Genomes and Genes
Summary: The use of animals as investigational subjects.
Publications252 found, 100 shown here
- Should IACUCs review scientific merit of animal research projects?Michael D Mann
IACUC, Nebraska Medical Center, Omaha, 68198 7830, USA
Lab Anim (NY) 33:26-31. 2004..The authors examine this issue, discuss the pros and cons, suggest how IACUCs can go about reviewing protocols for scientific merit, and question what effect recent changes in regulations will have on this issue...
- Comments on the sixth report of the Animal Welfare Advisory CommitteeSylvia Vaughan
FRAME, Russell and Burch House, 96 98 North Sherwood Street, Nottingham NG1 4EE, UK
Altern Lab Anim 31:207-12. 2003....
- Ahimsa and alternatives -- the concept of the 4th R. The CPCSEA in IndiaShiranee Pereira
Committee for the Purpose of Control and Supervision of Experiments on Animals, IN Chennai
ALTEX 22:3-6. 2005..This paper is about the Indian law on animal experimentation and the success story of the CPCSEA in India in inculcating the credo of 4Rs -- Replacement, Reduction, ..
- Punctual professor using passé procedures. Contrary to the 3 RsPierre Freeman
IACUC, IBC and Research Compliance and Training Officer, North Dakota State University, Fargo, ND, USA
Lab Anim (NY) 35:18. 2006
- Making sense of multiple protocols and grant applications. Taking protocols for grantedTorsten A Hopp
Baylor College of Medicine, Houston, TX, USA
Lab Anim (NY) 35:16. 2006
- A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasibleCarlijn R Hooijmans
Radboud University Nijmegen Medical Centre, Central Animal Laboratory and 3R Research Centre, Geert Grooteplein Noord 29, route 231, 6525 EZ Nijmegen, The Netherlands
Altern Lab Anim 38:167-82. 2010..However, they are not yet widely used nor undertaken in the field of animal experimentation, even though there is a lot to be gained from the process...
- Where is the evidence that animal research benefits humans?Pandora Pound
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 328:514-7. 2004
- Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMedCarlijn R Hooijmans
Radboud University Nijmegen Medical Centre, Central Animal Laboratory and 3R Research Centre, Geert Grooteplein Noord 29, route 231, Nijmegen, The Netherlands
Lab Anim 44:170-5. 2010..SRs in laboratory animal science is the fact that searching for all available literature concerning animal experimentation is rather difficult...
- Animal experimentation in snake venom research and in vitro alternativesPaula G Sells
Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Toxicon 42:115-33. 2003..In the meantime, the principles of Reduce, Refine and Replace relating to animals in research are increasingly endorsed by those working in the field and the many agencies regulating ethical and research policy...
- How to become a top model: impact of animal experimentation on human Salmonella disease researchRenee M Tsolis
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95661 8645, USA
Infect Immun 79:1806-14. 2011..This article reviews important milestones in the use of animal models to study human Salmonella disease and identify research needs to guide future work...
- Systematic reviews and meta-analyses of preclinical studies: publication bias in laboratory animal experimentsD A Korevaar
Department of General Practice, Academic Medical Center AMC, University of Amsterdam UvA, PO Box 22700, 1100 DD Amsterdam, The Netherlands
Lab Anim 45:225-30. 2011..A statistically significant proportion of MAs considered publication bias (26/35) and tried to formally assess it (21/35)...
- Emergency medicine animal research: does use of randomization and blinding affect the results?Vik Bebarta
University of Colorado Health Sciences Center, Denver 80262, USA
Acad Emerg Med 10:684-7. 2003....
- A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reportingJaime L Peters
Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, UK
J Environ Sci Health B 41:1245-58. 2006..Further consideration of the use and methodological quality and reporting of such studies is needed...
- The current status of animal use and alternatives in Korean veterinary medical schoolsGwi Hyang Lee
The Institute for the 3Rs, College of Veterinary Medicine, Konkuk University, Seoul, Korea
Altern Lab Anim 38:221-30. 2010..The information presented represents the first such data gathered in Korea, which should prove useful for monitoring the implementation of replacement, reduction, and refinement measures in animal use for education purposes...
- Publication bias in laboratory animal research: a survey on magnitude, drivers, consequences and potential solutionsGerben Ter Riet
Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 7:e43404. 2012..Publication bias jeopardizes evidence-based medicine, mainly through biased literature syntheses. Publication bias may also affect laboratory animal research, but evidence is scarce...
- Methodological quality of systematic reviews of animal studies: a survey of reviews of basic researchLuciano E Mignini
Centro Rosarino de Estudios Perinatales, Rosario, Argentina
BMC Med Res Methodol 6:10. 2006..Systematic reviews can serve as a tool in translation of basic life sciences research from laboratory to human research and healthcare. The extent to which reviews of animal research are systematic and unbiased is not known...
- Assessing the search for and implementation of the Three Rs: a survey among scientistsMarlies Leenaars
Radboud University Nijmegen Medical Centre, Central Animal Laboratory, Nijmegen, The Netherlands
Altern Lab Anim 37:297-303. 2009....
