body mass index

Summary

Summary: An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)

Top Publications

  1. pmc Establishing a standard definition for child overweight and obesity worldwide: international survey
    T J Cole
    Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH
    BMJ 320:1240-3. 2000
  2. ncbi Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 307:491-7. 2012
  3. ncbi Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    Cynthia L Ogden
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    JAMA 307:483-90. 2012
  4. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  5. ncbi Prevalence and trends in obesity among US adults, 1999-2008
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 303:235-41. 2010
  6. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
  7. ncbi National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants
    Mariel M Finucane
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Lancet 377:557-67. 2011
  8. pmc Development of a WHO growth reference for school-aged children and adolescents
    Mercedes de Onis
    Department of Nutrition, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 85:660-7. 2007
  9. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  10. ncbi Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4336, Hyattsville, MD 20782, USA
    JAMA 309:71-82. 2013

Detail Information

Publications257 found, 100 shown here

  1. pmc Establishing a standard definition for child overweight and obesity worldwide: international survey
    T J Cole
    Department of Epidemiology and Public Health, Institute of Child Health, London WC1N 1EH
    BMJ 320:1240-3. 2000
    ..To develop an internationally acceptable definition of child overweight and obesity, specifying the measurement, the reference population, and the age and sex specific cut off points...
  2. ncbi Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 307:491-7. 2012
    Between 1980 and 1999, the prevalence of adult obesity (body mass index [BMI] ≥30) increased in the United States and the distribution of BMI changed. More recent data suggested a slowing or leveling off of these trends.
  3. ncbi Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010
    Cynthia L Ogden
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    JAMA 307:483-90. 2012
    ..The prevalence of childhood obesity increased in the 1980s and 1990s but there were no significant changes in prevalence between 1999-2000 and 2007-2008 in the United States...
  4. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  5. ncbi Prevalence and trends in obesity among US adults, 1999-2008
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4315, Hyattsville, MD 20782, USA
    JAMA 303:235-41. 2010
    ..The prevalence of obesity increased in the United States between 1976-1980 and 1988-1994 and again between 1988-1994 and 1999-2000...
  6. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2...
  7. ncbi National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants
    Mariel M Finucane
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Lancet 377:557-67. 2011
    ..However, few worldwide comparative analyses of long-term trends of body-mass index (BMI) have been done, and none have used recent national health examination surveys. We estimated worldwide trends in population mean BMI...
  8. pmc Development of a WHO growth reference for school-aged children and adolescents
    Mercedes de Onis
    Department of Nutrition, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 85:660-7. 2007
    To construct growth curves for school-aged children and adolescents that accord with the WHO Child Growth Standards for preschool children and the body mass index (BMI) cut-offs for adults.
  9. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  10. ncbi Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, 3311 Toledo Rd, Room 4336, Hyattsville, MD 20782, USA
    JAMA 309:71-82. 2013
    ..Estimates of the relative mortality risks associated with normal weight, overweight, and obesity may help to inform decision making in the clinical setting...
  11. ncbi Prevalence of high body mass index in US children and adolescents, 2007-2008
    Cynthia L Ogden
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 303:242-9. 2010
    The prevalence of high body mass index (BMI) among children and adolescents in the United States appeared to plateau between 1999 and 2006.
  12. ncbi Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    Eugenia E Calle
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta 30329, USA
    N Engl J Med 348:1625-38. 2003
    ..The influence of excess body weight on the risk of death from cancer has not been fully characterized...
  13. ncbi Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    Ali H Mokdad
    Division of Adult and Community Health, 4770 National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    JAMA 289:76-9. 2003
    ..Obesity and diabetes are increasing in the United States...
  14. pmc Body mass index cut offs to define thinness in children and adolescents: international survey
    Tim J Cole
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London WC1N 1EH
    BMJ 335:194. 2007
    To determine cut offs to define thinness in children and adolescents, based on body mass index at age 18 years.
  15. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  16. ncbi Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    Andrew G Renehan
    Department of Surgery, School of Cancer Studies, University of Manchester, UK
    Lancet 371:569-78. 2008
    ..We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups...
  17. pmc Body-mass index and mortality among 1.46 million white adults
    Amy Berrington de Gonzalez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    N Engl J Med 363:2211-9. 2010
    ....
  18. ncbi Obesity in children and young people: a crisis in public health
    T Lobstein
    IASO International Obesity TaskForce, 231 North Gower Street, London NW1 2NS, UK
    Obes Rev 5:4-104. 2004
  19. ncbi Evidence based physical activity for school-age youth
    William B Strong
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
    J Pediatr 146:732-7. 2005
    ..To review the effects of physical activity on health and behavior outcomes and develop evidence-based recommendations for physical activity in youth...
  20. ncbi A comparison of direct vs. self-report measures for assessing height, weight and body mass index: a systematic review
    S Connor Gorber
    Physical Health Measures Division, Statistics Canada, Ottawa, ON, Canada
    Obes Rev 8:307-26. 2007
    ..the agreement between objective (measured) and subjective (reported) measures in assessing height, weight and body mass index (BMI)...
