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Genomes and Genes
| body mass indexSummarySummary: An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention) Top Publications
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Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trialR M Hackman
Department of Nutrition, University of California, Davis, CA 95616 8669, USA
Int J Obes (Lond) 30:1545-56. 2006..To determine the safety and efficacy of a dietary supplement with a low dose of ephedra and caffeine in overweight/obese premenopausal female subjects...
Prevalence and trends in obesity among US adults, 1999-2008Katherine M Flegal
National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
JAMA 303:235-41. 2010..The prevalence of obesity increased in the United States between 1976-1980 and 1988-1994 and again between 1988-1994 and 1999-2000...
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexElizabeth K Speliotes
Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
Nat Genet 42:937-48. 2010..To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2...
Establishing a standard definition for child overweight and obesity worldwide: international surveyT J Cole
Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH
BMJ 320:1240-3. 2000..To develop an internationally acceptable definition of child overweight and obesity, specifying the measurement, the reference population, and the age and sex specific cut off points...
Prevalence of high body mass index in US children and adolescents, 2007-2008Cynthia L Ogden
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
JAMA 303:242-9. 2010The prevalence of high body mass index (BMI) among children and adolescents in the United States appeared to plateau between 1999 and 2006.
Prediction of coronary heart disease using risk factor categoriesP W Wilson
Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
Circulation 97:1837-47. 1998....
Body mass index cut offs to define thinness in children and adolescents: international surveyTim J Cole
Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London WC1N 1EH
BMJ 335:194. 2007To determine cut offs to define thinness in children and adolescents, based on body mass index at age 18 years.
The epidemiology of obesityCynthia L Ogden
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
Gastroenterology 132:2087-102. 2007..Among adults, obesity is defined as a body mass index of 30 or greater...
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patientsK Hotta
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
Arterioscler Thromb Vasc Biol 20:1595-9. 2000..We analyzed the plasma adiponectin concentrations in age- and body mass index (BMI)-matched nondiabetic and type 2 diabetic subjects with and without coronary artery disease (CAD)...
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adultsEugenia E Calle
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
N Engl J Med 348:1625-38. 2003..The influence of excess body weight on the risk of death from cancer has not been fully characterized...
Updated definitions of healthy ranges for serum alanine aminotransferase levelsDaniele Prati
Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
Ann Intern Med 137:1-10. 2002..Current standards for "normal" ALT level were defined by using populations that included persons with subclinical liver disease...
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgeryLars Sjöström
Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
N Engl J Med 351:2683-93. 2004..Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown...
Development of a WHO growth reference for school-aged children and adolescentsMercedes de Onis
Department of Nutrition, World Health Organization, Geneva, Switzerland
Bull World Health Organ 85:660-7. 2007To construct growth curves for school-aged children and adolescents that accord with the WHO Child Growth Standards for preschool children and the body mass index (BMI) cut-offs for adults.
The obesity epidemic in the United States--gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysisYoufa Wang
Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Epidemiol Rev 29:6-28. 2007..Adult overweight and obesity were defined by using body mass index (weight (kg)/height (m)(2)) cutpoints of 25 and 30, respectively; childhood "at risk for overweight"..
Waist circumference and not body mass index explains obesity-related health riskIan Janssen
Department of Community Health and Epidemiology, Queen's University, Kingston, Canada
Am J Clin Nutr 79:379-84. 2004BACKGROUND: The addition of waist circumference (WC) to body mass index (BMI; in kg/m(2)) predicts a greater variance in health risk than does BMI alone; however, whether the reverse is true is not known...
Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in womenFrank B Hu
Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 289:1785-91. 2003..Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors...
The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary diseaseBartolome R Celli
COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
N Engl J Med 350:1005-12. 2004..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2R G Walters
Section of Genomic Medicine, Imperial College London, London W12 0NN, UK
Nature 463:671-5. 2010..7% of our morbid obesity cases (body mass index (BMI) >or= 40 kg m(-2) or BMI standard deviation score >or= 4; P = 6.4 x 10(-8), odds ratio 43...
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metforminWilliam C Knowler
Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
N Engl J Med 346:393-403. 2002..9 would have to receive metformin. CONCLUSIONS: Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin...
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaSamar I Itani
Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
Diabetes 51:2005-11. 2002..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
Decreased plasma adiponectin concentrations in women with dyslipidemiaMiyao Matsubara
Division of Endocrinology and Metabolism, Internal Medicine, Otaru City General Hospital, Wakamutsu 1 2 1, Otaru 047 8550, Japan
J Clin Endocrinol Metab 87:2764-9. 2002..and apolipoprotein (apo) levels in 352 nondiabetic women, 16-86 yr old, with a wide range of body weight [body mass index (BMI), 14.8-36.3 kg/m(2)]. Plasma adiponectin concentrations in women with the highest tertile of TG (1...
