prostheses and implants

Summary

Summary: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.

Top Publications

  1. ncbi Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
    Mark S Humayun
    Doheny Retina Institute at the Doheny Eye Institute, University of Southern California, 1450 San Pablo Street Room 3600, Keck School of Medicine, Los Angeles, CA 14627, USA
    Vision Res 43:2573-81. 2003
  2. ncbi Neuronal ensemble control of prosthetic devices by a human with tetraplegia
    Leigh R Hochberg
    Department of Neurology, Massachusetts General Hospital, Brigham and Women s Hospital, and Spaulding Rehabilitation Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 442:164-71. 2006
  3. ncbi Intacs implantation using a femtosecond laser for management of keratoconus: Comparison of 306 cases in different stages
    Aylin Ertan
    Kudret Eye Hospital, Kennedy Caddesi No 71, Kavaklidere, Ankara, Turkey
    J Cataract Refract Surg 34:1521-6. 2008
  4. ncbi Correcting keratoconus with intracorneal rings
    J Colin
    Brest University Hospital, Brest, France
    J Cataract Refract Surg 26:1117-22. 2000
  5. ncbi A high-performance brain-computer interface
    Gopal Santhanam
    Department of Electrical Engineering, Stanford University, 330 Serra Mall, 319 Paul G Allen Center for Integrated Systems Annex, Stanford, California 94305 4075, USA
    Nature 442:195-8. 2006
  6. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement compared with circumferential arthrodesis for the treatment of two-level lumbar degenerative disc disease: res
    Rick Delamarter
    The Spine Institute at Saint John s Health Center, 1301 20th Street, Suite 400, Santa Monica, CA 90404, USA
    J Bone Joint Surg Am 93:705-15. 2011
  7. ncbi Long-term results following titanium cranioplasty of large skull defects
    Mario Cabraja
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Germany
    Neurosurg Focus 26:E10. 2009
  8. pmc Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants
    Yvonne Achermann
    Infectious Diseases Service, Department of Internal Medicine, Cantonal Hospital Zug, Baar, Switzerland
    J Clin Microbiol 48:1208-14. 2010
  9. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part I: evaluation of clinical outcomes
    Scott Blumenthal
    Texas Back Institute, Plano, Texas 75093, USA
    Spine (Phila Pa 1976) 30:1565-75; discussion E387-91. 2005
  10. ncbi Results from the multicenter Boston Type 1 Keratoprosthesis Study
    Brian L Zerbe
    Albany Medical College, Albany, New York, USA
    Ophthalmology 113:1779.e1-7. 2006

Detail Information

Publications385 found, 100 shown here

  1. ncbi Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
    Mark S Humayun
    Doheny Retina Institute at the Doheny Eye Institute, University of Southern California, 1450 San Pablo Street Room 3600, Keck School of Medicine, Los Angeles, CA 14627, USA
    Vision Res 43:2573-81. 2003
    ..In addition, the subject was able to use a camera to detect the presence or absence of ambient light, to detect motion, and to recognize simple shapes...
  2. ncbi Neuronal ensemble control of prosthetic devices by a human with tetraplegia
    Leigh R Hochberg
    Department of Neurology, Massachusetts General Hospital, Brigham and Women s Hospital, and Spaulding Rehabilitation Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 442:164-71. 2006
    ..These early results suggest that NMPs based upon intracortical neuronal ensemble spiking activity could provide a valuable new neurotechnology to restore independence for humans with paralysis...
  3. ncbi Intacs implantation using a femtosecond laser for management of keratoconus: Comparison of 306 cases in different stages
    Aylin Ertan
    Kudret Eye Hospital, Kennedy Caddesi No 71, Kavaklidere, Ankara, Turkey
    J Cataract Refract Surg 34:1521-6. 2008
    ..To evaluate the efficacy of intrastromal ring segment (Intacs, Addition Technology, Inc.) implantation and analyze outcomes according to different keratoconus stages...
  4. ncbi Correcting keratoconus with intracorneal rings
    J Colin
    Brest University Hospital, Brest, France
    J Cataract Refract Surg 26:1117-22. 2000
    ..To evaluate the potential of intrastromal corneal ring technology (Intacs, KeraVision) to correct keratoconus without central corneal scarring...
  5. ncbi A high-performance brain-computer interface
    Gopal Santhanam
    Department of Electrical Engineering, Stanford University, 330 Serra Mall, 319 Paul G Allen Center for Integrated Systems Annex, Stanford, California 94305 4075, USA
    Nature 442:195-8. 2006
    ..These performance results and their implications for system design should substantially increase the clinical viability of BCIs in humans...
  6. ncbi Prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement compared with circumferential arthrodesis for the treatment of two-level lumbar degenerative disc disease: res
    Rick Delamarter
    The Spine Institute at Saint John s Health Center, 1301 20th Street, Suite 400, Santa Monica, CA 90404, USA
    J Bone Joint Surg Am 93:705-15. 2011
    ....
  7. ncbi Long-term results following titanium cranioplasty of large skull defects
    Mario Cabraja
    Department of Neurosurgery, Charite Universitatsmedizin Berlin, Germany
    Neurosurg Focus 26:E10. 2009
    ..In this retrospective study of large skull defects, the authors compared computer-assisted design/computer-assisted modeled (CAD/CAM) titanium implants for cranioplasty with other frequently used materials described in literature...
  8. pmc Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants
    Yvonne Achermann
    Infectious Diseases Service, Department of Internal Medicine, Cantonal Hospital Zug, Baar, Switzerland
    J Clin Microbiol 48:1208-14. 2010
    ..With modified primer sets, multiplex PCR has the potential for further improvement of the diagnosis of PJI...
  9. ncbi A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: part I: evaluation of clinical outcomes
    Scott Blumenthal
    Texas Back Institute, Plano, Texas 75093, USA
    Spine (Phila Pa 1976) 30:1565-75; discussion E387-91. 2005
    ..A prospective, randomized, multicenter, Food and Drug Administration-regulated Investigational Device Exemption clinical trial...
  10. ncbi Results from the multicenter Boston Type 1 Keratoprosthesis Study
    Brian L Zerbe
    Albany Medical College, Albany, New York, USA
    Ophthalmology 113:1779.e1-7. 2006
    ..To report indications, practices, complications, and outcomes from the first multicenter study on the Boston Type 1 keratoprosthesis...
