needles

Summary

Summary: Sharp instruments used for puncturing or suturing.

Top Publications

  1. ncbi Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
  2. ncbi Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery
    Katarzyna Migalska
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharm Res 28:1919-30. 2011
  3. ncbi Validating a new non-penetrating sham acupuncture device: two randomised controlled trials
    Jongbae Park
    Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Acupunct Med 20:168-74. 2002
  4. ncbi Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
  5. pmc Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Pharm Res 28:41-57. 2011
  6. ncbi Biomechanical response to acupuncture needling in humans
    H M Langevin
    Department of Neurology, Given C423, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Appl Physiol (1985) 91:2471-8. 2001
  7. ncbi Inserting needles into the body: a meta-analysis of brain activity associated with acupuncture needle stimulation
    Younbyoung Chae
    Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Korea
    J Pain 14:215-22. 2013
  8. ncbi Microneedle technologies for (trans)dermal drug and vaccine delivery
    Koen van der Maaden
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University, PO Box 2300 RA, Leiden, The Netherlands
    J Control Release 161:645-55. 2012
  9. ncbi De qi: Chinese acupuncture patients' experiences and beliefs regarding acupuncture needling sensation--an exploratory survey
    Jun J Mao
    Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicne, USA
    Acupunct Med 25:158-65. 2007
  10. ncbi Functional MRI in healthy subjects during acupuncture: different effects of needle rotation in real and false acupoints
    J L Fang
    Department of Radiology, Guang An Men Hospital, China Academy of Traditional Chinese Medicine, Bei Xian Ge 5, 100053 Peking, China
    Neuroradiology 46:359-62. 2004

Detail Information

Publications311 found, 100 shown here

  1. ncbi Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
    ..Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, ..
  2. ncbi Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery
    Katarzyna Migalska
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharm Res 28:1919-30. 2011
    ..To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from aqueous blends of 20% w/w poly(methylvinylether maleic anhydride) (PMVE/MA) in vitro and in vivo...
  3. ncbi Validating a new non-penetrating sham acupuncture device: two randomised controlled trials
    Jongbae Park
    Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter, UK
    Acupunct Med 20:168-74. 2002
    ..test whether the sham procedure using the new device was 1) indistinguishable from the same procedure using real needles in acupuncture naïve subjects, and 2) inactive, where the specific needle sensation (de qi) is taken as a ..
  4. ncbi Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
    De qi is an important traditional acupuncture term used to describe the connection between acupuncture needles and the energy pathways of the body...
  5. pmc Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Pharm Res 28:41-57. 2011
    ..The aim of this study was to optimise polymeric composition and assess the performance of microneedle devices that possess different geometries...
  6. ncbi Biomechanical response to acupuncture needling in humans
    H M Langevin
    Department of Neurology, Given C423, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Appl Physiol (1985) 91:2471-8. 2001
    During acupuncture treatments, acupuncture needles are manipulated to elicit the characteristic "de qi" reaction widely viewed as essential to acupuncture's therapeutic effect...
  7. ncbi Inserting needles into the body: a meta-analysis of brain activity associated with acupuncture needle stimulation
    Younbyoung Chae
    Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Korea
    J Pain 14:215-22. 2013
    Acupuncture is a therapeutic treatment that is defined as the insertion of needles into the body at specific points (ie, acupoints)...
  8. ncbi Microneedle technologies for (trans)dermal drug and vaccine delivery
    Koen van der Maaden
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research LACDR, Leiden University, PO Box 2300 RA, Leiden, The Netherlands
    J Control Release 161:645-55. 2012
    ..Finally, we give our view on research and development that is needed to render microneedle-based (trans)dermal drug delivery technologies clinically useful in the near future...
  9. ncbi De qi: Chinese acupuncture patients' experiences and beliefs regarding acupuncture needling sensation--an exploratory survey
    Jun J Mao
    Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicne, USA
    Acupunct Med 25:158-65. 2007
    ..The aim of this study was to describe Chinese acupuncture patients' perceived sensations of, and beliefs about, acupuncture needling...
  10. ncbi Functional MRI in healthy subjects during acupuncture: different effects of needle rotation in real and false acupoints
    J L Fang
    Department of Radiology, Guang An Men Hospital, China Academy of Traditional Chinese Medicine, Bei Xian Ge 5, 100053 Peking, China
    Neuroradiology 46:359-62. 2004
    ..These specific cerebral activation patterns might explain the therapeutic effects of acupuncture in certain subjects...
  11. pmc Dissolving polymer microneedle patches for influenza vaccination
    Sean P Sullivan
    Wallace H Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    Nat Med 16:915-20. 2010
    ..method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system ..
  12. ncbi Transdermal delivery of insulin using microneedles in vivo
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 21:947-52. 2004
    ..The purpose of this study was to design and fabricate arrays of solid microneedles and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to lower blood glucose level...
  13. ncbi Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin
    Minyoung Kim
    College of BioNano Technology and Gachon BioNano Research Institute, Gachon University, Seongnam si, Gyeonggi do 461 701, Republic of Korea
    Biomaterials 33:668-78. 2012
    ..However, they have limitations related to the difficulty of achieving separation of the needles into the skin...
  14. pmc Processing difficulties and instability of carbohydrate microneedle arrays
    Ryan F Donnelly
    Medical Biology Centre, School of Pharmacy, Queen s University Belfast, Belfast, UK
    Drug Dev Ind Pharm 35:1242-54. 2009
    ....
  15. ncbi Sonographic identification of needle tip by specialists and novices: a blinded comparison of 5 regional block needles in fresh human cadavers
    Hilary Edgcombe
    Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
    Reg Anesth Pain Med 35:207-11. 2010
    ..We describe a novel technique for objective assessment of needle-tip identification and present data on a new needle...
  16. ncbi Does needling sensation (de qi) affect treatment outcome in pain? Analysis of data from a larger single-blind, randomised controlled trial
    Peter White
    School of Health Sciences, University of Southampton, Highfield, Southampton SO171BJ, UK
    Acupunct Med 28:120-5. 2010
    ..Most acupuncturists are taught that obtaining de qi is important when treating patients with pain but this can be quite uncomfortable for patients...
  17. ncbi Detection of icaA and icaD loci by polymerase chain reaction and biofilm formation by Staphylococcus epidermidis isolated from dialysate and needles in a dialysis unit
    K Chaieb
    Laboratoire de Bactériologie de l Hôpital Ibn El Jazzar, rue Ibn Eljazzr, Kairouan 3140, Tunisia
    J Hosp Infect 61:225-30. 2005
    ..A total of 32 strains of S. epidermidis were identified from dialysates and needles 4h after the initiation of dialysis...
