lenses

Summary

Summary: Pieces of glass or other transparent materials used for magnification or increased visual acuity.

Top Publications

  1. ncbi On wave-breaking free fiber lasers mode-locked with two saturable absorber mechanisms
    Axel Ruehl
    Laser Zentrum Hannover e V, Hollerithallee 8, 30419 Hannover, Germany
    Opt Express 16:8181-9. 2008
  2. ncbi Wheel-chair driving improvement following visuo-manual prism adaptation
    Sophie Jacquin-Courtois
    Espace et Action, UMR S 534, INSERM UCBL, Bron, France
    Cortex 44:90-6. 2008
  3. ncbi Analyzer-based x-ray phase-contrast microscopy combining channel-cut and asymmetrically cut crystals
    M G Hönnicke
    LORXI, Departamento de Fisica, Universidade Federal do Parana, Caixa Postal 19091, 81531 990 Curitiba, Parana, Brazil
    Rev Sci Instrum 78:113708. 2007
  4. ncbi Magnifying lenses assisted nerve-sparing radical hysterectomy and prevention of nerve plexus trauma
    G Mantzaris
    1st Department of Obstetrics and Gynecology, Gynecologic Oncology Unit and Urogynecology Unit, University of Athens, Alexandra Hospital, Athens, Greece
    Int J Gynecol Cancer 18:868-75. 2008
  5. ncbi Three-dimensional nonlinear optical endoscopy
    Ling Fu
    J Biomed Opt 12:040501. 2007
  6. pmc Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy
    Alon Greenbaum
    Electrical Engineering Department, University of California, Los Angeles, Los Angeles, California, USA
    Nat Methods 9:889-95. 2012
  7. ncbi Aberration-free ultrathin flat lenses and axicons at telecom wavelengths based on plasmonic metasurfaces
    Francesco Aieta
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States
    Nano Lett 12:4932-6. 2012
  8. pmc Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications
    Onur Mudanyali
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1417-28. 2010
  9. ncbi Field-portable wide-field microscopy of dense samples using multi-height pixel super-resolution based lensfree imaging
    Alon Greenbaum
    UCLA Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 12:1242-5. 2012
  10. pmc Lensfree on-chip microscopy over a wide field-of-view using pixel super-resolution
    Waheb Bishara
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Opt Express 18:11181-91. 2010

Detail Information

Publications246 found, 100 shown here

  1. ncbi On wave-breaking free fiber lasers mode-locked with two saturable absorber mechanisms
    Axel Ruehl
    Laser Zentrum Hannover e V, Hollerithallee 8, 30419 Hannover, Germany
    Opt Express 16:8181-9. 2008
    ..The impact of the modulation depth and the non-saturated losses is discussed via comparative measurements with different saturable Bragg reflectors...
  2. ncbi Wheel-chair driving improvement following visuo-manual prism adaptation
    Sophie Jacquin-Courtois
    Espace et Action, UMR S 534, INSERM UCBL, Bron, France
    Cortex 44:90-6. 2008
    ..The potential implications of prism adaptation for the rehabilitation of unilateral neglect are highlighted by the long duration of improvement obtained after a single adaptation session...
  3. ncbi Analyzer-based x-ray phase-contrast microscopy combining channel-cut and asymmetrically cut crystals
    M G Hönnicke
    LORXI, Departamento de Fisica, Universidade Federal do Parana, Caixa Postal 19091, 81531 990 Curitiba, Parana, Brazil
    Rev Sci Instrum 78:113708. 2007
    ..Moreover, thanks to the combination with the nondispersive ABI setup, the diffraction-enhanced x-ray imaging algorithm could be applied...
  4. ncbi Magnifying lenses assisted nerve-sparing radical hysterectomy and prevention of nerve plexus trauma
    G Mantzaris
    1st Department of Obstetrics and Gynecology, Gynecologic Oncology Unit and Urogynecology Unit, University of Athens, Alexandra Hospital, Athens, Greece
    Int J Gynecol Cancer 18:868-75. 2008
    ..were to present a new approach for nerve-sparing radical hysterectomy (NSRH) with the assistance of magnifying lenses and to describe the differences in autonomic nerve plexus trauma between NSRH type III and conventional radical ..
  5. ncbi Three-dimensional nonlinear optical endoscopy
    Ling Fu
    J Biomed Opt 12:040501. 2007
    ....
  6. pmc Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy
    Alon Greenbaum
    Electrical Engineering Department, University of California, Los Angeles, Los Angeles, California, USA
    Nat Methods 9:889-95. 2012
    ..5 gigapixels. We also discuss the current challenges that these computational on-chip microscopes face, shedding light on their future directions and applications...
  7. ncbi Aberration-free ultrathin flat lenses and axicons at telecom wavelengths based on plasmonic metasurfaces
    Francesco Aieta
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States
    Nano Lett 12:4932-6. 2012
    The concept of optical phase discontinuities is applied to the design and demonstration of aberration-free planar lenses and axicons, comprising a phased array of ultrathin subwavelength-spaced optical antennas...
  8. pmc Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications
    Onur Mudanyali
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1417-28. 2010
    ..This compact and light-weight microscope is based on digital in-line holography and does not need any lenses, bulky optical/mechanical components or coherent sources such as lasers...
  9. ncbi Field-portable wide-field microscopy of dense samples using multi-height pixel super-resolution based lensfree imaging
    Alon Greenbaum
    UCLA Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 12:1242-5. 2012
    ..Our results reveal the promising potential of this multi-height lensfree computational microscopy platform for e.g., pathology needs in resource limited settings...
  10. pmc Lensfree on-chip microscopy over a wide field-of-view using pixel super-resolution
    Waheb Bishara
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Opt Express 18:11181-91. 2010
    ..We demonstrate the success of this pixel super-resolution approach by imaging patterned transparent substrates, blood smear samples, as well as Caenoharbditis Elegans...
  11. ncbi Plasmonic Luneburg and Eaton lenses
    Thomas Zentgraf
    NSF Nanoscale Science and Engineering Center, 3112 Etcheverry Hall, University of California, Berkeley, California 94720, USA
    Nat Nanotechnol 6:151-5. 2011
    ..Plasmonics-based optical elements such as waveguides, lenses, beamsplitters and reflectors have been implemented by structuring metal surfaces or placing dielectric structures ..
  12. ncbi Two dimensional hard x-ray nanofocusing with crossed multilayer Laue lenses
    Hanfei Yan
    Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Opt Express 19:15069-76. 2011
    ..Here we report two-dimensional nanofocusing by multilayer Laue lenses (MLLs), a type of diffractive optics that is in principle capable of focusing x-rays to 1 nm...
  13. ncbi Refractive elements for the measurement of the orbital angular momentum of a single photon
    Martin P J Lavery
    School of Physics and Astronomy, University of Glasgow, Glasgow, G12 8QQ, UK
    Opt Express 20:2110-5. 2012
    ....
  14. ncbi Polarization splitter and polarization rotator designs based on transformation optics
    Do Hoon Kwon
    Department of Electrical and Computer Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Opt Express 16:18731-8. 2008
    ..The polarization rotator rotates the polarization state of an incoming beam by an arbitrary angle. Both optical devices are reflectionless at the entry and exit interfaces. Design details and full-wave simulation results are provided...