  21. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants...
  22. ncbi The obesity epidemic in the United States--gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis
    Youfa Wang
    Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Epidemiol Rev 29:6-28. 2007
    ..Adult overweight and obesity were defined by using body mass index (weight (kg)/height (m)(2)) cutpoints of 25 and 30, respectively; childhood "at risk for overweight" and ..
  23. pmc Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
    Chiara Sabatti
    Department of Human Genetics and Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 41:35-46. 2009
    ..triglycerides, high-density lipoprotein, low-density lipoprotein, glucose, insulin, C-reactive protein, body mass index, and systolic and diastolic blood pressure) in the Northern Finland Birth Cohort 1966 (NFBC1966), drawn from ..
  24. ncbi Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity
    T J Cole
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Pediatr Obes 7:284-94. 2012
    The international (International Obesity Task Force; IOTF) body mass index (BMI) cut-offs are widely used to assess the prevalence of child overweight, obesity and thinness...
  25. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  26. ncbi Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old
    Kenneth F Adams
    Nutritional Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 355:763-78. 2006
    ..0 or more, is associated with an increased risk of death, but the relation between overweight (a BMI of 25.0 to 29.9) and the risk of death has been questioned...
  27. ncbi Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies
    Floriana S Luppino
    Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arch Gen Psychiatry 67:220-9. 2010
    ..Association between obesity and depression has repeatedly been established. For treatment and prevention purposes, it is important to acquire more insight into their longitudinal interaction...
  28. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  29. pmc FTO genotype is associated with phenotypic variability of body mass index
    Jian Yang
    University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    Nature 490:267-72. 2012
    ..of genome-wide association studies of phenotypic variation using ∼170,000 samples on height and body mass index (BMI) in human populations...
  30. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..We analyzed the plasma adiponectin concentrations in age- and body mass index (BMI)-matched nondiabetic and type 2 diabetic subjects with and without coronary artery disease (CAD)...
  31. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
    ....
  32. ncbi Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    N Engl J Med 351:2683-93. 2004
    ..Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown...
  33. ncbi The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)
    Rachel P Wildman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Room 1309, Bronx, NY 10461, USA
    Arch Intern Med 168:1617-24. 2008
    ....
  34. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  35. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  36. ncbi Effects of bariatric surgery on mortality in Swedish obese subjects
    Lars Sjöström
    Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    N Engl J Med 357:741-52. 2007
    ..In fact, many observational studies suggest that weight reduction is associated with increased mortality...
  37. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  38. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  39. pmc Childhood body-mass index and the risk of coronary heart disease in adulthood
    Jennifer L Baker
    Institute of Preventive Medicine, Center for Health and Society, Copenhagen, Denmark
    N Engl J Med 357:2329-37. 2007
    ..Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the long-term effects of excess childhood weight on CHD, however, remains unknown...
  40. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002
    ..There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables...
  41. ncbi Waist circumference and not body mass index explains obesity-related health risk
    Ian Janssen
    Department of Community Health and Epidemiology, Queen s University, Kingston, Canada
    Am J Clin Nutr 79:379-84. 2004
    The addition of waist circumference (WC) to body mass index (BMI; in kg/m(2)) predicts a greater variance in health risk than does BMI alone; however, whether the reverse is true is not known.
  42. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans...
  43. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
    ..Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors...
  44. ncbi Genetics of gene expression and its effect on disease
    Valur Emilsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:423-8. 2008
    ..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
  45. ncbi Childhood adiposity, adult adiposity, and cardiovascular risk factors
    Markus Juonala
    Research Center of Applied and Preventive Cardiovascular Medicine Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
    N Engl J Med 365:1876-85. 2011
    ..Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults...
  46. pmc Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study
    Gillian K Reeves
    Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF
    BMJ 335:1134. 2007
    To examine the relation between body mass index (kg/m2) and cancer incidence and mortality.
  47. pmc Increase in prevalence of overweight in Dutch children and adolescents: a comparison of nationwide growth studies in 1980, 1997 and 2009
    Yvonne Schönbeck
    TNO Child Health, Leiden, The Netherlands
    PLoS ONE 6:e27608. 2011
    To assess the prevalence of overweight and obesity among Dutch children and adolescents, to examine the 30-years trend, and to create new body mass index reference charts.
  48. pmc Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study
    Hagit Hochner
    Hebrew University Hadassah, Braun School of Public Health, Jerusalem, Israel
    Circulation 125:1381-9. 2012
    Accumulating evidence demonstrates that both maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity...
  49. ncbi Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994
    Stephen Cook
    Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Arch Pediatr Adolesc Med 157:821-7. 2003
    ..In adults the metabolic syndrome imposes a substantial risk for type 2 diabetes mellitus and premature coronary heart disease. Even so, no national estimate is currently available of the prevalence of this syndrome in adolescents...
