autopsy

Summary

Summary: Postmortem examination of the body.

Top Publications

  1. pmc TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
    Michael A Gitcho
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Acta Neuropathol 118:633-45. 2009
  2. pmc Verbal autopsy: current practices and challenges
    Nadia Soleman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 84:239-45. 2006
  3. doi Verbal autopsy: methods in transition
    Edward Fottrell
    Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Epidemiol Rev 32:38-55. 2010
  4. ncbi Validity of verbal autopsy procedures for determining cause of death in Tanzania
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Trop Med Int Health 11:681-96. 2006
  5. pmc Refining a probabilistic model for interpreting verbal autopsy data
    Peter Byass
    Umeå International School of Public Health, Umea University, Umea, Sweden
    Scand J Public Health 34:26-31. 2006
  6. pmc The worldwide epidemiology of prostate cancer: perspectives from autopsy studies
    Gabriel P Haas
    Department of Urology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Can J Urol 15:3866-71. 2008
  7. doi Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 18:4808-17. 2009
  8. ncbi Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses
    Janneke A Cox
    Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Rev 12:183-94. 2010
  9. pmc Verbal autopsy coding: are multiple coders better than one?
    Rohina Joshi
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Bull World Health Organ 87:51-7. 2009
  10. pmc Verbal autopsy: reliability and validity estimates for causes of death in the Golestan Cohort Study in Iran
    Hooman Khademi
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences Tehran, Iran
    PLoS ONE 5:e11183. 2010

Detail Information

Publications346 found, 100 shown here

  1. pmc TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
    Michael A Gitcho
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Acta Neuropathol 118:633-45. 2009
    ..Since that study, brain tissue has become available and provides autopsy confirmation of FTLD-TDP in the proband and ALS in the brother of the bvFTD-ALS family and the neuropathology of ..
  2. pmc Verbal autopsy: current practices and challenges
    Nadia Soleman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 84:239-45. 2006
    Cause-of-death data derived from verbal autopsy (VA) are increasingly used for health planning, priority setting, monitoring and evaluation in countries with incomplete or no vital registration systems...
  3. doi Verbal autopsy: methods in transition
    Edward Fottrell
    Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Epidemiol Rev 32:38-55. 2010
    ..In the absence of routine death registration, verbal autopsy (VA) methods are used to derive probable causes of death...
  4. ncbi Validity of verbal autopsy procedures for determining cause of death in Tanzania
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Trop Med Int Health 11:681-96. 2006
    To validate verbal autopsy (VA) procedures for use in sample vital registration...
  5. pmc Refining a probabilistic model for interpreting verbal autopsy data
    Peter Byass
    Umeå International School of Public Health, Umea University, Umea, Sweden
    Scand J Public Health 34:26-31. 2006
    To build on the previously reported development of a Bayesian probabilistic model for interpreting verbal autopsy (VA) data, attempting to improve the model's performance in determining cause of death and to reassess it.
  6. pmc The worldwide epidemiology of prostate cancer: perspectives from autopsy studies
    Gabriel P Haas
    Department of Urology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Can J Urol 15:3866-71. 2008
    ..Prostate cancer is the most frequently diagnosed non-skin cancer in the United States and the third leading cause of cancer deaths. International trends in the incidence, mortality and prevalence of prostate cancer are assessed...
  7. doi Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 18:4808-17. 2009
    ..05). Finally, we found that the Illumina GoldenGate assay features a large number of probes (265/1505 probes, 17.6%) that contain single-nucleotide polymorphisms, which may interfere with DNA methylation analyses in genome-wide studies...
  8. ncbi Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses
    Janneke A Cox
    Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Rev 12:183-94. 2010
    ..Pathological autopsies are the gold standard to establish causes of death. In this review we describe the autopsy series performed among HIV-infected individuals in sub-Saharan Africa over the last two decades...
  9. pmc Verbal autopsy coding: are multiple coders better than one?
    Rohina Joshi
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Bull World Health Organ 87:51-7. 2009
    To assess the impact on the reported cause-of-death patterns of a verbal autopsy coding strategy based on a review of every death by multiple coders versus a single coder.
  10. pmc Verbal autopsy: reliability and validity estimates for causes of death in the Golestan Cohort Study in Iran
    Hooman Khademi
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences Tehran, Iran
    PLoS ONE 5:e11183. 2010
    Verbal autopsy (VA) is one method to obtain valid estimates of causes of death in the absence of valid medical records...
  11. pmc Moving from data on deaths to public health policy in Agincourt, South Africa: approaches to analysing and understanding verbal autopsy findings
    Peter Byass
    Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umea University, Sweden
    PLoS Med 7:e1000325. 2010
    ..Interviewing family and friends after a death has occurred (a procedure known as verbal autopsy) provides a source of data where deaths otherwise go unregistered; but sound methods for interpreting and ..
  12. pmc Factors associated with physician agreement on verbal autopsy of over 27000 childhood deaths in India
    Shaun K Morris
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    PLoS ONE 5:e9583. 2010
    ..The large majority of these deaths occur in the developing world. The verbal autopsy (VA) is a tool designed to ascertain cause of death in such settings...