  15. ncbi Posterior parietal cortex and the dissociable components of prism adaptation
    R Newport
    School of Psychology, University of Nottingham, Nottingham NG7 2RD, UK
    Neuropsychologia 44:2757-65. 2006
    ..The data indicates that the ability to implement control strategies may not be necessary for successful adaptation to prisms. A proposed model for the role of posterior parietal cortex in prism adaptation is also presented...
  16. ncbi Wavelength-scale lens microscopy via thermal reshaping of colloidal particles
    Alexandru Vlad
    Institute of Information, Communication Technologies, Electronics and Applied Mathematics, Electrical Engineering, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Nanotechnology 23:285708. 2012
    b>Lenses are by far the most simple tools for visualization...
  17. ncbi Plasmonic lenses formed by two-dimensional nanometric cross-shaped aperture arrays for Fresnel-region focusing
    Ling Lin
    School of Physics, The University of Melbourne, Vic, Australia
    Nano Lett 10:1936-40. 2010
    We present the experimental demonstration of what are to our knowledge the first two-dimensional planar plasmonic lenses formed by an array of spatially varying cross-shaped apertures in a metallic film for Fresnel-region focusing...
  18. pmc Compact and light-weight automated semen analysis platform using lensfree on-chip microscopy
    Ting wei Su
    Electrical Engineering Department, University of California, Los Angeles, California, USA
    Anal Chem 82:8307-12. 2010
    ..2 × 4.2 × 5.8 cm, and does not require any lenses, lasers or other bulky optical components to achieve phase and amplitude imaging of sperms over ∼24 mm(2) field-..
  19. ncbi Synthesis and dynamic switching of surface plasmon vortices with plasmonic vortex lens
    Hwi Kim
    National Creative Research Center for Active Plasmonics Application Systems, Inter University Semiconductor Research Center and School of Electrical Engineering, Seoul National University, Gwanak Gu Gwanakro 599, Seoul 151 744, Korea
    Nano Lett 10:529-36. 2010
    ..The synthesis and dynamic switching of higher order surface plasmon vortices have profound potential in optical trapping, optical data storage, and other related fields...
  20. ncbi Mechanisms underlying neglect recovery after prism adaptation
    Andrea Serino
    Dipartimento di Psicologia, Universita di Bologna, Italy
    Neuropsychologia 44:1068-78. 2006
    ....
  21. ncbi Long-lasting amelioration of visuospatial neglect by prism adaptation
    Francesca Frassinetti
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Bologna, Italy
    Brain 125:608-23. 2002
    ..Seven patients with right hemisphere lesion and left visuospatial neglect were treated with prismatic lenses in twice-daily sessions over a period of 2 weeks...
  22. pmc Lensfree microscopy on a cellphone
    Derek Tseng
    UCLA Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1787-92. 2010
    ..This compact and light-weight holographic microscope installed on a cellphone does not utilize any lenses, lasers or other bulky optical components and it may offer a cost-effective tool for telemedicine applications to ..
  23. ncbi Influence of loupes and age on the near visual acuity of practicing dentists
    Martina Eichenberger
    University of Bern, School of Dental Medicine, Department of Preventive, Restorative and Pediatric Dentistry, Bern, Switzerland
    J Biomed Opt 16:035003. 2011
    ..01). It can be concluded that near visual acuity varies highly between individuals and decreases during the lifetime. Independent of age or natural vision, visual acuity can be significantly improved by using magnification devices...
  24. ncbi Microfluidic droplet grating for reconfigurable optical diffraction
    J Q Yu
    1School of Electrical and Electronic Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore
    Opt Lett 35:1890-2. 2010
    ..Such a grating has the advantages of high stability and wide tunability in droplet size, grating period, and refractive index, making it promising for biochemical and biomaterial applications...
  25. ncbi Selective modulation of scleral proteoglycan mRNA levels during minus lens compensation and recovery
    John Thomas Siegwart
    Department of Vision Sciences, School of Optometry, The University of Alabama at Birmingham, Birmingham, AL, USA
    Mol Vis 13:1878-86. 2007
    ..To better characterize the role of proteoglycans in scleral tissue remodeling during the development of minus lens induced myopia and during recovery in tree shrews...
  26. ncbi Eye movements tell only half the story
    S Ferber
    CIHR Group on Action and Perception, Department of Psychology, University of Western Ontario, London, Canada
    Neurology 60:1826-9. 2003
    ..PA modulates functions of the parietal lobe, such as eye movement control, but fails to influence the underlying mechanisms of neglect...
  27. ncbi Near-field focusing of the dielectric microsphere with wavelength scale radius
    Hanming Guo
    Engineering Research Center of Optical Instrument and System, Ministry of Education, Shanghai Key Lab of Modern Optical System, School of Optical Electrical and Computer Engineering, University of Shanghai for Science and Technology, 516 Jungong Rd, Shanghai 200093, China
    Opt Express 21:2434-43. 2013
    ....
  28. ncbi Tunable lenses using transparent dielectric elastomer actuators
    Samuel Shian
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
    Opt Express 21:8669-76. 2013
    Focus tunable, adaptive lenses provide several advantages over traditional lens assemblies in terms of compactness, cost, efficiency, and flexibility...
  29. ncbi Experimental far-field imaging properties of a ~5-μm diameter spherical lens
    Ran Ye
    Department of Physics, Nanjing Normal University, Nanjing 210097, China
    Opt Lett 38:1829-31. 2013
    Microscale lenses are mostly used as near-sighted lenses. The far-field imaging properties of a microscale spherical lens, where the lens is spatially separated from the object, are experimentally studied...
  30. pmc Near-field examination of perovskite-based superlenses and superlens-enhanced probe-object coupling
    S C Kehr
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Commun 2:249. 2011
    ..Comparisons with numerical simulations indicate that this maximum originates from an enhanced coupling between probe and object, which might be applicable for multifunctional circuits, infrared spectroscopy and thermal sensors...
  31. ncbi Evaluation of a district-wide screening programme for diabetic retinopathy utilizing trained optometrists using slit-lamp and Volk lenses
    S A Hulme
    Diabetes Centre, Whiston Hospital, Prescot and Rennie Eye Clinic, St Helens Hospital, St Helens, UK
    Diabet Med 19:741-5. 2002
    ..Optometrists offer flexibility but sensitivity and specificity of schemes have varied considerably, perhaps because of variability in screening methodology and that there is frequently no quality assurance programme...
  32. ncbi Optical ptychography: a practical implementation with useful resolution
    Andrew M Maiden
    Department of Electrical and Electronic Engineering, University of Sheffield, Sheffield S1 3JD, UK
    Opt Lett 35:2585-7. 2010
    ..The microscope uses the recently reported coherent diffractive imaging technique of ptychography to generate images from recorded diffraction patterns...
  33. ncbi Magnification in a restorative dental practice: from loupes to microscopes
    Mark J Friedman
    Center for Dental Aesthetics, Encino, California, USA
    Compend Contin Educ Dent 25:48, 50, 53-5. 2004
    ..Using the appropriate visual enhancement should be considered for all dental professionals to make the practice of dentistry more precise, easier, and more enjoyable and to reduce the risk of musculoskeletal injury...
