Genomes and Genes
Summary: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
Publications357 found, 100 shown here
- Clinical end points in coronary stent trials: a case for standardized definitionsDonald E Cutlip
Harvard Clinical Research Institute, Harvard Medical School, 930 Commonwealth Avenue, Boston, MA 02215, USA
Circulation 115:2344-51. 2007Although most clinical trials of coronary stents have measured nominally identical safety and effectiveness end points, differences in definitions and timing of assessment have created confusion in interpretation.
- In vivo evaluation of patency and in-stent stenoses after implantation of nitinol stents in iliac arteries using MR angiographyOkka W Hamer
Department of Diagnostic Radiology, University Hospital of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
AJR Am J Roentgenol 185:1282-8. 2005....
- A polymer-based, paclitaxel-eluting stent in patients with coronary artery diseaseGregg W Stone
Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York 10022, USA
N Engl J Med 350:221-31. 2004..Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site of vascular injury may reduce the incidence of neointimal hyperplasia and restenosis...
- Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary arteryJeffrey W Moses
Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute of New York, New York 10021, USA
N Engl J Med 349:1315-23. 2003..Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly reduces the risk of restenosis after percutaneous coronary revascularization...
- Pathology of drug-eluting stents in humans: delayed healing and late thrombotic riskMichael Joner
CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
J Am Coll Cardiol 48:193-202. 2006This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST).
- Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysisChristoph Stettler
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Lancet 370:937-48. 2007Whether the two drug-eluting stents approved by the US Food and Drug Administration-a sirolimus-eluting stent and a paclitaxel-eluting stent-are associated with increased risks of death, myocardial infarction, or stent thrombosis compared ..
- Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implicationsThomas F Luscher
Cardiovascular Center, University of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
Circulation 115:1051-8. 2007..Since the introduction of drug-eluting stents (DES), most interventional centers have noted stent thrombosis up to 3 years after implantation, a complication ..
- Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysisTullio Palmerini
Istituto di Cardiologia, Policlinico S Orsola, Bologna, Italy
Lancet 379:1393-402. 2012The relative safety of drug-eluting stents and bare-metal stents, especially with respect to stent thrombosis, continues to be debated...
- Stenting versus endarterectomy for treatment of carotid-artery stenosisThomas G Brott
Mayo Clinic, Griffin 304, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
N Engl J Med 363:11-23. 2010..Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke...
- Drug-eluting vs bare-metal stents in primary angioplasty: a pooled patient-level meta-analysis of randomized trialsGiuseppe De Luca
Division of Cardiology, Ospedale Maggiore della Carita, Eastern Piedmont University, Novara, Italy
Arch Intern Med 172:611-21; discussion 621-2. 2012..was to perform a meta-analysis using individual patient data to evaluate the long-term safety and effectiveness of DES compared with bare-metal stents (BMS) in patients undergoing primary percutaneous coronary intervention for STEMI.
- Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trialManel Sabate
University Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Lancet 380:1482-90. 2012..We report the 1-year result of the EXAMINATION (clinical Evaluation of the Xience-V stent in Acute Myocardial INfArcTION) trial, comparing EES with bare-metal stents (BMS) in patients with STEMI.
- Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphateLaurent Bonello
Department of Cardiology, Institut National de la Santè et de la Recherche Médicale Unité Mixte de Recherche 608, Hopital Universitaire Nord, Faculte de Medecine, Marseille, France
J Am Coll Cardiol 56:919-33. 2010..This review provides a consensus opinion on the definition of high on-treatment platelet reactivity to ADP based on various methods reported in the literature and proposes how this measurement may be used in the future care of patients...
- Cytochrome p-450 polymorphisms and response to clopidogrelJessica L Mega
Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 360:354-62. 2009..Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function...
- Remodeling technique for endovascular treatment of ruptured intracranial aneurysms had a higher rate of adequate postoperative occlusion than did conventional coil embolization with comparable safetyLaurent Pierot
Department of Neuroradiology, Reims University, Hopital Maison Blanche, 45 rue Cognacq Jay, 51092 Reims, France
Radiology 258:546-53. 2011....
- Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation modelKatarina Larsen
Molecular Cardiology Laboratory, Ee2389a, Experimental Cardiology, Thoraxcenter, Erasmus University Medical Center, s Gravendijkwal 230, 3015 GE Rotterdam, The Netherlands
Eur Heart J 33:120-8. 2012..Here, we assessed the function of the GS in comparison to bare-metal stent (BMS), when exposed to the human and animal circulation...
- Neuroform stent-assisted coil embolization of wide-neck intracranial aneurysms: strategies in stent deployment and midterm follow-upAlessandra Biondi
Division of Interventional Neuroradiology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
Neurosurgery 61:460-8; discussion 468-9. 2007..To evaluate the midterm results of intracranial stent-assisted coil embolization in the treatment of wide-necked cerebral aneurysms and to assess the efficacy of various strategies used in stent deployment...
- Treatment of intracranial aneurysms by functional reconstruction of the parent artery: the Budapest experience with the pipeline embolization deviceI Szikora
Department of Neuroradiology, National Institute of Neurosurgery, Amerikai ut 57, Budapest, Hungary
AJNR Am J Neuroradiol 31:1139-47. 2010..The use of mesh tubes has recently gained traction as an alternative therapy. This article summarizes the midterm results of using an endoluminal sleeve, the PED, in the treatment of aneurysms...
- Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort studyJoost Daemen
Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
Lancet 369:667-78. 2007Stent thrombosis is a safety concern associated with use of drug-eluting stents. Little is known about occurrence of stent thrombosis more than 1 year after implantation of such stents.
- Inflammation and restenosis in the stent eraFrederick G P Welt
Department of Medicine, Cardiac Catheterization Laboratory and Coronary Care Unit, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 22:1769-76. 2002..The widespread use of coronary stents has fundamentally altered the vascular response to injury by causing a more intense and prolonged inflammatory ..
- Expandable metal stents for endoscopic bilateral stent-within-stent placement for malignant hilar biliary obstructionPrabhleen Chahal
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastrointest Endosc 71:195-9. 2010Placement of biliary stents is effective for palliation of unresectable hilar malignant biliary obstruction. However, when bilateral self-expandable metal stents (SEMSs) are used, placement can be technically challenging...
- Improved clinical outcome using polytetrafluoroethylene-coated stents for TIPS: results of a randomized studyChristophe Bureau
Service d Hepato gastro enterologie, Fédération Digestive, Centre Hospitalier Universitaire Purpan et U531 Institut National de la Santé et de la Recherche Médicale, Toulouse, France
Gastroenterology 126:469-75. 2004..Preliminary experimental and clinical studies suggest that the use of stents covered with polytetrafluoroethylene could tremendously decrease this risk.
- The road to bioabsorbable stents: reaching clinical reality?Paul Erne
Division of Cardiology, Kantonsspital Luzern, Luzern 16 CH 6000, Switzerland
Cardiovasc Intervent Radiol 29:11-6. 2006..of conventional (permanent-implant) stent therapy; even with the innovation and promising benefits of drug-eluting stents, management of ISR is very difficult...
- Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trialJörg Ederle
Institute of Neurology, University College London, Box 6, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Lancet 375:985-97. 2010b>Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy...
- Clinical outcomes after heterogeneous overlap stenting with drug-eluting stents and bare-metal stents for de novo coronary artery narrowingsJiro Aoki
Center for Interventional Vascular Therapy, Columbia University Medical Center, New York, NY, USA
Am J Cardiol 101:58-62. 2008When it is difficult to deliver multiple drug-eluting stents (DES) or when size constraints limit DES implantation, bare-metal stents (BMS) may be implanted contiguous to DES...
- Unilateral versus bilateral endoscopic metal stenting for malignant hilar biliary obstructionItaru Naitoh
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Gastroenterol Hepatol 24:552-7. 2009..The aim of this study was to compare endoscopic unilateral versus bilateral drainage in patients with malignant hilar biliary obstruction using a self-expanding metal stent (SEMS)...
- Fixation of a modified covered esophageal stent: its clinical usefulness for preventing stent migrationC S Shim
Dept of Internal Medicine, Institute for Digestive Research, Soon Chun Hyang University College of Medicine, Seoul, Korea
Endoscopy 33:843-8. 2001Membrane-covered self-expandable metal stents are effective in preventing tumor ingrowth and stent obstruction in patients with inoperable esophageal cancer, but migration of stents continues to be a major problem...
- Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantationNicoline J Breet
Department of Cardiology, St Antonius Hospital, PO Box 2500, 3435 CM Nieuwegein, The Netherlands
JAMA 303:754-62. 2010..None of the tests provided accurate prognostic information to identify patients at higher risk of bleeding following stent implantation. Trial Registration clinical trials.gov Identifier: NCT00352014 [corrected]...
- Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelializationAloke V Finn
Cardiac Unit, Department of Internal Medicine, Massachusetts General Hospital, Boston, USA
Circulation 115:2435-41. 2007..Although the clinical predictors of LST have been reported, specific morphological and histological correlates of LST remain unknown...
- The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stentsGaku Nakazawa
CVPath Institute, Inc, Gaithersburg, Maryland, USA
J Am Coll Cardiol 57:1314-22. 2011Human coronary bare-metal stents (BMS) and drug-eluting stents (DES) from autopsy cases with implant duration >30 days were examined for the presence of neointimal atherosclerotic disease.
- Pooled analysis of the efficacy and safety of self-expanding metal stenting in malignant colorectal obstructionShaji Sebastian
Department of Gastroenterology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland
Am J Gastroenterol 99:2051-7. 2004Self-expanding metal stents have been used in the management of colorectal obstruction as an alternative to emergency surgery...
- Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up studyPieter J Vlaar
Department of Cardiology, University Medical Centre Groningen, University of Groningen, Netherlands
Lancet 371:1915-20. 2008..We aimed to investigate whether the early efficacy of thrombus aspiration seen in TAPAS translated into clinical benefit after 1 year...
- Long-Term (>10 Years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stentsSoji Nishio
Department of Cardiology, Shiga Medical Center for Adults, 5 4 30, Moriyama, Moriyama City, Shiga, 524 8524 Japan
Circulation 125:2343-53. 2012..The purpose of this study was to evaluate the long-term safety of the Igaki-Tamai stent, the first-in-human fully biodegradable coronary stent made of poly-l-lactic acid...
- Outcomes with various drug eluting or bare metal stents in patients with diabetes mellitus: mixed treatment comparison analysis of 22,844 patient years of follow-up from randomised trialsSripal Bangalore
New York University School of Medicine, New York, NY 10016, US
BMJ 345:e5170. 2012To evaluate the efficacy and safety of currently used drug eluting stents compared with each other and compared with bare metal stents in patients with diabetes.
- Balloon angioplasty versus stenting with nitinol stents in intermediate length superficial femoral artery lesionsPetra Dick
Department of Angiology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria, Europe
Catheter Cardiovasc Interv 74:1090-5. 2009..We reinvestigated whether primary nitinol stenting is associated with a morphologic and clinical benefit when compared with percutaneous transluminal angioplasty with optional stenting (PTA) in intermediate-length lesions...
- Vascular responses to drug eluting stents: importance of delayed healingAloke V Finn
CVPath Institute, Inc, 19 Firstfield, Road, Gaithersburg, MD 20878, USA
Arterioscler Thromb Vasc Biol 27:1500-10. 2007Polymer-based sirolimus- (Cypher) and paclitaxel-eluting (Taxus) drug eluting stents have become the treatment of choice for patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention (PCI)...
- Coronary stents: current statusScot Garg
Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
J Am Coll Cardiol 56:S1-42. 2010Coronary artery stents revolutionized the practice of interventional cardiology after they were first introduced in the mid-1980s...
- Long-term safety and efficacy of drug-eluting versus bare-metal stents in SwedenStefan K James
Department of Cardiology, Uppsala University Hospital, Uppsala, Sweden
N Engl J Med 360:1933-45. 2009The long-term safety and efficacy of drug-eluting coronary stents have been questioned.
- Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trialLiesbeth Bax
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
Ann Intern Med 150:840-8, W150-1. 2009..Little is known about the efficacy and safety of renal artery stenting in patients with atherosclerotic renal artery stenosis (ARAS) and impaired renal function...
- Self-expanding metal stents for gastroduodenal malignancies: systematic review of their clinical effectivenessA Dormann
Dept of Medicine, Minden Hospital, Minden, Germany
Endoscopy 36:543-50. 2004..Recently, metal stents have emerged as a new therapeutic option...
- Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stentsIoannis Iakovou
Centro Cuore Columbus and San Raffaele Hospital, Milan, Italy
JAMA 293:2126-30. 2005..However, delayed endothelialization associated with the implantation of drug-eluting stents may extend the risk of thrombosis beyond 30 days...
- Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularizationStephan Windecker
Department of Cardiology, University Hospital Bern, Bern, Switzerland
N Engl J Med 353:653-62. 2005Sirolimus-eluting stents and paclitaxel-eluting stents, as compared with bare-metal stents, reduce the risk of restenosis. It is unclear whether there are differences in safety and efficacy between the two types of drug-eluting stents.
- Long-term impact of chronic kidney disease in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial InAdam J Saltzman
Columbia University Medical Center and the Cardiovascular Research Foundation, New York, New York, USA
JACC Cardiovasc Interv 4:1011-9. 2011..This study sought to investigate the impact of chronic kidney disease (CKD) in patients undergoing percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) with different antithrombotic strategies...
- Impact of retrievable stents on acute ischemic stroke treatmentC Brekenfeld
University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern, Switzerland
AJNR Am J Neuroradiol 32:1269-73. 2011Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices...
- Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapyEugene P McFadden
Thoraxcenter, Erasmus University, Rotterdam, Netherlands
Lancet 364:1519-21. 2004Although the safety profiles of coronary stents eluting sirolimus or paclitaxel do not seem to differ from those of bare metal stents in the short-to-medium term, concern has arisen about the potential for late stent thromboses related to ..