  11. ncbi Mediation of biomaterial-cell interactions by adsorbed proteins: a review
    Cameron J Wilson
    Tissue BioRegeneration Domain, Institute of Health and Biomedical Innovation, School of Engineering Systems, Queensland University of Technology, Brisbane, Queensland, Australia
    Tissue Eng 11:1-18. 2005
    ..Hence, one of the key issues yet to be resolved is that of the interface composition actually encountered by osteoblasts within the sequence of inflammation and bone regeneration...
  12. ncbi INTACS inserts for treating keratoconus: one-year results
    J Colin
    Bordeaux University Hospital, Hopital Pellegrin, Bordeaux, France
    Ophthalmology 108:1409-14. 2001
    ..The corneal steepening and astigmatism associated with keratoconus were reduced, and visual acuity was improved with treatment in almost all eyes...
  13. ncbi Comparison of single-segment and double-segment Intacs for keratoconus and post-LASIK ectasia
    Munish Sharma
    Boxer Wachler Vision Institute, 465 North Roxbury Drive, Beverly Hills, CA 90210, USA
    Am J Ophthalmol 141:891-5. 2006
    ..To evaluate the efficacy of single-segment Intacs and compare with double-segment Intacs in subjects with post-LASIK ectasia and keratoconus...
  14. ncbi The significance of infection related to orthopedic devices and issues of antibiotic resistance
    Davide Campoccia
    Research Unit on Implant Infections, Rizzoli Orthopedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomaterials 27:2331-9. 2006
    ....
  15. ncbi Intracorneal rings for keratoconus and keratectasia
    Aylin Ertan
    Kudret Eye Hospital, Ankara, Turkey, and the Bordeaux University, Bordeaux, France
    J Cataract Refract Surg 33:1303-14. 2007
    ..This article reviews the latest data published or presented at meetings on the correction of keratoconus and keratectasia by intracorneal ring segments...
  16. ncbi Fabrication methods of porous metals for use in orthopaedic applications
    Garrett Ryan
    National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
    Biomaterials 27:2651-70. 2006
    ..This review summarises all known methods for fabricating such porous metallic scaffolds...
  17. ncbi Bayesian population decoding of motor cortical activity using a Kalman filter
    Wei Wu
    Division of Applied Mathematics, Brown University, Providence, RI 02912, USA
    Neural Comput 18:80-118. 2006
    ..Additionally the formulation unifies and extends previous models of neural coding while providing insights into the motor-cortical code...
  18. pmc Biomaterials in orthopaedics
    M Navarro
    Biomaterials, Implants and Tissue Engineering, Institute for Bioengineering of Catalonia IBEC, CIBER BBN, 08028 Barcelona, Spain
    J R Soc Interface 5:1137-58. 2008
    ..In this review, the evolution of different metals, ceramics and polymers most commonly used in orthopaedic applications is discussed, as well as the different approaches used to fulfil the challenges faced by this medical field...
  19. pmc Interspinous implants (X Stop, Wallis, Diam) for the treatment of LSS: is there a correlation between radiological parameters and clinical outcome?
    Rolf Sobottke
    Department of Orthopaedic and Trauma Surgery, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
    Eur Spine J 18:1494-503. 2009
    ..The interspinous implant offers significant, longlasting symptom control, even if initially significant radiological changes seem to revert toward the initial values ("loss of correction")...
  20. ncbi Intacs in advanced keratoconus
    Rohit Shetty
    Cornea and Refractive Surgery Service, Narayana Nethralaya, Postgraduate Institute of Ophthalmology, Bangalore, India
    Cornea 27:1022-9. 2008
    ..To evaluate the surgical outcomes of microthin intracorneal ring segment (INTACS) implantation in advanced keratoconus...
  21. pmc Implant healing in experimental animal models of diabetes
    Nga N Le
    Division of Plastic, Reconstructive, Maxillofacial and Oral Surgery, Kenan Plastic Surgery Research Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    J Diabetes Sci Technol 5:605-18. 2011
    ....
  22. ncbi Correction of presbyopia with a small aperture corneal inlay
    George O Waring
    Revision Advanced Laser Eye Center, Columbus, Ohio 43240, USA
    J Refract Surg 27:842-5. 2011
    ..To assess the efficacy of a small aperture corneal inlay (KAMRA, AcuFocus Inc) to improve near vision in emmetropic presbyopes...
  23. ncbi High surface energy enhances cell response to titanium substrate microstructure
    G Zhao
    Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Biomed Mater Res A 74:49-58. 2005
    ..This suggests that increased bone formation observed on modified Ti surfaces in vivo is due in part to stimulatory effects of high surface energy on osteoblasts...
  24. ncbi One-year visual outcomes and patient satisfaction after surgical correction of presbyopia with an intracorneal inlay of a new design
    Alois K Dexl
    University Eye Clinic, Paracelsus Medical University, Salzburg, Austria
    J Cataract Refract Surg 38:262-9. 2012
    ..To evaluate the safety and efficacy of the third-generation Kamra corneal inlay (ACI 7000PDT) implanted monocularly in corneal pockets of emmetropic presbyopic patients to improve near and intermediate vision...
  25. ncbi Intracorneal ring segment implantation for the management of keratoconus: safety and efficacy
    Mohammad A Zare
    Department of Ophthalmology and Ophthalmic Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Cataract Refract Surg 33:1886-91. 2007
    ..To assess the safety and efficacy of intracorneal ring segment (Intacs, Addition Technology, Inc.) implantation in the management of keratoconus...
  26. ncbi Optical modeling of a corneal inlay in real eyes to increase depth of focus: optimum centration and residual defocus
    Juan Tabernero
    Laboratorio de Optica, Universidad de Murcia, Murcia, Spain
    J Cataract Refract Surg 38:270-7. 2012
    ..To determine the optimum position to center a small-aperture corneal inlay and the effect of residual defocus in the surgical eye to maximize depth of focus...
  27. ncbi Modified intracorneal ring segment implantations (INTACS) for the management of moderate to advanced keratoconus: efficacy and complications
    A John Kanellopoulos
    Department of Ophthalmology, New York University Medical School, New York, New York, USA
    Cornea 25:29-33. 2006
    ..To evaluate the safety and efficacy of modified intracorneal ring segment implantation (INTACS) in the management of moderate and advanced keratoconus (KCN)...
  28. pmc Cemented, cementless, and hybrid prostheses for total hip replacement: cost effectiveness analysis
    Mark Pennington
    Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London WC1H 9SH, UK
    BMJ 346:f1026. 2013
    ..To compare the cost effectiveness of the three most commonly chosen types of prosthesis for total hip replacement...