- Progress in animal experimentation ethics: a case study from a Brazilian medical school and from the international medical literatureEdvaldo Luiz Ramalli Jr
Faculty of Medicine of Ribeirao Preto, USP, Sao Paulo, Brazil
Acta Cir Bras 27:659-63. 2012..This study describes in Brazil and in the global biomedical community the time course of the development of animal research welfare guidelines...
- Reducing animal experimentation in foot-and-mouth disease vaccine potency testsRichard Reeve
Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
Vaccine 29:5467-73. 2011....
- Factors influencing the effectiveness of research ethics committeesC A Schuppli
Animal Welfare Program, University of British Columbia, 2357 Main Hall, Vancouver, British Columbia, V6T 1Z4, Canada
J Med Ethics 33:294-301. 2007..These results, together with results from the literature on research ethics committees, suggested potential ways to improve the effectiveness of research ethics committees...
- The great primate debateSally Goodman
Nature 417:684-7. 2002
- [Alternatives to animal experimentation v.s. animal rights terrorism]Tsutomu Miki Kurosawa
The Institue of Experimental Animal Sciences, Osaka University Medical School, Suita City, Japan
Yakugaku Zasshi 128:741-6. 2008Systematic modern animal experimentation was established by Bernard Claude who wrote "An Introduction to the Study of Experimental Medicine" in 1865...
- Refining animal models in fracture research: seeking consensus in optimising both animal welfare and scientific validity for appropriate biomedical useJorg A Auer
Equine Hospital, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
BMC Musculoskelet Disord 8:72. 2007....
- Alternatives to animal experimentation in biomedical educationFranz P Gruber
FFVFF, CH Zuerich
ALTEX 21:33-48. 2004..The global situation is probably worse with animals still being used in high school teaching in some countries such as the USA...
- Towards ethically improved animal experimentation in the study of animal reproductionD Blache
UWA Institute of Agriculture M082, The University of Western Australia, Crawley, WA, Australia
Reprod Domest Anim 43:8-14. 2008..The outcome is a better experimental design, on both ethical and scientific grounds...
- Adaptation to stress induced by restraining rats and mice in nose-only inhalation holdersSandy P Narciso
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
Inhal Toxicol 15:1133-43. 2003..Rats and mice restrained for 4 h/day every day showed a gradual decrease in heart rate and temperature over time. Full adaptation to restraint required 14 days of fixed-duration daily restraint...
- Potential for unintended consequences of environmental enrichment for laboratory animals and research resultsKathryn Bayne
AAALAC International, Hilo, HI, USA
ILAR J 46:129-39. 2005....
- Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitationIan Roberts
Cochrane Injuries Group, Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London WC1B 3DP
BMJ 324:474-6. 2002
- Why are so many epidemiology associations inflated or wrong? Does poorly conducted animal research suggest implausible hypotheses?Michael B Bracken
School of Public Health and Medicine, Yale University, New Haven, CT, USA
Ann Epidemiol 19:220-4. 2009....
- Different views on ethics: how animal ethics is situated in a committee cultureM Ideland
Malmo University, Sweden
J Med Ethics 35:258-61. 2009Research that includes non-human animal experimentation is fundamentally a dilemmatic enterprise. Humans use other animals in research to improve life for their own species. Ethical principles are established to deal with this dilemma...
- Are animal models predictive for humans?Niall Shanks
Americans for Medical Advancement, 2251 Refugio Rd Goleta, CA 93117, USA
Philos Ethics Humanit Med 4:2. 2009..This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics...
- Is the use of sentient animals in basic research justifiable?Ray Greek
Americans for Medical Advancement, Goleta, CA 93117, USA
Philos Ethics Humanit Med 5:14. 2010..We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities...
- Surveying the literature from animal experiments: systematic review and meta-analysis are important contributionsMalcolm R Macleod
BMJ 331:110. 2005
- Animal experiments under fire for poor designJim Giles
Nature 444:981. 2006
- Animal research ethics in Africa: an overviewAceme Nyika
African Malaria Network Trust AMANET, Dar es Salaam, Tanzania
Acta Trop 112:S48-52. 2009..globally that has led to the development of guidelines and in some instances national laws governing animal experimentation. Although there may not be empirical data on the existence or adequacy of national and/or institutional ..
- Biomedical research. The endangered lab chimpJon Cohen
Science 315:450-2. 2007
- The ethics of animal experimentationBernard A Foex
Manchester Royal Infirmary, Oxford Road Manchester, M13 9WL, UK
Emerg Med J 24:750-1. 2007
- Animal ethical evaluation: an observational study of Canadian IACUCsLise Houde
Departement de Psychologie, Universite du Quebec a Montreal, C P 8888 Succ C V, Montreal, QC, Canada, H3C 3P8
Ethics Behav 13:333-50. 2003..The results are discussed in relation to previous nonobservational research that identified potential pitfalls and bias in animal ethical evaluation...
- The '3Rs' model and the concept of alternatives in animal research: a questionnaire surveySimone Pollo
Dipartimento di Studi Filosofici e Epistemologici, Universita di Roma La Sapienza, Rome, Italy
Lab Anim (NY) 33:47-53. 2004..The authors used a questionnaire survey to determine how well-known experts judged issues related to the 3Rs...
