needles

Summary

Summary: Sharp instruments used for puncturing or suturing.

Top Publications

  1. ncbi Validating a new non-penetrating sham acupuncture device: two randomised controlled trials
    Jongbae Park
    Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Acupunct Med 20:168-74. 2002
  2. ncbi Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
  3. ncbi Biomechanical response to acupuncture needling in humans
    H M Langevin
    Department of Neurology, Given C423, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Appl Physiol (1985) 91:2471-8. 2001
  4. ncbi De qi: Chinese acupuncture patients' experiences and beliefs regarding acupuncture needling sensation--an exploratory survey
    Jun J Mao
    Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicne, USA
    Acupunct Med 25:158-65. 2007
  5. ncbi Immunization without needles
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Immunol 5:905-16. 2005
  6. doi Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
  7. pmc Dissolving polymer microneedle patches for influenza vaccination
    Sean P Sullivan
    Wallace H Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    Nat Med 16:915-20. 2010
  8. pmc Microneedle-mediated transdermal bacteriophage delivery
    Elizabeth Ryan
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur J Pharm Sci 47:297-304. 2012
  9. doi EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles
    Uzma D Siddiqui
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Gastrointest Endosc 70:1093-7. 2009
  10. ncbi Detection of icaA and icaD loci by polymerase chain reaction and biofilm formation by Staphylococcus epidermidis isolated from dialysate and needles in a dialysis unit
    K Chaieb
    Laboratoire de Bactériologie de l Hôpital Ibn El Jazzar, rue Ibn Eljazzr, Kairouan 3140, Tunisia
    J Hosp Infect 61:225-30. 2005

Detail Information

Publications279 found, 100 shown here

  1. ncbi Validating a new non-penetrating sham acupuncture device: two randomised controlled trials
    Jongbae Park
    Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Acupunct Med 20:168-74. 2002
    ..test whether the sham procedure using the new device was 1) indistinguishable from the same procedure using real needles in acupuncture naïve subjects, and 2) inactive, where the specific needle sensation (de qi) is taken as a ..
  2. ncbi Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
    ..Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, ..
  3. ncbi Biomechanical response to acupuncture needling in humans
    H M Langevin
    Department of Neurology, Given C423, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Appl Physiol (1985) 91:2471-8. 2001
    During acupuncture treatments, acupuncture needles are manipulated to elicit the characteristic "de qi" reaction widely viewed as essential to acupuncture's therapeutic effect...
  4. ncbi De qi: Chinese acupuncture patients' experiences and beliefs regarding acupuncture needling sensation--an exploratory survey
    Jun J Mao
    Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicne, USA
    Acupunct Med 25:158-65. 2007
    ..The aim of this study was to describe Chinese acupuncture patients' perceived sensations of, and beliefs about, acupuncture needling...
  5. ncbi Immunization without needles
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Immunol 5:905-16. 2005
    Most current immunization procedures make use of needles and syringes for vaccine administration...
  6. doi Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
    De qi is an important traditional acupuncture term used to describe the connection between acupuncture needles and the energy pathways of the body...
  7. pmc Dissolving polymer microneedle patches for influenza vaccination
    Sean P Sullivan
    Wallace H Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    Nat Med 16:915-20. 2010
    ..method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system ..
  8. pmc Microneedle-mediated transdermal bacteriophage delivery
    Elizabeth Ryan
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur J Pharm Sci 47:297-304. 2012
    ..Accordingly, bacteriophage-based therapeutics may now have an alternative route for systemic delivery. Once fully-investigated, this could lead to more widespread investigation of these interesting therapeutic viruses...
  9. doi EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles
    Uzma D Siddiqui
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Gastrointest Endosc 70:1093-7. 2009
    There is a lack of prospective, randomized studies comparing the diagnostic yield and complication rates of 22-gauge and 25-gauge needles during EUS-FNA of solid pancreatic masses.
  10. ncbi Detection of icaA and icaD loci by polymerase chain reaction and biofilm formation by Staphylococcus epidermidis isolated from dialysate and needles in a dialysis unit
    K Chaieb
    Laboratoire de Bactériologie de l Hôpital Ibn El Jazzar, rue Ibn Eljazzr, Kairouan 3140, Tunisia
    J Hosp Infect 61:225-30. 2005
    ..A total of 32 strains of S. epidermidis were identified from dialysates and needles 4h after the initiation of dialysis...
  11. ncbi Does needling sensation (de qi) affect treatment outcome in pain? Analysis of data from a larger single-blind, randomised controlled trial
    Peter White
    School of Health Sciences, University of Southampton, Highfield, Southampton SO171BJ, UK
    Acupunct Med 28:120-5. 2010
    ..Most acupuncturists are taught that obtaining de qi is important when treating patients with pain but this can be quite uncomfortable for patients...
  12. ncbi [Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension]
    Li Wang
    TCM International Cooperation Center of China, Beijing 100101, China
    Zhongguo Zhen Jiu 31:337-41. 2011
    ..To explore the different effects of reinforcing and reducing methods by twirling and rotating the needle on stress-induced hypertension and its mechanism...
