Summary: Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis.

Top Publications

  1. ncbi Overcoming artifacts from metallic orthopedic implants at high-field-strength MR imaging and multi-detector CT
    Mi Jung Lee
    Department of Diagnostic Radiology and Research Institute of Radiological Science and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sincheon Dong Seodaemun Gu, Seoul 120 752, Republic of Korea
    Radiographics 27:791-803. 2007
  2. pmc Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e27310. 2011
  3. ncbi Removing electroencephalographic artifacts by blind source separation
    T P Jung
    Howard Hughes Medical Institute, Salk Institute, San Diego, California, USA
    Psychophysiology 37:163-78. 2000
  4. ncbi Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR
    G H Glover
    Department of Radiology, Stanford University School of Medicine, Center for Advanced MR Technology at Stanford, Stanford, California, USA
    Magn Reson Med 44:162-7. 2000
  5. ncbi Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo
    T G Reese
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Magn Reson Med 49:177-82. 2003
  6. ncbi Image distortion correction in fMRI: A quantitative evaluation
    Chloe Hutton
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WCIN 3BG, United Kingdom
    Neuroimage 16:217-40. 2002
  7. pmc Image reconstruction in circular cone-beam computed tomography by constrained, total-variation minimization
    Emil Y Sidky
    Department of Radiology MC 2026, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Phys Med Biol 53:4777-807. 2008
  8. pmc PCR-induced sequence artifacts and bias: insights from comparison of two 16S rRNA clone libraries constructed from the same sample
    Silvia G Acinas
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Environ Microbiol 71:8966-9. 2005
  9. ncbi RESTORE: robust estimation of tensors by outlier rejection
    Lin Ching Chang
    Section on Tissue Biophysics and Biomimetics, Laboratory of Integrative Medicine and Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Med 53:1088-95. 2005
  10. ncbi Suppression of interference and artifacts by the Signal Space Separation Method
    Samu Taulu
    Elekta Neuromag Oy, Helsinki, Finland
    Brain Topogr 16:269-75. 2004

Detail Information

Publications380 found, 100 shown here

  1. ncbi Overcoming artifacts from metallic orthopedic implants at high-field-strength MR imaging and multi-detector CT
    Mi Jung Lee
    Department of Diagnostic Radiology and Research Institute of Radiological Science and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sincheon Dong Seodaemun Gu, Seoul 120 752, Republic of Korea
    Radiographics 27:791-803. 2007
    At magnetic resonance (MR) imaging and multidetector computed tomography (CT), artifacts arising from metallic orthopedic hardware are an obstacle to obtaining optimal images...
  2. pmc Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e27310. 2011
  3. ncbi Removing electroencephalographic artifacts by blind source separation
    T P Jung
    Howard Hughes Medical Institute, Salk Institute, San Diego, California, USA
    Psychophysiology 37:163-78. 2000
    ..Many methods have been proposed to remove artifacts from EEG recordings, especially those arising from eye movements and blinks...
  4. ncbi Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR
    G H Glover
    Department of Radiology, Stanford University School of Medicine, Center for Advanced MR Technology at Stanford, Stanford, California, USA
    Magn Reson Med 44:162-7. 2000
    ..The method is found to perform well for both respiration- and cardiac-induced noise without imposing spatial filtering on the correction. Magn Reson Med 44:162-167, 2000...
  5. ncbi Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo
    T G Reese
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Magn Reson Med 49:177-82. 2003
    Image distortion due to field gradient eddy currents can create image artifacts in diffusion-weighted MR images...
  6. ncbi Image distortion correction in fMRI: A quantitative evaluation
    Chloe Hutton
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WCIN 3BG, United Kingdom
    Neuroimage 16:217-40. 2002
    ..but requires postprocessing to improve the robustness of the acquired field map and reduce any secondary artifacts. Furthermore, the distribution of the internal magnetic field throughout the head is position dependent ..
  7. pmc Image reconstruction in circular cone-beam computed tomography by constrained, total-variation minimization
    Emil Y Sidky
    Department of Radiology MC 2026, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Phys Med Biol 53:4777-807. 2008
    ..It appears to be robust against cone-beam artifacts, and may be particularly useful when the angular range is limited or when the angular sampling rate is low...
  8. pmc PCR-induced sequence artifacts and bias: insights from comparison of two 16S rRNA clone libraries constructed from the same sample
    Silvia G Acinas
    Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Environ Microbiol 71:8966-9. 2005
    The contribution of PCR artifacts to 16S rRNA gene sequence diversity from a complex bacterioplankton sample was estimated...
  9. ncbi RESTORE: robust estimation of tensors by outlier rejection
    Lin Ching Chang
    Section on Tissue Biophysics and Biomimetics, Laboratory of Integrative Medicine and Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Magn Reson Med 53:1088-95. 2005 diffusion weighted imaging (DWI) is influenced by both thermal noise and spatially and temporally varying artifacts such as subject motion and cardiac pulsation...
  10. ncbi Suppression of interference and artifacts by the Signal Space Separation Method
    Samu Taulu
    Elekta Neuromag Oy, Helsinki, Finland
    Brain Topogr 16:269-75. 2004
    ..When used with properly designed sensor array, SSS does not affect the morphology or the signal-to-noise ratio of the interesting signals...
  11. ncbi Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI
    Rasmus M Birn
    Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, 10 Center Dr, Bldg 10, Rm 1D80 Bethesda, MD 20892 1148, USA
    Neuroimage 31:1536-48. 2006
    ..Regressing out global signal changes or cueing the subject to breathe at a constant rate and depth resulted in an improved spatial overlap between deactivations and resting-state correlations among areas that showed deactivation...
  12. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  13. ncbi Removal of eye activity artifacts from visual event-related potentials in normal and clinical subjects
    T P Jung
    University of California, San Diego, La Jolla, CA 92093, USA
    Clin Neurophysiol 111:1745-58. 2000
    ..Often, all epochs contaminated by large eye artifacts are rejected as unusable, though this may prove unacceptable when blinks and eye movements occur frequently.
  14. ncbi Distortion correction and robust tensor estimation for MR diffusion imaging
    J F Mangin
    Service Hospitalier Frederic Joliot, CEA, 91401 Orsay, France
    Med Image Anal 6:191-8. 2002
    ..Several experiments prove that the whole procedure highly improves the quality of the final diffusion maps...
  15. ncbi Immunolabeling artifacts and the need for live-cell imaging
    Ulrike Schnell
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nat Methods 9:152-8. 2012
  16. pmc Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCR'
    Janelle R Thompson
    Massachusetts Institute of Technology, Department of Civil and Environmental Engineering, Cambridge, MA 02139, USA
    Nucleic Acids Res 30:2083-8. 2002
    Although it has been recognized that PCR amplification of mixed templates may generate sequence artifacts, the mechanisms of their formation, frequency and potential elimination have not been fully elucidated...
  17. pmc Electromyogenic artifacts and electroencephalographic inferences
    Alexander J Shackman
    Laboratory for Affective Neuroscience and Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, W J Brogden Hall, 1202 West Johnson Street, Madison, WI 53706, USA
    Brain Topogr 22:7-12. 2009
    ..We conclude by describing emerging methodological trends in this area that are likely to have substantial benefits for basic and applied EEG research...
