alternate dosing strategy for cisplatin in patients with extreme body surface area values
    Walter J Loos
    Department of Medical Oncology, Erasmus MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 24:1499-506. 2006
    The majority of cytotoxic drugs for adults are dosed based on body surface area (BSA), aiming to reduce interpatient variability in drug exposure...
  70. ncbi Systolic and diastolic time intervals measured from Doppler tissue imaging: normal values and Z-score tables, and effects of age, heart rate, and body surface area
    Wei Cui
    Heart Institute for Children, Oaklawn, Oaklawn, Illinois 60453, USA
    J Am Soc Echocardiogr 21:361-70. 2008
    ..intervals measured by Doppler tissue imaging (DTI) and to determine the effects of age, heart rate (HR), and body surface area on DTI-derived time intervals in children. We studied 593 children with normal echocardiogram results...
  71. ncbi Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001
    Sharyn D Baker
    Division of Experimental Therapeutics, The Sydney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21237, USA
    J Natl Cancer Inst 94:1883-8. 2002
    The prescribed dose of anticancer agents is most commonly calculated using body surface area as the only independent variable, and it has been shown that this approach still results in large interpatient variability in drug exposure...
  72. ncbi Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhythmias in Brugada syndrome
    Lars Eckardt
    Hospital of the Westfälischen Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Electrophysiol 13:742-9. 2002
    ..Therefore, the body surface area of ST elevation and the presence of late potentials were compared to the inducibility of VT in patients with ..
  73. ncbi Body surface area as a determinant of pharmacokinetics and drug dosing
    M Sawyer
    Committee on Clinical Pharmacology, Department of Medicine, and Cancer Research Center, The University of Chicago, 60637-1470, IL, USA
    Invest New Drugs 19:171-7. 2001
    b>Body surface area (BSA) was introduced into medical oncology in order to derive a safe starting dose for phase I studies of anticancer drugs from preclinical animal toxicology data...
  74. ncbi A review of computer-aided body surface area determination: SAGE II and EPRI's 3D Burn Vision
    J M Neuwalder
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Burn Care Rehabil 23:55-9; discussion 54. 2002
    Estimates of percent body surface area (%BSA) burns correlate well with fluid needs, nutritional requirements, and prognosis. Most burn centers rely on the Lund Browder chart and "rule of nines," to calculate the %BSA...
  75. ncbi Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration
    Giovanni Vitale
    Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, 80127 Napoli, Italy
    J Clin Endocrinol Metab 88:1319-22. 2003
    ..of several demographic and anthropometric parameters [age, body weight, height, body mass index, and body surface area (BSA)] on serum peak TSH levels after rhTSH administration...
  76. ncbi The natural history of the growth of the hand: I. Hand area as a percentage of body surface area
    H R Amirsheybani
    Department of Surgery, the Pinnacle Health System, Department of Psychiatry, University of California at Los Angeles, USA
    Plast Reconstr Surg 107:726-33. 2001
    ..The area of the palmar surface of one hand has been estimated to be 1 percent of the body surface area. The area of the palmar surface of the hand was measured to test the accuracy of this estimate and then ..
  77. doi Dose standardisation of anticancer drugs
    Anne Lise Pouliquen
    Pharmacy Department, Hopital Saint Louis, AP HP, Paris, France
    Int J Clin Pharm 33:221-8. 2011
    ..Dose standardisation is a first step in order to rationalise chemotherapy dose calculation. A new method, derived from dose-banding, was developed, taking into account prescription and economic criteria...
  78. ncbi Combination vinorelbine and capecitabine for metastatic breast cancer using a non-body surface area dosing scheme
    Anne F Schott
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Cancer Chemother Pharmacol 58:129-35. 2006
    ..A flat dosing scheme of both drugs was used to facilitate development of the oral regimen, and because neither drug's clearance is associated with body surface area (BSA), pharmacokinetic and pharmacogenetic endpoints were explored.
  79. ncbi Low birth weight and reduced renal volume in Aboriginal children
    J Spencer
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Am J Kidney Dis 37:915-20. 2001
    ..523. Combined kidney volume, corrected for body surface area (corrKV), was independent of age and averaged 240 +/- 45 mL/1.73 m(2)...
