autopsy

Summary

Summary: Postmortem examination of the body.

Top Publications

  1. pmc Revising the WHO verbal autopsy instrument to facilitate routine cause-of-death monitoring
    Jordana Leitao
    Disease Control and Vector Biology, London School of Hygiene and Tropical Medicine, London, UK
    Glob Health Action 6:21518. 2013
  2. pmc TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
    Michael A Gitcho
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Acta Neuropathol 118:633-45. 2009
  3. doi Verbal autopsy: methods in transition
    Edward Fottrell
    Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Epidemiol Rev 32:38-55. 2010
  4. pmc Verbal autopsy: current practices and challenges
    Nadia Soleman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 84:239-45. 2006
  5. ncbi Validation and application of verbal autopsies in a rural area of South Africa
    K Kahn
    Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 5:824-31. 2000
  6. pmc Strengthening standardised interpretation of verbal autopsy data: the new InterVA-4 tool
    Peter Byass
    Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Glob Health Action 5:1-8. 2012
  7. pmc Refining a probabilistic model for interpreting verbal autopsy data
    Peter Byass
    Umeå International School of Public Health, Umea University, Umea, Sweden
    Scand J Public Health 34:26-31. 2006
  8. ncbi Validity of verbal autopsy procedures for determining cause of death in Tanzania
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Trop Med Int Health 11:681-96. 2006
  9. doi Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
  10. ncbi Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses
    Janneke A Cox
    Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Rev 12:183-94. 2010

Detail Information

Publications401 found, 100 shown here

  1. pmc Revising the WHO verbal autopsy instrument to facilitate routine cause-of-death monitoring
    Jordana Leitao
    Disease Control and Vector Biology, London School of Hygiene and Tropical Medicine, London, UK
    Glob Health Action 6:21518. 2013
    Verbal autopsy (VA) is a systematic approach for determining causes of death (CoD) in populations without routine medical certification. It has mainly been used in research contexts and involved relatively lengthy interviews...
  2. pmc TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
    Michael A Gitcho
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Acta Neuropathol 118:633-45. 2009
    ..Since that study, brain tissue has become available and provides autopsy confirmation of FTLD-TDP in the proband and ALS in the brother of the bvFTD-ALS family and the neuropathology of ..
  3. doi Verbal autopsy: methods in transition
    Edward Fottrell
    Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Epidemiol Rev 32:38-55. 2010
    ..In the absence of routine death registration, verbal autopsy (VA) methods are used to derive probable causes of death...
  4. pmc Verbal autopsy: current practices and challenges
    Nadia Soleman
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 84:239-45. 2006
    Cause-of-death data derived from verbal autopsy (VA) are increasingly used for health planning, priority setting, monitoring and evaluation in countries with incomplete or no vital registration systems...
  5. ncbi Validation and application of verbal autopsies in a rural area of South Africa
    K Kahn
    Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 5:824-31. 2000
    To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in the Agincourt subdistrict of rural South Africa.
  6. pmc Strengthening standardised interpretation of verbal autopsy data: the new InterVA-4 tool
    Peter Byass
    Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Glob Health Action 5:1-8. 2012
    Verbal autopsy (VA) is the only available approach for determining the cause of many deaths, where routine certification is not in place...
  7. pmc Refining a probabilistic model for interpreting verbal autopsy data
    Peter Byass
    Umeå International School of Public Health, Umea University, Umea, Sweden
    Scand J Public Health 34:26-31. 2006
    To build on the previously reported development of a Bayesian probabilistic model for interpreting verbal autopsy (VA) data, attempting to improve the model's performance in determining cause of death and to reassess it.
  8. ncbi Validity of verbal autopsy procedures for determining cause of death in Tanzania
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Trop Med Int Health 11:681-96. 2006
    To validate verbal autopsy (VA) procedures for use in sample vital registration...
  9. doi Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
    ..This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit ..
  10. ncbi Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses
    Janneke A Cox
    Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Rev 12:183-94. 2010
    ..Pathological autopsies are the gold standard to establish causes of death. In this review we describe the autopsy series performed among HIV-infected individuals in sub-Saharan Africa over the last two decades...
  11. pmc Verbal autopsy coding: are multiple coders better than one?
    Rohina Joshi
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Bull World Health Organ 87:51-7. 2009
    To assess the impact on the reported cause-of-death patterns of a verbal autopsy coding strategy based on a review of every death by multiple coders versus a single coder.
  12. pmc Moving from data on deaths to public health policy in Agincourt, South Africa: approaches to analysing and understanding verbal autopsy findings
    Peter Byass
    Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umea University, Sweden
    PLoS Med 7:e1000325. 2010
    ..Interviewing family and friends after a death has occurred (a procedure known as verbal autopsy) provides a source of data where deaths otherwise go unregistered; but sound methods for interpreting and ..
  13. pmc Sample registration of vital events with verbal autopsy: a renewed commitment to measuring and monitoring vital statistics
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA
    Bull World Health Organ 83:611-7. 2005
    ..Sample vital registration (SVR), when applied in conjunction with validated verbal autopsy procedures and implemented in a nationally representative sample of population clusters represents an affordable, ..
  14. pmc Post-mortem imaging as an alternative to autopsy in the diagnosis of adult deaths: a validation study
    Ian S D Roberts
    Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK
    Lancet 379:136-42. 2012
    Public objection to autopsy has led to a search for minimally invasive alternatives. Imaging has potential, but its accuracy is unknown...
  15. doi Cause of death distribution with InterVA and physician coding in a rural area of Burkina Faso
    Heribert Ramroth
    Institute of Public Health, University Hospital of Heidelberg, Heidelberg, Germany
    Trop Med Int Health 17:904-13. 2012
    To compare the cause of death distribution using the Physician Coded Verbal Autopsy approach versus the Interpreting Verbal Autopsy model, based on information from a French verbal autopsy questionnaire, in rural north-western Burkina ..
  16. pmc Factors associated with physician agreement on verbal autopsy of over 27000 childhood deaths in India
    Shaun K Morris
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    PLoS ONE 5:e9583. 2010
    ..The large majority of these deaths occur in the developing world. The verbal autopsy (VA) is a tool designed to ascertain cause of death in such settings...
  17. ncbi Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
    Rajal B Shah
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Cancer Res 64:9209-16. 2004
    ..Hierarchical clustering of 16 rapid autopsy tumor samples was performed to evaluate the cDNA expression pattern associated with the morphology...