  18. ncbi Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT
    Medhat M Osman
    Department of Internal Medicine, Division of Nuclear Medicine, Saint Louis University, 3635 Vista at Grand FOT2, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:603-6. 2003
    ..attenuation correction (CTAC) instead of germanium-68 attenuation correction (Ge AC) might be expected to cause artifacts on reconstructed emission images if differences in respiratory status exist between the two methods of ..
  19. ncbi Head injury or head motion? Assessment and quantification of motion artifacts in diffusion tensor imaging studies
    Josef Ling
    The MIND Research Network, Albuquerque, New Mexico 87106, USA
    Hum Brain Mapp 33:50-62. 2012
    ..However, the removal of images with gross artifacts did not fundamentally change the relationship between motion and DTI scalar values...
  20. ncbi Reducing sequence artifacts in amplicon-based massively parallel sequencing of formalin-fixed paraffin-embedded DNA by enzymatic depletion of uracil-containing templates
    Hongdo Do
    Molecular Pathology Research and Development Laboratory, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Clin Chem 59:1376-83. 2013
    ..We investigated whether sequence artifacts were problematic in amplicon-based massively parallel sequencing and what effect UDG pretreatment had on ..
  21. ncbi Evaluation of artifacts and distortions of titanium applicators on 3.0-Tesla MRI: feasibility of titanium applicators in MRI-guided brachytherapy for gynecological cancer
    Yusung Kim
    Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA
    Int J Radiat Oncol Biol Phys 80:947-55. 2011
    The aim of this study was to characterize the levels of artifacts and distortions of titanium applicators on 3.0-Tesla magnetic resonance imaging (MRI).
  22. ncbi Detection of sonographic B-lines in patients with normal lung or radiographic alveolar consolidation
    Giovanni Volpicelli
    Department of Emergency Medicine, San Luigi Gonzaga Hospital, Torino, Italy
    Med Sci Monit 14:CR122-8. 2008
    Diffuse comet-tail B-line artifacts in lung ultrasound are a sign of alveolar-interstitial syndrome, but isolated transthoracic scans positive for B-lines (multiple B lines or B+) could be detected in other conditions...
  23. ncbi Physiological noise in oxygenation-sensitive magnetic resonance imaging
    G Kruger
    Lucas MRS Center, Department of Radiology, Stanford University, Palo Alto, California, USA
    Magn Reson Med 46:631-7. 2001
    ..The SNR in oxygenation-sensitive MRI is predicted to saturate at higher fields, suggesting that noise measurements of the resting brain at 3.0 T and higher may provide a sensitive probe of functional information...
  24. pmc ChIP on Chip: surprising results are often artifacts
    Torsten Waldminghaus
    Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital and University of Oslo, 0310 Oslo, Norway
    BMC Genomics 11:414. 2010
    ..The method of chromatin immunoprecipitation combined with microarrays (ChIP-Chip) is a powerful tool for genome-wide analysis of protein binding. However, a high background signal is a common phenomenon...
  25. ncbi Four-dimensional (4D) PET/CT imaging of the thorax
    S A Nehmeh
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 31:3179-86. 2004
    ..We have shown that 4D PET/CT is clinically a feasible method, to correct for respiratory motion artifacts in PET/CT imaging of the thorax...
  26. pmc Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
    C Li
    Departments of Statistics and Human Genetics, University of California, Los Angeles, CA 90095
    Proc Natl Acad Sci U S A 98:31-6. 2001
    ..We also present model-based methods for identifying and handling cross-hybridizing probes and contaminating array regions. Applications of these results will be presented elsewhere...
  27. ncbi Statistical control of artifacts in dense array EEG/MEG studies
    M Junghofer
    Department of Psychology, University of Konstanz, Germany
    Psychophysiology 37:523-32. 2000
    ..We propose a procedure for statistical correction of artifacts in dense array studies (SCADS), which (1) detects individual channel artifacts using the recording reference, (2)..
  28. pmc DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA
    M Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany
    Nucleic Acids Res 29:4793-9. 2001
    ..1% even under the unlikely scenario where each amplification starts from a single template molecule...
  29. pmc Identification and resolution of artifacts in the interpretation of imprinted gene expression
    Charlotte Proudhon
    Institut Curie in Paris, France
    Brief Funct Genomics 9:374-84. 2010
    ..A very large number of technical and biological artifacts can also lead to the erroneous evidence of imprinted gene expression...
  30. ncbi Patching cardiac and head motion artefacts in diffusion-weighted images
    Marcel P Zwiers
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, HB Nijmegen, The Netherlands
    Neuroimage 53:565-75. 2010
    ..The method is not limited to diffusion tensor imaging but also yields objective artefact reflecting weights that can be used to inform subsequent processing or estimation of higher-order diffusion models...
  31. pmc Suppression of artifacts and barcode bias in high-throughput transcriptome analyses utilizing template switching
    Dave T P Tang
    Omics Science Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho, Yokohama, Kanagawa 230 0045, Japan
    Nucleic Acids Res 41:e44. 2013
    ..Here, we report TS artifacts that form owing to a process called strand invasion...
  32. ncbi Automatic removal of eye-movement and blink artifacts from EEG signals
    Jun Feng Gao
    Research Institute of Biomedical Engineering, Xi an Jiaotong University, China
    Brain Topogr 23:105-14. 2010
    Frequent occurrence of electrooculography (EOG) artifacts leads to serious problems in interpreting and analyzing the electroencephalogram (EEG)...
  33. ncbi A fully automated correction method of EOG artifacts in EEG recordings
    A Schlogl
    Institute of Human Computer Interfaces, Graz University of Technology, Krenngasse 37 IV, A 8010 Graz, Austria
    Clin Neurophysiol 118:98-104. 2007
    A fully automated method for reducing EOG artifacts is presented and validated.
  34. ncbi Measuring rDNA diversity in eukaryotic microbial systems: how intragenomic variation, pseudogenes, and PCR artifacts confound biodiversity estimates
    Daniel J Thornhill
    Department of Biological Sciences, Auburn University, 101 Rouse Life Sciences Building, Auburn, Alabama 36849, USA
    Mol Ecol 16:5326-40. 2007
    ..These considerations must be taken into account when interpreting sequence data generated by bacterial cloning of multicopy genes such as rDNA...
  35. pmc Particle-induced artifacts in the MTT and LDH viability assays
    Amara L Holder
    Division of Environmental Health Sciences, University of California, Berkeley, CA 94720, USA
    Chem Res Toxicol 25:1885-92. 2012
    ..We conclude that valid particle toxicity assessments can only be assured after first performing controls to verify that the particles under investigation do not interfere with a specific assay at the expected concentrations...
  36. ncbi How to detect and reduce movement artifacts in near-infrared imaging using moving standard deviation and spline interpolation
    F Scholkmann
    Biomedical Optics Research Laboratory BORL, Clinic of Neonatology, University Hospital Zurich, 8091 Zurich, Switzerland
    Physiol Meas 31:649-62. 2010
    ..Since the technique is very sensitive, the movement of a subject can cause movement artifacts (MAs), which affect the signal quality and results to a high degree...
  37. ncbi Bootstrap quantification of cardiac pulsation artifact in DTI
    SungWon Chung
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, CA, USA
    Neuroimage 49:631-40. 2010
    ..We have demonstrated that cardiac gating, especially of partial Fourier acquisitions, can reduce the uncertainties of DTI derived parameters in a time-efficient manner...