  13. pmc Assessing a new approach to verbal autopsy interpretation in a rural Ethiopian community: the InterVA model
    Mesganaw Fantahun
    Department of Community Health, Addis Ababa University, Ethiopia
    Bull World Health Organ 84:204-10. 2006
    Verbal autopsy (VA) -- the interviewing of family members or caregivers about the circumstances of a death after the event -- is an established tool in areas where routine death registration is non-existent or inadequate...
  14. ncbi Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study
    Neil A Martinson
    Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA
    AIDS 21:2043-50. 2007
    ..To ascertain the immediate and underlying causes of death in adults who died in hospital with a premortem diagnosis of tuberculosis...
  15. pmc Setting international standards for verbal autopsy
    Frank Baiden
    Bull World Health Organ 85:570-1. 2007
  16. ncbi Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998
    N A Ansari
    The BOTUSA Project, Gaborone, Botswana
    Int J Tuberc Lung Dis 6:55-63. 2002
    ..Little is known about causes of death in countries of southern Africa seriously affected by the HIV/AIDS epidemic...
  17. ncbi Validation of verbal autopsy procedures for adult deaths in China
    Gonghuan Yang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 5, Dong Dan San Tiao, 100005 Beijing, China
    Int J Epidemiol 35:741-8. 2006
    ..Information on the leading causes of mortality will continue to rely on verbal autopsy (VA) methods...
  18. ncbi Post-mortem findings in harbour porpoises (Phocoena phocoena) from the German North and Baltic Seas
    U Siebert
    , , Frankfurter Strasse 96, 35392 Giessen, Germany
    J Comp Pathol 124:102-14. 2001
    ..Beta-haemolytic streptococci were considered to be the main infectious agents. Morbillivirus antigen was not detected immunohistochemically...
  19. doi Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa
    Biruk Tensou
    Addis Ababa Mortality Surveillance Project, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 15:547-53. 2010
    To evaluate the performance of a verbal autopsy (VA) expert algorithm (the InterVA model) for diagnosing AIDS mortality against a reference standard from hospital records that include HIV serostatus information in Addis Ababa, Ethiopia.
  20. ncbi Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p)reactive lesions
    C J De Groot
    Department of Pathology, MS Centre for Research and Care MSCRC, Vrije Universiteit Medical Centre and Netherlands Brain Bank, Amsterdam, The Netherlands
    Brain 124:1635-45. 2001
    ..The Netherlands Brain Bank organized the rapid autopsy of 29 multiple sclerosis patients. The brain was cut in 1 cm coronal slices...
  21. ncbi Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003)
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, Laboratory Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Haematologica 91:986-9. 2006
    We evaluated autopsy-proven invasive fungal infections (IFI) in patients with hematologic malignancies over three periods (1989-1993, 1994-1998, and 1999-2003). The autopsy rate declined significantly (67%-34%-26%, respectively p<0...
  22. ncbi Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases
    H Kondo
    Dept of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Endoscopy 33:507-10. 2001
    ..Of these, 347 were identified from a series of 6380 autopsy cases; 54 patients were diagnosed endoscopically while alive, 12 of whom had confirmation of the condition at ..
  23. ncbi Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan.
  24. ncbi Changes in rates of autopsy-detected diagnostic errors over time: a systematic review
    Kaveh G Shojania
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    JAMA 289:2849-56. 2003
    Substantial discrepanies exist between clinical diagnoses and findings at autopsy. Autopsy may be used as a tool for quality management to analyze diagnostic discrepanies.
  25. pmc Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India
    Vendhan Gajalakshmi
    Epidemiological Research Center, Chennai, India
    BMC Public Health 4:47. 2004
    ..A special verbal autopsy (VA) study of 48,000 adult (aged >or= 25 yrs) deaths in the city of Chennai (urban) during 1995-97 and 32,000 ..
  26. pmc Ostial plication: a rarely reported cause of sudden death
    Fabio De-Giorgio
    Institute of Legal Medicine, Catholic University, School of Medicine, Rome, Italy
    Diagn Pathol 5:15. 2010
    ..Ostial plication may be a source of sudden death or cause of death when no other significant autopsy findings are present.Ostial plication is a congenital severe obstruction/occlusion of the right or left ostium...
  27. pmc Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests
    Valeria Iodice
    Neurovascular and Autonomic Medicine Unit, Imperial College London, UK
    J Neurol Neurosurg Psychiatry 83:453-9. 2012
    ..Published autopsy confirmed cases have provided reasonable neurological characterisation but have lacked adequate autonomic ..
  28. pmc Strengthening standardised interpretation of verbal autopsy data: the new InterVA-4 tool
    Peter Byass
    Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Glob Health Action 5:1-8. 2012
    Verbal autopsy (VA) is the only available approach for determining the cause of many deaths, where routine certification is not in place...
  29. pmc Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak
    Zong Mei Sheng
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:16416-21. 2011
    ..These findings have important implications for understanding the origins and evolution of pandemic influenza viruses...
  30. pmc Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death
    John R Giudicessi
    Division of Cardiovascular Diseases, Department of Medicine, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Mutat 33:989-97. 2012
    ..Brugada syndrome (BrS) and idiopathic ventricular fibrillation (IVF), may serve as the pathogenic basis for autopsy-negative sudden unexplained death (SUD) and sudden infant death syndrome (SIDS)...
  31. doi Pathology and virology findings in cases of fatal influenza A H1N1 virus infection in 2009-2010
    Amanjit Bal
    Department of Histopathology, Post Graduate Institute of Medical Sciences and Research, Sector 12, Chandigarh, India
    Histopathology 60:326-35. 2012
    ....