  29. ncbi X-stop versus decompressive surgery for lumbar neurogenic intermittent claudication: randomized controlled trial with 2-year follow-up
    Björn H Strömqvist
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Skane University Hospital, Malmo, Sweden
    Spine (Phila Pa 1976) 38:1436-42. 2013
    ..Prospective randomized controlled study...
  30. ncbi The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel
    Yi Liu
    Shandong Provincial Laboratory of Oral Biomedicine, School and Hospital of Stomatology, Shandong University, Jinan, Shandong 250012, PR China
    Biomaterials 33:8745-56. 2012
    ..Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery...
  31. pmc Infection of orthopedic implants with emphasis on bacterial adhesion process and techniques used in studying bacterial-material interactions
    Marta Ribeiro
    Instituto de Engenharia Biomedica, Universidade do Porto, Porto, Portugal
    Biomatter 2:176-94. 2012
    ....
  32. ncbi Binocular visual simulation of a corneal inlay to increase depth of focus
    Juan Tabernero
    Laboratorio de Optica, Universidad de Murcia, Campus de Espinardo, Murcia, Spain
    Invest Ophthalmol Vis Sci 52:5273-7. 2011
    ..To investigate binocular visual acuity and depth of focus when one eye forms images through a typical pupil diameter aperture (4 mm) and the other eye through a small pupil of 1.5-mm diameter...
  33. ncbi Evaluation of the stability of Boston type I keratoprosthesis-donor cornea interface using anterior segment optical coherence tomography
    Julian P S Garcia
    The New York Eye and Ear Infirmary, New York, USA
    Cornea 29:1031-5. 2010
    ..The presence of a gap would raise concerns of a possible pathway for the exchange of extraocular fluid with the anterior chamber...
  34. ncbi Microbial keratitis after intrastromal corneal ring segment implantation
    M Emilia Mulet
    Department of Ophthalmology, Miguel Hernandez University, Alicante, Spain
    J Refract Surg 26:364-9. 2010
    ..To evaluate the incidence of acute microbial keratitis after intrastromal corneal ring segment implantation and to investigate whether microbial keratitis is related to the intrastromal corneal ring type or surgical technique...
  35. ncbi Customised fabricated implants after previous failed cranioplasty
    Raymond C W Goh
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu Shin Street, Kwei Shan, Taoyuan 333, Taiwan
    J Plast Reconstr Aesthet Surg 63:1479-84. 2010
    ..Customised fabricated alloplastic implants provide a safe, accurate and efficient way of restoring normal cranial contours in patients with cranial defects who have had previous failed cranioplasties...
  36. ncbi Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis
    A M Meehan
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Clin Infect Dis 36:845-9. 2003
    ..For patients who present with a well-fixed prosthesis and a short duration of symptoms, debridement with retention appears to be an effective treatment modality...
  37. ncbi Antibacterial coatings on titanium implants
    Lingzhou Zhao
    School of Stomatology, The Fourth Military Medical University, Xi an 710072, People s Republic of China
    J Biomed Mater Res B Appl Biomater 91:470-80. 2009
    ..One important strategy is to render the implant surface antibacterial by impeding the formation of a biofilm. A number of approaches have been proposed for this purpose and they are reviewed in this article...
  38. ncbi Artificial anal sphincter: complications and functional results of a large personal series
    Jose M Devesa
    Division of Colon and Rectal Surgery, University Hospital Ramon y Cajal, Madrid, Spain
    Dis Colon Rectum 45:1154-63. 2002
    ....
  39. ncbi Biofunctionalization of biomaterials for accelerated in situ endothelialization: a review
    Achala de Mel
    Centre of Nanotechnology, Biomaterials and Tissue Engineering, UCL Division of Surgery and Interventional Science, University College London, London, United Kingdom
    Biomacromolecules 9:2969-79. 2008
    ..EC and EPC interactions with the extracellular matrix continue to be a principal source of inspiration for material biofunctionalization, and therefore, the latest developments in understanding these interactions will be discussed...
  40. ncbi Antibiotic resistance in exopolysaccharide-forming Staphylococcus epidermidis clinical isolates from orthopaedic implant infections
    Carla Renata Arciola
    Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 26:6530-5. 2005
    ..Moreover, multiple resistance to antibiotics was more frequent among exopolysaccharide-forming strains...
  41. ncbi A multicenter, prospective, randomized trial evaluating the X STOP interspinous process decompression system for the treatment of neurogenic intermittent claudication: two-year follow-up results
    James F Zucherman
    St Mary s Hospital, San Francisco, California, USA
    Spine (Phila Pa 1976) 30:1351-8. 2005
    ..A randomized, controlled, prospective multicenter trial comparing the outcomes of neurogenic intermittent claudication (NIC) patients treated with the interspinous process decompression system (X STOP) with patients treated nonoperatively...
  42. ncbi A multiaxial force-sensing implantable tibial prosthesis
    Bryan Kirking
    Orthopaedic Research Laboratories, Shiley Center for Orthopaedic Research and Education at Scripps Clinic, CA, USA
    J Biomech 39:1744-51. 2006
    ..Additional uses are intraoperative measurement of forces to determine soft-tissue balancing and to evaluate the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living...
  43. ncbi Intacs insertion with the femtosecond laser for the management of keratoconus: one-year results
    Aylin Ertan
    Kudret Eye Hospital, Ankara, Turkey
    J Cataract Refract Surg 32:2039-42. 2006
    ..To assess the outcomes of intrastromal ring segment (Intacs, Addition Technology) implantation for keratoconus using the femtosecond laser...
  44. pmc Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication
    Kerryl E Piper
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First St S W, Rochester, MN 55905, USA
    J Clin Microbiol 47:1878-84. 2009
    ..9%) and sonicate fluid culture (40.9%). All subjects from whom P. acnes was isolated from sonicate fluid were male. We conclude that sonicate fluid culture is useful for the diagnosis of prosthetic shoulder infection...
  45. ncbi Late bacterial keratitis after implantation of intrastromal corneal ring segments
    Tristan Bourcier
    Quinze Vingts National Center of Ophthalmology, Paris, France
    J Cataract Refract Surg 29:407-9. 2003
    ..The infiltrates progressed despite treatment with topical fortified and systemic antibiotics. The Intacs were removed. The keratitis slowly resolved, and the patient recovered a best corrected visual acuity of 20/20...