  38. ncbi Effect of respiratory gating on quantifying PET images of lung cancer
    Sadek A Nehmeh
    Department of Medical Physics, Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 43:876-81. 2002
    ..We have developed a new technique to gate lung 18F-FDG PET images in synchronization with the respiratory motion to reduce smearing due to breathing and improve quantitation of 18F-FDG uptake in lung lesions...
  39. pmc Activity inference for Ambient Intelligence through handling artifacts in a healthcare environment
    Francisco E Martínez-Pérez
    Facultad de Ingenieria, Universidad Autonoma de Baja California, Km 103 Carretera Tijuana Ensenada, Ensenada, B C 022860, Mexico
    Sensors (Basel) 12:1072-99. 2012
    ..We discuss how the use of RBs might positively impact the problems faced by designers and developers for recovering information in an easier manner and thus they can develop tools focused on the user...
  40. pmc fMRI in the presence of task-correlated breathing variations
    Rasmus M Birn
    Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, 10 Center Dr, Bldg 10, Rm 1D80, Bethesda, MD 20892 1148, USA
    Neuroimage 47:1092-104. 2009
  41. ncbi Identification and resolution of artifacts in bisulfite sequencing
    Peter M Warnecke
    Sydney Cancer Centre, Kanematsu Laboratories, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales 2050, Australia
    Methods 27:101-7. 2002
    ..In this article, we address the more commonly encountered experimental artifacts associated with bisulfite sequencing, and provide methods for the detection and elimination of these artifacts...
  42. ncbi Investigations on the efficiency of cardiac-gated methods for the acquisition of diffusion-weighted images
    Rita G Nunes
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, UK
    J Magn Reson 177:102-10. 2005
    ..The merits and disadvantages of this optimized approach are investigated here, in comparison to a more standard gating method and to the non-gated approach...
  43. ncbi Correcting eddy current and motion effects by affine whole-brain registrations: evaluation of three-dimensional distortions and comparison with slicewise correction
    Siawoosh Mohammadi
    Department of Neurology, University of Munster, Albert Schweitzer Straße 33, D 48129 Munster, Germany
    Magn Reson Med 64:1047-56. 2010
  44. ncbi Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers
    Robert Landsiedel
    Department of Product Safety, BASF SE, 67056 Ludwigshafen, Germany
    Mutat Res 681:241-58. 2009
    ..This review should help to improve standard genotoxicity testing as well as investigations on the underlying mechanism and the interpretation of genotoxicity data on nanomaterials...
  45. ncbi Artifacts in CT: recognition and avoidance
    Julia F Barrett
    Imaging Performance Assessment of CT Scanners, St George s Hospital, Blackshaw Rd, London SW17 0QT, England
    Radiographics 24:1679-91. 2004
    b>Artifacts can seriously degrade the quality of computed tomographic (CT) images, sometimes to the point of making them diagnostically unusable...
  46. ncbi 3.0 T vs. 1.5 T MR angiography: in vitro comparison of intravascular stent artifacts
    Alexander Wall
    Department of Clinical Radiology, University of Munster, Munster, Germany
    J Magn Reson Imaging 22:772-9. 2005
    ..To evaluate the signal characteristics of different iliac artery stents in MR angiography (MRA) at 3 T in comparison with 1.5 T...
  47. ncbi Optimization of an independent component analysis approach for artifact identification and removal in magnetoencephalographic signals
    Giulia Barbati
    Department of Neuroscience, AFaR Center of Medical Statistics and Information Technology, Fatebenefratelli Hospital, Isola Tiberina, Lungotevere degli Anguillara 12, 00153 Rome, Italy
    Clin Neurophysiol 115:1220-32. 2004
  48. ncbi Issues of spectral quality in clinical 1H-magnetic resonance spectroscopy and a gallery of artifacts
    Roland Kreis
    Department of Clinical Research, Unit for MR Spectroscopy and Methodology, University Berne, Switzerland
    NMR Biomed 17:361-81. 2004
    ..Furthermore, artifacts are not at all conspicuous in MRS and can easily be taken for true, interpretable features...
  49. ncbi Addressing a systematic vibration artifact in diffusion-weighted MRI
    Daniel Gallichan
    Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Hum Brain Mapp 31:193-202. 2010
    ..We also demonstrate that the artifact may be avoided by acquiring full k-space data, and that subsequent increases in TE can be avoided by employing parallel acceleration...
  50. ncbi Non-white noise in fMRI: does modelling have an impact?
    Torben E Lund
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Neuroimage 29:54-66. 2006
    ..In addition, we also compare the performance of the NVR method to the whitening approach implemented in SPM2...
  51. pmc Harshlight: a "corrective make-up" program for microarray chips
    Mayte Suárez-Fariñas
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Ave, Box 212, New York, NY 10021, USA
    BMC Bioinformatics 6:294. 2005
    ..Microarray scans do show similar artifacts, which might affect subsequent analysis...
  52. pmc Algorithm-driven artifacts in median Polish summarization of microarray data
    Federico M Giorgi
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476 Golm, Germany
    BMC Bioinformatics 11:553. 2010
  53. ncbi Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts
    G H Glover
    Department of Radiology, Center for Advanced MR Technology, Stanford University School of Medicine, Stanford, California 94305 5488, USA
    Magn Reson Med 46:515-22. 2001 combined in several ways to simultaneously achieve increased signal-to-noise ratio (SNR) and reduced dropout artifacts. Activation experiments employing an olfaction task demonstrate significantly increased activation volumes due ..
  54. pmc A soft-threshold filtering approach for reconstruction from a limited number of projections
    Hengyong Yu
    Department of Radiology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Phys Med Biol 55:3905-16. 2010
    ..These two methods are evaluated in numerical simulation. The results demonstrate the merits of the proposed techniques...
  55. ncbi Properties of the ballistocardiogram artefact as revealed by EEG recordings at 1.5, 3 and 7 T static magnetic field strength
    Stefan Debener
    Medical Research Council Institute of Hearing Research, Royal South Hants Hospital, Southampton, SO14 OYG, United Kingdom
    Int J Psychophysiol 67:189-99. 2008
    ..This is summarized in a preliminary BCG model that may help to explain recent inconsistencies regarding the usefulness of ICA for BCG removal. It may also guide the future development of more advanced BCG removal procedures...
  56. ncbi Imaging artifacts at 3.0T
    Matt A Bernstein
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 24:735-46. 2006
    ..0T, such as increased SNR, there can be drawbacks, including increased levels of imaging artifacts. Although every imaging artifact observed at 3.0T can also be present at 1...
  57. ncbi Artifacts in 3-T MRI: physical background and reduction strategies
    Olaf Dietrich
    Department of Clinical Radiology Grosshadern, Ludwig Maximilian University of Munich, Marchioninistr 15, 81377 Munich, Germany
    Eur J Radiol 65:29-35. 2008
    ..for 3 T, radiologists and technicians working at these systems are relatively often confronted with image artifacts related to 3-T MRI...
  58. ncbi Sharp edge artifacts and spurious coupling in EEG frequency comodulation measures
    Mark A Kramer
    Department of Mathematics and Statistics and Center for BioDynamics, Boston University, Boston, MA 02215, USA
    J Neurosci Methods 170:352-7. 2008
    ..In this short communication, we describe how abrupt increases or decreases in voltage data may produce spurious coupling in these measures and suggest techniques to detect these effects...