  80. doi Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia
    Tatsuya Kawaguchi
    Department of Hematology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan
    Int J Hematol 89:642-8. 2009
    ..b>Body surface area (BSA) was significantly smaller in patients receiving the reduced dose compared with those receiving the ..
  81. pmc Dose of dialysis based on body surface area is markedly less in younger children than in older adolescents
    John T Daugirdas
    University of Illinois at Chicago, 820 S Wood Street, N C 793, Chicago, IL 60612, USA
    Clin J Am Soc Nephrol 5:821-7. 2010
    ..Normalizing Kt/V to body surface area (S) has been proposed, but the implications of doing this in children have not been examined.
  82. doi Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study
    Line Cleemann
    Department of Paediatrics, Hillerød Hospital, 3400 Hillerød, Denmark
    Pediatr Cardiol 31:497-504. 2010
    ..The thoracic aortic diameters of the patients were measured at nine positions. Adjustment for body surface area (BSA) was performed...
  83. ncbi [An index internal diameter ductus arteriosus/body surface area as a need for closure of duct in the preterm newborn]
    Carlos Antonio Tapia-Rombo
    Servicio de Neonatologia, Unidad Medica de Alta Especialidad, Hospital General Dr Gaudencio Gonzalez Garza, Centro Medico Nacional La Raza, IMSS
    Rev Invest Clin 65:12-23. 2013
    To determine a rate of internal diameter (ID), the narrowest of ductus arteriosus (DA)/body surface area (BSA) in preterm newborns (PTNB) for need for closure of DA either medically or surgically.
  84. ncbi Body surface area and body weight predict total liver volume in Western adults
    Jean Nicolas Vauthey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Liver Transpl 8:233-40. 2002
    ..This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measured in 292 patients from four Western centers...
  85. ncbi A trial of the effectiveness of artificial dermis in the treatment of patients with burns greater than 45% total body surface area
    Michael D Peck
    North Carolina Jaycee Burn Center and the Department of Surgery, University of North Carolina Health Care, Chapel Hill, North Carolina 27514, USA
    J Trauma 52:971-8. 2002
  86. doi A simple procedure for estimation of total body surface area and determination of a new value of Meeh's constant in rats
    E Gouma
    Laboratory of Physiology, University of Ioannina, 45110 Ioannina, Greece
    Lab Anim 46:40-5. 2012
    Precise calculation of total body surface area (TBSA) or premarked surface areas (P-MSAs) is of great importance in many biomedical applications...
  87. ncbi Echocardiographic characteristics of professional football players
    William B Abernethy
    Cardiac Unit, Massachusetts General Hospital, Boston, USA
    J Am Coll Cardiol 41:280-4. 2003
    ..We examined the echocardiographic characteristics of highly trained American football players...
  88. doi Aortic valve disease in Turner syndrome
    Vandana Sachdev
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Am Coll Cardiol 51:1904-9. 2008
    ..Our goal was to determine the prevalence and characteristics of aortic valve disease in girls and women with monosomy for the X chromosome, or Turner syndrome (TS)...
  89. ncbi Use of body surface area (BSA)-based dosages to calculate chemotherapeutic drug dose in dogs: I. Potential problems with current BSA formulae
    G S Price
    Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Vet Intern Med 12:267-71. 1998
    The dose of most cancer chemotherapeutic drugs administered to dogs is calculated on the basis of estimated body surface area (BSA); however results of some chemotherapy trials have revealed that this dosing method increases toxicosis in ..
  90. doi Magnetic-resonance-imaging-derived indices for the normalization of left ventricular morphology by body size
    Keith P George
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, L3 2ET Liverpool, UK
    Magn Reson Imaging 27:207-13. 2009
    ..The traditional method of simple ratio scaling using, for example, body surface area (BSA) assumes a linear and proportional relationship and accurate measurement of both LV mass and BSA...