  18. pmc Assessing a new approach to verbal autopsy interpretation in a rural Ethiopian community: the InterVA model
    Mesganaw Fantahun
    Department of Community Health, Addis Ababa University, Ethiopia
    Bull World Health Organ 84:204-10. 2006
    Verbal autopsy (VA) -- the interviewing of family members or caregivers about the circumstances of a death after the event -- is an established tool in areas where routine death registration is non-existent or inadequate...
  19. doi Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns
    Hyang Min Byun
    Jane Anne Nohl Division of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 18:4808-17. 2009
    ..05). Finally, we found that the Illumina GoldenGate assay features a large number of probes (265/1505 probes, 17.6%) that contain single-nucleotide polymorphisms, which may interfere with DNA methylation analyses in genome-wide studies...
  20. pmc Setting international standards for verbal autopsy
    Frank Baiden
    Bull World Health Organ 85:570-1. 2007
  21. doi The autopsy: knowledge, attitude, and perceptions of doctors and relatives of the deceased
    Olayiwola Abideen Oluwasola
    Department of Pathology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Oyo State, Nigeria
    Arch Pathol Lab Med 133:78-82. 2009
    Despite the crucial role that autopsy plays in the development of the science and practice of medicine, autopsy rates have been declining throughout the world in recent decades.
  22. ncbi Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study
    Neil A Martinson
    Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA
    AIDS 21:2043-50. 2007
    ..To ascertain the immediate and underlying causes of death in adults who died in hospital with a premortem diagnosis of tuberculosis...
  23. doi Impact of employment status and work-related factors on risk of completed suicide. A case-control psychological autopsy study
    Barbara Schneider
    Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, Goethe University, Frankfurt Main, Germany
    Psychiatry Res 190:265-70. 2011
    ..factors including work-related factors were assessed by a semi-structured interview using the psychological autopsy method in 163 completed suicide cases and by personal interview in 396 living population-based control persons...
  24. pmc Metabolomic changes in autopsy-confirmed Alzheimer's disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 7:309-17. 2011
    ....
  25. pmc Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests
    Valeria Iodice
    Neurovascular and Autonomic Medicine Unit, Imperial College London, UK
    J Neurol Neurosurg Psychiatry 83:453-9. 2012
    ..Published autopsy confirmed cases have provided reasonable neurological characterisation but have lacked adequate autonomic ..
  26. pmc An autopsy study describing causes of death and comparing clinico-pathological findings among hospitalized patients in Kampala, Uganda
    Janneke A Cox
    Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 7:e33685. 2012
    ..of death in HIV-infected patients in Sub-Saharan Africa is mainly derived from observational cohort and verbal autopsy studies. Autopsy is the gold standard to ascertain cause of death...
  27. doi Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study
    Sudhin Thayyil
    Centre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London UCL, London, UK
    Lancet 382:223-33. 2013
    Post-mortem MRI is a potential diagnostic alternative to conventional autopsy, but few large prospective studies have compared its accuracy with that of conventional autopsy...
  28. pmc Validating the InterVA model to estimate the burden of mortality from verbal autopsy data: a population-based cross-sectional study
    Sebsibe Tadesse
    Institute of Public Health, The University of Gondar, Gondar, Ethiopia
    PLoS ONE 8:e73463. 2013
    In countries with incomplete or no vital registration systems, verbal autopsy data are often reviewed by physicians in order to assign the probable cause of death...
  29. doi Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy
    Arnaud W Thille
    Departamento de Cuidados Intensivos, Hospital Universitario de Getafe, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Spain
    Am J Respir Crit Care Med 187:761-7. 2013
    ..A revised definition of clinical criteria for acute respiratory distress syndrome (ARDS), the Berlin definition, was recently established to classify patients according to their severity...
  30. ncbi Neuropathology and general autopsy findings in nondemented aged subjects
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Vienna, Austria
    Clin Neuropathol 31:87-98. 2012
    ..General autopsy revealed severe systemic and coronary atherosclerosis in 86 and 90%, respectively, renal angioangiolosclerosis in ..
  31. ncbi Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998
    N A Ansari
    The BOTUSA Project, Gaborone, Botswana
    Int J Tuberc Lung Dis 6:55-63. 2002
    ..Little is known about causes of death in countries of southern Africa seriously affected by the HIV/AIDS epidemic...
  32. ncbi Validation of verbal autopsy procedures for adult deaths in China
    Gonghuan Yang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 5, Dong Dan San Tiao, 100005 Beijing, China
    Int J Epidemiol 35:741-8. 2006
    ..Information on the leading causes of mortality will continue to rely on verbal autopsy (VA) methods...
  33. ncbi Understanding the unique characteristics of suicide in China: national psychological autopsy study
    Gong Huan Yang
    Chinese Academy of Preventive Medicine, Beijing, China
    Biomed Environ Sci 18:379-89. 2005
    ..To compare the characteristics of suicides in the four main demographic groups: urban males, urban females, rural males and rural females in order to help clarify the demographic pattern of suicides in China...
  34. ncbi Post-mortem findings in harbour porpoises (Phocoena phocoena) from the German North and Baltic Seas
    U Siebert
    , , Frankfurter Strasse 96, 35392 Giessen, Germany
    J Comp Pathol 124:102-14. 2001
    ..Beta-haemolytic streptococci were considered to be the main infectious agents. Morbillivirus antigen was not detected immunohistochemically...
  35. ncbi Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p)reactive lesions
    C J De Groot
    Department of Pathology, MS Centre for Research and Care MSCRC, Vrije Universiteit Medical Centre and Netherlands Brain Bank, Amsterdam, The Netherlands
    Brain 124:1635-45. 2001
    ..The Netherlands Brain Bank organized the rapid autopsy of 29 multiple sclerosis patients. The brain was cut in 1 cm coronal slices...
  36. ncbi Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003)
    Georgios Chamilos
    Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, Laboratory Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Haematologica 91:986-9. 2006
    We evaluated autopsy-proven invasive fungal infections (IFI) in patients with hematologic malignancies over three periods (1989-1993, 1994-1998, and 1999-2003). The autopsy rate declined significantly (67%-34%-26%, respectively p<0...
  37. pmc Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, Institute on Ageing, Centre for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain 136:2697-706. 2013
    ....
  38. pmc Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa
    Biruk Tensou
    Addis Ababa Mortality Surveillance Project, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 15:547-53. 2010
    To evaluate the performance of a verbal autopsy (VA) expert algorithm (the InterVA model) for diagnosing AIDS mortality against a reference standard from hospital records that include HIV serostatus information in Addis Ababa, Ethiopia.
  39. pmc Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak
    Zong Mei Sheng
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:16416-21. 2011
    ..These findings have important implications for understanding the origins and evolution of pandemic influenza viruses...