- Guidelines for the reporting of renal artery revascularization in clinical trials. American Heart AssociationJohn H Rundback
Circulation 106:1572-85. 2002
- Stent-assisted coiling of intracranial aneurysms: clinical and angiographic results in 216 consecutive aneurysmsMichel Piotin
Service de Neuroradiologie Interventionnelle et Fonctionnelle, Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild, 25 29 Rue Manin 75940 Paris, Cedex 19, France
Stroke 41:110-5. 2010..We present our experience with stent-assisted coiling with special emphasis on procedure-related neurological complications and incidence of angiographic recurrence...
- Evaluation of the Medtronic (Driver) cobalt-chromium alloy coronary stent systemMichael H Sketch
Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Cardiol 95:8-12. 2005..07 mm before the procedure, and mean lesion length was 11.04 mm. Fifty-one patients received multiple stents. Angiographic success rate was 100% and procedural success rate was 98.3%...
- The effectiveness of percutaneous transluminal angioplasty for the treatment of critical limb ischemia: a 10-year experienceToshifumi Kudo
Gonda Vascular Center, University of California at Los Angeles, 200 UCLA Medical Plaza, Los Angeles, CA 90095 6958, USA
J Vasc Surg 41:423-35; discussion 435. 2005..To determine the efficacy, safety, and long-term results, including continued clinical improvement and limb salvage, of percutaneous transluminal angioplasty (PTA) in patients with critical limb ischemia (CLI)...
- Usefulness of slimmer and open-cell-design stents for endoscopic bilateral stenting and endoscopic revision in patients with hilar cholangiocarcinoma (with video)Jeong Yeol Kim
Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Yangsan, Korea
Gastrointest Endosc 70:1109-15. 2009....
- Endoscopic removal of malfunctioning biliary self-expandable metallic stentsPietro Familiari
Digestive Endoscopy Unit, Catholic University, Rome, Italy
Gastrointest Endosc 62:903-10. 2005Endoscopic removal of malfunctioning self-expandable metallic biliary stents (SEMS) is difficult and not well described...
- Optical coherence tomography assessment of the acute effects of stent implantation on the vessel wall: a systematic quantitative approachN Gonzalo
Thoraxcenter, Erasmus MC, 3015 CE Rotterdam, The Netherlands
Heart 95:1913-9. 2009....
- Optical coherence tomography patterns of stent restenosisNieves Gonzalo
Thoraxcenter, Erasmus MC, Rotterdam 3015 CE, The Netherlands
Am Heart J 158:284-93. 2009..Stent restenosis is an infrequent but poorly understood clinical problem in the drug-eluting stent era. The aim of the study was to evaluate the morphologic characteristics of stent restenosis by optical coherence tomography (OCT)...
- Endoscopic bilateral metal stent placement for advanced hilar cholangiocarcinoma: a pilot study of a newly designed Y stentJung Hyun Lee
Department of Internal Medicine, Pusan National University College of Medicine, Seo Gu, Busan, Korea
Gastrointest Endosc 66:364-9. 2007..endoscopic stent placement is now generally accepted as a palliative method of treatment in unresectable hilar cholangiocarcinoma, exclusively endoscopic placement of bilateral metal stents has been considered very difficult and complex.
- Stents for intracranial wide-necked aneurysms: more than mechanical protectionIsabel Wanke
Department of Diagnostic and Interventional, Radiology and Neuroradiology, University Hospital of Essen, Essen, Germany
Neuroradiology 50:991-8. 2008..Endovascular stents are one tool that can be deployed to solve this essentially mechanical problem...
- Incomplete stent apposition and very late stent thrombosis after drug-eluting stent implantationStephane Cook
Department of Cardiology, University Hospital Bern, 3010 Bern, Switzerland
Circulation 115:2426-34. 2007..The present study investigated differences of the stented segment between patients with and without very late stent thrombosis with the use of intravascular ultrasound...
- The results of total arch graft implantation with open stent-graft placement for type A aortic dissectionMasaaki Kato
Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Saitama Medical School, Saitama, Japan
J Thorac Cardiovasc Surg 124:531-40. 2002..To address this problem, we have developed a new method for type A aortic dissection: total arch graft implantation with open-style stent-graft placement...
- Optimum palliation of inoperable hilar cholangiocarcinoma: comparative assessment of the efficacy of plastic and self-expanding metal stentsRamu P Raju
Department of Gastroenterology, Hepatology, and Nutrition, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1466, Houston, TX 77030 4009, USA
Dig Dis Sci 56:1557-64. 2011Endoscopic retrograde biliary drainage (ERBD) with plastic or self-expanding metal stents (SEMS) is often performed for palliative care for cholangiocarcinoma.
- Extensive primary repair of the thoracic aorta in acute type a aortic dissection by means of ascending aorta replacement combined with open placement of triple-branched stent graft: early resultsLiang Wan Chen
Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, China
Circulation 122:1373-8. 2010..To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported...
- Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantationEric L Eisenstein
Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
JAMA 297:159-68. 2007Recent studies of drug-eluting intracoronary stents suggest that current antiplatelet regimens may not be sufficient to prevent late stent thrombosis.
- The NIH registry on use of the Wingspan stent for symptomatic 70-99% intracranial arterial stenosisO O Zaidat
Associate Medical College of Wisconsin Froedtert Hospital, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
Neurology 70:1518-24. 2008..The Wingspan intracranial stent is another therapeutic option but there are limited data on the technical success of stenting and outcome of patients with 70% to 99% stenosis treated with a Wingspan stent...
- Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stentsGiulio Guagliumi
Division of Cardiology, Cardiovascular Department, Ospedali Riuniti di Bergamo, Bergamo, Italy
JACC Cardiovasc Interv 3:531-9. 2010We designed a randomized trial exploiting optical coherence tomography (OCT) to assess coverage and apposition of overlapping bare-metal stents (BMS) and drug-eluting stents (DES) in human coronary arteries.
- Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trialGregg W Stone
New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10022, USA
Lancet 377:2193-204. 2011..Primary results of the HORIZONS-AMI trial have been previously reported. In this final report, we aimed to assess 3-year outcomes...
- A comparison of functional and physical properties of self-expanding intracranial stents [Neuroform3, Wingspan, Solitaire, Leo+, Enterprise]O Krischek
Klinik für Neuroradiologie, Klinikum Stuttgart, Stuttgart, Germany
Minim Invasive Neurosurg 54:21-8. 20115 self-expanding intracranial stents Neuroform (N), Wingspan (W), Solitaire (S), Leo(+) (L), and Enterprise (E) were subjected to an in vitro examination and comparison of their physical features and functional properties in order to ..
- Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeysKensuke Egashira
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Arterioscler Thromb Vasc Biol 27:2563-8. 2007..The aim of this study was to determine the in vivo efficacy and safety of local delivery of 7ND gene via the gene-eluting stent in reducing in-stent neointima formation in rabbits and in cynomolgus monkeys...
- High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stentsBoris Polyak
Department of Surgery, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Proc Natl Acad Sci U S A 105:698-703. 2008..that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (i) preloading cells with biodegradable polymeric superparamagnetic ..