  91. ncbi Impact of body-size measures on irinotecan clearance: alternative dosing recommendations
    Ron H J Mathijssen
    Department of Medical Oncology, Rotterdam Cancer Institute Daniel den Hoed Kliniek, 3008 AE Rotterdam, The Netherlands
    J Clin Oncol 20:81-7. 2002
    ..To evaluate relationships between various body-size measures and irinotecan (CPT-11) clearance and metabolism in cancer patients, and to provide future dosing recommendations for this agent...
  92. ncbi Relationship of body surface area with bone density and its risk of osteoporosis at various skeletal regions in women of mainland China
    Xian Ping Wu
    Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, 86 Renmin Zhong Road, 410011, Changsha, Hunan, People s Republic of China
    Osteoporos Int 15:751-9. 2004
    The aim of this study was to investigate the relationship between body surface area (BS) and bone mineral density (BMD) and the associated osteoporosis risk at various skeletal regions in women from mainland China...
  93. ncbi Hot beverage burns: an 11-year experience of the Yorkshire Regional Burns Centre
    Christopher L Hankins
    Department of Plastic Surgery, Pinderfields General Hospital, Aberford Road, Wakefield WF1 4DG, UK
    Burns 32:87-91. 2006
    ..Changes in referral patterns over this period resulted in a decrease in the mean total body surface area of injury, an increase in the number of admissions and an increase in the time interval from injury to ..
  94. ncbi Burn patterns of Asian ethnic minorities living in West Yorkshire, UK
    J M Rawlins
    Plastic Surgery and Burns Research Unit, University of Bradford, Richmond Road, Bradford BD7 1 DP, UK
    Burns 32:97-103. 2006
    ..Much of this is behaviour related, and it is hoped that through preventative measures a marked reduction in the number of Asian ethnic minority burns can be achieved...
  95. ncbi Hot oil burns--a study of predisposing factors, clinical course and prevention strategies
    Christopher L Hankins
    Department of Plastic Surgery, Pinderfields General Hospital, Aberford Road, Wakefield, WA6, UK
    Burns 32:92-6. 2006
    ..The total body surface area of adults and children were similar, i.e. 7.15 +/- 5.49% versus 7.23 +/- 6.87%...
  96. ncbi A simplified weight-based method for pediatric drug dosing for zidovudine and didanosine in resource-limited settings
    Paul J Weidle
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:59-64. 2006
    ..drugs used for human immunodeficiency virus (HIV)-infected children with dose recommendations based on body surface area calculations...
  97. ncbi Etiology and outcome of pediatric burns in Tabriz, Iran
    Hemmat Maghsoudi
    Department of Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    Burns 31:721-5. 2005
    ..There were 39 deaths related to scalds. Large burn size was the strongest predictor of mortality followed by the presence of inhalation injury and the length of time to intravenous access...
  98. ncbi Analysis of pediatric burns in Nagasaki University from 1983 to 2002
    Sadanori Akita
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine Nagasaki University, Graduate School of Biomedical and Sciences, 1 7 1 Sakamoto, Nagasaki 852, Japan
    Burns 31:1041-4. 2005
    ..4+/-14.6% versus 6.6+/-13.26%, TBSA). Pediatric burns in younger children should be studied closely as to their causes and with further follow-up...
  99. ncbi Sonographic assessment of the normal limits and percentile curves of liver, spleen, and kidney dimensions in healthy school-aged children
    Alp Alper Safak
    Department of Radiology, Duzce School of Medicine, Abant Izzet Baysal University, Konuralp 81620, Duzce, Turkey
    J Ultrasound Med 24:1359-64. 2005
    ..purpose of this study was to determine the normal standards of liver, spleen, and kidney dimensions and the relationship of each with sex, age, body weight, height, body mass index, and body surface area in healthy school-aged children.
  100. ncbi Indexation criteria of ventricular mass and predictive role of blood pressure and body composition
    Liberato Aldo Ferrara
    Department of Clinical and Experimental Medicine, Federico 2nd University of Naples, Naples, Italy
    Am J Hypertens 18:1282-7. 2005
    ..Left ventricular mass has been adjusted to height, to height2.7(h2.7) and to body surface area (BSA)...