  32. ncbi Understanding the unique characteristics of suicide in China: national psychological autopsy study
    Gong Huan Yang
    Chinese Academy of Preventive Medicine, Beijing, China
    Biomed Environ Sci 18:379-89. 2005
    ..To compare the characteristics of suicides in the four main demographic groups: urban males, urban females, rural males and rural females in order to help clarify the demographic pattern of suicides in China...
  33. doi Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 118:1138-45. 2008
    The long-term safety of drug-eluting stents (DES) for acute myocardial infarction (AMI) remains uncertain. Using autopsy data, we evaluated the pathological responses of the stented segment in patients treated with DES for AMI and ..
  34. ncbi Applying verbal autopsy to determine cause of death in rural Vietnam
    Dao Lan Huong
    Health Strategy and Policy Institute, Ministry of Health, Hanoi, Vietnam
    Scand J Public Health Suppl 62:19-25. 2003
    Verbal autopsy (VA) is an attractive method for ascertaining causes of death in settings where the proportion of people who die under medical care is low...
  35. doi Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: an autopsy study
    Søren Dalager
    Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Skejby, Arhus, Denmark
    J Vasc Surg 47:296-302. 2008
    ..Assessment of subclinical atherosclerosis in peripheral arteries might improve this limitation. We studied the relationship between atherosclerotic plaques in peripheral arteries, coronary plaques, and coronary death...
  36. ncbi Childhood mortality and probable causes of death using verbal autopsy in Niakhar, Senegal, 1989-2000
    Jean Francois Etard
    Institut de Recherche pour le Développement IRD BP 1386 Dakar, Senegal
    Int J Epidemiol 33:1286-92. 2004
    ..The authors applied the verbal autopsy to identify causes of death before 15 years old in a rural area of Senegal where a demographic surveillance ..
  37. pmc Verbal autopsy can consistently measure AIDS mortality: a validation study in Tanzania and Zimbabwe
    B Lopman
    Imperial College, London, UK
    J Epidemiol Community Health 64:330-4. 2010
    Verbal autopsy is currently the only option for obtaining cause of death information in most populations with a widespread HIV/AIDS epidemic.
  38. pmc Methodological trends in studies based on verbal autopsies before and after published guidelines
    Rohina Joshi
    George Institute for International Health, University of Sydney, Sydney NSW, Australia
    Bull World Health Organ 87:678-82. 2009
    To report on the uptake of guidelines published in the early 1990s with specific recommendations about the design of future studies based on verbal autopsy conducted for mortality surveillance.
  39. doi Prevalence of dementia disorders in the oldest-old: an autopsy study
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria
    Acta Neuropathol 119:421-33. 2010
    ..hospital-based study of the relative prevalence of different disorders was performed in 1,110 consecutive autopsy cases of demented elderly in Vienna, Austria (66% females, MMSE <20; mean age 83.3 +/- 5.4 SD years)...
  40. doi Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia
    Paul C Guest
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Psychoneuroendocrinology 36:1092-6. 2011
    ..This could have important implications for future biomarker discovery efforts and personalized medicine strategies based on patient stratification for the treatment of this debilitating disorder...
  41. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
    ..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior...
  42. ncbi Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings
    Andres Esteban
    Hospital Universitario de Getafe, Madrid, Spain
    Ann Intern Med 141:440-5. 2004
    ..The American-European Consensus Conference definition for the acute respiratory distress syndrome (ARDS) has never been validated...
  43. pmc Voxel-based morphometry in autopsy proven PSP and CBD
    Keith A Josephs
    Department of Neurology Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 29:280-9. 2008
    The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending ..
  44. doi Metastatic patterns of cancers: results from a large autopsy study
    Guy DiSibio
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Arch Pathol Lab Med 132:931-9. 2008
    ..Many studies have addressed metastatic patterns seen among various cancers. No recent studies, however, provide quantitative analyses of such patterns arising from a broad range of cancers based primarily on postmortem tissue analyses...
  45. ncbi Validation and application of verbal autopsies in a rural area of South Africa
    K Kahn
    Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 5:824-31. 2000
    To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in the Agincourt subdistrict of rural South Africa.
  46. ncbi Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death
    D H Chace
    Neo Gen Screening, PO Box 219, Bridgeville, PA 15017, USA
    Clin Chem 47:1166-82. 2001
    ..Tandem mass spectrometry (MS/MS) may reveal disorders of fatty acid oxidation in deaths of previously unknown cause...
  47. ncbi Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital ZNA, Lindendreef 1, 2020 Antwerp, Belgium
    Neurobiol Aging 29:1143-59. 2008
    ..181 (P-tau(181P)) compared to clinical diagnosis, biomarker levels were determined in CSF samples from 100 autopsy-confirmed dementia and 100 control subjects...
  48. ncbi Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants
    Lon White
    Kuakini Medical Center, 846 S Hotel Street, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 977:9-23. 2002
    ..The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction...
  49. ncbi Validation of verbal autopsy to determine the cause of 137 neonatal deaths in Karachi, Pakistan
    David R Marsh
    Office of Health, Save the Children Federation US, Westport, CT, USA
    Paediatr Perinat Epidemiol 17:132-42. 2003
    Verbal autopsy (VA) aims to estimate a community's mortality experience in the absence of contact with formal registration or health care systems...