  46. ncbi Low stiffness porous Ti structures for load-bearing implants
    B Vamsi Krishna
    W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Acta Biomater 3:997-1006. 2007
    ..to reduce effective stiffness for load-bearing implants. Young's modulus and 0.2% proof strength of these porous Ti samples having 35-42vol.% porosity are found to be similar to those of human cortical bone...
  47. ncbi Advances in Boston keratoprosthesis: enhancing retention and prevention of infection and inflammation
    Bilal F Khan
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, MA 02114, USA
    Int Ophthalmol Clin 47:61-71. 2007
  48. ncbi Taylored implants for alloplastic cranioplasty--clinical and surgical considerations
    B Hoffmann
    Neurosurgical Clinic, Clemenshospital Münster, Germany
    Acta Neurochir Suppl 93:127-9. 2005
    ..Application of this technique is limited by cost, nonetheless it is recommended for extensive reconstruction of the skull...
  49. ncbi The Otto Aufranc Award: bone augmentation around and within porous implants by local bisphosphonate elution
    Michael Tanzer
    Department of Surgery, McGill University, Montreal, Quebec, Canada
    Clin Orthop Relat Res 441:30-9. 2005
    ..The concept represents a potential tool for restoration of bone stock and enhancement of implant fixation in primary and revision cementless joint arthroplasty surgeries in the face of compromised or deficient bone...
  50. ncbi Computer aided design of large-format prefabricated cranial plates
    David Dean
    Department of Neurological Surgery and the Research Institute, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Craniofac Surg 14:819-32. 2003
    ..Therefore, the authors conclude that their new production method provides a better result with less expense than current methods for preoperative or intraoperative fabrication of large-format cranioplasties...
  51. ncbi The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles
    Katrin Lochner
    Department of Orthopaedics, University of Rostock, D 18057 Rostock, Germany
    Int J Mol Med 28:1055-63. 2011
    ..Among the reference particles, which caused less altered reactions in the metabolism of osteoblasts in general, ZrO2 can be assumed as the material with the smallest cell biological effects...
  52. ncbi BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model
    Y Liu
    Biomaterials Research Group, Twente University, Enschede, The Netherlands
    Bone 36:745-57. 2005
    ..Using a rat model, we evaluated the kinetics and histomorphometry of ectopic bone formation in association with biomimetic implant coatings containing BMP-2...
  53. ncbi Silver-coated megaendoprostheses in a rabbit model--an analysis of the infection rate and toxicological side effects
    Georg Gosheger
    Department of Orthopedics, University of Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    Biomaterials 25:5547-56. 2004
    ....
  54. ncbi Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Med 118:1416. 2005
    ..aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses...
  55. ncbi Overcoming artifacts from metallic orthopedic implants at high-field-strength MR imaging and multi-detector CT
    Mi Jung Lee
    Department of Diagnostic Radiology and Research Institute of Radiological Science and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 134 Sincheon Dong Seodaemun Gu, Seoul 120 752, Republic of Korea
    Radiographics 27:791-803. 2007
    ..A comparison of images obtained with different hardware and different acquisition and reconstruction parameters facilitates an understanding of methods for reducing or overcoming artifacts related to metallic implants...
  56. ncbi Boston keratoprosthesis outcomes and complications
    Hall F Chew
    Cornea Service, Wills Eye Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    Cornea 28:989-96. 2009
    ..To evaluate the outcomes of the Boston Keratoprosthesis (KPro) at our institution...
  57. ncbi Vestibular prostheses: the engineering and biomedical issues
    C Wall
    Harvard Medical School, Department of Otology and Laryngology, Boston, MA 02114, USA
    J Vestib Res 12:95-113. 2002
    ..In this "white paper", we consider these issues in the context of prototype baseline prosthetic devices...
  58. ncbi Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study
    Thomas Jakobsen
    Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Norrebrogade 44, Bldg 1A, DK 8000 Aarhus C, Denmark
    J Orthop Res 25:432-41. 2007
    ..3-fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown...
  59. ncbi Direct cortical control of 3D neuroprosthetic devices
    Dawn M Taylor
    Department of Bioengineering, Arizona State University, Tempe, AZ 85287 6006, USA
    Science 296:1829-32. 2002
    ..By using control algorithms that track these changes, subjects made long sequences of 3D movements using far fewer cortical units than expected. Daily practice improved movement accuracy and the directional tuning of these units...
  60. ncbi Nanostructured materials for inhibition of bacterial adhesion in orthopedic implants: a minireview
    L Montanaro
    Research Unit on Implant Infections, Rizzoli Orthopedic Institute, Bologna and Department of Experimental Pathology of the University of Bologna, Bologna Italy
    Int J Artif Organs 31:771-6. 2008
    ..This minireview discusses studies on nanophase materials as bone implants, focusing on the effect of these materials in inhibiting bacterial adhesion for the prevention of implant infections...
  61. ncbi Biofilm formation and composition on different implant materials in vivo
    A Al-Ahmad
    Department of Operative Dentistry and Periodontology, Albert Ludwigs University, 79106 Freiburg, Germany
    J Biomed Mater Res B Appl Biomater 95:101-9. 2010
    ..were also detected. No significant differences in biofilm composition on the implant surfaces could be observed. In total, the influence of roughness and material on biofilm formation was compensated by biofilm maturation...
  62. ncbi Functional electrical stimulation for neuromuscular applications
    P Hunter Peckham
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Annu Rev Biomed Eng 7:327-60. 2005
    ....
  63. pmc Porous tantalum structures for bone implants: fabrication, mechanical and in vitro biological properties
    Vamsi Krishna Balla
    WM Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Acta Biomater 6:3349-59. 2010
    ..Our results show that these laser-processed porous Ta structures can find numerous applications, particularly among older patients, for metallic implants because of their excellent bioactivity...
  64. ncbi Intrastromal corneal ring segment SK implantation for moderate to severe keratoconus
    Wiwan Sansanayudh
    Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Ontario, Canada
    J Cataract Refract Surg 36:110-3. 2010
    ..To report the efficacy and safety of intrastromal corneal ring segment (ICRS) implantation using a femtosecond laser in the management of advanced keratoconus...
  65. ncbi Visual outcomes and safety of a refractive corneal inlay for presbyopia using femtosecond laser
    Aliki N Limnopoulou
    Department of Opthalmology, Vardinoyannion Eye Institute of Crete, Crete, Greece
    J Refract Surg 29:12-8. 2013
    ..To evaluate the outcomes and safety of a refractive inlay (Flexivue Micro-Lens, Presbia Coöperatief U.A.) for the corneal compensation of presbyopia...