  18. pmc Microneedle-mediated transdermal bacteriophage delivery
    Elizabeth Ryan
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Eur J Pharm Sci 47:297-304. 2012
    ..Accordingly, bacteriophage-based therapeutics may now have an alternative route for systemic delivery. Once fully-investigated, this could lead to more widespread investigation of these interesting therapeutic viruses...
  19. pmc Acupuncture sensation during ultrasound guided acupuncture needling
    Jongbae J Park
    Department of Physical Medicine and Rehabilitation, UNC Chapel Hill, School of Medicine, 1st Floor, North Wing, UNC Hospitals, Campus Box 7200, Chapel Hill, NC 27599, USA
    Acupunct Med 29:257-65. 2011
    ....
  20. pmc The cost-effectiveness of policies for the safe and appropriate use of injection in healthcare settings
    Gerald Dziekan
    Department of Blood Safety and Clinical Technology, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 81:277-85. 2003
    ..We modelled the cost-effectiveness of policies for the safe and appropriate use of injections in ten epidemiological subregions of the world in terms of cost per disability-adjusted life year (DALY) averted...
  21. ncbi Acupuncture using laser needles modulates brain function: first evidence from functional transcranial Doppler sonography and functional magnetic resonance imaging
    G Litscher
    Department of Biomedical Engineering and Research in Anesthesia and Critical Care, Medical University of Graz, Auenbruggerplatz 29, 8036, Austria
    Lasers Med Sci 19:6-11. 2004
    Acupuncture using laser needles is a new totally painless stimulation method which has been described for the first time...
  22. ncbi A microneedle roller for transdermal drug delivery
    Jung Hwan Park
    Department of BioNano Technology and Gachon BioNano Research Institute, Kyungwon University, Seongnam, Republic of Korea
    Eur J Pharm Biopharm 76:282-9. 2010
    ..Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery...
  23. ncbi Clinical administration of microneedles: skin puncture, pain and sensation
    M I Haq
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Biomed Microdevices 11:35-47. 2009
    Injections using hypodermic needles cause pain, discomfort, localised trauma and apprehension. Additionally, careful use and disposal of needles is required to avoid transmission of blood-borne pathogens...
  24. ncbi Credibility of a newly designed placebo needle for clinical trials in acupuncture research
    M Fink
    Department of Physical Medicine and Rehabilitation, Hannover Medical School
    Forsch Komplementarmed Klass Naturheilkd 8:368-72. 2001
    ..To test the credibility of a newly designed placebo needle for acupuncture research...
  25. ncbi Polymer microneedles for controlled-release drug delivery
    Jung Hwan Park
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Pharm Res 23:1008-19. 2006
    ....
  26. ncbi Ultrasound visibility of needles used for regional nerve block: an in vitro study
    Ingeborg Schafhalter-Zoppoth
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA 94110, USA
    Reg Anesth Pain Med 29:480-8. 2004
    Ultrasound visibility of regional block needles is a critical component for safety and success of regional anesthetic procedures...
  27. pmc Use of injections in healthcare settings worldwide, 2000: literature review and regional estimates
    Yvan J F Hutin
    Department of Blood Safety and Clinical Technology, World Health Organization, Avenue Appia, 20, CH 1211 Geneva, Switzerland
    BMJ 327:1075. 2003
    ..To describe injection practices worldwide in terms of frequency and safety...
  28. ncbi Can individuals identify if needling was performed with an acupuncture needle or a non-penetrating sham needle?
    Anna Enblom
    Department of Medical and Health Sciences, Division of Nursing Science, Linkoping University, Sweden
    Complement Ther Med 16:288-94. 2008
    ..A control treatment in acupuncture research must be credible, regardless if the needling is performed by one or by several therapists...
  29. ncbi Influence of the delivery systems using a microneedle array on the permeation of a hydrophilic molecule, calcein
    Jae Ho Oh
    Chungnam National University, Daejeon, South Korea
    Eur J Pharm Biopharm 69:1040-5. 2008
    ..was introduced known as microneedles and these could be pierced to effectively deliver drugs using micron-sized needles in a minimally invasive and painless manner...
  30. ncbi Does Deqi (needle sensation) exist?
    Hijoon Park
    Department of Acupuncture and Meridianology, Graduate School of East West Medical Science, Kyung Hee University, Seoul, Republic of Korea
    Am J Chin Med 30:45-50. 2002
    ..Further study involving acupuncture experienced subjects or subjects from other cultures need to confirm this finding. Moreover, sham acupuncture should be studied...
  31. ncbi Changes in ultrasonographic echogenicity and visibility of needles with changes in angles of insonation
    Kremer Nichols
    College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Vasc Interv Radiol 14:1553-7. 2003
    To objectively compare the echogenicity of several types of needles at clinically important angles of insonation.
  32. ncbi Mechanism of fluid infusion during microneedle insertion and retraction
    Wijaya Martanto
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    J Control Release 112:357-61. 2006
    ..Altogether, these results suggest that microneedle insertion to penetrate into the skin followed by microneedle retraction to relieve skin compaction is an effective approach to infuse fluid into the skin in a minimally invasive manner...
  33. ncbi [Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension]
    Li Wang
    TCM International Cooperation Center of China, Beijing 100101, China
    Zhongguo Zhen Jiu 31:337-41. 2011
    ..To explore the different effects of reinforcing and reducing methods by twirling and rotating the needle on stress-induced hypertension and its mechanism...
  34. ncbi Acupuncture needling sensation: the neural correlates of deqi using fMRI
    Aziz U R Asghar
    York Neuroimaging Centre, University of York, Y10 5DG, UK
    Brain Res 1315:111-8. 2010
    ..Our results show the importance of collecting and accounting for needle sensation data in neuroimaging studies of acupuncture...
  35. pmc Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
    Martin J Garland
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, UK
    J Control Release 159:52-9. 2012
    ..40%) for MN in combination with anodal ITP (p<0.001). As such, drug loaded soluble PMVE/MA MN arrays show promise for the electrically controlled transdermal delivery of biomacromolecules in a simple, one-step approach...