  50. pmc Validation of the symptom pattern method for analyzing verbal autopsy data
    Christopher J L Murray
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America
    PLoS Med 4:e327. 2007
    ..of reliable vital registration data, information collected after death from household members, called verbal autopsy (VA), is commonly used to study causes of death...
  51. pmc Culture, risk factors and suicide in rural China: a psychological autopsy case control study
    J Zhang
    Department of Sociology, State University of New York College at Buffalo, NY 14222, USA
    Acta Psychiatr Scand 110:430-7. 2004
    ..The current study examines the major risk factors and some cultural uniqueness related to Chinese rural suicide using a quantitative design...
  52. ncbi Is there progress in the autopsy diagnosis of sudden unexpected death in adults?
    Geoffroy Lorin de la Grandmaison
    Department of Forensic Medicine and Pathology, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, 104 boulevard Raymond Poincaré, F 92380 Garches, France
    Forensic Sci Int 156:138-44. 2006
    ..Sudden death in the young always requires systematic forensic autopsy performed by at least one forensic pathologist...
  53. pmc Clinico-pathological discrepancies in the diagnosis of causes of maternal death in sub-Saharan Africa: retrospective analysis
    Jaume Ordi
    Department of Pathology Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    PLoS Med 6:e1000036. 2009
    ..Clinical diagnostic errors may play a significant role in this problem and might also have major implications for the evaluation of current estimations of causes of maternal death...
  54. doi Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population
    Carolina A Ponce
    Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina Universidad de Chile, and 2Servicio Médico Legal, Santiago, Chile
    Clin Infect Dis 50:347-53. 2010
    ..However, studies searching for Pneumocystis in the autopsied lungs of healthy immunocompetent adults have not met with success...
  55. doi Autopsy reports in extreme longevity
    M Motta
    Department of Senescence Sciences, University of Catania, Cannizzaro Hospital, Via Messina, 829, I 95126 Catania, Italy
    Arch Gerontol Geriatr 50:48-50. 2010
    ..The autopsy findings of 140 centenarians (21 males and 119 females) of the age range of 100-109 years were compared to those ..
  56. doi High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: a path analysis using a large number of autopsy cases
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi, Tokyo 173 0015, Japan
    Heart 95:1997-2002. 2009
    ..To investigate whether hyper-lipoproteinaemia(a) (Lp(a)) promotes coronary atherosclerosis, acute thrombosis resulting in myocardial infarction (MI), or both...
  57. ncbi PKP2 mutations in sudden death from arrhythmogenic right ventricular cardiomyopathy (ARVC) and sudden unexpected death with negative autopsy (SUDNA)
    Mingchang Zhang
    Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai, China
    Circ J 76:189-94. 2012
    ..Fatal arrhythmias resulting in sudden death also occur in the absence of morphologic cardiac abnormalities at autopsy, and have been linked to ion channel mutations in a subset of cases, but so far not to PKP2.
  58. pmc Sample registration of vital events with verbal autopsy: a renewed commitment to measuring and monitoring vital statistics
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA
    Bull World Health Organ 83:611-7. 2005
    ..Sample vital registration (SVR), when applied in conjunction with validated verbal autopsy procedures and implemented in a nationally representative sample of population clusters represents an affordable, ..
  59. doi Sudden cardiac death with normal heart: molecular autopsy
    Cristina Basso
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padua Medical School, Padua, Italy
    Cardiovasc Pathol 19:321-5. 2010
    ..For these reasons, autopsy investigation of cardiac SD should always include sampling for genetic testing to search for the invisible ..
  60. doi Burial surveillance detected significant reduction in HIV--related deaths in Addis Ababa, Ethiopia
    Tekebash Araya
    School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 16:1483-9. 2011
    To determine the level of HIV-related mortality reduction after the introduction of large-scale antiretroviral therapy (ART) using a burial surveillance system coupled with verbal autopsy (VA) in Addis Ababa, Ethiopia.
  61. pmc Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies
    Brittany N Dugger
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Mov Disord 27:72-8. 2012
    ..Women with autopsy-confirmed DLB without a history of dream enactment behavior during sleep had a later onset of hallucinations and ..
  62. doi Venous congestive myelopathy: three autopsy cases showing a variety of clinicopathologic features
    Koushun Matsuo
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 28:303-8. 2008
    We describe three patients with progressive myelopathy, in whom autopsy revealed spinal cord pathology compatible with that of venous congestive myelopathy (VCM) associated with dural arteriovenous fistula (AVF), formerly known as ..
  63. ncbi Guidelines for autopsy investigation of sudden cardiac death
    Cristina Basso
    Pathological Anatomy, Department of Medical Diagnostic Sciences and Special Therapies, University of Padua Medical School, Padua, Italy
    Virchows Arch 452:11-8. 2008
    ..Pathology developed guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate assessment of sudden cardiac death, including not only a protocol for heart examination ..
  64. ncbi Switching benchmarks in cancer of unknown primary: from autopsy to microarray
    George Pentheroudakis
    Department of Medical Oncology, Ioannina University Hospital, Niarxou Avenue, 45500 Ioannina, Greece
    Eur J Cancer 43:2026-36. 2007
    ..We systematically reviewed all published evidence on the CUP primary site identified by two different approaches, either autopsy or microarray gene expression profiling.