  13. ncbi Sonographic identification of needle tip by specialists and novices: a blinded comparison of 5 regional block needles in fresh human cadavers
    Hilary Edgcombe
    Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Reg Anesth Pain Med 35:207-11. 2010
    ..We describe a novel technique for objective assessment of needle-tip identification and present data on a new needle...
  14. doi Acupuncture sensation during ultrasound guided acupuncture needling
    Jongbae J Park
    Department of Physical Medicine and Rehabilitation, UNC Chapel Hill, School of Medicine, 1st Floor, North Wing, UNC Hospitals, Campus Box 7200, Chapel Hill, NC 27599, USA
    Acupunct Med 29:257-65. 2011
    ....
  15. ncbi Polymer microneedles for controlled-release drug delivery
    Jung Hwan Park
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:1008-19. 2006
    ....
  16. doi An experimental study on the self-report of acupuncture needle sensation during deep needling with bi-directional rotation
    Alex Benham
    Faculty of Health, Leeds Metropolitan University, Civic Quarter, Leeds LS1 3HE, UK
    Acupunct Med 28:16-20. 2010
    Traditionally, acupuncturists manipulate needles to enhance sensations referred to as de qi or 'acupuncture needle sensation'. Acupuncture needle sensations are complex and quantifying the experience has been difficult...
  17. pmc The cost-effectiveness of policies for the safe and appropriate use of injection in healthcare settings
    Gerald Dziekan
    Department of Blood Safety and Clinical Technology, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 81:277-85. 2003
    ..We modelled the cost-effectiveness of policies for the safe and appropriate use of injections in ten epidemiological subregions of the world in terms of cost per disability-adjusted life year (DALY) averted...
  18. ncbi Acupuncture using laser needles modulates brain function: first evidence from functional transcranial Doppler sonography and functional magnetic resonance imaging
    G Litscher
    Department of Biomedical Engineering and Research in Anesthesia and Critical Care, Medical University of Graz, Auenbruggerplatz 29, 8036, Austria
    Lasers Med Sci 19:6-11. 2004
    Acupuncture using laser needles is a new totally painless stimulation method which has been described for the first time...
  19. doi A microneedle roller for transdermal drug delivery
    Jung Hwan Park
    Department of BioNano Technology and Gachon BioNano Research Institute, Kyungwon University, Seongnam, Republic of Korea
    Eur J Pharm Biopharm 76:282-9. 2010
    ..Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery...
  20. doi Clinical administration of microneedles: skin puncture, pain and sensation
    M I Haq
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Biomed Microdevices 11:35-47. 2009
    Injections using hypodermic needles cause pain, discomfort, localised trauma and apprehension. Additionally, careful use and disposal of needles is required to avoid transmission of blood-borne pathogens...
  21. ncbi Ultrasound visibility of needles used for regional nerve block: an in vitro study
    Ingeborg Schafhalter-Zoppoth
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA 94110, USA
    Reg Anesth Pain Med 29:480-8. 2004
    Ultrasound visibility of regional block needles is a critical component for safety and success of regional anesthetic procedures...
  22. ncbi Does Deqi (needle sensation) exist?
    Hijoon Park
    Department of Acupuncture and Meridianology, Graduate School of East West Medical Science, Kyung Hee University, Seoul, Republic of Korea
    Am J Chin Med 30:45-50. 2002
    ..Further study involving acupuncture experienced subjects or subjects from other cultures need to confirm this finding. Moreover, sham acupuncture should be studied...
  23. pmc Use of injections in healthcare settings worldwide, 2000: literature review and regional estimates
    Yvan J F Hutin
    Department of Blood Safety and Clinical Technology, World Health Organization, Avenue Appia, 20, CH 1211 Geneva, Switzerland
    BMJ 327:1075. 2003
    ..To describe injection practices worldwide in terms of frequency and safety...
  24. ncbi Changes in ultrasonographic echogenicity and visibility of needles with changes in angles of insonation
    Kremer Nichols
    College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 14:1553-7. 2003
    To objectively compare the echogenicity of several types of needles at clinically important angles of insonation.
  25. doi Blinded prospective comparison of the performance of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of the pancreas and peri-pancreatic lesions
    Jeffrey H Lee
    Department of Gastroenterology, Hepatology, and Nutrition, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd Unit 1433, Houston, TX 77030, USA
    Dig Dis Sci 54:2274-81. 2009
    Both 22- and 25-gauge needles are used for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lesions, yet limited data exist on whether either offers an advantage over the other in terms of specimen cellularity and ..
  26. pmc Formulation of microneedles coated with influenza virus-like particle vaccine
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, Georgia 30332, USA
    AAPS PharmSciTech 11:1193-201. 2010
    ..In summary, this study provides detailed analysis to guide formulation of microneedle patches coated with influenza VLP vaccine and demonstrates effective vaccination in vivo using this system...
  27. pmc Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Pharm Res 28:41-57. 2011
    ..The aim of this study was to optimise polymeric composition and assess the performance of microneedle devices that possess different geometries...
