heart valve prosthesis

Summary

Summary: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.

Top Publications

  1. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  2. ncbi Registry of transcatheter aortic-valve implantation in high-risk patients
    Martine Gilard
    Centre Hospitalier Universitaire CHU Brest, Brest, France
    N Engl J Med 366:1705-15. 2012
  3. ncbi Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis
    Corrado Tamburino
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Circulation 123:299-308. 2011
  4. ncbi Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) High Risk Study
    Patrick L Whitlow
    Cleveland Clinic, Ohio 44195, USA
    J Am Coll Cardiol 59:130-9. 2012
  5. ncbi One-year outcomes of cohort 1 in the Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) registry: the European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    Director of Cardiovascular Services, Cardiology Department, St Thomas Hospital, Westminster Bridge Rd, London, UK
    Circulation 124:425-33. 2011
  6. ncbi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
  7. ncbi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
  8. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
  9. ncbi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
  10. ncbi Transcatheter aortic valve implantation: 3-year outcomes of self-expanding CoreValve prosthesis
    Gian Paolo Ussia
    Interventional Structural and Congenital Heart Disease Programme, Invasive Cardiology Division of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy
    Eur Heart J 33:969-76. 2012

Research Grants

Detail Information

Publications279 found, 100 shown here

  1. ncbi Guidelines on the management of valvular heart disease: The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    Alec Vahanian
    Service de cardiologie, Hôpital Bichat AP HP, Paris, France
    Eur Heart J 28:230-68. 2007
  2. ncbi Registry of transcatheter aortic-valve implantation in high-risk patients
    Martine Gilard
    Centre Hospitalier Universitaire CHU Brest, Brest, France
    N Engl J Med 366:1705-15. 2012
    ..We report the results of a prospective multicenter study of the French national transcatheter aortic-valve implantation registry, FRANCE 2...
  3. ncbi Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis
    Corrado Tamburino
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Circulation 123:299-308. 2011
    ....
  4. ncbi Acute and 12-month results with catheter-based mitral valve leaflet repair: the EVEREST II (Endovascular Valve Edge-to-Edge Repair) High Risk Study
    Patrick L Whitlow
    Cleveland Clinic, Ohio 44195, USA
    J Am Coll Cardiol 59:130-9. 2012
    ....
  5. ncbi One-year outcomes of cohort 1 in the Edwards SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) registry: the European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    Director of Cardiovascular Services, Cardiology Department, St Thomas Hospital, Westminster Bridge Rd, London, UK
    Circulation 124:425-33. 2011
    ..Transcatheter aortic valve implantation was developed to provide a therapeutic option for patients considered to be ineligible for, and to mitigate mortality and morbidity associated with, high-risk surgical aortic valve replacement...
  6. ncbi Thirty-day results of the SAPIEN aortic Bioprosthesis European Outcome (SOURCE) Registry: A European registry of transcatheter aortic valve implantation using the Edwards SAPIEN valve
    Martyn Thomas
    St Thomas Hospital, London, UK
    Circulation 122:62-9. 2010
    ..The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008...
  7. ncbi Transcatheter aortic-valve replacement for inoperable severe aortic stenosis
    Raj R Makkar
    Cedars Sinai Heart Institute, Los Angeles, USA
    N Engl J Med 366:1696-704. 2012
    ..Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known...
  8. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported...
  9. ncbi Transcatheter aortic valve implantation: first results from a multi-centre real-world registry
    Ralf Zahn
    Abteilung fur Kardiologie, Herzzentrum Ludwigshafen, Bremserstrasse 79, Ludwigshafen, Germany
    Eur Heart J 32:198-204. 2011
    ..We report the first results of the prospective multi-centre German Transcatheter Aortic Valve Interventions-Registry...
  10. ncbi Transcatheter aortic valve implantation: 3-year outcomes of self-expanding CoreValve prosthesis
    Gian Paolo Ussia
    Interventional Structural and Congenital Heart Disease Programme, Invasive Cardiology Division of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy
    Eur Heart J 33:969-76. 2012
    ..We sought to assess 3-year clinical and echocardiographic outcomes of patients undergoing TAVI with the third generation CoreValve prosthesis (Medtronic Incorporation, MN, USA)...
  11. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    ....
  12. ncbi Diagnostic evaluation of left-sided prosthetic heart valve dysfunction
    Jesse Habets
    Department of Radiology, University Medical Center, Utrecht, P O Box 85500, 3508 GA, The Netherlands j habets umcutrecht nl
    Nat Rev Cardiol 8:466-78. 2011
    ..In this Review, we discuss the use of established imaging modalities for the detection of left-sided mechanical and biological PHV dysfunction and discuss the complementary role of MDCT in this context...
  13. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  14. ncbi Early experience with percutaneous transcatheter implantation of heart valve prosthesis for the treatment of end-stage inoperable patients with calcific aortic stenosis
    Alain Cribier
    Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen, France
    J Am Coll Cardiol 43:698-703. 2004
    ..This study was done to assess the results of percutaneous heart valve (PHV) implantation in non-surgical patients with end-stage calcific aortic stenosis...