  40. doi Prevalence of dementia disorders in the oldest-old: an autopsy study
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria
    Acta Neuropathol 119:421-33. 2010
    ..hospital-based study of the relative prevalence of different disorders was performed in 1,110 consecutive autopsy cases of demented elderly in Vienna, Austria (66% females, MMSE <20; mean age 83.3 +/- 5.4 SD years)...
  41. ncbi Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases
    H Kondo
    Dept of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan
    Endoscopy 33:507-10. 2001
    ..Of these, 347 were identified from a series of 6380 autopsy cases; 54 patients were diagnosed endoscopically while alive, 12 of whom had confirmation of the condition at ..
  42. ncbi Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan.
  43. ncbi Changes in rates of autopsy-detected diagnostic errors over time: a systematic review
    Kaveh G Shojania
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    JAMA 289:2849-56. 2003
    Substantial discrepanies exist between clinical diagnoses and findings at autopsy. Autopsy may be used as a tool for quality management to analyze diagnostic discrepanies.
  44. pmc Verbal autopsy of 80,000 adult deaths in Tamilnadu, South India
    Vendhan Gajalakshmi
    Epidemiological Research Center, Chennai, India
    BMC Public Health 4:47. 2004
    ..A special verbal autopsy (VA) study of 48,000 adult (aged >or= 25 yrs) deaths in the city of Chennai (urban) during 1995-97 and 32,000 ..
  45. pmc The worldwide epidemiology of prostate cancer: perspectives from autopsy studies
    Gabriel P Haas
    Department of Urology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Can J Urol 15:3866-71. 2008
    ..Prostate cancer is the most frequently diagnosed non-skin cancer in the United States and the third leading cause of cancer deaths. International trends in the incidence, mortality and prevalence of prostate cancer are assessed...
  46. pmc Diagnostic validity of fatal cerebral strokes and coronary deaths in mortality statistics: an autopsy study
    Anne K Gulsvik
    Department of Geriatric Medicine, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
    Eur J Epidemiol 26:221-8. 2011
    ..was assessed by using mortality data of participants in the Bergen Clinical Blood Pressure Study in Norway and autopsy records from the Gade Institute in Bergen...
  47. doi Less invasive autopsy: benefits and limitations of the use of magnetic resonance imaging in the perinatal postmortem
    Marta C Cohen
    Department of Histopathology, Sheffield Children s NHS Foundation Trust, Western Bank, Sheffield S10 2TH, United Kingdom
    Pediatr Dev Pathol 11:1-9. 2008
    The decline in the postmortem (PM) autopsy rate in the United Kingdom paralleled the change in public perception of this procedure after the organ retention crisis in 2000...
  48. doi Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit
    Ruben Gomez
    Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 208:348-54. 2009
    ..Approximately 5% of combat-related injuries include burns. Previous studies have shown similar mortality rates between military and civilian burn casualties; but causes of death were not detailed...
  49. ncbi Successful RNA extraction from various human postmortem tissues
    Marielle Heinrich
    Institute of Legal Medicine, University of Freiburg, Albertstr 9, 79104, Freiburg, Germany
    Int J Legal Med 121:136-42. 2007
    ....
  50. pmc The conventional autopsy in modern medicine
    Tariq Ayoub
    Foundation Year 1 F1, Conquest Hospital Hastings, UK
    J R Soc Med 101:177-81. 2008
    In many countries, including the UK, where relatives' consent is required, clinical autopsy rates (i.e. autopsies other than those required by law) have been declining since the 1950s...
  51. ncbi An autopsy case of pseudoxanthoma elasticum: histochemical characteristics
    Katsuaki Miki
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Med Mol Morphol 40:172-7. 2007
    An autopsy case of pseudoxanthoma elasticum is reported. A Japanese female patient complained of yellow papules on the neck, precordium, and axilla, beginning at 54 years of age...
  52. doi Declining autopsy rates and suicide misclassification: a cross-national analysis of 35 countries
    Nestor D Kapusta
    Department for Psychoanalysis and Psychotherapy, Medical University of Vienna, Austria
    Arch Gen Psychiatry 68:1050-7. 2011
    ..Suicides are prone to misclassification during death ascertainment procedures. This problem has generated frequent criticism of the validity of suicide mortality statistics...
  53. pmc Factors associated with physician agreement and coding choices of cause of death using verbal autopsies for 1130 maternal deaths in India
    Ann L Montgomery
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael Hospital, Toronto, Ontario, Canada
    PLoS ONE 7:e33075. 2012
    The Indian Sample Registration System (SRS) with verbal autopsy methods provides estimations of cause specific mortality for maternal deaths, where the majority of deaths occur at home, unregistered...
  54. doi Causes of death in rural adult population of North India (2002-2007), using verbal autopsy tool
    C Palanivel
    Department of Community Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, India
    Indian J Public Health 57:78-83. 2013
    ..Verbal autopsy (VA) is an established tool to ascertain the cause of death in areas where routine registration systems are ..
  55. doi Autopsy investigation and Bayesian approach to coronary artery disease in victims of motor-vehicle accidents
    Antonio Oliva
    Institute of Forensic Medicine, Catholic University, School of Medicine, Rome, Italy
    Atherosclerosis 218:28-32. 2011
    ..The aim of this study was to define the prevalence of coronary disease and its possible role in motor-vehicle accidents...
  56. doi Pneumocystis colonization is highly prevalent in the autopsied lungs of the general population
    Carolina A Ponce
    Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina Universidad de Chile, and 2Servicio Médico Legal, Santiago, Chile
    Clin Infect Dis 50:347-53. 2010
    ..However, studies searching for Pneumocystis in the autopsied lungs of healthy immunocompetent adults have not met with success...
  57. pmc Causes of community stillbirths and early neonatal deaths in low-income countries using verbal autopsy: an International, Multicenter Study
    C Engmann
    Division of Neonatal Perinatal Medicine, Department of Pediatric and Maternal Child Health, University of North Carolina Schools of Medicine and Public Health, Chapel Hill, NC 27599 7596, USA
    J Perinatol 32:585-92. 2012
    ..We used verbal autopsy (VA), to understand causes of non-hospital, community-based SB and END from four low-income countries.
  58. pmc Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death
    John R Giudicessi
    Division of Cardiovascular Diseases, Department of Medicine, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Hum Mutat 33:989-97. 2012
    ..Brugada syndrome (BrS) and idiopathic ventricular fibrillation (IVF), may serve as the pathogenic basis for autopsy-negative sudden unexplained death (SUD) and sudden infant death syndrome (SIDS)...