  65. pmc Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases
    Koichi Fujimoto
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Med Genet 11:159. 2010
    ..Whether they are associated with emphysema is not known...
  66. pmc Metabolomic changes in autopsy-confirmed Alzheimer's disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 7:309-17. 2011
    ....
  67. doi Distribution of biventricular disease in arrhythmogenic cardiomyopathy: an autopsy study
    Fabio Tavora
    Department of Pathology, Escola Paulista de Medicina, UNIFESP, São Paulo 04023 900, Brazil
    Hum Pathol 43:592-6. 2012
    ..It is a major cause of sudden death in the young and in athletes. There are few autopsy studies of the ventricular distribution of the disease...
  68. doi Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection
    Noriko Nakajima
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    Mod Pathol 25:1-13. 2012
    Twenty autopsy cases with 2009 pandemic influenza A (2009 H1N1) virus infection, performed between August 2009 and February 2010, were histopathologically analyzed...
  69. pmc Probabilistic methods for verbal autopsy interpretation: InterVA robustness in relation to variations in a priori probabilities
    Edward Fottrell
    Department of Public Health and Clinical Medicine, Umeå Centre for Global Health Research, Umea University, Umea, Sweden
    PLoS ONE 6:e27200. 2011
    InterVA is a probabilistic method for interpreting verbal autopsy (VA) data...
  70. pmc Longitudinal decline in autopsy-defined frontotemporal lobar degeneration
    M Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neurology 70:2036-45. 2008
    ..The natural history of patients with pathologically proven frontotemporal lobar degeneration (FTLD) is important from clinical and biologic perspectives, but is not well documented quantitatively...
  71. ncbi Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
    G Danscher
    Department of Neurobiology, University of Aarhus, Denmark
    J Neurosci Methods 76:53-9. 1997
    ..We hypothesise that the increased zinc level is caused by an increase in the amount of ZEN terminals. Such an increase could be the result of a sprout of ZEN terminals in diseased areas of the brain...
  72. ncbi Prevalence of papillary microcarcinoma of the thyroid in Brazilian autopsy and surgical series
    Patricia Sabino de Matos
    Department of Pathology, School of Medicine FCM, State University of Campinas, Sao Paulo, Brazil
    Endocr Pathol 17:165-73. 2006
    ..Both genders were similarly affected: 9.3% of the men and 8.8% of the women in autopsy series, and 6.2% of the men and 7...
  73. doi Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit
    Ruben Gomez
    Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 208:348-54. 2009
    ..Approximately 5% of combat-related injuries include burns. Previous studies have shown similar mortality rates between military and civilian burn casualties; but causes of death were not detailed...
  74. doi Potential indications for ovarian autotransplantation based on the analysis of 5,571 autopsy findings of females under the age of 40 in Japan
    Koichi Kyono
    Kyono ART Clinic, Miyagi, Japan
    Fertil Steril 93:2429-30. 2010
    ....
  75. pmc Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California San Francisco, CA 94143 1207, USA
    Arch Neurol 69:509-17. 2012
    ..Deficits in the generation and control of saccades have been described in clinically defined frontotemporal dementia (FTD) and Alzheimer disease (AD)...
  76. ncbi Neuropathology and general autopsy findings in nondemented aged subjects
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    Clin Neuropathol 31:87-98. 2012
    ..General autopsy revealed severe systemic and coronary atherosclerosis in 86 and 90%, respectively, renal angioangiolosclerosis in ..
  77. pmc The relation between inflammation and neurodegeneration in multiple sclerosis brains
    Josa M Frischer
    Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Wien, Austria
    Brain 132:1175-89. 2009
    ..It further indicates that the disease processes of multiple sclerosis may die out in aged patients with long-standing disease...
  78. doi Housekeepers for accurate transcript expression analysis in Alzheimer's disease autopsy brain tissue
    Florian M Gebhardt
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
    Alzheimers Dement 6:465-74. 2010
    ..Alzheimer's disease (AD) alters brain metabolism. The stability of housekeeper transcript expression must be carefully validated...
  79. doi Morphological and flow cytometric analysis of cell infiltration in glioblastoma: a comparison of autopsy brain and neuroimaging
    Takahiro Yamahara
    Department of Neurosurgery, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka, 570 8507, Japan
    Brain Tumor Pathol 27:81-7. 2010
    ..We examined seven autopsy brains, focusing on tumor cell infiltration in the peripheral zone of a tumor, and compared our findings with the ..
  80. doi Cocaine-related sudden death: a prospective investigation in south-west Spain
    Joaquin Lucena
    Forensic Pathology Service, Institute of Legal Medicine, Seville, Spain
    Eur Heart J 31:318-29. 2010
    ..The aim of this study was to examine a consecutive series of sudden deaths (SDs) to focus on the prevalence, the toxicological characteristics, and the causes of death in COC-related fatalities...
  81. doi Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
    ..This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit ..
  82. ncbi An autopsy case of pseudoxanthoma elasticum: histochemical characteristics
    Katsuaki Miki
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Med Mol Morphol 40:172-7. 2007
    An autopsy case of pseudoxanthoma elasticum is reported. A Japanese female patient complained of yellow papules on the neck, precordium, and axilla, beginning at 54 years of age...
