heart valve prosthesis

Summary

Summary: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.

Top Publications

  1. ncbi Indication of cavitation in mechanical heart valve patients
    Tina S Andersen
    Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital Skejby Sygehus, Denmark
    J Heart Valve Dis 12:790-6. 2003
  2. ncbi Late incidence and determinants of reoperation in patients with prosthetic heart valves
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont, Canada K1Y 4W7
    Eur J Cardiothorac Surg 25:364-70. 2004
  3. ncbi Elderly valve replacement with bioprostheses and mechanical prostheses. Comparison by composites of complications
    S A Suttie
    University of British Columbia, Vancouver, Canada
    J Cardiovasc Surg (Torino) 47:191-9. 2006
  4. ncbi Patient-prosthesis mismatch: the Japanese experience
    Kazuhiro Hashimoto
    Department of Cardiovascular Surgery, Jikei University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 12:159-65. 2006
  5. ncbi Evidence of mitigated calcification of the Mosaic versus Hancock Standard valve xenograft in the mitral position of young sheep
    Patricia A Weber
    International Heart Institute of Montana Foundation at Saint Patrick Hospital and Health Sciences Center and The University of Montana, Missoula, Mont, USA
    J Thorac Cardiovasc Surg 132:1137-43. 2006
  6. ncbi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
  7. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
  8. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, , Paris, France
    Eur Heart J 28:230-68. 2007
  9. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
  10. ncbi Choice of prosthetic heart valve for adult patients
    Shahbudin H Rahimtoola
    Griffith Center, Division of Cardiovascular Medicine, Department of Medicine, LAC + USC Medical Center, Keck School of Medicine at the University of Southern California, 2025 Zonal Avenue, Los Angeles, CA 90033, USA
    J Am Coll Cardiol 41:893-904. 2003

Research Grants

  1. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2003
  2. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2007
  3. DENTIN BIOMINERALIZATION
    Charles Sfeir; Fiscal Year: 2007
  4. Training in Biomechanics in Regenerative Medicine
    Michael Sacks; Fiscal Year: 2007
  5. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2009
  6. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael Sacks; Fiscal Year: 2007
  7. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2007
  8. Biomechanical optimization of TE heart valves
    Michael S Sacks; Fiscal Year: 2010
  9. Biomechanical optimization of TE heart valves
    Michael Sacks; Fiscal Year: 2007
  10. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael S Sacks; Fiscal Year: 2010

Detail Information

Publications189 found, 100 shown here

  1. ncbi Indication of cavitation in mechanical heart valve patients
    Tina S Andersen
    Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital Skejby Sygehus, Denmark
    J Heart Valve Dis 12:790-6. 2003
    ..This indication of cavitation was not observed in patients with either native or bioprosthetic aortic valves...
  2. ncbi Late incidence and determinants of reoperation in patients with prosthetic heart valves
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont, Canada K1Y 4W7
    Eur J Cardiothorac Surg 25:364-70. 2004
    ..With a focus on bioprosthetic valves, this study examines risk factors for reoperation in a large patient cohort...
  3. ncbi Elderly valve replacement with bioprostheses and mechanical prostheses. Comparison by composites of complications
    S A Suttie
    University of British Columbia, Vancouver, Canada
    J Cardiovasc Surg (Torino) 47:191-9. 2006
    ..Overall actual and actuarial freedom from valve related reoperation at 15 years was 95.8+/-1.6% and 74.8+/-16.9%, respectively. CONCLUSIONS: BP valves are further confirmed to be a good option for AVR in patients = or >75 years of age...
  4. ncbi Patient-prosthesis mismatch: the Japanese experience
    Kazuhiro Hashimoto
    Department of Cardiovascular Surgery, Jikei University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 12:159-65. 2006
    ..We discuss our present strategy after the introduction of a new high performance prosthesis, since the EOAs are dramatically increased...
  5. ncbi Evidence of mitigated calcification of the Mosaic versus Hancock Standard valve xenograft in the mitral position of young sheep
    Patricia A Weber
    International Heart Institute of Montana Foundation at Saint Patrick Hospital and Health Sciences Center and The University of Montana, Missoula, Mont, USA
    J Thorac Cardiovasc Surg 132:1137-43. 2006
    ..A longer durability is expected with the clinical use of the Mosaic porcine valve...
  6. ncbi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
    ..The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008...
  7. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  8. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, , Paris, France
    Eur Heart J 28:230-68. 2007
  9. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported...
  10. ncbi Choice of prosthetic heart valve for adult patients
    Shahbudin H Rahimtoola
    Griffith Center, Division of Cardiovascular Medicine, Department of Medicine, LAC + USC Medical Center, Keck School of Medicine at the University of Southern California, 2025 Zonal Avenue, Los Angeles, CA 90033, USA
    J Am Coll Cardiol 41:893-904. 2003
    ..In individual patients there may be exceptions to these general rules...
  11. ncbi Comparison of multidetector-row computed tomography to echocardiography and fluoroscopy for evaluation of patients with mechanical prosthetic valve obstruction
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken, Zwolle, The Netherlands
    Am J Cardiol 104:1128-34. 2009
    ..In conclusion, this initial experience demonstrates that multidetector-row computed tomography can identify causes of prosthetic valve obstruction that constitute indications for surgery but are missed at echocardiography or fluoroscopy...