  101. ncbi Paediatric burns in Kuwait: incidence, causes and mortality
    Prem N Sharma
    Health Sciences Center, Kuwait University, Kuwait
    Burns 32:104-11. 2006
    ..Gender and nationality had no influence on incidence or mortality. These findings will hopefully stimulate development of targeted and sustainable interventions for reducing burns occurrence among identified paediatric high-risk groups...

Research Grants79

  1. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..Individuals with severe generalied RDEB develop blisters and erosions involving large portions of the body surface area, mutilating scarring, joint contractures, and strictures of the esophagus, with opportunistic infections and ..
  2. Preventing Burn Wound Infection Using a Novel Free Radical Sterilization System
    BENJAMIN DAVID SADOWITZ; Fiscal Year: 2011
    ..Indeed, for those patients with burn size greater than 40% of total body surface area, 75% of all deaths are due to infection...
  3. Comparative Effectiveness of Biologics for Psoriasis
    Joel M Gelfand; Fiscal Year: 2010
    ..quality of life, economic impact, and treatment satisfaction) and physician reported outcomes (such as body surface area affected by psoriasis) in various subgroups of patients treated in routine clinical practice at a given ..
  4. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..In patients with >30% of total body surface area burned, protein breakdown persists for approximately one year after the burn wound is 95% healed...
  5. MYOCARDIAL PROTECTION: REPERFUSION INJURY AMELIORATION
    James D McCully; Fiscal Year: 2010
    ..However;after adjusting for all co-morbidities including body surface area, female gender is an independent predictor of increased mortality following CABG, with a risk adjusted ..
  6. Pharmacogenetics of Cyclophosphamide ADRs in
    Jeannine S McCune; Fiscal Year: 2012
    ..The current method of dosing CY by body surface area or weight leads to considerable interpatient variability in the systemic exposure, expressed as area under ..
  7. Psoriasis and the risk of diabetes
    Joel M Gelfand; Fiscal Year: 2013
    ..However, it is not known how clinical aspects of psoriasis (such as body surface area of involvement, anatomic sites of involvement, etc) impact diabetes risk nor is it known if successful ..
  8. Control of skin blood flow and sweating in grafted skin
    Craig G Crandall; Fiscal Year: 2012
    ..of this number between 6,400 and 11,200 have severe burns covering at least 20% of the person's total body surface area (BSA). Twenty years ago burns covering half of a person's BSA were fatal...
  9. Pharmacogenetics in children with high-risk neuroblastoma
    Jeannine S McCune; Fiscal Year: 2013
    ..The current method of dosing CY by body surface area or weight leads to considerable interpatient variability in the systemic exposure, expressed as area under ..
  10. Regulation of Human Muscle Protein Metabolism Following Burn Injury
    EDWARD KELLY MERRITT; Fiscal Year: 2012
    ..answer these questions, serum and muscle samples will be obtained from subjects burned over 20-60% of total body surface area and compared to those from matched controls...
  11. CALERIE Competitive Renewal
    William E Kraus; Fiscal Year: 2013
    ..There was a decrease in basic metabolic rate when adjusted for body surface area, body weight, and cell mass...
  12. PINEAL FUNCTION IN CHILDHOOD AND ADOLESCENCE
    Anita Cavallo; Fiscal Year: 1990
    ..Finally, plasma and urinal melatonin concentrations will be correlated with body weight and body surface area. Information gained from these studies may clarify the role of the pineal gland in puberty and the data will ..
  13. PHYSIOLOGIC RESPONSE TO THERMAL INJURY
    EDWARD PAVLIN; Fiscal Year: 1990
    ..Preliminary work has established that rats with a 30% total body surface area thermal injury show a similar time course of resistance to atracurium as that observed with patients...
  14. UV, Neuropeptides, Histamine and Buruli Ulcer Disease
    RHIAN COPE; Fiscal Year: 2005
    ..This emergent, high-morbidity disease causes destructive skin ulcers that may cover up to 15% of the body surface area. Secondary infection of the ulcers is extremely rare...