- Animal experimentationRoman Kolar
Animal Welfare Academy Akademie für Tierschutz, German Animal Welfare Federation Deutscher Tierschutzbund, Spechtstr 1, 85579 Neubiberg, Germany
Sci Eng Ethics 12:111-22. 2006..Legislation of animal experimentation in modern societies is based on the supposition that this is ethically acceptable when certain more or ..
- Research ethics I: Responsible conduct of research (RCR)--historical and contemporary issues pertaining to human and animal experimentationJennifer Horner
College of Health Sciences and Professions, Ohio University, W380 Grover Center, Athens, OH 45701, USA
J Speech Lang Hear Res 54:S303-29. 2011..Ethics I, they present a historical overview of the evolution of RCR in the United States then examine the evolution of human and animal experimentation from the birth of scientific medicine through World War II to the present day.
- Animal studies. NIH to end chimp breeding for researchJon Cohen
Science 316:1265. 2007
- Expanding the three Rs to meet new challenges in humane animal experimentationCatherine A Schuppli
Animal Welfare Program, Faculty of Agricultural Sciences and W Maurice Young Centre for Applied Ethics, University of British Columbia, 227 6356 Agriculture Road, Vancouver, BC V6T 1Z2, Canada
Altern Lab Anim 32:525-32. 2004The Three Rs are the main principles used by Animal Ethics Committees in the governance of animal experimentation, but they appear not to cover some ethical issues that arise today...
- Is the argument from marginal cases obtuse?Daniel A Dombrowski
Seattle University, Seattle, WA 98122, USA
J Appl Philos 23:223-32. 2006..The purpose of the present article is to argue that, despite Anderson's and Diamond's nuanced and perceptive treatments of the argument from marginal cases, this argument is not obtuse in either sense of the term...
- Comparison of treatment effects between animal experiments and clinical trials: systematic reviewPablo Perel
Crash Trials Coordinating Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT
BMJ 334:197. 2007..To examine concordance between treatment effects in animal experiments and clinical trials. Study design Systematic review...
- Solutions for research chimpanzeesLinda Brent
Chimp Haven, Inc, 710 Spring St, 2nd Fl, Shreveport, LA, 71101, USA
Lab Anim (NY) 33:37-43. 2004..The author provides an overview of efforts to improve chimpanzee welfare, and describes a facility dedicated to providing lifelong care for these nonhuman primates following retirement from research...
- Ethics: views from IACUC membersLisa Houde
Departement de Psychologie, Universite du Quebec a Montreal, Canada
Altern Lab Anim 37:291-6. 2009..The study suggests that IACUC members should be provided with more up-to-date information on topics such as animal ethics and animal use in research...
- [Animal experiments in biomedical research. An evaluation of the clinical relevance of approved animal experimental projects]Toni Lindl
Institut für angewandte Zellkultur, D München
ALTEX 22:143-51. 2005..The implications of our findings may lead to demands concerning improvement of the licensing practice in Germany...
- The interpretation and application of the three Rs by animal ethics committee membersCatherine A Schuppli
The W Maurice Young Centre for Applied Ethics, The University of British Columbia, 227 6356 Agricultural Road, Vancouver, BC V6T 1Z2, Canada
Altern Lab Anim 33:487-500. 2005....
- Translating animal research into clinical benefitDaniel G Hackam
BMJ 334:163-4. 2007
- The refining influence of ethics committees on animal experimentation in SwedenJoakim Hagelin
Department of Physiology, Division of Comparative Medicine, Uppsala University, Box 572, SE 751 23 Uppsala, Sweden
Lab Anim 37:10-8. 2003..In order to have maximal influence on the refinement of scientific protocols it is important that the scientists in the committees are continuously updated on developments in laboratory animal science...
- Surveying the literature from animal experimentsRoger Lemon
BMJ 330:977-8. 2005
- The beginning of the end for chimpanzee experiments?Andrew Knight
Animal Consultants International, 91 Vanbrugh Court, Wincott St, London SE114NR, UK
Philos Ethics Humanit Med 3:16. 2008..It could even result in the first global moratorium on invasive research, for any non-human species, unless conducted in the best interests of the individual or species...
- Implications of experimental technique for analysis and interpretation of data from animal experiments: outliers and increased variability resulting from failure of intraperitoneal injection proceduresR Gaines Das
Division of Biostatistics, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK
Lab Anim 41:312-20. 2007..p. injection failure in the analysis and interpretation of laboratory animal experiments involving this technique...
- The ethics of animal research. Talking Point on the use of animals in scientific researchSimon Festing
Research Defence Society in London, UK
EMBO Rep 8:526-30. 2007
- Specification of laboratory animal use in scientific articles: current low detail in the journals' instructions for authors and some proposalsV Alfaro
Department of Physiology, Biology, University of Barcelona, Barcelona, Spain
Methods Find Exp Clin Pharmacol 27:495-502. 2005..These proposals are classified into major and minor issues, and they are located in the corresponding parts of the article, as defined by the Introduction, Methods, Results, and Discussion (IMRAD) method...