  59. doi Pathology and virology findings in cases of fatal influenza A H1N1 virus infection in 2009-2010
    Amanjit Bal
    Department of Histopathology, Post Graduate Institute of Medical Sciences and Research, Sector 12, Chandigarh, India
    Histopathology 60:326-35. 2012
    ....
  60. pmc Methodological trends in studies based on verbal autopsies before and after published guidelines
    Rohina Joshi
    George Institute for International Health, University of Sydney, Sydney NSW, Australia
    Bull World Health Organ 87:678-82. 2009
    To report on the uptake of guidelines published in the early 1990s with specific recommendations about the design of future studies based on verbal autopsy conducted for mortality surveillance.
  61. ncbi Applying verbal autopsy to determine cause of death in rural Vietnam
    Dao Lan Huong
    Health Strategy and Policy Institute, Ministry of Health, Hanoi, Vietnam
    Scand J Public Health Suppl 62:19-25. 2003
    Verbal autopsy (VA) is an attractive method for ascertaining causes of death in settings where the proportion of people who die under medical care is low...
  62. doi Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: an autopsy study
    Søren Dalager
    Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Skejby, Arhus, Denmark
    J Vasc Surg 47:296-302. 2008
    ..Assessment of subclinical atherosclerosis in peripheral arteries might improve this limitation. We studied the relationship between atherosclerotic plaques in peripheral arteries, coronary plaques, and coronary death...
  63. ncbi Childhood mortality and probable causes of death using verbal autopsy in Niakhar, Senegal, 1989-2000
    Jean Francois Etard
    Institut de Recherche pour le Développement IRD BP 1386 Dakar, Senegal
    Int J Epidemiol 33:1286-92. 2004
    ..The authors applied the verbal autopsy to identify causes of death before 15 years old in a rural area of Senegal where a demographic surveillance ..
  64. pmc Validity of verbal autopsy procedures for determining malaria deaths in different epidemiological settings in Uganda
    Arthur Mpimbaza
    Uganda Malaria Surveillance Project Kampala, Kampala, Uganda
    PLoS ONE 6:e26892. 2011
    Verbal autopsy (VA) procedures can be used to estimate cause of death in settings with inadequate vital registries...
  65. pmc Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner
    Karla L Miller
    FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Neuroimage 57:167-81. 2011
    ..Despite these alterations, diffusion tractography of several major tracts is successfully demonstrated at both resolutions. We also report novel findings of cortical anisotropy and partial volume effects...
  66. pmc Probabilistic methods for verbal autopsy interpretation: InterVA robustness in relation to variations in a priori probabilities
    Edward Fottrell
    Department of Public Health and Clinical Medicine, Umeå Centre for Global Health Research, Umea University, Umea, Sweden
    PLoS ONE 6:e27200. 2011
    InterVA is a probabilistic method for interpreting verbal autopsy (VA) data...
  67. doi Metastatic patterns of cancers: results from a large autopsy study
    Guy DiSibio
    Department of Pathology, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Arch Pathol Lab Med 132:931-9. 2008
    ..Many studies have addressed metastatic patterns seen among various cancers. No recent studies, however, provide quantitative analyses of such patterns arising from a broad range of cancers based primarily on postmortem tissue analyses...
  68. doi Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia
    Paul C Guest
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Psychoneuroendocrinology 36:1092-6. 2011
    ..This could have important implications for future biomarker discovery efforts and personalized medicine strategies based on patient stratification for the treatment of this debilitating disorder...
  69. pmc Voxel-based morphometry in autopsy proven PSP and CBD
    Keith A Josephs
    Department of Neurology Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 29:280-9. 2008
    The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending ..
  70. ncbi Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings
    Andres Esteban
    Hospital Universitario de Getafe, Madrid, Spain
    Ann Intern Med 141:440-5. 2004
    ..The American-European Consensus Conference definition for the acute respiratory distress syndrome (ARDS) has never been validated...
  71. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
    ..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior...
  72. pmc An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    PLoS Med 5:e44. 2008
    ..The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios...
  73. ncbi Clinical, educational, and epidemiological value of autopsy
    Julian L Burton
    Academic Unit of Pathology, School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Lancet 369:1471-80. 2007
    The autopsy is now often regarded as of marginal use in modern clinical practice...
  74. pmc Human postmortem tissue: what quality markers matter?
    Ana D Stan
    University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
    Brain Res 1123:1-11. 2006
    ..g., thawed tissue, surgical tissue), that yielded unexpected quality indicators. These data also suggest that cases whose source was a Medical Examiner's office represent high tissue quality...
  75. ncbi Vascular dementia in a population-based autopsy study
    David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Neurol 60:569-75. 2003
    ..The validity of the clinical diagnosis of vascular dementia (VaD) remains suboptimal...
  76. pmc Verbal autopsy: reliability and validity estimates for causes of death in the Golestan Cohort Study in Iran
    Hooman Khademi
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences Tehran, Iran
    PLoS ONE 5:e11183. 2010
    Verbal autopsy (VA) is one method to obtain valid estimates of causes of death in the absence of valid medical records...
  77. pmc Verbal autopsy can consistently measure AIDS mortality: a validation study in Tanzania and Zimbabwe
    B Lopman
    Imperial College, London, UK
    J Epidemiol Community Health 64:330-4. 2010
    Verbal autopsy is currently the only option for obtaining cause of death information in most populations with a widespread HIV/AIDS epidemic.
  78. ncbi Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital ZNA, Lindendreef 1, 2020 Antwerp, Belgium
    Neurobiol Aging 29:1143-59. 2008
    ..181 (P-tau(181P)) compared to clinical diagnosis, biomarker levels were determined in CSF samples from 100 autopsy-confirmed dementia and 100 control subjects...
  79. ncbi Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death
    D H Chace
    Neo Gen Screening, PO Box 219, Bridgeville, PA 15017, USA
    Clin Chem 47:1166-82. 2001
    ..Tandem mass spectrometry (MS/MS) may reveal disorders of fatty acid oxidation in deaths of previously unknown cause...
  80. pmc Validation of the symptom pattern method for analyzing verbal autopsy data
    Christopher J L Murray
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America
    PLoS Med 4:e327. 2007
    ..of reliable vital registration data, information collected after death from household members, called verbal autopsy (VA), is commonly used to study causes of death...
  81. pmc Culture, risk factors and suicide in rural China: a psychological autopsy case control study
    J Zhang
    Department of Sociology, State University of New York College at Buffalo, NY 14222, USA
    Acta Psychiatr Scand 110:430-7. 2004
    ..The current study examines the major risk factors and some cultural uniqueness related to Chinese rural suicide using a quantitative design...
