needles

..Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, ..

..method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system ..

BACKGROUND AND OBJECTIVES: Ultrasound visibility of regional block needles is a critical component for safety and success of regional anesthetic procedures...

Acupuncture using laser needles is a new totally painless stimulation method which has been described for the first time...

..Attributable fractions and the number of syringes and needles required represented the key sources of uncertainty...

..Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery...

Microfabrication technology has been adapted to produce micron-scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines...

Injections using hypodermic needles cause pain, discomfort, localised trauma and apprehension. Additionally, careful use and disposal of needles is required to avoid transmission of blood-borne pathogens...

..To describe injection practices worldwide in terms of frequency and safety...

..or poly-L: -lactide microparticles and then encapsulating drug-loaded microparticles within needles. RESULTS: By measuring failure force over a range of conditions, poly-lactide-co-glycolide microneedles were ..

To overcome the skin's barrier properties that block transdermal delivery of most drugs, arrays of microscopic needles have been microfabricated primarily out of silicon or metal...

..A total of 32 strains of S. epidermidis were identified from dialysates and needles 4h after the initiation of dialysis...

..These findings suggest that vaccination in the skin using a microneedle patch can improve protective immunity, and simplify delivery of influenza and possibly other vaccines...

..To address this need, microneedles have been developed as micron-scale needles fabricated using low-cost manufacturing methods that administer vaccine into the skin using a simple device that ..

..We describe a novel technique for objective assessment of needle-tip identification and present data on a new needle...

..This review details various types of MNs, fabrication methods and, importantly, investigations of clinical safety of MN...

To evaluate the benefit of using an open magnetic resonance (MR) machine and new MR-compatible needles to improve the accuracy of brachytherapy implants in pelvic tumors.

..To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner...

..Bioavailability considerations and the potential use of inexpensive coated microneedles for mass immunizations are also discussed...

..In several clinical trials of PDT in AA, the dermatologists suspected that skin preparations, including mechanical or chemical peeling, might be incomplete for drug penetration...

..In contrast, the epidermal delivery route did not produce an immune response against the rabies vaccine...

..The biodegradable nanoparticles would sustain drug release in the skin and supply the skin with drug over a prolonged period. This strategy would prove to be useful for topical drug administration...

..This is explainable by the longest needles compacting the tissue, which then decompresses over subsequent hours...

..Therefore, this study demonstrates that microneedle vaccination in the skin confers more effective protective immunity at a lower dose, thus providing vaccine dose-sparing effects...

..Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization...

..Creation and resealing of the skin holes that were produced by the needles were observed by Evan's blue (EB) staining and transepidermal water loss (TEWL) measurements...

..In addition to being a valuable tool for studies of acupuncture's mechanism of action, this technique may have applications to other types of needling including biopsies...

....

..We performed a prospective study on the ultrasonic imaging quality of various commercially available needles. We tested the hypothesis that different nerve block needles would have different ultrasonic appearances...

PURPOSE: To objectively compare the echogenicity of several types of needles at clinically important angles of insonation...

..We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy...

..This opens the opportunity for dermal and transdermal delivery of drugs and vaccines...

....

..We evaluated the applicability of a new kind of press needle (Pyonex) to a double-blind trial by comparing the press needle with a placebo (lacking the needle element)...

..coli penetrated skin pierced with 23- and 26-gauge hypodermic needles, but E...

..g. particle diameter and surface charge, on their diffusion through microchannels and to quantify gene expression in vivo...

To compare 21 and 27 gauge (G) needles used for fine-needle aspiration (FNA) of thyroid nodules to obtain better specimens for adequacy and cytological diagnosis.

Hollow needles of micron dimensions have previously been fabricated and envisioned for use with transdermal patches or infusion pumps to achieve painless delivery of drugs to the skin for local and systemic effects without the need for ..

..To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from aqueous blends of 20% w/w poly(methylvinylether maleic anhydride) (PMVE/MA) in vitro and in vivo...

Both 22- and 25-gauge needles are used for endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lesions, yet limited data exist on whether either offers an advantage over the other in terms of specimen cellularity and ..

..We determine skill acquisition and performance by using a battery-operated, intraosseous needle driver in cadavers...

..The purpose of this research was to examine the pharmacokinetics (PK) of drug uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs compared to standard subcutaneous (SC) administration...

..The aim of this study was to assess the incidence of viable tissue adherent to the needle applicators after ablation to gain insight into the possible mechanisms of local recurrence and needle track seeding...

The objective of this study was to establish safer cordocentesis by using newly produced 25-gauge needles rather than the needles currently used.

..Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection...

Feasibility study of self-dissolving needles containing polysaccharide was performed. Low molecular weight heparin (LMWH) was used as a representative polysaccharide...

There is a lack of prospective, randomized studies comparing the diagnostic yield and complication rates of 22-gauge and 25-gauge needles during EUS-FNA of solid pancreatic masses.

..This will provide a possible way for the transdermal delivery of macromolecular therapeutic agents such as proteins and vaccines...

..The aim of this study was to optimise polymeric composition and assess the performance of microneedle devices that possess different geometries...