  59. pmc Removal of movement artifact from high-density EEG recorded during walking and running
    Joseph T Gwin
    Human Neuromechanics Laboratory, School of Kinesiology University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 103:3526-34. 2010
    ..These findings show that high-density EEG can be used to study brain dynamics during whole body movements and that mechanical artifact from rhythmic gait events may be minimized using a template regression procedure...
  60. ncbi Motion in cardiovascular MR imaging
    Andrew D Scott
    Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital, London, England
    Radiology 250:331-51. 2009
    ..the type and extent of the motion of the heart due to the cardiac and respiratory cycles, which create image artifacts. Methods of eliminating or reducing the problems caused by the cardiac cycle are discussed, including ..
  61. ncbi Removal of FMRI environment artifacts from EEG data using optimal basis sets
    R K Niazy
    University of Oxford, Centre for Functional MRI of the Brain FMRIB, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Neuroimage 28:720-37. 2005
    ..However, EEG data collected in such experiments suffer from two kinds of artifact. First, gradient artifacts are caused by the switching of magnetic gradients during FMRI...
  62. pmc Flow measurement by cardiovascular magnetic resonance: a multi-centre multi-vendor study of background phase offset errors that can compromise the accuracy of derived regurgitant or shunt flow measurements
    Peter D Gatehouse
    CMR Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 12:5. 2010
    ..We studied the severity of uncorrected velocity offset errors across sites and CMR systems...
  63. pmc Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices
    Joseph Ho
    New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA
    Ophthalmology 116:1960-70. 2009
    To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier ..
  64. ncbi Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up
    Jean Luc Ravanat
    Laboratoire Lesions des Acides Nucleiques, DRFMC SCIB UMR 5046 CEA Grenoble, 17 Avenue des Martyrs, F 38054 Grenoble Cedex 9, France
    Carcinogenesis 23:1911-8. 2002
    ..Using the best-studied protocol, the steady-state cellular background level of 8-oxodGuo, in a lymphocyte cell line, was determined to be approximately 0.5 lesions/10(6) DNA nucleosides...
  65. ncbi Statistical artifacts in diffusion tensor MRI (DT-MRI) caused by background noise
    P J Basser
    Section on Tissue Biophysics and Biomimetics, Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892 5772, USA
    Magn Reson Med 44:41-50. 2000
    This work helps elucidate how background noise introduces statistical artifacts in the distribution of the sorted eigenvalues and eigenvectors in diffusion tensor MRI (DT-MRI) data...
  66. pmc Cardiovascular magnetic resonance physics for clinicians: Part II
    John D Biglands
    University of Leeds and Department of Medical Physics and Engineering, Leeds Teaching Hospitals NHS Trust, 1st Floor, Bexley Wing, St James s University Hospital, Leeds, LS9 7TF, UK
    J Cardiovasc Magn Reson 14:66. 2012
    ..Choice of velocity encoding range and key pitfalls in the use of this technique are discussed...
  67. ncbi Fully automated reduction of ocular artifacts in high-dimensional neural data
    John W Kelly
    Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    IEEE Trans Biomed Eng 58:598-606. 2011
    The reduction of artifacts in neural data is a key element in improving analysis of brain recordings and the development of effective brain-computer interfaces...
  68. pmc A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking
    Laura C Zanetti-Domingues
    Central Laser Facility, Science and Technology Facilities Council, Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Oxford, Didcot, United Kingdom
    PLoS ONE 7:e45655. 2012
    ..Non-specific binding of probes to glass substrates, in particular, can produce experimental artifacts due to spurious molecules on glass, which can be particularly deleterious in live-cell tracking experiments...
  69. ncbi Analysis and generalized correction of the effect of spatial gradient field distortions in diffusion-weighted imaging
    R Bammer
    Lucas MRS I Center, Department of Radiology, Stanford University, Stanford, California 94305, USA
    Magn Reson Med 50:560-9. 2003
    Nonuniformities of magnetic field gradients can cause serious artifacts in diffusion imaging...
  70. ncbi Automated artifact detection and removal for improved tensor estimation in motion-corrupted DTI data sets using the combination of local binary patterns and 2D partial least squares
    Zhenyu Zhou
    MRI Unit, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Magn Reson Imaging 29:230-42. 2011 diffusion-weighted images (DWIs) is influenced both by thermal noise and by spatially and temporally varying artifacts, such as rigid-body motion and cardiac pulsation...
  71. ncbi Reduced aliasing artifacts using variable-density k-space sampling trajectories
    C M Tsai
    Department of Electrical Engineering, Stanford University, California, USA
    Magn Reson Med 43:452-8. 2000
    A variable-density k-space sampling method is proposed to reduce aliasing artifacts in MR images...
  72. ncbi Interpolated average CT for attenuation correction in PET--a simulation study
    Greta S P Mok
    Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, China
    IEEE Trans Biomed Eng 60:1927-34. 2013
    ..Significant artifacts were observed in the reconstructed images using HCTs for AC...
  73. ncbi Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T
    R Deichmann
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuroimage 21:757-67. 2004
    ..It is shown both theoretically and experimentally that these problems can be avoided by using spin tagging and fat saturation...
  74. pmc Confidence-based somatic mutation evaluation and prioritization
    Martin Löwer
    TRON Translational Oncology at Johannes Gutenberg University of Mainz Medicine, Mainz, Germany
    PLoS Comput Biol 8:e1002714. 2012
    ..Using the HiSeq 2000, single end 50 nt reads from replicates generate the highest confidence somatic mutation call set...
  75. ncbi Reducing abdominal CT radiation dose with adaptive statistical iterative reconstruction technique
    Priyanka Prakash
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Invest Radiol 45:202-10. 2010
    ..To assess radiation dose reduction for abdominal computed tomography (CT) examinations with adaptive statistical iterative reconstruction (ASIR) technique...
  76. ncbi Comparison of dual-source CT coronary angiography and conventional coronary angiography for detecting coronary artery disease
    Yi Xu
    Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China
    Int J Cardiovasc Imaging 26:75-81. 2010
    ..076). The diagnostic performance of DSCT-CCTA is generally as accurate as that of CAG. Thus, DSCT-CCTA is a reliable non-invasive method for detecting coronary artery stenosis...
  77. ncbi Automatic correction of ocular artifacts in the EEG: a comparison of regression-based and component-based methods
    Garrick L Wallstrom
    Center for Biomedical Informatics, University of Pittsburgh, Forbes Tower Suite 8084, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Int J Psychophysiol 53:105-19. 2004
    A variety of procedures have been proposed to correct ocular artifacts in the electroencephalogram (EEG), including methods based on regression, principal components analysis (PCA) and independent component analysis (ICA)...
  78. ncbi Retrospective gating vs. prospective triggering for noninvasive coronary angiography: Assessment of image quality and radiation dose using a 256-slice CT scanner with 270 ms gantry rotation
    Wei Yip Law
    Department of Radiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan, ROC
    Acad Radiol 18:31-9. 2011
  79. ncbi Multidistance probe arrangement to eliminate artifacts in functional near-infrared spectroscopy
    Toru Yamada
    National Institute of Advanced Industrial Science and Technology, Neuroscience Research Institute, 1 1 1 Umezono Central 2, Tsukuba, Ibaraki 305 8568, Japan
    J Biomed Opt 14:064034. 2009
    ..practical fNIRS measurements, a subject's physical or systemic physiological activities often cause undesirable artifacts. Such activities can be evoked even by task execution...