  82. ncbi Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants
    Lon White
    Kuakini Medical Center, 846 S Hotel Street, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 977:9-23. 2002
    ..The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction...
  83. ncbi Validation of verbal autopsy to determine the cause of 137 neonatal deaths in Karachi, Pakistan
    David R Marsh
    Office of Health, Save the Children Federation US, Westport, CT, USA
    Paediatr Perinat Epidemiol 17:132-42. 2003
    Verbal autopsy (VA) aims to estimate a community's mortality experience in the absence of contact with formal registration or health care systems...
  84. ncbi Anomalies of asymmetry of pyramidal cell density and structure in dorsolateral prefrontal cortex in schizophrenia
    Thomas J Cullen
    Prince of Wales International Centre for SANE Research, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 188:26-31. 2006
    ..Studies suggest that neuronal density in left dorsolateral prefrontal cortex is increased in schizophrenia...
  85. pmc The molecular autopsy: should the evaluation continue after the funeral?
    David J Tester
    Division of Cardiovascular Diseases, Department of Medicine, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Guggenheim 501, Rochester, MN, USA
    Pediatr Cardiol 33:461-70. 2012
    ..of death in developed countries, with most SCDs involving the elderly, and structural heart disease evident at autopsy. Each year, however, thousands of sudden deaths involving individuals younger than 35 years of age remain ..
  86. ncbi Metastatic patterns at autopsy in patients with ovarian carcinoma
    Uwe Guth
    Department of Gynecology and Obstetrics, University Hospital Basel, Basel, Switzerland
    Cancer 110:1272-80. 2007
    Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences in factors that influence the course of disease...
  87. doi Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia aging study
    Lon White
    Pacific Health Research Institute and Kuakini Medical System, PHRI Bishop Street Tower, 700 Bishop Street, Suite 900, Honolulu, Hawaii 96813, USA
    J Alzheimers Dis 18:713-25. 2009
    ..In this autopsy panel, microvascular infarcts were identified as the sole or dominant lesion in 33...
  88. ncbi Café coronary syndrome-fatal choking on food: an autopsy approach
    Regula Wick
    Forensic Science SA and Department of Pathology, University of Adelaide, 21 Divett Place, 5000 Adelaide, Australia
    J Clin Forensic Med 13:135-8. 2006
    To examine the characteristic features of fatal food asphyxia and to develop an autopsy approach to such cases a retrospective study of autopsy files was undertaken at Forensic Science SA (Adelaide, Australia) over a 10 year period from ..
  89. pmc Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center
    Alberto Serrano-Pozo
    From the Massachusetts Alzheimer Disease Research Center, Massachusetts General Hospital AS P, MPF, BTH and Department of Biostatistics, Harvard School of Public Health JQ, Rab, Boston and Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst JQ, Massachusetts and National Alzheimer Coordinating Center and Department of Epidemiology, University of Washington, Seattle, Washington SEM
    J Neuropathol Exp Neurol 72:1182-92. 2013
    ..we selected a convenience sample of subjects from the National Alzheimer Coordinating Center 2005 to 2012 autopsy cohort (n = 2,083) with the last clinical evaluation within 2 years before autopsy and no other primary ..
  90. doi Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 118:1138-45. 2008
    The long-term safety of drug-eluting stents (DES) for acute myocardial infarction (AMI) remains uncertain. Using autopsy data, we evaluated the pathological responses of the stented segment in patients treated with DES for AMI and ..
  91. ncbi Gel-free analysis of the human brain proteome: application of liquid chromatography and mass spectrometry on biopsy and autopsy samples
    Debora Dumont
    Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium
    Proteomics 6:4967-77. 2006
    ..A biopsy and autopsy study sample derived from human brain was distributed among the participants for proteomic analysis...
  92. pmc AD brain pathology: vascular origins? Results from the HAAS autopsy study
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
    Neurobiol Aging 29:1587-90. 2008
    ..We examined this question in a fully characterized autopsy sample based on the Honolulu Asia Aging Study...
  93. ncbi Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization
    Christian Jackowski
    Centre of Forensic Imaging and Virtopsy, Institute of Forensic Medicine, University of Bern, IRM Bühlstrasse 20, CH 3012 Bern, Switzerland
    Eur Heart J 27:2459-67. 2006
    Postmortem magnetic resonance (MRI) imaging is currently evaluated as alternative to traditional autopsy and myocardial infarction plays a key role therein...
  94. pmc Utility of postmortem autopsy via whole-body imaging: initial observations comparing MDCT and 3.0 T MRI findings with autopsy findings
    Jang Gyu Cha
    Department of Radiology, Soonchunhyang University Bucheon Hospital, Gyunggi do 420 020, Korea
    Korean J Radiol 11:395-406. 2010
    We prospectively compared whole-body multidetector computed tomography (MDCT) and 3.0 T magnetic resonance (MR) images with autopsy findings.
  95. pmc Comparison of acute structural and histopathological changes in human autopsy eyes after endoscopic cyclophotocoagulation and trans-scleral cyclophotocoagulation
    Mina B Pantcheva
    UPMC Eye Center, Eye and Ear Institute, University of Pittsburg School of Medicine, Pittsburgh, PA, USA
    Br J Ophthalmol 91:248-52. 2007
    To study the histological effects of trans-scleral cyclophotocoagulation (TCP) and endoscopic cyclophotocoagulation (ECP) on the ciliary body and other structures collected at autopsy and to compare with untreated controls.
  96. doi Correlation between referral ultrasound with suspected foetal anomalies and autopsy examination in two prenatal diagnosis centres. Impact of the routine use of 3D/4D scan
    Olivier Picone
    Service de gynécologie obstétrique et médecine de la reproduction, Hopital Antoine Beclere, Assistance Publique Hopitaux de Paris AP HP, 157 rue de la Porte de Trivaux, Clamart Cedex, France
    Prenat Diagn 28:191-6. 2008
    To compare ultrasound diagnosis with autopsy findings in two tertiary referral foetal medicine centres, only one routinely using 3D and 4D ultrasound, and to compare results between the centres.
  97. pmc Capturing the context of maternal deaths from verbal autopsies: a reliability study of the maternal data extraction tool (M-DET)
    Ann L Montgomery
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada
    PLoS ONE 6:e14637. 2011
    ....
  98. doi Tuberculosis and tuberculosis/HIV/AIDS-associated mortality in Africa: the urgent need to expand and invest in routine and research autopsies
    Victor Mudenda
    University of Zambia and University College London Medical School, UNZA UCLMS, Research and Training Project, Lusaka, Zambia
    J Infect Dis 205:S340-6. 2012
    ..infectious causes of death in high-burden countries are based on clinical records, death certificates, and verbal autopsy studies. Causes of death ascertained through these methods are known to be grossly inaccurate...