  36. ncbi An experimental study on the self-report of acupuncture needle sensation during deep needling with bi-directional rotation
    Alex Benham
    Faculty of Health, Leeds Metropolitan University, Civic Quarter, Leeds LS1 3HE, UK
    Acupunct Med 28:16-20. 2010
    Traditionally, acupuncturists manipulate needles to enhance sensations referred to as de qi or 'acupuncture needle sensation'. Acupuncture needle sensations are complex and quantifying the experience has been difficult...
  37. ncbi A prospective, randomized trial comparing 25-gauge and 22-gauge needles for endoscopic ultrasound-guided fine needle aspiration of pancreatic masses
    Jun Kyu Lee
    Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University, Seoul, Republic of Korea
    Scand J Gastroenterol 48:752-7. 2013
    ..In this randomized trial, the authors tried to compare prospectively 25G and 22G in diagnostic accuracy, manipulability from the operator's viewpoint and procedure-related complications...
  38. pmc Fabrication of polymer microneedles using a two-photon polymerization and micromolding process
    Shaun D Gittard
    Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, North Carolina, USA
    J Diabetes Sci Technol 3:304-11. 2009
    ..In this study polymer microneedles for transdermal delivery were created using a two-photon polymerization (2PP) microfabrication and subsequent polydimethylsiloxane (PDMS) micromolding process...
  39. ncbi Applicability of press needles to a double-blind trial: a randomized, double-blind, placebo-controlled trial
    Shougo Miyazaki
    Department of Health Services, Management and Policy, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin J Pain 25:438-44. 2009
    ..We evaluated the applicability of a new kind of press needle (Pyonex) to a double-blind trial by comparing the press needle with a placebo (lacking the needle element)...
  40. ncbi In vitro characterization of the invasiveness of polymer microneedle against skin
    Young Wook Noh
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305 764, South Korea
    Int J Pharm 397:201-5. 2010
    The micro-sized needles could pierce the skin to deliver drugs effectively in a minimally invasive and painless manner...
  41. ncbi Modulated iontophoretic delivery of small and large molecules through microchannels
    Vijay Kumar
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA
    Int J Pharm 434:106-14. 2012
    ..05). Therefore, iontophoresis can be used to modulate drug delivery across skin microchannels created by microneedles...
  42. ncbi Acupuncture needle sensations associated with De Qi: a classification based on experts' ratings
    Hugh MacPherson
    Foundation for Traditional Chinese Medicine, York, UK
    J Altern Complement Med 12:633-7. 2006
    ..In experimental trials of acupuncture in which the needle sensation is an important variable, a quantitative measure is needed to monitor and control for variability in de qi...
  43. pmc Skin dendritic cell targeting via microneedle arrays laden with antigen-encapsulated poly-D,L-lactide-co-glycolide nanoparticles induces efficient antitumor and antiviral immune responses
    Marija Zaric
    The Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University Belfast, University Road, Belfast BT9 7AE, United Kingdom
    ACS Nano 7:2042-55. 2013
    ..Therefore, the use of biodegradable polymeric nanoparticles for selective targeting of antigen to skin DC subsets through dissolvable MNs provides a promising technology for improved vaccination efficacy, compliance, and coverage...
  44. ncbi Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose
    Kwang Lee
    Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun gu, Seoul 120 749, Republic of Korea
    Biomaterials 32:3134-40. 2011
    ..We anticipate that controlled drawing technique will be suitable to design dissolving microneedles for use in minimally invasive transcutaneous drug delivery to patients...
  45. ncbi Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate: evaluation of transdermal absorption, safety, and pharmacological effects after application in rats
    Hidemasa Katsumi
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8414, Japan
    J Pharm Sci 101:3230-8. 2012
    ..These findings indicate that this alendronate-loaded microneedle array is a promising transdermal formulation for the treatment of osteoporosis...
  46. ncbi The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin
    Shu Liu
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    J Control Release 161:933-41. 2012
    ..Therefore, HA MNs may be an effective and safe method of transdermal insulin delivery in the clinic...
  47. ncbi Recent advances in the administration of vaccines for infectious diseases: microneedles as painless delivery devices for mass vaccination
    Nagendra R Hegde
    Ella Foundation, Genome Valley, Turkapally, Shameerpet Mandal, Hyderabad 500 078, India
    Drug Discov Today 16:1061-8. 2011
    ..Transdermal delivery using microneedles could revolutionize the way prophylactic interventions for infectious diseases are carried out in the future...
  48. ncbi Echogenic regional anaesthesia needles: a comparison study in Thiel cadavers
    Shuo Guo
    Institute for Medical Science and Technology, University of Dundee, Dundee, Scotland, UK
    Ultrasound Med Biol 38:702-7. 2012
    ..Two new echogenic needles (Pajunk and Braun) have been introduced to anesthesiology clinical practice but evaluation has been restricted to ..
  49. ncbi Blinded prospective comparison of the performance of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of the pancreas and peri-pancreatic lesions
    Jeffrey H Lee
    Department of Gastroenterology, Hepatology, and Nutrition, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd Unit 1433, Houston, TX 77030, USA
    Dig Dis Sci 54:2274-81. 2009
    Both 22- and 25-gauge needles are used for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lesions, yet limited data exist on whether either offers an advantage over the other in terms of specimen cellularity and ..
  50. ncbi Precise microinjection into skin using hollow microneedles
    Ping M Wang
    School of Chemical and Biomolecular Engineering, Atlanta, Georgia, USA
    J Invest Dermatol 126:1080-7. 2006
    Hollow needles of micron dimensions have previously been fabricated and envisioned for use with transdermal patches or infusion pumps to achieve painless delivery of drugs to the skin for local and systemic effects without the need for ..
  51. pmc Formulation of microneedles coated with influenza virus-like particle vaccine
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr, Atlanta, Georgia 30332, USA
    AAPS PharmSciTech 11:1193-201. 2010
    ..In summary, this study provides detailed analysis to guide formulation of microneedle patches coated with influenza VLP vaccine and demonstrates effective vaccination in vivo using this system...
  52. pmc Effect of vapor lock on root canal debridement by using a side-vented needle for positive-pressure irrigant delivery
    Franklin R Tay
    Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1129, USA
    J Endod 36:745-50. 2010
    ....
  53. pmc Dissolving microneedles for transdermal drug delivery
    Jeong W Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 29:2113-24. 2008
    Microfabrication technology has been adapted to produce micron-scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines...