  28. pmc Dissolving microneedles for transdermal drug delivery
    Jeong W Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 29:2113-24. 2008
    Microfabrication technology has been adapted to produce micron-scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines...
  29. ncbi Precise microinjection into skin using hollow microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering, Atlanta, Georgia, USA
    J Invest Dermatol 126:1080-7. 2006
    Hollow needles of micron dimensions have previously been fabricated and envisioned for use with transdermal patches or infusion pumps to achieve painless delivery of drugs to the skin for local and systemic effects without the need for ..
  30. pmc Effect of vapor lock on root canal debridement by using a side-vented needle for positive-pressure irrigant delivery
    Franklin R Tay
    Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1129, USA
    J Endod 36:745-50. 2010
    ....
  31. ncbi Feasibility of microneedles for percutaneous absorption of insulin
    Yukako Ito
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan
    Eur J Pharm Sci 29:82-8. 2006
    ..The wound formed by the administration of microneedle was cured at 72 h after administration. Those results suggest the usefulness of a self-dissolving microneedle for the percutaneous delivery of peptide/protein drugs like insulin...
  32. doi Irrigant flow within a prepared root canal using various flow rates: a Computational Fluid Dynamics study
    C Boutsioukis
    Department of Endodontology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int Endod J 42:144-55. 2009
    ..To study using computer simulation the effect of irrigant flow rate on the flow pattern within a prepared root canal, during final irrigation with a syringe and needle...
  33. ncbi Puncture of solid pancreatic tumors guided by endoscopic ultrasonography: a pilot study series comparing Trucut and 19-gauge and 22-gauge aspiration needles
    T Itoi
    Fourth Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Endoscopy 37:362-6. 2005
    ..compare endoscopic ultrasonography-guided Trucut needle biopsy (EUS-TNB) with EUS-guided fine-needle aspiration biopsy (EUS-FNAB) using 19- and 22-gauge needles for biopsy from different sites in patients with solid pancreatic cancers.
  34. ncbi Dynamic recording of irrigating fluid distribution in root canals using thermal image analysis
    Y D Hsieh
    School of Dentistry, National Defense Medical Centre, Taipei, Taiwan
    Int Endod J 40:11-7. 2007
    To investigate the influence of the size and the depth of insertion of irrigating needles, and the diameter of the master apical file on flow distribution during fluid irrigation in root canals.
  35. ncbi [Acupuncture analgesia and the direction, angle and depth of needle insertion]
    Gang Qi Fan
    Department of Brain, Nanjing Hospital of TCM, Nanjing 210001, Jiangsu Province, China
    Zhongguo Zhen Jiu 30:965-8. 2010
    ....
  36. ncbi Can individuals identify if needling was performed with an acupuncture needle or a non-penetrating sham needle?
    Anna Enblom
    Department of Medical and Health Sciences, Division of Nursing Science, Linkoping University, Sweden
    Complement Ther Med 16:288-94. 2008
    ..A control treatment in acupuncture research must be credible, regardless if the needling is performed by one or by several therapists...
  37. doi Microneedle technologies for (trans)dermal drug and vaccine delivery
    Koen van der Maaden
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University, PO Box 2300 RA, Leiden, The Netherlands
    J Control Release 161:645-55. 2012
    ..Finally, we give our view on research and development that is needed to render microneedle-based (trans)dermal drug delivery technologies clinically useful in the near future...
  38. doi Comparison of different needle diameters and flow rates on bone marrow mononuclear stem cell viability: an ex vivo experimental study
    M Tol
    Cytotherapy 10:98-9. 2008
    ..Optimized stem cell delivery systems might help to maintain better stem cell viability. We have investigated whether needle diameters and flow rates through the needles cause any difference in terms of BMDSC viability.
  39. pmc Processing difficulties and instability of carbohydrate microneedle arrays
    Ryan F Donnelly
    Medical Biology Centre, School of Pharmacy, Queen s University Belfast, Belfast, UK
    Drug Dev Ind Pharm 35:1242-54. 2009
    ....
  40. doi Deep-tissue access with confocal fluorescence microendoscopy through hypodermic needles
    Rajesh S Pillai
    Optical Biomedical Engineering Laboratory, School of Electrical, Electronics and Computer Engineering, The University of Western Australia, 35 Stirling Highway, Crawley 6009 WA, Australia
    Opt Express 19:7213-21. 2011
    ....
  41. ncbi Successful removal of migrated acupuncture needles in a patient with cardiac tamponade by means of intraoperative transesophageal echocardiographic assistance
    Jae Hyeong Park
    Division of Cardiology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea
    J Thorac Cardiovasc Surg 130:210-2. 2005
  42. doi Ex vivo assessment of irrigant penetration and renewal during the final irrigation regimen
    F Bronnec
    Department of Endodontics and Restorative Dentistry, School of Dentistry, Paris 7 Denis Diderot University, Paris, France
    Int Endod J 43:663-72. 2010
    ..To assess irrigant penetration in curved canals after shaping procedures ex vivo...