  99. pmc Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol)
    Sudhin Thayyil
    Institute for Women s Health, University College London, London, UK
    BMC Pediatr 11:120. 2011
    Minimally invasive autopsy by post mortem magnetic resonance (MR) imaging has been suggested as an alternative for conventional autopsy in view of the declining consented autopsy rates...
  100. doi Epidemiological transition in a rural community of northern India: 18-year mortality surveillance using verbal autopsy
    Rajesh Kumar
    School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Epidemiol Community Health 66:890-3. 2012
    ..However, vital events registration systems are weak in developing countries. Therefore, verbal autopsy (VA) tools were incorporated in a community-based surveillance system to track causes of death.
  101. ncbi Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue
    D K Lahiri
    Laboratory of Molecular Neurogenetics, Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA
    Brain Res Brain Res Protoc 5:257-65. 2000
    ..we describe a rapid method for the isolation of good-quality DNA-binding proteins from cultured cell lines and autopsy tissue samples from the human brain...

Research Grants74

  1. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    ..It is also unlikely that human autopsy tissues are suitable for the direct determination of this small pool of highly reactive iron...
  2. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..Damage in the human brain has been confirmed via autopsy. Similar observations have been reported following both acute and chronic cyanide exposure...
  3. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..In the previous funding periods we leveraged several rare fetal/neonatal autopsy specimens to interrogate clues to pathogenesis...
  4. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..Braak and his colleagues reported that the youngest individuals in their large autopsy series showed pathological changes of PD only in the enteric nervous system (ENS), while PD pathology in the CNS ..
  5. Genomic adaptation to HIV infection of the CNS in opioid-abusers
    Rajnish S Dave; Fiscal Year: 2012
    ..To complement these studies, we will analyze the miRNA-mediated genomic adaptive response in brain autopsy tissues from HIV patients with or without opioid-abuse disorder...
  6. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ..Atherosclerosis primarily affects large and medium sized vessels with autopsy data demonstrating that the abdominal aorta offers a valuable early window for the study of atherosclerosis...
  7. White matter changes in HIV models
    Pamela E Knapp; Fiscal Year: 2011
    ..neurologic and/or psychiatric symptoms during their disease course, and pathology is seen in most brains at autopsy. There is also an increasing incidence of dementia in patients receiving HAART, attributed to emergence of ..
  8. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..Identification of EPCs as an operant process in brain AVMs can suggest lines of investigation to develop new treatment modalities. ..
  9. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..S. The mechanisms are unknown, but abnormalities in the serotonin system have been consistently found in autopsy studies...
  10. The Role of Connexin32 in the Pathogensis of CMTX
    STEVEN SIMON SCHERER; Fiscal Year: 2013
    ..MRI paints the picture of profound dysmyelination, but this has yet to be confirmed in an autopsy or biopsy...
  11. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..To address these issues, we will use prematurely delivered rabbit pups as an experimental animal and will also use autopsy materials from premature infants with and without brain hemorrhage.
  12. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..cerebrospinal fluid tapping, and/or expensive MRI or PET imaging, with definitive diagnosis deferred until brain autopsy. Our preliminary findings, based on new science concerning a novel molecular species, microRNAs (miR) and their "..
  13. microRNA analysis of neurons generated from patient-specific iPSCs
    Herbert M Lachman; Fiscal Year: 2013
    ..Investigators have had to resort to autopsy specimens and peripheral blood leukocytes to carry out such studies...
  14. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
    ..At autopsy, brains of DLBD patients have characteristic Lewy body aggregates throughout the cortex...
  15. Obesity related pancreatic fat worsens local injury via unsaturated fatty acids
    VIJAY PREM SINGH; Fiscal Year: 2013
    ..These studies could open a new therapeutic frontier for this devastating disease by targeting specific lipases(s) and by stratifying patients according to risk of severe AP based on findings of IPF on imaging studies. ..
  16. The role of indolamine2,3-dioxygenase in the host response/pathogenesis of Venezu
    Robert Seymour; Fiscal Year: 2013
    ..His other activities will include functioning as an attending of the autopsy service for 1 month per year and he will be involved in teaching medical and graduate students...
  17. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..g., 2-amyloid accumulation with or without dystrophic neuritis) in canines. Human autopsy studies and cross-sectional epidemiologic analyses have related ambient air pollution to neuropathology of brain ..
  18. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..In an exploratory analysis we test the same effects for or lithium. These results have implications for understanding the pathophysiology of depression and the mode of action of antidepressants and lithium treatment. ..
  19. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..of John Allman and Barbara Wold to investigate gene expression in laser micro-dissected cell populations in autopsy brains of well-phenotyped autistic individuals versus age and sex matched controls using a recently developed ..
  20. Mechanisms by which VZV IE proteins interact with cell antiviral proteins to prev
    MARIA ACENA NAGEL; Fiscal Year: 2013
    ..and viral titers will also be examined;(Aim 2) analyze latently-infected human ganglionic neurons obtained at autopsy for interactions of PML-NBs with VZV 61p and VZV 63p using techniques in Aim 1 and fluorescent in situ ..
  21. Cognitive Complaints and Decline and B-Amyloid Deposition in Non-Demented Elderly
    BETH ELLEN SNITZ; Fiscal Year: 2013
    ..with biological markers of AD, such as brain atrophy, reduced brain metabolism, and AD neuropathology on autopsy. These findings suggest that, for some, cognitive complaints likely represent a pre-symptomatic stage of AD which ..
  22. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..In up to 30% of cases of sudden cardiac death in the young (SCD), no specific diagnosis is found (autopsy negative)...
  23. Mechanisms of degeneration in the spinal cord and musculoskeletal system in SMA
    SANIYA FAYZULLINA; Fiscal Year: 2013
    ..This aim will be accomplished by examining, histologically and biochemically, spinal cord MN and skeletal muscle pathology in embryonic and neonatal SMA mice and in human SMA autopsy tissues.
  24. Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and Dementia
    GARY WILLIAM SMALL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Autopsy studies have shown that middle-aged adults with Down's syndrome (DS) exhibit the neuropathological hallmarks of Alzheimer's disease (AD): amyloid senile plaques (SPs) and tau ..
  25. Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
    David Alan Bennett; Fiscal Year: 2013
    ..studies of older men and women of comparable size, relevant life experiences, clinical data, and follow-up and autopsy rates, in which these analyses can be performed...