  34. ncbi Tunable Liquid Gradient Refractive Index (L-GRIN) lens with two degrees of freedom
    Xiaole Mao
    Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA
    Lab Chip 9:2050-8. 2009
    ..This work provides a new strategy for developing integrative tunable microlenses for a variety of lab-on-a-chip applications...
  35. ncbi Nominally stationary high-concentration solar optics by gradient-index lenses
    Panagiotis Kotsidas
    Mechanical Engineering Department, Columbia University, 220 S W Mudd Building, 500 W 120th St, New York, NY 10027, USA
    Opt Express 19:2325-34. 2011
    It is shown how novel solutions for realistic gradient-index lenses create the possibility of nominally stationary solar photovoltaic concentrators capable of daylong averaged flux concentration levels of order 10(3).
  36. ncbi Planar lenses based on nanoscale slit arrays in a metallic film
    Lieven Verslegers
    E L Ginzton Laboratory, Geballe Laboratory for Advanced Materials GLAM, Stanford University, Stanford, California 94305, USA
    Nano Lett 9:235-8. 2009
    We experimentally demonstrate planar lenses based on nanoscale slit arrays in a metallic film...
  37. ncbi A broadband zone plate lens from transformation optics
    Rui Yang
    School of Electronic Engineering and Computer Science, Queen Mary, University of London, London E1 4NS, UK
    Opt Express 19:12348-55. 2011
    ..Such a transformed lens maintains the broadband performance of the original lens, thus providing a superior alternative to the diffractive Fresnel element which is inherently narrow band...
  38. ncbi Prism adaptation changes perceptual awareness for chimeric visual objects but not for chimeric faces in spatial neglect after right-hemisphere stroke
    Margarita Sarri
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, UK
    Neurocase 12:127-35. 2006
    ..Prism therapy dramatically improved awareness for the identity of the left side of chimeric non-face objects, but had no effect on judging expressions for chimeric faces. The latter may thus be unique in showing no prism benefit...
  39. pmc Prism adaptation aftereffects in stroke patients with spatial neglect: pathological effects on subjective straight ahead but not visual open-loop pointing
    Margarita Sarri
    UCL Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC1N 3AR, UK
    Neuropsychologia 46:1069-80. 2008
    ..Future studies of possible rehabilitative impact from prisms upon neglect may need to consider carefully how to measure prism adaptation per se, separately from any impact of such adaptation upon manifestations of neglect...
  40. ncbi Dynamic changes in brain activity during prism adaptation
    Jacques Luaute
    Universite de Lyon, Universite Lyon 1, Inserm UMR S 864, 69500 Bron, France
    J Neurosci 29:169-78. 2009
    ....
  41. ncbi Functional anatomy of the therapeutic effects of prism adaptation on left neglect
    J Luaute
    INSERM Unité 534, Espace et Action, 16, avenue du doyen Lepine, 69500 Bron, France
    Neurology 66:1859-67. 2006
    ..To investigate the anatomic substrates underlying the beneficial effect of prism adaptation in five patients with persistent left neglect following right stroke...
  42. ncbi A generic camera model and calibration method for conventional, wide-angle, and fish-eye lenses
    Juho Kannala
    Department of Electrical Engineering, University of Oulu, P O Box 4500, FIN 90014, Finland
    IEEE Trans Pattern Anal Mach Intell 28:1335-40. 2006
    Fish-eye lenses are convenient in such applications where a very wide angle of view is needed, but their use for measurement purposes has been limited by the lack of an accurate, generic, and easy-to-use calibration procedure...
  43. ncbi Prism adaptation can improve contralesional tactile perception in neglect
    A Maravita
    Institute of Cognitive Neuroscience, University College, London, UK
    Neurology 60:1829-31. 2003
    ..visuospatial neglect and tactile extinction underwent 10-minute application of 20 degrees right-shifting prismatic lenses during pointing...
  44. pmc Wavefront-aberration sorting and correction for a dual-deformable-mirror adaptive-optics system
    Weiyao Zou
    School of Optometry, Indiana University, Bloomington, IN 47405, USA
    Opt Lett 33:2602-4. 2008
    ..A Lagrange multiplier is chosen to integrate two DMs into a single-DM wavefront control, and a damped least-squares control is employed to suppress the correlation between the two DMs...
  45. pmc Adaptive optics optical coherence tomography at 120,000 depth scans/s for non-invasive cellular phenotyping of the living human retina
    Cristiano Torti
    Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4LU, Wales, UK
    Opt Express 17:19382-400. 2009
    ..This novel technique provides opportunities to enhance the understanding of retinal pathogenesis and early diagnosis of retinal diseases...
  46. ncbi Nonlinear optical endoscope based on a compact two axes piezo scanner and a miniature objective lens
    R Le Harzic
    Fraunhofer Institute for Biomedical Technology IBMT, Ensheimer Strasse 48, D 66386 St Ingbert, Germany
    Opt Express 16:20588-96. 2008
    ..Results presented here demonstrate the ability of the system to resolve cellular details and the potential of the device for future in vivo imaging diagnosis...
  47. pmc Colloidal lenses allow high-temperature single-molecule imaging and improve fluorophore photostability
    Jerrod J Schwartz
    Department of Bioengineering, Stanford University and Howard Hughes Medical Institute, Stanford, California 94305, USA
    Nat Nanotechnol 5:127-32. 2010
    ..8 K), the field has since advanced to include room-temperature observations, largely owing to the use of objective lenses with high numerical aperture, brighter fluorophores and more sensitive detectors...
  48. ncbi Achieving high focusing power for a large-aperture liquid crystal lens with novel hole-and-ring electrodes
    Chi Wei Chiu
    Department of Electrical and Control Engineering, National Chiao Tung University, Hsinchu, Taiwan
    Opt Express 16:19277-84. 2008
    ..The proposed design reduces the thickness of LC lens and is capable of achieving relative higher focusing power than past studies with lower applied voltage...
  49. ncbi Vertical phoria and postural control in upright stance in healthy young subjects
    Eric Matheron
    IRIS Group CNRS FRE 3154 Service d Ophtalmologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France
    Clin Neurophysiol 119:2314-20. 2008
    ..To test the quality of postural performance in quiet upright stance in healthy young adults with vertical heterophoria (VH) within the normal range and without VH (vertical orthophoria, VO)...
  50. pmc Adjustable fluidic lenses for ophthalmic corrections
    Randall Marks
    College of Optical Sciences, University of Arizona, Tucson, Arizona 86721, USA
    Opt Lett 34:515-7. 2009
    We report on two fluidic lenses that have been developed for ophthalmic applications...
  51. ncbi Effects of ocular dominance on the vertical vergence induced by a 2-diopter vertical prism during standing
    Eric Matheron
    Service d Ophtalmologie Hôpital Européen Georges Pompidou, Paris Cedex 15, France
    Neurosci Lett 444:176-80. 2008
    ..e. 1.14 degrees ) when the prism was on the NDE for both distances, but more appropriate when the prism was on the DE. The results suggest that sensory disparity process and vertical vergence responses are modulated by eye dominance...