- Balloon angioplasty versus implantation of nitinol stents in the superficial femoral arteryMartin Schillinger
Department of Angiology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria
N Engl J Med 354:1879-88. 2006..We evaluated whether primary implantation of a self-expanding nitinol (nickel-titanium) stent yielded anatomical and clinical benefits superior to those afforded by percutaneous transluminal angioplasty with optional secondary stenting...
- A single-center study of Wingspan stents for symptomatic atherosclerotic stenosis of the middle cerebral arteryLei Zhang
Department of Neurosurgery, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China
J Clin Neurosci 20:362-6. 2013..with symptomatic MCA stenosis with narrowing of at least 70% among 61 patients were treated using Wingspan stents from March 2007 to December 2010. Clinical outcomes and imaging features were recorded and analyzed...
- Stent-supported aneurysm coiling: a literature survey of treatment and follow-upM Shapiro
Bernard and Irene Schwartz Neurointerventional Radiology Center, Department of Radiology, NYU Langone Medical Center, New York, USA
AJNR Am J Neuroradiol 33:159-63. 2012..A sizable body of literature describing various experiences with stent-supported coiling now exists. The purpose of this research was to carry out a comprehensive literature survey of stent-supported aneurysm coiling...
- Outcome of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention during on- versus off-hours (a Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] tRoberto J Cubeddu
Aventura Hospital Medical Center, Miami, FL, USA
Am J Cardiol 111:946-54. 2013..We conducted a substudy using the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction study data to determine whether the STEMI arrival time was associated with ..
- Meta-analysis of randomized trials comparing the patency of covered and uncovered self-expandable metal stents for palliation of distal malignant bile duct obstructionAtif Saleem
Department of Internal Medicine, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA
Gastrointest Endosc 74:321-327.e1-3. 2011Self-expandable metal stents (SEMSs) are used for palliation of malignant biliary obstruction.
- Treatment of malignant gastric outlet obstruction with endoscopically placed self-expandable metal stentsJill K J Gaidos
Department of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL 32610, United States
World J Gastroenterol 15:4365-71. 2009..b>Stents can be successfully deployed in the majority of patients...
- No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stentingDirk Sibbing
Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstrasse 36, Munich, Germany
Eur Heart J 32:1605-13. 2011..The aim of this study was to assess the impact of the PON1 Q192R genotype in parallel to that of CYP2C19*2 on the antiplatelet effect of clopidogrel and the risk of ST in clopidogrel-treated patients...
- Coronary stents: a materials perspectiveGopinath Mani
Department of Biomedical Engineering, College of Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249 0619, USA
Biomaterials 28:1689-710. 2007The objective of this review is to describe the suitability of different biomaterials as coronary stents. This review focuses on the following topics: (1) different materials used for stents, (2) surface characteristics that influence ..
- A novel, self-expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: the Wingspan studyArani Bose
Lenox Hill Hospital, New York, NY, USA
Stroke 38:1531-7. 2007....
- Predictive factors of restenosis after coronary implantation of sirolimus- or paclitaxel-eluting stentsAdnan Kastrati
Deutsches Herzzentrum, Technische Universitat, Munich, Germany
Circulation 113:2293-300. 2006The efficacy of drug-eluting stents in reducing restenosis risk has not been uniform across patient subsets. Identifying predictive factors of restenosis may help improve outcomes after percutaneous coronary interventions.
- The evolving role of inflammatory biomarkers in risk assessment after stent implantationGiampaolo Niccoli
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
J Am Coll Cardiol 56:1783-93. 2010The main adverse reactions to coronary stents are in-stent restenosis (ISR) and stent thrombosis. Along with procedural factors, individual susceptibility to these events plays an important role...
- The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stentsAnna Waterhouse
School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
Biomaterials 31:8332-40. 2010Current endovascular stents have sub-optimal biocompatibility reducing their clinical efficacy...
- Drug-eluting versus bare-metal stents in large coronary arteriesChristoph Kaiser
Department of Cardiology, University Hospital, CH 4031 Basel, Switzerland
N Engl J Med 363:2310-9. 2010..are at increased risk for late cardiac events after percutaneous intervention with first-generation drug-eluting stents, as compared with bare-metal stents...
- A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularizationMarie Claude Morice
Institut Cardiovasculaire Paris Sud, Massy, France
N Engl J Med 346:1773-80. 2002..Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris...
- Heparin-bonded covered stents versus bare-metal stents for complex femoropopliteal artery lesions: the randomized VIASTAR trial (Viabahn endoprosthesis with PROPATEN bioactive surface [VIA] versus bare nitinol stent in the treatment of long lesions in supJohannes Lammer
Departments of Cardiovascular and Interventional Radiology, Medical University Vienna, Vienna, Austria Electronic address
J Am Coll Cardiol 62:1320-7. 2013The hypothesis that endovascular treatment with covered stents has equal risks but higher efficacy than bare-metal stents (BMS) in long femoropopliteal artery disease was tested.
- Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomographyDaisuke Matsumoto
Department of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
Eur Heart J 28:961-7. 2007Since the intravascular ultrasound (IVUS) cannot detect neointimal layers in the majority of sirolimus-eluting stents (SES) at the chronic phase, it is still controversial to what extent SES remain uncovered...
- Novel bioabsorbable salicylate-based polymer as a drug-eluting stent coatingRefat Jabara
Saint Joseph s Translational Research Institute, Saint Joseph s Hospital of Atlanta, Atlanta, Georgia 30342, USA
Catheter Cardiovasc Interv 72:186-94. 2008Permanent polymers used in current drug-eluting stents (DES) can trigger chronic inflammation and hypersensitivity reactions, which may contribute to the increased risk of late thrombosis and rebound restenosis...
- Treatment of intracranial aneurysms with the Enterprise stent: a multicenter registryJ Mocco
Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA
J Neurosurg 110:35-9. 2009The development of self-expanding stents dedicated to intracranial use has significantly widened the applicability of endovascular therapy to many intracranial aneurysms that would otherwise have been untreatable by endovascular ..
- Endovascular occlusion of intracranial wide-necked aneurysms with stenting (Neuroform) and coiling: mid-term and long-term resultsJacques Sedat
Unité de Neurointerventionnelle, Hopital St Roch, CHU Nice, 5 rue Pierre Devoluy, Nice, 06000, France
Neuroradiology 51:401-9. 2009Coiling associated with placement of self-expandable intracranial stents has amplified the treatment of intracranial wide-necked aneurysms, but the durability of this treatment and the existence of delayed recurrence are not yet well ..
- First-in-man evaluation of intravascular optical frequency domain imaging (OFDI) of Terumo: a comparison with intravascular ultrasound and quantitative coronary angiographyTakayuki Okamura
Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
EuroIntervention 6:1037-45. 2011..The Terumo-OFDI system is capable of acquiring images with high-speed automated pullback (up to 40 mm/sec) and requires only a short injection (3-4 sec) of small amount of x-ray contrast (9-16 ml)...
- Coronary-artery stentsPatrick W Serruys
Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
N Engl J Med 354:483-95. 2006
- Frequency of complications during EUS-guided drainage of pancreatic fluid collections in 148 consecutive patientsShyam Varadarajulu
Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
J Gastroenterol Hepatol 26:1504-8. 2011..The aim of the present study was to evaluate the frequency of complications during endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFC), identify contributing factors, and report on management outcomes...
- Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trialDavid E Kandzari
Duke Clinical Research Institute, Durham, North Carolina 27705, USA
J Am Coll Cardiol 48:2440-7. 2006This trial examined the relative clinical efficacy, angiographic outcomes, and safety of zotarolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stents (SES).
- Long-term outcome of endovascular reconstruction with the Pipeline embolization device in the management of unruptured dissecting aneurysms of the intracranial vertebral arteryTsz Wai Yeung
Department of Radiology, Tuen Mun Hospital, Tuen Mun, China
J Neurosurg 116:882-7. 2012..The authors report their initial experience with respect to the potential utility and long-term clinical outcomes of using a flow-diverting device in the treatment of unruptured dissecting VA aneurysms...
- Clinical evaluation of a novel lumen-apposing metal stent for endosonography-guided pancreatic pseudocyst and gallbladder drainage (with videos)Takao Itoi
Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan
Gastrointest Endosc 75:870-6. 2012Tubular plastic and metal stents have inherent shortcomings when used for transenteric drainage of fluid collections.
- Do the benefits of metal stents justify the costs? A systematic review and meta-analysis of trials comparing endoscopic stents for malignant biliary obstructionAlan C Moss
Gastrointestinal Unit, Mater Misericordiae University Hospital, Dublin, Ireland
Eur J Gastroenterol Hepatol 19:1119-24. 2007..Although metal stents are associated with longer patency, their costs are significantly higher than plastic stents.
- Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infarction: the importance of thrombus burdenGeorgios Sianos
Erasmus Medical Center, Department of Interventional Cardiology, Thoraxcenter, Rotterdam, The Netherlands
J Am Coll Cardiol 50:573-83. 2007....
- Initial experience with a self-expanding retrievable stent for recanalization of large vessel occlusions in acute ischemic strokeBijoy K Menon
Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
Neuroradiology 54:147-54. 2012..Quicker recanalization results in better clinical outcomes in patients with acute ischemic strokes. We describe our experience with the use of a self-expanding, fully retrievable stent in acute intracranial occlusions...
- Complications in MS patients after CCSVI procedures abroad (Calgary, AB)Jodie M Burton
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Can J Neurol Sci 38:741-6. 2011..Such procedures include angioplasty or stent placement in jugular and azygous veins. The safety and efficacy of these procedures is unknown, but not without risk...
- Temporary placement of fully covered self-expandable metal stents in benign biliary strictures: midterm evaluation (with video)Anshu Mahajan
Digestive Health Center, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
Gastrointest Endosc 70:303-9. 2009Benign biliary strictures (BBS) have been endoscopically managed with placement of multiple plastic stents. Uncovered metal stents have been associated with mucosal hyperplasia and partially covered self-expandable metal stents with ..
- CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control studyAnkie M Harmsze
Department of Clinical Pharmacy, St Antonius Hospital, PO Box 2500, Nieuwegein 3430 EM, The Netherlands
Eur Heart J 31:3046-53. 2010....
- Endovascular treatment options in the management of lower limb deep venous thrombosisSarfraz Ahmed Nazir
Department of Radiology, John Radcliffe Hospital, Headley Way, Oxford, UK
Cardiovasc Intervent Radiol 32:861-76. 2009..This article reviews these technologies and discusses their current role as percutaneous treatment strategies for venous thrombotic conditions...
- Preoperative biliary drainage for cancer of the head of the pancreasNiels A van der Gaag
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
N Engl J Med 362:129-37. 2010..The benefits of preoperative biliary drainage, which was introduced to improve the postoperative outcome in patients with obstructive jaundice caused by a tumor of the pancreatic head, are unclear...
- Carotid artery stents: in vitro comparison of different stent designs and sizes using CT angiography and contrast-enhanced MR angiography at 1.5T and 3TM Lettau
Department of Neurology, University of Heidelberg Medical Center, Heidelberg, Germany
AJNR Am J Neuroradiol 30:1993-7. 2009..5T, and CE-MRA at 3T for the visualization of carotid artery stents and to define the best noninvasive imaging technique as an alternative to conventional angiography for each stent.
- Effectiveness of drug-eluting stents in patients with bare-metal in-stent restenosis: meta-analysis of randomized trialsAlban Dibra
Deutsches Herzzentrum and 1 Medizinische Klinik rechts der Isar, Technische Universitat, Munich, Germany
J Am Coll Cardiol 49:616-23. 2007We sought to synthesize the available evidence on the effectiveness of drug-eluting stents for bare-metal in-stent restenosis.
- Comparative survival of dialysis patients in the United States after coronary angioplasty, coronary artery stenting, and coronary artery bypass surgery and impact of diabetesCharles A Herzog
Cardiovascular Special Studies Center, United States Renal Data System, Minneapolis, Minn, USA
Circulation 106:2207-11. 2002..The optimal method of coronary revascularization in dialysis patients is controversial. The purpose of this study was to compare the long-term survival of dialysis patients in the United States after PTCA, coronary stenting, or CABG...
- Peptides surface modification to prevent stent blockageJoseph Leung; Fiscal Year: 2006..Biliary stents become blocked as a result of bacterial biofilm formation and accumulation of sludge within the lumen of the stent...
- Improved Adventitial Sirolimus Therapy for Peripheral Artery RestenosisKIRK SEWARD; Fiscal Year: 2010..Bare metal stents [5-7] have eliminated elastic recoil and flow-limiting dissections but have not significantly impacted restenosis ..
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2010..Surgical interventions with medical devices such as stents are used for advanced cases...
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2012..Surgical interventions with medical devices such as stents are used for advanced cases...
- Autologous EPC lining to improve biocompatibility of circulatory assist devicesJeffrey H Lawson; Fiscal Year: 2010..could be applicable to other titanium /titanium-alloy blood-contacting surfaces, such as nitinol vascular stents. These could become resistant to in-stent restenosis and benefit millions of Americans who are being treated with ..
- Surgical Indirect Revascularization For Symptomatic Intracranial Aterial StenosisNestor Gonzalez; Fiscal Year: 2013..selection, and use of non-invasive imaging will be useful not only for EDAS evaluation but potentially next generation stents and future novel medical therapies, such as use of angiogenic growth factors and/or endothelial stem cells.
- Clinical center for the study of neuroprotection from PDJoseph Jankovic; Fiscal Year: 2013..As examples, we are currently working with a participant who had had 2 coronary stents placed recently, but we are also coordinating care with his Cardiologist to get a leaky valve replaced in ..
- Synchrotron imaging of crystalline biofilms in urinary cathetersAaron I Packman; Fiscal Year: 2010..in the bladder and kidneys, as well as encrustations on inserted devices such as catheters and ureteral stents. Approximately half of patients with long-term urinary catheters develop catheter blockage as a result of these ..
- Hepatoma derived growth factor and vascular smooth muscle cell proliferationAllen D Everett; Fiscal Year: 2010..in the United States despite interventions with cholesterol lowering agents and the development of endovascular stents. This is because of the continued detrimental growth of vascular cells in the damaged arteries of patients;..