  83. doi Recent trends in the prevalence of coronary disease: a population-based autopsy study of nonnatural deaths
    Peter N Nemetz
    Sauder School of Business, University of British Columbia, Vancouver, British Columbia, Canada
    Arch Intern Med 168:264-70. 2008
    ..Despite increases in obesity and diabetes mellitus, mortality caused by coronary disease continues to decline. Recent trends in coronary disease prevalence are unknown...
  84. ncbi The prevalence of prostate carcinoma and its precursor in Hungary: an autopsy study
    Gyorgyike Soos
    Department of Pathology, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary
    Eur Urol 48:739-44. 2005
    ..incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United ..
  85. pmc Clinical review: What is the role for autopsy in the ICU?
    Greet Yvonne Agnes De Vlieger
    Department of General Internal Medicine, Medical Intensive Care Unit, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Crit Care 14:221. 2010
    ..Moreover, intensivists may wrongly believe that autopsy findings do not contribute to the understanding of pathophysiological events...
  86. doi Alkaptonuria--a review of surgical and autopsy pathology
    T R Helliwell
    Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool, UK
    Histopathology 53:503-12. 2008
    ..the macroscopic and histopathological changes in the tissues in alkaptonuria are illustrated by the detailed autopsy study of a 74-year-old female who died from disseminated ovarian carcinoma...
  87. pmc Colloid cyst of the third ventricle, hypothalamus, and heart: a dangerous link for sudden death
    Emanuela Turillazzi
    Department of Forensic Pathology, University of Foggia, Foggia, Italy
    Diagn Pathol 7:144. 2012
    ....
  88. doi Autopsies in HIV: still identifying missed diagnoses
    M B J Beadsworth
    Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK
    Int J STD AIDS 20:84-6. 2009
    ..The commonest diagnosis pre- and post-autopsy diagnosis was pneumonia...
  89. ncbi Mental illness and accidental death. Case-control psychological autopsy study
    Susan S F Gau
    Department of Psychiatry, College of Medicine, National Taiwan Univeristy and National Taiwan University Hospital, Taipei, Taiwan
    Br J Psychiatry 185:422-8. 2004
    ..Few studies have systematically investigated the psychiatric antecedents of accidental death...
  90. ncbi Accuracy of clinical diagnosis of acute respiratory distress syndrome in comparison with autopsy findings
    Bruno Valle Pinheiro
    Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil
    J Bras Pneumol 33:423-8. 2007
    To compare the American-European Consensus Conference (AECC) definition of acute respiratory distress syndrome (ARDS) to autopsy findings.
  91. ncbi Gender gap, inflammation and acute coronary disease: are women resistant to atheroma growth? Observations at autopsy
    Richard J Frink
    Heart Research Foundation of Sacramento, 1007 39th Street, Sacramento, CA 95816 5502, USA
    J Invasive Cardiol 21:270-7. 2009
    ..We sought to determine if these differences could be related to differences in the pathologic substrate found in the coronary arteries at the time of death...
  92. ncbi Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Atheroscler Thromb 16:91-104. 2009
    ..We attempted to explore interactions between smoking and the genetic polymorphism of 24 atherosclerosis-related candidate genes in systemic atherosclerosis...
  93. ncbi Comparison of the incidence of latent prostate cancer detected at autopsy before and after the prostate specific antigen era
    Badrinath R Konety
    Department of Urology, University of Iowa, Iowa City, Iowa 52242, USA
    J Urol 174:1785-8; discussion 1788. 2005
    Most data regarding the prevalence of latent prostate cancer found only at autopsy are from old reports...
  94. pmc Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue--implications for MRI studies of human autopsy samples
    Timothy M Shepherd
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Neuroimage 44:820-6. 2009
    High-resolution imaging of human autopsy tissues may improve our understanding of in vivo MRI findings, but interpretation is complicated because samples are obtained by immersion fixation following a postmortem interval (PMI)...
  95. pmc Comparison between clinical and autopsy diagnoses in a cardiology hospital
    Rafael Saad
    Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    Heart 93:1414-9. 2007
    A few recent studies have evaluated diagnostic accuracy by comparison between clinical and autopsy diagnoses in a hospital specialising in cardiology.
  96. ncbi Pulmonary histopathological alterations in patients with acute respiratory failure: an autopsy study
    Alexandre de Matos Soeiro
    Faculdade de Medicina da Universidade de Sao Paulo FMUSP, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Bras Pneumol 34:67-73. 2008
    ....
  97. ncbi The first autopsy case of pandemic influenza (A/H1N1pdm) virus infection in Japan: detection of a high copy number of the virus in type II alveolar epithelial cells by pathological and virological examination
    Noriko Nakajima
    Department of Pathology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    Jpn J Infect Dis 63:67-71. 2010
    We report the pathological and virological findings of the first autopsy case of the 2009 pandemic influenza (A/H1N1pdm) virus infection in Japan...
  98. pmc Autopsy after termination of pregnancy for fetal anomaly: retrospective cohort study
    P A Boyd
    National Perinatal Epidemiology Unit, Institute of Health Sciences, Headington, Oxford OX3 7LF
    BMJ 328:137. 2004
    To study trends in termination of pregnancy for fetal anomaly over 10 years and to assess the contribution of autopsy to the final diagnosis and counselling after termination.