- Surveying the literature from animal experiments: avoidance of bias is objective of systematic reviews, not meta-analysisKhalid S Khan
BMJ 331:110-1. 2005
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Instant replay' requiredH Edwin Kennah
Occupational and Environmental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Lab Anim (NY) 35:16-7. 2006
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Don't ignore the proposalMichael D Mann
Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA
Lab Anim (NY) 35:17. 2006
- Animal health assuranceJohn Donovan
Wyeth Research, Collegeville, Pennsylvania, USA
Curr Protoc Immunol . 2007..This unit addresses all three of these health management practices. Essential in support of these practices is a diagnostic laboratory capable of testing for rodent and rabbit pathogens...
- Report of the 2006 RSPCA/UFAW Rodent Welfare Group meetingBarney Reed
Research Animals Department, Science Group, RSPCA, Wilberforce Way, Southwater, West Sussex RH13 9RS, UK
Lab Anim (NY) 37:216-22. 2008..Topics included the housing and husbandry of mice and rats, refining the use of rodents in asthma research, good practice for the euthanasia of rodents using carbon dioxide and achieving reduction by sharing genetically modified mice...
- Grants proposals and animal use protocols: is the IACUC playing by the rules? Modular doesn't applyMichele Cunneen
The AWEN Group Inc, Waltham, MA, USA
Lab Anim (NY) 35:17-8. 2006
- Activists seek personhood for animalsR Scott Nolen
J Am Vet Med Assoc 223:759-60. 2003
- Laboratory animals and the art of empathyD Thomas
J Med Ethics 31:197-202. 2005..Again to be consistent, we should empathise with all who may be adversely affected by our behaviour. By this yardstick, too, animal experiments fail the ethical test...
- Science-based assessment of animal welfare: laboratory animalsV Baumans
Division of Laboratory Animal Science, Utrecht University, P O Box 80 166, 3508 TD Utrecht, the Netherlands Karolinska Institute, 17177 Stockholm, Sweden
Rev Sci Tech 24:503-13. 2005..In this paper, attention is paid to the assessment of welfare, environmental factors affecting welfare, legislative requirements and future trends such as the production and use of genetically modified animals...
- [Animal experiments recommended by the Japanese Pharmacological Society (evaluation and decrease of pain): introduction and new guidelines for animal experiments for the Japanese Pharmacological Society]Yasuo Ohno
Nihon Yakurigaku Zasshi 129:5-9. 2007
- [Inspection of laboratory animal facilities]Tsutomu Miki Kurosawa
Nihon Yakurigaku Zasshi 129:31-4. 2007
- Animal welfare, human healthNeville Goodman
Southmead Hospital, Bristol
Br J Hosp Med (Lond) 66:593. 2005
- [Importance of research on alternatives to animal experiments in pharmaceutical sciences]Yasuo Ohno
National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
Yakugaku Zasshi 128:735-40. 2008..Education on proper conduct of animal experiments (3Rs, methods to evaluate and decrease distress and pain, and methods of euthanasia) was not conducted in many institutes. Further improvement seems necessary...
- [New guidelines and standards in revised Animal Rights Act]Shuji Kurio
Nihon Seirigaku Zasshi 68:400-3. 2006
- Protocol audits for post-approval monitoring of animal use protocolsJamie F Smelser
Animal Welfare Program, University of California, San Diego, 9500 Gillman Dr, La Jolla, CA 92093, USA
Lab Anim (NY) 34:23-7. 2005..This program, as well as the protocol audit form they provide, can be used by institutions to initiate, enhance, or evaluate post-approval monitoring programs...
- [An essay on the topicality and problem complex. Ethics of the Reverence for Life]Judith Benz-Schwarzburg
Interfakultares Zentrum fur Ethik in den Wissenschaften IZEW, Universitat Tubingen, Germany
ALTEX 25:63-6. 2008..idea of the Reverence for Life obviously leads to ethical dilemmas - as for example in the case of animal experimentation. In many situations we cannot but kill or harm, even if we don't want to, and must live at the cost of ..
- Grants proposals and animal use protocols: is the IACUC playing by the rules? A word from OLAWCarol Wigglesworth
Office of Laboratory Animal Welfare, OER, OD, NIH, HHS
Lab Anim (NY) 35:18. 2006
- Animal experimentation in Japan: regulatory processes and application for microbiological studiesH Takahashi-Omoe
Science and Technology Foresight Center, National Institute of Science and Technology Policy, Ministry of Education, Culture, Sports, Science and Technology, Japan
Comp Immunol Microbiol Infect Dis 30:225-46. 2007We have conducted animal experimentation as a highly effective technique in biological studies. Also in microbiological studies, we have used experimentation to prevent and treat many infectious diseases in humans and animals...
- Human and animal subjects of research: the moral significance of respect versus welfareRebecca L Walker
Department of Social Medicine, University of North Carolina, CB 7240, Chapel Hill, North Carolina 27599 7240, USA
Theor Med Bioeth 27:305-31. 2006..While neither potential justification is sufficient to justify the regulatory difference as it stands, there is possible common ground between supporters of some regulatory difference and those rejecting the current difference...