- Thromboresistant Polymers via Catalytic Generation of NOMark E Meyerhoff; Fiscal Year: 2012..significantly reduce the risk of thrombus formation on the surface of polymer coated medical devices, including stents, vascular grafts, implanted catheters and sensors, etc...
- A Novel Electrospun Vascular GraftDavid J Vachon; Fiscal Year: 2010..Often these approaches are combined with stenting. Recent years have seen the development of drug eluting stents (DES) where the metal stent surface is coated with a drug-loaded polymer matrix for sustained release of ..
- EVOLVING MECHANICS OF INTRALUMINAL THROMBUS: FROM FORMATION TO ORGANIZATIONJay D Humphrey; Fiscal Year: 2010..to be one of the limiting concerns in the design and use of many implanted cardiovascular devices, including stents, heart valves, and in-line vascular assist devices...
- Acute Coronary Syndrome Outcomes for Medicare PatientsSALLY STEARNS; Fiscal Year: 2009..syndrome (ACS) is early mechanical myocardial revascularization with either percutaneous intervention with stents (PCIS) or coronary artery bypass grafting (CABG)...
- Novel Polymer Coatings to Prevent Biofilms on Urinary Stents and CathetersJEFFREY LAWRENCE DALSIN; Fiscal Year: 2011DESCRIPTION (provided by applicant): Novel Polymer Coatings to Prevent Biofilms on Urinary Stents and Catheters Bacterial infection and subsequent encrustation of urinary stents and catheters is a persistent problem in clinical urology ..
- Improved Therapeutics for Drug Eluting StentsAlyssa Panitch; Fiscal Year: 2013..Drug-eluting stents (DESs) have been used widely due to their ability to prevent restenosis...
- Development of Porcine Genetic Models of AtherosclerosisSCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2011..Indeed, a consensus report concerning FDA approval of the stents recommends the use of the pig model to assess these devices...
- Commercialization of Tissue Lined Stent Graft for Dialysis Access FailureDON GUSTAVSON; Fiscal Year: 2013..These unique tissue lined stents require special handling in a novel delivery system developed by the company to maintain their physical and ..
- A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial StentsGuillermo A Ameer; Fiscal Year: 2010..This approach will overcome the challenges of bare-metal, drug-eluting, and pre-formed biodegradable stents by being tailored to the contours of the individual artery and coat the entire surface of the artery, thereby ..
- CEREBRAL FUNCTION AFTER HYPOTHERMIC CIRCULATORY ARRESTGabriele DiLuozzo; Fiscal Year: 2012..The first is to find a way to provide flow to the visceral vessels either by devising a simple system for branched stents from the aorta, or by providing flow from the ascending aorta or iliac arteries (extra-anatomic debranching)...
- Exercise, Diabetes, &Coronary Smooth Muscle Ca2+Michael Sturek; Fiscal Year: 2013..Although drug-eluting stents decrease restenosis, further study is needed because of restenosis complications and progression of CAD adjacent ..
- 3D Ultrasound Guidance of Interventional DevicesStephen William Smith; Fiscal Year: 2012..tremendous breakthroughs in the development and application of interventional medical devices including vascular stents, aortic aneurysm stent grafts, vena cava filters, vascular occluders, cardiac occluders, prosthetic cardiac valves,..
- GENE THERAPY WITH SOCS-3 IN INTIMAL HYPERPLASIA AND IN-STENT RESTENOSISDevendra K Agrawal; Fiscal Year: 2013..Drug-eluting stents cause less intimal hyperplasia and less late luminal loss, but inhibit re- endothelialization of the stented ..
- Novel Biological Tissue Lined Vascular Stent Crimping and Delivery SystemMICHAEL JOHN WIGGINS; Fiscal Year: 2010..Despite enthusiasm for drug-coated stents and atherectomy devices, there is no ideal endovascular solution to treating lower extremity occlusive disease, as ..
- Stents and Antiplatelet Drugs: Impact on Ischemia and Bleeding in the ElderlySamip Vasaiwala; Fiscal Year: 2011..In general, there are two types of coronary stents: drug-coated (or drug-eluting stents, DES) and non-drug- coated (or bare metal stents, BMS)...
- Prolonged Clopidogrel Use After Drug-Eluting and Bare-Metal Coronary StentingScott Kinlay; Fiscal Year: 2013..Our primary aim is to assess the risk of death or myocardial infarction by type of coronary stent (bare-metal stents, 1st generation drug-eluting stents, and 2nd generation drug-eluting stents...
- MESENCHYMAL STEM CELLS IN THE PREVENTION OF THROMBOSIS AND NEOINTIMAL HYPERPLASIADevendra K Agrawal; Fiscal Year: 2013DESCRIPTION (provided by applicant): Drug-eluting stents cause less intimal hyperplasia and less late luminal loss, but inhibit re- endothelialization of the stented segment making it more susceptible to thrombosis...
- Translational Model Development: Rapamycin, Aging, and Endothelial DysfunctionDean L Kellogg; Fiscal Year: 2013..Clinical studies find that RAPA eluting stents induce endothelial dysfunction and increase in-stent thrombosis risk in humans...
- Caregiver Responses to Nasoalveolar Molding and Early Cleft CareHillary L Broder; Fiscal Year: 2013..to reduce the severity of initial cleft deformity through the use of surgical tape, molding plates, and nasal stents. It has polarized professionals in the field of craniofacial habilitation because of the additional demands NAM ..
- Regulation of Vascular Smooth Muscle Cell ProliferationHana Totary Jain; Fiscal Year: 2010..Drug-eluting stents (rapamycin-sirolimus) was a major advance in the treatment of CAD, causing significant reduction in the incidence ..
- Phase 2/3 of Covered Cheatham Platinum Stent for Aortic Wall InjuryRICHARD ELLIOT RINGEL; Fiscal Year: 2013..In the US and Europe, catheter-delivered balloon expandable stents have become the predominant therapy for CoA recurrence and new diagnoses of CoA in this age group;however, there ..
- Endovascular device and treatment for stabilizing aortic aneurysmsMATTHEW FRANK OGLE; Fiscal Year: 2010..Although often effective, endovascular stents are anatomically appropriate for only 30% to 60% of AAA patients at the outset and present the risk of endoleaks ..
- Regulatory Advancement of HXe as a Diagnostic MRI Contrast AgentIULIAN CONSTANTIN RUSET; Fiscal Year: 2013DESCRIPTION (provided by applicant): New therapies are in development for COPD (endobronchial valves/stents/glue) and asthma (endobronchial thermal ablation)...
- Improved stent design through hemodynamics and vascular biologyJuan Miguel Jimenez; Fiscal Year: 2013..The candidate is a trained fluid dynamics engineer who is addressing blood flow interactions with coronary stents. He will transition to experimental cardiovascular biomedicine under the "Mentored Quantitative Research ..
- Efficiencies for Outcome Ascertainment throughout the Total Product Life CycleJ Matthew Brennan; Fiscal Year: 2013..Existing predicates using procedure-oriented national registries for evaluation of coronary stents, defibrillators and prosthetic heart valves already demonstrate efficiencies with high impact potential for device ..