  99. ncbi Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time
    Susan Morgello
    Manhattan HIV Brain Bank, Department of Pathology, Division of Neuropathology, The Mount Sinai Medical Center, 1 Gustave L Levy Pl, New York, NY 10029, USA
    Arch Pathol Lab Med 126:182-90. 2002
    To examine autopsy pathology in an urban population infected with the human immunodeficiency virus (HIV) and to determine if age at death and disease frequencies are associated with gender, HIV risk factors, ethnicity, and therapeutic era.
  100. ncbi Pulmonary pathology in patients with AIDS: an autopsy study from Mumbai
    D N Lanjewar
    Department of Pathology, Grant Medical College, and Sir JJ Hospital, Mumbai, India
    HIV Med 2:266-71. 2001
    ..Hence, an autopsy study was carried out to analyse the spectrum of pulmonary lesions in patients with HIV/AIDS.
  101. ncbi Correlation between surgical lung biopsy and autopsy findings and clinical data in patients with diffuse pulmonary infiltrates and acute respiratory failure
    Mauro Canzian
    Division of Respiratory Diseases, Heart Institute, Sao Paulo University Medical School, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 61:425-32. 2006
    ..Surgical lung biopsy is an invasive procedure performed when other procedures have failed to provide an urgent and specific diagnosis, but there may be reluctance to perform it in critically ill patients with diffuse pulmonary infiltrates...

Research Grants91

  1. Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and Dementia
    Gary Small; Fiscal Year: 2009
    b>Autopsy studies have shown that middle-aged adults with Down's syndrome (DS) exhibit the neuropathological hallmarks of Alzheimer's disease (AD): amyloid senile plaques (SPs) and tau neurofibrillary tangles (NFTs)...
  2. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2010
    ..It is also unlikely that human autopsy tissues are suitable for the direct determination of this small pool of highly reactive iron...
  3. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2010
    ..Braak and his colleagues reported that the youngest individuals in their large autopsy series showed pathological changes of PD only in the enteric nervous system (ENS), while PD pathology in the CNS ..
  4. Genetic and Transcriptional Control of Spleen Development
    Licia Selleri; Fiscal Year: 2010
    ..blood filtering and its absence (as in congenital asplenia, an under-diagnosed disorder often recognized only at autopsy) results in a high risk for life-threatening bacterial infections in newborns and children...
  5. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2010
    ..Atherosclerosis primarily affects large and medium sized vessels with autopsy data demonstrating that the abdominal aorta offers a valuable early window for the study of atherosclerosis...
  6. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..same clinical course as those in the blind trial? 4) Do transplant effects plateau and then decline? and 5) At autopsy, does the survival of dopamine cells and accompanying neurite outgrowth correlate with clinical and PET scan ..
  7. True Direct Single Molecule RNA Sequencing
    PATRICE MARIE MILOS; Fiscal Year: 2010
    ..from fragmented RNA samples, and 4) sequence analysis of archival influenza virus genomes from circa 1918 autopsy tissues. Specific Aim 3...
  8. Stroke and aPL: Community-Based Clinicopathological Study
    Steven Levine; Fiscal Year: 2009
    ..compare multiple to single aPL positivity, and to assess mechanisms of aPL associated cerebrovascular disease at autopsy. The proposed study will take advantage of ante-mortem biologic specimens, clinical and post-mortem data from two ..
  9. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2010
    ..compare multiple to single aPL positivity, and to assess mechanisms of aPL associated cerebrovascular disease at autopsy. The proposed study will take advantage of ante-mortem biologic specimens, clinical and post-mortem data from two ..
  10. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2007
    ..Data from our autopsy-based study suggest that this standard clinical case definition is wrong 23% of the time (62)...
  11. Culture, Risk Factors and Suicide Attempt in Rural China
    Jie Zhang; Fiscal Year: 2011
    ..g. the value systems) in determining risk for suicide. Psychological autopsy (PA) studies with suicides are usually limited by their indirect evaluation and understanding of the suicides&..
  12. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2009
    ..We propose to examine neurogenesis in MDD patients, with and without ADT, compared to normal healthy controls, evaluating whether neurogenesis is reduced in MDD and restored by ADT. ..
  13. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
    ..b>Autopsy incidence of Wernicke's encephalopathy (WE) associated lesions, undetected in life, suggests an under ..
  14. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2007
    ..b>Autopsy incidence of Wernicke's encephalopathy (WE) associated lesions, undetected in life, suggests an under ..
  15. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..b>Autopsy incidence of Wernicke's encephalopathy (WE) associated lesions, undetected in life, suggests an under ..
  16. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..b>Autopsy incidence of Wernicke's encephalopathy (WE) associated lesions, undetected in life, suggests an ..
  17. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
    ..b>Autopsy incidence of Wernicke's encephalopathy (WE) associated lesions, undetected in life, suggests an under ..
  18. Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and Dementia
    GARY WILLIAM SMALL; Fiscal Year: 2010
    b>Autopsy studies have shown that middle-aged adults with Down's syndrome (DS) exhibit the neuropathological hallmarks of Alzheimer's disease (AD): amyloid senile plaques (SPs) and tau neurofibrillary tangles (NFTs)...
  19. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony de Leon; Fiscal Year: 2009
    ..HIP MRglc sampling accurately predicted the conversion of NL to MCI and to autopsy confirmed AD. However, MRglc measures lack pathological specificity for AD...