  15. ncbi Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard
    I Chen Tsai
    Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Eur Radiol 19:857-67. 2009
    ..Except for images impaired by severe beam-hardening artifacts, MDCT provides excellent delineation of prosthetic valve disorders...
  16. pmc Prosthetic heart valve assessment with multidetector-row CT: imaging characteristics of 91 valves in 83 patients
    Jesse Habets
    Department of Radiology, UMC Utrecht, P O Box 85500, E01 132, 3508, GA, Utrecht, The Netherlands
    Eur Radiol 21:1390-6. 2011
    ..Multidetector CT (MDCT) has shown potential for prosthetic heart valve (PHV) assessment. We assessed the image quality of different PHV types to determine which valves are suitable for MDCT evaluation...
  17. ncbi Procedural, 30-day and one year outcome following CoreValve or Edwards transcatheter aortic valve implantation: results of the Belgian national registry
    Johan M Bosmans
    Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Antwerp, Belgium
    Interact Cardiovasc Thorac Surg 12:762-7. 2011
    ..This mid-term mortality was mainly related to age-related, non-cardiac complications...
  18. ncbi Patient-prosthesis mismatch does not affect survival following aortic valve replacement
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Cardiothorac Surg 30:10-4. 2006
    ..We analysed the effect of PPM at values predicting severe mismatch on survival following AVR in our unit...
  19. ncbi Immediate and late outcome of patients aged 80 years and older undergoing isolated aortic valve replacement: a systematic review and meta-analysis of 48 studies
    Francesco Vasques
    Department of Surgery, Oulu University Hospital, Oulu, Finland
    Am Heart J 163:477-85. 2012
    ..This study was planned to evaluate the outcome of patients ≥80 years old undergoing isolated conventional aortic valve replacement (AVR)...
  20. ncbi Beyond the short-term: clinical outcome and valve performance 2 years after transcatheter aortic valve implantation in 227 patients
    Sabine Bleiziffer
    Clinic for Cardiovascular Surgery, German Heart Center Munich, Germany
    J Thorac Cardiovasc Surg 143:310-7. 2012
    ..We report on 2-year follow-up clinical and echocardiographic results after transcatheter aortic valve implantation in 227 patients...
  21. ncbi Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (VARC-2)
    Arie Pieter Kappetein
    Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, Netherlands
    Eur J Cardiothorac Surg 42:S45-60. 2012
    ..In addition, this document is intended to expand the understanding of patient risk stratification and case selection...
  22. ncbi Trans-apical aortic valve implantation using a new self-expandable bioprosthesis: initial outcomes
    Jörg Kempfert
    Heartcenter University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 40:1114-9. 2011
    ..As an alternative device, a self-expanding sub-coronary trans-apical bioprosthesis was evaluated...
  23. pmc Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement
    Rodrigo Bagur
    Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada G1V 4G5
    Eur Heart J 31:865-74. 2010
    ..surgical aortic valve replacement (SAVR) in patients with pre-procedural chronic kidney disease (CKD)...
  24. ncbi Prosthesis-patient mismatch: an update
    Jean G Dumesnil
    Quebec Heart and Lung Institute, 2725 Chemin Sainte Foy, Quebec, Quebec, Canada G1V 4G5
    Curr Cardiol Rep 13:250-7. 2011
    ..Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation...
  25. pmc The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells
    Sharan Ramaswamy
    Cardiovascular Biomechanics Laboratory, Department of Bioengineering, Swanson School of Engineering, The McGowan Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 31:1114-25. 2010
    ....
  26. ncbi Aortic annulus evaluation in transcatheter aortic valve implantation
    Andrea Hutter
    Clinic for Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany
    Catheter Cardiovasc Interv 76:1009-19. 2010
    ..We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual-source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI)...
  27. pmc One year follow-up of the multi-centre European PARTNER transcatheter heart valve study
    Thierry Lefevre
    Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy, France
    Eur Heart J 32:148-57. 2011
    ..Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option in high-risk patients with severe aortic stenosis...
  28. ncbi Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve function
    Victoria Delgado
    Department of Cardiology and Cardiothoracic Surgery, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands
    Eur Heart J 31:1114-23. 2010
    ..However, the underlying mechanisms of this complication remain unclear. The present evaluation studied the anatomic and morphological features of the aortic valve annulus that may predict aortic regurgitation after TAVI...
  29. ncbi The role of ECG-gated MDCT in the evaluation of aortic and mitral mechanical valves: initial experience
    Eli Konen
    Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
    AJR Am J Roentgenol 191:26-31. 2008
    ..The objective of our study was to evaluate the role of ECG-gated MDCT in the functional evaluation of mechanical prosthetic aortic and mitral valves...
  30. ncbi Comparison of multidetector-row computed tomography to echocardiography and fluoroscopy for evaluation of patients with mechanical prosthetic valve obstruction
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken, Zwolle, The Netherlands
    Am J Cardiol 104:1128-34. 2009
    ..In conclusion, this initial experience demonstrates that multidetector-row computed tomography can identify causes of prosthetic valve obstruction that constitute indications for surgery but are missed at echocardiography or fluoroscopy...