  50. ncbi A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0·5 could be a suitable global boundary value
    Lucy M Browning
    Ashwell Associates Ltd, Ashwell Street, Ashwell, Hertfordshire SG7 5PZ, UK
    Nutr Res Rev 23:247-69. 2010
    ....
  51. ncbi Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults
    Bei fan Zhou
    Institute of Cardiovascular Disease, Chinese Academy of Medical Sciences
    Biomed Environ Sci 15:83-96. 2002
    ..g., high diabetes, diabetes mellitus, and lipoprotein disorders)...
  52. pmc Meta-analysis identifies common variants associated with body mass index in east Asians
    Wanqing Wen
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 44:307-11. 2012
    Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry...
  53. ncbi Obesity and the metabolic syndrome in developing countries
    Anoop Misra
    Department of Diabetes and Metabolic Diseases, Fortis Flt Lt Rajan Dhall Hospital, Vasant Kunj, New Delhi 110070, India
    J Clin Endocrinol Metab 93:S9-30. 2008
    ..Prevalence of obesity and the metabolic syndrome is rapidly increasing in developing countries, leading to increased morbidity and mortality due to type 2 diabetes mellitus (T2DM) and cardiovascular disease...
  54. ncbi Using pedometers to increase physical activity and improve health: a systematic review
    Dena M Bravata
    Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA
    JAMA 298:2296-304. 2007
    ..Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity...
  55. ncbi Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus
    Charlotte M Boney
    Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Brown Medical School and Hasbro Children s Hospital, Providence, Rhode Island, USA
    Pediatrics 115:e290-6. 2005
    ..We examined the development of MS among large-for-gestational-age (LGA) and appropriate-for-gestational age (AGA) children...
  56. pmc The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994
    Yong Woo Park
    Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Arch Intern Med 163:427-36. 2003
    ..The extent to which the metabolic syndrome is associated with demographic and potentially modifiable lifestyle factors in the US population is unknown...
  57. ncbi Elevated C-reactive protein levels in overweight and obese adults
    M Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    JAMA 282:2131-5. 1999
    ..Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat...
  58. ncbi Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    Ian Janssen
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    J Am Geriatr Soc 50:889-96. 2002
    ..To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons...
  59. ncbi Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  60. pmc The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    PLoS Med 9:e1001212. 2012
    Adiposity, assessed as elevated body mass index (BMI), is associated with increased risk of ischemic heart disease (IHD); however, whether this is causal is unknown...
  61. pmc Meta-analysis of short sleep duration and obesity in children and adults
    Francesco P Cappuccio
    Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, UK
    Sleep 31:619-26. 2008
    ..Recent epidemiological studies suggest that short sleep duration may be associated with the development of obesity from childhood to adulthood...
  62. ncbi Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
    ..The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease...
  63. ncbi Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    Sarah Lewington
    CTSU, University of Oxford, Oxford OX3 7LF, UK
    Lancet 370:1829-39. 2007
    ..This meta-analysis combined prospective studies of vascular mortality that recorded both blood pressure and total cholesterol at baseline, to determine the joint relevance of these two risk factors...
  64. ncbi Dynamics of fat cell turnover in humans
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nature 453:783-7. 2008
    ..Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index. Neither adipocyte death nor generation rate is altered in early onset obesity, suggesting a tight regulation ..
  65. ncbi Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study
    David S Freedman
    Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Pediatr 150:12-17.e2. 2007
    To explore the accuracy of various body mass index (BMI) cutpoints in identifying children who have excess adiposity (based on skinfold thicknesses), adverse levels of lipids, insulin, and blood pressures, and a high risk for severe ..
  66. ncbi Impact of overweight on the risk of developing common chronic diseases during a 10-year period
    A E Field
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1581-6. 2001
    ..Overweight adults are at an increased risk of developing numerous chronic diseases...
  67. pmc A better index of body adiposity
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 19:1083-9. 2011
    ..It can be used in the clinical setting even in remote locations with very limited access to reliable scales. The BAI estimates %adiposity directly...
  68. pmc Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 42:142-8. 2010
    ..Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18))...
  69. pmc Childhood obesity, other cardiovascular risk factors, and premature death
    Paul W Franks
    Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    N Engl J Med 362:485-93. 2010
    ..The effect of childhood risk factors for cardiovascular disease on adult mortality is poorly understood...
  70. ncbi The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity
    Maria Hagstromer
    Unit for Preventive Nutrition Novum, Department of Biosciences, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Public Health Nutr 9:755-62. 2006
    ..The short version of the IPAQ has been tested extensively and is now used in many international studies. The present study aimed to explore the validity characteristics of the long-version IPAQ...
  71. pmc Association between body-mass index and risk of death in more than 1 million Asians
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    N Engl J Med 364:719-29. 2011
    ..Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin...
  72. pmc Human gut microbiota in obesity and after gastric bypass
    Husen Zhang
    Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Proc Natl Acad Sci U S A 106:2365-70. 2009
    ..The large bacterial population shift seen in the post-gastric-bypass individuals may reflect the double impact of the gut alteration caused by the surgical procedure and the consequent changes in food ingestion and digestion...