  12. ncbi Long-term outcomes after isolated aortic valve replacement in octogenarians: a modern perspective
    Vinod H Thourani
    Clinical Research Unit, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 86:1458-64; discussion 1464-5. 2008
    ..This study compares the short- and long-term survival outcomes of octogenarians after AVR with younger age groups in the modern surgical era...
  13. ncbi Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, , , Canada
    J Thorac Cardiovasc Surg 132:401-6. 2006
    ..Because of the fast onset of symptoms with leaflet tear, patients with a Freestyle stentless bioprosthesis should be informed of the preferential mode of failure and time-frame of symptoms...
  14. ncbi Guidelines for reporting mortality and morbidity after cardiac valve interventions
    Cary W Akins
    The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 85:1490-5. 2008
  15. ncbi The role of ECG-gated MDCT in the evaluation of aortic and mitral mechanical valves: initial experience
    Eli Konen
    Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
    AJR Am J Roentgenol 191:26-31. 2008
    ..The objective of our study was to evaluate the role of ECG-gated MDCT in the functional evaluation of mechanical prosthetic aortic and mitral valves...
  16. ncbi Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Res 108:3-13. 2002
    ..The objectives of this review are to focus on practical issues relating to perioperative anticoagulation and the implementation of a perioperative anticoagulation management approach that can be used in everyday clinical practice...
  17. ncbi Early conduction disorders following percutaneous aortic valve replacement
    Valeria Calvi
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Pacing Clin Electrophysiol 32:S126-30. 2009
    ..We examined the incidence and characteristics of CD in the immediate postoperative period after PAVR, and the need for permanent pacemaker (PPM) implantation...
  18. ncbi Deleterious outcome of No-React-treated stentless valved conduits after aortic root replacement: why were warnings ignored?
    Thierry P Carrel
    Department of Cardiovascular Surgery, University Hospital, Berne, Switzerland
    J Thorac Cardiovasc Surg 136:52-7. 2008
    ....
  19. ncbi Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard
    I Chen Tsai
    Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Eur Radiol 19:857-67. 2009
    ..Except for images impaired by severe beam-hardening artifacts, MDCT provides excellent delineation of prosthetic valve disorders...
  20. ncbi Progress and current status of percutaneous aortic valve replacement: results of three device generations of the CoreValve Revalving system
    Eberhard Grube
    Departments of Cardiology, Cardiac Surgery, and Anaesthesiology, HELIOS Heart Center Siegburg, Ringstrasse 49, Siegburg, Germany
    Circ Cardiovasc Interv 1:167-75. 2008
    ..This study was intended to provide a summary of the development and current safety and efficacy status of the self-expanding CoreValve Revalving prosthesis...
  21. ncbi Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN prosthesis: incidence and impact on outcome
    Gregory Ducrocq
    Department of Cardiology, Bichat Claude Bernard Hospital, Paris, France
    EuroIntervention 5:666-72. 2010
    ..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...
  22. ncbi Unexpected complications of transapical aortic valve implantation
    Nawwar Al-Attar
    Department of Cardiovascular Surgery, Bichat Claude Bernard Hospital, Paris, France
    Ann Thorac Surg 88:90-4. 2009
    ..However, specific problems of this new procedure are not well-described. Unexpected complications due to the procedure and their management are reported...
  23. ncbi Vascular complications with transcatheter aortic valve implantation using the 18 Fr Medtronic CoreValve System: the Rotterdam experience
    Nicolas M Van Mieghem
    Department of Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands
    EuroIntervention 5:673-9. 2010
    ..Access site complications, therefore, can be a concern. The aim of this study is to present the 30-day incidence of major and minor vascular complications in patients treated with the third generation 18 Fr Medtronic CoreValve System...
  24. ncbi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry...
  25. ncbi Treatment of destructive aortic valve endocarditis with the Freestyle Aortic Root Bioprosthesis
    Ludwig C Müller
    Department of Cardiac Surgery, University of Innsbruck, Innsbruck, Austria
    Ann Thorac Surg 75:453-6. 2003
    ..Homograft aortic roots are the conduits of choice, but because they are not available in all cases, alternative conduits are needed...
  26. ncbi Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II6-10. 1999
    ..The aim of this prospectively randomized study was to evaluate left ventricular hypertrophy and its regression after stentless versus conventional biological aortic valve replacement...
  27. ncbi United States feasibility study of transcatheter insertion of a stented aortic valve by the left ventricular apex
    Lars G Svensson
    Center for Aortic Surgery, Marfan Syndrome and Connective Tissue Disorders Clinic, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Thorac Surg 86:46-54; discussion 54-5. 2008
    ..We report on a Food and Drug Administration approved feasibility study of a less invasive transcatheter approach to potentially treat these high-risk patients...
  28. ncbi Transapical minimally invasive aortic valve implantation; the initial 50 patients
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Eur J Cardiothorac Surg 33:983-8. 2008
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  29. ncbi Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography
    A Ionescu
    University of Wales College of Medicine, Cardiff, UK
    Heart 89:1316-21. 2003
    ..To assess the prevalence, mechanisms, and significance of paraprosthetic regurgitation detected incidentally by transoesophageal echocardiography (TOE) in patients after heart valve replacement...