Long-term weight loss maintenanceRena R Wing
Brown Medical School, The Miriam Hospital, Department of Psychiatry, Providence, RI, USA
Am J Clin Nutr 82:222S-225S. 2005..National Weight Control Registry members provide evidence that long-term weight loss maintenance is possible and help identify the specific approaches associated with long-term success...
Validity of self-reported height and weight in 4808 EPIC-Oxford participantsElizabeth A Spencer
Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
Public Health Nutr 5:561-5. 2002..weight by comparison with measured height and weight in a sample of middle-aged men and women, and to determine the extent of misclassification of body mass index (BMI) arising from differences between self-reported and measured values.
Reducing children's television viewing to prevent obesity: a randomized controlled trialT N Robinson
Department of Pediatrics, Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
JAMA 282:1561-7. 1999..Some observational studies have found an association between television viewing and child and adolescent adiposity...
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001Ali H Mokdad
Division of Adult and Community Health, 4770 National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
JAMA 289:76-9. 2003..Obesity and diabetes are increasing in the United States...
Evidence based physical activity for school-age youthWilliam B Strong
Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
J Pediatr 146:732-7. 2005..To review the effects of physical activity on health and behavior outcomes and develop evidence-based recommendations for physical activity in youth...
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studiesAndrew G Renehan
Department of Surgery, School of Cancer Studies, University of Manchester, UK
Lancet 371:569-78. 2008..We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups...
Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994Stephen Cook
Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Arch Pediatr Adolesc Med 157:821-7. 2003..In adults the metabolic syndrome imposes a substantial risk for type 2 diabetes mellitus and premature coronary heart disease. Even so, no national estimate is currently available of the prevalence of this syndrome in adolescents...
Fasting serum glucose level and cancer risk in Korean men and womenSun Ha Jee
Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
JAMA 293:194-202. 2005..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trialsSeamus P Whelton
Tulane University, New Orleans, Louisiana 70112, USA
Ann Intern Med 136:493-503. 2002..An increase in aerobic physical activity should be considered an important component of lifestyle modification for prevention and treatment of high blood pressure...
Gene X environment interaction of vigorous exercise and body mass index among male Vietnam-era twinsJeanne M McCaffery
Weight Control and Diabetes Research Center, Brown Medical School and The Miriam Hospital, Providence, RI 02903, USA
Am J Clin Nutr 89:1011-8. 2009Secular trends over the past several decades suggest an environmental influence on body mass index (BMI)...
Genotype-phenotype associations in obesity dependent on definition of the obesity phenotypeSofia Inez Iqbal Kring
Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
Obes Facts 1:138-45. 2008..In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort...
Variation in FTO contributes to childhood obesity and severe adult obesityChristian Dina
CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
Nat Genet 39:724-6. 2007..The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses...
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groupsAndre Scherag
Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
PLoS Genet 6:e1000916. 2010..We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults...
Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular diseaseJames B Meigs
General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
J Clin Endocrinol Metab 91:2906-12. 2006..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adultsM Dalton
International Diabetes Institute, Melbourne, Caulfield, Victoria, Australia
J Intern Med 254:555-63. 2003OBJECTIVES: To compare body mass index (BMI), waist circumference and waist-hip ratio (WHR) as indices of obesity and assess the respective associations with type 2 diabetes, hypertension and dyslipidaemia...
Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationshipP Deurenberg
Wageningen University, The Netherlands
Obes Rev 3:141-6. 2002The objective was to study the relationship between body mass index (BMI) and body fat per cent (BF%) in different population groups of Asians. The study design was a literature overview with special attention to recent Asian data...
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traitsYoon Shin Cho
Center for Genome Science, National Institute of Health, Seoul, Korea
Nat Genet 41:527-34. 2009..For height and body mass index, most variants detected overlapped those reported in European samples...
BMI-referenced standards for recommended pedometer-determined steps/day in childrenCatrine Tudor-Locke
Department of Exercise and Wellness, Arizona State University East, Mesa, AZ 85212 0180, USA
Prev Med 38:857-64. 2004..The purpose of the present study was to establish criterion-referenced standards for PA (using pedometer-assessed steps/day) related to healthy body composition...
General and abdominal adiposity and risk of death in EuropeT Pischon
Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
N Engl J Med 359:2105-20. 2008....
Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass indexS C Savva
Research and Education Program of Child Health, Cyprus
Int J Obes Relat Metab Disord 24:1453-8. 2000..Waist measurement and waist-to-height ratio (WHtR) have been used as proxy measures of visceral adipose tissue, mainly in adults...
Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean populationYong Ho Lee
Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong Seodaemun gu, Seoul 120 752, South Korea
J Hum Genet 53:991-8. 2008..rs1111875, rs10811661, rs4402960, rs8050136, rs734312, rs7754840 and rs2237892 and measured the body weight, body mass index and fasting plasma glucose in all patients and controls...