  66. pmc Influence of feedback parameters on performance of a vibrotactile balance prosthesis
    Adam D Goodworth
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    IEEE Trans Neural Syst Rehabil Eng 17:397-408. 2009
    ..6 Hz. Finally, we created a postural model that accounted for the experimental results and gave insight into how vibrotactile information was incorporated into the postural control system...
  67. ncbi Intrastromal corneal ring segments for advanced keratoconus and cases with high keratometric asymmetry
    Mohammad I Khan
    Singleton Hospital Abertawe Bro Morgannwg University NHS Trust, Swansea, United Kingdom
    J Cataract Refract Surg 38:129-36. 2012
    ..To report the safety and efficacy of intrastromal corneal ring segment (ICRS) implantation to manage keratoconus...
  68. ncbi Short-term cell death and inflammation after intracorneal inlay implantation in rabbits
    Marcony R Santhiago
    The Cole Eye Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Refract Surg 28:144-9. 2012
    ..To investigate the cell death and inflammatory response to insertion of the KAMRA inlay (AcuFocus Inc) for presbyopia...
  69. ncbi Classification of osseointegrated implant surfaces: materials, chemistry and topography
    David M Dohan Ehrenfest
    Department of Biomaterials, Institute for Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Trends Biotechnol 28:198-206. 2010
    ..This standardized classification system will allow to clarify unambiguously the identity of any given osseointegrated surface and help to identify the biological outcomes of each surface characteristic...
  70. ncbi One-year safety and efficacy results of a hydrogel inlay to improve near vision in patients with emmetropic presbyopia
    Enrique Barragan Garza
    Laser Ocular hidalgo, Nuevo Leone, Mexico
    J Refract Surg 29:166-72. 2013
    ..To conduct a feasibility study of the safety and efficacy of a corneal contouring inlay as a treatment for emmetropic presbyopia...
  71. ncbi Effect of age on outcomes in patients with keratoconus treated by Intacs using a femtosecond laser
    Aylin Ertan
    Kudret Eye Hospital, Ankara, Turkey
    J Refract Surg 24:690-5. 2008
    ..To compare the response to Intacs treatment in different age groups of patients with keratoconus...
  72. pmc Effectiveness of interspinous implant surgery in patients with intermittent neurogenic claudication: a systematic review and meta-analysis
    Wouter A Moojen
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    Eur Spine J 20:1596-606. 2011
    ..The main objective of this review was to perform a meta-analysis of all systematic reviews, randomized clinical trials and prospective cohort series to quantify the effectiveness of IPDs and to evaluate the potential side-effects...
  73. ncbi Corneal aberrometric and refractive performance of 2 intrastromal corneal ring segment models in early and moderate ectatic disease
    David P Pinero
    Vissum Corporation Instituto Oftalmologico de Alicante, Departamento de Optica, Universidad de Alicante, Alicante, Spain
    J Cataract Refract Surg 36:102-9. 2010
    ..To evaluate and compare visual, refractive, and corneal aberrometric outcomes after implantation of 2 types of intrastromal corneal ring segments (ICRS) in eyes with early to moderate ectatic disease...
  74. ncbi Mechanical biocompatibilities of titanium alloys for biomedical applications
    Mitsuo Niinomi
    Department of Biomaterial Science, Institute for Materials Research, Tohoku University, 2 1 1, Katahira, Aoba ku, Sendai, 980 8577, Japan
    J Mech Behav Biomed Mater 1:30-42. 2008
    ....
  75. ncbi Intrastromal corneal ring segment implantation for the treatment of keratoconus
    Anl Kubaloglu
    Dr Lutfi Kirdar Kartal Training and Research Hospital, 2nd Eye Clinic, Istanbul, Turkey
    Cornea 30:11-7. 2011
    ..To evaluate the safety and efficacy of intrastromal corneal ring segment implantation using both mechanical and femtosecond-assisted tunnel creation for the treatment of patients with keratoconus...
  76. ncbi Intracorneal ring segments for keratoconus correction: long-term follow-up
    Jorge L Alio
    Department of Cornea and Refractive Surgery, Instituto Oftalmologico de Alicante, VISSUM, Spain
    J Cataract Refract Surg 32:978-85. 2006
    ..To evaluate long-term results and stability of intracorneal ring segment (Intacs) implantation for keratoconus correction...
  77. ncbi Intracorneal rings to correct corneal ectasia after laser in situ keratomileusis
    Jorge Alio
    Refractive Surgery and Cornea Unit, Alicante Institute of Ophthalmology, and Miguel Hernández University School of Medicine, Alicante, Spain
    J Cataract Refract Surg 28:1568-74. 2002
    ..To evaluate the potential of using intrastromal corneal ring technology (Intacs, KeraVision) to correct posterior ectasia after laser in situ keratomileusis (LASIK) for myopia...
  78. ncbi Pathogenesis of infections due to coagulase-negative staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Lancet Infect Dis 2:677-85. 2002
    ....
  79. pmc Multiwaveguide implantable probe for light delivery to sets of distributed brain targets
    Anthony N Zorzos
    MIT Media Lab Synthetic Neurobiology Group, Department of Brain and Cognitive Sciences, and MIT McGovern Institute, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Opt Lett 35:4133-5. 2010
    ..1 ± 1 dB/cm using the outscattering method and 3.2 ± 0.4 dB/cm using the cutback method; corner mirror loss, 1.5 ± 0.4 dB); a waveguide coupled, for example, to a 5 mW source will deliver over 1.5 mW to a target at a depth of 1 cm...
  80. ncbi Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants
    R G H Wilke
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, 2052 Australia
    J Neural Eng 8:046016. 2011
    ..However, if the implantation site is further from the target cells, as is the case in suprachoroidal approaches, hexagonally guarded electrode return configurations can convey higher spatial resolution...
  81. ncbi An overview of nano-polymers for orthopedic applications
    Ganesan Balasundaram
    Divisions of Engineering and Orthopaedics, Brown University, Box D, 224 Barus and Holley, 182 Hope Street, Providence, RI 02912, USA
    Macromol Biosci 7:635-42. 2007
    ..Nanotechnology (or the use of nanomaterials) is providing a wide range of new materials to improve the current short lifetimes of orthopedic implants...