  30. ncbi Staphylococcus lugdunensis infective endocarditis: description of 10 cases and analysis of native valve, prosthetic valve, and pacemaker lead endocarditis clinical profiles
    I Anguera
    Department of Cardiology, , Hospital de Sabadell, Sabadell, Spain
    Heart 91:e10. 2005
    ..Surgery has improved survival in left sided IE and, therefore, early surgery should always be considered. Prosthetic valve S lugdunensis IE carries an ominous prognosis...
  31. ncbi Thrombolytic therapy for prosthetic valve thrombosis in children: two case reports and review of the literature
    Brian Kogon
    Emory University, Egleston Hospital, Children's Healthcare of Atlanta, Department of Pediatric Cardiothoracic Surgery, GA 30306, USA
    J Thorac Cardiovasc Surg 127:1519-22. 2004
  32. ncbi Atrioventricular block after transcatheter balloon expandable aortic valve implantation
    Ajay Sinhal
    Heart Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    JACC Cardiovasc Interv 1:305-9. 2008
    ..Transcatheter aortic valve replacement (AVR) is a promising approach to aortic valve disease. The implications of this new therapy are not entirely known. We describe the potential for the development of new atrioventricular (AV) block...
  33. ncbi Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve
    Nicolo Piazza
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    JACC Cardiovasc Interv 1:310-6. 2008
    ..In this retrospective study, we examined the incidence of post-procedural conduction abnormalities and the need for pacing in patients undergoing percutaneous implantation of the aortic valve...
  34. ncbi Postoperative coronary artery spasm complicating aortic valve replacement: implications for identification and treatment
    Claudio Pragliola
    Institute of Cardiac Surgery, Catholic University of Rome, Rome, Italy
    Ann Thorac Surg 83:670-2. 2007
    ..The spasm was demonstrated at coronary angiography and was resolved with the intracoronary infusion of nitrates and antiarrhythmics...
  35. ncbi Predictors for permanent pacemaker requirement after transcatheter aortic valve implantation with the CoreValve bioprosthesis
    Hasan Jilaihawi
    Glenfield Hospital, Leicester, United Kingdom
    Am Heart J 157:860-6. 2009
    ..We hypothesized that the need for PPM after CoreValve (Corevalve Inc, Irvine, CA) can be predicted with a combination of baseline variables...
  36. ncbi In-vivo prediction of cavitation near a Medtronic Hall valve
    Peter Johansen
    Department of Cardiothoracic and Vascular Surgery and Institute of Experimental Clinical Research, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark
    J Heart Valve Dis 13:651-8. 2004
    ....
  37. ncbi The subcoronary Toronto stentless versus supra-annular Perimount stented replacement aortic valve: early clinical and hemodynamic results of a randomized comparison in 160 patients
    John B Chambers
    Valve Study Group, St Thomas Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 131:878-2. 2006
    ..The aim of this study was to compare early postoperative hemodynamic function and clinical events in a randomized, prospective series of 160 stentless and stented biological replacement aortic valves...
  38. ncbi Cerebrovascular events after stentless aortic valve replacement during a 9-year follow-up period
    Helmut Gulbins
    Department of Cardiac Surgery, Heart Institute Lahr, Institute of Cardiovascular Medicine, University Witten Herdecke, Hamburg, Germany
    Ann Thorac Surg 86:769-73. 2008
    ..The purpose of this study was to evaluate the incidence of cerebrovascular events during long-term follow-up after stentless aortic valve replacement...
  39. ncbi Factors influencing calcification of cardiac bioprostheses in adolescent sheep
    Willem Flameng
    Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    J Thorac Cardiovasc Surg 132:89-98. 2006
    ..We determined the possible effects of age, antimineralization treatments, circulatory implant conditions, prosthesis design, and valve-related structural aspects on valve calcification in adolescent sheep...
  40. ncbi Long-term results after aortic valve replacement with the Bravo 400 stentless xenograft
    GianLuca Polvani
    Department of Cardiac Surgery and Cardiology, University of Milan, Centro Cardiologico Monzino IRCCS, Milan, Italy
    Ann Thorac Surg 80:495-501. 2005
    ..Left ventricular mass index at 10-year follow-up was 68.5% of the preoperative value. CONCLUSIONS: The Bravo Cardiovascular Model 400 stentless xenograft has provided good clinical and hemodynamic results up until 11 years of follow-up...
  41. ncbi Are stentless valves superior to modern stented valves? A prospective randomized trial
    Ayyaz Ali
    Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, Cambridge, CB3 8RE, UK
    Circulation 114:I535-40. 2006
    ..It is presumed that stentless aortic bioprostheses are hemodynamically superior to stented bioprostheses. A prospective randomized controlled trial was undertaken to compare stentless versus modern stented valves...
  42. ncbi Mechanical heart valve cavitation
    Peter Johansen
    Department of Cardiothoracic and Vascular Surgery, Research Unit, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Expert Rev Med Devices 1:95-104. 2004
    ..Therefore, an applicable technique for in vivo detection of cavitation is required. This article reviews techniques developed for in vivo detection of cavitation and suggests focus for future studies...