....

..To characterize the microchannels created in hairless rat skin by microneedles and investigate their closure following exposure to different occlusive conditions...

..05). This study provides a simple model for measuring force-feedback during needle penetration of soft tissues and is a good starting point for future studies of the penetration resistance properties of human tissues...

..this study is to investigate whether prostate rotation due to needle insertion for prostate brachytherapy is predictable and if so, to quantify this rotation, and to see whether locking needles reduce the magnitude of prostate rotation.

..In this study we determined, for the first time, the ability of microorganisms to traverse microneedle-induced holes using two different in vitro models...

..The case is very interesting and unique: there has been no similar case described in medical literature so far...

The efficacy of peribulbar anaesthesia performed with short, medium and long needles, with sub-Tenon's injection as a control, was audited...

..It is proposed that two factors, microneedle length and tip sharpness, have to be improved for systemic drug delivery to be seen in vivo...

..The aim of this study was to compare the use of blunt tapered and "sharp" needles during abdominal wall closure with respect to the incidence of glove perforation and the convenience of needle ..

The dural and arachnoid hole caused by lumbar puncture needles is a determining factor in triggering headaches...

..Subarachnoid catheters (20- or 16-gauge catheters placed via 18- or 14-gauge epidural needles, respectively) were placed in 17 (3%) patients. In 40 (8%) patients, the type of drain was unspecified...

..g., insulin), venepuncture, and some neurophysiological procedures. The aim of this paper was to study the influence of the outer needle diameter on the pain evoked by controlled needle insertion...

..The purpose of this study was to gain insight into the delivery and immunogenicity of N-trimethyl chitosan (TMC) adjuvanted diphtheria toxoid (DT) formulations applied transcutaneously with microneedles...

..Also, compliance is likely to be higher if the procedure is simple and painless. This study was designed to validate painless intradermal delivery via a patch-like microneedle array...

..In the present study, we used an experimental model without needle removal to investigate the incidence of tissue coring using two different needle types...

..There are few published reports addressing the proportion of IDUs who lick their needles prior to injection and no prior studies evaluating the reasons for this practice.

..known as microneedle was introduced and could be used to pierce effectively to deliver drugs using micron-sized needles in a minimally invasive and painless manner...

..Microneedle vaccination in the skin with H5 VLPs represents a promising approach for a self-administered vaccine against viruses with pandemic potential...

..However, skin pretreatment with microneedles is not the only factor affecting drug transport rates. Other factors, including drug formulation and rate of micropore closure, are also important for optimizing delivery by this route...

To compare the rate of glove perforation as a proxy for needlestick injuries between blunt and sharp needles used during cesarean-delivery closure and to survey physician satisfaction with blunt needles.

..puncture headache (PDPH) is a dreaded complication but can be decreased by the use of non-cutting spinal needles to rates less than 1%...

Tan C-W, Christie L, St-Georges V, Telford N. Discrimination of real and sham acupuncture needles using the Park sham device: a preliminary study.

..The purpose of this study was to determine the safety and efficacy of using a novel radiofrequency (RF) powered transseptal needle to perform transseptal puncture (TSP)...

..Our case highlights that children and adolescents should be warned repeatedly about the risks of putting needles between their teeth...

..Overall, the microneedle array proves to be a very versatile delivery technology, allowing easy and reproducible antigen delivery to skin for efficient vaccination without the use of a needle and syringe...

....

..four trials used true acupuncture points which were not indicated for the condition being treated, in 27 trials needles were inserted outside true acupuncture points, five trials used placebo needles and nine trials used pseudo-..

..This paper introduces the procedure and evaluates the efficacy of the intervention for adhesive capsulitis of the shoulder...

The extent to which a fear of needles influences health decisions remains largely unexplored...

..The results revealed changes in microcirculatory parameters of the skin resulting in an increase in blood flow. However, the quality and intensity of the laser light did not induce micromorphological alterations in the skin...

Needlestick injury (NSI) with hollow-bore needles remains a significant risk of bloodborne virus acquisition in health care workers...

..002). In this group of poorly compliant patients, growth rates were significantly lower than in patients who missed fewer doses. Thus in patients where compliance is an issue, use of the NFDS may result in better outcomes...

..Platinum-coated "wet-etch" silicon micro-needles were shown to be of appropriate dimensions to create micro-conduits, approximately 50 microm in diameter, ..

..paper, we present the case of a 35-year-old Caucasian female, instituted for depression, who swallowed two sewing needles. Despite the fact that the patient on presentation was asymptomatic with a normal clinical examination and blood ..

..test whether the sham procedure using the new device was 1) indistinguishable from the same procedure using real needles in acupuncture naïve subjects, and 2) inactive, where the specific needle sensation (de qi) is taken as a ..

..Pneumothorax occurred in 124 (38%) of 324 patients who underwent procedures with 18-gauge needles and in 121 (23%) of 522 patients who underwent procedures with 19-gauge needles (P <.001)...

..Our findings also challenge the notion that a LuxS/AI-2 quorum-sensing system is operative in B. burgdorferi...