  31. ncbi Ross operation with a tissue-engineered heart valve
    Pascal M Dohmen
    Department of Cardiovascular Surgery, Charite, Humboldt University Berlin, Germany
    Ann Thorac Surg 74:1438-42. 2002
    ..In this report a viable heart valve was created from decellularized cryopreserved pulmonary allograft that was seeded with viable autologous vascular endothelial cells (AVEC)...
  32. ncbi Multidetector-row computed tomography imaging characteristics of mechanical prosthetic valves
    Petr Symersky
    Department of Cardiothoracic Surgery, Isala Klinieken Zwolle, The Netherlands
    J Heart Valve Dis 20:216-22. 2011
    ..A pulsatile in vitro model was developed to study the MDCT imaging characteristics of mechanical heart valves (MHVs)...
  33. ncbi Cardiac valves in patients with Q fever endocarditis: microbiological, molecular, and histologic studies
    Hubert Lepidi
    Unite des Rickettsies, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6020, Institut Federatif de Recherche 48, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Infect Dis 187:1097-106. 2003
    ..Pathologic and immunohistochemical analyses may contribute to the diagnosis of Q fever endocarditis...
  34. ncbi Aortic stenosis
    Blase A Carabello
    Baylor College of Medicine, Department of Medicine and Veterans Affairs Medical Center, Houston, TX, USA
    Lancet 373:956-66. 2009
    ..We discuss these issues in this Review...
  35. ncbi Survival after transapical and transfemoral aortic valve implantation: talking about two different patient populations
    Sabine Bleiziffer
    Clinic for Cardiovascular Surgery, German Heart Center Munich, Lazarettstrasse 36, Munich, Germany
    J Thorac Cardiovasc Surg 138:1073-80. 2009
    ..We analyzed survival in patients undergoing transcatheter aortic valve implantation with special emphasis on the access site for implantation...
  36. ncbi Role of echocardiography in percutaneous aortic valve implantation
    Robert R Moss
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    JACC Cardiovasc Imaging 1:15-24. 2008
    ..This study was designed to investigate the usefulness and limitations of echocardiography in optimizing the outcome of percutaneous aortic valve implantation...
  37. doi 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to
    Robert O Bonow
    J Am Coll Cardiol 52:e1-142. 2008
  38. ncbi Prognostic significance of newly acquired bundle branch block after aortic valve replacement
    Ziad El-Khally
    Department of Cardiology, Montreal Heart Institute, Montreal, Quebec, Canada
    Am J Cardiol 94:1008-11. 2004
    ..A new and persistent BBB acquired after AVR is associated with an increased adverse event rate. This finding suggests that early prophylactic pacemaker implantation should be considered in these patients...
  39. ncbi Cardiac valvular surgery in dialysis patients: comparison of surgical outcome for mechanical versus bioprosthetic valves
    Kentaro Umezu
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, 162 8666, Japan
    Gen Thorac Cardiovasc Surg 57:197-202. 2009
    ..There has been a changing preference for bioprosthetic valves over mechanical valves in dialysis patients, but there is still much controversy. We reviewed our 17-year experience and assessed the influence of prosthesis choice...
  40. ncbi Hemodynamic results and changes in myocardial function after transcatheter aortic valve implantation
    Michael Gotzmann
    BG Kliniken Bergmannsheil, Medical Clinic II, Ruhr University Bochum, Germany
    Am Heart J 159:926-32. 2010
    ..This prospective study was designed to evaluate the hemodynamic results of transcatheter aortic valve implantation (TAVI) with the CoreValve prosthesis (Medtronic, Minneapolis, Minnesota) and the effects on left ventricular function...
  41. ncbi Enlargement of the small aortic root during aortic valve replacement: is there a benefit?
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 85:94-100. 2008
    ..To evaluate the risks and benefits of ARE, we examined the outcomes of patients with small aortic roots who underwent AVR with or without the use of ARE...
  42. ncbi Transcatheter aortic valve implantation through the ascending aorta: an alternative option for no-access patients
    Robert Bauernschmitt
    Clinic of Cardiovascular Surgery, The Technical University, Munich, Germany
    Heart Surg Forum 12:E63-4. 2009
    ..The ascending aorta approach might help to expand the implantation possibilities for those patients for whom the typical access sites are not available...
  43. ncbi Crimping may affect the durability of transcatheter valves: an experimental analysis
    Philipp Kiefer
    Department of Cardiac Surgery, Heart Center, Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    Ann Thorac Surg 92:155-60. 2011
    ..Transcatheter aortic valve implantation has gained widespread acceptance to treat elderly high-risk patients with aortic stenosis. We used a subcutaneous rat model to evaluate whether crimping may affect valve long-term durability...