  43. ncbi First percutaneous transcatheter aortic valve-in-valve implant with three year follow-up
    Carlos E Ruiz
    Department of Cardiac and Vascular Interventional Services, Lenox Hill Heart and Vascular Institute of New York, New York, USA
    Catheter Cardiovasc Interv 72:143-8. 2008
    ..This study was conducted to report the clinical, hemodynamic, and iconographic outcomes of the longest survivor of the global CoreValve experience...
  44. ncbi Implantation of two self-expanding aortic bioprosthetic valves during the same procedure-Insights into valve-in-valve implantation ("Russian doll concept")
    Nicolo Piazza
    Interventional Cardiology Department, Erasmus MC, Thoraxcenter, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 73:530-9. 2009
    ..We discuss also the potential valve of on-line quantitative angiography for assessing the depth of valve implantation and the need to implant a second valve...
  45. ncbi Prognostic significance of newly acquired bundle branch block after aortic valve replacement
    Ziad El-Khally
    Department of Cardiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Am J Cardiol 94:1008-11. 2004
    ..A new and persistent BBB acquired after AVR is associated with an increased adverse event rate. This finding suggests that early prophylactic pacemaker implantation should be considered in these patients...
  46. ncbi Calcification of tissue heart valve substitutes: progress toward understanding and prevention
    Frederick J Schoen
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, The Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 79:1072-80. 2005
    ....
  47. ncbi Are allografts the biologic valve of choice for aortic valve replacement in nonelderly patients? Comparison of explantation for structural valve deterioration of allograft and pericardial prostheses
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:558-564.e4. 2006
    ..To compare explantation for structural valve deterioration in nonelderly patients after aortic valve replacement with stented bovine pericardial and cryopreserved allograft valves...
  48. ncbi A new approach to detection of the cavitation on mechanical heart valves
    Koki Takiura
    Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    ASAIO J 49:304-8. 2003
    ....
  49. ncbi Stentless aortic valves as an alternative to homografts for valve replacement in active infective endocarditis complicated by ring abscess
    Henryk Siniawski
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 75:803-8; discussion 808. 2003
    ..To avoid implantation of any prosthetic material, the Shelhigh No-React stentless valves and conduits may be considered an alternative when no suitable homograft is available...
  50. ncbi Aortic valve disease with severe ventricular dysfunction: stentless valve for better recovery
    Stefano Bevilacqua
    Institute of Clinical Physiology, Cardiac Surgery Department, Massa, Italy
    Ann Thorac Surg 74:2016-21. 2002
    ..The aim of this retrospective study was to assess the potential benefits of stentless aortic valve implantation for patients undergoing isolated aortic valve replacement with left ventricular ejection fraction < or = 35%...
  51. ncbi Replacing the ascending aorta and aortic valve for acute prosthetic valve endocarditis: is using prosthetic material contraindicated?
    Christian Hagl
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York, USA
    Ann Thorac Surg 74:S1781-5; discussion S1792-9. 2002
    ..We report favorable results using this technique almost exclusively (a homograft was used in only 3 patients with hematological problems) during a 12-year interval...
  52. ncbi Replacement of the systemic atrioventricular valve with a mechanical prosthesis in children aged less than 6 years: late clinical results of survival and subsequent replacement
    Kilian Ackermann
    Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University Munich, Munich, Germany
    J Thorac Cardiovasc Surg 134:750-6. 2007
    ..We analyzed the survival, clinical course, and role of prosthesis-patient mismatch after systemic atrioventricular valve replacement in children...
  53. ncbi Transcatheter aortic valve prosthesis surgically replaced 4 months after implantation
    Hans Gustav Thyregod
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Eur J Cardiothorac Surg 37:494-6. 2010
    ..We report the first case of surgical valve replacement in a patient with a dysfunctional transcatheter-implanted aortic valve prosthesis 4 months after implantation...
  54. ncbi Spectral characteristics of mechanical heart valve closing sounds
    Peter Johansen
    Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital Skejby Sygehus, Denmark
    J Heart Valve Dis 11:736-44. 2002
    ..This might provide the information needed to design the optimal high-pass filter when evaluating cavitation...
  55. ncbi Effect of valve suture technique on incidence of paraprosthetic regurgitation and 10-year survival
    Sukumaran K Nair
    Department of Cardiothoracic Surgery, St George s Hospital NHS Trust, London, United Kingdom
    Ann Thorac Surg 89:1171-9. 2010
    ..The secondary objective was to estimate the risk of redo valve surgery and 10-year survival after valve replacement performed using either suture technique...
  56. ncbi Trilogy pericardial valve: hemodynamic performance and calcification in adolescent sheep
    Willem Flameng
    Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Ann Thorac Surg 85:587-92. 2008
    ..We compared this new valve with the Perimount valve (Edwards Lifesciences, Irvine, CA) in a randomized prospective study in adolescent sheep...
  57. ncbi The anti-calcification potential of a silsesquioxane nanocomposite polymer under in vitro conditions: potential material for synthetic leaflet heart valve
    Hossein Ghanbari
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Sciences, University College London, London, UK
    Acta Biomater 6:4249-60. 2010
    ..0001). These results indicate that the use of this nanocomposite in synthetic leaflets heart valves may lead to potential advantages in terms of long-term performances and durability...