- EVALUATION OF ENDOBRONCHIAL INTERVENTIONS FOR COPD VIA CT AND 3HE MRIJason C Woods; Fiscal Year: 2011..to demonstrate the utility of pulmonary imaging techniques to (i) guide the endoscopic installation of valves or stents in a given lung and (ii) predict the functional improvement outcomes for a given intervention...
- Improved Adventitial Rapamycin Therapy for Peripheral Artery RestenosisKIRK SEWARD; Fiscal Year: 2013..Bare metal stents [5-7] have eliminated elastic recoil and flow-limiting dissections bu have not significantly impacted restenosis ..
- Instrumentation for Creating Biological Stents and OcclusionsFRED STERZER; Fiscal Year: 2011..in an animal model of minimally invasive microwave balloon catheter instrumentation for producing biological stents in pancreatic ducts and bile ducts and for producing biological occlusions in blood vessels of the liver...
- Regulation of nitrogen catabolic gene expression in S. cerevisiaeTerrance G Cooper; Fiscal Year: 2013..the coagulation cascade) has raised high concern about late stent thrombosis in rapamycin-derivative eluting stents used to treat acute myocardial infarction...
- Host immune response to E. faecalis bioflimNathan Shankar; Fiscal Year: 2011..infections by Enterococcus faecalis, especially those associated with intravascular catheters, biliary stents and other implants have increased dramatically in recent years...
- Improving the Outcomes of Hemodialysis Arteriovenous GraftsIvan D Maya; Fiscal Year: 2010..Deployment of stents at the stenotic sites may improve these outcomes by delaying restenosis...
- Comparative Effectiveness of Coronary StentsEdward Hannan; Fiscal Year: 2013..million percutaneous coronary interventions (PCIs) in 2009, the vast majority of which are performed with coronary stents. They also consume a substantial portion of our country's health expenditures, with an estimated $68 billion ..
- A Novel Thin Film Nitinol Covered Stent to Treat Peripheral Arterial DiseaseDavid A Rigberg; Fiscal Year: 2010..Bulk Nitinol is found in many medical devices including most notably stents. Despite being inert due to its titanium oxide layer, thrombosis occurs due to bulk Nitinol's surface ..
- Magnetic Targeting Of Stents With Endothelial Cells For Prevention Of RestenosisBoris Polyak; Fiscal Year: 2013..by applicant): For the past decade the advent of stent angioplasty and the even more recent use of drug eluting stents have resulted in a paradigm shift in the care of vascular disease...
- Technology Diffusion, Health Outcomes, and Healthcare ExpendituresJonathan S Skinner; Fiscal Year: 2013..The proposal considers two specific treatments: the sharp reduction in carotid endarterectomy (both surgery and stents), and the decline in the use of Rosiglitazone (Avandia), an anti-diabetic drug, following a 2007 publication ..
- Molecular Targeted, Focused, Ultrasound-Based Delivery of Antiproliferative DrugsJohn A Hossack; Fiscal Year: 2012..To address this, several major medical device companies have developed stents that release anti-proliferative agents to prevent restenosis and are currently on the US market...
- Measuring the effect of extracellular mechanics on smooth muscle contractilityPatrick W Alford; Fiscal Year: 2013..a significant role in its functional behavior, suggesting that non-homeostatic tissue mechanics, due to plaques or stents, could also affect contractile function...
- Gene Delivery StentsRobert J Levy; Fiscal Year: 2013..Our group has pioneered the concept that an even greater therapeutic benefit than possible with current bare metal stents (BMS) or drug eluting stents (DES) could be achieved with stent-mediated gene therapy from the bare metal surfaces ..
- An Enabling Technology for Improving Engraftment of Implanted Materials and CellsMichael J Yost; Fiscal Year: 2013..include disfigurement of silicone prostheses and loss of function of devices such as implanted pacemakers, stents, and shunts...
- Intrabiliary MR/RF-enhanced chemotherapy of malignant biliary obstructionsXiaoming Yang; Fiscal Year: 2013..However, the short term durability of biliary stents necessitates repeated interventions and longer hospital stays with associated high economic burden...
- mTOR Signaling and Vascular Repair in an Experimental Model of Diabetes MellitusALOKE VIRMANI FINN; Fiscal Year: 2013..therapies have created a serious disconnect between the eagerness to use new medical devices such as drug eluting stents (DES) in combination with diabetic therapies such as PPAR3 agonists on the one hand and the understanding of how ..
- Electropolishing of Nitinol Stents in Aqueous, Acid Free SolutionsMARIA E INMAN; Fiscal Year: 2013..proposes to develop the FARADAYIC ElectroPolishing Process, based on pulse reverse electrolytic polishing of stents, fabricated from nitinol and other materials of interest to industry, for rapid, cost-effective surface finishing ..
- Endothelial Progenitor Cell Seeded Self-Expanding Vascular StentHARDEAN ERIC ACHNECK; Fiscal Year: 2012..by applicant): Objectives: It is the goal of this study to develop a technology to line self-expanding Nitinol stents with autologous peripheral blood-derived endothelial progenitor cells (EPCs) in order to reduce the common and ..
- Hormones and Sexual Function Predict Outcomes in Revascularized Men with DiabetesMARY A MCLAUGHLIN; Fiscal Year: 2013..trial comparing revascularization with either coronary artery bypass graft surgery (CABG) or with drug eluting stents in 2,400 patients with DM and multi-vessel CAD...
- Development of a second generation intra-sacular cerebral aneurysm flow diverterWILLIAM ROBERT PATTERSON; Fiscal Year: 2011..Current "flow diverters" are constructed of braided tubular structures, similar in character to endovascular stents but with markedly higher metallic coverage across the neck as compared to standard stents...
- Layer by layer assembly for making drug-eluting stentsKinam Park; Fiscal Year: 2009Project Description Drug-eluting stents (DESs) have been used widely because of their ability to prevent restenosis...
- Vascular endoluminal cellular paving using acoustic radiation forceCatalin Toma; Fiscal Year: 2013ABSTRACT Coronary stents represent an important tool in the armamentarium available to treat symptomatic atherosclerotic plaques, with over 1 million procedures performed annually in the US alone...
- Mitigation of stent-mediated pathology by streamlined geometryPeter Francis Davies; Fiscal Year: 2010DESCRIPTION (provided by applicant): Drug-eluting stents (DES) are deployed to physically reopen stenotic regions of coronary arteries to restore blood flow to the heart and to inhibit restenosis by release of anti-proliferative drugs ..
- ProHealing Drug Alternative for Coronary Drug Eluting StentsPATRICK SL WONG; Fiscal Year: 2012DESCRIPTION (provided by applicant): ProHealing Drug Alternative for Coronary Drug Eluting Stents Our goal is to develop a novel, safer and more efficacious approach for treating Coronary Artery Disease, by incorporating a modulator of ..
- Physician Level Analysis of Medical Technology Diffusion: Coronary Stents StudyPinar Karaca-Mandic; Fiscal Year: 2013..I propose to study the diffusion of medical technology using coronary artery stents in the Medicare population as the exemplar...