  73. pmc The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:402-8. 2011
    ..Sex differences, and in some instances race differences, in the relationships between anthropometry and fat-specific depots demonstrate that these characteristics need to be considered when predicting adiposity from WC or BMI...
  74. pmc Body mass index, waist circumference and waist-hip ratio: which is the better discriminator of cardiovascular disease mortality risk?: evidence from an individual-participant meta-analysis of 82 864 participants from nine cohort studies
    S Czernichow
    Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France
    Obes Rev 12:680-7. 2011
    ..b>Body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were measured directly...
  75. pmc Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    Tuomas O Kilpeläinen
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Nat Genet 43:753-60. 2011
    Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2...
  76. ncbi The epidemiology of obesity
    Cynthia L Ogden
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA
    Gastroenterology 132:2087-102. 2007
    ..Among adults, obesity is defined as a body mass index of 30 or greater...
  77. ncbi Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    Youfa Wang
    Department of Human Nutrition and Division of Epidemiology and Biostatistics, University of Illinois at Chicago, USA
    Am J Clin Nutr 81:555-63. 2005
    ..However, few studies have compared the predictive power of overall obesity with that of central obesity. The cutoffs for waist circumference (WC) and waist-to-hip ratio (WHR) as measures of abdominal adiposity remain controversial...
  78. ncbi Cause-specific excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 298:2028-37. 2007
    The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population.
  79. pmc Life course variations in the associations between FTO and MC4R gene variants and body size
    Rebecca Hardy
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
    Hum Mol Genet 19:545-52. 2010
    The timing of associations between common genetic variants for weight or body mass index (BMI) across the life course may provide insights into the aetiology of obesity...
  80. pmc Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort study
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol BS8 2BN, UK
    BMJ 341:c6224. 2010
    To examine the prospective associations between body mass index (BMI), waist circumference, and fat mass in childhood and cardiovascular risk factors at age 15-16.
  81. pmc A multicenter, randomized trial of treatment for mild gestational diabetes
    Mark B Landon
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, USA
    N Engl J Med 361:1339-48. 2009
    ..It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes...
  82. ncbi Identifying risk for obesity in early childhood
    Philip R Nader
    Division of Community Pediatrics, University of California, San Diego, California, USA
    Pediatrics 118:e594-601. 2006
    ..Our aim with this study was to assist clinicians by estimating the predictive value of earlier levels of BMI status on later risk of overweight and obesity during the middle childhood and early adolescent years...
  83. ncbi Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis
    Crystal Man Ying Lee
    Nutrition and Lifestyle Division, The George Institute for International Health, University of Sydney, PO Box M 201, Missenden Road, Sydney NSW 2050, Australia
    J Clin Epidemiol 61:646-53. 2008
    ..To determine which simple index of overweight and obesity is the best discriminator of cardiovascular risk factors...
  84. ncbi Genetic and environmental factors in relative body weight and human adiposity
    H H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
    Behav Genet 27:325-51. 1997
    We review the literature on the familial resemblance of body mass index (BMI) and other adiposity measures and find strikingly convergent results for a variety of relationships...
  85. pmc A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
    R G Walters
    Section of Genomic Medicine, Imperial College London, London W12 0NN, UK
    Nature 463:671-5. 2010
    ..7% of our morbid obesity cases (body mass index (BMI) >or= 40 kg m(-2) or BMI standard deviation score >or= 4; P = 6.4 x 10(-8), odds ratio 43...
  86. pmc Proximity to food establishments and body mass index in the Framingham Heart Study offspring cohort over 30 years
    Jason P Block
    Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, 133 Brookline Avenue, Boston, MA 02215, USA
    Am J Epidemiol 174:1108-14. 2011
    Existing evidence linking residential proximity to food establishments with body mass index (BMI; weight (kg)/height (m)(2)) has been inconclusive...
  87. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  88. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005
    ..S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP)...
  89. pmc Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..These changes could have a significant impact on the risk of obesity-related morbidity in the general population...
  90. pmc Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients
    Fabrice Armougom
    URMITE UMR CNRS 6236, IRD 3R198, Universite de la Mediterranee, Faculte de Medecine, and Nutrition and Diabetology Department, University Hospital Sainte Marguerite, Marseille, France
    PLoS ONE 4:e7125. 2009
    ..The roles of the archaeon Methanobrevibacter smithii and Lactobacillus species have not been described in these studies...
  91. ncbi Health-related quality of life of severely obese children and adolescents
    Jeffrey B Schwimmer
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, School of Medicine, University of California, San Diego 92103, USA
    JAMA 289:1813-9. 2003
    ..One in 7 US children and adolescents is obese, yet little is known about their health-related quality of life (QOL)...
  92. ncbi Updated definitions of healthy ranges for serum alanine aminotransferase levels
    Daniele Prati
    Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
    Ann Intern Med 137:1-10. 2002
    ..Current standards for "normal" ALT level were defined by using populations that included persons with subclinical liver disease...