  54. ncbi Puncture of solid pancreatic tumors guided by endoscopic ultrasonography: a pilot study series comparing Trucut and 19-gauge and 22-gauge aspiration needles
    T Itoi
    Fourth Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Endoscopy 37:362-6. 2005
    ..compare endoscopic ultrasonography-guided Trucut needle biopsy (EUS-TNB) with EUS-guided fine-needle aspiration biopsy (EUS-FNAB) using 19- and 22-gauge needles for biopsy from different sites in patients with solid pancreatic cancers.
  55. ncbi Irrigant flow within a prepared root canal using various flow rates: a Computational Fluid Dynamics study
    C Boutsioukis
    Department of Endodontology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Int Endod J 42:144-55. 2009
    ..To study using computer simulation the effect of irrigant flow rate on the flow pattern within a prepared root canal, during final irrigation with a syringe and needle...
  56. ncbi Feasibility of microneedles for percutaneous absorption of insulin
    Yukako Ito
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan
    Eur J Pharm Sci 29:82-8. 2006
    ..The wound formed by the administration of microneedle was cured at 72 h after administration. Those results suggest the usefulness of a self-dissolving microneedle for the percutaneous delivery of peptide/protein drugs like insulin...
  57. ncbi [Acupuncture analgesia and the direction, angle and depth of needle insertion]
    Gang Qi Fan
    Department of Brain, Nanjing Hospital of TCM, Nanjing 210001, Jiangsu Province, China
    Zhongguo Zhen Jiu 30:965-8. 2010
    ....
  58. ncbi Successful removal of migrated acupuncture needles in a patient with cardiac tamponade by means of intraoperative transesophageal echocardiographic assistance
    Jae Hyeong Park
    Division of Cardiology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea
    J Thorac Cardiovasc Surg 130:210-2. 2005
  59. ncbi Deep-tissue access with confocal fluorescence microendoscopy through hypodermic needles
    Rajesh S Pillai
    Optical Biomedical Engineering Laboratory, School of Electrical, Electronics and Computer Engineering, The University of Western Australia, 35 Stirling Highway, Crawley 6009 WA, Australia
    Opt Express 19:7213-21. 2011
    ....
  60. ncbi Ex vivo assessment of irrigant penetration and renewal during the final irrigation regimen
    F Bronnec
    Department of Endodontics and Restorative Dentistry, School of Dentistry, Paris 7 Denis Diderot University, Paris, France
    Int Endod J 43:663-72. 2010
    ..To assess irrigant penetration in curved canals after shaping procedures ex vivo...
  61. ncbi Coated microneedles for drug delivery to the eye
    Jason Jiang
    Emory Eye Center, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 48:4038-43. 2007
    ..To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner...
  62. pmc Microneedle-based vaccines
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Curr Top Microbiol Immunol 333:369-93. 2009
    ..To address this need, microneedles have been developed as micron-scale needles fabricated using low-cost manufacturing methods that administer vaccine into the skin using a simple device that ..
  63. ncbi Open magnetic resonance imaging using titanium-zirconium needles: improved accuracy for interstitial brachytherapy implants?
    Y Popowski
    Radiation Oncology Division, University Hospital of Geneva, Switzerland
    Int J Radiat Oncol Biol Phys 47:759-65. 2000
    To evaluate the benefit of using an open magnetic resonance (MR) machine and new MR-compatible needles to improve the accuracy of brachytherapy implants in pelvic tumors.
  64. pmc Improved influenza vaccination in the skin using vaccine coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Vaccine 27:6932-8. 2009
    ..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines...
  65. ncbi Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration
    Kwang Ho Yoo
    Department of Dermatology, College of Medicine, Chung Ang University, Seoul, Korea
    Dermatol Surg 36:618-22. 2010
    ..In several clinical trials of PDT in AA, the dermatologists suspected that skin preparations, including mechanical or chemical peeling, might be incomplete for drug penetration...
  66. pmc Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles
    Fu Shi Quan
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Control Release 147:326-32. 2010
    ..Therefore, this study demonstrates that microneedle vaccination in the skin confers more effective protective immunity at a lower dose, thus providing vaccine dose-sparing effects...
  67. ncbi Transdermal delivery of insulin using microneedle rollers in vivo
    Cui Ping Zhou
    Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Int J Pharm 392:127-33. 2010
    ..Creation and resealing of the skin holes that were produced by the needles were observed by Evan's blue (EB) staining and transepidermal water loss (TEWL) measurements...
  68. ncbi Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults
    Philippe E Laurent
    BD Medical Pharmaceutical Systems, rue Aristide Bergès, Le Pont de Claix, France
    Vaccine 28:5850-6. 2010
    ..In contrast, the epidermal delivery route did not produce an immune response against the rabies vaccine...
  69. pmc Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles
    Jae Min Song
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA
    Antiviral Res 88:244-7. 2010
    ..Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization...
  70. ncbi Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss
    Yasmine A Gomaa
    SIPBS, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, Scotland, UK
    Toxicol In Vitro 24:1971-8. 2010
    ..This is explainable by the longest needles compacting the tissue, which then decompresses over subsequent hours...
  71. ncbi Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles
    Wei Zhang
    Department of Pharmaceutics, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
    Int J Pharm 402:205-12. 2010
    ..The biodegradable nanoparticles would sustain drug release in the skin and supply the skin with drug over a prolonged period. This strategy would prove to be useful for topical drug administration...
  72. ncbi Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution
    Ryan F Donnelly
    School of Pharmacy, Medical Biology Centre, Queen s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK
    J Control Release 147:333-41. 2010
    ..The successful use of OCT in this study could prove to be a key development for polymeric MN research, accelerating their commercial exploitation...
  73. ncbi Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
    Jung Hwan Park
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 104:51-66. 2005
    To overcome the skin's barrier properties that block transdermal delivery of most drugs, arrays of microscopic needles have been microfabricated primarily out of silicon or metal...
  74. ncbi Ultrasound characteristics of needles for regional anesthesia
    Tim Maecken
    Clinic for Anaesthesiology, Intensive Care, Palliative Care and Pain Medicine, BG University Clinics Bergmannsheil, Bochum, Germany
    Reg Anesth Pain Med 32:440-7. 2007
    ..We performed a prospective study on the ultrasonic imaging quality of various commercially available needles. We tested the hypothesis that different nerve block needles would have different ultrasonic appearances...
  75. ncbi Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    ..In addition to being a valuable tool for studies of acupuncture's mechanism of action, this technique may have applications to other types of needling including biopsies...