  82. pmc Effect of the cord pretension of the Dynesys dynamic stabilisation system on the biomechanics of the lumbar spine: a finite element analysis
    Chien Lin Liu
    Department of Orthopaedic Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur Spine J 20:1850-8. 2011
    ..In addition, use of a 300 N cord pretension causes a much higher stiffness at the implanted level when compared with the intact lumbar spine...
  83. ncbi Clinical features and prognosis of Boston type I keratoprosthesis-associated corneal melt
    Canan Asli Utine
    Ocular Surface Disease and Dry Eye Clinic, Cornea and External Disease Service, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9238, USA
    Ocul Immunol Inflamm 19:413-8. 2011
    ..To describe the clinical features and outcomes of corneal melt associated with Boston type I keratoprosthesis (KPro) implantation...
  84. ncbi Expanding application of the Boston type I keratoprosthesis due to advances in design and improved post-operative therapeutic strategies
    Aisha S Traish
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Semin Ophthalmol 25:239-43. 2010
    ..To evaluate how the advances in design of the Boston type I keratoprosthesis and in the treatment strategies to conquer the post operative complications have expanded the indications and application of this technology...
  85. ncbi Short-term visual outcomes of Boston type 1 keratoprosthesis implantation
    Karen Dunlap
    Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 9238, USA
    Ophthalmology 117:687-92. 2010
    ..To report the short-term visual outcomes after keratoprosthesis implantation...
  86. ncbi In vivo gene expression in response to anodically oxidized versus machined titanium implants
    Omar Omar
    Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Sweden
    J Biomed Mater Res A 92:1552-66. 2010
    ....
  87. ncbi Occult spinous process fractures associated with interspinous process spacers
    David H Kim
    Tufts University School of Medicine, 125 Parker Hill Ave, Boston, MA 02120, USA
    Spine (Phila Pa 1976) 36:E1080-5. 2011
    ..Prospective observational study...
  88. ncbi Enhanced functions of osteoblasts on nanometer diameter carbon fibers
    Kathy L Elias
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
    Biomaterials 23:3279-87. 2002
    ....
  89. ncbi Lumbar interspinous spacers: a systematic review of clinical and biomechanical evidence
    Syed M R Kabir
    National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Spine (Phila Pa 1976) 35:E1499-506. 2010
    ..Systematic review...
  90. ncbi Expanding indications for the Boston keratoprosthesis
    Kathryn A Colby
    Cornea and Refractive Surgery, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 22:267-73. 2011
    ..To review emerging indications for the Boston keratoprosthesis (KPro) and to discuss current research underway to improve clinical outcomes...
  91. ncbi Boston type 1 keratoprosthesis for severe blinding vernal keratoconjunctivitis and Mooren's ulcer
    Sayan Basu
    Cornea and Anterior Segment Service, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills Road No 2, Hyderabad, India
    Int Ophthalmol 31:219-22. 2011
    ..To our knowledge this is the first report of successful Boston keratoprosthesis implantation for these two unusual indications...
  92. doi The role of soft contact lenses as an adjunct to the Boston keratoprosthesis
    Mona Harissi-Dagher
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Int Ophthalmol Clin 48:43-51. 2008
  93. ncbi Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM)
    Jayanthi Parthasarathy
    School of Industrial Engineering, University of Oklahoma, Norman, OK 73019, USA
    J Mech Behav Biomed Mater 3:249-59. 2010
    ....
  94. ncbi The Boston keratoprosthesis in Stevens-Johnson syndrome
    Rony R Sayegh
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 145:438-44. 2008
    ..To evaluate the use of the Boston keratoprosthesis (KPro) in patients with Stevens-Johnson syndrome (SJS)...
  95. ncbi The clinical impact of incomplete left atrial appendage closure with the Watchman Device in patients with atrial fibrillation: a PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients Wit
    Juan F Viles-Gonzalez
    Mount Sinai School of Medicine, New York City, New York, USA
    J Am Coll Cardiol 59:923-9. 2012
    ..Plymouth, Minnesota)...
  96. ncbi Quality of life of lumbar stenosis-treated patients in whom the X STOP interspinous device was implanted
    Ken Y Hsu
    Department of Orthopaedics, St Mary s Medical Center, St Mary s Spine Center, San Francisco, California 94117, USA
    J Neurosurg Spine 5:500-7. 2006
    ....
  97. ncbi One-year results of X Stop interspinous implant for the treatment of lumbar spinal stenosis
    Manal Siddiqui
    Department of Orthopaedics, Woodend Hospital, Aberdeen, Scotland, UK
    Spine (Phila Pa 1976) 32:1345-8. 2007
    ..Prospective observational study...
  98. pmc Two-year results of interspinous spacer (X-Stop) implantation in 175 patients with neurologic intermittent claudication due to lumbar spinal stenosis
    Johannes Kuchta
    Department of Neurosurgery, MediaParc Clinic, Cologne, Germany
    Eur Spine J 18:823-9. 2009
    ..Functional (upright-) MRI examinations were able to demonstrate the positional-dependent stenosis. If available, fMRI represents the most helpful radiologic examination in assessing the outcome of interspinous spacer implantation...
  99. ncbi Cyclic loads do not compromise functionality of the interspinous spacer or cause damage to the spinal segment: an in vitro analysis
    Amanesh Goyal
    Engineering Center for Orthopaedic Research Excellence E CORE, Departments of Bioengineering and Orthopaedic Surgery, Colleges of Engineering and Medicine, University of Toledo, Toledo, Ohio 43606, USA
    J Long Term Eff Med Implants 18:289-302. 2008
    ..A biomechanical study to evaluate the effects of interspinous spacer under cyclic complex loading...
  100. ncbi Aperius PercLID stand alone interspinous system for the treatment of degenerative lumbar stenosis: experience on 152 cases
    Piervittorio Nardi
    Neurosurgical Unit, Policlinico Casilino, Rome, Italy
    J Spinal Disord Tech 23:203-7. 2010
    ..This study is a retrospective clinical investigation of a new interspinous device implanted via a totally percutaneous technique involving 152 consecutive patients...
  101. ncbi Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants
    Bungo Otsuki
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Shogoin, Kyoto 606 8507, Japan
    Biomaterials 27:5892-900. 2006
    ..Data obtained suggest that this sort of novel analysis is useful for evaluating bone and tissue ingrowth into porous biomaterials...