  15. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    James Brindle; Fiscal Year: 2005
    ..of scaling methods to include anthropometric parameters (total body mass, body height, lean body mass, body surface area, and body mass index), tissue volumes (active marrow and spongiosa), and tissue masses (active marrow and ..
  16. MENTORED MEDICAL STUDENT CLINICAL RESEARCH PROGRAM
    David Herndon; Fiscal Year: 2000
    ..However, the long term sequelae of children suffering a greater than 40 percent total body surface area burn include a reduction in growth velocity up to 3 years post-burn with permanent stunting...
  17. Modeling Genotype and other Factors to Enhance the Safety of Warfarin Prescribing
    Michael Caldwell; Fiscal Year: 2007
    ..projects stable dose as a function of variability contributed by clinical factors including gender, age, body surface area, diabetes status, heart valves, concomitant use of CYP2C9 inducers, and genetic factors including CYP2C9 and ..
  18. NEUTROPHIL SIGNALING & EFFECTOR RESPONSES IN BURN INJURY
    Masakatsu Goto; Fiscal Year: 2005
    ..of PM"s inappropriate portentiated responses will be carried out in a rat model of 30 percent total body surface area burn plus an intraabdominal inoculation of Enterococcus faecalis using two strains of the organism, one ..
  19. OPTIMIZED CANCER CHEMOTHERAPY VIA PHARMACODYNAMIC MODELS
    James Gallo; Fiscal Year: 2000
    ..used in Phase II and Phase III trials, all patients receive the same dose, normalized to body weight or body surface area, dictated by the MTD, thus, preventing the use of a dosing regimen tailored to an individual...
  20. TREATMENT OF BODY IMAGE IN A DISFIGURED POPULATION
    Leslie Heinberg; Fiscal Year: 1999
    ..This population was selected because burns are discrete events and measures of severity (e.g., total body surface area) are readily available...
  21. Cytokine networks in psoriasis
    Edmund Lee; Fiscal Year: 2004
    ..be variable with some patients having only elbows and knees involved while others have 50% or more of their body surface area involved. Therapy depends on the severity of the disease...
  22. THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTION
    Martin Schwacha; Fiscal Year: 2003
    ..We have utilized a murine scald burn model (3rd degree, 25 percent total body surface area) and our preliminary results indicated that at 4-7 days post-burn Mphi were "hyperactive" as increased ..
  23. BIAS IN COMPARING OUTCOMES OF BURN UNITS
    Charles Berry; Fiscal Year: 1980
    ..Estimated percentages of body surface area burned, which are used to adjust the outcomes of different burn units, have substantial measurement error...
  24. THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTION
    Martin Schwacha; Fiscal Year: 2006
    ..We have utilized a murine scald burn model (3rd degree, 25% total body surface area) and our preliminary results indicated that at 4-7 days post-burn Mphi were "hyperactive" (increased ..
  25. Acetylator-based Individualized Dosing of Amonadife
    John Lister James; Fiscal Year: 2005
    ..dosing has traditionally been empiric, with all patients receiving the same dose adjusted for body surface area (BSA)...
  26. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  27. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
  28. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  29. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  30. Pharmacogenetics and Antithrombotic Therapy
    Brian Gage; Fiscal Year: 2003
    ..Using high performance liquid chromatography, we will measure the levels of the 2 enantiomers of warfarin and test Hypothesis 4: Clearance of S-warfarin will be significantly decreased in the presence of 2C9 SNPs. ..
  31. Physiological Adaptations to Exercise in Burned Children
    Oscar Suman; Fiscal Year: 2006
    ..We expect these Specific Aims to serve as a springboard for future studies in the treatment and long-term rehabilitation of burned children. ..
  32. Interleukin-18 and Intestinal Barrier Function Following Alcohol and Burn Injury
    Mashkoor Choudhry; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Feasibility of Rehabilitation Robots and fMRI in Stroke
    A Tzika; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  34. Oxidative Stress and Vitamin E Requirements
    Maret Traber; Fiscal Year: 2005
    ..These proposed studies will further our goal of understanding the role of vitamin E in the amelioration of oxidative damage in aging and in chronic diseases, such as heart disease, diabetes and cancer. ..