Common body mass index-associated variants confer risk of extreme obesityChris Cotsapas
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Hum Mol Genet 18:3502-7. 2009..We also found evidence of association at a further six of 12 other loci previously reported to influence body mass index (BMI) in the general population and one of three associations to severe childhood and adult obesity and that ..
Impact of overweight on the risk of developing common chronic diseases during a 10-year periodA E Field
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Arch Intern Med 161:1581-6. 2001..Overweight adults are at an increased risk of developing numerous chronic diseases...
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO geneKarani S Vimaleswaran
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
Am J Clin Nutr 90:425-8. 2009Intronic variation in the FTO (fat mass and obesity-associated) gene has been unequivocally associated with increased body mass index (BMI; in kg/m(2)) and the risk of obesity in populations of different ethnicity.
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysisKerstin Wahlen
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
J Lipid Res 49:607-11. 2008..in relation to fat cell function and adipose tissue gene expression in 306 healthy women with a wide range in body mass index (18-53 kg/m(2))...
The effects of maternal body mass index on pregnancy outcomeA S Khashan
The Anu Research Centre, Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland
Eur J Epidemiol 24:697-705. 2009..We examined the effect of Body Mass Index in early pregnancy on adverse pregnancy outcome...
Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk--a review of the literatureR Huxley
Renal and Metabolic Division, The George Institute for International Health, The University of Sydney, Sydney, Australia
Eur J Clin Nutr 64:16-22. 2010..Traditionally, body mass index (BMI) has been the most widely used method by which to determine the prevalence of overweight in, and across, ..
Life course variations in the associations between FTO and MC4R gene variants and body sizeRebecca Hardy
MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
Hum Mol Genet 19:545-52. 2010The timing of associations between common genetic variants for weight or body mass index (BMI) across the life course may provide insights into the aetiology of obesity...
Structural brain differences and cognitive functioning related to body mass index in older femalesKatrin Walther
Department of Psychology, University of Arizona, Tucson, Arizona 85721 0068, USA
Hum Brain Mapp 31:1052-64. 2010..This study examined the association between body mass index (BMI), regional volume differences in gray and white matter measured by magnetic resonance imaging (MRI), and ..
Characteristics of physical activities in daily life in chronic obstructive pulmonary diseaseFabio Pitta
Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
Am J Respir Crit Care Med 171:972-7. 2005..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysisCrystal Man Ying Lee
Nutrition and Lifestyle Division, The George Institute for International Health, University of Sydney, PO Box M 201, Missenden Road, Sydney NSW 2050, Australia
J Clin Epidemiol 61:646-53. 2008..To determine which simple index of overweight and obesity is the best discriminator of cardiovascular risk factors...
Risk factors for childhood overweight: shift of the mean body mass index and shift of the upper percentiles: results from a cross-sectional studyA Beyerlein
Ludwig Maximilians University of Munich, Institute of Social Paediatrics and Adolescent Medicine, Division of Epidemiology, Munich, Germany
Int J Obes (Lond) 34:642-8. 2010..increasing prevalence of childhood overweight seems to be due to an increasing proportion of extremely high body mass index (BMI) values rather than to a shift of the entire BMI distribution...
Meta-analysis: the effect of dietary counseling for weight lossMichael L Dansinger
Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Ann Intern Med 147:41-50. 2007..Dietary and lifestyle modification efforts are the primary treatments for people who are obese or overweight. The effect of dietary counseling on long-term weight change is unclear...
The prevalence and impact of overweight and obesity in an Australian obstetric populationLeonie K Callaway
E Floor, Clinical Sciences Building, Royal Brisbane and Women s Hospital, Herston QLD 4029, Australia
Med J Aust 184:56-9. 2006..To assess the prevalence and impact of overweight and obesity in an Australian obstetric population...
Gestational weight gain and child adiposity at age 3 yearsEmily Oken
Obesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Am J Obstet Gynecol 196:322.e1-8. 2007..The purpose of this study was to examine the associations of gestational weight gain with child adiposity...
Using pedometers to increase physical activity and improve health: a systematic reviewDena M Bravata
Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA
JAMA 298:2296-304. 2007..Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity...
Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceW Timothy Garvey
Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes 52:453-62. 2003..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart StudyCaroline S Fox
National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
Circulation 116:39-48. 2007..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002Allison A Hedley
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA
JAMA 291:2847-50. 2004..The prevalence of overweight and obesity has increased markedly in the last 2 decades in the United States...
Obesity, obstetric complications and cesarean delivery rate--a population-based screening studyJoshua L Weiss
Division of Maternal Fetal Medicine, Columbia Presbytrian Medical Center, New York, NY 10032, USA
Am J Obstet Gynecol 190:1091-7. 2004..This study was undertaken to determine whether obesity is associated with obstetric complications and cesarean delivery...
Fetal origins of adult disease: strength of effects and biological basisD J P Barker
Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
Int J Epidemiol 31:1235-9. 2002....