  52. ncbi Design, assembly, and optical bench testing of a high-numerical-aperture miniature injection-molded objective for fiber-optic confocal reflectance microscopy
    Matthew D Chidley
    College of Optical Sciences, University of Arizona, Tucson 85721, USA
    Appl Opt 45:2545-54. 2006
    ..Disposable endoscopic microscope objectives could help in vivo confocal microscopy technology mature to permit wide-scale clinical screening and detection of early cancers and precancerous lesions...
  53. pmc Compact adaptive optics line scanning ophthalmoscope
    Mircea Mujat
    Physical Sciences Inc, 20 New England Business Center, Andover, MA 01810, USA
    Opt Express 17:10242-58. 2009
    ..In addition to instrument design, fabrication, and testing, software algorithms were developed for automated image registration and cone counting...
  54. pmc Refractive state of tree shrew eyes measured with cortical visual evoked potentials
    Thomas T Norton
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, 606 Worrell Building, Birmingham, AL 35294 4390, USA
    Optom Vis Sci 80:623-31. 2003
    ..To determine the refractive state of tree shrew eyes using visual evoked potentials (VEP's) recorded from primary visual cortex and compare the values with those obtained with streak retinoscopy and with an autorefractor...
  55. pmc Low cost, high performance, self-aligning miniature optical systems
    Robert T Kester
    Department of Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005, USA
    Appl Opt 48:3375-84. 2009
    ..71. This universal technology is now being developed for smaller, needle-sized imaging systems and other portable point-of-care diagnostic instruments...
  56. ncbi Effects of a two-diopter vertical prism on posture
    Eric Matheron
    IRIS Group, CNRS MR 7152, College de France, 11 place M Berthelot, 75005 Paris, France
    Neurosci Lett 423:236-40. 2007
    ....
  57. ncbi Adaptive liquid microlenses activated by stimuli-responsive hydrogels
    Liang Dong
    Department of Electrical and Computer Engineering, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 442:551-4. 2006
    ..In contrast, traditional man-made optical systems achieve focusing by physical displacement of the lenses used...
  58. pmc High-throughput lens-free blood analysis on a chip
    Sungkyu Seo
    Electrical Engineering Department, University of California, Los Angeles, California 90095, USA
    Anal Chem 82:4621-7. 2010
    ..These results uncover the prospects of lens-free holographic on-chip imaging to provide a useful tool for global health problems, especially by facilitating whole blood analysis in resource-poor environments...
  59. ncbi Disposable microscope objective lenses for fluorescence correlation spectroscopy using latex microspheres
    Jerome Wenger
    Institut Fresnel, Aix Marseille Universite, CNRS, 13397 Marseille, France
    Anal Chem 80:6800-4. 2008
    ..Viable FCS experiments at concentrations 1-1000 nM with different objectives costing less than $40 are demonstrated. This offers a simple and low-cost alternative to the conventional complex microscope objectives...
  60. ncbi Multifocal lenses compensate for chromatic defocus in vertebrate eyes
    R H Kröger
    Anatomisches Institut, Eberhard Karls Universitat Tubingen, Germany
    J Comp Physiol A 184:361-9. 1999
    ..To solve this problem, fishes with irises unresponsive to light have developed lenses with multiple focal lengths...
  61. ncbi Prism adaptation overcomes pseudoneglect for the greyscales task
    Andrea M Loftus
    School of Behavioural Science, University of Melbourne, Vic, Australia
    Cortex 45:537-43. 2009
    ..The findings demonstrate that a simple visuomotor task can alter the distribution of spatial attention for the greyscales task in normal participants...
  62. ncbi Micro-optical artificial compound eyes
    J W Duparré
    Fraunhofer Institute for Applied Optics and Precision Engineering, Jena, Germany
    Bioinspir Biomim 1:R1-16. 2006
    ..The artificial apposition compound eye can be considered as a simple imaging optical sensor while the cluster eye is capable of becoming a valid alternative to classical bulk objectives but is much more complex than the first system...
  63. pmc Hybrid reflecting objectives for functional multiphoton microscopy in turbid media
    Dejan Vucinic
    Howard Hughes Medical Institute, Computational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Opt Lett 31:2447-9. 2006
    ..We model the performance of one such design optimized for a typical brain-imaging setup and show that it can greatly outperform objectives commonly used for this task...
  64. ncbi Prism adaptation and unilateral neglect: review and analysis
    Gordon M Redding
    Department of Psychology, Illinois State University, Campus Box 4620, Normal, IL 61790 4620, USA
    Neuropsychologia 44:1-20. 2006
    ..Investigation of therapeutic prism adaptation requires methods that permit identification of both the calibration dysfunction and ameliorating realignment...
  65. pmc Holographic opto-fluidic microscopy
    Waheb Bishara
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Opt Express 18:27499-510. 2010
    ..has also expanded into optics to create reconfigurable and flexible optical devices such as reconfigurable lenses, lasers, waveguides, switches, and on-chip microscopes. Here we present a new opto-fluidic microscopy modality, i...
  66. pmc Error budget analysis for an adaptive optics optical coherence tomography system
    Julia W Evans
    Department of Ophthalmology and Vision Science, Vision Science and Advanced Retinal Imaging Laboratory, University of California, Davis, Sacramento, CA 95817, USA
    Opt Express 17:13768-84. 2009
    ..We also discuss the scaling of error sources for different subjects and the need to improve the robustness of the system by addressing subject variability...
  67. ncbi Recovery of oculo-motor bias in neglect patients after prism adaptation
    Valentina Angeli
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Bologna, Italy
    Neuropsychologia 42:1223-34. 2004
    ..before and after PA were then compared to that of control neglect patients, who were wearing goggles with neutral lenses. Moreover, in order to provide normative data on ocular scanning behaviour during letter string reading, ..
  68. ncbi Postoperative complications following vitrectomy for proliferative diabetic retinopathy with sew-on and noncontact wide-angle viewing lenses
    S R Virata
    Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, USA
    Ophthalmic Surg Lasers 32:193-7. 2001
    ..To compare the occurrence of vitreous hemorrhages and retinal detachments following vitrectomy surgery with sew-on lenses to a noncontact wide-angle lens system...
  69. pmc Color and monochrome lensless on-chip imaging of Caenorhabditis elegans over a wide field-of-view
    Serhan O Isikman
    Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA
    Lab Chip 10:1109-12. 2010
    ..This wide field-of-view and compact on-chip imaging modality also permits straightforward integration with microfluidic systems...
  70. ncbi Mechanisms underlying visuo-spatial amelioration of neglect after prism adaptation
    Valentina Angeli
    Centro di Neuroscienze Cognitive, Cesena, Italy
    Cortex 40:155-6. 2004
  71. ncbi Characterization of microscope objective lenses from 1,400 to 1,650 nm to evaluate performance for long-wavelength nonlinear microscopy applications
    Stefanie Renaud Keatings
    Centre for Biophotonics, Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0NR, United Kingdom
    Microsc Res Tech 71:517-20. 2008
    ..We investigated a range of air and oil-immersion objective lenses across a wavelength range of 1,400-1,650 nm using a synchronously pumped optical parametric oscillator laser ..