  44. ncbi Transapical transcatheter aortic valve implantation using the JenaValve™ system: acute and 30-day results of the multicentre CE-mark study
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    Eur J Cardiothorac Surg 41:e131-8. 2012
    ..The system consists of a tested porcine root valve mounted on a nitinol stent with feeler-guided positioning and clip fixation on the diseased leaflets...
  45. ncbi Hemodynamics and outcomes of aortic valve replacement with a 17- or 19-mm valve
    Homare Okamura
    Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama shi, Saitama, Japan
    Asian Cardiovasc Thorac Ann 18:450-5. 2010
    ..All patients improved to New York Heart Association functional class II or better. A small-sized prosthesis may provide satisfactory clinical and hemodynamic results in patients with a small aortic annulus...
  46. ncbi Transfemoral aortic valve implantation new criteria to predict vascular complications
    Kentaro Hayashida
    Institut Cardiovasculaire Paris Sud, Massy, France
    JACC Cardiovasc Interv 4:851-8. 2011
    ..This study sought to evaluate the incidence, impact, and predictors of vascular complications in transcatheter aortic valve implantation (TAVI)...
  47. ncbi Defining patient-prosthesis mismatch and its effect on survival in patients with impaired ejection fraction
    David A Cotoni
    Department of Internal Medicine, Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Ann Thorac Surg 91:692-9. 2011
    ..How best to define patient-prosthesis mismatch (PPM) continues to be debated. Over time, the indexed effective orifice area has become the most widely used method. However, the clinical relevance of PPM remains controversial...
  48. ncbi Aortic root enlargement does not increase the surgical risk and short-term patient outcome?
    Gonçalo F Coutinho
    Cardiothoracic Surgery, University Hospital, Coimbra, Portugal
    Eur J Cardiothorac Surg 40:441-7. 2011
    ..To analyze the short-term outcome of aortic root enlargement (ARE) using death and adverse events as end points...
  49. ncbi Incidence and treatment of procedural cardiovascular complications associated with trans-arterial and trans-apical interventional aortic valve implantation in 412 consecutive patients
    Rüdiger Lange
    German Heart Center Munich, Munich, Germany
    Eur J Cardiothorac Surg 40:1105-13. 2011
    ..Herein, we report a complete, prospective analysis of complications occurring during transvascular and trans-apical implantations with two different prostheses...
  50. ncbi Effect of prosthesis-patient mismatch on long-term survival with aortic valve replacement: assessment to 15 years
    W R Eric Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    Ann Thorac Surg 89:51-8; discussion 59. 2010
    ..This study was performed to determine the predictors of mortality after aortic valve replacement and influence of prosthesis-patient mismatch on survival...
  51. ncbi Aortic valve replacement with 17-mm mechanical prostheses: is patient-prosthesis mismatch a relevant phenomenon?
    Andrea Garatti
    I Division of Cardiac Surgery, IRCCS Policlinico San Donato Hospital, San Donato Milanese, Milan, Italy
    Ann Thorac Surg 91:71-7. 2011
    ..We sought to evaluate the long-term performance of a consecutive cohort of patients implanted with a 17-mm bileaflet mechanical prosthesis...
  52. ncbi Transaortic Transcatheter Aortic valve implantation using Edwards Sapien valve: a novel approach
    Vinayak Bapat
    Department of Cardiothoracic Surgery, Guy s and St Thomas Hospital, London, United Kingdom
    Catheter Cardiovasc Interv 79:733-40. 2012
    ..To evaluate feasibility and outcome of Transoartic Transcatheter Sapien valve implantation...
  53. ncbi Health-related quality of life after transcatheter or surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results from the PARTNER (Placement of AoRTic TraNscathetER Valve) Trial (Cohort A)
    Matthew R Reynolds
    Harvard Clinical Research Institute, Boston VA Healthcare System, Boston, Massachusetts, USA
    J Am Coll Cardiol 60:548-58. 2012
    ....
  54. ncbi Implantation of the melody transcatheter pulmonary valve in patients with a dysfunctional right ventricular outflow tract conduit early results from the u.s. Clinical trial
    Evan M Zahn
    Miami Children s Hospital, Florida, USA
    J Am Coll Cardiol 54:1722-9. 2009
    ..Minneapolis, Minnesota) in patients with dysfunctional right ventricular outflow tract conduits...
  55. ncbi 2-year follow-up of patients undergoing transcatheter aortic valve implantation using a self-expanding valve prosthesis
    Lutz Buellesfeld
    Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland
    J Am Coll Cardiol 57:1650-7. 2011
    ..The purpose of this study was to evaluate the safety, device performance, and clinical outcome up to 2 years for patients undergoing transcatheter aortic valve implantation (TAVI)...
  56. ncbi Quality of life among patients undergoing transcatheter aortic valve implantation
    Markus Krane
    Department of Cardiovascular Surgery, German Heart Center Munich, Technische Universitat Munchen, Munich, Germany
    Am Heart J 160:451-7. 2010
    ..Especially in this subset of patients, the expected improvement of quality of life (QoL) after valve implantation will be critical for decision-making for TAVI...