..Further study involving acupuncture experienced subjects or subjects from other cultures need to confirm this finding. Moreover, sham acupuncture should be studied...

..This article reports on a five-bevel needle for subcutaneous administration with a prefillable syringe, and the results of a clinical trial to verify and validate the bench measure of sharpness...

During acupuncture treatments, acupuncture needles are manipulated to elicit the characteristic "de qi" reaction widely viewed as essential to acupuncture's therapeutic effect...

..has been developed, based on magnetic field measurements, to localize, in three dimensions, hypodermic and sewing needles lost in the human body...

..59, p < 0.001). The authors believe that with this improved biopsy guidance they will be able to reduce the "false negative" rate of biopsies, especially in the hands of less experienced physicians...

..60) than for the Curasan PRP (r(S) = 0.34). A slight, clinically irrelevant, influence of gender on thrombocyte concentration in whole blood was found, but no influence of age was detected...

..The purpose of this study was to assess children's reaction while receiving dental local anaesthesia with a 27- and a 30-gauge needle and to record their sensation...

..We present a new retraction technique for the intraoral injection of a local anesthetic. This approach eliminates the hazards associated with needle-stick injuries during the injection procedure...

..A historic injection complication classification system is presented along with a management strategy based upon a review of reported provider experiences and treatment suggestions...

..Pressure applied to an ultrasound transducer can occlude venous structures making negative aspiration of blood unreliable for excluding intravascular needle placement...

..To identify and integrate new safety technologies into outpatient musculoskeletal procedures and measure the effect on outcome, including pain...

New 27-gauge side-perforated needles were compared with conventional needles during injection in dense tissues on the basis of (a) the force to be applied on the syringe plunger and (b) the frequency of complete needle clogging...

..The author reviews historical methods and the instruments used to bring about intraosseous anesthesia, or IOA; discusses the criteria for successful use of the intraosseous injection, or IOI, technique; and provides recommendations...

..With each treatment session, 10 needles will be placed on points LI-4, Sp-6, St-36, St-25, CV-6, and CV-12, and electro-acupuncture will be applied at ..

..The primary behavioral outcomes are self- reported proportion of injection acts in which needles or syringes are shared in the past 30 days and proportion of condom-protected acts of sexual intercourse in the ..

..However, treatment of VTE using these traditional drugs has many limitations, including the requirement of needles in the administration of heparin, unpredictable pharmacological response, frequent monitoring and dosage ..

..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...

..This standard does not involve targeting needles to suspicious regions since PCa does not have unique B-mode ultrasound image characteristics that can delineate ..

..required in confocal microscopy, thus enabling imaging with small probes such as laparoscopes, endoscopes, and needles. 3. Investigate OCT imaging in normal animals and models of cancer progression...

..our previous research and technological transfer programs which 1) showed that rotation of ultra-fine acupuncture needles causes winding of connective tissue measurable as increased needle torque and 2) suggest that needle torque may ..

..The seeds are loaded into hollow needles which are then inserted into the prostate through the perineum using a marked insertion template...

..g., needles/syringes on the streets, garbage on the streets;Skogan, 1990;Sampson &Raudenbush, 1999);(3) social ecologies, ..

..g., needles/syringes on the streets, garbage on the streets; Skogan, 1990; Sampson & Raudenbush, 1999); (3) social ..

..The hand-held device permits insertion of needles directly into a virtual image of the ultrasound scan, which floats beneath the skin showing the underlying ..

..Acupuncture therapy involves manipulation of the subcutaneous tissue with fine needles inserted through the skin at specific points, termed acupuncture points...

..The most striking and surprising finding is that EA, through little needles without any other treatment, remarkably reduces stroke-induced brain injury via the regulation of delta-opioid ..

..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...

..The most striking and surprising finding is that EA, through little needles without any other treatment, remarkably reduces stroke-induced brain injury via the regulation of delta-opioid ..

..To evaluate the joint effects of these two behavioral interventions to increase condom use and reduce sharing of needles/injection paraphernalia among FSW- IDUs...

..Some are exposed to HIV before incarceration; others are exposed during incarceration from sharing needles or having unprotected sex in prison where condoms and sterile needles are not available...

..Also, difference in time to stop bleeding from venipuncture sites and the size of thrombus inside the needles will be compared...

..Control patients have no needles penetrating brain. After surgery, blinded evaluations continue for one year...

..confer mucosal as well as systemic immunity, 2) increased stability, 3) increased shelf-life, 4) elimination of needles and the need for specially trained healthcare specialists to administer vaccines, and 5) potentially lower costs...

DESCRIPTION: Exposure to blood and body fluids, most often through the use of conventional unsafe needles that transmit bloodborne infections to health care workers, continues to be the most life threatening risk facing healthcare ..

..In a small number of subjects, we found that stimulation using needles was as effective a...

..to reduce the significant number of cases remaining undetected at initial biopsy, mainly by using additional needles, albeit with limited success...

..acupuncture suggesting that at least one healing component is mediated by something other than the acupuncture needles. A recent meta-analysis identified patient expectation of pain relief as the most robust predictor of acupuncture ..