  58. ncbi Geometry and degree of apposition of the CoreValve ReValving system with multislice computed tomography after implantation in patients with aortic stenosis
    Carl J Schultz
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 54:911-8. 2009
    ..Using multislice computed tomography (MSCT), we sought to evaluate the geometry and apposition of the CoreValve ReValving System (CRS, Medtronic, Luxembourgh, Luxembourgh) in patients with aortic stenosis...
  59. ncbi Aortic valve replacement with the Sorin Pericarbon Freedom stentless prosthesis: 7 years' experience in 130 patients
    Augusto D'Onofrio
    Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy
    J Thorac Cardiovasc Surg 134:491-5. 2007
    ..The aim of this single-center retrospective study was to assess midterm clinical and hemodynamic results of aortic valve replacement with the Sorin Pericarbon Freedom stentless bioprosthesis...
  60. ncbi Risk factors for pacemaker implantation following aortic valve replacement: a single centre experience
    G Limongelli
    Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy
    Heart 89:901-4. 2003
    ..To identify perioperative clinical predictors of permanent pacemaker implantation following aortic valve replacement...
  61. ncbi New percutaneous treatments for valve disease
    Louise Coats
    Great Ormond Street Hospital for Children, Great Ormond Street, London, UK
    Heart 93:639-44. 2007
  62. ncbi A new method for evaluation of cavitation near mechanical heart valves
    Peter Johansen
    Bioengineering Department, Penn State University, University Park, PA 16802, USA
    J Biomech Eng 125:663-70. 2003
    ..8806-0.9887). The new method showed that the cavitation signal could be extracted without a priori knowledge needed for setting the high-pass filter cut off frequency, nor did it introduce bandwidth limitation of the cavitation signal...
  63. ncbi New anatomically oriented transapical aortic valve implantation
    Volkmar Falk
    Klinik fur Herzchirurgie, Universitat Leipzig, Herzzentrum, Leipzig, Germany
    Ann Thorac Surg 87:925-6. 2009
    ..Here we report implantation of this new valve in a patient. The valve demonstrated excellent function with a low transvalvular gradient...
  64. ncbi Delayed dislocation of a transapically implanted aortic bioprosthesis
    Luis C Maroto
    Department of Cardiac Surgery, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Cardiothorac Surg 36:935-7. 2009
    ..We report the case of a delayed upward displacement of a prosthesis after this procedure. It is hypothesised that the asymmetric calcification of the native valve and the presence of a mitral prosthesis caused the dislocation...
  65. ncbi Normal values for Doppler echocardiographic assessment of heart valve prostheses
    Raphael Rosenhek
    Department of Cardiology, Vienna General Hospital, University of Vienna, Austria
    J Am Soc Echocardiogr 16:1116-27. 2003
    ..This study provides an updated overview on the available data of normal values to facilitate adequate interpretation of Doppler data...
  66. ncbi Electrocardiographic changes and clinical outcomes after transapical aortic valve implantation
    Marcos Gutierrez
    Quebec Heart and Lung Institute, Quebec, Quebec G1V 4G5, Canada
    Am Heart J 158:302-8. 2009
    ..The objective of our study was to determine the incidence, type, and timing of ECG changes associated with TAVI...
  67. ncbi [Selection of prosthetic heart valves for adult patients by age]
    Kazuhiro Hashimoto
    Department of Cardiovascular Surgery, Jikei University School of Medicine, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 108:69-72. 2007
    ....
  68. ncbi The year in valvular heart disease
    Shahbudin H Rahimtoola
    Griffith Center, Division of Cardiovascular Medicine, Department of Medicine, LAC+USC Medical Center, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    J Am Coll Cardiol 51:760-70. 2008
  69. ncbi An expanded polytetrafluoroethylene-autologous aortic hybrid valve for right ventricular outflow tract reconstruction in the Ross procedure
    Takako Miyazaki
    Department of Pediatric Cardiovascular Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi, Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Interact Cardiovasc Thorac Surg 6:163-6. 2007
    ..Given its theoretical growth potential, we speculate that this valve could be a good choice for RVOT reconstruction in the Ross procedure, especially for young children...
  70. ncbi Fate of the autograft and homograft following Ross aortic valve replacement: reoperative frequency, outcome, and management
    John W Brown
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, Indiana 46202 5123, USA
    J Heart Valve Dis 15:253-9; discusson 259-60. 2006
    ..The authors' institutional mid-term experience was reviewed to assess autograft and homograft hemodynamics, growth profile of the autograft, and reoperative frequency following Ross AVR...
  71. ncbi Mid-term results after Epic xenograft implantation for aortic, mitral, and double valve replacement
    Sven Lehmann
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    J Heart Valve Dis 16:641-8; discussion 648. 2007
    ..The study aim was to evaluate the mid-term results after implantation of the stented porcine xenograft (Epic valve with Linx anticalcification treatment) in elderly patients...
  72. ncbi Left ventricular outflow tract reconstruction for annular erosion using a polyester graft
    Paolo Masetti
    Division of Cardiovascular and Thoracic Surgery, Missouri Baptist Medical Center, St Louis, Missouri 63131, USA
    Ann Thorac Surg 85:345-6. 2008
    ..The graft is then everted and sutured to a composite graft. Interposition polyester grafts from the coronary arteries are attached to the composite graft above the valve...