  43. pmc Deqi sensations without cutaneous sensory input: results of an RCT
    Norbert Salih
    Multidisciplinary Pain Center, Department of Anesthesiology, University of Munich, Munich, Germany
    BMC Complement Altern Med 10:81. 2010
    ..Therefore, we aim to further analyze whether the perceptions reported in the two study arms were distinguishable and whether expectancy effects exhibited considerable impact on our results...
  44. doi Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery
    Katarzyna Migalska
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharm Res 28:1919-30. 2011
    ..To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from aqueous blends of 20% w/w poly(methylvinylether maleic anhydride) (PMVE/MA) in vitro and in vivo...
  45. pmc Improved influenza vaccination in the skin using vaccine coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Vaccine 27:6932-8. 2009
    ..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines...
  46. ncbi Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
    Jung Hwan Park
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 104:51-66. 2005
    To overcome the skin's barrier properties that block transdermal delivery of most drugs, arrays of microscopic needles have been microfabricated primarily out of silicon or metal...
  47. pmc Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Drug Deliv 17:187-207. 2010
    ..This review details various types of MNs, fabrication methods and, importantly, investigations of clinical safety of MN...
  48. ncbi Open magnetic resonance imaging using titanium-zirconium needles: improved accuracy for interstitial brachytherapy implants?
    Y Popowski
    Radiation Oncology Division, University Hospital of Geneva, Switzerland
    Int J Radiat Oncol Biol Phys 47:759-65. 2000
    To evaluate the benefit of using an open magnetic resonance (MR) machine and new MR-compatible needles to improve the accuracy of brachytherapy implants in pelvic tumors.
  49. ncbi Coated microneedles for drug delivery to the eye
    Jason Jiang
    Emory Eye Center, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 48:4038-43. 2007
    ..To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner...
  50. pmc Microneedle-based vaccines
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Curr Top Microbiol Immunol 333:369-93. 2009
    ..To address this need, microneedles have been developed as micron-scale needles fabricated using low-cost manufacturing methods that administer vaccine into the skin using a simple device that ..
  51. doi Transdermal delivery of insulin using microneedle rollers in vivo
    Cui Ping Zhou
    Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Int J Pharm 392:127-33. 2010
    ..Creation and resealing of the skin holes that were produced by the needles were observed by Evan's blue (EB) staining and transepidermal water loss (TEWL) measurements...
  52. pmc Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles
    Jae Min Song
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA
    Antiviral Res 88:244-7. 2010
    ..Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization...
  53. doi Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles
    Wei Zhang
    Department of Pharmaceutics, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Pharm 402:205-12. 2010
    ..The biodegradable nanoparticles would sustain drug release in the skin and supply the skin with drug over a prolonged period. This strategy would prove to be useful for topical drug administration...
  54. doi Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults
    Philippe E Laurent
    BD Medical Pharmaceutical Systems, rue Aristide Bergès, Le Pont de Claix, France
    Vaccine 28:5850-6. 2010
    ..In contrast, the epidermal delivery route did not produce an immune response against the rabies vaccine...
  55. doi Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration
    Kwang Ho Yoo
    Department of Dermatology, College of Medicine, Chung Ang University, Seoul, Korea
    Dermatol Surg 36:618-22. 2010
    ..In several clinical trials of PDT in AA, the dermatologists suspected that skin preparations, including mechanical or chemical peeling, might be incomplete for drug penetration...
  56. doi Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss
    Yasmine A Gomaa
    SIPBS, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, Scotland, UK
    Toxicol In Vitro 24:1971-8. 2010
    ..This is explainable by the longest needles compacting the tissue, which then decompresses over subsequent hours...
  57. pmc Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles
    Fu Shi Quan
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Control Release 147:326-32. 2010
    ..Therefore, this study demonstrates that microneedle vaccination in the skin confers more effective protective immunity at a lower dose, thus providing vaccine dose-sparing effects...
  58. ncbi Ultrasound characteristics of needles for regional anesthesia
    Tim Maecken
    Clinic for Anaesthesiology, Intensive Care, Palliative Care and Pain Medicine, BG University Clinics Bergmannsheil, Bochum, Germany
    Reg Anesth Pain Med 32:440-7. 2007
    ..We performed a prospective study on the ultrasonic imaging quality of various commercially available needles. We tested the hypothesis that different nerve block needles would have different ultrasonic appearances...
  59. ncbi Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    ..In addition to being a valuable tool for studies of acupuncture's mechanism of action, this technique may have applications to other types of needling including biopsies...
  60. ncbi Microporation applications for enhancing drug delivery
    Ajay K Banga
    Mercer University, College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, Atlanta, GA 30341, USA
    Expert Opin Drug Deliv 6:343-54. 2009
    ..Bioavailability considerations and the potential use of inexpensive coated microneedles for mass immunizations are also discussed...
  61. ncbi Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
    H M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    FASEB J 15:2275-82. 2001
    ..Such a mechanism may explain local and remote, as well as long-term effects of acupuncture...