  72. pmc High-accuracy wavefront control for retinal imaging with Adaptive-Influence-Matrix Adaptive Optics
    Weiyao Zou
    School of Optometry, Indiana University, 800 East Atwater Avenue, Bloomington, Indiana 47405, USA
    Opt Express 17:20167-77. 2009
    ..The AIM method is most useful in AO modalities where there are large static contributions to the wavefront aberrations...
  73. ncbi Data quality dependencies in microring-based DPSK transmitter and receiver
    Lin Zhang
    Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    Opt Express 16:5739-45. 2008
    ..Transmission performance of the all-microring-based DPSK signal over a 70-km single mode fiber is compared to that of DPSK using a Mach-Zehnder modulator and a delay-line interferometer...
  74. ncbi Super resolution imaging by compensating oblique lens with metallodielectric films
    Yanhui Zhao
    State Key Laboratory of Optical Technologies for Microfabrication, Institute of Optics and Electronics, Chinese Academy of Sciences, P O Box 350, Chengdu 610209, China
    Opt Express 16:5697-707. 2008
    ..Super resolution optical imaging can be obtained with uniform light intensity and tunable magnification by changing parameters of the structure. Design principles and examples are given and illustrated with numerical simulation...
  75. ncbi Protecting a lens with air
    Tai Shan Liao
    Instrument Technology Research Center, National Applied Research Laboratories, Taiwan, Republic of China
    Rev Sci Instrum 78:056101. 2007
    ..An experimental wireless video camera debris deflecting system was realized and performed to verify the concept. Functional tests have been successfully verified...
  76. ncbi Mirror slides for high-sensitivity cell and tissue fluorescence imaging
    Eric Le Moal
    Université Denis Diderot Paris VII, UMR 7162 CNRS, Laboratoire Matériaux et Phénomènes Quantiques, Paris Cedex, France
    J Biomed Opt 12:024030. 2007
    ....
  77. ncbi Distance optical sensor for quantitative endoscopy
    Agnese Lucesoli
    Universita Politecnica delle Marche, Dipartimento di Elettromagnetismo e Bioingegneria, Via Brecce Bianche, Ancona, Italy
    J Biomed Opt 13:010504. 2008
    ..It showed high sensitivity, providing correct and repeatable distance measurements on biological samples even in case of very low reflected power (down to 2 to 3 nW), with an error lower than 0.1 mm...
  78. ncbi Fluorescence multicolor hologram recorded by using a macrolens array
    Natan T Shaked
    Department of Electrical and Computer Engineering, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
    Opt Lett 33:1461-3. 2008
    ..The 3-D reconstructed images from all the monochromatic holograms are composed into a single multicolor image of the 3-D scene. The proposed holographic technique is demonstrated by experiments...
  79. ncbi Role of optics in the accuracy of depth-from-defocus systems
    Ilya Blayvas
    Computer Science Department, Technion Israeli Institute of Technology, Haifa 32000, Israel
    J Opt Soc Am A Opt Image Sci Vis 24:967-72. 2007
    ..We also provide guidelines for the design of new depth-from-defocus systems in compliance with predefined specifications by choosing the appropriate optics...
  80. ncbi Lens-focused transducer modeling using an extended KLM model
    Pierre Maréchal
    François Rabelais University of Tours, LUSSI, ENIVL, BLOIS Cedex, France
    Ultrasonics 46:155-67. 2007
    ....
  81. pmc I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions
    Lin Shao
    Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco, California, USA
    Biophys J 94:4971-83. 2008
    ..in all three dimensions, by using structured illumination in a microscope that has two opposing objective lenses. Illumination light is split by a grating and a beam splitter into six mutually coherent beams, three of which ..
  82. ncbi Photon signal detection and evaluation in the adaptive optics scanning laser ophthalmoscope
    Yuhua Zhang
    School of Optometry, University of California, Berkeley 94720 2020, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1276-83. 2007
    ..The study presents a practical strategy that can be used to test the photodetector for either initial evaluation or subsequent performance in in-line inspection...
  83. pmc Effect of aberrations and scatter on image resolution assessed by adaptive optics retinal section imaging
    Justin M Wanek
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago 60612, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1296-304. 2007
    ..The findings of the current study suggest that AO imaging systems can potentially improve image resolution in aging eyes with increased aberrations and scatter...
  84. ncbi High-resolution adaptive optics scanning laser ophthalmoscope with dual deformable mirrors
    Diana C Chen
    Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1305-12. 2007
    ....
  85. pmc Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope
    Stephen A Burns
    School of Optometry, Indiana University, Bloomington 47405, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1313-26. 2007
    ..The retinal image was stabilized to within 18 microm 90% of the time. Stabilization was sufficient for cross-correlation techniques to automatically align the images...
  86. ncbi Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging
    Chad E Bigelow
    Physical Sciences Inc, Andover, MA 01810, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1327-36. 2007
    ..In human volunteer testing, we observed up to an 8 dB increase in OCT signal and a corresponding lateral resolution of <10 microm as a result of AO correction...
  87. ncbi Analysis of the angular acceptance of surface plasmon Bragg mirrors
    María Ujué González
    ICFO Institut de Ciencies Fotoniques, Mediterranean Technology Park, 08860, Castelldefels Barcelona, Spain
    Opt Lett 32:2704-6. 2007
    ..This effect, which can considerably affect the design of devices based on these elements, is shown to be the consequence of the decrease of the bandgap width with increasing incidence angle...
  88. ncbi A new microscope optics for laser dark-field illumination applied to high precision two dimensional measurement of specimen displacement
    Naoki Noda
    Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3 8 1, Meguro, Tokyo 153 8902, Japan
    Rev Sci Instrum 79:023704. 2008
    ..For the microscopy, we used a laser beam and a pair of axicons (conical lenses) to get an optimal condition for dark-field observations...
  89. ncbi Rhodium coated mirrors deposited by magnetron sputtering for fusion applications
    L Marot
    Department of Physics, University of Basel, Klingelbergstrasse 82, CH 4056 Basel, Switzerland
    Rev Sci Instrum 78:103507. 2007
    ..Detailed optical characterizations of Rh-coated mirrors as well as results of erosion tests performed both under laboratory conditions and in the TEXTOR tokamak are presented in this paper...
  90. ncbi Cover slip external cavity diode laser
    Adra V Carr
    Department of Physics, University of Arizona, Tucson, Arizona, 85721, USA
    Rev Sci Instrum 78:106108. 2007
    ..This system is simple, economical, robust, and easy to use for spectroscopy, as we demonstrate with lithium vapor and lithium atom beam experiments...
  91. ncbi Correction of low order aberrations using continuous deformable mirrors
    Gleb Vdovin
    Flexible Optical BV OKO Technologies, Röntgenweg 1, 2624 BD Delft, The Netherlands
    Opt Express 16:2859-66. 2008
    ....
  92. ncbi Micro-optical polarizer with high efficiency
    Patrick Ruffieux
    University of Neuchâtel Institute of Microtechnology
    Opt Express 16:2023-36. 2008
    ..Combined with a patterned twisted nematic (TN) cell, allowing a rotation of only one polarization component, a polarizer with high efficiency (72,5% (measured) is realized. Simulations and measurements are presented...