  76. pmc Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine
    H S Gill
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Gene Ther 17:811-4. 2010
    ..However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery...
  77. ncbi Needle displacement during HDR brachytherapy in the treatment of prostate cancer
    S J Damore
    Department of Radiation Oncology, Long Beach Memorial Medical Center, Long Beach, CA 90806, USA
    Int J Radiat Oncol Biol Phys 46:1205-11. 2000
    ..We used clinical patient data to examine implant displacement between high dose rate (HDR) brachytherapy fractions for prostate cancer to determine its impact on treatment delivery...
  78. ncbi Discrimination of real and sham acupuncture needles using the park sham device: a preliminary study
    Chee Wee Tan
    School of Health Sciences, Queen Margaret University Edinburgh, Edinburgh, United Kingdom
    Arch Phys Med Rehabil 90:2141-5. 2009
    Tan C-W, Christie L, St-Georges V, Telford N. Discrimination of real and sham acupuncture needles using the Park sham device: a preliminary study.
  79. ncbi Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery
    Chun Yan Jin
    Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Biomed Microdevices 11:1195-203. 2009
    ..We then demonstrated the actual delivery of exogenous materials through application on skin via animal experiments, and we found no detectable side effects such as inflammation or allergic reactions at the site of application...
  80. pmc Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, Belfast, BT9 7BL, UK
    Pharm Res 26:2513-22. 2009
    ..In this study we determined, for the first time, the ability of microorganisms to traverse microneedle-induced holes using two different in vitro models...
  81. pmc Micro-scale devices for transdermal drug delivery
    Anubhav Arora
    Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA
    Int J Pharm 364:227-36. 2008
    ..However, macromolecular drug delivery across the skin is primarily accomplished using hypodermic needles, which have several disadvantages including accidental needle-sticks, pain and needle phobia...
  82. ncbi Incidence and characteristics of potential and actual retained foreign object events in surgical patients
    Robert R Cima
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Am Coll Surg 207:80-7. 2008
    ..Incidence of retained foreign objects (RFOs) after operations is unknown, as many can go unrecognized for years. We reviewed the incidence and characteristics of surgical RFO events at a tertiary care institution during 4 years...
  83. ncbi EUS-guided FNA of solid pancreatic masses: a prospective, randomized trial comparing 22-gauge and 25-gauge needles
    Uzma D Siddiqui
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Gastrointest Endosc 70:1093-7. 2009
    There is a lack of prospective, randomized studies comparing the diagnostic yield and complication rates of 22-gauge and 25-gauge needles during EUS-FNA of solid pancreatic masses.
  84. ncbi Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis
    Xue Ming Wu
    Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Control Release 118:189-95. 2007
    ..These results suggest that the combination of iontophoresis with microneedle pretreatment may be a useful means to increase skin permeation of high molecular compounds...
  85. ncbi Microporation applications for enhancing drug delivery
    Ajay K Banga
    Mercer University, College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, Atlanta, GA 30341, USA
    Expert Opin Drug Deliv 6:343-54. 2009
    ..Bioavailability considerations and the potential use of inexpensive coated microneedles for mass immunizations are also discussed...
  86. ncbi Gene expression using an ultrathin needle enabling accurate displacement and low invasiveness
    SungWoong Han
    Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, 3 11 46 Nakoji, Amagasaki, Hyogo 661 0974, Japan
    Biochem Biophys Res Commun 332:633-9. 2005
    ..demonstrated a new cell manipulation technology by using an atomic force microscope (AFM) and ultrathin needles, named nanoneedles...
  87. ncbi Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: dependency on needle size and applied formulation
    M M Badran
    Friedrich Schiller University Jena, Department of Pharmaceutical Technology, Lessingstr 8, 07743 Jena, Germany
    Eur J Pharm Sci 36:511-23. 2009
    ..In conclusion, Dermarollers being already commercially available for cosmetic purposes appear also promising for drug delivery purposes particularly those with medium (500 microm) and shorter (150 microm) needle lengths...
  88. ncbi Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
    H M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    FASEB J 15:2275-82. 2001
    ..Such a mechanism may explain local and remote, as well as long-term effects of acupuncture...
  89. ncbi Influence of irrigant needle depth in removing bioluminescent bacteria inoculated into instrumented root canals using real-time imaging in vitro
    C M Sedgley
    Department of Cariology, Restorative Sciences and Endodontics, University of Michigan Dental School, Ann Arbor, MI 48109 1078, USA
    Int Endod J 38:97-104. 2005
    ..To test the hypothesis that the mechanical efficacy of irrigation in reducing bacteria in the root canal is dependent on depth of placement of the irrigation needle...
  90. pmc Transdermal influenza immunization with vaccine-coated microneedle arrays
    Dimitrios G Koutsonanos
    Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e4773. 2009
    ....
  91. pmc Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin
    Fu Shi Quan
    Department of Microbiology and Immunology, and Yerkes Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7152. 2009
    ..We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy...
  92. ncbi In vivo assessment of safety of microneedle arrays in human skin
    Suzanne M Bal
    Department of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Eur J Pharm Sci 35:193-202. 2008
    ..This opens the opportunity for dermal and transdermal delivery of drugs and vaccines...
  93. ncbi Immunization without needles
    Samir Mitragotri
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    Nat Rev Immunol 5:905-16. 2005
    Most current immunization procedures make use of needles and syringes for vaccine administration...
  94. ncbi Immunizing children who fear and resist needles: is it a problem for nurses?
    Mary Ives
    Chilliwack Health Unit, Chilliwack, British Columbia, Canada
    Nurs Forum 45:29-39. 2010
    ..Despite increasing evidence that immunization procedures can be stressful for children, little is known about what the experience of immunizing frightened and needle-resistant children can be like for nurses...
  95. doi Comparison of different needle diameters and flow rates on bone marrow mononuclear stem cell viability: an ex vivo experimental study
    M Tol
    Cytotherapy 10:98-9. 2008
    ..Optimized stem cell delivery systems might help to maintain better stem cell viability. We have investigated whether needle diameters and flow rates through the needles cause any difference in terms of BMDSC viability.
  96. ncbi Dynamic recording of irrigating fluid distribution in root canals using thermal image analysis
    Y D Hsieh
    School of Dentistry, National Defense Medical Centre, Taipei, Taiwan
    Int Endod J 40:11-7. 2007
    To investigate the influence of the size and the depth of insertion of irrigating needles, and the diameter of the master apical file on flow distribution during fluid irrigation in root canals.