  57. ncbi One-year results of transcatheter aortic valve implantation in severe symptomatic aortic valve stenosis
    Michael Gotzmann
    Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Bochum, Germany
    Am J Cardiol 107:1687-92. 2011
    ....
  58. ncbi Patient-prosthesis mismatch in patients with aortic stenosis undergoing isolated aortic valve replacement does not affect survival
    Neil J Howell
    Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Ann Thorac Surg 89:60-4. 2010
    ..Data suggest that patient-prosthesis mismatch (PPM) adversely effects late survival after aortic valve replacement (AVR). This study examined the incidence and implications of PPM in patients undergoing isolated AVR...
  59. ncbi Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitation
    Philip S Mullenix
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Valve Dis 17:666-9. 2008
    ..A bioprosthetic valve was installed and the patient recovered uneventfully. The diagnosis and surgical management of this problem are discussed...
  60. ncbi Valvular heart disease and pregnancy: part II: prosthetic valves
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    J Am Coll Cardiol 46:403-10. 2005
    ....
  61. ncbi Prosthesis-patient mismatch after aortic valve replacement: impact of age and body size on late survival
    Marc R Moon
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Thorac Surg 81:481-8; discussion 489. 2006
    ..The purpose of this study was to identify patient subgroups in which prosthesis-patient mismatch most influenced late survival...
  62. ncbi The impact of patient-prosthesis mismatch on late outcomes after mitral valve replacement
    Buu Khanh Lam
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 133:1464-73. 2007
    ..This study was conducted to determine the impact of patient-prosthesis mismatch on recurrent congestive heart failure, postoperative pulmonary hypertension, and late survival after mitral valve replacement...
  63. ncbi Anticoagulation in patients with mechanical valves during pregnancy
    Muhammad A Geelani
    Department of Cardiothoracic and Vascular Surgery, GB Pant Hospital, New Delhi 110002, India
    Asian Cardiovasc Thorac Ann 13:30-3. 2005
    ..We conclude that warfarin is safe and convenient to use during pregnancy. The teratogenic effects of warfarin during the 1(st) trimester are overstated, and switching to heparin is not mandatory...
  64. pmc A novel iterative reconstruction algorithm allows reduced dose multidetector-row CT imaging of mechanical prosthetic heart valves
    Jesse Habets
    Department of Radiology, University Medical Center Utrecht, PO Box 85500, E01 132, 3508 GA Utrecht, The Netherlands
    Int J Cardiovasc Imaging 28:1567-75. 2012
    ..5 ± 1.7 vs. 16.3 ± 1.6, mean ± SD, respectively, P = 1.0). IR allows ECG-gated PHV imaging with similar image noise and PHV artifacts at 50% less dose compared to conventional FBP in an pulsatile in vitro model...
  65. ncbi Calcification of tissue heart valve substitutes: progress toward understanding and prevention
    Frederick J Schoen
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, The Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 79:1072-80. 2005
    ....
  66. ncbi Frequency of conduction abnormalities after transcatheter aortic valve implantation with the Medtronic-CoreValve and the effect on left ventricular ejection fraction
    Apostolos Tzikas
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 107:285-9. 2011
    ..In conclusion, the induction of new conduction abnormalities after TAVI with the Medtronic-CoreValve was associated with a lack of improvement in LV systolic function...
  67. pmc Multidetector CT imaging of mechanical prosthetic heart valves: quantification of artifacts with a pulsatile in-vitro model
    Petr Symersky
    Department of Cardiothoracic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Eur Radiol 21:2103-10. 2011
    ..We quantified artifacts of four PHV using a pulsatile in-vitro model and assessed the relation to leaflet motion and valve design...
  68. ncbi Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve
    Nicolo Piazza
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    JACC Cardiovasc Interv 1:310-6. 2008
    ..In this retrospective study, we examined the incidence of post-procedural conduction abnormalities and the need for pacing in patients undergoing percutaneous implantation of the aortic valve...
  69. ncbi Choice of prosthetic heart valve for adult patients
    Shahbudin H Rahimtoola
    Griffith Center, Division of Cardiovascular Medicine, Department of Medicine, LAC USC Medical Center, Keck School of Medicine at the University of Southern California, 2025 Zonal Avenue, Los Angeles, CA 90033, USA
    J Am Coll Cardiol 41:893-904. 2003
    ..In individual patients there may be exceptions to these general rules...
  70. ncbi Treatment of destructive aortic valve endocarditis with the Freestyle Aortic Root Bioprosthesis
    Ludwig C Müller
    Department of Cardiac Surgery, University of Innsbruck, Innsbruck, Austria
    Ann Thorac Surg 75:453-6. 2003
    ..Homograft aortic roots are the conduits of choice, but because they are not available in all cases, alternative conduits are needed...
  71. doi Guidelines for reporting mortality and morbidity after cardiac valve interventions
    Cary W Akins
    The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 85:1490-5. 2008
  72. ncbi Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec, Canada
    J Thorac Cardiovasc Surg 132:401-6. 2006
    ..This study evaluates the mechanisms and clinical presentation of structural valve deterioration in the Freestyle stentless bioprosthesis...