- Self-microencapsulation in polymer delivery systems without organic solventsSteven P Schwendeman; Fiscal Year: 2010..configurations and geometries such as microspheres, nanospheres, tissue engineering scaffolds, drug-eluting stents, and d) could be performed by clinicians and investigators in the field, since encapsulation is by simple aseptic ..
- COMPARATIVE EFFECTIVENESS OF CARDIOVASCULAR DEVICES AND MEDICARE COST GROWTHPeter W Groeneveld; Fiscal Year: 2011..program, and recent Centers for Medicare and Medicaid Services coverage decisions for drug-eluting coronary stents (2003) and carotid arterial stents (2004), as well as expansions of coverage indications for implantable ..
- ElectroPolishing for Cost Effective, High Yield Nitinol Stent FabricationMARIA E INMAN; Fiscal Year: 2013..proposes to develop the FARADAYIC [ElectroPolishing Process, based on pulse reverse electrolytic polishing of stents, fabricated from nitinol and other materials of interest to industry, for rapid, cost-effective surfce finishing] ..
- Radioactive Stents for Brachytherapy of Esophageal CancersYONGREN BENJAMIN PENG; Fiscal Year: 2013..have formed a critical cluster of interdisciplinary experts for the development of advanced radioactive esophageal stents that will maximize dose to the tumors and significantly shorten the dose delivery time to more quickly achieve ..
- Study of TTP: Incidence Rates and Risk FactorsCharles Bennett; Fiscal Year: 2005..therapy with commonly used antiplatelet drugs or following commonplace interventional procedures such as arterial stents. As with other rare diseases, there are significant gaps in the understanding of the pathogenesis of TTP, its ..
- Prevention of neointimal thickening by Mst1Junichi Sadoshima; Fiscal Year: 2006..provided by applicant): In-stent restenosis remains an unsolved clinical problem in the era of drug-eluting stents (DES)...
- COATING OF URINARY PROTHESES TO PREVENT ENCRUSTATIONHarmeet Sidhu; Fiscal Year: 2000Prosthetic stents and in-dwelling catheters are frequently used in urological and nephrological medicine for the management of urinary and peritoneal dialysis flow, haemodialysis, and drainage of renal calculi following laser or ..
- Elastic biodegradable ureteral stentHaesun Park; Fiscal Year: 2009The objective of this Phase I study is to develop elastic, biodegradable ureteral stents that will degrade in the body within 2 weeks after a procedure...
- Drug-eluting Tracheobronchial Stents to treat Obstruction caused by Lung CancerNarmada Shenoy; Fiscal Year: 2007..The specific objectives of this proposal are: 1. Develop preclinical animal-stents to enable proof-of-concept drug uptake and distribution studies in rats. 2...
- Iodine-125 Peripheral Intravascular Brachytherapy SystemJohn Munro; Fiscal Year: 2004..None of these have been successful. Nor have the recent success surrounding the use of drug-eluting stents in the coronary vascular system yet been translated to the peripheral vascular system...
- PET/CT for Multidimensional Translational Cardiovascular ResearchJOHN CANTY; Fiscal Year: 2009..Besides basic mechanistic research, active programs exist in therapeutics including vascular stents, in vivo gene transfer and cardiovascular repair with stem cells (mesenchymal stem cells and endothelial ..
- Study of design variables of the endovascular graftMADHAVAN RAGHAVAN; Fiscal Year: 2007..In endovascular repair, the endovascular graft (EVG) - a vascular graft covered by stents - is passed through a femoral artery to the aneurysm...
- Ribonucleotide Reductase Inhibitors for RestenosisHoward Elford; Fiscal Year: 2009..However, the increased incidence of thrombosis observed in a number of clinical trials examining drug eluting stents (DES), have made thrombosis a critical issue in the use of these devices...
- ENZYME-COATED URINARY PROSTHESES TO PREVENT ENCRUSTATIONSTEPHEN BARTELMEZ; Fiscal Year: 2004Use of indwelling catheters and stents long-term in the urinary tract is often limited due to the occurrence of encrustation and biofilm formation To date, there are no biomaterials used in the urinary tract that are completely ..
- Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem CellsSTEPHEN BARTELMEZ; Fiscal Year: 2009..Furthermore, current cellular therapies as well as mechanical therapies such as stents may not benefit this at risk population because of high TGF-21 levels, which can lead to CD34+/EPC dysfunction...
- Disposable Valved Intraurethral Catheter FeasibilityPhillip Davis; Fiscal Year: 2005..The stents will bridge the urethral sphincters from bladder neck to bulbous urethra...
- Quantifying altered hemodynamics in response to stenting for aortic coarctationJOHN LADISA; Fiscal Year: 2009..b>Stents are permanent metal scaffolds that can be implanted during a minimally-invasive procedure to restore blood flow ..
- Novel A2A Adenosine Agonists in Vascular ProtectionJayson Rieger; Fiscal Year: 2005..Aim 1 proposes to investigate the elution kinetics of ATL146e and rolipram from stents into blood in vitro...
- PREVENTION OF BIOFILMS IN MEDICAL DEVICESBhami Shenoy; Fiscal Year: 2003..against biofilm formation on medical devices /implants such as urethral catheters, ureteric and prostatic stents, penile and testicular implants, artificial urinary sphincters, prostheses for hip and knee replacements, shunts ..
- Continuous Biofilm Disrupting MaterialsSHANTHA SARANGAPANI; Fiscal Year: 2009..Most medical devices such as vascular and other catheters and non-vascular stents are made of thermoplastic medical grade polymers such as polyurethanes...
- Implications of cardiovascular technology diffusion among Medicare beneficiariesPETER GROENEVELD; Fiscal Year: 2009DESCRIPTION (provided by applicant): Recent Food and Drug Administration approvals of drug-eluting coronary stents (2003) and carotid arterial stents (2004), as well as the expansions of coverage indications for implantable cardioverter- ..
- ZYNPEPTIDES AS MODULATORS OF RESPONSES TO BIOMATERIALSGregory Kopia; Fiscal Year: 1991Intravascular stents are spring-like devices which are placed in atherosclerotic human coronary and iliac arteries to keep them from collapsing after balloon angioplasty...
- Cell-Selective Liposomal Drug Delivery In RestenosisRoger Marchant; Fiscal Year: 2005..to inhibit neointima formation through pharmacological intervention and the use of surface-modified intracoronary stents. The overall goal of the proposed research is to bioengineer new liposome drug delivery systems that selectively ..
- PERIPHERAL STENTS WITH ION IMPLANTED RADIOACTIVITYANTHONY ARMINI; Fiscal Year: 2000..Irradiation has heretofore never been applied to peripheral stents. Using an existing ion implanter to deliver ytterbium-169, a gamma emitter, to the stents, animal testing is ..
- NOVEL APPROACH TO TIPS: STENT POLYMER PAVING COMPOSITESM Panahandeh; Fiscal Year: 2001..non-surgical approach of portal decompression was made possible through the clinical introduction of vascular stents. At first, balloon expandable stents, such as Palmaz stents or Tantalum Strecker stents were employed in TIPS ..