heart valve prosthesis

Summary

Summary: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.

Top Publications

  1. ncbi Evidence of mitigated calcification of the Mosaic versus Hancock Standard valve xenograft in the mitral position of young sheep
    Patricia A Weber
    International Heart Institute of Montana Foundation at Saint Patrick Hospital and Health Sciences Center and The University of Montana, Missoula, Mont, USA
    J Thorac Cardiovasc Surg 132:1137-43. 2006
  2. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  3. doi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
  4. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
  5. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
  6. doi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
  7. doi Diagnostic evaluation of left-sided prosthetic heart valve dysfunction
    Jesse Habets
    Department of Radiology, University Medical Center, Utrecht, P O Box 85500, 3508 GA, The Netherlands j habets umcutrecht nl
    Nat Rev Cardiol 8:466-78. 2011
  8. pmc Prosthetic heart valve assessment with multidetector-row CT: imaging characteristics of 91 valves in 83 patients
    Jesse Habets
    Department of Radiology, UMC Utrecht, P O Box 85500, E01 132, 3508, GA, Utrecht, The Netherlands
    Eur Radiol 21:1390-6. 2011
  9. doi Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard
    I Chen Tsai
    Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Eur Radiol 19:857-67. 2009
  10. doi Prosthesis-patient mismatch: an update
    Jean G Dumesnil
    Quebec Heart and Lung Institute, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada G1V 4G5
    Curr Cardiol Rep 13:250-7. 2011

Detail Information

Publications239 found, 100 shown here

  1. ncbi Evidence of mitigated calcification of the Mosaic versus Hancock Standard valve xenograft in the mitral position of young sheep
    Patricia A Weber
    International Heart Institute of Montana Foundation at Saint Patrick Hospital and Health Sciences Center and The University of Montana, Missoula, Mont, USA
    J Thorac Cardiovasc Surg 132:1137-43. 2006
    ..The primary goal was to evaluate the efficacy of alpha-amino-oleic acid as an anticalcification treatment...
  2. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  3. doi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
    ..The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008...
  4. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported...
  5. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    ....
  6. doi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
    ..Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known...
  7. doi Diagnostic evaluation of left-sided prosthetic heart valve dysfunction
    Jesse Habets
    Department of Radiology, University Medical Center, Utrecht, P O Box 85500, 3508 GA, The Netherlands j habets umcutrecht nl
    Nat Rev Cardiol 8:466-78. 2011
    ..In this Review, we discuss the use of established imaging modalities for the detection of left-sided mechanical and biological PHV dysfunction and discuss the complementary role of MDCT in this context...
  8. pmc Prosthetic heart valve assessment with multidetector-row CT: imaging characteristics of 91 valves in 83 patients
    Jesse Habets
    Department of Radiology, UMC Utrecht, P O Box 85500, E01 132, 3508, GA, Utrecht, The Netherlands
    Eur Radiol 21:1390-6. 2011
    ..Multidetector CT (MDCT) has shown potential for prosthetic heart valve (PHV) assessment. We assessed the image quality of different PHV types to determine which valves are suitable for MDCT evaluation...
  9. doi Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard
    I Chen Tsai
    Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Eur Radiol 19:857-67. 2009
    ..Except for images impaired by severe beam-hardening artifacts, MDCT provides excellent delineation of prosthetic valve disorders...
  10. doi Prosthesis-patient mismatch: an update
    Jean G Dumesnil
    Quebec Heart and Lung Institute, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada G1V 4G5
    Curr Cardiol Rep 13:250-7. 2011
    ..Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation...
  11. pmc Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement
    Rodrigo Bagur
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada G1V 4G5
    Eur Heart J 31:865-74. 2010
    ..surgical aortic valve replacement (SAVR) in patients with pre-procedural chronic kidney disease (CKD)...
  12. doi Registry of transcatheter aortic-valve implantation in high-risk patients
    Martine Gilard
    Centre Hospitalier Universitaire CHU Brest, Brest, France
    N Engl J Med 366:1705-15. 2012
    ..We report the results of a prospective multicenter study of the French national transcatheter aortic-valve implantation registry, FRANCE 2...
  13. doi Aortic annulus evaluation in transcatheter aortic valve implantation
    Andrea Hutter
    Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
    Catheter Cardiovasc Interv 76:1009-19. 2010
    ..We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI)...
  14. pmc The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells
    Sharan Ramaswamy
    Cardiovascular Biomechanics Laboratory, Department of Bioengineering, Swanson School of Engineering, The McGowan Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 31:1114-25. 2010
    ....
  15. doi Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) High Risk Study
    Patrick L Whitlow
    Cleveland Clinic, Ohio 44195, USA
    J Am Coll Cardiol 59:130-9. 2012
    ....
  16. doi Percutaneous transarterial aortic valve implantation: what do we know?
    John Webb
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Heart J 32:140-7. 2011
    ..Nevertheless considerable work needs to be done before the indications for TAVI are expanded into lower risk groups. We review what is currently known about percutaneous transarterial implantation of the aortic valve...