  73. ncbi Early conduction disorders following percutaneous aortic valve replacement
    Valeria Calvi
    Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy
    Pacing Clin Electrophysiol 32:S126-30. 2009
    ..We examined the incidence and characteristics of CD in the immediate postoperative period after PAVR, and the need for permanent pacemaker (PPM) implantation...
  74. ncbi Vascular complications of transfemoral aortic valve implantation with the Edwards SAPIEN prosthesis: incidence and impact on outcome
    Gregory Ducrocq
    Department of Cardiology, Bichat Claude Bernard Hospital, Paris, France
    EuroIntervention 5:666-72. 2010
    ..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...
  75. ncbi Progress and current status of percutaneous aortic valve replacement: results of three device generations of the CoreValve Revalving system
    Eberhard Grube
    Departments of Cardiology, Cardiac Surgery, and Anaesthesiology, HELIOS Heart Center Siegburg, Ringstrasse 49, Siegburg, Germany
    Circ Cardiovasc Interv 1:167-75. 2008
    ..This study was intended to provide a summary of the development and current safety and efficacy status of the self-expanding CoreValve Revalving prosthesis...
  76. ncbi Long-term outcomes after isolated aortic valve replacement in octogenarians: a modern perspective
    Vinod H Thourani
    Clinical Research Unit, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 86:1458-64; discussion 1464-5. 2008
    ..This study compares the short- and long-term survival outcomes of octogenarians after AVR with younger age groups in the modern surgical era...
  77. ncbi Deleterious outcome of No-React-treated stentless valved conduits after aortic root replacement: why were warnings ignored?
    Thierry P Carrel
    Department of Cardiovascular Surgery, University Hospital, Berne, Switzerland
    J Thorac Cardiovasc Surg 136:52-7. 2008
    ....
  78. ncbi Unexpected complications of transapical aortic valve implantation
    Nawwar Al-Attar
    Department of Cardiovascular Surgery, Bichat Claude Bernard Hospital, Paris, France
    Ann Thorac Surg 88:90-4. 2009
    ..However, specific problems of this new procedure are not well-described. Unexpected complications due to the procedure and their management are reported...
  79. ncbi Long-term survival of dialysis patients in the United States with prosthetic heart valves: should ACC/AHA practice guidelines on valve selection be modified?
    Charles A Herzog
    Cardiovascular Special Studies Center, US Renal Data System, Department of Internal Medicine, Division of Cardiology, University of Minnesota, Minneapolis 55415, USA
    Circulation 105:1336-41. 2002
    ....
  80. ncbi Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement
    W R E Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 129:1301-8. 2005
    ..The purpose of this study was to compare valve-related reoperation, morbidity (permanent impairment), and mortality between bioprostheses and mechanical prostheses for mitral valve replacement...
  81. ncbi Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians
    James D Douketis
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Res 108:3-13. 2002
    ..The objectives of this review are to focus on practical issues relating to perioperative anticoagulation and the implementation of a perioperative anticoagulation management approach that can be used in everyday clinical practice...
  82. ncbi Prosthesis-patient mismatch predicts structural valve degeneration in bioprosthetic heart valves
    Willem Flameng
    Cardiac Surgery, University Clinic Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Circulation 121:2123-9. 2010
    ..However, it is unknown whether this can be related to future structural valve deterioration (SVD) of the bioprosthesis...
  83. ncbi Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography
    Arnold C T Ng
    Department of Cardiology, The Department of Cardiothoracic Surgery, and the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Circ Cardiovasc Imaging 3:94-102. 2010
    ..We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI)...
  84. ncbi The anti-calcification potential of a silsesquioxane nanocomposite polymer under in vitro conditions: potential material for synthetic leaflet heart valve
    Hossein Ghanbari
    Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Sciences, University College London, London, UK
    Acta Biomater 6:4249-60. 2010
    ..0001). These results indicate that the use of this nanocomposite in synthetic leaflets heart valves may lead to potential advantages in terms of long-term performances and durability...
  85. ncbi First report on a human percutaneous transluminal implantation of a self-expanding valve prosthesis for interventional treatment of aortic valve stenosis
    Eberhard Grube
    Department of Cardiology, Heart Center Siegburg, Siegburg, Germany
    Catheter Cardiovasc Interv 66:465-9. 2005
    ..7 cm2). Surgical valve replacement had been declined for the patient because of comorbidities, including previous bypass surgery...
  86. ncbi Anticoagulation in pregnant women with prosthetic heart valves
    Stephan Danik
    Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 71:322-9. 2004
    ..A discussion of the available data on anticoagulation in pregnant women with prosthetic heart valves is presented here, to inform the clinician and the patient of the risks and benefits of the options presently available...
  87. ncbi Routine enlargement of the small aortic root: a preventive strategy to minimize mismatch
    Luis J Castro
    Department of Cardiovascular Surgery, Sequoia Hospital, Redwood City, California, USA
    Ann Thorac Surg 74:31-6; discussion 36. 2002
    ..We routinely use aortic root enlargement (ARE) as part of one strategy to avoid prosthesis-patient mismatch in patients with relatively small aortic roots who are undergoing aortic valve replacement (AVR)...