Relationship between body mass index and gray matter volume in 1,428 healthy individualsYasuyuki Taki
Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer IDAC, Tohoku University, Sendai, Japan
Obesity (Silver Spring) 16:119-24. 2008....
Prescreening tools for diabetes and obesity-associated dyslipidaemia: comparing BMI, waist and waist hip ratio. The D.E.S.I.R. StudyB Balkau
INSERM, U258, Villejuif, France
Eur J Clin Nutr 60:295-304. 2006..To compare the sensitivities of BMI, waist circumference and waist hip ratio (WHR) in identifying subjects who should be screened for diabetes and/or for obesity-associated dyslipidaemia...
Insulin resistance in obese adolescentsHsing-Jung Li
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan
Acta Paediatr Taiwan 46:61-6. 2005..Height, weight and body mass index (BMI) were measured and each was expressed as a standard deviation score (SDS) based on national growth ..
[Cardiovascular risk and metabolic profile in obese children and adolescents with low insulin sensitivity]Raquel Burrows
Area de Nutrición Humana, INTA, Universidad de Chile
Rev Med Chil 133:795-804. 2005..Insulin resistance is a central mechanism of complications of obesity and is associated to body fat mass...
Effect of diet and physical exercise treatment on insulin resistance syndrome of schoolchildrenAnna Szamosi
2nd Department of Pediatrics, Medical Faculty, Semmelweis University, H 1094 Budapest Tüzoltóu, 7, Hungary
J Am Coll Nutr 27:177-83. 2008..Insulin resistance syndrome (IRS) of schoolchildren may contribute to cardiovascular diseases (CVD) of young adults. The investigation of different steps, baseline screening parameters and treatment of IRS may help the prevention...
Nutrient-stimulated glucagon-like peptide 1 release after body-weight loss and weight maintenance in human subjectsTanja C M Adam
Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University PO Box 616, 6200 MD Maastricht, The Netherlands
Br J Nutr 95:160-7. 2006..8 (sd 2.9)) and T3 (11.1 (sd 1.5)). Since we found a rebound of concentrations after a weight-maintenance period, decrease after weight loss seems to be transient and possibly due to a negative energy balance...
Growth patterns of Qatari school children and adolescents aged 6-18 yearsAbdulbari Bener
Department of Medical Statistics and Epidemiology, Hamad General Hospital, Hamad Medical Corporation, University of Qatar, Doha
J Health Popul Nutr 23:250-8. 2005..Of 7442 Qatari children studied, 50.3% were male and 49.7%' female. The mean values for height, weight, and body mass index (BMI) increased with the age for both boys and girls until the age of 18 years, except BMI, which stabilized ..
Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factorsT S Burgert
Department of Pediatrics and the General Clinical Research Center, Yale University School of Medicine, New Haven 06520, USA
Int J Obes (Lond) 30:273-80. 2006..While the mechanisms behind this association remain to be established, most studies suggest that MA is the result of increased vascular leakage denoting endothelial dysfunction associated with early vasculopathy...
[Obesity related complications in children and adolescents]Piotr Fichna
Klinika Endokrynologii i Diabetologii Wieku Rozwojowego II Katedry Pediatrii AM im Karola Marcinkowskiego w Poznaniu, Poznan
Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 12:223-8. 2006..Many disturbances can be reversed at the early stage, if even small weight loss is achieved...
Factors associated with misperception of weight in the stroke beltEileen C Miller
Department of Public Health Education, University of North Carolina Greensboro, Greensboro, NC 27402 6170, USA
J Gen Intern Med 23:323-8. 2008..Understanding the reasons for overweight and obesity is critical to addressing the obesity epidemic. Often the decision to lose weight is based as much on one's self-perception of being overweight as on inherent health benefits...
[Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population]U A Zakel
Center of Child and Adolescent Medicine, Justus Liebig University of Giessen, Giessen, Germany
Klin Padiatr 217:244-9. 2005..The prevalence of childhood obesity is steadily increasing. Weight regulation and food intake are subject to complex regulatory mechanisms. The leptinergic-melanocortinergic system is known to be of major importance...
Type 2 diabetes and metabolic syndrome in Filipina-American women : a high-risk nonobese populationMaria Rosario G Araneta
Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, California 92093-0607, USA
Diabetes Care 25:494-9. 2002..The high prevalence of diabetes in populations who are not of Northern European ancestry may be missed when they are not obese by Western standards...
High birth weight and early postnatal weight gain protect obese children and adolescents from truncal adiposity and insulin resistance: metabolically healthy but obese subjects?Natacha Bouhours-Nouet
Department of Pediatric Endocrinology, University Hospital, 4 rue Larrey, 49000 Angers, France
Diabetes Care 31:1031-6. 2008..We sought to clarify the effects of high birth weight (HBW) and postnatal weight gain on insulin resistance...