  35. Bone Health in Pediatric Crohn Disease: A Low Magnitude Mechanical Stimulus Trial
    MARY BETH LEONARD; Fiscal Year: 2010
    ..The NIH Osteoporosis Consensus Statement called for studies to identify interventions that promote bone health in children at risk. LMMS may provide a safe and effective treatment for myriad chronic pediatric diseases. ..
  36. Low Magnitude Mechanical Stimuli Effects on Bone Structu
    Mary Leonard; Fiscal Year: 2006
    ..Consistent with the Program Announcement, it is anticipated that this innovative study will lead to a full-scale clinical trial of LMMS as an anabolic bone therapy for ROD in dialysis patients. ..
  37. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2007
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  38. Racial Differences--Stress Induced Homeostatic Response
    Gregory Harshfield; Fiscal Year: 2005
    ..abstract_text> ..
  39. Vitamin D Deficiency, Physical Performance and Cardiovascular Outcomes in CRIC
    Mary Leonard; Fiscal Year: 2009
    ..Delineation of the relations between 25(OH)D and 1,25(OH)2D and clinical outcomes is necessary in order to develop anticipated randomized trials of vitamin D supplementation in CRI. ..
  40. "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"
    Allon Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  41. COCAINE EXPOSED INFANTS--CARDIAC PROBLEMS AND OUTCOME
    Sudhir Mehta; Fiscal Year: 2001
    ..Therefore, it is crucial to understand the natural history of the cardiovascular abnormalities before measures can be directed toward their treatment and prevention. ..
  42. NUTRITIONAL INTERVENTION FOR CANCER CACHEXIA
    John Fuller; Fiscal Year: 2002
    ..It is envisioned that these products will be highly effective over-the-counter and/or prescription nutritional supplements for cancer patients with cachexia to improve quality of life of cancer patients. ..
  43. INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TEST
    Edward Acosta; Fiscal Year: 2006
    ..abstract_text> ..
  44. Cadmium Exposure and Breast Cancer Risk
    Jane McElroy; Fiscal Year: 2005
    ..The study team brings together expertise in breast cancer and environmental epidemiology, laboratory science, and biostatistics to efficiently address the role of cadmium in the etiology of breast cancer. ..
  45. Ethnic differences in peripheral arterial disease
    Michael Criqui; Fiscal Year: 2004
    ..This is the first attempt to see if these newer risk markers can explain ethnic differences in PAD. Thus, this application is highly innovative and addresses original hypotheses. ..
  46. ECHOCARDIOGRAPHIC STROKE PREDICTORS IN A TRI-ETHNIC COMM
    Marco Di Tullio; Fiscal Year: 2003
    ..This study will be the first prospective cohort study to evaluate the role of multiple echocardiographic risk factors for ischemic stroke in a community of whites, blacks and Hispanics living in the same area. ..
  47. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  48. Aortic, Cardiovascular Disease and Silent Brain Infarcts
    Marco Di Tullio; Fiscal Year: 2009
    ..The present application will help fill gaps in knowledge on silent brain infarcts and their risk factors in the elderly, and identify subjects at higher risk before a symptomatic stroke or other vascular event occurs. ..
  49. Antioxidant Supplementation,Oxidative Stress & Enduranc*
    Maret Traber; Fiscal Year: 2002
    ..Finally, the investigators plan to measure markers of inflammatory response, such as C-oxidants increase and vitamin E decreases these markers. ..
  50. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  51. Neural and non-neural modulators of skin blood flow and sweating in humans
    CRAIG CRANDALL; Fiscal Year: 2009
    ..e. diabetes, heart failure, etc) and non-disease (i.e. aging) conditions. ..
  52. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  53. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..the molecular targets altered by - tocopherol-deficiency in the zebrafish will provide a solid basis for understanding why humans require -tocopherol for reproduction as well as to maintain a healthy nervous system ..