  62. doi Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: dependency on needle size and applied formulation
    M M Badran
    Friedrich Schiller University Jena, Department of Pharmaceutical Technology, Lessingstr 8, 07743 Jena, Germany
    Eur J Pharm Sci 36:511-23. 2009
    ..In conclusion, Dermarollers being already commercially available for cosmetic purposes appear also promising for drug delivery purposes particularly those with medium (500 microm) and shorter (150 microm) needle lengths...
  63. ncbi Influence of irrigant needle depth in removing bioluminescent bacteria inoculated into instrumented root canals using real-time imaging in vitro
    C M Sedgley
    Department of Cariology, Restorative Sciences and Endodontics, University of Michigan Dental School, Ann Arbor, MI 48109 1078, USA
    Int Endod J 38:97-104. 2005
    ..To test the hypothesis that the mechanical efficacy of irrigation in reducing bacteria in the root canal is dependent on depth of placement of the irrigation needle...
  64. ncbi Gene expression using an ultrathin needle enabling accurate displacement and low invasiveness
    SungWoong Han
    Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, 3 11 46 Nakoji, Amagasaki, Hyogo 661 0974, Japan
    Biochem Biophys Res Commun 332:633-9. 2005
    ..demonstrated a new cell manipulation technology by using an atomic force microscope (AFM) and ultrathin needles, named nanoneedles...
  65. doi Influence of the delivery systems using a microneedle array on the permeation of a hydrophilic molecule, calcein
    Jae Ho Oh
    Chungnam National University, Daejeon, South Korea
    Eur J Pharm Biopharm 69:1040-5. 2008
    ..was introduced known as microneedles and these could be pierced to effectively deliver drugs using micron-sized needles in a minimally invasive and painless manner...
  66. pmc Transdermal influenza immunization with vaccine-coated microneedle arrays
    Dimitrios G Koutsonanos
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e4773. 2009
    ....
  67. pmc Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin
    Fu Shi Quan
    Department of Microbiology and Immunology, and Yerkes Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7152. 2009
    ..We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy...
  68. doi In vivo assessment of safety of microneedle arrays in human skin
    Suzanne M Bal
    Department of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Eur J Pharm Sci 35:193-202. 2008
    ..This opens the opportunity for dermal and transdermal delivery of drugs and vaccines...
  69. doi Three-dimensional numeric simulation of root canal irrigant flow with different irrigation needles
    Ya Shen
    Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada
    J Endod 36:884-9. 2010
    ..The purpose of this study was to investigate, by using computational fluid dynamics (CFD), the effect of needle tip design on irrigant flow pattern...
  70. doi Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection
    Shuo Han
    California Institute of Technology, Department of Electrical Engineering, Pasadena, California 91125, USA
    J Biomed Opt 13:020505. 2008
    ..g., vitrectomy)...
  71. pmc Suture needles in oral surgery: alterations depending on the type and number of sutures
    Daniel Torres-Lagares
    Facultad de Odontologia, Universidad de Sevilla, Seville, Spain
    Med Oral Patol Oral Cir Bucal 17:e129-34. 2012
    ..Seventy-five TB-15 needles were studied, which were used to suture between zero and three mucosa and/subperiosteal sutures, producing 15 ..
  72. ncbi Declining HIV rates in Uganda: due to cleaner needles, not abstinence or condoms
    Stuart Brody
    Institute of Medical Psychology and Behavioural Neurobiology, University of Tubingen, Germany
    Int J STD AIDS 15:440-1. 2004
    ..Given the lack of evidence for transmission of HIV to healthy persons by penile-vaginal intercourse, the improvement in injection safety is the best candidate for declining HIV and AIDS rates...
  73. ncbi Cost and cost-effectiveness of increasing access to sterile syringes and needles as an HIV prevention intervention in the United States
    D R Holtgrave
    Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 18:S133-8. 1998
    We determined the cost of increasing access of injection drug users (IDUs) to sterile syringes and needles as an HIV prevention intervention in the United States and the cost per HIV infection averted by such a program...
  74. ncbi Ultrasound measurements of the distance between acupuncture needle tip at P6 and the median nerve
    Konrad Streitberger
    Department of Anaesthesiology and Intensive Care B, Medical University of Vienna, Vienna, Austria
    J Altern Complement Med 13:585-91. 2007
    ..Pericard 6 (P6) is one of the most frequently used acupuncture points, especially in preventing nausea and vomiting. At this point, the median nerve is located very superficially...
  75. doi A randomized clinical trial comparing 22G and 25G needles in endoscopic ultrasound-guided fine-needle aspiration of solid lesions
    L Camellini
    Unit of Gastroenterology and Digestive Endoscopy, Santa Maria Nuova Hospital, Reggio Emilia, Italy
    Endoscopy 43:709-15. 2011
    ..The study aimed to investigate whether the 25G needle is superior to the 22G needle when used in endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of solid lesions...