  80. pmc Arrhythmia ECG noise reduction by ensemble empirical mode decomposition
    Kang Ming Chang
    Department of Photonics and Communication Engineering, Asia University, Wufeng, Taichung County, 500, Lioufeng Rd, Wufeng, Taichung County, 41354, Taiwan
    Sensors (Basel) 10:6063-80. 2010
    A novel noise filtering algorithm based on ensemble empirical mode decomposition (EEMD) is proposed to remove artifacts in electrocardiogram (ECG) traces...
  81. ncbi Evaluation of two iterative techniques for reducing metal artifacts in computed tomography
    F Edward Boas
    Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr, Room H 1307, Stanford, CA 94305, USA
    Radiology 259:894-902. 2011
    To evaluate two methods for reducing metal artifacts in computed tomography (CT)--the metal deletion technique (MDT) and the selective algebraic reconstruction technique (SART)--and compare these methods with filtered back projection (..
  82. ncbi Analysis and visualization of single-trial event-related potentials
    T P Jung
    Institute for Neural Computation, University of California San Diego, La Jolla, California 92093 0523, USA
    Hum Brain Mapp 14:166-85. 2001 22 neurological patients whose EEG records were heavily contaminated with blink and other eye-movement artifacts. Results show that ICA can separate artifactual, stimulus-locked, response-locked, and non-event-related ..
  83. pmc Single-cell copy number variation detection
    Jiqiu Cheng
    Department of Electrical Engineering, ESAT SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven 3001, Belgium
    Genome Biol 12:R80. 2011
    ..However, such detection is challenging because of the genome artifacts and the DNA amplification process inherent to the single cell approach...
  84. ncbi ICA-based muscle artefact correction of EEG data: what is muscle and what is brain? Comment on McMenamin et al
    Sebastian Olbrich
    Department of Psychiatry and Psychotherapy of the University Clinic of Leipzig, Leipzig, Germany
    Neuroimage 54:1-3; discussion 4-9. 2011
    ..ICA-based artefact correction already provides a powerful tool for muscle artefact rejection. More research is needed for determining reliable criteria to delineate myogenic from neurogenic components...
  85. ncbi Reducing chimera formation during PCR amplification to ensure accurate genotyping
    R P Smyth
    Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, Victoria, Australia
    Gene 469:45-51. 2010
    ..This procedure will facilitate the generation of data sets that more accurately reflect the underlying population diversity rather than artifacts introduced by the process itself.
  86. ncbi The role of physiological noise in resting-state functional connectivity
    Rasmus M Birn
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Neuroimage 62:864-70. 2012
  87. pmc Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
    Alinda Nagy
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H 1113 Budapest, Hungary
    BMC Bioinformatics 9:353. 2008
  88. ncbi Suppression of metal artifacts in CT using a reconstruction procedure that combines MAP and projection completion
    Catherine Lemmens
    Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 28:250-60. 2009
    Metal implants such as hip prostheses and dental fillings produce streak and star artifacts in the reconstructed computed tomography (CT) images. Due to these artifacts, the CT image may not be diagnostically usable...
  89. ncbi Comparison of principal and independent component analysis in removing extracerebral interference from near-infrared spectroscopy signals
    Jaakko Virtanen
    Helsinki University of Technology, Department of Biomedical Engineering and Computational Science, P O Box 3310, FI 02015 TKK, Helsinki, Finland
    J Biomed Opt 14:054032. 2009
    ..Performance differences between PCA and ICA could be attributed primarily to different criteria for identifying the surface effect...
  90. ncbi Validation of ICA as a tool to remove eye movement artifacts from EEG/ERP
    Maarten Mennes
    Department of Woman and Child, KU Leuven, Leuven, Belgium
    Psychophysiology 47:1142-50. 2010
    Eye movement artifacts in electroencephalogram (EEG) recordings can greatly distort grand mean event-related potential (ERP) waveforms. Different techniques have been suggested to remove these artifacts prior to ERP analysis...
  91. pmc Physiological noise and signal-to-noise ratio in fMRI with multi-channel array coils
    Christina Triantafyllou
    Athinoula A Martinos Imaging Center at McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroimage 55:597-606. 2011
    ..At higher acceleration factors, image SNR is reduced and the time-series becomes increasingly thermal noise dominant. However, the tSNR reduction is smaller than the reduction in image SNR due to the presence of physiological noise...
  92. ncbi In vitro evaluation of intravascular stent artifacts in three-dimensional MR angiography
    D Maintz
    Department of Diagnostic Radiology, University of Cologne, School of Medicine, Cologne, Germany
    Invest Radiol 36:218-24. 2001
    ..To evaluate the intraluminal signal characteristics of various stents and stent-grafts in contrast-enhanced three-dimensional MR angiography (3D MRA) in vitro...
  93. ncbi Semi-automatic identification of independent components representing EEG artifact
    Filipa Campos Viola
    MRC Institute of Hearing Research, Southampton, UK
    Clin Neurophysiol 120:868-77. 2009
    ..component analysis (ICA) can disentangle multi-channel electroencephalogram (EEG) signals into a number of artifacts and brain-related signals...
  94. ncbi Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences
    Petra Mürtz
    Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Radiology 224:258-64. 2002
    ..Pulse triggering to the diastolic heart phase led to reduced motion artifacts on the diffusion-weighted MR images and to significantly improved accuracy and reproducibility of measurements ..
  95. ncbi Diffusion imaging in humans at 7T using readout-segmented EPI and GRAPPA
    Robin M Heidemann
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Magn Reson Med 64:9-14. 2010
    ..Readout-segmented echo-planar imaging in conjunction with parallel imaging has the potential to reduce these artifacts by allowing a further reduction in effective echo spacing during the echo-planar imaging readout...
  96. ncbi The correction of ocular artifacts: a topographic perspective
    T W Picton
    Rotman Research Institute, University of Toronto, Ontario, Canada
    Clin Neurophysiol 111:53-65. 2000
    ..To evaluate the scalp topography of the potentials related to saccades and blinks...
  97. pmc Validation of ICA-based myogenic artifact correction for scalp and source-localized EEG
    Brenton W McMenamin
    Department of Psychology, Center for Cognitive Science, University of Minnesota, Twin Cities, Minneapolis, MN, USA
    Neuroimage 49:2416-32. 2010
    ..In light of these results, several practical suggestions and recommendations are made for intelligently using ICA to minimize EMG and other common artifacts.
  98. ncbi Improved quality of auditory event-related potentials recorded simultaneously with 3-T fMRI: removal of the ballistocardiogram artefact
    Stefan Debener
    MRC Institute of Hearing Research Southampton, Royal South Hants Hospital, School of Medicine, University of Southampton, UK
    Neuroimage 34:587-97. 2007
  99. ncbi Multidetector-row computed tomography imaging characteristics of mechanical prosthetic valves
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken Zwolle, The Netherlands
    J Heart Valve Dis 20:216-22. 2011
    ..A pulsatile in vitro model was developed to study the MDCT imaging characteristics of mechanical heart valves (MHVs)...
  100. ncbi Metastatic colorectal cancer KRAS genotyping in routine practice: results and pitfalls
    Aude Lamy
    Laboratory of Tumor Genetics, University Hospital, Rouen, France
    Mod Pathol 24:1090-100. 2011
    ..The tumor heterogeneity observed in some patients indicates that it should be more appropriate to perform KRAS genotyping on metastases if sample is available...