  54. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  55. CRIC-Plus: Study of Advanced Chronic Renal Insufficiency
    Chi yuan Hsu; Fiscal Year: 2010
    ..Aim #4: To study the effect of chronic renal insufficiency management, including the timing of dialysis initiation, on clinical outcomes after onset of end-stage renal disease. ..
  56. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2009
    ..We believe that our findings may well have a significant impact on current self-medication practices of the millions of Americans currently taking prescription drugs and vitamin E supplements. ..
  57. Concept: Stress, Cytokines and Heart Disease in Police
    WARREN FRANKE; Fiscal Year: 2007
    ..The proposed work is significant because it is expected to increase our understanding of the mechanisms underlying the pathogenesis of cardiovascular disease in this high stress occupation. [unreadable] [unreadable] [unreadable]..
  58. MECHANISMS OF WOUND HEALING WITH CULTURED HUMAN SKIN
    Steven Boyce; Fiscal Year: 2005
    ..Accomplishment of these objectives will contribute to reduced mortality and morbidity from burns, improved materials for plastic and reconstructive surgery, and development of other tissue and organ substitutes. ..
  59. Cytokine induced abnormal wound healing
    Warren Garner; Fiscal Year: 2005
    ..The long-term goal of this project is to uncover key mechanisms underlying hypertrophic scarring that may lead to improved therapeutic and, perhaps, preventive strategies. ..
  60. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  61. Skin Cooling to Improve Orthostatic Tolerance
    CRAIG CRANDALL; Fiscal Year: 2005
    ....
  62. Mentored Patient-Oriented Research Career Development Aw
    ASHER SCHACHTER; Fiscal Year: 2004
    ..These studies may provide insight and guidance for the development of markers of steroid resistance as well as novel therapies for SRNS. ..
  63. CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGY
    Sewon Kang; Fiscal Year: 2004
    ..abstract_text> ..
  64. VIRAL HEPATITIS IN CHILDREN OF INJECTION DRUG USERS
    Kathleen Schwarz; Fiscal Year: 2003
    ....
  65. TOMOGRAPHIC DOSIMETRY PHANTOMS FOR PEDIATRIC RADIOLOGY
    Wesley Bolch; Fiscal Year: 2002
    ....
  66. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  67. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ....
  68. STRUCTURAL EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
    Mary Leonard; Fiscal Year: 2006
    ....
  69. 4th International Conference on Children's Bone Health
    Mary Leonard; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  70. Linking acute, chronic and end-stage renal disease
    Chi yuan Hsu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  71. HENRY FORD HOSPITAL CPCRA UNIT
    Norman Markowitz; Fiscal Year: 2006
    ..The HFH CPCRA unit expects to enroll a minimum of 250 HIV-infected patients on study at any given time throughout the course of this grant. ..
  72. Advances in Skeletal Dosimetry Through Microimaging
    Wesley Bolch; Fiscal Year: 2006
    ..abstract_text> ..
  73. Safer Antithrombotic Therapy for Elderly ACS Patients
    Eric Peterson; Fiscal Year: 2006
    ..Finally, we will use established relations with professional societies and the VHA to widely disseminate our study's major findings. ..
  74. Impaired Sodium Regulation and BP in Obese Youth
    Gregory Harshfield; Fiscal Year: 2006
    ..Finally, measures of target organ change will include left ventricular mass, diastolic function, and glomerular hyperfiltration as estimated from creatinine clearance. ..
  75. Consequences of Chronic Renal Insufficiency
    Chi yuan Hsu; Fiscal Year: 2006
    ..These will contribute greatly to my development into an independent investigator. ..
  76. GLUCOCORTICOID-INDUCED OSTEOPENIA IN CHILDREN
    Mary Leonard; Fiscal Year: 2005
    ..The accurate characterization of GC and disease effects on skeletal development is necessary to identify and evaluate targeted therapies to optimize skeletal architecture and peak bone mass in childhood. ..
  77. IRAK Family Function in Bacterial Infection
    James Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  78. TOMOGRAPHIC DOSIMETRY PHANTOMS FOR PEDIATRIC RADIOLOGY
    Wesley Bolch; Fiscal Year: 2001
    ....