First nationwide survey of prevalence of overweight, underweight, and abdominal obesity in Iranian adultsMohsen Janghorbani
School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
Obesity (Silver Spring) 15:2797-808. 2007..The goal was to estimate the prevalence of overweight, obesity, underweight, and abdominal obesity among the adult population of Iran...
Significance of acanthosis nigricans in childhood obesityTulay Guran
Marmara University, Faculty of Medicine, Department of Pediatric Endocrinology, Istanbul, Turkey
J Paediatr Child Health 44:338-41. 2008..Acanthosis nigricans (AN) is among the most common dermatologic manifestations of obesity and hyperinsulinism. In this study, we aimed to find the clinical and laboratory differences in obese children with AN and without AN (non-AN)...
Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn StudyMarieke B Snijder
Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije University, Amsterdam, Netherlands
Am J Clin Nutr 85:989-95. 2007..Dairy consumption has been postulated to reduce the risk of obesity and metabolic disturbances...
Effects of swim training on body weight, carbohydrate metabolism, lipid and lipoprotein profileH Tanaka
Exercise Science Unit, University of Tennessee-Knoxville, Knoxville, TN 37996-2700, USA
Clin Physiol 17:347-59. 1997..Body mass, body fat percentage (36 +/- 2% vs. 35 +/- 2%) and body mass index, as well as regional adiposity, showed no statistically significant changes...
Insulin resistance, beta-cell function, and glucose tolerance in Brazilian adolescents with obesity or risk factors for type 2 diabetes mellitusRegina Cintra Querino da Silva
Diabetes Center of Universidade Federal de São Paulo, Sao Paulo, Brazil
J Diabetes Complications 21:84-92. 2007..To evaluate insulin resistance (IR), beta-cell function, and glucose tolerance in 119 Brazilian adolescents with obesity or risk factors (RF) for type 2 diabetes mellitus (T2DM)...
Anthropometric determinants of a clustering of lipid-related metabolic risk factors in overweight and non-overweight adolescents--influence of cardiorespiratory fitness. The Avena studyJose L Mesa
Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain
Ann Nutr Metab 50:519-27. 2006....
A study of cardiovascular risk in overweight and obese people in EnglandSimon de Lusignan
Primary Care Informatics, Division of Community Health Sciences, St George s University of London, London, UK
Eur J Gen Pract 12:19-29. 2006..To report current levels of obesity and associated cardiac risk using routinely collected primary care computer data...
Changes in hepatic risk factors, metabolic variables, body composition, and physical fitness in obese children after a one-year weight loss programTilman R Rohrer
Department of Paediatrics and Neonatology, Saarland University Hospital, Homburg Saar, Germany
J Pediatr Endocrinol Metab 21:837-45. 2008..05). Weight loss reduced risk factors for liver disease and improved insulin sensitivity. Body composition proved useful as a non-invasive indicator for insulin sensitivity...
Growth curves of anthropometric indices in a general population of French children and comparison with reference dataB Heude
INSERM Unité 780 IFR69, Faculte de Medecine Paris Sud, Villejuif Cedex, France
Eur J Clin Nutr 60:1430-6. 2006..The description of growth patterns of the different anthropometric measurements mainly used in epidemiological studies is useful to better understand the development of obesity in children and its consequences...
Body mass index, waist circumference, and chronic disease risk factors in Australian adolescentsElizabeth Denney-Wilson
NSW Centre for Overweight and Obesity, Level 2, Medical Foundation Bldg K25, University of Sydney, Sydney, New South Wales, Australia 2006
Arch Pediatr Adolesc Med 162:566-73. 2008To determine the association between measures of adiposity (body mass index and waist circumference) and risk factors for heart disease, type 2 diabetes, fatty liver disease, and the clustering of risk factors in middle adolescence.
Changing our future: obesity and the metabolic syndrome in children and adolescentsJoanne S Harrell
School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7460, USA
J Cardiovasc Nurs 21:322-30. 2006..Preventing and managing the metabolic syndrome should be a family matter, and the necessary lifestyle changes will benefit the entire family...
Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceió, north-eastern BrazilTelma T Florêncio
Department of Nutrition, Federal University of Alagoas, Maceio, AL, Brazil
Eur J Cardiovasc Prev Rehabil 14:346-8. 2007..To test the hypothesis that short stature is associated with abdominal obesity, insulin resistance and lipid profile changes...
Regulation of ghrelin is related to estimated insulin sensitivity in obese childrenK Krohn
Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich, Germany
Int J Obes (Lond) 30:1482-7. 2006..CONCLUSIONS: Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI...
Who is maintaining weight in a middle-aged population in Sweden? A longitudinal analysis over 10 yearsAnne N Nafziger
Epidemiology and Public Health Sciences, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
BMC Public Health 7:108. 2007..The aim of this study is to characterize who is not gaining weight during a 10 year period in Sweden...