  76. ncbi Patient outcomes in the GHMonitor: the effect of delivery device on compliance and growth
    Paul DesRosiers
    Department of Pediatric Endocrinology, Nemours Children s Clinic, Orlando, 32806, and Department of Pediatric Endocrinology, University of Florida, Gainesville, FL, USA
    Pediatr Endocrinol Rev 2:327-31. 2005
    ..002). In this group of poorly compliant patients, growth rates were significantly lower than in patients who missed fewer doses. Thus in patients where compliance is an issue, use of the NFDS may result in better outcomes...
  77. pmc A randomized controlled study comparing pain experience between a newly designed needle with a thin tip and a standard needle for oocyte aspiration
    M Wikland
    Fertilitetscentrum, Box 5418, SE 402 29 Goteborg, Sweden
    Hum Reprod 26:1377-83. 2011
    ..The objective of this study was to compare the overall pain experience of a newly designed reduced needle (RN) compared with a thicker standard needle (SN)...
  78. ncbi [The efficacy of safety winged steel needles on needlestick injuries]
    Rie Suzuki
    Department of Infection Control and Prevention, The University of Tokyo Hospital
    Kansenshogaku Zasshi 80:39-45. 2006
    Safety winged steel needles were introduced at the University of Tokyo Hospital in January 2001. We studied their effect in needlestick injuries. A total of 952 'needlestick and sharp-object injuries were reported...
  79. doi The effect of needle-insertion depth on the irrigant flow in the root canal: evaluation using an unsteady computational fluid dynamics model
    Christos Boutsioukis
    Department of Endodontology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Endod 36:1664-8. 2010
    ....
  80. ncbi An expanded surgical suture and needle evaluation and selection program by a healthcare resource management group purchasing organization
    Robin R Szarmach
    Consorta, Inc, Rolling Meadows, IL 60008, USA
    J Long Term Eff Med Implants 13:155-70. 2003
    ..to participate in Phase II of this non-experimental observational study of the clinical performance of surgical needles and sutures...
  81. ncbi Mechanism of fluid infusion during microneedle insertion and retraction
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    J Control Release 112:357-61. 2006
    ..Altogether, these results suggest that microneedle insertion to penetrate into the skin followed by microneedle retraction to relieve skin compaction is an effective approach to infuse fluid into the skin in a minimally invasive manner...
  82. ncbi Sugar micro needles as transdermic drug delivery system
    Takaya Miyano
    Department of Micro System Technology, Ritsumeikan University, Noji higashi 1 1 1, Kusatsu, Shiga 525 8577, Japan
    Biomed Microdevices 7:185-8. 2005
    We designed and fabricated an array of sugar micro needles of the length ranging from 150 micro m to 2 mm for transdermic delivery of drugs...
  83. pmc A scalable fabrication process of polymer microneedles
    Sixing Yang
    School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, People s Republic of China
    Int J Nanomedicine 7:1415-22. 2012
    ..instrument for the drying process, during which the patch shrank evenly to form an array of regular and uniform needles without deformation...
  84. doi Neck pain treatment with acupuncture: does the number of needles matter?
    Francesco Ceccherelli
    Department of Pharmacology and Anesthesiology, University of Padova, Padova, Italy
    Clin J Pain 26:807-12. 2010
    Acupuncture has been successfully used in myofascial pain syndromes. However, the number of needles used, that is, the dose of acupuncture stimulation, to obtain the best antinociceptive efficacy is still a matter of debate...
  85. doi Two-layered dissolving microneedles for percutaneous delivery of sumatriptan in rats
    Yukako Ito
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8412, Japan
    Drug Dev Ind Pharm 37:1387-93. 2011
    ..0 ± 0.3%, 97.8 ± 0.2%, 98.8 ± 0.2%, and 100.7 ± 0.1%. These suggest the usefulness of DM as a noninvaisive transdermal delivery system of ST to migraine therapy...
  86. doi Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
    Martin J Garland
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, UK
    J Control Release 159:52-9. 2012
    ..40%) for MN in combination with anodal ITP (p<0.001). As such, drug loaded soluble PMVE/MA MN arrays show promise for the electrically controlled transdermal delivery of biomacromolecules in a simple, one-step approach...
  87. doi Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs
    Alfred J Harvey
    BD Technologies, 21 Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Pharm Res 28:107-16. 2011
    ..The purpose of this research was to examine the pharmacokinetics (PK) of drug uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs compared to standard subcutaneous (SC) administration...
  88. doi Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles
    Changyoon Baek
    Department of Chemical and Biomolecular Engineering, Kyungwon University, Seongnam, Geonggi do, 461 701, Republic of Korea
    J Control Release 154:138-47. 2011
    ..coli penetrated skin pierced with 23- and 26-gauge hypodermic needles, but E...
  89. doi Use of a battery-operated needle driver for intraosseous access by novice users: skill acquisition with cadavers
    Richard M Levitan
    Albert Einstein Medical Center, Department of Emergency Medicine, 5501 Old York Road, Philadelphia, PA 19141, USA
    Ann Emerg Med 54:692-4. 2009
    ..We determine skill acquisition and performance by using a battery-operated, intraosseous needle driver in cadavers...