- Making sense of multiple protocols and grant applications. Failure of compliance by confusion?Valerie Parkison
Tufts NEMC, Boston, MA, USA
Lab Anim (NY) 35:15-6. 2006
- Making sense of multiple protocols and grant applications. Room for improvementLara A Weaver
Division of Teaching and Research Resources, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA
Lab Anim (NY) 35:16-7. 2006
- Collaborative studies and animal reuse: one study, two institutionsBetsy L Bashaw
Animal Resources Facility, Albany Medical College, Albany, NY, USA
Lab Anim (NY) 37:61-2. 2008
- Report of the Working Group on Animal Distress in the LaboratoryMarilyn Brown
Charles River Laboratories Foundation, 251 Ballardvale Street, Wilmington, MA 01887, USA
Lab Anim (NY) 35:26-30. 2006....
- [Developments in the area of animal experiments in biomedical research]C F M Hendriksen
Nederlands Vaccin Instituut NVI en Nationaal Centrum Alternatieven voor dierproeven NCA, Universiteit Utrecht, Bilt hoven
Ned Tijdschr Geneeskd 150:2857-62. 2006..The point of departure in existing legislation on animal experimentation is the principle of 'responsible use'...
- [Inspection of laboratory animal breeding and husbandry/experiments on animals, examples]H Ratsch
Landesamt für Gesundheit und Soziales, Berlin
Dtsch Tierarztl Wochenschr 115:143-9. 2008..If in-house supervision works well, the State's role in regulating animal experiments can be reduced...
- Collaborative studies and animal reuse: the other IACUC should decideDebra L Hickman
VA Medical Center, Portland, OR, USA
Lab Anim (NY) 37:62-3. 2008
- Collaborative studies and animal reuse: a word from OLAW and USDAPatricia Brown
OLAW, OER, OD, NIH, HHS, USA
Lab Anim (NY) 37:63. 2008
- Collaborative studies and animal reuse: inter-related, not just relatedKathryn Nepote
Maryland Department of Agriculture, Animal Health Diagnostic Laboratory, College Park, MD, USA
Lab Anim (NY) 37:62. 2008
- An analysis of the Home Office Statistics of Scientific Procedures on Living Animals, Great Britain 2004Michelle Hudson
FRAME, Nottingham, NG1 4EE, UK
Altern Lab Anim 34:85-103. 2006..The use of non-human primates and dogs is also discussed. The implications of these latest statistics are considered with reference to the implementation of the Three Rs and their consequences for animal welfare...
- Establishing a culture of care, conscience, and responsibility: addressing the improvement of scientific discovery and animal welfare through science-based performance standardsH J Klein
Department of Laboratory Animal Resources, Merck Research Laboratories, Rahway, NJ, USA
ILAR J 48:3-11. 2007....
- Lack of progress with the replacement of animal models in medical researchCliff Goodman
Altern Lab Anim 34:127. 2006
- Punctual professor using passé procedures. Answer unclearAlan L Rothman
IACUC Member, University of Massachusetts Medical School, Worcester, MA, USA
Lab Anim (NY) 35:17-8. 2006
- Punctual professor using passé procedures. Cut the fundsWilliam Allen Hill
Department of Comparative Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
Lab Anim (NY) 35:18. 2006
- Of mice + medicineHoward Bell
Minn Med 90:30-5. 2007
- Modifications to husbandry and housing conditions of laboratory rodents for improved well-beingAbigail L Smith
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
ILAR J 46:140-7. 2005..Also suggested are possible inexpensive and effective enrichment schemes for laboratory mice that might include reducing the cage floor space per mouse combined with providing nesting material...
- Scientific procedures on living animals in Great Britain in 2003: the facts, figures and consequencesMichelle Hudson
FRAME, Russell and Burch House, 96 98 North Sherwood Street, Nottingham NG1 4EE, UK
Altern Lab Anim 32:473-85. 2004..The implications of these latest statistics are discussed with reference to key areas of interest and to the impact of existing regulations and pending legislative reforms...
- Britain seeks compromise on animal researchLaura Nelson
Nature 428:882. 2004
- Retiring to a chimp paradiseBridget M Kuehn
J Am Vet Med Assoc 222:565-6. 2003
- Sparing animals and progressing in scienceAmalia Guaitani
Trends Pharmacol Sci 24:616-7. 2003
- Using grounded theory to examine people's attitudes toward how animals are usedSarah Knight
University of Portsmouth, Department of Psychology, King Henry Building, King Henry Stree, Portsmouth, UK PO1 2DY
Soc Anim 11:307-27. 2003..This paper discusses how such views may be justified and maintained...
- Animal experimentation as perceived by the citizens of Britain and FranceMichael Balls
Altern Lab Anim 31:83-4. 2003
- [Developments in the area of animal experiments in biomedical research]J C Molenaar
Ned Tijdschr Geneeskd 151:565; author reply 565. 2007
- Clinical blood draws: when do they require IACUC approval?Stacy Pritt
Animal Resources Facility, Joslin Diabetes Center, Boston, MA, USA
Lab Anim (NY) 33:17-21. 2004
- [Whereabouts of surplus and surviving laboratory animals]Dorothea Doehring
Institut fuer Tierschutz, Verhaltenskunde und Tierhygiene der Tieraerztlichen Fakultaet der Ludwig Maximilians Universitaet, D Muenchen
ALTEX 22:7-11. 2005..Using such an organisation, the re-homing process is to a great extend safe and anonymous for the research institution. Many institutions already made very good experiences in the cooperation with welfare organisations...