Overweight and obesity among Norwegian schoolchildren: changes from 1993 to 2000Lene Frost Andersen
Department of Nutrition, University of Oslo, Norway
Scand J Public Health 33:99-106. 2005....
[Metabolic factors in school children population associated with adult cardiovascular mortality. Four provinces' study]Carmen Garces
Unidad de Lipidos, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spain
Med Clin (Barc) 118:767-70. 2002..We have examined certain anthropometric and biochemical variables in children aged 6-7 years from four Spanish provinces with high differences in mortality due to ischemic heart disease (IHD)...
Relation of leptin to insulin resistance syndrome in childrenJulia Steinberger
Department of Pediatrics, University of Minnesota Medical School, University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, USA
Obes Res 11:1124-30. 2003..To examine the relation of leptin to insulin resistance, as measured by euglycemic insulin clamp, and insulin resistance syndrome factors in thin and heavy children...
Relationship between body composition and blood pressure in Bahraini adolescentsAneesa M Al-Sendi
College of Health Science, Ministry of Health, Bahrain
Br J Nutr 90:837-44. 2003..These findings together with the known tracking of BP from adolescence into adulthood underline the importance of establishing intervention programmes in order to prevent the development of childhood and adolescent obesity...
Overweight Japanese with body mass indexes of 23.0-24.9 have higher risks for obesity-associated disorders: a comparison of Japanese and MongoliansK Shiwaku
Department of Environmental and Preventive Medicine, Shimane Medical University, Izumo, Japan
Int J Obes Relat Metab Disord 28:152-8. 2004..to analyze parameters constituting obesity-associated disorders in overweight Japanese and Mongolians with a body mass index (BMI) of 23.0-24...
[Cardiovascular risk factors in overweight and obesity. Changes after a weight loss treatment]Inmaculada Bautista-Castaño
Departamento de Ciencias Clínicas Universidad de Las Palmas de Gran Canaria Las Palmas de Gran Canaria España
Med Clin (Barc) 121:485-91. 2003..The objective of this study was to assess the relationship between body mass index (BMI) and CRF, and the effect of a weight loss program on overweight subjects.
Use of metabolic markers to identify overweight individuals who are insulin resistantTracey McLaughlin
Stanford University School of Medicine, Stanford, California 94305, USA
Ann Intern Med 139:802-9. 2003..SETTING: General clinical research center. PATIENTS: 258 nondiabetic, overweight volunteers. MEASUREMENTS: Body mass index; fasting glucose, insulin, lipid and lipoprotein concentrations; and insulin-mediated glucose disposal as ..
Contribution of weight cycling to serum leptin in human obesityZ L Benini
Clinical Nutrition Laboratory, Istituto Auxologico Italiano, Piancavallo, Verbania, Italy
Int J Obes Relat Metab Disord 25:721-6. 2001..SUBJECTS: One hundred and twenty-eight obese patients (89 females and 39 males), aged 18-61 y, body mass index (BMI) 31.2-63.4 kg/m(2)...
Alcohol consumption in the severely obese: relationship with the metabolic syndromeJohn B Dixon
Monash University Department of Surgery, Alfred Hospital, Melbourne, Victoria, Australia
Obes Res 10:245-52. 2002..The aim of this study was to examine the association between the clinical and biochemical features of the metabolic syndrome and quantity and type of alcohol intake in the severely obese...
Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity, and fatty acids in type 2 diabetesDavid E Kelley
Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Diabetes Care 27:33-40. 2004....
The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivityMartha L Cruz
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
J Clin Endocrinol Metab 89:108-13. 2004..Improving insulin resistance may be crucial for the prevention of chronic disease in this at-risk population...
The interrelationship between insulin secretion and action in type 2 diabetes mellitus with different degrees of obesity: evidence supporting central obesityB Susleyici Duman
Department of Medical Biology and Genetics, Kadir Has University, School of Medicine, Vefa Bey Sok No 5, 80810 Gayrettepe Istanbul, Turkey
Diabetes Nutr Metab 16:243-50. 2003..tolerance test (OGTT), in 156 age- and sex-matched T2DM patients divided in 4 groups according to their body mass index (BMI, I = 20.0-24.9, II = 25.0-29.9, III = 30.0-39.9 and IV > 40.0 kg/m2)...
Research Grants
- Weight management for improved pregnancy outcomesVictor J Stevens; Fiscal Year: 2010..More than 1/3 of women in the U.S. are now starting their pregnancies with a body mass index or 30 or greater, a condition that was unusual to rare 50 years ago...
- Sleep deprivation and energy balanceMarie Pierre St Onge; Fiscal Year: 2009..correlates with overweight and obesity, such that individuals with short sleep periods tend to have a higher body mass index (BMI) than those who sleep 8-9 h/night. The mechanism for this relationship is currently unknown...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2009..test tagSNPs in each of these candidate eCB/CB1 signaling genes for association with 12 quantitative traits: body mass index (BMI), waist circumference, hip circumference, waist/hip ratio (WHR), fasting glucose, insulin, insulin/..