  73. ncbi Twenty-year results of the Hancock II bioprosthesis
    Michael A Borger
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Heart Valve Dis 15:49-55; discussion 55-6. 2006
    ..The Hancock II bioprosthesis (HII) has several design features designed to increase its durability. The study aim was to determine very long-term outcomes for the HII valve in a large patient population...
  74. ncbi Stentless valves treated by the L-hydro process in the aortic position in sheep
    Paulo C Santos
    Department of Cardiovascular Surgery, Escola Paulista de Medicina UNIFESP, Sao Paulo, Brazil
    Asian Cardiovasc Thorac Ann 15:413-7. 2007
    ..A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model...
  75. ncbi The stentless freestyle bioprosthesis: impact of age over 80 years on quality of life, perioperative, and mid-term outcome
    Jürgen Ennker
    Heart Institute Lahr Baden, Lahr, Germany
    J Card Surg 21:379-85. 2006
    ..The steadily increasing life expectancy of the population in the Western World, together with the progress in noninvasive diagnostic methods and operating techniques lead to an increase in aortic valve surgery in elderly people...
  76. ncbi Influence of socioeconomic status on survival after primary aortic or mitral valve replacement
    J P Bagger
    United Kingdom Heart Valve Registry, Cardiothoracic Directorate, Hammersmith Hospital, London, UK
    Heart 94:182-5. 2008
    ..We sought to evaluate whether socioeconomic status influences outcome after first-time single aortic or mitral valve replacement...
  77. ncbi [Haemorrhagic and thrombo-embolic complications in patients with prosthetic valves--the under-appreciated problem with no safe solutions]
    Przemysław Trzeciak
    III Katedra i Oddział Kliniczny Kardiologii SAM, slaskie Centrum Chorob Serca, ul Szpitalna 2, 41 800 Zabrze
    Kardiol Pol 64:1038-42. 2006
  78. ncbi One year hemodynamic performance of the Perimount Magna pericardial xenograft and the Medtronic Mosaic bioprosthesis in the aortic position: a prospective randomized study
    María José Dalmau
    Department of Cardiac Surgery, Salamanca University Hospital, Paseo de San Vicente 58 182, 37007 Salamanca, Spain
    Interact Cardiovasc Thorac Surg 6:345-9. 2007
    ..8% (MM) vs. 6.9% (EPM) of the patients (P=0.01). When the same AAD is taken as a reference, the EPM-valve was hemodynamically superior to the MM-bioprosthesis. The EPM-prosthesis significantly reduced the incidence of PPM...
  79. ncbi Influence of orientation of bi-leaflet valve prostheses on coronary perfusion pressure in humans
    Marcel van't Veer
    Department of Biomedical Engineering, Cardiovascular Biomechanics, University of Technology Eindhoven, Michelangelolaan 2, P O Box 1350, 5602 ZA Eindhoven, The Netherlands
    Interact Cardiovasc Thorac Surg 6:588-92. 2007
    ..Only small non-significant differences in myocardial perfusion pressure were found between different orientations of a bi-leaflet prosthesis or between bi-leaflet prostheses and bio-prostheses in P(ao)-P(root) and P(root)-P(cor)...
  80. ncbi Traumatic dehiscence of Medtronic Freestyle stentless bioprosthesis
    Turki Albacker
    Division of Cardiac Surgery, McGill University, Montreal, Canada
    Ann Thorac Surg 86:643-5. 2008
    ..At reoperation, the patient underwent reconstruction of the aortic root and Bentall procedure with a size 23 mechanical aortic valved conduit...
  81. ncbi Effect of prior valve type on mortality in reoperative valve surgery
    Gilbert H L Tang
    Division of Cardiovascular Surgery, Toronto General Hospital, Toronto, Ontario, Canada
    Ann Thorac Surg 83:938-45. 2007
    ..The purpose of this study is to examine the effect of previously implanted valve type on hospital mortality in reoperative valve surgery...
  82. ncbi Allografts for aortic valve or root replacement: insights from an 18-year single-center prospective follow-up study
    Johanna J M Takkenberg
    Department of Cardio Thoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Cardiothorac Surg 31:851-9. 2007
    ..In this light we analyzed our ongoing prospective allograft AVR cohort and compared allograft durability with other biological aortic valve substitutes...
  83. ncbi Valve type and long-term outcomes after aortic valve replacement in older patients
    E B Schelbert
    Division of Cardiovascular Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Heart 94:1181-8. 2008
    ....
  84. ncbi Predicted patient outcome after aortic valve replacement with Medtronic Stentless Freestyle bioprostheses
    A Pieter Kappetein
    Department of Cardio Thoracic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Heart Valve Dis 16:423-8; discussion 429. 2007
    ....
  85. ncbi Long-term results of aortic valve replacement with a small St. Jude medical valve in Japanese patients
    Kazuhiro Yoshikawa
    Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Ann Thorac Surg 85:1303-8. 2008
    ..This study evaluated the long-term results after aortic valve replacement with a small valve from St. Jude Medical (St. Paul, MN)...