  93. ncbi Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
  94. ncbi Decreased plasma adiponectin concentrations in women with dyslipidemia
    Miyao Matsubara
    Division of Endocrinology and Metabolism, Internal Medicine, Otaru City General Hospital, Wakamutsu 1 2 1, Otaru 047 8550, Japan
    J Clin Endocrinol Metab 87:2764-9. 2002
    ..and apolipoprotein (apo) levels in 352 nondiabetic women, 16-86 yr old, with a wide range of body weight [body mass index (BMI), 14.8-36.3 kg/m(2)]. Plasma adiponectin concentrations in women with the highest tertile of TG (1...
  95. ncbi Long-term weight loss maintenance
    Rena R Wing
    Brown Medical School, The Miriam Hospital, Department of Psychiatry, Providence, RI, USA
    Am J Clin Nutr 82:222S-225S. 2005
    ..National Weight Control Registry members provide evidence that long-term weight loss maintenance is possible and help identify the specific approaches associated with long-term success...
  96. ncbi Reducing children's television viewing to prevent obesity: a randomized controlled trial
    T N Robinson
    Department of Pediatrics, Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
    JAMA 282:1561-7. 1999
    ..Some observational studies have found an association between television viewing and child and adolescent adiposity...
  97. ncbi Validity of self-reported height and weight in 4808 EPIC-Oxford participants
    Elizabeth A Spencer
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, Gibson Building, The Radcliffe Infirmary, UK
    Public Health Nutr 5:561-5. 2002
    ..weight by comparison with measured height and weight in a sample of middle-aged men and women, and to determine the extent of misclassification of body mass index (BMI) arising from differences between self-reported and measured values.
  98. pmc Gene X environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
    Jeanne M McCaffery
    Weight Control and Diabetes Research Center, Brown Medical School and The Miriam Hospital, Providence, RI 02903, USA
    Am J Clin Nutr 89:1011-8. 2009
    Secular trends over the past several decades suggest an environmental influence on body mass index (BMI)...
  99. ncbi Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype
    Sofia Inez Iqbal Kring
    Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
    Obes Facts 1:138-45. 2008
    ..In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candidate gene polymorphisms in these ten genes in the same cohort...
  100. ncbi Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials
    Seamus P Whelton
    Tulane University, New Orleans, Louisiana 70112, USA
    Ann Intern Med 136:493-503. 2002
    ..This meta-analysis of randomized, controlled trials was conducted to determine the effect of aerobic exercise on blood pressure...
  101. ncbi Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults
    M Dalton
    International Diabetes Institute, Melbourne, Caulfield, Victoria, Australia
    J Intern Med 254:555-63. 2003
    To compare body mass index (BMI), waist circumference and waist-hip ratio (WHR) as indices of obesity and assess the respective associations with type 2 diabetes, hypertension and dyslipidaemia.

Research Grants74

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..test tagSNPs in each of these candidate eCB/CB1 signaling genes for association with 12 quantitative traits: body mass index (BMI), waist circumference, hip circumference, waist/hip ratio (WHR), fasting glucose, insulin, insulin/..
  2. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..between OSA and insulin resistance, glucose intolerance and the risk of diabetes, independently of body mass index. In an analysis of over 2500 non- diabetic individuals, the presence of OSA was associated with a ..
  3. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..One in five women who deliver in the United States is obese (body mass index (BMI) of >30 kg/m2)...
  4. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..One in five women who deliver in the United States is obese (body mass index (BMI) of >30 kg/m2)...
  5. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..Furthermore, changes in body fat observed in obesity, or changes in body mass index (as observed in patients suffering from functional gastrointestinal disorders) have been associated with ..
  6. Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family Study
    Ana Navas-Acien; Fiscal Year: 2013
    ..and medical information and measures of fasting glucose and insulin, lipid profile, hypertension endpoints, body mass index, and waist and hip circumferences are available at baseline and follow-up visits through 2011...
  7. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..Secondary outcomes are changes in percent body fat, body mass index, waist-to-hip ratio, fasting glucose, blood pressure, plasma lipids, activity, and diet...
  8. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..In addition, given the association of early life stress, increased body mass index, treatment resistance and dysregulated sleep with inflammation, these factors will also be examined...
  9. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..in Lusaka, Zambia (CIDRZ) and who exhibit high risk for early ART mortality (CD4+ count <50 cells/<L or body mass index [BMI] <16 kg/m2)...
  10. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..be harmful for older adults-weight loss can decrease lean muscle mass and bone mineral density, and higher body mass index has been associated with lower mortality in older adults...
  11. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..Current methods for assessing obesity focus on either nonspecific measures of overall body weight (i.e. body mass index) or the extent of abdominal ("central") adiposity...
  12. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..g., menopausal status, body mass index, physical activity, postmenopausal hormone use, alcohol intake, and other plasma obesity- related markers), ..