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2010..test tagSNPs in each of these candidate eCB/CB1 signaling genes for association with 12 quantitative traits: body mass index (BMI), waist circumference, hip circumference, waist/hip ratio (WHR), fasting glucose, insulin, insulin/..
- Genetic Instability & Risk for Esophageal CarcinomaXifeng Wu; Fiscal Year: 2009..profiles will be obtained by personal interview on smoking history, alcohol consumption, dietary intake, body mass index (BMI), physical activity, cancer family history, occupational exposures, previous medical history, and ..
- Mediators of Atherosclerosis in South Asians Living in AmericaAlka M Kanaya; Fiscal Year: 2010..of atherosclerosis, diabetes, hypertension, and cardiovascular disease in this ethnic group, despite low body mass index. However, there are no longitudinal studies of South Asians to determine other risk factors that may explain ..
- Television Advertising and Children's Diet Activity and Obesity PrevalenceLisa Powell; Fiscal Year: 2010..service healthy diet and physical activity (HDPA) health promotion messages, and diet, physical activity, body mass index (BMI) and obesity among children and youth. The overwhelming majority (97...
- Weight management for improved pregnancy outcomesVictor Stevens; Fiscal Year: 2009..More than 1/3 of women in the U.S. are now starting their pregnancies with a body mass index or 30 or greater, a condition that was unusual to rare 50 years ago...
- HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*Lennox Jeffers; Fiscal Year: 2004..treatment and week 24 post-treatment) response patterns, as well as, hepatic histology activity index (HAI), Body Mass Index (BMI) and demographic (e.g., age, gender, education, income level) and psychosocial factors (e.g...
- Antidepressant Treatment and Risk of ObesityDavid Arterburn; Fiscal Year: 2009..In 2002, the prevalence of obesity (defined as a body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] of e 30) among US adults ..
- Antidepressant Treatment and Risk of ObesityDAVID ERIC ARTERBURN; Fiscal Year: 2010..In 2002, the prevalence of obesity (defined as a body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] of e 30) among US adults ..
- METABOLICALLY NORMAL AND ABNORMAL OBESITYSamuel Klein; Fiscal Year: 2010..in liver, muscle and adipose tissue and increased VLDL-triglyceride [VLDL-TG] secretion rate), independent of body mass index (BMI), percent body fat, and visceral fat mass...
- Memory, Thiamine Levels, and Brain Structure in Heart FailureMary Woo; Fiscal Year: 2009..thiamine levels, short-term memory, and mammillary body volumes and clinical characteristics (age, LVEF, body mass index, number of re-hospitalizations for HF in 6 months)...
- Adipokines in Hemodialysis PatientsSrinivasan Beddhu; Fiscal Year: 2009In contrast to the non-uremic population, high body mass index (BMI) has been shown to be associated with better survival in dialysis patients and hence fat is considered to be beneficial in dialysis patients...
- Adipokines in Hemodialysis PatientsSrinivasan Beddhu; Fiscal Year: 2010In contrast to the non-uremic population, high body mass index (BMI) has been shown to be associated with better survival in dialysis patients and hence fat is considered to be beneficial in dialysis patients...
- Can diet- & exercise-induced weight loss improve asthma control in obese adults?Jun Ma; Fiscal Year: 2009..We will randomize 324 patients ages 18-70 years who have suboptimally controlled, persistent asthma and a body mass index of 30.0 to 39...
- Can diet- & exercise-induced weight loss improve asthma control in obese adults?Jun Ma; Fiscal Year: 2009..We will randomize 324 patients ages 18-70 years who have suboptimally controlled, persistent asthma and a body mass index of 30.0 to 39...
- Genetic Architecture of Adiposity in Multiple Large CohortsKari E North; Fiscal Year: 2010..5% of trait variance. We propose to extend the meta-analysis approach of these cohorts to investigate body mass index (BMI, wt/ht2), waist circumference (WC), waist-hip ratio (WHR), obesity (BMI>30 kg/m2) and extreme obesity ..
- Neighborhood Environments and Disparities in Obesity Rates in New York CityAndrew G Rundle; Fiscal Year: 2010..that neighborhood characteristics such as urban design features and neighborhood socioeconomic status predict body mass index (BMI)...
- Economic Contextual Influences on Population Diet and ObesityLisa Powell; Fiscal Year: 2010..and chips), beverage (soda) and restaurant state sales taxes and food consumption patterns, diet quality, body mass index (BMI) and obesity prevalence among children, adolescents, and adults...
- Economic Contextual Influences on Population Diet and ObesityLisa Powell; Fiscal Year: 2009..and chips), beverage (soda) and restaurant state sales taxes and food consumption patterns, diet quality, body mass index (BMI) and obesity prevalence among children, adolescents, and adults...