  101. ncbi Hand-held thoracic sonography for detecting post-traumatic pneumothoraces: the Extended Focused Assessment with Sonography for Trauma (EFAST)
    A W Kirkpatrick
    Department of Critical Care Medicine, Foothills Medical Centre, Calgary, Alberta, Canada
    J Trauma 57:288-95. 2004
    ..However, the diagnostic utility of hand-held US has not been previously evaluated in this role...

Research Grants79

  1. Harmonically detected swept source OCT
    Kristen Peterson; Fiscal Year: 2007
    ..optical coherence tomography by achieving noise-limited removal of the complex conjugate ambiguity and other artifacts. Our approach provides better artifact rejection ratios with simpler instrumentation than other methods...
  2. Near Term Development of Reagents and Enzymes for Genome Sequencing
    Steven A Benner; Fiscal Year: 2010
    ..multiplexed priming and PCR with primers having an effective length of 16mers (or longer) without creating PCR artifacts and supporting single nucleotide discrimination, (b) AEGIS tags appended to SAMRS primers that allow binning of ..
  3. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  4. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..recognition is required, yet in the past this has often failed to separate real neurological disorder from artifacts such as movement, eye blinks, and cardiac signals...
  5. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..of wired cables, greatly improving infant comfort, reducing anxiety in visiting parents, and preventing motion artifacts and false alarms caused by moving cables...
  6. Biophysics of Drug Interactions with Viral Episomes
    James K Bashkin; Fiscal Year: 2013
    ..isothermal calorimetry and surface plasmon resonance will allow benchmarking against the literature and avoid artifacts. Aim 2 Footprint the HPV18 genome in vitro with antiviral PAs...
  7. CRCNS: Theory and experiment of neural circuit mapping by DNA sequencing
    Anthony M Zador; Fiscal Year: 2013
    ..models of barcodes jumping across synapses and their post-processing with the goal of identifying potential artifacts. The results of these models will be used for error correction in SA3...
  8. High Fidelity Transcriptome Sequencing Tools
    MICHAEL JOSEPH LODES; Fiscal Year: 2011
    ..of the major NGS platforms and based on the unique qualities of PyroScript RT that will reduce misincorporation artifacts and bias...
  9. Low-cost handheld medical device for neuroaxial anesthesia guidance in the obese
    FRANK WILLIAM MAULDIN; Fiscal Year: 2012
    ..over standard ultrasound due to reduced device cost, greater portability, and mitigation of off-axis reflection artifacts. In addition, this project includes an active shape model-based bone surface position estimation method for ..
  10. Wireless Implantable Monitor for Improved Neuromodulation
    Margot S Damaser; Fiscal Year: 2012
    ..monitor for chronic implantation, creation of an algorithm for differentiating important bladder events from artifacts, validating our micro-packaging method for chronic implantation, and testing of this novel system in a chronic ..
  11. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
    ..for HTS to identify SMI binding to CBP BRD;(2) to evaluate CBP BRD binding SMIs by secondary assays to rule out artifacts by in vitro and in vivo approaches;and (3) to modulate p53 activity between cell growth arrest and apoptosis ..
  12. Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctions
    Walter R T Witschey; Fiscal Year: 2013
    ..will be performed to develop methods to overcome magnetic field heterogeneity (static and RF fields) and motion artifacts associated specifically with T1A cardiac imaging...
  13. Development of a 3D mammotomograph with novel techniques to overcome limitations
    Randolph L McKinley; Fiscal Year: 2010
    ..yields morphological, pseudo-3D images (asymmetric volume image resolution with highly aliased and blurred artifacts) and with otherwise no quantifiable metrics due to the highly insufficiently sampled breast volume...
  14. High throughput assay for fibrin-binding probes
    PETER D CARAVAN; Fiscal Year: 2013
    ..develop secondary screens to confirm compounds active in the primary screen as reproducible hits, and rule out artifacts, as well as develop counter-screening assays to allow prioritization of hits for further testing...
  15. Screens for novel compounds to correct diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2011
    ..In Aim 2, we propose to evaluate hit compounds. Aim 2a will rule out artifacts, establish selectivity for HSPG-mediated uptake, and prioritize compounds...
  16. The Regulation of Plasma Membrane Estrogen Receptor-a Levels by Endocytosis
    Reymundo Dominguez; Fiscal Year: 2012
    ..studying membrane-initiated estradiol signaling have relied heavily on techniques that are subject to artifacts of fixation and tissue disruption...
  17. Multiphoton Fluorescence Lifetime Imaging of Solid Tumors Invivo
    V Krishnan Ramanujan; Fiscal Year: 2010
    ..lifetime is "intrinsic" to the fluorophore and its measurement is not affected by concentration and/or spectral artifacts as in intensity-based methods, (2) multiphoton excitation can enable increased tissue penetrability and reduced ..
  18. State-of-the-Art PET/CT Instrumentation
    Richard E Carson; Fiscal Year: 2010
    ..including image-based measurement of tracer input function and corrections for cardiac and respiratory motion artifacts. The proposed system will support NIH-funded investigators in the Departments of Cardiology, Diagnostic ..
  19. Endovascular Magnetic Catheter for Interventional MRI
    STEVEN WILLIAM HETTS; Fiscal Year: 2013
    ..Specific Aim 2: Evaluate MR imaging strategies to optimize catheter visualization and minimize artifacts; 3. Specific Aim 3: Test catheter navigation and imaging in vitro in the 1.5 T and 3.0 T MRI environments; 4...
  20. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Edward J Vresilovic; Fiscal Year: 2010
    ..Excising the tissue disrupts the fiber structure, which introduces artifacts into the material property measurement and does not represent the inhomogeneities that are reflected by the ..
  21. The Endothelial Glycocalyx: Its Structure and Function and as a Mechanotransducer
    John M Tarbell; Fiscal Year: 2013
    ..Because of dehydration artifacts associated with conventional electron microscopy, even such rudimentary characteristics as the thickness of the ..
  22. PyroMark Q96 MD
    Marisa S Bartolomei; Fiscal Year: 2010
    ..It also less prone to bias artifacts generated when traditional bisulfite mutagenesis, cloning and sequencing techniques are used and provides a more ..
  23. SIMLAB: Using Patient Simulation for Student Exploration of Community Health Issu
    PATRICIA LEAH WARD; Fiscal Year: 2013
    ..The Museum has more than 35,000 artifacts, over 14 acres of hands-on exhibits, and hosts nearly 285,000 student visits annually...
  24. Analysis and Characterization of Trauma-Induced Coagulopathy
    Stephen R Wisniewski; Fiscal Year: 2013
    ..Collection techniques will utilize inhibitory cocktails to block ex vivo, post phlebotomy artifacts. Blood/plasma samples will be shipped to a secure repository and analyzed utilizing new technology to identify ..
  25. HTS to identify chemical probes of the apelin receptor signaling pathway
    Layton Harris Smith; Fiscal Year: 2010
    ..Together these complimentary assay platforms will be used to confirm hits and eliminate format specific artifacts. A counter-screen against another Gai-coupled receptor unrelated to APJ (opiate receptor-like-1) has already ..