- The impact of the introduction of the ethical review process for research using animals in the UK: implementation of policyIain F H Purchase
Institute of Medicine, Law and Bioethics and School of Biological Sciences, University of Manchester, UK
Lab Anim 36:68-85. 2002..A smaller proportion of respondents believed that the ERP has had a beneficial impact on animal work and training. Nearly all the respondents viewed animal care and accommodation as good or excellent...
- Effects of Testosterone and Genetic Factors on Psychological and Motor Function iNICOLE RENEE TARTAGLIA; Fiscal Year: 2013....
- Physiology of Hypothalamic Neurosteroidal ProgesteronePaul E Micevych; Fiscal Year: 2013..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
- Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of PregnanShao Lin; Fiscal Year: 2013..The multidisciplinary research team has a unique opportunity to use the data already collected and geo-coded through the NBDPS and other ongoing projects, which ensures the project is feasible and sustainable. ..
- Gross Hall Animal Resource CenterSusan V Bryant; Fiscal Year: 2010....
- Regional Biocontainment LaboratoryCharles Bailey; Fiscal Year: 2007..The Provost and Chief Financial Officer have committed the University to pay these costs as appropriate should they exceed the balance of the start-up contingency fund. ..
- Protein Phosphatase Regulation of the Principal Renal Sodium Transporter NHE3Ion Alexandru Bobulescu; Fiscal Year: 2013....
- Roles of Gs Alpha and interaction with Wnt signaling in regulation of adipocyte dPartha S Sinha; Fiscal Year: 2011..PUBLIC HEALTH RELEVANCE: This study focuses on mechanisms underlying how fat cells and bone cells develop from the bone marrow. This may help improve understanding and treatment of diseases such as obesity and osteoporosis. ..
- Mechanisms of Lipid-Induced Hepatic Insulin ResistanceGerald I Shulman; Fiscal Year: 2013....
- MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHMARK WALTER FRAMPTON; Fiscal Year: 2013..by didactic courses, seminars, conferences, journal clubs, and instruction in research ethics, human and animal experimentation, and grant writing...
- REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORSGREGORY SCOTT SCHULTZ; Fiscal Year: 2012....
- VCU Building Interdisciplinary Research Careers in Women's HealthJerome F Strauss; Fiscal Year: 2011....
- Improving Air Quality for Laboratory Animal ResearchSharron S Quisenberry; Fiscal Year: 2010..A Project Liaison Officer will assist with communications and coordination among the key scientists and other Key Personnel. ..
- Mechanisms of Hormonal Regulation of the Sodium Chloride CotransporterRobert S Hoover; Fiscal Year: 2013..Mammalian cell culture, isolated tubule microperfusion and whole animal experimentation will be utilized to examine effects at the cellular/molecular, tubular and organismal level...
- In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRSAdil Bashir; Fiscal Year: 2013..The proposed project aims to develop new methodology to measure and understand energy disorders in cardiovascular disease and the techniques developed will be critically useful to advance basic research and medical care. ..
- Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesisCezary Marcinkiewicz; Fiscal Year: 2012..Investigation of this receptor may be beneficial for cancer as well as for cardiovascular disease having patients, because regulation of vascularization process is important in these pathologies. ..
- Functional analysis of Chk2 in DNA damage responseJun Hyun Kim; Fiscal Year: 2013....
- Novel Therapies and Biomarkers for the MucopolysaccharidosesCALOGERA MARIA SIMONARO; Fiscal Year: 2013..Each of the four molecules to be studied has already shown efficacy in animal models of arthritis, and one (Remicade") is clinically available. ..
- Inflammasome Activation in Complex Regional Pain SyndromeWade S Kingery; Fiscal Year: 2013....
- Mathematical Modeling of Inflammation in ARDSYoram Vodovotz; Fiscal Year: 2010..End of Abstract) ..
- Mathematical Modeling of Inflammation in ARDSGary F Nieman; Fiscal Year: 2010..End of Abstract) ..
- Molecular and Cellular Determinants of the Exercise Pressor Reflex in CHFIrving H Zucker; Fiscal Year: 2013..Furthermore, w believe that these data will uncover new targets for therapy in CHF. ..
- A short course: An organ systems approach to target the Metabolic syndromeOwen P McGuinness; Fiscal Year: 2012..The benefit to human disease is that these trainees will now be equipped with the tools necessary to fill a void in our training programs. ..
- WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCEJin Moo Lee; Fiscal Year: 2010..Data sharing provides great dividends by facilitating comparisons between disease models, and allowing new research findings on existing data without having to perform additional animal experiments. ..
- Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and StructureKarin Schon; Fiscal Year: 2011..This set of studies aims to examine the relationship between aging, exercise, and the brain in healthy young and older individuals. ..