Research Grants71

  1. INDUCTION OF DE NOVO DENTAL PAPILLAE FROM YOUNG RODENT
    Mina Mina; Fiscal Year: 2001
    ..As a result tooth loss is currently being treated by a variety of traditional clinical therapies using prostheses and implants. However, these devices are incapable of replacing all the junctions of the original tooth, often fail ..
  2. Processing of Materials for Improved Biocompatibility
    Michael Matthews; Fiscal Year: 2004
    ..will conduct basic research to improve biocompatibility of materials used in biomedical devices such as prostheses and implants by providing a higher level of cleanliness and decontamination, while simultaneously providing ..
  3. Data Communication with Implantable Micro Devices
    Mingui Sun; Fiscal Year: 2002
    ..We will implant this device within the brain of laboratory dogs and evaluate its performance. ..
  4. FGF-Silyl-Heparin Cerebral Aneurysm Coils
    PAUL ZAMORA; Fiscal Year: 2002
    ..The Phase I studies will develop the coated coils and perform initial animal evaluations. ..
  5. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  6. Motion Sensor Array for Vestibular-deficient Individuals
    Conrad Wall; Fiscal Year: 2005
    ....
  7. PARALLEL INFORMATION PROCESSING OF THE VISUAL SYSTEM
    Peter Schiller; Fiscal Year: 2002
    ..The proposed work has important clinical relevance as it will serve characterize the functions of various visual cortical areas. ..
  8. Thromboresistant vascular grafts:heparin-peptidomimetics
    PAUL ZAMORA; Fiscal Year: 2004
    ..abstract_text> ..
  9. The Role of Areas V1 and V2 in Target Selection
    Peter Schiller; Fiscal Year: 2008
    ..abstract_text> ..
  10. NEURAL CONTROL OF VISUALLY GUIDED EYE MOVEMENTS
    Peter Schiller; Fiscal Year: 2007
    ..abstract_text> ..
  11. Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri
    Stuart Goodman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Infusion of Particles at Implant interfeces
    Stuart Goodman; Fiscal Year: 2006
    ..abstract_text> ..
  13. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  14. Novel vision tests: data analysis from a RP Lutein trial
    Gislin Dagnelie; Fiscal Year: 2004
    ....
  15. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  16. Calibration Tools For PC-Based Vision Enhancement
    Gislin Dagnelie; Fiscal Year: 2008
    ..Project Description Page 7 ..
  17. Bioreactivity Markers in Total Hip Replacments
    Nadim Hallab; Fiscal Year: 2004
    ..Additionally, variable immunologic responses induced by implant degradation products (i.e. lymphocyte response to metal ions and monocyte/macrophage response to particulate debris) will be correlated with the development of osteolysis ..
  18. INJECTABLE SENSORS FOR CONTROL OF FES
    Gerald Loeb; Fiscal Year: 2002
    ....
  19. BION Treatment of Neuromuscular Dysfunction
    Gerald Loeb; Fiscal Year: 2002
    ..abstract_text> ..
  20. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  21. Physiological Role of ADAMTS-7B in Arthritis
    Chuanju Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  22. Coding of action by motor & premotor cortical ensembles
    Nicholas Hatsopoulos; Fiscal Year: 2008
    ..abstract_text> ..
  23. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    JAMES MORLEY ANDERSON; Fiscal Year: 2010
    ..A fibrinogen-based peptide sequence based on fibrinogen/Fbe (S. epidermidis) will be used as a blocking ligand to investigate adhesion blocking mechanisms to prevent bacterial aggregation and biofilm formation. ..
  24. LYMPHOCYTE/MACROPHAGE INTERACTIONS ON BIOMATERIALS
    James Anderson; Fiscal Year: 2001
    ..Results from our combined studies will lead to a greater appreciation of these complex cell/material interactions and novel design criteria for new biomaterials and tissue-engineered surfaces. ..
  25. THE ROLE OF p204 IN OSTEOGENESIS
    Chuanju Liu; Fiscal Year: 2007
    ..A greater understanding of the process of how bone is generated can lead to new therapies which can help stem or reverse the course of these diseases. [unreadable] [unreadable] [unreadable]..
  26. Conference Support: The 13th International Drug Delivery Symposium
    David Grainger; Fiscal Year: 2007
    ..Support is requested both for selected speaker participation costs and 3 junior scientist poster travel awards. [unreadable] [unreadable] [unreadable]..
  27. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin L Kilgore; Fiscal Year: 2010
    ..This research will provide a significant tool in our ongoing efforts to reduce disability and improve quality of life. ..
  28. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    James Anderson; Fiscal Year: 2001
    ..The biomaterial infection model in rats will be used to test the validity of the in vitro models, as well as the efficacy of the biomimetic coatings ..
  29. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..abstract_text> ..
  30. NEUROLOGIC RECOVERY WITH ROBOTIC AIDS
    Neville Hogan; Fiscal Year: 2001
    ..Should the hypotheses be falsified, it is expected that this systematic approach combined with the quality of robot-based measurements will contribute to the scientific foundations of neurologic rehabilitation. ..
  31. Racial Variations in Optic Nerve Head Structure and Biomechanics
    J CRAWFORD contact DOWNS; Fiscal Year: 2011
    ....
  32. 3D Reconstruction of Optic Nerve Heads
    J Downs; Fiscal Year: 2008
    ..Using these 3D reconstructions of the ONH and principles of biomechanical engineering, we can model the mechanical and vascular effects of elevated IOP in glaucoma. [unreadable] [unreadable] [unreadable]..
  33. Reduction and Telemetry of Neural Data for an Implantable Data Acquisition System
    MICHAEL RIZK; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. BioMEMS Model of Glomerular Function
    WILLIAM FISSELL; Fiscal Year: 2008
    ..Third, HP and s will be measured for the NM-PBM membrane. Fourth, data from (1-3) will be compared with existing predictive models of glomerular function. ..
  35. Modeling Sensory Integration and Attention in Postural Control of Older Adults
    Patrick Loughlin; Fiscal Year: 2009
    ..Our research will provide new insights into the interaction of balance and attention through cortical brain imaging while subjects perform balance and attention tasks simultaneously. ..
  36. MORPHOPHYSIOLOGY OF PRE-NUCLEAR OCULOMOTOR NEURONS
    STEPHEN HIGHSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  37. AVS Biomaterials Interface Division Technical Program Support
    David Grainger; Fiscal Year: 2006
    ..A number of relevant leading scientists and engineers from companies working in these technology areas are also recruited to participate using the new "Commercial Challenge" podium opportunity. [unreadable] [unreadable] [unreadable]..