  26. DORSAL RAPHE NUCLEUS SEROTONIN NEURONS IN ALCOHOLISM
    Mark D Underwood; Fiscal Year: 2012
    ..Alcohol abuse/dependence will be diagnosed by psychological autopsy. Aim 1 seeks to define the capacity of DRN neurons to upregulate their function in alcoholics...
  27. Mitochondrial Dysfunction in Neurodegeneration of Aging
    Gary E Gibson; Fiscal Year: 2013
    ..Our results in human brains at autopsy in numerous age-related neurodegenerative diseases reveal decreased activity of the mitochondrial enzyme a- ..
  28. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..These results have implications for understanding the possibility to use trophic factors as ADT in MDD. ..
  29. The Ventral Medulla and the Sudden Infant Death Syndrome
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    ..syndrome (SIDS) is the sudden death of an infant that remains unexplained after a complete review of the history, autopsy, and death scene investigation;it is the leading cause of postneonatal infant mortality in the United States ..
  30. Prevention of VZV Reactivation
    Randall J Cohrs; Fiscal Year: 2013
    ..qualified to conduct our proposed studies since we have a continuous supply of fresh human ganglia obtained at autopsy, decades of expertise studying both the latent and lytic VZV transcriptome, and have developed ChIP assays and ..
  31. Genetic and Transcriptional Control of Spleen Development
    Licia Selleri; Fiscal Year: 2013
    ..blood filtering and its absence (as in congenital asplenia, an under-diagnosed disorder often recognized only at autopsy) results in a high risk for life-threatening bacterial infections in newborns and children...
  32. Thiamine Deficiency and Acquired Auditory Neuropathy
    M Charles Liberman; Fiscal Year: 2013
    ..Using animal models and human temporal bones obtained at autopsy, we will test the following hypotheses: 1) that the unique vulnerability of neonatal IHCs arises because of late-..
  33. Air Pollution and Cognitive Aging Among Older Women
    Jennifer Weuve; Fiscal Year: 2010
    ..In autopsy studies of dogs and humans, air pollution exposure is associated with Alzheimer-like changes in the brain...
  34. Multimodal Biomarkers in Frontotemporal Lobar Degeneration
    Corey T McMillan; Fiscal Year: 2013
    ..In recent years detailed neuropathological investigations at autopsy have demonstrated distinct sources of histopathological abnormalities in FTLD, including the presence of tau ..
  35. Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirgh (PASS) Network
    Kimberly A Dukes; Fiscal Year: 2013
    ..with ultrasonography, and neurotransmitter and synaptic maturation in the brainstem and cerebral cortex in autopsy studies of the fetus and infant...
  36. CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN AD
    Mony J de Leon; Fiscal Year: 2013
    ..HIP MRglc sampling accurately predicted the conversion of NL to MCI and to autopsy confirmed AD. However, MRglc measures lack pathological specificity for AD...
  37. Association of TFPI with antemortem dementia and postmortem micro brain infarcts
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    ..Of interest are the 404 individuals with and without dementia who later came to autopsy in which brain pathology was characterized...
  38. Cognitive Decline and Dementia: Life Experiences and the Brain Histone Epigenome
    David A Bennett; Fiscal Year: 2010
    ..studies of older men and women of comparable size, relevant life experiences, clinical data, and follow-up and autopsy rates, in which these analyses can be performed...
  39. Role of impaired cognitive states &risk factors in conversion to mixed dementias
    Lei Yu; Fiscal Year: 2013
    ..sclerosis, and mixed pathologies) relates to antemortem states in the subset of participants coming to autopsy. This aim could support proposed revisions of current neuropathological and clinical research diagnostic criteria ..
  40. Exploring the Genetics of Alzheimer's Disease in Humans and Drosophila
    Joshua M Shulman; Fiscal Year: 2013
    ..of the human genome for loci associated with a quantitative measure of AD neuropathology present in two large autopsy cohorts from community-based studies, the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP)..
  41. Early Detection of Pancreatic Cancer Using Ice COLD-PCR
    Grant Wu; Fiscal Year: 2012
    ..The method will be further validated in several tissues from well-characterized human pancreatic autopsy samples, including pancreas, blood and urine...
  42. The Role and Mechanisms of microRNAs in Diabetic Cornea
    Mehrnoosh Saghizadeh; Fiscal Year: 2013
    ..of actions, we will utilize adenovirus-driven microRNA-based gene therapy to treat human organ-cultured human autopsy diabetic corneas using functionally validated miRNAs...
  43. The Role of the Transient Outward Current in Genetically Elusive Sudden Death
    John R Giudicessi; Fiscal Year: 2013
    ..from heritable defects in cardiac ion channel function represent the most common identifiable causes underlying autopsy negative sudden death, including 35% of Sudden Unexplained Death Syndrome (SUDS) and 10% of Sudden Infant Death ..
  44. Reducing morbidity and mortality from acute febrile illness by improved diagnosis
    MEGAN ELIZABETH RELLER; Fiscal Year: 2012
    ..The actual sum and etiologic fractions are unknown, since few are diagnosed in life or classified by autopsy thereafter. Fever is often attributed erroneously to malaria in sub-Saharan Africa and to typhoid in South Asia...
  45. CAUSES OF AND ASSOCIATIONS WITH DEATH DURING LONG TERM HAART IN AFRICA
    Christopher J Hoffmann; Fiscal Year: 2013
    ..However, the optimum approach to allocating resources to maximize outcomes is currently unclear. Knowledge of risks for and causes of mortality can contribute to informing resource allocation aimed at improving health and survival. ..
  46. AD Gene Discovery: Exome Chip, New Endophenotypes &Functional Studies in CHARGE
    Sudha Seshadri; Fiscal Year: 2013
    ..and brain mRNA, miRNA, methylation data (n~8000 &750, respectively), hippocampal neuronal expression in autopsy brains and in Drosophila tau &[unreadable]-amyloid models...
  47. Very High Resolution Laboratory MicroCT Scanner
    D Rick Sumner; Fiscal Year: 2010
    ..The investigations use animal models and human autopsy material...
  48. Beta-Amyloid Immunization in a Canine Model of Aging
    Elizabeth Head; Fiscal Year: 2013
    ..Cognitive benefits were reported in this study and autopsy studies show a reduction in brain A[unreadable]...
  49. Epithelial Cell Apoptosis in Influenza A-Induced Lung Injury
    KATHRYN ANN RADIGAN; Fiscal Year: 2011
    ..This proposal seeks to determine the role of epithelial cell apoptosis in the development of influenza A-induced lung injury. These studies may identify novel targets for therapeutic drug development in influenza A infected patients. ..