- Epidemiology & epigenetics: Maternal diet, DNA methylation, & offspring adiposityMatthew W Gillman; Fiscal Year: 2010..Second is public health importance-- optimizing maternal diet in early pregnancy could improve the health of the next generation. ..
- Integrative Neural Systems Underlying Vital Aerodigestive Tract FunctionsJoanne Robbins; Fiscal Year: 2010..The conference will provide a unique forum for established scholars and their doctoral students and fellows from multiple inter-related disciplines to interact, share ideas, present, collaborate and make important contributions. ..
- Aging Auditory System: Presbycusis and Its Neural BasesRobert D Frisina; Fiscal Year: 2013..SPECIFIC AIM 3: Investigate the Neural Bases and Possible Reversibility of the Accelerated Age-Related Hearing Loss Associated with Medical Conditions: Ear and Brain Analyses. ..
- College of Medicine Phoenix Campus Vivarium Phase I ConstructionWilliam M Crist; Fiscal Year: 2010..The best and only way to assure optimal standards of experimental animal care required for our PHS-supported research efforts is to construct this dedicated laboratory animal vivarium serving the Phoenix Biomedical Campus. ..
- NORADRENERGIC SYSTEM IN DEPRESSIONGREGORY ALLEN ORDWAY; Fiscal Year: 2012..Understanding the molecular pathology of this disorder holds the promise of identifying new biological targets for the development of improved treatments. ..
- In Utero Exposure to Bisphenol A: Effects on the Fetal EpigenomeDANA DOLINOY; Fiscal Year: 2013....
- Body Burden of PAHs and Cardiovascular Disease in the United StatesJOHN DAVIS CLARK; Fiscal Year: 2010..Results of this proposed study can be used to influence policy decisions and resource allocation for the prevention of cardiovascular disease. ..
- Endothelial Injury in Endotoxin-Induced Acute Renal FailurePatrick N Cunningham; Fiscal Year: 2013....
- Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl PathGeorge I Henderson; Fiscal Year: 2010..We will determine how the toxins damage it (to prevent this from happening), and how this system is normally controlled. ..
- High Sensitivity Mobile PET for Brain Imaging and Proton Therapy MonitoringGeorges El Fakhri; Fiscal Year: 2010....
- Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and StructureKarin Schon; Fiscal Year: 2013..Regular moderate intensity aerobic exercise may have neuroprotective effects throughout the lifespan. ..
- Biocompatibility of Implantable Renal Replacement DevicesShuvo Roy; Fiscal Year: 2013....
- Mechamism of Activation of Oxidative Metabolism in vivo During ExerciseJESSICA ROSE SPIRES; Fiscal Year: 2012....
- HORMONAL REGULATION OF BLOOD PRESSUREMichal Laniado Schwartzman; Fiscal Year: 2013..ular tone, in the pathophysiology of hypertension and cardiovascular disease. ..
- Engineering of Human Corneal Endothelial GraftsYing Ting Zhu; Fiscal Year: 2012..Furthermore, the said technology may also be applied to engineer other similar tissues, such as the retinal pigment epithelium, in the future. ..
- Mechanisms of Altered Glucose Metabolism in Sleep-Disordered BreathingNaresh Punjabi; Fiscal Year: 2013....
- Construction of a Dual Function Primate Facility: ABSL3 and Transplant MedicineStuart M Zola; Fiscal Year: 2010....
- Cyclotron for PET RadiopharmaceuticalsJogeshwar Mukherjee; Fiscal Year: 2013....
- CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELSNicholas D Schiff; Fiscal Year: 2013..The studies proposed here will help to advance the necessary knowledge to advance and further develop a novel application of electrical brain stimulation aimed at improving the lives of patients suffering with these lifelong challenges. ..
- Determinants of Nicotine Reinforcement Thresholds and Demand Elasticity in RatsMark G LeSage; Fiscal Year: 2013..As such, the present study could contribute to the scientific basis for evaluation of reduced nicotine tobacco products and their clinical and public health consequences. ..
- Sensitivity to smoking reinforcement in women: menstrual cycle effectsElizabeth Van Voorhees; Fiscal Year: 2012....
- Role of C/EBPbeta in mechanical regulation of MSC potentialMaya Styner; Fiscal Year: 2013....
- Integrative Lipid Metabolism, Inflammation, and Chronic DiseasesJohn S Parks; Fiscal Year: 2013..Training will involve an integrated, multidisciplinary approach that uses molecular, cellular, and whole animal experimentation. Training for students will include rigorous didactic courses, seminars, journal clubs, Program Project ..
- One Health Innovation Fellowships for Zoonotic Disease Research In MongoliaGREGORY CHARLES GRAY; Fiscal Year: 2013..abstract_text> ..
- Gene Expression, Compensation Mechanisms, and Successful Cognitive AgingCARL WAYNE COTMAN; Fiscal Year: 2013..Accordingly, these studies will help provide a rational for including exercise as a formula to promote successful cognitive health during aging. ..
- Age Dependent Mechanical Ventilator-Induced Inflammation: Modeling &ExperimentsANGELA MARIE REYNOLDS; Fiscal Year: 2013....
- Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall IschemiaRavinder K Mittal; Fiscal Year: 2013..With the better understanding of pathogenesis of pain, we hope more effective strategies to treat esophageal pain will be forthcoming. ..
- Pre- and peri-natal predictors of childhood obesityMatthew W Gillman; Fiscal Year: 2013..The results of this research will lead to new scientific knowledge about the drivers of growth and adiposity in childhood and may very well lead to new avenues for prevention of obesity, diabetes, and cardiovascular disease. ..
- Dissecting expression divergence in developmental networks across DrosophilidsZEBA BATOOL WUNDERLICH; Fiscal Year: 2013..The department and university has a number of faculty members with interests that overlap with mine and also provides the animal husbandry, microscopy, computational and administrative resources that will enable this project. ..
- Nanotechnology enabled desktop image-guided microbeam radiation therapy systemOTTO Z contact ZHOU; Fiscal Year: 2010..If human patients response to MRT in similar ways as reported in numerous MRT animal studies, MRT will literally revolutionize cancer treatment. ..
- Force Clamp Systems for Evaluation of MechanotransductionBETH L PRUITT; Fiscal Year: 2013....
- Effector and regulatory T cell responses and protection from clinical malariaMargaret E Feeney; Fiscal Year: 2013..but not liver-stage malaria, will be compared to children who do not receive chemoprevention, and these immune parameters will be correlated with prospective protection from clinical malaria following cessation of chemoprevention ..
- An XFM Interventional Guidance System for Cardiac Resynchronization TherapyReza Nezafat; Fiscal Year: 2012....
- Nicotine delivery to rodents with lung alveolar region-targeted aerosol techXinmin Simon Xie; Fiscal Year: 2011..Furthermore, this method will serve as a platform to develop more effective and safer medications for smoking cessation and treatment of tobacco-related diseases. ..
- An Animal Biosafety Level 3 Laboratory for Stony Brook UniversitySamuel L Stanley; Fiscal Year: 2010....
- Inhibition of Lung Carcinogenesis by Tea Polyphenols and AtorvastatinChung S Yang; Fiscal Year: 2012..The possible use of the combination of tea polyphenols and Lipitor for lung cancer prevention is an attractive strategy and could have a large impact in public health. ..
- Toll-like receptors and intestinal inflammationCharalabos Pothoulakis; Fiscal Year: 2010..Our proposed studies will provide significant information relevant to the pathogenesis of colonic inflammation, including IBD. ..
- Self Organized Criticality as a new paradigm of sleep regulationPLAMEN CHRISTOV IVANOV; Fiscal Year: 2013....
- Bladder Voiding via Pudendal Nerve BlockKENNETH GUSTAFSON; Fiscal Year: 2009..In addition, the substantial potential future clinical impact from HF nerve block to a number of other clinical applications, such as chronic pain, muscle spasticity, etc. increases the value of this work. ..
- Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and CJames McAllister; Fiscal Year: 2009..We expect that this conference will create a substantial increase in the quality and quantity of hydrocephalus research similar to the advances gained from the previous workshop. ..
- Exchangeable Heart Valve for Tissue Engineering ApplicationsIvan Vesely; Fiscal Year: 2007..VXI will thus continue to advance the field of heart valve technologies into new areas where innovative solutions for patients with heart valve disease are needed. [unreadable] [unreadable] [unreadable]..
- In Vivo Optical Imaging Scanner for Small Animal ResearchSTUART BERR; Fiscal Year: 2009....
- EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAMJohn Blake; Fiscal Year: 2005..We are recognizably weak in PHS funding but we have confidence in our new scientists and we are motivated to provide the necessary environment for them to succeed. ..
- MRI-Guided Angioplasty of Renal Artery StenosisReed Omary; Fiscal Year: 2005..MRI guidance will also avoid the ionizing radiation exposure of x-rays and the potential kidney toxicity of iodinated contrast agents. ..
- Cardiovascular Inflammation Function Imaging by Photoacoustics using Gold NanorodKang Kim; Fiscal Year: 2010..This method also can be rapidly translated into clinical practice since it is based upon novel processing of ultrasound data that can be obtained with commercially available scanners. ..
- Adenosine and Nitric Oxide DeficiencyItalo Biaggioni; Fiscal Year: 2004....
- MODEL OF DYSRHYTHMIAS AFTER CONGENITAL HEART SURGERYArthur Garson; Fiscal Year: 1991....
- MECHANISMS OF PULMONARY FIBROSIS CAUSED BY SILICAGerald Davis; Fiscal Year: 2003..And other interstitial lung diseases where the cause is not known and treatment is not effective. ..
- ANIMAL FACILITY IMPROVEMENTTERESA SYLVINA; Fiscal Year: 1992..5. Meet NIH and USDA standards for housing cats and monkeys and enhance their psychological well-being by replacing existing caging with new stainless steel cages. ..
- NEURONAL BASIS OF VISUAL PERCEPTION IN EYE MOVEMENTSHitoshi Sato; Fiscal Year: 1991....
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESPatrick Manning; Fiscal Year: 1992..The program is part of a centralized program of laboratory animal care on the Twin Cities Campus...