  93. ncbi Changes of optical properties of retroreflector installed in LHD
    T Akiyama
    National Institute for Fusion Science, 322 6 Oroshi cho, Toki shi, Gifu 509 5292, Japan
    Rev Sci Instrum 78:103501. 2007
    ..The parallelism of the reflected beam to an incident one also deteriorated. The changes in the polarization angle and in the ellipticity of reflected light polarization were not observed from the visible to the far infrared range...
  94. ncbi Ultrafast laser writing of homogeneous longitudinal waveguides in glasses using dynamic wavefront correction
    C Mauclair
    Laboratoire Hubert Curien, UMR 5516 CNRS, Université Jean Monnet, 42000 Saint Etienne, France
    Opt Express 16:5481-92. 2008
    ..The corrective process becomes increasingly important when laser energy has to be transported without losses at arbitrary depths, with the purpose of triggering mechanisms of positive refractive index change...
  95. ncbi 4Pi spectral self-interference microscopy
    Brynmor J Davis
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 24:3762-71. 2007
    ..Specifically, SSM is shown to be subject to the same resolution constraints as 4Pi microscopy...
  96. ncbi Simultaneous measurement of refractive index and thickness by combining low-coherence interferometry and confocal optics
    Seokhan Kim
    Department of Information and Communications, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju, 500 712, Korea
    Opt Express 16:5516-26. 2008
    ..The average measurement errors of the first and the second methods were 0.123% and 0.061% in the geometrical thickness, 0.133% and 0.066% in the phase index, and 0.106% and 0.057% in the group index, respectively...
  97. ncbi Modified Gaussian influence function of deformable mirror actuators
    Linhai Huang
    Institute of Optics and Electronics, Chinese Academy of Sciences P O Box 350, Shuangliu, Chengdu 610209, China
    Opt Express 16:108-14. 2008
    ..The result indicates that the modified Gaussian influence function provides much better performance in data fitting...
  98. ncbi Active focus locking in an optically sectioning microscope utilizing a deformable membrane mirror
    S P Poland
    Institute of Photonics, SUPA, University of Strathclyde, Glasgow, Scotland, UK
    Opt Lett 33:419-21. 2008
    ..We were able to track focus over a 400 microm range (limited by the range of the piezomounted objective) with a rms precision on the focal depth of 0.31 microm +/- 0.05 microm...
  99. ncbi A laser guide star wavefront sensor bench demonstrator for TMT
    Olivier Lardiere
    AO Laboratory, Mechanical Engineering Department, University of Victoria, PO Box 3055 STN CSC, Victoria, BC, V8W 3P6, Canada
    Opt Express 16:5527-43. 2008
    ..This bench is not limited to SH-WFS and can serve as an LGS-simulator test bed to any other LGS-AO projects for which sodium layer fluctuations are an issue...
  100. ncbi Two dimensional photoacoustic imaging based on an acoustic lens and the peak-hold technology
    Hanchao Zhang
    School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006, People s Republic of China
    Rev Sci Instrum 78:064902. 2007
    ..Compared to other methods, this PA imaging system can acquire the PA images more rapidly without any complex algorithms, and it may provide a more convenient method for future in vivo noninvasive imaging of tissues and clinic diagnosis...
  101. ncbi Wide-band acousto-optic deflectors with high efficiency for visible range fringe pattern projector
    S Dupont
    IEMN DOAE, UMR 8520, Le Mont Houy, 59313 Valenciennes Cedex 09, France
    Rev Sci Instrum 78:105102. 2007
    ..The spatial period of the interference fringes can be dynamically controlled over almost one decade by tuning the frequency of the acoustic carriers...

Research Grants68

  1. GENE MANIPULATION & H202 DEGRADATION IN THE OCULAR LENS
    Abraham Spector; Fiscal Year: 2001
    ..Analyses will be carried out in organ culture with lenses from normal, transgenic and knockout lines. The effect of aging will be examined...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..The patches are removed, the surface of the eyes is numbed, and contact lenses that can sense signals from the retina are placed on the eyes. The subject then watches flashing lights...
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..The patches are removed, the surface of the eyes is numbed, and contact lenses that can sense signals from the retina are placed on the eyes. The subject then watches flashing lights...
  4. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  5. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
    ..The ability of Fusarium to form biofilms on contact lenses/lens cases was suggested to be one of the factors that contributed to the recent Fusarium keratitis outbreak...
  6. DEVELOPMENT AND MAINTENANCE OF LENS TRANSPARENCY
    JOHN IRWIN CLARK; Fiscal Year: 2013
    ..AIM 2 will use slit lamp imaging to conduct phenotype analyses of lenses in transgenic mouse models for neurodegenerative and neuromuscular disorders...
  7. VOLUME REGULATION IN NORMAL AND CATARACTOUS LENSES
    Richard T Mathias; Fiscal Year: 2013
    ..the spatial distribution of intracellular hydrostatic pressure, and intracellular sodium and calcium in intact lenses. Most studies involve lenses from genetically altered mice that express modified transport proteins or other ..
  8. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..such as proparacaine and benzalkonium chloride) and delivery (devices such as merocel sponges, hydrogel contact lenses, and collagen shields) will be studied. In aim 4, topical cross-linking of live rabbits will be undertaken...
  9. Membrane skeleton regulation of cell shape and interactions in lens development
    Velia M Fowler; Fiscal Year: 2013
    ..Tmod1-/- lenses are transparent, but Tmod2 levels are elevated, suggesting partial compensation...
  10. AMINO-CARBONYL REACTIONS IN THE AGING HUMAN LENS
    Vincent M Monnier; Fiscal Year: 2013
    ..mouse which expresses humanized levels of ascorbic acid in the lens, 2) the demonstration that within 12 mos the lenses turn yellow and accumulate all ascorbylation products present in the human lens, 3) the discovery that both oral ..
  11. TRACE ELEMENT DYNAMICS IN THE VERTEBRATE EYE
    MARY C MCGAHAN; Fiscal Year: 2013
    ..Furthermore, there are profound changes in the structure of the iron storage protein ferritin in lenses that occur with age, cataractogenesis and differentiation...
  12. Development Of An Eye Drop To Treat Presbyopia
    William H Garner; Fiscal Year: 2012
    ..loss of near vision after age of 40 presents with limited treatment options including eyeglasses, contact lenses, or Lasik surgery...
  13. Mechanotransduction in the Ciliary Muscle
    Andrew D Pucker; Fiscal Year: 2013
    ..We chose the guinea pig model because the guinea pig can accommodate, and because spectacle lenses can induce a significant amount of myopia...
  14. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..Keratoconus affects 1 in 2000. 35M Americans wear contact lenses and approximately 3M Americans undergo some sort of refractive surgery each year...
  15. Peroxiredoxin 6 and Cataractogenesis
    Dhirendra P Singh; Fiscal Year: 2010
    ..Using targeted inactivation of Prdx6 gene in mice, we found that Prdx6-depleted lenses and/or lens epithelial cells (LECs) contain elevated levels of ROS and bio-activeTGF21;exhibit phenotypic changes ..
  16. MECHANISMS OF OCULAR DEVELOPMENT
    Thomas T Norton; Fiscal Year: 2012
    ..Although glasses, contact lenses and refractive surgery can provide an optical correction, the increased axial length of the eye significantly ..