  17. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  18. doi Aortic stenosis
    Blase A Carabello
    Baylor College of Medicine, Department of Medicine and Veterans Affairs Medical Center, Houston, TX, USA
    Lancet 373:956-66. 2009
    ..We discuss these issues in this Review...
  19. doi Comparison of multidetector-row computed tomography to echocardiography and fluoroscopy for evaluation of patients with mechanical prosthetic valve obstruction
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken, Zwolle, The Netherlands
    Am J Cardiol 104:1128-34. 2009
    ..In conclusion, this initial experience demonstrates that multidetector-row computed tomography can identify causes of prosthetic valve obstruction that constitute indications for surgery but are missed at echocardiography or fluoroscopy...
  20. doi The role of ECG-gated MDCT in the evaluation of aortic and mitral mechanical valves: initial experience
    Eli Konen
    Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
    AJR Am J Roentgenol 191:26-31. 2008
    ..The objective of our study was to evaluate the role of ECG-gated MDCT in the functional evaluation of mechanical prosthetic aortic and mitral valves...
  21. doi Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography
    Arnold C T Ng
    Department of Cardiology, The Department of Cardiothoracic Surgery, and the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Circ Cardiovasc Imaging 3:94-102. 2010
    ..We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI)...
  22. ncbi Multidetector-row computed tomography imaging characteristics of mechanical prosthetic valves
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken Zwolle, The Netherlands
    J Heart Valve Dis 20:216-22. 2011
    ..A pulsatile in vitro model was developed to study the MDCT imaging characteristics of mechanical heart valves (MHVs)...
  23. ncbi Ross operation with a tissue-engineered heart valve
    Pascal M Dohmen
    Department of Cardiovascular Surgery, Charite, Humboldt University Berlin, Germany
    Ann Thorac Surg 74:1438-42. 2002
    ..In this report a viable heart valve was created from decellularized cryopreserved pulmonary allograft that was seeded with viable autologous vascular endothelial cells (AVEC)...
  24. doi Role of echocardiography in percutaneous aortic valve implantation
    Robert R Moss
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    JACC Cardiovasc Imaging 1:15-24. 2008
    ..This study was designed to investigate the usefulness and limitations of echocardiography in optimizing the outcome of percutaneous aortic valve implantation...
  25. doi 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to
    Robert O Bonow
    J Am Coll Cardiol 52:e1-142. 2008
  26. ncbi Prognostic significance of newly acquired bundle branch block after aortic valve replacement
    Ziad El-Khally
    Department of Cardiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Am J Cardiol 94:1008-11. 2004
    ..A new and persistent BBB acquired after AVR is associated with an increased adverse event rate. This finding suggests that early prophylactic pacemaker implantation should be considered in these patients...
  27. ncbi Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitation
    Philip S Mullenix
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Valve Dis 17:666-9. 2008
    ..A bioprosthetic valve was installed and the patient recovered uneventfully. The diagnosis and surgical management of this problem are discussed...
  28. pmc Multidetector CT imaging of mechanical prosthetic heart valves: quantification of artifacts with a pulsatile in-vitro model
    Petr Symersky
    Department of Cardiothoracic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Eur Radiol 21:2103-10. 2011
    ..We quantified artifacts of four PHV using a pulsatile in-vitro model and assessed the relation to leaflet motion and valve design...
  29. ncbi Patient-prosthesis mismatch does not affect survival following aortic valve replacement
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Cardiothorac Surg 30:10-4. 2006
    ..We analysed the effect of PPM at values predicting severe mismatch on survival following AVR in our unit...
  30. ncbi Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 30:15-9. 2006
    ..The aim of this study was to evaluate the impact of patient prosthesis mismatch (PPM) and additional risk factors on outcome after aortic valve replacement (AVR)...
  31. pmc A novel iterative reconstruction algorithm allows reduced dose multidetector-row CT imaging of mechanical prosthetic heart valves
    Jesse Habets
    Department of Radiology, University Medical Center Utrecht, PO Box 85500, E01 132, 3508 GA Utrecht, The Netherlands
    Int J Cardiovasc Imaging 28:1567-75. 2012
    ..5 ± 1.7 vs. 16.3 ± 1.6, mean ± SD, respectively, P = 1.0). IR allows ECG-gated PHV imaging with similar image noise and PHV artifacts at 50% less dose compared to conventional FBP in an pulsatile in vitro model...
  32. ncbi The impact of patient-prosthesis mismatch on late outcomes after mitral valve replacement
    Buu Khanh Lam
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 133:1464-73. 2007
    ..This study was conducted to determine the impact of patient-prosthesis mismatch on recurrent congestive heart failure, postoperative pulmonary hypertension, and late survival after mitral valve replacement...
  33. ncbi Calcification of tissue heart valve substitutes: progress toward understanding and prevention
    Frederick J Schoen
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, The Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 79:1072-80. 2005
    ....