- An analysis of environmental risk factors for obesityWalker Poston; Fiscal Year: 2007..In the proposed study, we will collect both individual-level health data including weight and body mass index (BMI), status on other health conditions and behaviors, as well information on the density of social ..
- Sleep deprivation and energy balanceMarie Pierre St Onge; Fiscal Year: 2010..correlates with overweight and obesity, such that individuals with short sleep periods tend to have a higher body mass index (BMI) than those who sleep 8-9 h/night. The mechanism for this relationship is currently unknown...
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..of age, women postmenopausal and less than 65) with LDL C values greater than or equal to 130 mg/dI and a body mass index greater than or equal to 28 and less than 38 kg/m2...
- Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent WeightJoan Lappe; Fiscal Year: 2009..We propose a 1-year intervention in 13- and 14-year old girls who are above the 50th percentile for body mass index (BMI) and are at least 1= years post- menarche to determine if we can prevent excessive BF gain...
- HYPOTHALAMIC CONTROL OF FEEDING AND METABOLISMROGER CONE; Fiscal Year: 2003..Obesity, as defined by a body mass index above 25, increased from an incidence of 24% in 1980 to 33% in 1990 in a large representative sample in the ..
- Experimental analysis of price changes and food purchases in obese and lean motheLeonard H Epstein; Fiscal Year: 2010..The goal of this application is to study whether income, body mass index (BMI), relative reinforcing value of food (RRV) and impulsivity moderate the effects of prices on energy and ..
- Chicago Healthy Aging Low Risk MRI Angiography (CHARISMA) StudyDONALD M contact LLOYD JONES; Fiscal Year: 2010..CVD), defined by no smoking, lack of diabetes, low total cholesterol levels, low blood pressure, and lean body mass index. Compared with individuals with not-LR status, those with LR status in young adulthood/middle age (<50 ..
- Impact of Malnutrition on HIV Treatment Failure in Resource-Limited SettingsAmita Gupta; Fiscal Year: 2010..Early treatment failure is associated with low CD4 count, low body mass index, and anemia, but these markers are nonspecific and could reflect advanced HIV, co-infections, and/or ..
- Chicago Healthy Aging Low Risk MRI Angiography (CHARISMA) StudyDonald Lloyd Jones; Fiscal Year: 2009..CVD), defined by no smoking, lack of diabetes, low total cholesterol levels, low blood pressure, and lean body mass index. Compared with individuals with not-LR status, those with LR status in young adulthood/middle age (<50 ..
- Impact of Malnutrition on HIV Treatment Failure in Resource-Limited SettingsAmita Gupta; Fiscal Year: 2009..Early treatment failure is associated with low CD4 count, low body mass index, and anemia, but these markers are nonspecific and could reflect advanced HIV, co-infections, and/or ..
- A randomized trial of bariatric surgery for the treatment of sleep apneaSanjay R Patel; Fiscal Year: 2010..We will recruit 80 patients with severe OSA and morbid obesity (body mass index, BMI, of 35-40 kg/m2) from two large clinical sleep programs that together care for a wide spectrum and ..
- Impact of HIV, Antiretroviral Therapy and TB Genotype on Survival in MDR TBNEEL RAJNIKANT GANDHI; Fiscal Year: 2010..Similarly, certain host factors, such as disseminated TB, immunosuppression, or low body mass index, which are more common in HIV, are independently associated with poor MDR TB outcomes and may worsen survival ..
- Amino Acids, Protein, and BMI in Adults Across CulturesKa He; Fiscal Year: 2007..associations, cross-sectional or longitudinal, between intakes of specific amino acids (AA) or protein and body mass index (BMI)...
- Biobehavioral Cardiovascular Health Promotion Intervention in a State Prison SystDebra Moser; Fiscal Year: 2009..Mortality Risk Index [a composite index that includes heart rate, blood pressure, diabetes, smoking status, body mass index, age, and cardio-respiratory fitness], lipid profile, and modifiable lifestyle behaviors) in 4 Kentucky ..
- Aminosterol MSI-1436 as a Therapeutic for ObesityMichael McLane; Fiscal Year: 2004..Today, 64.5 percent of adult Americans (about 127 million) are categorized as being overweight (body mass index >25) or obese (body mass index >30)...
- Technology to Improve Assessment of Physical ActivityJohn Jakicic; Fiscal Year: 2005..body size impact the accuracy of the KAL-X Sensor, we will recruit equal numbers of men and women from three body mass index categories (20-24.9 kg/m 2, 25-29.9 kg/m 2, 30-35 kg/m2)...
- Addressing Health Literacy and Numeracy to Prevent Childhood ObesityRussell Rothman; Fiscal Year: 2009..incorrect mixing of infant formula, difficulty understanding food labels and portion sizes, and higher Body Mass Index (BMI) in adults and children...