  50. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2010
    ..in demyelination, as determined by visual-evoked cortical potentials (VECPs) and histologic examination at autopsy. In contrast, neither wild- type (wt) HSV infection alone nor HSV-IL-4, nor HSV-IFN-gamma virus (identical to HSV-..
  51. Stroke and aPL: Community-Based Clinicopathological Study
    STEVEN RICHARD LEVINE; Fiscal Year: 2012
    ..compare multiple to single aPL positivity, and to assess mechanisms of aPL associated cerebrovascular disease at autopsy. The proposed study will take advantage of ante-mortem biologic specimens, clinical and post-mortem data from two ..
  52. Molecular Basis of Iron Imbalance in sCJD Brain and CSF
    Neena Singh; Fiscal Year: 2013
    ..Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal prion disorder of humans that escapes detection until autopsy. The principal cause of neurotoxicity in this and other prion disorders is accumulation of PrP-scrapie (PrPSc), a ..
  53. Air Pollution, Systemic Inflammation, and Sub-Clinical Atherosclerosis in High-Al
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2010
    ..b>Autopsy and ultrasound studies have shown that atherogenesis begins early in life...
  54. Mechanisms of Multiple Sclerosis Tissue Pathology
    Claudia F Lucchinetti; Fiscal Year: 2012
    ..Our prior funded research focused on early biopsy and autopsy MS cases and revealed CDM occurs early;can be inflammatory;and meningeal inflammation is prominent...
  55. Identification of a Novel Gene for Parkinson Disease
    Han Xiang Deng; Fiscal Year: 2012
    ..Pathological analysis of the two autopsy samples revealed Parkinson pathology, including typical Lewy bodies...
  56. Essential Tremor: Gene expression profiling in cerebellar Purkinje cells
    Phyllis L Faust; Fiscal Year: 2012
    ..We will perform gene expression analyses by microarray screening on RNA isolated from PCs of ET versus control autopsy brains...
  57. Functional Dissection of the Sudden Cardiac Death Associated BAZ2B locus
    Dan E Arking; Fiscal Year: 2013
    ..Second, we will characterize the genetic variation in this region in 3,900 autopsy-identified SCD cases and >6,000 controls to: 1) identify the functional variant(s) underlying the identified ..
  58. ASDAMTS-13 and Inflammation
    TRUNG CHANH NGUYEN; Fiscal Year: 2012
    ....
  59. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2013
    ..The molecular mechanisms in SSA remain undefined, but are important to determine as autopsy studies have suggested that heart failure caused by amyloidosis may be vastly unrecognized and undiagnosed in the ..
  60. Role of Mucin in Lung Homeostasis and Pathophysiology
    Christopher M Evans; Fiscal Year: 2013
    ..b>Autopsy studies show that 98% of the airways of patients who die from fatal asthma have extensive mucus plugging...
  61. Longitudinal Changes in Pericardial Adiposity and Subclinical Atherosclerosis
    JOHN JEFFREY CARR; Fiscal Year: 2013
    ..are associated with culprit lesions of the acute coronary syndrome identified by intracoronary ultrasound or at autopsy. This proposal leverages the investment in CARDIA by adding new science related to PAT and its role in coronary ..
  62. Culture, Risk Factors and Suicide Attempt in Rural China
    Jie Zhang; Fiscal Year: 2013
    ..g. the value systems) in determining risk for suicide. Psychological autopsy (PA) studies with suicides are usually limited by their indirect evaluation and understanding of the suicides&..
  63. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..same clinical course as those in the blind trial? 4) Do transplant effects plateau and then decline? and 5) At autopsy, does the survival of dopamine cells and accompanying neurite outgrowth correlate with clinical and PET scan ..
  64. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2010
    ..At autopsy, brains of DLBD patients have characteristic Lewy body aggregates throughout the cortex...
  65. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2009
    ..Data from our autopsy-based study suggest that this standard clinical case definition is wrong 23% of the time (62)...
  66. DEVELOPMENT OF NOVEL BIOMARKERS FOR ALZHEIMER'S DISEASE
    James Moe; Fiscal Year: 2009
    ..Presently, definitive diagnosis of AD requires tissue biopsy or autopsy of the brain, which can occur only after the patient dies...
  67. Causes of early mortality in HIV-infected Africans on antiretroviral therapy
    ABRAHAM MOSIGISI SIIKA; Fiscal Year: 2012
    ..where very sick AMPATH- enrolled patients are admitted;(2) the MTRH Morgue which has cold storage facilities, an autopsy laboratory and 4 full-time pathologists;(3) the AMPATH Medical Record System (AMRS), a fully computerized system ..
  68. TYPE II COLLAGEN DENATURATION IN AGING AND OSTEOARTHRITI
    Anthony Poole; Fiscal Year: 2003
    ..We will examine aging human knee articular cartilages from autopsy and OA cartilages at arthroplasty, and those from the talus (ankle) (autopsy only)...
  69. MURINE MODEL OF HIV INFECTION OF HUMAN BRAIN
    Cristian Achim; Fiscal Year: 1999
    ..Recent studies have shown that all patients with HIV dementia have at autopsy neuropathologic changes consistent with HIV encephalitis...
  70. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 2000
    ..Moreover, BDV antigen and RNA have been detected in the hippocampus of autopsy brain samples from four patients who presented with major depression and memory loss...
  71. CLINICAL METABOLIC CORRELATION IN DEMENTIA BY PROTON NMR
    William Klunk; Fiscal Year: 1999
    ..Proton nuclear magnetic resonance spectroscopy (1/H MRS) will be used to analyze 6 brain areas obtained at autopsy from 75 Alzheimer's disease (AD), 25 controls, and 15 non-AD demented controls over 5 years...
  72. EARLY DEVELOPMENTAL GENES AND AUTISM
    Patricia Rodier; Fiscal Year: 2000
    ..To test the hypothesis that autism arises from injury to the closing neural tube, we examined an autistic autopsy case and found evidence of an early injury to the brain stem...
  73. MECHANISMS OF ACTIONS OF ALCOHOL AND OMEGA 3-FATTY ACIDS
    Raj Lakshman; Fiscal Year: 2004
    ..2. Both 2,6-ST-mRNA and GAPDH mRNA levels seemed to be intact in two autopsy liver samples from non-alcoholic controls. 3...
  74. SIV Encephalitis and Disease Progression
    Clayton Wiley; Fiscal Year: 2009
    ..In Specific Aim 3 we will measure synaptic and extracellular matrix damage in autopsy brain tissues and compare them to the temporal course of peripheral and central viral loads, DAA1106 binding...