  34. ncbi Anticoagulation in patients with mechanical valves during pregnancy
    Muhammad A Geelani
    Department of Cardiothoracic and Vascular Surgery, GB Pant Hospital, New Delhi 110002, India
    Asian Cardiovasc Thorac Ann 13:30-3. 2005
    ..We conclude that warfarin is safe and convenient to use during pregnancy. The teratogenic effects of warfarin during the 1(st) trimester are overstated, and switching to heparin is not mandatory...
  35. doi Frequency of conduction abnormalities after transcatheter aortic valve implantation with the Medtronic-CoreValve and the effect on left ventricular ejection fraction
    Apostolos Tzikas
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 107:285-9. 2011
    ..In conclusion, the induction of new conduction abnormalities after TAVI with the Medtronic-CoreValve was associated with a lack of improvement in LV systolic function...
  36. ncbi Valvular heart disease and pregnancy: part II: prosthetic valves
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Am Coll Cardiol 46:403-10. 2005
    ....
  37. ncbi Prosthesis-patient mismatch after aortic valve replacement: impact of age and body size on late survival
    Marc R Moon
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Thorac Surg 81:481-8; discussion 489. 2006
    ..The purpose of this study was to identify patient subgroups in which prosthesis-patient mismatch most influenced late survival...
  38. doi The anti-calcification potential of a silsesquioxane nanocomposite polymer under in vitro conditions: potential material for synthetic leaflet heart valve
    Hossein Ghanbari
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Sciences, University College London, London, UK
    Acta Biomater 6:4249-60. 2010
    ..0001). These results indicate that the use of this nanocomposite in synthetic leaflets heart valves may lead to potential advantages in terms of long-term performances and durability...
  39. doi Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve
    Nicolo Piazza
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    JACC Cardiovasc Interv 1:310-6. 2008
    ..In this retrospective study, we examined the incidence of post-procedural conduction abnormalities and the need for pacing in patients undergoing percutaneous implantation of the aortic valve...
  40. doi Early conduction disorders following percutaneous aortic valve replacement
    Valeria Calvi
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Pacing Clin Electrophysiol 32:S126-30. 2009
    ..We examined the incidence and characteristics of CD in the immediate postoperative period after PAVR, and the need for permanent pacemaker (PPM) implantation...
  41. doi Long-term outcomes after isolated aortic valve replacement in octogenarians: a modern perspective
    Vinod H Thourani
    Clinical Research Unit, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 86:1458-64; discussion 1464-5. 2008
    ..This study compares the short- and long-term survival outcomes of octogenarians after AVR with younger age groups in the modern surgical era...
  42. ncbi Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec, Canada
    J Thorac Cardiovasc Surg 132:401-6. 2006
    ..This study evaluates the mechanisms and clinical presentation of structural valve deterioration in the Freestyle stentless bioprosthesis...
  43. doi Unexpected complications of transapical aortic valve implantation
    Nawwar Al-Attar
    Department of Cardiovascular Surgery, Bichat Claude Bernard Hospital, Paris, France
    Ann Thorac Surg 88:90-4. 2009
    ..However, specific problems of this new procedure are not well-described. Unexpected complications due to the procedure and their management are reported...
  44. doi Deleterious outcome of No-React-treated stentless valved conduits after aortic root replacement: why were warnings ignored?
    Thierry P Carrel
    Department of Cardiovascular Surgery, University Hospital, Berne, Switzerland
    J Thorac Cardiovasc Surg 136:52-7. 2008
    ....
  45. doi Progress and current status of percutaneous aortic valve replacement: results of three device generations of the CoreValve Revalving system
    Eberhard Grube
    Departments of Cardiology, Cardiac Surgery, and Anaesthesiology, HELIOS Heart Center Siegburg, Ringstrasse 49, Siegburg, Germany
    Circ Cardiovasc Interv 1:167-75. 2008
    ..This study was intended to provide a summary of the development and current safety and efficacy status of the self-expanding CoreValve Revalving prosthesis...
  46. ncbi Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Res 108:3-13. 2002
    ..The objectives of this review are to focus on practical issues relating to perioperative anticoagulation and the implementation of a perioperative anticoagulation management approach that can be used in everyday clinical practice...
  47. ncbi Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN prosthesis: incidence and impact on outcome
    Gregory Ducrocq
    Department of Cardiology, Bichat Claude Bernard Hospital, Paris, France
    EuroIntervention 5:666-72. 2010
    ..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...
  48. doi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry...
  49. doi Guidelines for reporting mortality and morbidity after cardiac valve interventions
    Cary W Akins
    The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 85:1490-5. 2008
  50. ncbi Choice of prosthetic heart valve for adult patients
    Shahbudin H Rahimtoola
    Griffith Center, Division of Cardiovascular Medicine, Department of Medicine, LAC USC Medical Center, Keck School of Medicine at the University of Southern California, 2025 Zonal Avenue, Los Angeles, CA 90033, USA
    J Am Coll Cardiol 41:893-904. 2003
    ..In individual patients there may be exceptions to these general rules...