  17. Diversity and Dynamic Stability of the Ocular Surface Microbiome
    Russell N Van Gelder; Fiscal Year: 2013
    ..OS microbiome (specifically, treatment with topical antibiotics, topical corticosteroids, and use of soft contact lenses) will be tested using these same techniques...
  18. Fast-Switching, High-Contrast, Electrochromic Sunwear for Persons with Age-Relate
    PRASANNA CHANDRASEKHAR; Fiscal Year: 2011
    ..2) Very slow-switching (2 - 5 minutes) photochromic lenses which need UV light for activation...
  19. Leica TCS SP5 MP confocal and two-photon microscope
    Martin D Brand; Fiscal Year: 2012
    ..Since this is mounted on an Axiovert 200 which is an inverted microscopic system, with lenses and internal, descanned detectors with filter-wheel based spectral selection optimized for cell culture and ..
  20. Identifying mechanisms of translocation of epithelial cells by P. aeruginosa.
    DANIELLE KRISTY AUGUSTIN; Fiscal Year: 2010
    ..of the mechanisms by which bacteria reach the stroma after adherence to corneal epithelial cells and how contact lenses increase the incidence of P. aeruginosa infection...
  21. PROTEINS OF NORMAL AND CATARACTOUS LENSES
    FRANK JOSEPH GIBLIN; Fiscal Year: 2012
    ..and disappearance of truncated crystallin fragments in various regions of thin tissue sections of guinea pig lenses, as a function of age and HBO- treatment...
  22. cdiGMP regulation of Biofilm Formation
    GEORGE A O'TOOLE; Fiscal Year: 2013
    ..resistant biofilms on a broad range of medical implant such as catheters, orthopedic implants and contact lenses is a significant clinical problem...
  23. MULTIPHOTON CONFOCAL MICROSCOPE
    Liza A Pon; Fiscal Year: 2010
    ..Finally, the system is cost-effective, as we can take ad- vantage of existing accessories (e.g. lenses, DIC optics, and environmental control for live-cell imaging)...
  24. Fiber Cell Cytoskeletal Scaffolds-Role in Lens Architecture and Function
    P Vasantha Rao; Fiscal Year: 2011
    ..optical quality, fiber cell shape, packing and membrane integrity using PRX null and conditional knockout mouse lenses. The completion of these studies is expected to provide novel insights into the broad significance of cortical ..
  25. Mechanisms of lens growth regulation
    Xiaohua Gong; Fiscal Year: 2013
    ..Mutant lenses display drastically reduced growth after weaning age and stop growing at the age of 8 weeks...
  26. Role of the Foxe3 Gene Family in Lens Formation.
    MILAN ALEXANDER JAMRICH; Fiscal Year: 2013
    ..that belong to the Foxe3 lens regulatory network by comparing transcriptomes of wild type and Foxe3-deficient lenses using deep RNA-sequencing...
  27. The role of DNA methylation in lens fiber cell terminal differentiation
    Rachel K Tittle; Fiscal Year: 2012
    ..My preliminary data show that loss of Dnmt1 and Uhrf1 function leads to cataracts and morphologically abnormal lenses that contain disorganized and apoptotic lens fibers...
  28. Feasibility study: endoscopic surface-enhanced Raman spectroscopy (SERS) for in s
    Martin Feldman; Fiscal Year: 2013
    ..be examined by using a Raman spectrometer system built in-house, which consists of a laser, a dichroic mirror, lenses, a linear CCD array, and a computer...
  29. Ocular Drug Delivery Devices for Improved Postoperative Cataract Care
    Buddy D Ratner; Fiscal Year: 2010
    ..Tremendous advances have been made both in the design of the IOL and in the surgical procedure. The newest lenses can correct refractive errors and some lenses are beginning to appear that have the potential to restore ..
  30. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..We will refer to such structures as plasmonic lenses. The results from the FDTD simulations will be used to select specific geometries for nanofabrication...
  31. Imaging and stimulation of neural activity at cellular resolution in awake mice
    David W Tank; Fiscal Year: 2012
    ..first generation instrument, and extend its capabilities by adding real-time motion correction, new chambers and lenses for imaging of deeper brain structures such as the hippocampus, and the incorporation of a visual virtual reality ..
  32. MRI Biometry of the Pseudophakic Cadaver Eye
    Susan A Strenk; Fiscal Year: 2010
    ..include lens refilling, scleral treatments, and, most notably, the development of accommodating intraocular lenses (IOLs)...
  33. AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGING
    Lee E Goldstein; Fiscal Year: 2010
    ..We have recently identified AB in human lenses and detected AB deposition, amyloid pathology, and co-localizing equatorial supranuclear cataracts (SNC) in lenses ..
  34. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..answers for the following questions, using specific fluorescent dyes with confocal readout in living extirpated lenses, protein specific antibodies in lens tissue sections, clonal growth capacity in LEC cultures, LEC chromosome ..
  35. CELL JUNCTIONS AND CELL MEMBRANES IN THE LENS
    WOO KUEN K LO; Fiscal Year: 2011
    ..focus on identification of key lipid and protein components of lipid rafts in IDs of embryonic and adult chicken lenses. Because IDs share several unique features with lipid rafts of other cells, we hypothesize that the lens-specific ..
  36. Myopia: the role of cone opsin mutations &glasses that control axial elongation
    Jay Neitz; Fiscal Year: 2013
    ..Both lenses had the individual's optimal correction...
  37. FIBER CELL JUNCTIONS IN NORMAL AND CATARACTOUS LENSES
    M Joseph Costello; Fiscal Year: 2011
    ..The particles were found to be more numerous in nuclear cataracts than age-matched transparent donor lenses. A method of quantitative electron absorption was developed to measure the local protein concentration and ..
  38. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2013
    ..Recently, my laboratory has developed a technique for producing a viable, isolated fiber cell preparation from lenses of adult and neonatal mice...
  39. Drug Eluting Contact Lenses
    Joseph B Ciolino; Fiscal Year: 2013
    ..In addition, bandage contact lenses are often used in conjunction with antibiotics...
  40. ImageStream X Analyzer 2011
    FREDERIC IRA PREFFER; Fiscal Year: 2012
    ..in this resubmission to purchase a 5-laser 2-camera Amnis ImageStreamX with three (20x, 40x, 60x) objective lenses. This new platform is a vastly improved, refined and far more powerful version of the original instrument Amnis ..
  41. The Regulation of Lens Fiber Cell Differentiation
    Melinda K Duncan; Fiscal Year: 2012
    ..visual outcome for patients, particularly those fitted with the newest generation of accommodating intraocular lenses. These studies seek to elucidate the transcriptional mechanisms responsible for normal lens fiber cell ..
  42. A DATABASE OF IOL POSITION AND BEHAVIOR
    Susan A Strenk; Fiscal Year: 2010
    ..include lens refilling, scleral treatments, and, most notably, the development of accommodating intraocular lenses (A-IOLs)...
  43. System for Ocular Oxygen Measurements
    BRUCE M ISHIMOTO; Fiscal Year: 2011
    ..research and will lead to advancements in our understanding of ocular diseases, development of new drugs, contact lenses and surgical procedures...