  88. ncbi Does glutaraldehyde induce calcification of bioprosthetic tissues?
    A Vincentelli
    Department of Cardiovascular Surgery, Cardiologic Hospital, Lille, France
    Ann Thorac Surg 66:S255-8. 1998
    ..We investigated whether the origin of the tissue, autologous or heterologous, could have a more prominent role in the process of calcification...
  89. pmc PCR detection of bacteria on cardiac valves of patients with treated bacterial endocarditis
    Clarisse Rovery
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Hôpital dde la Timone, Marseille, France
    J Clin Microbiol 43:163-7. 2005
    ....
  90. ncbi Characterization of the immune response to valve bioprostheses and its role in primary tissue failure
    P Human
    Department of Cardiothoracic Surgery, Cape Heart Center, University of Cape Town Medical School, South Africa
    Ann Thorac Surg 71:S385-8. 2001
    ....
  91. ncbi Pregnancy outcome in women with prosthetic heart valves
    Anwar H Nassar
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon
    Am J Obstet Gynecol 191:1009-13. 2004
    ..This study was undertaken to evaluate the risks and pregnancy outcome in women with prosthetic heart valves on different anticoagulent regimens...
  92. ncbi Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II6-10. 1999
    ..The aim of this prospectively randomized study was to evaluate left ventricular hypertrophy and its regression after stentless versus conventional biological aortic valve replacement...
  93. ncbi Trans-apical aortic valve implantation: univariate and multivariate analyses of the early results from the SOURCE registry
    Olaf Wendler
    Department of Cardiothoracic Surgery, King s Health Partners, London, UK
    Eur J Cardiothorac Surg 38:119-27. 2010
    ..Currently, the results of trans-apical trans-catheter procedures performed outside controlled trials are unknown...
  94. ncbi Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement
    Thomas Walther
    Universitat Leipzig, Herzzentrum, Klinik fur Herzchirurgie, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 30:15-9. 2006
    ..The aim of this study was to evaluate the impact of patient prosthesis mismatch (PPM) and additional risk factors on outcome after aortic valve replacement (AVR)...
  95. ncbi Heart valve tissue engineering
    Ivan Vesely
    The Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine, University of Southern CaliforniaLos Angeles, CA 90027, USA
    Circ Res 97:743-55. 2005
    ..Alternative approaches to valvular tissue engineering, as well as the role of industry in shaping this field in the future, are also reviewed...
  96. pmc Short- and medium-term outcomes after transcatheter pulmonary valve placement in the expanded multicenter US melody valve trial
    Doff B McElhinney
    Department of Cardiology, Children s Hospital Boston, Boston, Mass 10032, USA
    Circulation 122:507-16. 2010
    ..The Melody valve was recently approved in the United States for placement in dysfunctional right ventricular outflow tract conduits...
  97. ncbi Percutaneous transarterial aortic valve implantation: what do we know?
    John Webb
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Heart J 32:140-7. 2011
    ..Nevertheless considerable work needs to be done before the indications for TAVI are expanded into lower risk groups. We review what is currently known about percutaneous transarterial implantation of the aortic valve...
  98. ncbi Minimally invasive versus standard approach aortic valve replacement: a study in 506 patients
    Ihsan Bakir
    Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
    Ann Thorac Surg 81:1599-604. 2006
    ..Minimally invasive aortic valve replacement through partial upper sternotomy has been shown to reduce surgical trauma, and, supposedly, decrease postoperative pain, blood loss, and hospital stay...
  99. ncbi Physiological consequences of percutaneous pulmonary valve implantation: the different behaviour of volume- and pressure-overloaded ventricles
    Louise Coats
    UCL Institute of Child Health, London, UK
    Eur Heart J 28:1886-93. 2007
    ..To investigate the early clinical and physiological consequences of relieving chronic right ventricular (RV) volume overload with percutaneous pulmonary valve implantation (PPVI)...
  100. ncbi Impact of prosthesis-patient mismatch on long-term survival after aortic valve replacement: influence of age, obesity, and left ventricular dysfunction
    Dania Mohty
    Laval Hospital Research Center Quebec Heart Institute, Laval University, Quebec, Quebec, Canada
    J Am Coll Cardiol 53:39-47. 2009
    ....
  101. ncbi Predictors for permanent pacemaker requirement after transcatheter aortic valve implantation with the CoreValve bioprosthesis
    Hasan Jilaihawi
    Glenfield Hospital, Leicester, United Kingdom
    Am Heart J 157:860-6. 2009
    ..We hypothesized that the need for PPM after CoreValve (Corevalve Inc, Irvine, CA) can be predicted with a combination of baseline variables...

Research Grants32

  1. Hyaluronan enhanced polymeric heart valve prosthesis
    Lakshmi Prasad Dasi; Fiscal Year: 2013
    ....