  86. ncbi Evaluation of biological aortic valve prostheses by dual source computer tomography and anatomic measurements for potential transapical valve-in-valve procedure
    Jurg Grunenfelder
    Clinic for Cardiovascular Surgery, University Hospital Zurich, Ramistr 100, 8091 Zurich, Switzerland
    Interact Cardiovasc Thorac Surg 7:195-9; discussion 199-200. 2008
    ..These measurements represent a prerequisite for preoperative planning and increase the awareness to detect potential procedural problems of the valve-in-valve concept...
  87. ncbi Mechanical versus bioprosthetic valve replacement in middle-aged patients
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont. K1Y 4W7, Canada
    Eur J Cardiothorac Surg 30:485-91. 2006
    ..At present, these data do not support lowering the usual cutoff for implantation of a tissue valve below the age of 65...
  88. ncbi An audit of anticoagulation practice among UK cardiothoracic consultant surgeons following valve replacement/repair
    Paul Vaughan
    Department of Thoracic Surgery, Glenfield Hospital, Leicester, UK
    J Heart Valve Dis 14:576-82. 2005
    ..The American College of Chest Physicians made similar recommendations in 2001. The present survey was conducted to review anticoagulation practice among UK consultant cardiac surgeons, and to assess compliance with these guidelines...
  89. ncbi Hemodynamic performance and clinical consequences of aortic valve replacement with 21-mm sized pericardial bioprostheses
    U Boeken
    Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-University Hospital, , Germany
    Thorac Cardiovasc Surg 53:281-4. 2005
    ..As the outcome of patients with a 21 mm pericardial valve was no worse than that in patients with bigger valves, enlarging procedures for the aortic root are not necessary in the majority of these patients...
  90. ncbi Durability of pericardial versus porcine aortic valves
    Guangqiang Gao
    Providence Health System, Portland, Oregon, USA
    J Am Coll Cardiol 44:384-8. 2004
    ..Its freedom from SVD and reoperation makes it our current bioprosthesis of choice for AVR in appropriately selected patients...
  91. ncbi The experience with porcine bioprostheses at Padua University
    Gino Gerosa
    Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy
    J Heart Valve Dis 13:S44-8. 2004
  92. ncbi The effective orifice area/patient aortic annulus area ratio: a better way to compare different bioprostheses? A prospective randomized comparison of the Mosaic and Perimount bioprostheses in the aortic position
    Walter B Eichinger
    Department of Cardiovascular Surgery, German Heart Centre Munich, Lazarettstr 36, 80636 Munich, Germany
    J Heart Valve Dis 13:382-8; discussion 388-9. 2004
    ....
  93. ncbi The aortic Elan stentless aortic valve: excellent hemodynamics and ease of implantation
    M Flynn
    Department of Cardiothoracic Surgery and Clinical Research Initiative in Heart Failure, Western Infirmary, Glasgow, UK
    Semin Thorac Cardiovasc Surg 13:48-54. 2001
    ..Ease of implantation is evidenced by favorable ischemic times. This valve may offer an option to homograft in acute aortic endocarditis. Long-term results are awaited...
  94. ncbi Is patient outcome adversely affected by early versus late prosthesis-patient mismatch?
    Gideon Cohen
    Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    J Card Surg 19:98. 2004
  95. ncbi Patient-prosthesis mismatch after small-size stentless aortic valve replacement
    Sandro Gelsomino
    Department of Cardiovascular Sciences, General Hospital S Maria della Misericordia, Udine, Italy
    J Card Surg 19:91-7. 2004
    ..Based on previous observations a mismatch was defined as EOAI <or= 0.85 cm2/m2...
  96. ncbi Value of intraoperative transesophageal echocardiography in preventing serious complications during valvular surgery. A report of four cases
    Hiromichi Fujii
    Second Department of Surgery, Osaka City University Medical School, Osaka, Japan
    J Heart Valve Dis 11:135-8. 2002
    ..Routine intraoperative TEE in valve surgery permits the identification and management of potentially serious complications before discontinuing cardiopulmonary bypass...
  97. ncbi Mid-term follow-up in patients with Biocor porcine bioprostheses
    Tomaso Bottio
    Department of Cardiovascular Surgery, University of Padua Medical School, Padua, Italy
    Cardiovasc Surg 10:238-44. 2002
    ..We reviewed survival and prosthetic complications of Biocor porcine bioprostheses implanted in mitral, aortic and mitro-aortic position...
  98. ncbi Bivalvular mechanical mitral-aortic valve replacement in 254 patients: long-term results--a 22-year follow-up
    Jean Paul Remadi
    Cardiovascular Surgery Unit, G and R Läennec University Hospital, Nantes, France
    Ann Thorac Surg 76:487-92. 2003
    ..The follow-up was 22 years (1979 to 2001). The last patient was operated on 12 years before the end of the follow-up...
  99. ncbi Reduction of mechanical heart valve thrombosis through a clinical audit
    V Bharat
    Department of Cardiology, Tata Main Hospital, Jamshedpur, India
    J Heart Valve Dis 12:362-9. 2003
    ..Despite successful surgery and regular hospital visits, long-term survival was compromised by anticoagulation-related complications...