  26. Anti-carcinogenic effects of White Tea on Lung Cancer
    Jenny T Mao; Fiscal Year: 2010
    ..of EGCG in our model systems to ensure that WTE-induced antineoplastic effects are not due to in vitro "artifacts." The findings of this proposed study will provide important insights into the anti-neoplastic properties of WTE ..
  27. Animal Model to Study Retinoic Acid Function in Postnatal and Adult Tissues
    GREGG L DUESTER; Fiscal Year: 2012
    ..However, these approaches are more prone to artifacts and misinterpretation compared with gene knockout approaches, and may not reveal an accurate view of postnatal ..
  28. Development &Malleability from Childhood to Adulthood
    Nicholas S Ialongo; Fiscal Year: 2013 are thus likely to provide some of the best genomic controls currently possible to avoid stratification artifacts, the major problem with association genetic studies that might otherwise be a significant issue with the admixed ..
  29. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..specific aims proposed in this research: 1) to design, build, and test a system to reduce corneal birefringence artifacts due to eye motion and elucidate glucose concentration in the presence of other optically active molecules that ..
  30. Quantitative Adenosine Stress CMR with Spiral Pulse Sequences
    Michael Salerno; Fiscal Year: 2013
    ..Current CMR first pass perfusion techniques are limited by "dark-rim" artifacts which may be mistaken for true perfusion abnormalities resulting in false positive studies with visual analysis, ..
  31. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    ..of DBS only after stimulation has been discontinued due to the problems associated with electrical stimulation artifacts. The results from many of these studies have been contradictory, likely secondary to the variety of conditions ..
  32. EnerCage: A Scalable Array of Intelligent Wireless Sensor Modules to Energize and
    Maysam Ghovanloo; Fiscal Year: 2010
    ..substantial limitations on weight, the range over which an animal can traverse, susceptibility to noise, motion artifacts, and the need for expensive commutators to eliminate tangling and twisting...
  33. A Probabilistic Pose Estimation Algorithm for 3D Motion Capture Data
    W Scott Selbie; Fiscal Year: 2011
    ..In this framework, the pose and any prior knowledge about the pose are encoded probabilistically, and the "artifacts and noise" are captured by a generative model, which defines the conditional probability of the data given the ..
  34. PacBio RS Single Molecule, Real-Time (SMRT) DNA Sequencer
    Suzanne Sandmeyer; Fiscal Year: 2012
    ..of the PacBio RS are: 1) no requirement for prior PCR amplification of sample DNA avoids associated problematic artifacts;2) long-range polymerization enables sequencing of regions containing repeats, de novo assembly, and RNA seq of ..
    Mark A Anastasio; Fiscal Year: 2013
    ..In addition, the existing PACT systems suffer from significant motion artifacts. Accordingly, there remains an important need for the development of improved small-animal PACT systems and ..
    Lihong Wang; Fiscal Year: 2011
    ..PAI is also free of speckle artifacts, which exist in optical coherence tomography and ultrasonography...
  37. Functional characterization of pathways regulated by schizophrenia gene TCF4
    JOSEPH LOUIE MCCLAY; Fiscal Year: 2013
    ..Family-based designs preclude the possibility of artifacts due to population stratification...
  38. High-Resolution MicroCT Scanner for Cardiopulmonary Imaging Applications
    Rahim R Rizi; Fiscal Year: 2010 perform prospectively-gated respiratory and cardiac imaging with extremely high precision with reduced motion artifacts in the heart and thorax...
  39. Magnetophoretic Cell Sorting and Analysis
    Maciej Zborowski; Fiscal Year: 2013
    ..imaging capability of the cell tracking hardware and software, and by including corrections for fluid dynamics artifacts in collaboration with an expert in field-flow fractionation (Dr. Williams)...
    Srini Tridandapani; Fiscal Year: 2013
    ..angiography (CTCA), which, in its current forms, is either radiation-intensive or unreliable due to motion artifacts. In Aim 1, the PI will evaluate US-gating relative to ECG-gating in determining relative cardiac quiescence...
  41. Dual Energy Computed Tomography for Determining Coronary Lesion-Specific Ischemia
    James K Min; Fiscal Year: 2013
    ..Early studies of CTP have been constrained by several limitations, including: 1) shading artifacts;2) motion artifacts;3) lack of a quantitative method for assessing perfusion;4 excess radiation;and 5) an ..
  42. End-of-Life Care After Severe Fetal Diagnosis
    Beth Black; Fiscal Year: 2012
    ..Additional data will be collected from medical records, documents and artifacts of pregnancy and delivery...
  43. High Resolution Magnetic Resonance Imaging and Spectroscopy of Epilepsy at 7T
    Priti Balchandani; Fiscal Year: 2012
    ..magnetic and applied RF fields as well as frequency-dependent spatial shifts in the selected volume, result in artifacts for imaging and spectroscopy, limiting the utility of current high-field scanners...
  44. Predicting Radiotherapy Outcomes by Combining Physical and Biological Factors
    ISSAM MUSTAFA EL NAQA; Fiscal Year: 2010 varying doses of the normal lung (dose-volume histogram data, collected using 4-D methods to avoid breathing artifacts), and the spatial location of the high-dose regions, both of which have been correlated with risk of RP...
  45. Quantification and monitoring inflammation in IBD with Molecular Ultrasound
    JUERGEN KARL WILLMANN; Fiscal Year: 2013
    ..g., spatial orientation within the large volume of the bowel, possible artifacts fro intraluminal gas, motion, etc)...
  46. Development of a Practical Non-contact ECG Sensor for Arrhythmia Diagnosis
    Yu M Chi; Fiscal Year: 2012
    ..Unresolved issues relating to cost, complexity, movement artifacts and noise have yet to be adequately solved...
  47. Attomole-Level High-Throughput Genomics
    PATRICE MARIE MILOS; Fiscal Year: 2012
    ..and require multiple nucleic acid manipulation and amplification steps that are known to introduce biases and artifacts that confound downstream analyses and reduce/eliminate quantitative power...
  48. Ultrasound-Induced Pulmonary Hemorrhage During Diagnostic Examination of the Lung
    DOUGLAS LAWRENCE MILLER; Fiscal Year: 2013
    ..6 MHz diagnostic ultrasound (DUS) showed the rapid development comet-tail artifacts across the bright lung surface image...
  49. Sleep Disordered Breathing in normal elderly and risk for Alzheimers Disease
    Ricardo S Osorio; Fiscal Year: 2013
    ..and cerebral blood flow (CBF) using a novel NYU arterial spin labeling (ASL) protocol to avoid susceptibility artifacts, and regional brain vasoreactivity estimates after CO2 breathing (VR-CO2);as well as both plasma and CSF ..
  50. RGR-based motion tracking for real-time adaptive MR imaging and spectroscopy
    THOMAS M ERNST; Fiscal Year: 2012
    ..or subjects who are agitated or confused due to anxiety, drug use or sickness, resulting in data with motion artifacts that could prevent accurate diagnoses or assessments...
  51. Aging and neurovascular regulation of endothelial cell calcium signals, in vivo
    ERIKA MARY BOERMAN; Fiscal Year: 2013
    ..confocal imaging of local EC Ca2+ in vivo without the need for external dyes or concern for their potential artifacts. Using this model to stimulate PVNs before and during selective inhibition of sensory or sympathetic ..
  52. Confocal Photacoustic Microscopy: Technology Development
    Lihong Wang; Fiscal Year: 2011
    ..Furthermore, PAM is free of speckle artifacts, which plague OCT and ultrasonography...