  51. ncbi Treatment of destructive aortic valve endocarditis with the Freestyle Aortic Root Bioprosthesis
    Ludwig C Müller
    Department of Cardiac Surgery, University of Innsbruck, Innsbruck, Austria
    Ann Thorac Surg 75:453-6. 2003
    ..Homograft aortic roots are the conduits of choice, but because they are not available in all cases, alternative conduits are needed...
  52. ncbi Routine enlargement of the small aortic root: a preventive strategy to minimize mismatch
    Luis J Castro
    Department of Cardiovascular Surgery, Sequoia Hospital, Redwood City, California, USA
    Ann Thorac Surg 74:31-6; discussion 36. 2002
    ..We routinely use aortic root enlargement (ARE) as part of one strategy to avoid prosthesis-patient mismatch in patients with relatively small aortic roots who are undergoing aortic valve replacement (AVR)...
  53. ncbi Does glutaraldehyde induce calcification of bioprosthetic tissues?
    A Vincentelli
    Department of Cardiovascular Surgery, Cardiologic Hospital, Lille, France
    Ann Thorac Surg 66:S255-8. 1998
    ..We investigated whether the origin of the tissue, autologous or heterologous, could have a more prominent role in the process of calcification...
  54. ncbi First report on a human percutaneous transluminal implantation of a self-expanding valve prosthesis for interventional treatment of aortic valve stenosis
    Eberhard Grube
    Department of Cardiology, Heart Center Siegburg, Siegburg, Germany
    Catheter Cardiovasc Interv 66:465-9. 2005
    ..7 cm2). Surgical valve replacement had been declined for the patient because of comorbidities, including previous bypass surgery...
  55. ncbi Anticoagulation in pregnant women with prosthetic heart valves
    Stephan Danik
    Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 71:322-9. 2004
    ..A discussion of the available data on anticoagulation in pregnant women with prosthetic heart valves is presented here, to inform the clinician and the patient of the risks and benefits of the options presently available...
  56. pmc PCR detection of bacteria on cardiac valves of patients with treated bacterial endocarditis
    Clarisse Rovery
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Hôpital dde la Timone, Marseille, France
    J Clin Microbiol 43:163-7. 2005
    ....
  57. ncbi Pregnancy outcome in women with prosthetic heart valves
    Anwar H Nassar
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon
    Am J Obstet Gynecol 191:1009-13. 2004
    ..This study was undertaken to evaluate the risks and pregnancy outcome in women with prosthetic heart valves on different anticoagulent regimens...
  58. ncbi Characterization of the immune response to valve bioprostheses and its role in primary tissue failure
    P Human
    Department of Cardiothoracic Surgery, Cape Heart Center, University of Cape Town Medical School, South Africa
    Ann Thorac Surg 71:S385-8. 2001
    ....
  59. ncbi Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II6-10. 1999
    ..The aim of this prospectively randomized study was to evaluate left ventricular hypertrophy and its regression after stentless versus conventional biological aortic valve replacement...
  60. doi Survival after transapical and transfemoral aortic valve implantation: talking about two different patient populations
    Sabine Bleiziffer
    Clinic for Cardiovascular Surgery, German Heart Center Munich, Lazarettstrasse 36, Munich, Germany
    J Thorac Cardiovasc Surg 138:1073-80. 2009
    ..We analyzed survival in patients undergoing transcatheter aortic valve implantation with special emphasis on the access site for implantation...
  61. ncbi Fibrin gel -- advantages of a new scaffold in cardiovascular tissue engineering
    S Jockenhoevel
    Clinic for Thoracic and Cardiovascular Surgery, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Eur J Cardiothorac Surg 19:424-30. 2001
    ..central role in the creation of 3-D structures in cardiovascular tissue engineering like small vessels or heart valve prosthesis. An ideal scaffold should have tissue-like mechanical properties and a complete immunologic integrity...
  62. ncbi Vascular complications with transcatheter aortic valve implantation using the 18 Fr Medtronic CoreValve System: the Rotterdam experience
    Nicolas M Van Mieghem
    Department of Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, The Netherlands
    EuroIntervention 5:673-9. 2010
    ..Access site complications, therefore, can be a concern. The aim of this study is to present the 30-day incidence of major and minor vascular complications in patients treated with the third generation 18 Fr Medtronic CoreValve System...
  63. ncbi Percutaneous transarterial aortic valve replacement in selected high-risk patients with aortic stenosis
    John G Webb
    Division of Cardiology, St Paul s Hospital and the Centre for Health Evaluation and Outcome Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Circulation 116:755-63. 2007
    ..Percutaneous aortic valve replacement represents an endovascular alternative to conventional open heart surgery without the need for sternotomy, aortotomy, or cardiopulmonary bypass...