  100. ncbi Unexpected durability of Smeloff-Cutter aortic ball valve prosthesis
    Yuji Naito
    Department of Cardiovascular Surgery, Yamanashi Central Hospital, Yamanashi, Japan
    Ann Thorac Surg 75:1633-5. 2003
    ..The patient's aortic ball valve was nearly intact with perivalvular leakage probably causing the aortic regurgitation. Our experience documents longer durability for the Smeloff-Cutter prosthesis than has been reported to date...
  101. ncbi Facilitated insertion of the Hancock II bioprosthesis
    Vivek Rao
    Department of Cardiothoracic Surgery, New York Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Card Surg 17:232-4. 2002

Research Grants76

  1. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2003
    ..To achieve these aims, it is proposed to use the most current techniques for measurement of tissue mechanical properties. ..
  2. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2007
    The goal of this proposal is to produce a fully characterized polyurethane heart valve prosthesis that will be ready for clinical evaluation. Existing replacement valves suffer from several shortcomings...
  3. DENTIN BIOMINERALIZATION
    Charles Sfeir; Fiscal Year: 2007
    ..This data will also provide basic knowledge for designing treatment of ectopic mineralization specifically in diseases as such kidney stones or failing heart valve prosthesis.
  4. Training in Biomechanics in Regenerative Medicine
    Michael Sacks; Fiscal Year: 2007
    ..Coursework includes intensive life science, and biomechanics is utilized to provide the students with a thorough grounding in both areas. Skills acquired in these courses are combined in later courses and the trainees' research. ..
  5. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2009
    ..It is envisioned that it will also facilitate the use of these devices for long term therapy by reducing the need for difficult pharmacological management with anticoagulants, which is mandated for most existing devices. ..
  6. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael Sacks; Fiscal Year: 2007
    ..Relevance to public health includes the develop of valved pulmonary conduits for the pediatric population that can grow with the patient, minimizing the need for continued re-operations to bring the patient to adulthood. ..
  7. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2007
    ..It is envisioned that it will also facilitate the use of these devices for long term therapy by reducing the need for difficult pharmacological management with anticoagulants, which is mandated for most existing devices. ..
  8. Biomechanical optimization of TE heart valves
    Michael S Sacks; Fiscal Year: 2010
    ..Specific Aim 3 - Evaluate the EPC-seeded ES-PEUU scaffold's ability to perform in-vivo using a single leaflet model. ..
  9. Biomechanical optimization of TE heart valves
    Michael Sacks; Fiscal Year: 2007
    ..Specific Aim 3 - Evaluate the EPC-seeded ES-PEUU scaffold's ability to perform in-vivo using a single leaflet model. ..
  10. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael S Sacks; Fiscal Year: 2010
    ..Relevance to public health includes the develop of valved pulmonary conduits for the pediatric population that can grow with the patient, minimizing the need for continued re-operations to bring the patient to adulthood. ..
  11. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  12. Biomechanical optimization of TE heart valves
    Michael Sacks; Fiscal Year: 2004
    ..3) Perform in-vitro evaluation of TEHV fabricated using optimal scaffold designs and 3D guided RV outflow track geometry using novel bioreactor loop imaging system. ..
  13. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  14. Translational studies in Heart Failure Gene Therapy
    Charles R Bridges; Fiscal Year: 2010
    ..Successful completion of this study may lead to alternatives to heart transplantation and permanent mechanical assist devices in the treatment of end stage heart failure. ..
  15. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2007
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  16. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2010
    ....
  17. Translational studies in Heart Failure Gene Therapy
    Charles Bridges; Fiscal Year: 2009
    ..Successful completion of this study may lead to alternatives to heart transplantation and permanent mechanical assist devices in the treatment of end stage heart failure. ..
  18. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2007
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  19. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  20. Pathophysiology/Clinical Outcomes/Patients/Endocarditis
    Christopher Cabell; Fiscal Year: 2005
    ..The findings of this study have implications not only for clinical care but will also provide a foundation of knowledge and network of investigators from which subsequent randomized trials can be conducted. ..
  21. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  22. BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
    Gerard Ateshian; Fiscal Year: 2007
    ..abstract_text> ..
  23. Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
    Clark T Hung; Fiscal Year: 2010
    ..The technology proposed in this application will facilitate engineering of large cartilage tissue constructs needed to resurface defects in OA joints. ..
  24. GENETICS AND GENOMICS OF HUMAN DISEASE
    Richard Lifton; Fiscal Year: 2007
    ..Support is requested for 10 graduate students per year for a five-year period. ..
  25. Studies in pig-to-primate cardiac xenotransplantation
    CHRISTOPHER MC GREGOR; Fiscal Year: 2007
    ..In addition, by attempting to reverse rejection episodes with plasmapheresis we will identify the initiating mechanism of graft rejection. This proposal, if successful, lays the groundwork for the clinical application of cardiac XTx. ..
  26. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  27. BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
    Gerard Ateshian; Fiscal Year: 2003
    ..05Mpa-5 Mpa, frequencies of 0.0005Hz - 0.5 Hz and up to 10 percent compressive strains, with and without enzymatic (collagenase, chondroitinase ABC and hyaluronidase) treatments. ..
  28. Anisotropy and Nonlinearity of Cartilage Mechanics
    Gerard Ateshian; Fiscal Year: 2007
    ..abstract_text> ..