  13. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..and 2 hr. glucose and insulin sensitivity) determined by an oral glucose tolerance test (OGTT) and body mass index (BMI) at the time of the OGTT...
  14. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..of atherosclerosis, diabetes, hypertension, and cardiovascular disease in this ethnic group, despite low body mass index. However, there are no longitudinal studies of South Asians to determine other risk factors that may explain ..
  15. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..In addition, observational studies show an inverse relationship between 25(OH) D levels and body mass index (BMI)...
  16. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ..Risk of NHL also has been associated with increased body mass index (BMI) and some autoimmune conditions with each in turn associated with levels and circulation of sex- ..
  17. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging. ..
  18. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..e. body mass index. The overall hypothesis of this proposal is that PRCP is a risk factor for hypertension and/or MI and stroke ..
  19. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..studies have revealed a dose-dependant relationship between reduced sleep duration and increased body mass index (BMI)...
  20. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..T) deficiency, and preliminary data indicates that physiologic replacement leads to an increase in body mass index (BMI). Studies in animals and humans implicate T in feeding behavior...
  21. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..More than 1/3 of women in the U.S. are now starting their pregnancies with a body mass index or 30 or greater, a condition that was unusual to rare 50 years ago...
  22. Predictors of tuberculosis by stage of insulin resistance
    Alicia Hsin Ming Chang; Fiscal Year: 2013
    ..dyslipidemia, insulin levels, and systemic inflammation) and co- morbidity profiles (duration of diabetes, body mass index, microalbuminuria, smoking, etc.) in insulin resistant diabetes affect risk of tuberculosis. 3...
  23. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..Serum lipids, fasting serum glucose, body mass index and waist circumference were also measured every 3 years over the same time period...
  24. Can diet- &exercise-induced weight loss improve asthma control in obese adults?
    Jun Ma; Fiscal Year: 2013
    ..We will randomize 324 patients ages 18-70 years who have suboptimally controlled, persistent asthma and a body mass index of 30.0 to 39...
  25. The Effect of Behavioral and Physiological Factors on Obesity Risk in Children
    Karen B Dorsey; Fiscal Year: 2012
    ..Study participants will be non-obese 7 - to 9- year old children with a body mass index above the 50th percentile for age and gender in order to identify early clinical indicators of increased risk ..
  26. An internet based prospective study of time to pregnancy
    Elizabeth E Hatch; Fiscal Year: 2013
    ..questionnaires that collect data on a wide range of factors including alcohol consumption, caffeine intake, body mass index, physical activity and sedentary behavior...
  27. DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASE
    Frank B Hu; Fiscal Year: 2013
    ..We hypothesize that the inverse association between diet quality and body mass index (BMI) is at least partially explained by lower energy intake...
  28. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..This study will explore and contrast changes in body mass index (BMI) observed over the 10-week study period in the intervention vs...
  29. Cardiometabolic Risk Factors and Obesity in Adolescents with Down Syndrome
    Sheela Natesh Magge; Fiscal Year: 2013
    ..Aims: 1) To compare the relationship between body mass index and adiposity (measured by DXA), and cardiometabolic risk factors (non-HDL cholesterol, lipoprotein subclass ..
  30. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012
    ..g., body mass index/weight, waist-to-hip ratio, height) and 4) relevant disease-associated biomarkers (e.g...
  31. Growth and Cardiometabolic Risk Among In Utero Drug Exposed Children
    SARAH ELIZABETH MESSIAH; Fiscal Year: 2013
    ..research has three specific aims: (1) To longitudinally compare anthropometric measures (height, weight, body mass index, waist circumference, and body composition) among urban, African American children and adolescents who were ..
  32. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..Recent research has revealed that inflammation-infection and higher body mass index (BMI) are the main predictors of LE besides treatment-related risk...
  33. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ..PPI-non users frequency matched with the PPI users on race, age, sex and body mass index. The pQCT measurements will be obtained at baseline and then yearly over the next 3 years...
  34. Weight gain, type 2 diabetes, and factors that affect neuroendocrine function
    EDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2013
    ..We have already published on the relation of body mass index, dietary factors, and physical activity to risk of T2D and have also reported positive associations of racism ..
  35. Impact of adipokines and insulin resistance on progression of prehypertension
    Cynthia Cheng; Fiscal Year: 2013
    ..At baseline and at follow-up (1.5-2 years after enrollment x 2 visits), we will assess obesity (body mass index, BMI, waist circumference, WC, abdominal skinfold thickness, AST), adipokine levels (IL-6, TNF1, PAI-1, ..
  36. Population-Based Reference Ranges for Estradiol and Estrone in Men
    VASAN S RAMACHANDRAN; Fiscal Year: 2013
    ..cardiovascular disease, bone mineral density, physical function, and sexual symptoms, adjusting for age, body mass index, waist circumference, blood pressure, smoking, lipids, glucose, diet and physical activity...