  64. doi A novel nanocomposite polymer for development of synthetic heart valve leaflets
    Asmeret G Kidane
    Centre for Nanotechnology, Biomaterials and Tissue Engineering, UCL Division of Surgery and Interventional Science, University College London, London NW3 2PF, UK
    Acta Biomater 5:2409-17. 2009
    ..001) (at 37 degrees C) as the thickness increased from 100microm (51.0+/-3.3Nmm(-1)) to 200microm (63+/-1.5Nmm(-1)). The surface of POSS-PCU was significantly less hydrophilic than that of PCU...
  65. doi Predictors for permanent pacemaker requirement after transcatheter aortic valve implantation with the CoreValve bioprosthesis
    Hasan Jilaihawi
    Glenfield Hospital, Leicester, United Kingdom
    Am Heart J 157:860-6. 2009
    ..We hypothesized that the need for PPM after CoreValve (Corevalve Inc, Irvine, CA) can be predicted with a combination of baseline variables...
  66. doi United States feasibility study of transcatheter insertion of a stented aortic valve by the left ventricular apex
    Lars G Svensson
    Center for Aortic Surgery, Marfan Syndrome and Connective Tissue Disorders Clinic, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Thorac Surg 86:46-54; discussion 54-5. 2008
    ..We report on a Food and Drug Administration approved feasibility study of a less invasive transcatheter approach to potentially treat these high-risk patients...
  67. pmc Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography
    A Ionescu
    University of Wales College of Medicine, Cardiff, UK
    Heart 89:1316-21. 2003
    ..To assess the prevalence, mechanisms, and significance of paraprosthetic regurgitation detected incidentally by transoesophageal echocardiography (TOE) in patients after heart valve replacement...
  68. pmc Staphylococcus lugdunensis infective endocarditis: description of 10 cases and analysis of native valve, prosthetic valve, and pacemaker lead endocarditis clinical profiles
    I Anguera
    Department of Cardiology, Corporacio Parc Tauli, Hospital de Sabadell, Sabadell, Spain
    Heart 91:e10. 2005
    ..To evaluate the incidence and the clinical and echocardiographic features of infective endocarditis (IE) caused by Staphylococcus lugdunensis and to identify the prognostic factors of surgery and mortality in this disease...
  69. doi Transapical minimally invasive aortic valve implantation; the initial 50 patients
    Thomas Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Eur J Cardiothorac Surg 33:983-8. 2008
    ..To evaluate the feasibility of minimally invasive transapical beating heart aortic valve implantation (TAP-AVI) for high-risk patients with aortic stenosis...
  70. ncbi Results of isolated valve replacement in hemodialysis patients
    Wataru Kato
    Department of Cardiothoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Asian Cardiovasc Thorac Ann 15:386-91. 2007
    ..The results demonstrate an acceptable long-term outcome. A bileaflet mechanical valve managed with mild anticoagulation therapy is a reasonable strategy for hemodialysis patients...
  71. doi Sequential changes in myocardial function after valve replacement for aortic stenosis by speckle tracking echocardiography
    Christian Rost
    University of Erlangen, Erlangen, Germany
    Eur J Echocardiogr 11:584-9. 2010
    ..Speckle tracking echocardiography (STE) was applied to evaluate longitudinal, radial, and circumferential function in patients with aortic stenosis (AS) before, within 1 week, and 6 months after aortic valve replacement (AVR)...
  72. ncbi Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo
    Stanley J Stachelek
    Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 81:47-55. 2006
    ....
  73. ncbi The influence of patient-prosthesis mismatch on in-hospital complications and early mortality after aortic valve replacement
    Shahab Nozohoor
    Departments of Cardiothoracic Surgery, Lund University Hospital, Lund, Sweden
    J Heart Valve Dis 16:475-82. 2007
    ..The study aim was to analyze the relationship between patient-prosthesis mismatch (PPM) and in-hospital complications and mortality after aortic valve replacement (AVR)...
  74. doi Imaging decision-making for transfemoral or transapical approach of transcatheter aortic valve implantation
    Gerrit Kaleschke
    Adult Congenital and Valvular Heart Disease Center Muenster, Department of Cardiology and Angiology, University of Muenster, Muenster, Germany
    EuroIntervention 6:G20-7. 2010
    ..This article reviews the role of currently available imaging modalities for appropriate patient selection and decision between transfemoral and transapical approach...
  75. doi Hemodynamics and outcomes of aortic valve replacement with a 17- or 19-mm valve
    Homare Okamura
    Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama shi, Saitama, Japan
    Asian Cardiovasc Thorac Ann 18:450-5. 2010
    ..All patients improved to New York Heart Association functional class II or better. A small-sized prosthesis may provide satisfactory clinical and hemodynamic results in patients with a small aortic annulus...
  76. doi Aortic regurgitation after transcatheter aortic valve implantation: incidence and early outcome. Results from the German transcatheter aortic valve interventions registry
    Mohamed Abdel-Wahab
    Heart Center, Segeberger Kliniken GmbH, Bad Segeberg, Germany
    Heart 97:899-906. 2011
    ..Following transcatheter aortic valve implantation (TAVI), AR is common, but little is known about its determinants and its effect on clinical outcome...