  97. ncbi Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin
    Huabing Chen
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    J Control Release 139:63-72. 2009
    ..This approach offers a new strategy for non-invasive delivery of peptides with large molecular weights using nanovesicles...
  98. ncbi Microneedles: an emerging transdermal drug delivery system
    Shital H Bariya
    Department of Pharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, NIRMA University, Ahmedabad, Gujarat, India
    J Pharm Pharmacol 64:11-29. 2012
    ..Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area...
  99. ncbi Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Pharm Res 27:2213-20. 2010
    ..To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT...
  100. pmc Kinetics of skin resealing after insertion of microneedles in human subjects
    Jyoti Gupta
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Control Release 154:148-55. 2011
    ..Longer microneedles, increased number of needles, and larger cross-sectional area demonstrated slower resealing kinetics indicating that microneedle geometry ..
  101. ncbi Bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study
    Jay M Stewart
    University of California, San Francisco, Department of Ophthalmology, San Francisco, California, USA
    Ocul Immunol Inflamm 19:32-8. 2011
    To determine the incidence of bacterial contamination of needles used for intravitreal injections.

Research Grants65

  1. Acupuncture to Prevent Postoperative Paralytic lleus
    JOSEPH CHIANG; Fiscal Year: 2004
    ..With each treatment session, 10 needles will be placed on points LI-4, Sp-6, St-36, St-25, CV-6, and CV-12, and electro-acupuncture will be applied at ..
  2. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..activation mapping of multiple transmural bipolar electrograms incorporating Purkinje signals taken from 16 pole needles placed in the risk zone of the anterior descending coronary artery allow 3-D maps of VT/VF produced by extra-..
  3. Targeting the oral cavity epithelium for inducing mucosal immunity against HIV
    Harvinder Singh Gill; Fiscal Year: 2012
    ..We will engineer and develop a vaccination approach based on microscopic needles called microneedles (MNs) that can target vaccines in close proximity to the DCs with microprecision...
  4. A New Low Power Low Cost Ozone Sterilizer for Medical Equipment
    Joseph R Stetter; Fiscal Year: 2012
    ..exclusion of others, which may be materials, methods, techniques, instruments, or devices - include: a) plastic needles to replace steel ones to simplify sharps disposal;b) noncorrosive sterilants without the disadvantages of bleach, ..
  5. Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
    Kathryn Radabaugh Nightingale; Fiscal Year: 2013
    ..This standard does not involve targeting needles to suspicious regions since PCa does not have unique B-mode ultrasound image characteristics that can delineate ..
  6. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2013
    ..The most striking and surprising finding is that EA, through little needles without any other treatment, remarkably reduces stroke-induced brain injury via the regulation of delta-opioid ..
  7. POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATION
    Harvinder Singh Gill; Fiscal Year: 2012
    ..child-friendly, safer and functionally superior to the exiting intramuscular route of vaccination using hypodermic needles. The delivery methodology will have broad applicability and will be able to deliver a broad range of vaccines.
  8. Influenza vaccination using a microneedle patch
    Mark R Prausnitz; Fiscal Year: 2013
    ..Microneedles (MN) are micron-scale, solid needles that administer vaccine directly into skin using a simple, painless and minimally invasive approach...
  9. Transdermal Naltrexone for Opiate Addiction and Alcoholism
    Audra L Stinchcomb; Fiscal Year: 2012
    ..Patches do not require swallowing, eliminating oral side effects;nor do they require skin puncture by syringe needles, eliminating pain and patient visits to a physician...
  10. Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions
    Peter Kazanzides; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Minimally-invasive procedures are pervasive in medicine and further, needles and catheters are among the least invasive vehicles for accessing the interior of the human body...
  11. Using adenoviral vectors to express broadly neutralizing anti-gp160 antibodies
    Shan Liu; Fiscal Year: 2013
    ..Of these new infections, 12% are a direct result of intravenous drug use (IDU, sharing of contaminated needles) and 32% are due to IDU-associated behaviors (heterosexual and homosexual contact with an IDU individual)...
  12. "New Needle for Two-Needle Hemodialysis"
    ALFREDO R ZARATE; Fiscal Year: 2011
    ..use the same HD prescription during both HD including length of dialysis, type of dialyzer non-reused, size of needles (15g), heparin, dialysate composition, and blood and dialysate flow rate...
  13. The Role of Alternative Splicing Factor Sfrs10 in Neural Development
    Rahul N Kanadia; Fiscal Year: 2013
    ..1 have now employed a different method which utilized glass needles that leave a negligible imprint on the retina...
  14. Couples-Based HIV/STI Prevention for Injecting Drug Users in Kazakhstan
    Nabila El-Bassel; Fiscal Year: 2012
    ..The primary behavioral outcomes are self- reported proportion of injection acts in which needles or syringes are shared in the past 30 days and proportion of condom-protected acts of sexual intercourse in the ..
  15. Transdermal Cannabinoid Prodrug Treatment for Cannabis Withdrawal and Dependence
    Lynn Webster; Fiscal Year: 2010
    ..require swallowing, eliminating oral side effects and bitter taste concerns;nor do they require skin puncture by needles, eliminating pain and patient visits to a physician...
  16. Multi-lumen steerable needles for transoral access to lung nodules
    Ron Alterovitz; Fiscal Year: 2013
    ..The new system will harness the capabilities of multi-lumen steerable needles to reliably and safely access any nodule in the lung, including in the peripheral zone...
  17. Broncho-adventitial Drug Delivery: Paclitaxel for Bronchial Carcinoma
    KIRK SEWARD; Fiscal Year: 2013
    ..Prior to the techniques developed in this project, drugs were administered to bronchi with swabs or crude biopsy needles. Treatment options for bronchial carcinoma over the past two decades have grown to include chemotherapy, ..
  18. Harmonically detected swept source OCT
    Kristen A Peterson; Fiscal Year: 2011
    ..Potential applications include imaging of vascular tissue including plaque deposits, guidance of biopsy needles to aid in cancer diagnosis, and guidance tools for microsurgery...
  19. Plant-Derived hepatitis B Vaccine from Biomanufacturing System to Clinical Trial
    Robert Britt; Fiscal Year: 2009
    ..chain" requirements,) storage &handling limitations for liquid vaccines along with the need for hypodermic needles that are regularly reused in third world countries resulting in the spread of hepatitis B and even HIV/AIDS from ..