  37. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..and dietary patterns remain critical factors for modulating long term weight control of obese individuals (body mass index, BMI >30), but surgical interventions are often needed to treat morbid obesity (clinically severe, BMI >..
  38. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..acuity, contrast sensitivity, ultrasonic corneal pachymetry of central corneal thickness, height, weight, body mass index, blood pressure, heart rate, medical history, visual field testing (using standard automated perimetry), ..
  39. Sugar-sweetened beverage taxes, beverage purchasing patterns, and weight
    Jamie F Chriqui; Fiscal Year: 2013
    ..vitamin and nutrient intake, reductions in consumption of healthier beverages such as milk, and increased body mass index (BMI), risk of obesity and diabetes...
  40. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2013
    ..We will recruit 80 patients with severe OSA and morbid obesity (body mass index, BMI, of 35-40 kg/m2) from two large clinical sleep programs that together care for a wide spectrum and ..
  41. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..a) baseline and follow up blood levels of these nutrients, (b) gender, (c) race/skin pigmentation, and (d) body mass index? Tertiary Aims: In the VITAL cohort, will Vitamin D3 and/or EPA+DHA supplementation a) reduce the risk of ..
  42. Genetic Instability &Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2012
    ..profiles will be obtained by personal interview on smoking history, alcohol consumption, dietary intake, body mass index (BMI), physical activity, cancer family history, occupational exposures, previous medical history, and ..
  43. Research and Mentoring on Energetic Factors and Cancer: Established Investigator
    Leslie Bernstein; Fiscal Year: 2013
    ..body size (using height, weight, waist and hip measurements, independently, and various ratio measures like body mass index, waist-hip ratio, and waist-height ratio) and risk of breast, endometrial, ovarian, lung, colon, pancreas, ..
  44. Enhancing NEAT to Treat Obesity
    Catherine M Kotz; Fiscal Year: 2012
    ..as they project to brain areas involved in arousal and activity and loss of brain orexin activity increases body mass index. Sensitivity to orexin A (OxA) SPA promotion is inherent to OR rats and may be critically important in ..
  45. Neuroanatomical and functional outcomes of pediatric obstructive sleep apnea
    Robert Joseph Thomas; Fiscal Year: 2012
    ..We will assess differences from healthy age, body mass index, gender, and Tanner stage matched controls, pre and 6-months post treatment (tonsillectomy or positive airway ..
  46. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2013
    ..b>Body mass index and bioelectric impedence analysis will be used to assess body mass index and adiposity, respectively...
  47. Modifiable lifestyle-related factors and triple negative breast cancer prognosis
    SARAH JEAN NECHUTA; Fiscal Year: 2013
    ..To investigate this hypothesis, we propose to evaluate the associations of post-diagnosis body mass index, weight change, post-diagnosis recreational physical activity, and select dietary factors suggested to be ..
  48. Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVD
    Anoop Shankar; Fiscal Year: 2012
    ..physical examination, and laboratory data on potential confounding factors such as smoking, alcohol intake, body mass index (BMI), blood pressure, fasting glucose, serum lipids, high sensitivity C-reactive protein, and several other ..
  49. Epidemiologic Study of Sick Sinus Syndrome
    Alvaro Alonso; Fiscal Year: 2012
    ..studied include, but are not limited to, socioeconomic variables, smoking, physical activity, diet, smoking, body mass index and other adiposity measures, blood pressure, diabetes, blood cholesterol, electrocardiographic parameters, ..
  50. Is HIV-associated lipodystrophy a risk factor for cirrhosis of the liver?
    George Ioannou; Fiscal Year: 2013
    ..whether there are other important modifiers of the association between HALS and cirrhosis, including body mass index, race-ethnicity, and diabetes...
  51. Endogenous G-Protein Coupled Receptor Antagonists
    Carrie Haskell-Luevano; Fiscal Year: 2012
    ..Obesity (body mass index >25) afflicts millions of people in the United States and other countries, and is a major risk factor for ..
  52. Prognostic markers in metastatic melanoma
    BONNIE ELYSSA GOULDROTHBERG; Fiscal Year: 2013
    ..This proposal also plans to evaluate the association of lifestyle choices such as body mass index, and tobacco and alcohol use with survival in this population...
  53. Catalytic Antibody-Based Vaccine For Weight Loss
    AMANDA LEE GARNER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Nearly 1 billion people worldwide are overweight or obese (body mass index, BMI, = 25-<30 and >30 kg/m2, respectively)...
  54. Epidemiologic Studies of Type 2 Diabetes in Normal Weight Adults
    MERCEDES RENEE CARNETHON; Fiscal Year: 2010
    ..g., type 2 diabetes [T2DM], hypertriglyceridemia, hypertension) in persons with normal body mass index (BMI)...
  55. Biopsychosocial approaches to healthy aging
    Terrie Vasilopoulos; Fiscal Year: 2012
    ..Physical function measures include blood pressure, body mass index, and medication...