  77. ncbi Enlargement of the small aortic root during aortic valve replacement: is there a benefit?
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 85:94-100. 2008
    ..To evaluate the risks and benefits of ARE, we examined the outcomes of patients with small aortic roots who underwent AVR with or without the use of ARE...
  78. doi Transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: results from the global valve-in-valve registry
    Danny Dvir
    Washington Hospital Center, 110 Irving St NW, Suite 4B 1, Washington, DC 20010, USA
    Circulation 126:2335-44. 2012
    ..We evaluated the clinical results of this technique using a large, worldwide registry...
  79. ncbi Aortic valve replacement with 17-mm St. Jude Medical prostheses for a small aortic root in elderly patients
    Tohru Takaseya
    Department of Cardiovascular Surgery, Clinical Research Institute, National Hospital Organization, Kyusyu Medical Center, Fukuoka, Japan
    Ann Thorac Surg 83:2050-3. 2007
    ..There are few reports about the optimal prosthesis for elderly patients who have small aortic roots with an aortic annular size of less than 19 mm...
  80. ncbi [Percutaneous aortic valve replacement - initial experience and results]
    Lene Kjaer Olsen
    Kardiologisk Klinik B 2014, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 171:1289-93. 2009
    ..The aim of this study was to evaluate the results of percutaneous aortic valve replacement - a new treatment modality for patients with inoperable AS...
  81. ncbi Multivariate analysis for operative mortality in obstructive prosthetic valve dysfunction due to pannus and thrombus formation
    Mehmet Erdem Toker
    Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, Turkey
    Int Heart J 47:237-45. 2006
    ..This study revealed that left ventricular dysfunction is the major determinant of surgical mortality in patients requiring reoperation for valve dysfunction due to pannus or thrombus...
  82. ncbi Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement
    W R E Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 129:1301-8. 2005
    ..The purpose of this study was to compare valve-related reoperation, morbidity (permanent impairment), and mortality between bioprostheses and mechanical prostheses for mitral valve replacement...
  83. ncbi Replacing the ascending aorta and aortic valve for acute prosthetic valve endocarditis: is using prosthetic material contraindicated?
    Christian Hagl
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York, USA
    Ann Thorac Surg 74:S1781-5; discussion S1792-9. 2002
    ..We report favorable results using this technique almost exclusively (a homograft was used in only 3 patients with hematological problems) during a 12-year interval...
  84. ncbi Postoperative coronary artery spasm complicating aortic valve replacement: implications for identification and treatment
    Claudio Pragliola
    Institute of Cardiac Surgery, Catholic University of Rome, Rome, Italy
    Ann Thorac Surg 83:670-2. 2007
    ..The spasm was demonstrated at coronary angiography and was resolved with the intracoronary infusion of nitrates and antiarrhythmics...
  85. pmc New percutaneous treatments for valve disease
    Louise Coats
    Great Ormond Street Hospital for Children, Great Ormond Street, London, UK
    Heart 93:639-44. 2007
  86. ncbi Mechanical heart valve cavitation
    Peter Johansen
    Department of Cardiothoracic and Vascular Surgery, Research Unit, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Expert Rev Med Devices 1:95-104. 2004
    ..Therefore, an applicable technique for in vivo detection of cavitation is required. This article reviews techniques developed for in vivo detection of cavitation and suggests focus for future studies...
  87. ncbi Factors influencing calcification of cardiac bioprostheses in adolescent sheep
    Willem Flameng
    Laboratory of Experimental Cardiac Surgery, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    J Thorac Cardiovasc Surg 132:89-98. 2006
    ..We determined the possible effects of age, antimineralization treatments, circulatory implant conditions, prosthesis design, and valve-related structural aspects on valve calcification in adolescent sheep...
  88. ncbi Spectral characteristics of mechanical heart valve closing sounds
    Peter Johansen
    Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital Skejby Sygehus, Denmark
    J Heart Valve Dis 11:736-44. 2002
    ..The study aim was to characterize the impact of the surrounding media on resonance frequency of a sound source, and to develop a method capable of evaluating the spectral characteristics of mechanical heart valves...
  89. ncbi The subcoronary Toronto stentless versus supra-annular Perimount stented replacement aortic valve: early clinical and hemodynamic results of a randomized comparison in 160 patients
    John B Chambers
    Valve Study Group, St Thomas Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 131:878-2. 2006
    ..The aim of this study was to compare early postoperative hemodynamic function and clinical events in a randomized, prospective series of 160 stentless and stented biological replacement aortic valves...
  90. ncbi Replacement of the systemic atrioventricular valve with a mechanical prosthesis in children aged less than 6 years: late clinical results of survival and subsequent replacement
    Kilian Ackermann
    Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University Munich, Munich, Germany
    J Thorac Cardiovasc Surg 134:750-6. 2007
    ..We analyzed the survival, clinical course, and role of prosthesis-patient mismatch after systemic atrioventricular valve replacement in children...