  90. doi Comparison of 21 and 27 gauge needles for determining sample adequacy in the aspiration biopsy of thyroid nodules
    Mehmet Gumus
    Department of Radiology, Ataturk Training and Research Hospital, Ankara, Turkey
    Diagn Interv Radiol 18:102-5. 2012
    To compare 21 and 27 gauge (G) needles used for fine-needle aspiration (FNA) of thyroid nodules to obtain better specimens for adequacy and cytological diagnosis.
  91. doi Applicability of press needles to a double-blind trial: a randomized, double-blind, placebo-controlled trial
    Shougo Miyazaki
    Department of Health Services, Management and Policy, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin J Pain 25:438-44. 2009
    ..We evaluated the applicability of a new kind of press needle (Pyonex) to a double-blind trial by comparing the press needle with a placebo (lacking the needle element)...
  92. pmc Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin
    Amit Kumar
    University of Texas at Austin, College of Pharmacy, Pharmaceutics Division, USA
    Int J Nanomedicine 6:1253-64. 2011
    ..Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection...
  93. ncbi Microfabricated silicon microneedles for nonviral cutaneous gene delivery
    F Chabri
    Welsh School of Pharmacy, Cardiff University, Cardiff, UK
    Br J Dermatol 150:869-77. 2004
    ..The superficial lipophilic layer of the skin, the stratum corneum, however, constitutes a major obstacle to the cutaneous delivery of charged macromolecules such as DNA...
  94. doi Assessment of viable tumour tissue attached to needle applicators after local ablation of liver tumours
    Nikol Snoeren
    Department of Surgery, Academic Medical Centre, Meibergdreef 9, Amsterdam, The Netherlands
    Dig Surg 26:56-62. 2009
    ..The aim of this study was to assess the incidence of viable tissue adherent to the needle applicators after ablation to gain insight into the possible mechanisms of local recurrence and needle track seeding...
  95. ncbi Evaluation of self-dissolving needles containing low molecular weight heparin (LMWH) in rats
    Yukako Ito
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8414, Japan
    Int J Pharm 349:124-9. 2008
    Feasibility study of self-dissolving needles containing polysaccharide was performed. Low molecular weight heparin (LMWH) was used as a representative polysaccharide...
  96. doi Safer cordocentesis by new 25-gauge needles
    Yuichi Kawakami
    Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Japan
    Fetal Diagn Ther 24:211-7. 2008
    The objective of this study was to establish safer cordocentesis by using newly produced 25-gauge needles rather than the needles currently used.
  97. ncbi Controlled transdermal delivery of model drug compounds by MEMS microneedle array
    Yu Xie
    Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    Nanomedicine 1:184-90. 2005
    ..This will provide a possible way for the transdermal delivery of macromolecular therapeutic agents such as proteins and vaccines...
  98. doi Formation and closure of microchannels in skin following microporation
    Haripriya Kalluri
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, USA
    Pharm Res 28:82-94. 2011
    ..To characterize the microchannels created in hairless rat skin by microneedles and investigate their closure following exposure to different occlusive conditions...
  99. ncbi Resistance forces acting on suture needles
    T B Frick
    University of New South Wales, Prince of Wales Hospital, Orthopaedic Research Laboratories, Renswick, NSW 2031, Australia
    J Biomech 34:1335-40. 2001
    ..05). This study provides a simple model for measuring force-feedback during needle penetration of soft tissues and is a good starting point for future studies of the penetration resistance properties of human tissues...
  100. pmc Vacuum-assisted breast biopsy: a comparison of 11-gauge and 8-gauge needles in benign breast disease
    Markus Hahn
    Clinic for Obstetrics and Gynaecology, University of Tuebingen, Germany
    World J Surg Oncol 6:51. 2008
    ....
  101. ncbi Pain following controlled cutaneous insertion of needles with different diameters
    Lars Arendt-Nielsen
    Department of Health Sciences and Technology, Aalborg University, Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg, Denmark
    Somatosens Mot Res 23:37-43. 2006
    ..g., insulin), venepuncture, and some neurophysiological procedures. The aim of this paper was to study the influence of the outer needle diameter on the pain evoked by controlled needle insertion...

Research Grants78

  1. Acupuncture to Prevent Postoperative Paralytic lleus
    JOSEPH CHIANG; Fiscal Year: 2004
    ..With each treatment session, 10 needles will be placed on points LI-4, Sp-6, St-36, St-25, CV-6, and CV-12, and electro-acupuncture will be applied at ..
  2. Couples-Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan
    Nabila El Bassel; Fiscal Year: 2010
    ..The primary behavioral outcomes are self- reported proportion of injection acts in which needles or syringes are shared in the past 30 days and proportion of condom-protected acts of sexual intercourse in the ..
  3. Long Circulating Low Molecular Weight Heparins Pulmonary
    Fakhrul Ahsan; Fiscal Year: 2006
    ..However, treatment of VTE using these traditional drugs has many limitations, including the requirement of needles in the administration of heparin, unpredictable pharmacological response, frequent monitoring and dosage ..