  56. Changes in neural response to eating after bariatric surgery: MRI results
    Thomas A Wadden; Fiscal Year: 2013
    ..e., body mass index = 40 kg/m2)...
  57. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..with clinical markers as outcomes, we will determine the impact of pubertal factors, obesity-related factors (body mass index, serum leptin levels, genotypes for leptin and leptin receptor), and environmental risk factors (including, ..
  58. Role of thermoregulatory leptin action via the DMH in body weight control
    KAVON PAUL REZAI-ZADEH; Fiscal Year: 2013
    ..Having a body mass index (BMI) >30 kg/m2 clinically defines an individual as obese and significantly increases that individual'..
  59. Outcomes of Community Naturopathic Medical Care for Type 2 Diabetes
    Daniel C Cherkin; Fiscal Year: 2010
    ..Changes in HbA1c (primary outcome) and in body mass index, lipids, blood pressure and triglycerides over the one year treatment period will be measured...
  60. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..births, miscarriages and fetal deaths, intra-uterine growth retardation, preterm delivery, smoking, alcohol, body mass index, diabetes, use of anti-depressants, and sub-fertility...
  61. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Robert S Sandler; Fiscal Year: 2013
    ..the association between adherent bacteria profiles and diet/lifestyle such as fiber, meat intake, obesity (body mass index (BMI), waist-hip-ratio), and NSAID use in relation to colorectal adenomas...
  62. Telomere Attrition Rate and Periodontitis: a nested case control study in the ARI
    ANNE ELIZABETH SANDERS; Fiscal Year: 2013
    ..variables are established risk and protective indicators for periodontitis including smoking, diabetes, body mass index, diet, physical activity, systemic inflammation and oxidative stress...
  63. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..The prevalence of type 2 diabetes has conservatively tripled in the last 30 years. Individuals with a body mass index (BMI) of 30 or more have a 5-fold greater risk of diabetes compared to subjects with BMI of 25 or less...
  64. EPIDEMIC HYPERTENSION IN NIGERIAN WORKERS
    Clareann Bunker; Fiscal Year: 1999
    ..Smaller differences were observed by staff status in females. Mean body mass index (BMI) was very low in the males (22.9 in Senior and 21.4 in Junior staff) and low in females (25...
  65. An analysis of environmental risk factors for obesity
    Walker Poston; Fiscal Year: 2007
    ..In the proposed study, we will collect both individual-level health data including weight and body mass index (BMI), status on other health conditions and behaviors, as well information on the density of social ..
  66. Economic Contextual Influences on Population Diet and Obesity
    Lisa Powell; Fiscal Year: 2010
    ..and chips), beverage (soda) and restaurant state sales taxes and food consumption patterns, diet quality, body mass index (BMI) and obesity prevalence among children, adolescents, and adults...
  67. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..of age, women postmenopausal and less than 65) with LDL C values greater than or equal to 130 mg/dI and a body mass index greater than or equal to 28 and less than 38 kg/m2...
  68. HYPOTHALAMIC CONTROL OF FEEDING AND METABOLISM
    ROGER CONE; Fiscal Year: 2003
    ..Obesity, as defined by a body mass index above 25, increased from an incidence of 24% in 1980 to 33% in 1990 in a large representative sample in the ..
  69. Novel Anti-Obesity Drugs Targeting Fat Processing Pathway
    Henry Pelish; Fiscal Year: 2009
    ..The FDA-approved lipase inhibitor Orlistat prevents fat processing in the gut, leading to reduced body mass index in obese patients. The unprocessed fats are not absorbed by the body and pass through the digestive tract...
  70. Primary Prevention of Weight Gain for Women Aged 25-45
    Walter Willett; Fiscal Year: 2004
    ..Overweight (BMI (Body Mass Index) 25.0-29...
  71. Aminosterol MSI-1436 as a Therapeutic for Obesity
    Michael McLane; Fiscal Year: 2004
    ..Today, 64.5 percent of adult Americans (about 127 million) are categorized as being overweight (body mass index >25) or obese (body mass index >30)...
  72. MOLECULAR MECHANISMS AND MODULATION OF GLIAL ACTIVATION
    Linda Van Eldik; Fiscal Year: 2009
    ..The proportion of children exceeding the 95lh and 85vhpercentiles for body mass index (BMI) is among the greatest in Mexican-Americans...
  73. Technology to Improve Assessment of Physical Activity
    John Jakicic; Fiscal Year: 2005
    ..body size impact the accuracy of the KAL-X Sensor, we will recruit equal numbers of men and women from three body mass index categories (20-24.9 kg/m 2, 25-29.9 kg/m 2, 30-35 kg/m2)...
  74. Neural Mechanisms of Overeating in Prader-Willi Syndrome
    Anastasia Dimitropoulos; Fiscal Year: 2009
    ..caloric value during fasting and post-meal states in individuals with PWS and individuals matched to PWS on body mass index, age, and gender, and (2) to determine the relation between this neural activity and body mass index, food ..