  91. ncbi Aortic valve replacement with the Sorin Pericarbon Freedom stentless prosthesis: 7 years' experience in 130 patients
    Augusto D'Onofrio
    Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy
    J Thorac Cardiovasc Surg 134:491-5. 2007
    ..The aim of this single-center retrospective study was to assess midterm clinical and hemodynamic results of aortic valve replacement with the Sorin Pericarbon Freedom stentless bioprosthesis...
  92. ncbi Are allografts the biologic valve of choice for aortic valve replacement in nonelderly patients? Comparison of explantation for structural valve deterioration of allograft and pericardial prostheses
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:558-564.e4. 2006
    ..To compare explantation for structural valve deterioration in nonelderly patients after aortic valve replacement with stented bovine pericardial and cryopreserved allograft valves...
  93. ncbi Are stentless valves superior to modern stented valves? A prospective randomized trial
    Ayyaz Ali
    Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, Cambridge, CB3 8RE, UK
    Circulation 114:I535-40. 2006
    ..It is presumed that stentless aortic bioprostheses are hemodynamically superior to stented bioprostheses. A prospective randomized controlled trial was undertaken to compare stentless versus modern stented valves...
  94. ncbi Stentless aortic valves as an alternative to homografts for valve replacement in active infective endocarditis complicated by ring abscess
    Henryk Siniawski
    Deutsches Herzzentrum Berlin, Berlin, Germany
    Ann Thorac Surg 75:803-8; discussion 808. 2003
    ..To avoid implantation of any prosthetic material, the Shelhigh No-React stentless valves and conduits may be considered an alternative when no suitable homograft is available...
  95. pmc Risk factors for pacemaker implantation following aortic valve replacement: a single centre experience
    G Limongelli
    Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy
    Heart 89:901-4. 2003
    ..To identify perioperative clinical predictors of permanent pacemaker implantation following aortic valve replacement...
  96. ncbi Normal values for Doppler echocardiographic assessment of heart valve prostheses
    Raphael Rosenhek
    Department of Cardiology, Vienna General Hospital, University of Vienna, Austria
    J Am Soc Echocardiogr 16:1116-27. 2003
    ..This study provides an updated overview on the available data of normal values to facilitate adequate interpretation of Doppler data...
  97. ncbi A new method for evaluation of cavitation near mechanical heart valves
    Peter Johansen
    Bioengineering Department, Penn State University, University Park, PA 16802, USA
    J Biomech Eng 125:663-70. 2003
    ..8806-0.9887). The new method showed that the cavitation signal could be extracted without a priori knowledge needed for setting the high-pass filter cut off frequency, nor did it introduce bandwidth limitation of the cavitation signal...
  98. doi Implantation of two self-expanding aortic bioprosthetic valves during the same procedure-Insights into valve-in-valve implantation ("Russian doll concept")
    Nicolo Piazza
    Interventional Cardiology Department, Erasmus MC, Thoraxcenter, Rotterdam, The Netherlands
    Catheter Cardiovasc Interv 73:530-9. 2009
    ..We discuss also the potential valve of on-line quantitative angiography for assessing the depth of valve implantation and the need to implant a second valve...
  99. doi Transcatheter aortic valve prosthesis surgically replaced 4 months after implantation
    Hans Gustav Thyregod
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Eur J Cardiothorac Surg 37:494-6. 2010
    ..We report the first case of surgical valve replacement in a patient with a dysfunctional transcatheter-implanted aortic valve prosthesis 4 months after implantation...
  100. doi Delayed dislocation of a transapically implanted aortic bioprosthesis
    Luis C Maroto
    Department of Cardiac Surgery, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Cardiothorac Surg 36:935-7. 2009
    ..We report the case of a delayed upward displacement of a prosthesis after this procedure. It is hypothesised that the asymmetric calcification of the native valve and the presence of a mitral prosthesis caused the dislocation...
  101. doi Electrocardiographic changes and clinical outcomes after transapical aortic valve implantation
    Marcos Gutierrez
    Quebec Heart and Lung Institute, Quebec, Quebec G1V 4G5, Canada
    Am Heart J 158:302-8. 2009
    ..The objective of our study was to determine the incidence, type, and timing of ECG changes associated with TAVI...

Research Grants84

  1. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2003
    ..To achieve these aims, it is proposed to use the most current techniques for measurement of tissue mechanical properties. ..
  2. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2007
    The goal of this proposal is to produce a fully characterized polyurethane heart valve prosthesis that will be ready for clinical evaluation. Existing replacement valves suffer from several shortcomings...
  3. DENTIN BIOMINERALIZATION
    Charles Sfeir; Fiscal Year: 2007
    ..This data will also provide basic knowledge for designing treatment of ectopic mineralization specifically in diseases as such kidney stones or failing heart valve prosthesis.