  20. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony J de Leon; Fiscal Year: 2010
    ..HIP MRglc sampling accurately predicted the conversion of NL to MCI and to autopsy confirmed AD. However, MRglc measures lack pathological specificity for AD...
  21. Causes of early mortality in HIV-infected Africans on antiretroviral therapy
    Abraham Siika; Fiscal Year: 2009
    ..where very sick AMPATH- enrolled patients are admitted; (2) the MTRH Morgue which has cold storage facilities, an autopsy laboratory and 4 full-time pathologists; (3) the AMPATH Medical Record System (AMRS), a fully computerized system ..
  22. Causes of early mortality in HIV-infected Africans on antiretroviral therapy
    ABRAHAM MOSIGISI SIIKA; Fiscal Year: 2010
    ..where very sick AMPATH- enrolled patients are admitted;(2) the MTRH Morgue which has cold storage facilities, an autopsy laboratory and 4 full-time pathologists;(3) the AMPATH Medical Record System (AMRS), a fully computerized system ..
  23. Causes of early mortality in HIV-infected Africans on antiretroviral therapy
    ABRAHAM MOSIGISI SIIKA; Fiscal Year: 2010
    ..where very sick AMPATH- enrolled patients are admitted;(2) the MTRH Morgue which has cold storage facilities, an autopsy laboratory and 4 full-time pathologists;(3) the AMPATH Medical Record System (AMRS), a fully computerized system ..
  24. Mechanisms of Multiple Sclerosis Tissue Pathology
    Claudia Lucchinetti; Fiscal Year: 2010
    ..Our prior funded research focused on early biopsy and autopsy MS cases and revealed CDM occurs early;can be inflammatory;and meningeal inflammation is prominent...
  25. Mechanisms of Multiple Sclerosis Tissue Pathology
    Claudia Lucchinetti; Fiscal Year: 2009
    ..Our prior funded research focused on early biopsy and autopsy MS cases and revealed CDM occurs early; can be inflammatory; and meningeal inflammation is prominent...
  26. TYPE II COLLAGEN DENATURATION IN AGING AND OSTEOARTHRITI
    Anthony Poole; Fiscal Year: 2003
    ..We will examine aging human knee articular cartilages from autopsy and OA cartilages at arthroplasty, and those from the talus (ankle) (autopsy only)...
  27. Neurovascular Mechanisns of Brain Function and Disease
    Philip Liu; Fiscal Year: 2007
    ..Currently, most detection techniques of gene transcription require biopsy or autopsy samples...
  28. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..of John Allman and Barbara Wold to investigate gene expression in laser micro-dissected cell populations in autopsy brains of well-phenotyped autistic individuals versus age and sex matched controls using a recently developed ..
  29. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    John Allman; Fiscal Year: 2009
    ..of John Allman and Barbara Wold to investigate gene expression in laser micro-dissected cell populations in autopsy brains of well-phenotyped autistic individuals versus age and sex matched controls using a recently developed ..
  30. Metabolic Engineering for Improved Liver Function
    Martin Yarmush; Fiscal Year: 2009
    ..The incidence of hepatic steatosis is 10 to 25% based on autopsy studies and donor liver biopsies...
  31. Metabolic Engineering for Improved Liver Function
    Martin Yarmush; Fiscal Year: 2009
    ..The incidence of hepatic steatosis is 10 to 25% based on autopsy studies and donor liver biopsies...
  32. CLINICOPATHOLOGICAL CORRELATES OF CEREBRAL MALARIA
    Terrie Taylor; Fiscal Year: 1999
    ..vitro models mimics the human disease adequately, and the most valuable information on pathogenesis has come from autopsy studies of adults. However, 90% of malaria-associated mortality occurs in African children...
  33. Scaling and Sequencing Motor Output in Humans: fMRI Study
    David E Vaillancourt; Fiscal Year: 2010
    ..Second, although degeneration in the substantia nigra can be used to confirm PD at autopsy, there is limited knowledge in living humans linking structural degeneration in the substantia nigra with ..
  34. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2010
    ..The molecular mechanisms in SSA remain undefined, but are important to determine as autopsy studies have suggested that heart failure caused by amyloidosis may be vastly unrecognized and undiagnosed in the ..
  35. Characterizing the Behavior Profile of Healthy Cognitive Aging
    Patricia Boyle; Fiscal Year: 2009
    ..However, the vast majority of persons without dementia who come to autopsy have extensive neuropathologic evidence of the diseases commonly known to cause cognitive impairment in old age, ..
  36. SIV Encephalitis and Disease Progression
    Clayton Wiley; Fiscal Year: 2009
    ..In Specific Aim 3 we will measure synaptic and extracellular matrix damage in autopsy brain tissues and compare them to the temporal course of peripheral and central viral loads, DAA1106 binding...
  37. BRAIN TISSUE RESOURCE CENTER FOR ALCOHOL RESEARCH
    Clive Harper; Fiscal Year: 2002
    ..new techniques have been developed in histology and molecular biology that can be applied to human post-mortem (autopsy) brain tissue...
  38. MECHANISMS OF ACTIONS OF ALCOHOL AND OMEGA 3-FATTY ACIDS
    Raj Lakshman; Fiscal Year: 2004
    ..2. Both 2,6-ST-mRNA and GAPDH mRNA levels seemed to be intact in two autopsy liver samples from non-alcoholic controls. 3...