  20. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..The system will eliminate buckling and steering difficultly in thin (27G) spinal needles and electronically sense entry into the sub-arachnoid space...
  21. Development of Enabling Vector/Antigen Expression Technology for an Orally-Delive
    B Kim Lee Sim; Fiscal Year: 2013
    ..1) need for an easy method of mass vaccination;2) shortcomings of the current anthrax vaccine which requires needles and health professionals for administration, requires an extended vaccination schedule (6 doses over 18 months) ..
  22. Analysis of Toxoplasma sexual development in polarized cat intestinal cells
    Laura J Knoll; Fiscal Year: 2013
    ..it will be stable in any environmental conditions (no refrigeration) and it will be an oral inoculation (no needles). We have been highly successful generating the tools necessary to begin sexual development studies of T...
  23. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    ..a combined procedure with acupuncture and electrical current stimulation instead of manual manipulations of the needles. Recent studies in our lab with EA or transcutaneous EA (TEA) have suggested a therapeutic role of EA or TEA for ..
  24. Staying Safe: Training IDUs in Strategies to Avoid HIV and HCV Infection
    Pedro Mateu Gelabert; Fiscal Year: 2010
    ..g. carrying clean needles to shooting galleries)...
  25. An fMRI study of expectancy on acupuncture treatment outcomes in knee OA
    Ted Kaptchuk; Fiscal Year: 2013
    ..acupuncture suggesting that at least one healing component is mediated by something other than the acupuncture needles. A recent meta-analysis identified patient expectation of pain relief as the most robust predictor of acupuncture ..
  26. Hollow Fiber Catheter for Drug Delivery into the Prostate
    JIM STICE; Fiscal Year: 2010
    ..In contrast to conventional injection needles, the hollow fiber delivery catheter is completely porous;therefore the surface area of tissue in contact with ..
  27. MRI-Compatible Fiber-Optically Sensorized Biopsy Needles for Oncological Applicat
    BEHZAD MOSLEHI; Fiscal Year: 2013
    ..During Phase I, sensors multiplexed along optical fibers were embedded into 18 gauge biopsy needles and used to provide real-time visualization of the entire needle bend shape, including the needle tip position...
  28. Development of OCT Imaging Adapter for Interstitial Tissue Imaging
    Ruikang Wang; Fiscal Year: 2013
    ..adoption of a much needed and significant innovation: forward imaging for all procedures involving hollow-bore needles and probes. In medicine, the majority of needle-based procedures are "blind" (performed without image guidance)...
  29. Development of a lyophilized intradermal/intranasal ricin vaccine
    Ellen S Vitetta; Fiscal Year: 2010
    ..at ambient temperatures or 4[unreadable]C;2) an effective intradermal vaccination regimen that does not require needles and should be immunogenic at lower doses;3) an intranasal formulation that will protect the mucosa against ..
  30. Advancing Clinical Diagnostics Through Improved Blood Sample Self-Collection
    Christi Parham; Fiscal Year: 2013
    ..of blood sample collection is by venipuncture, performed by a registered phlebotomist using invasive hypodermic needles in clinical settings...
  31. A Microneedle Array System for Transcutaneous Nerve Mapping
    James Ross; Fiscal Year: 2010
    ..Each electrode within the array will contain low-cost micropat- terned needles, which dramatically decrease electrode impedance by painlessly piercing the topmost layer of skin, allowing for ..
  32. Epidemiologic Study on Changing HIV Risks Among FSW-IDUs on the Mexico-US Border
    Steffanie A Strathdee; Fiscal Year: 2012
    ..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...
  33. Long Circulating Low Molecular Weight Heparins Pulmonary
    Fakhrul Ahsan; Fiscal Year: 2006
    ..However, treatment of VTE using these traditional drugs has many limitations, including the requirement of needles in the administration of heparin, unpredictable pharmacological response, frequent monitoring and dosage ..
  34. Development of a High Efficiency Plasma Sterilizer
    BRIAN BROSDAHL; Fiscal Year: 2007
    ..medical devices, such as surgical instruments, biopsy forceps, cardiac and urinary catheters, implants and needles, is a major issue of responsibility and liability for health care institutions...
  35. Safe Flexible Intracerebral Navigation with Steerable Needles
    Cameron N Riviere; Fiscal Year: 2012
    ..This aim will involve testing in vivo in a porcine model, with comparisons to standard straight-sided biopsy needles, in order to validate the needle geometry, rotation speed, and insertion speed of the probe, to avoid damage to ..
  36. International Feasibility Study of Pharmacy-based HIV Prevention: San Francisco
    Alexander H Kral; Fiscal Year: 2010
    ..Pharmacies are the most common health-related facilities throughout the world. IDUs often obtain sterile needles and syringes from pharmacies, and there have been a number of studies showing that use of pharmacies is ..
  37. HIV without AIDS: A Radically Different Approach to Help the Developing World
    Warner C Greene; Fiscal Year: 2013
    ..epidemic continues to expand, driven chiefly by sexual transmission of the virus and sharing of contaminated needles among intravenous drug users...
  38. Impact of Needlestick Safety & Prevention Act (HR5178) on Hospital Worker Injury
    Elayne Kornblatt Phillips; Fiscal Year: 2010
    ..It is a national resource for documenting changing injury patterns related to the needles and sharps...
  39. Targeted fusion biopsy using anti-[18F]FACBC PET/CT and real-time 3D ultrasound g
    Viraj Master; Fiscal Year: 2013
    ..PET lesion is superimposed over the real-time ultrasound data;and the fused image is then used to direct biopsy needles to tumor targets...
  40. Pilot Test of an Intervention to Change Syringes Used by Injecting Drug Users
    William A Zule; Fiscal Year: 2013
    ..to switch needle and syringe program (NSP) clients in Tajikistan from high dead space to low dead space needles and syringes...
  41. Modular Ultrasonic Beacon System (MUBS) for Ultrasound-guided Interventional Surg
    Jay Mung; Fiscal Year: 2013
    ..is exacerbated by the fact that ultrasound is optimal for imaging soft tissue and not metallic tools such as needles. What this presents is a new barrier for adoption amongst many would-be practitioners: ultrasound guided needle-..
  42. Automated Connective Tissue Torque Sensor
    Robert Davis; Fiscal Year: 2007
    ..our previous research and technological transfer programs which 1) showed that rotation of ultra-fine acupuncture needles causes winding of connective tissue measurable as increased needle torque and 2) suggest that needle torque may ..