  38. Electrical Stimulation of the Bilaterally Paralyzed Larynx Paced with Respiration
    David L Zealear; Fiscal Year: 2010
    ..This new, more dynamic approach to treatment could restore normal ventilation through the mouth without alteration of voice or swallowing, and return the patient to a physically active lifestyle. ..
  39. Dental Implant Science & Tech Transfer Satellite Meeting
    Jack Lemons; Fiscal Year: 2004
    ..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
  40. BioMEMS Materials for Renal Tissue Engineering
    WILLIAM FISSELL; Fiscal Year: 2004
    ..Failure of RPTCs to grow on these substrates despite a variety of suface modifications would be extremely important, as it would indicate a need for new materials in bioengineering. ..
  41. Novel Biodegradable Polymers for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2004
    ..It is anticipated that at the completion of this project, a viable alternative to existing bone repair materials may be established. ..
  42. A Novel Waveform for Electrical Nerve Conduction Block
    Kevin Kilgore; Fiscal Year: 2002
    ..The initial intended human application will be to alleviate pain in individuals with neuromas secondary to limb amputation. ..
  43. A new allograft that promotes long-term, infection-free skeletal repair
    NOREEN J contact HICKOK; Fiscal Year: 2010
    ....
  44. CRANIOFACIAL DEVELOPMENT: METABOLIC CONTROL OF APOPTOSIS
    Irving Shapiro; Fiscal Year: 2003
    ..Taken together, these studies should highlight the molecular basis of bone cell apoptosis, a phenomenon that is now considered critical for bone growth and skeletal remodeling. ..
  45. EXON-SPECIFIC FIBRONECTIN ISOFORMS AND CHONDROGENESIS
    NOREEN HICKOK; Fiscal Year: 2003
    ..abstract_text> ..
  46. MOTOR RECOVERY AND MOTOR LEARNING IN STROKE PATIENTS
    Neville Hogan; Fiscal Year: 2003
    ..In the case of alternative outcomes it is expected that this systematic approach combined with the quality of robot-based measurements will contribute to a scientific foundation for neurologic rehabilitation. ..
  47. BIOMEDICAL POLYMERS--CELL ADHESION AND CYTOKINES
    James Anderson; Fiscal Year: 2006
    ....
  48. NEW METHOD TO IDENTIFY UNILATERAL VESTIBULAR DYSFUNCTION
    Robert Peterka; Fiscal Year: 2002
    ..Experimental results from subjects with different levels of partial unilateral vestibular loss will determine the effectiveness and reliability of the proposed new rotation test. ..
  49. Knee Implant Wear Evaluation-An Integrated Approach
    Timothy Wright; Fiscal Year: 2005
    ..abstract_text> ..
  50. Analyses of InSitu and Explanted Surgical Implant Devices
    Jack Lemons; Fiscal Year: 2009
    ..abstract_text> ..
  51. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    ..The objective of Phase I is to demonstrate that the device restores normal spine biomechanics (range of motion and stiffness) and is durable in fatigue testing. ..
  52. SURFACE INFLUENCES ON CELL SIGNALING AND PROLIFERATION
    David Grainger; Fiscal Year: 2002
    ....
  53. Engineering FGF-1 for Increased Angiogenicity
    Eric Brey; Fiscal Year: 2005
    ..The two most angiogenic growth factors will then be assessed for their ability to promote angiogenesis and increase blood flow in a diabetic mouse model of critical limb ischemia. ..
  54. Natural History of POP-- A Prospective Cohort Study
    Ingrid Nygaard; Fiscal Year: 2005
    ..The national cost burden is large. This project will provide fundamental data to guide future decisions about intervention threshold, preventative measures, and risk factor modification. ..
  55. TIME VARYING CHARACTERISTICS OF HUMAN POSTURAL SWAY
    Patrick Loughlin; Fiscal Year: 2002
    ..An objective of the research is to improve the evaluation and rehabilitation of individuals with balance disorders. ..
  56. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  57. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2008
    ..valves that improves upon the shortcomings of existing replacement valves, reduces the cost burden on the health care system and improves the survival rate of patients with heart valve prostheses [unreadable] [unreadable] [unreadable]..
  58. GAP JUNCTIONAL COMMUNICATIONS IN WOUND HEALING
    H Ehrlich; Fiscal Year: 2009
    ..abstract_text> ..
  59. Modeling Mass Transfer to Active Implants for Diabetes
    David Gough; Fiscal Year: 2009
    ..This project will examine the permeability of tissues surrounding implanted devices to assess substrate supply to the implant. This information may accelerate implementation of these therapies. ..
  60. Validation of Long-Term Glucose Sensor in Tissues
    David Gough; Fiscal Year: 2007
    ..This project will further validate an implantable glucose sensor that will provide a basis for reliable detection of hypoglycemia and automatic insulin administration. [unreadable] [unreadable] [unreadable]..
  61. An Automated System to Monitor Medical Device Safety
    Frederic Resnic; Fiscal Year: 2009
    ..This approach can be readily extended to monitor the safety of technologies outside of interventional cardiology as outcomes data repositories become available. ..
  62. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  63. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Steven Keteyian; Fiscal Year: 2007
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  64. INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENT
    David Gough; Fiscal Year: 2002
    ..This is necessary to develop biomedical engineering at UCSD to its full potential and to provide a model of bioengineering education and research for the nation. ..
  65. GNE 2007: Global NeuroEngineering 2007
    Miguel Nicolelis; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Corticofugal Modulation of Tactile Sensory Processing
    Miguel Nicolelis; Fiscal Year: 2005
    ..abstract_text> ..
  67. Polymer/Ceramic Composites for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2009
    ..Specific Aim 3: Evaluation of the biological performance of novel 3-D composite matrices using in vivo techniques. ..
  68. REHABILITATION OF THE PARALYZED LARYNX
    David Zealear; Fiscal Year: 2006
    ..With respect to the head and neck, FES could be employed initially to reanimate the unilaterally paralyzed face, larynx and pharynx, and in the process, direct natural reinnervation of these structures. ..
  69. Method for In-Vivo Assessment of Neuronal Dysfunction
    Miguel Nicolelis; Fiscal Year: 2007
    ....
  70. An Ultrasonic Neural Stimulator
    BRUCE TOWE; Fiscal Year: 2002
    ..This market is currently served with conventional electrostimulators by large medical device companies like Medtronic, Guidant, and others. ..