  4. Epidemiologic Study on Changing HIV Risks Among FSW-IDUs on the Mexico-US Border
    Steffanie Strathdee; Fiscal Year: 2009
    ..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...
  5. Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
    Kathryn Radabaugh Nightingale; Fiscal Year: 2010
    ..This standard does not involve targeting needles to suspicious regions since PCa does not have unique B-mode ultrasound image characteristics that can delineate ..
  6. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2007
    ..required in confocal microscopy, thus enabling imaging with small probes such as laparoscopes, endoscopes, and needles. 3. Investigate OCT imaging in normal animals and models of cancer progression...
  7. Automated Connective Tissue Torque Sensor
    Robert Davis; Fiscal Year: 2007
    ..our previous research and technological transfer programs which 1) showed that rotation of ultra-fine acupuncture needles causes winding of connective tissue measurable as increased needle torque and 2) suggest that needle torque may ..
  8. Visualization and real-time dosimetry for prostate brachytherapy using ultrasound
    Septimiu Salcudean; Fiscal Year: 2007
    ..The seeds are loaded into hollow needles which are then inserted into the prostate through the perineum using a marked insertion template...
  9. Neighborhood Context and Adolescent Psychological and Behavioral Health
    Christopher R Browning; Fiscal Year: 2010
    ..g., needles/syringes on the streets, garbage on the streets;Skogan, 1990;Sampson &Raudenbush, 1999);(3) social ecologies, ..
  10. Neighborhood Context and Adolescent Psychological and Behavioral Health
    Christopher Browning; Fiscal Year: 2009
    ..g., needles/syringes on the streets, garbage on the streets; Skogan, 1990; Sampson & Raudenbush, 1999); (3) social ..
  11. Holographic Sonic Flashlighlt for Guiding Interventional Procedures
    George Stetten; Fiscal Year: 2007
    ..The hand-held device permits insertion of needles directly into a virtual image of the ultrasound scan, which floats beneath the skin showing the underlying ..
  12. Epidemiologic Study on Changing HIV Risks Among FSW-IDUs on the Mexico-US Border
    Steffanie A Strathdee; Fiscal Year: 2010
    ..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...
  13. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2010
    ..The most striking and surprising finding is that EA, through little needles without any other treatment, remarkably reduces stroke-induced brain injury via the regulation of delta-opioid ..
  14. ROLE OF CONNECTIVE TISSUE GEOMETRY IN ACUPUNCTURE
    HELEN BUETTNER; Fiscal Year: 2007
    ..Acupuncture therapy involves manipulation of the subcutaneous tissue with fine needles inserted through the skin at specific points, termed acupuncture points...
  15. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2009
    ..The most striking and surprising finding is that EA, through little needles without any other treatment, remarkably reduces stroke-induced brain injury via the regulation of delta-opioid ..
  16. Epidemiologic Study on Changing HIV Risks Among FSW-IDUs on the Mexico-US Border
    Steffanie Strathdee; Fiscal Year: 2009
    ..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...
  17. HIV Risk Reduction for Women with Incarcerated Partners
    Olga Grinstead; Fiscal Year: 2005
    ..Some are exposed to HIV before incarceration; others are exposed during incarceration from sharing needles or having unprotected sex in prison where condoms and sterile needles are not available...
  18. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 1999
    ..Control patients have no needles penetrating brain. After surgery, blinded evaluations continue for one year...
  19. NEW NEEDLE FOR TWO-NEEDLE HEMODIALYSIS
    ALFREDO ZARATE; Fiscal Year: 2006
    ..Also, difference in time to stop bleeding from venipuncture sites and the size of thrombus inside the needles will be compared...
  20. Blood Exposure and Primary Prevention in the Home Care *
    JANE LIPSCOMP; Fiscal Year: 2007
    DESCRIPTION: Exposure to blood and body fluids, most often through the use of conventional unsafe needles that transmit bloodborne infections to health care workers, continues to be the most life threatening risk facing healthcare ..
  21. Nanocarriers for transcutaneous delivery of vaccines
    John Clements; Fiscal Year: 2007
    ..confer mucosal as well as systemic immunity, 2) increased stability, 3) increased shelf-life, 4) elimination of needles and the need for specially trained healthcare specialists to administer vaccines, and 5) potentially lower costs...
  22. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    ..In a small number of subjects, we found that stimulation using needles was as effective a...
  23. Targeted prostate biopsy using mathematical optimization
    Christos Davatzikos; Fiscal Year: 2007
    ..to reduce the significant number of cases remaining undetected at initial biopsy, mainly by using additional needles, albeit with limited success...
  24. An fMRI study of expectancy on acupuncture treatment outcomes in knee OA
    Ted Kaptchuk; Fiscal Year: 2010
    ..acupuncture suggesting that at least one healing component is mediated by something other than the acupuncture needles. A recent meta-analysis identified patient expectation of pain relief as the most robust predictor of acupuncture ..