  4. Training in Biomechanics in Regenerative Medicine
    Michael Sacks; Fiscal Year: 2007
    ..Coursework includes intensive life science, and biomechanics is utilized to provide the students with a thorough grounding in both areas. Skills acquired in these courses are combined in later courses and the trainees' research. ..
  5. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2009
    ..It is envisioned that it will also facilitate the use of these devices for long term therapy by reducing the need for difficult pharmacological management with anticoagulants, which is mandated for most existing devices. ..
  6. Biomechanical optimization of TE heart valves
    Michael Sacks; Fiscal Year: 2007
    ..Specific Aim 3 - Evaluate the EPC-seeded ES-PEUU scaffold's ability to perform in-vivo using a single leaflet model. ..
  7. Biomechanical optimization of TE heart valves
    Michael Sacks; Fiscal Year: 2004
    ..3) Perform in-vitro evaluation of TEHV fabricated using optimal scaffold designs and 3D guided RV outflow track geometry using novel bioreactor loop imaging system. ..
  8. Biomechanical optimization of TE heart valves
    Michael S Sacks; Fiscal Year: 2010
    ..Specific Aim 3 - Evaluate the EPC-seeded ES-PEUU scaffold's ability to perform in-vivo using a single leaflet model. ..
  9. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael S Sacks; Fiscal Year: 2010
    ..Relevance to public health includes the develop of valved pulmonary conduits for the pediatric population that can grow with the patient, minimizing the need for continued re-operations to bring the patient to adulthood. ..
  10. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2007
    ..It is envisioned that it will also facilitate the use of these devices for long term therapy by reducing the need for difficult pharmacological management with anticoagulants, which is mandated for most existing devices. ..
  11. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  12. Mechanisms of In-Vivo Remodeling in Tissue Engineered Heart Valves
    Michael Sacks; Fiscal Year: 2007
    ..Relevance to public health includes the develop of valved pulmonary conduits for the pediatric population that can grow with the patient, minimizing the need for continued re-operations to bring the patient to adulthood. ..
  13. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2007
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  14. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2007
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  15. Translational studies in Heart Failure Gene Therapy
    Charles R Bridges; Fiscal Year: 2010
    ..Successful completion of this study may lead to alternatives to heart transplantation and permanent mechanical assist devices in the treatment of end stage heart failure. ..
  16. Translational studies in Heart Failure Gene Therapy
    Charles Bridges; Fiscal Year: 2009
    ..Successful completion of this study may lead to alternatives to heart transplantation and permanent mechanical assist devices in the treatment of end stage heart failure. ..
  17. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  18. Angiogenic tissue engineering to limit post-infarction ventricular remodeling
    Y Joseph Woo; Fiscal Year: 2010
    ....
  19. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  20. Tissue Engineered Nanofibrous Vascular Graft
    Song Li; Fiscal Year: 2009
    ..The accomplishment of this project will lead to the development of innovative technologies to engineer stem cells and nanofibrous scaffolds for the construction of small TEVGs. ..
  21. Mechanobiology of Mesenchymal Stem Cells
    Song Li; Fiscal Year: 2007
    ..g., using BMMSC-derived SMCs to construct tissue-engineered vascular grafts. ..
  22. Multipotent stem cells for tissue regeneration
    Song Li; Fiscal Year: 2010
    ..The accomplishment of this project will break new grounds of using iPS cells for regenerative medicine applications and establish novel technologies and cell sources for therapies. ..
  23. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2010
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
  24. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004
    ..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
  25. Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
    Clark T Hung; Fiscal Year: 2010
    ..The technology proposed in this application will facilitate engineering of large cartilage tissue constructs needed to resurface defects in OA joints. ..
  26. Pathophysiology/Clinical Outcomes/Patients/Endocarditis
    Christopher Cabell; Fiscal Year: 2005
    ..The findings of this study have implications not only for clinical care but will also provide a foundation of knowledge and network of investigators from which subsequent randomized trials can be conducted. ..
  27. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  28. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  29. Studies in pig-to-primate cardiac xenotransplantation
    CHRISTOPHER MC GREGOR; Fiscal Year: 2007
    ..In addition, by attempting to reverse rejection episodes with plasmapheresis we will identify the initiating mechanism of graft rejection. This proposal, if successful, lays the groundwork for the clinical application of cardiac XTx. ..
  30. GENETICS AND GENOMICS OF HUMAN DISEASE
    Richard Lifton; Fiscal Year: 2007
    ..Support is requested for 10 graduate students per year for a five-year period. ..
  31. BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
    Gerard Ateshian; Fiscal Year: 2007
    ..abstract_text> ..
  32. BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
    Gerard Ateshian; Fiscal Year: 2003
    ..05Mpa-5 Mpa, frequencies of 0.0005Hz - 0.5 Hz and up to 10 percent compressive strains, with and without enzymatic (collagenase, chondroitinase ABC and hyaluronidase) treatments. ..
  33. Anisotropy and Nonlinearity of Cartilage Mechanics
    Gerard Ateshian; Fiscal Year: 2007
    ..abstract_text> ..