  2. A Novel Polymeric Percutaneous Heart Valve Prosthesis
    SCOTT C CORBETT; Fiscal Year: 2010
    ....
  3. Xenogeneic Scaffolds for Heart Valve Tissue Engineering
    LEIGH GARETH GRIFFITHS; Fiscal Year: 2013
    ..the National Heart Lung and Blood Institute (NHLBI) cardiac surgery working group to recommend support for heart valve prosthesis biomaterial research...
  4. DENTIN BIOMINERALIZATION
    Charles Sfeir; Fiscal Year: 2007
    ..This data will also provide basic knowledge for designing treatment of ectopic mineralization specifically in diseases as such kidney stones or failing heart valve prosthesis.
  5. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2004
    ..The goal of this Phase I project is the development of a trileaflet heart valve prosthesis with low trans-valve pressure loss...
  6. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2008
    ..provided by applicant): The goal of this proposal is to produce a fully characterized polyurethane heart valve prosthesis that will be ready for clinical evaluation. Existing replacement valves suffer from several shortcomings...
  7. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  8. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2008
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  9. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  10. Conference Support: The 13th International Drug Delivery Symposium
    David Grainger; Fiscal Year: 2007
    ..Support is requested both for selected speaker participation costs and 3 junior scientist poster travel awards. [unreadable] [unreadable] [unreadable]..
  11. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2008
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  12. Optimizing Cardiovascular Devices Thrombogenicity for Eliminating Anticoagulation
    Danny Bluestein; Fiscal Year: 2009
    ..It is envisioned that it will also facilitate the use of these devices for long term therapy by reducing the need for difficult pharmacological management with anticoagulants, which is mandated for most existing devices. ..
  13. Fatigue and Cytokines with Heart Failure
    Anne M Fink; Fiscal Year: 2010
    ..S., and fatigue is the most debilitating symptom associated with HF. Findings from the proposed study will contribute to the development of future interventions to manage fatigue in HF patients. ..
  14. Tissue Engineered Nanofibrous Vascular Graft
    Song Li; Fiscal Year: 2010
    ..The accomplishment of this project will lead to the development of innovative technologies to engineer stem cells and nanofibrous scaffolds for the construction of small TEVGs. ..
  15. Annular and Sub-Valvular Repair Techniques for Ischemic Mitral Regurgitation: In-
    Ajit P Yoganathan; Fiscal Year: 2010
    ..abstract_text> ..
  16. AVS Biomaterials Interface Division Technical Program Support
    David Grainger; Fiscal Year: 2006
    ..A number of relevant leading scientists and engineers from companies working in these technology areas are also recruited to participate using the new "Commercial Challenge" podium opportunity. [unreadable] [unreadable] [unreadable]..
  17. Molecular Comparison of Macrophage Foreign Body Response
    David Grainger; Fiscal Year: 2007
    ..abstract_text> ..
  18. PATHOBIOLOGY OF CEREBRAL CAVERNOUS MALFORMATION
    Richard Lifton; Fiscal Year: 2002
    ..They have established a collection of these lesions and have begun developing cell cultures of different cell lines from lesions in order to pursue this aim. ..
  19. Proteomic Profiling of Stem Cell Differentiation
    Song Li; Fiscal Year: 2005
    ..The successful accomplishment of the goals will have high impact on stem cell engineering, and provide a rational basis for engineering BMMSC for vascular tissue repair. ..
  20. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  21. World Workshop in Oral Medicine IV
    Peter Lockhart; Fiscal Year: 2005
    ..The proceedings will be published as evidence-based recommendations for best clinical practice in Oral Medicine as well as providing suggestions for future basic science and clinical research. ..
  22. Cardiac MR of Subclin CVD: Impact of Age
    WARREN MANNING; Fiscal Year: 2005
    ....
  23. SURFACE INFLUENCES ON CELL SIGNALING AND PROLIFERATION
    David Grainger; Fiscal Year: 2002
    ....
  24. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  25. Myocardial Gene Transfer during Cardiac Surgery in Swine
    Carmelo Milano; Fiscal Year: 2006
    ..These studies will help to develop safer and more efficient methods for gene delivery which can be coupled to cardiac surgery. As our knowledge advances, gene therapy may supplement established surgical treatments. ..
  26. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004
    ..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
  27. Mechanobiology of Mesenchymal Stem Cells
    Song Li; Fiscal Year: 2007
    ..g., using BMMSC-derived SMCs to construct tissue-engineered vascular grafts. ..
  28. Pathophysiology/Clinical Outcomes/Patients/Endocarditis
    Christopher Cabell; Fiscal Year: 2005
    ..The findings of this study have implications not only for clinical care but will also provide a foundation of knowledge and network of investigators from which subsequent randomized trials can be conducted. ..
  29. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  30. Extracellular Mechanisms For Thoracic Aortic Aneurysms
    John Ikonomidis; Fiscal Year: 2008
    ..abstract_text> ..
  31. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  32. Anisotropy and Nonlinearity of Cartilage Mechanics
    Gerard Ateshian; Fiscal Year: 2008
    ..abstract_text> ..