  44. STRUCTURAL MODELS FOR MOLYBDOENZYMES
    John H Enemark; Fiscal Year: 2011
    ..These symptoms include dislocated ocular lenses, mental retardation, and, in severe cases, attenuated growth of the brain and early death...
  45. Molecular Analysis of Microdissected Human Lenses
    Marc Kantorow; Fiscal Year: 2013
    ..The information gained from this work will have a major impact on the rational design of therapeutics that could prevent cataract formation. ..
  46. Carl Zeiss AxioImager Z1 Research Microscope
    Mary E Blue; Fiscal Year: 2010
    ..years by a large number of users, that is showing considerable wear and tear, and for which replacement parts and lenses are no longer available...
  47. Novel Mechanism of Induction of Eye Tissue: Katp Channel Modulation
    Michael Levin; Fiscal Year: 2010
    ..The phenotypes range from isolated retina tissue and lenses, to complete eyes formed in many ectopic locations (including on the gut and tail)...
  48. Optical probe for microscopic cancer identification in minute structures
    Martin Feldman; Fiscal Year: 2010
    ..This proposal is to construct a compact optical system using the graded index (GRIN) lenses often found in endoscopic probes...
  49. Crystallin-Derived Anti-Chaperones in the Lens
    Krishna K Sharma; Fiscal Year: 2013
    ..Aged and cataractous human lenses show increased crystallin proteolysis and aggregation as compared to young, non-cataractous lenses...
  50. Mid-Level Vision Systems for Low Vision
    Norberto M Grzywacz; Fiscal Year: 2011
    Low vision is a significant reduction of visual function that cannot be fully corrected by ordinary lenses, medical treatment, or surgery. Aging, injuries, and diseases can cause low vision...
  51. Molecular Mechanisms of Protein Crosslinking in the Lens
    Ram H Nagaraj; Fiscal Year: 2013
    ..Protein crosslinking is a major modification in aged and cataractous lenses. Ascorbate (ASC) is a major constituent of the lens, which in the human lens is present at concentrations up to 2 ..
  52. ACCOMMODATIVE CONTACT LENs FOR PRESBYOPIC CORRECTION
    Hongrui Jiang; Fiscal Year: 2011
    ..I seek a paradigm-shifting approach to the correction of presbyopia by developing accommodative contact lenses (ACL)...
  53. ROLE OF EPHRIN-A5 IN LENS FIBER CELL ORGANIZATION
    ALEXANDER INHA SON; Fiscal Year: 2012
    ..We first plan to test this hypothesis by defining the morphological changes between wild-type and ephrin-A5 null lenses in regards to age...
  54. BIOLOGY OF LENS INTERCELLULAR COMMUNICATION
    Eric C Beyer; Fiscal Year: 2013
    ..class of connexin mutants in lens cells (of chicken embryos, stably transfected lens epithelial cell lines, or lenses of mice carrying connexin mutations)...
  55. A novel therapeutic for the treatment of persistent corneal epithelial defects
    Bennie H Jeng; Fiscal Year: 2010
    ..of aggressive lubrication with preservative-free artificial tears and ointments, the use of bandage soft contact lenses, pressure patching, punctal plugging, and the surgical closure of the eyelids...
  56. FIBER CELL FORMATION IN NORMAL AND CATARACTOUS LENSES
    Steven Bassnett; Fiscal Year: 2013
    ..These experiments are expected to provide important insights into the control of lens growth and the etiology of cortical cataract in humans. ..
  57. Adaptive Optics Retinal Imaging in a Clinical Setting Using Long Stroke Wavefront
    PAUL ARTHUR BIERDEN; Fiscal Year: 2013
    ..allow aberration- compensated imaging suitable for 90% of clinical subjects without the use of added trial lenses. In Phase II work, the AOSLO was demonstrated to achieve exceptional retinal image resolution and operational ..
  58. Proteinase Inhibitors and Crystallin Fragments in Cataract
    OM PRAKASH SRIVASTAVA; Fiscal Year: 2013
    ..Because mainly human lenses will be used in these studies, the findings will be relevant to in vivo mechanism of age-related cataract ..
  59. Mechanisms underlying emmetropization and local eye growth regulation
    CHRISTINE FRANCES WILDSOET; Fiscal Year: 2012
    ..by simultaneous, competing myopic and hyperopic defocus produced by several types of multifocal and astigmatic lenses. We will evaluate hypotheses regarding retinal processing, optical aberrations, and peripheral retinal growth to ..
  60. Optical aberration and visual performance in highly aberrated eyes
    Raymond A Applegate; Fiscal Year: 2012
    ..in ocular wavefront sensing and ophthalmic lens lathing has demonstrated that custom wavefront-guided soft contact lenses can be designed and manufactured for the highly aberrated eye...
  61. Gene Discovery in Mouse Models for Secondary Cataracts
    Panagiotis A Tsonis; Fiscal Year: 2011
    ..established will be compared with each other and with databases established from developing, adult and cataractous lenses. This research will eventually identify gene patterns of known and novel genes that are involved in EMT and PCO as ..
  62. Electro-optic adaptive eyeglass for correction of presbyopia
    Guoqiang Li; Fiscal Year: 2013
    ..More than 90% of the people over 45 need correction of presbyopia. The conventional corrective lenses (bifocal, trifocal) have been around for more than 200 years and have some drawbacks...
  63. EPIKERATOPHAKIA: THE SURGICAL CORRECTION OF APHAKIA
    MARGUERITE MC DONALD; Fiscal Year: 1991
    Epikeratophakia was developed for the correction of aphakia in adult patients unable to tolerate contact lenses and not candidates for secondary implantation of intraocular lenses, and adapted for use in infants and children with ..
  64. ATP LINKED EFFECTORS OF NA+, K+ ATPASE AND CATARACTS
    MARGARET GARNER; Fiscal Year: 2001
    ..Historically, increased lens Na+ concentrations, common in human cataract lenses, were believed to result from the dysfunction of membrane Na+ transport systems of the lens epithelium...
  65. Biofilm Formation And P. aeruginosa infection of the eye
    Michael Zegans; Fiscal Year: 2006
    ..the eye can have vision-threatening complications and often are associated with prosthetic devices such as contact lenses, scleral buckles, and intraocular lenses...
  66. CONTACT LENSES AND MYOPIA (CLAMP) STUDY
    JEFFREY WALLINE; Fiscal Year: 2003
    The Contact Lenses and Myopia Progression (CLAMP) Study will serve two purposes: 1) it will provide the training mechanism for Jeffrey J. Walline, O.D...
  67. Nanosphere-Antibiotic Corneal Contact Lens Delivery System
    CHARLES LEAHY; Fiscal Year: 2009
    ..wound healing at the surface of the eye, as is commonly done using current, non-medicated hydrogel bandage contact lenses. The nanosphere technology utilized in this project allows for customized encapsulation to control drug release...
  68. APOPTOSIS--LENS DIFFERENTIATION AND CATARACT DEVELOPMENT
    David Li; Fiscal Year: 2000
    ..Our recent studies of the lens epithelial cell viability in human normal and cataractous lenses and in rat lenses with or without insult by oxidative stress, calcimycin and UVB consistently suggest that induced ..