  43. CULTURE, PHYSIOLOGY, GENETICS, INFLUENCING TAXANE YIELDS
    RICK KELSEY; Fiscal Year: 1992
    ..In field-sampled trees, diurnal and seasonal variation of six important taxanes will be measured in needles and bark. Mobility of glycosidic taxanes may contribute to the variation...
  44. Visualization and real-time dosimetry for prostate brachytherapy using ultrasound
    Septimiu Salcudean; Fiscal Year: 2007
    ..The seeds are loaded into hollow needles which are then inserted into the prostate through the perineum using a marked insertion template...
  45. Preventing Blood and Body Fluid Exposures during Surgical Procedures.
    Douglas J Myers; Fiscal Year: 2011
    ..January 2007, include NIOSH-recommended evidence-based safety practices: double-gloving, the use of blunt suture needles and "hands-free techniques" for passing surgical instruments during operations...
  46. Hands-On Virtual Reality Technology for Clinical Education and Training
    Mandayam A Srinivasan; Fiscal Year: 2011
    ..customized training system containing a haptic interface that allows the user to insert real instruments, such as needles and catheters while receiving touch feedback...
  47. DISCRIMINATORY ATTITUDES AND KNOWLEDGE ABOUT AIDS
    Robert Blendon; Fiscal Year: 1990
    ..of measures of the likelihood of transmitting the virus by various means (sexual practices, sharing intravenous needles, prenatal exposure, blood transfusions, coughing or sneezing, working with an infected individual or allow a ..
  48. Multi-Suture Delivery Device for Bioabsorbable Fasteners
    CHARLES H ROGERS; Fiscal Year: 2012
    ..The fastener has two tubular legs with barbs which are carried on two metal needles and inserted from above the wound...
  49. EFFECTS OF ORGANOTINS ON HIPPOCAMPAL NEURONAL DEVELOPMEN
    WILLIAM ATCHISON; Fiscal Year: 2000
    ..Simple exertion of tension on brain neurons with force-calibrated glass needles can cause them to begin to develop their characteristic branching pattern, extend their major process, the axon, ..
  50. A Needle Guidance System for Hepatic Tumor Ablation That Fuses Real-Time Ultrasou
    Sharif Razzaque; Fiscal Year: 2013
    ..In the future, it would be adapted to any procedure in which needles, ultrasound and pre-operative scans such as CT or MRI are employed...
  51. HIV Risk Reduction for Women with Incarcerated Partners
    Olga Grinstead; Fiscal Year: 2005
    ..Some are exposed to HIV before incarceration; others are exposed during incarceration from sharing needles or having unprotected sex in prison where condoms and sterile needles are not available...
  52. Development of needle-free, vectorless, RNA-based vaccines for HIV
    DANIEL GARRETT KAVANAGH; Fiscal Year: 2010
    ..If successful this vaccine will prime protective immunity in the absence of viral vectors or recombinant proteins, and without requiring needles or injection for delivery.
  53. Transdermal Delivery of Buprenorphine Prodrugs
    Audra Stinchcomb; Fiscal Year: 2009
    ..swallowing, eliminating oral side effects and bitter opioid taste concerns;nor do they require skin puncture by needles, eliminating pain and patient visits to a physician...
  54. Holographic Sonic Flashlighlt for Guiding Interventional Procedures
    George Stetten; Fiscal Year: 2009
    ..The hand-held device permits insertion of needles directly into a virtual image of the ultrasound scan, which floats beneath the skin showing the underlying ..
  55. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    ..In a small number of subjects, we found that stimulation using needles was as effective a...
  56. ERBIUM YAG LASER DRILL FOR DENTISTRY
    ABID PAGHDIWALA; Fiscal Year: 1990
    ..Many Americans today evade timely dental care out of fear of the mechanical drills and the dental anesthetic needles. A non-mechanical, non-contacting laser drill, without the grinding, whirring noise would be a boon to these ..
  57. Targeted prostate biopsy using mathematical optimization
    Christos Davatzikos; Fiscal Year: 2007
    ..to reduce the significant number of cases remaining undetected at initial biopsy, mainly by using additional needles, albeit with limited success...
  58. JHU-MCAIDS HPTN TRIAL SITE-CHINA
    JAY JACKSON; Fiscal Year: 2006
    ..HIV prevention interventions with an emphasis on biomedical interventions such as detergent for inactivation of needles, nevirapine prophylaxis, and/or microbicides among IDU populations and their sexual partners/infants...
  59. Acupuncture for Shortness of Breath in Cancer Patients
    MARC FEINSTEIN; Fiscal Year: 2002
    ..Treatment consists of a single acupuncture session followed by administration of semi-permanent acupuncture needles ("studs"). Patients will be instructed on applying acupressure to the studs...
  60. ACUPUNCTURE NEEDLING ON CONNECTIVE TISSUE BY ULTRASOUND
    HELENE LANGEVIN; Fiscal Year: 2001
    During acupuncture treatment, acupuncture needles are inserted and manipulated until a characteristic local tissue reaction termed "de qi" is observed...
  61. Blood Exposure and Primary Prevention in the Home Care *
    JANE LIPSCOMP; Fiscal Year: 2007
    DESCRIPTION: Exposure to blood and body fluids, most often through the use of conventional unsafe needles that transmit bloodborne infections to health care workers, continues to be the most life threatening risk facing healthcare ..
  62. NOVEL ULTRASONIC IMAGING OF BRACHYTHERAPY SEEDS
    ERNEST FELEPPA; Fiscal Year: 2000
    ..However, insertion of seed-implanting needles causes hemorrhage, edema, and other tissue changes in the prostate; these changes create clutter that interferes ..
  63. COMPARISON OF THREE LEVELS OF METHADONE INTERVENTION
    Donald Calsyn; Fiscal Year: 1993
    ..drug users and their sexual partners are a population at major risk for HIV/AIDS because they often share unclean needles and engage in unprotected sex. Since AIDS is lethal, immediate intervention is needed to reduce risk behaviors...
  64. HTLV-I INFECTION AND ATL
    Miguel Suarez; Fiscal Year: 1992
    ..HTLV-I is transmitted through sexual contacts, blood transfusion, sharing of contaminated needles and possibly through insect vectors as well...
  65. Novel Device with Hemostatic Injection System to Control Post Biopsy Bleeding
    Philip Wong; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): In nephrology, the use of conventional percutaneous biopsy needles is associated with the risk of post biopsy bleeding...