  53. Imaging and stimulation of neural activity at cellular resolution in awake mice
    David W Tank; Fiscal Year: 2012
    ..providing the conditions for an offline Hidden Markov Model based software method for removing residual motion artifacts. Pilot data using a first generation instrument demonstrate that behaviorally correlated calcium transients from ..
  54. Mutational Analysis of Fks1: Intrinsic Echinocandin Resistance
    Thomas D Edlind; Fiscal Year: 2010
    ..and immune to ex"l)ression artifacts. Differential efferu of mlltation~ on ca.<;JlOfUrWn....
  55. Near Infrared Brain Imaging for Guiding Treatment in Children with Cerebral Palsy
    Georgios Alexandrakis; Fiscal Year: 2013 map functional activities in the healthy human motor cortex and is relatively immune from patient motion artifacts, is cost effective, and can be widely deployable in a clinical setting...
  56. Study of fiber anatomy in mouse brain development via MRI/DTI
    Christos Davatzikos; Fiscal Year: 2013
    ..more detailed yet laborious histological analyses, and does not suffer from sectioning and staining distortion artifacts, but provides spatially consistent 3D volumes...
  57. Development of Second Messenger, Trafficking, and Functional Assays for GPR119
    PATRICIA HELEN MCDONALD; Fiscal Year: 2012
    ..developing innovative and novel assays for GPR119 that are HTS compatible, secondary screening assays to triage artifacts, counterscreens to assess selectivity of compounds versus two structurally related GPCRs and functional assays ..
  58. True Direct Single Molecule RNA Sequencing
    PATRICE MARIE MILOS; Fiscal Year: 2012
    ..This step has been shown to introduce many biases and artifacts. In order to best characterize the "true" transcriptome, we propose the application of single molecule, true ..
  59. Harmonically detected swept source OCT
    Kristen A Peterson; Fiscal Year: 2011
    ..optical coherence tomography by achieving noise-limited removal of the complex conjugate ambiguity and other artifacts. Our approach provides better artifact rejection ratios with simpler instrumentation than other methods...
  60. High frequency activity in infants with epilepsy
    JULIA MARIE STEPHEN; Fiscal Year: 2010 not always accompanied by behavioral seizures in infants, it can be measured using MEG without movement artifacts. We will study <3 year old infants for the presence of the HFS and, if found, we will test if the locations ..
  61. Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    Brian E Applegate; Fiscal Year: 2013
    ..FLIM has been shown to be far less susceptible to artifacts endemic to in vivo imaging than steady-state fluorescence...
  62. Automatic 3D Quantification of Synapse Distribution in Complex Dendritic Arbor
    Jie Zhou; Fiscal Year: 2013
    ..and subcellular compartment extraction for overcoming challenges in 3D confocal image, including staining artifacts and anisotropic resolution...
  63. Ultrasound Imaging of Breast by Use of a Hemispheric Array and Inverse Scattering
    Robert C Waag; Fiscal Year: 2013
    ..g., about two seconds, to avoid image-degrading motion artifacts. The planned use of off-line processing by available computing resources for image reconstruction circumvents ..
  64. Raman spectroscopy probes for assisting stereotactic breast biopsy needle placeme
    Stephen Fulghum; Fiscal Year: 2009 see because of dense breast tissue or the lesion may move from its expected position due to compression artifacts of the stereotactic targeting apparatus...
  65. Novel 3D Catheter Tracking System for Intracardiac Navigation
    DORON HARLEV; Fiscal Year: 2009
    ..limitations, including tracking distortions and inadequate correction for respiration and other motion artifacts. The potential consequences of inaccurate catheter tracking include ablation of electrically normal cardiac ..
  66. Functional brain imaging by laser-induced PAT
    Lihong Wang; Fiscal Year: 2007
    ..the proposed technology, functional photoacoustic tomography (fPAT), can image the intact brain free of speckle artifacts. Besides structural information, the proposed fPAT can also provide functional information including blood ..
  67. Engaging Tribal Participation in Research through Priority Setting and Regulation
    RON WHITENER; Fiscal Year: 2010
    ..and Native populations of the United States regarding the collection of Native American remains, cultural artifacts, and access to and use of natural resources, as well as health research...
    David Allison; Fiscal Year: 1999
    ..have suggested that the elevated risk of mortality with low BMI and the increase in the nadir with age are artifacts due to putative confounding variables such as smoking and preexisting "occult" disease...
    PATSY GERSTNER; Fiscal Year: 1991
    ..academic health sciences institutions, primarily libraries, to do on-line cataloguing of approximately 50,000 artifacts in their collections...
  70. Novel Ether Containing Ligand Complexes: Cardiac Imaging
    KEVIN MARESCA; Fiscal Year: 2004
    ..and ischemia, the energy spectrum of thallium- 201 makes it particularly prone to soft tissue attenuation artifacts. While there are two FDA-approved Tc-99m perfusion tracers, having more favorable energy spectra for imaging, ..
  71. Controlling for Endogeneity Biases in Estimating AA Effects on Drinking Outcomes
    Stephen Magura; Fiscal Year: 2010
    ..mainly correlational, studies of Alcoholics Anonymous (AA) effectiveness are susceptible to two main kinds of artifacts due to potential endogeneity bias in variables, defined as when variables treated as exogenous may actually be ..
    John SantaLucia; Fiscal Year: 2001
    ..Gap regions occur because of a variety of sequencing artifacts including mispriming of directed oligonucleotide primers, band-compressions in gel electrophoresis, and the ..
  73. Shared Instrumentation: Vevo 770 Ultrasound System
    David Pollock; Fiscal Year: 2009
    ..Finally, all projects will need to use the in vivo rail system for reducing movement artifacts and maintaining health of the animals during imaging...
  74. Software Systems for Detecting Rare Muations
    Todd Smith; Fiscal Year: 2009
    ..relative to control sequences, with respect to sequence contexts, random noise, laboratory steps, and instrument artifacts. The catalogs will then be used to develop statistical algorithms that can analyze large numbers of aligned ..
  75. Electron Tomography of the Outer Hair Cell Lateral Wall
    WILLIAM TRIFFO; Fiscal Year: 2009
    ..wall structure has been limited to extrapolation from 2D studies of samples, further complicated by preservation artifacts depending on the sample preparation method used...
  76. Quantitative periprosthetic PET/CT
    Thomas Lang; Fiscal Year: 2009
    ..However, CT suffers from severe image artifacts in the presence of metallic implants that not only render the CT images undiagnostic but also negatively ..
  77. Promiscuous and Specific Inhibitors of Cruzain
    Brian Shoichet; Fiscal Year: 2007
    ..Multiple mechanisms have been proposed to explain these artifacts, including chemical reactivity, oxidation, assay interference, and colloidal aggregation...
  78. Development of Methods and Software for Interior Tomography Applications
    Hengyong Yu; Fiscal Year: 2009
    ..When applying conventional CT algorithms to such an incomplete dataset, the features outside the ROI may create artifacts overlapping inside real features...
  79. Development of a Brain Template for Diffusion-Tensor MRI
    Konstantinos Arfanakis; Fiscal Year: 2009
    ..DTI data acquisitions are based on echo- planar imaging (EPI), which suffers from distortions and image artifacts. Furthermore, to increase the accuracy of normalization, all the information of the tensor must be used in the ..