microelectrodes

Summary

Summary: Electrodes with an extremely small tip, used in a voltage clamp or other apparatus to stimulate or record bioelectric potentials of single cells intracellularly or extracellularly. (Dorland, 28th ed)

Top Publications

  1. ncbi Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
    R D Braun
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 280:H2533-44. 2001
  2. ncbi Large-scale recording of neuronal ensembles
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 7:446-51. 2004
  3. pmc Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation
    Mark H Histed
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 63:508-22. 2009
  4. ncbi Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes
    M J Shattock
    Division of Biomedical Sciences, University of California, Riverside 92521 0121
    Am J Physiol 256:C813-22. 1989
  5. pmc In situ analysis of nitrifying biofilms as determined by in situ hybridization and the use of microelectrodes
    S Okabe
    Department of Urban and Environmental Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060 0813, Japan
    Appl Environ Microbiol 65:3182-91. 1999
  6. pmc Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array
    J D Simeral
    Rehabilitation R and D Service, Department of Veterans Affairs Medical Center, Providence, RI 02912, USA
    J Neural Eng 8:025027. 2011
  7. ncbi In-cell recordings by extracellular microelectrodes
    Aviad Hai
    Department of Neurobiology, Life Science Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    Nat Methods 7:200-2. 2010
  8. ncbi Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks
    Jaap van Pelt
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Neurons and Networks Research Group, 1105 AZ Amsterdam, The Netherlands
    IEEE Trans Biomed Eng 51:2051-62. 2004
  9. ncbi Real-time cell electrophysiology using a multi-channel dielectrophoretic-dot microelectrode array
    Henry O Fatoyinbo
    Centre for Biomedical Engineering, School of Engineering, University of Surrey, Guildford, UK
    Electrophoresis 32:2541-9. 2011
  10. ncbi Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mov Disord 21:S259-83. 2006

Detail Information

Publications319 found, 100 shown here

  1. ncbi Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
    R D Braun
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 280:H2533-44. 2001
    In this study we compare oxygen tension (PO2) histograms measured with O2 microelectrodes and a new optical PO2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) (n = 5-6)...
  2. ncbi Large-scale recording of neuronal ensembles
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 7:446-51. 2004
    ....
  3. pmc Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation
    Mark H Histed
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 63:508-22. 2009
    ..Our results indicate that the pattern of activated neurons likely arises from the direct activation of axons in a volume tens of microns in diameter...
  4. ncbi Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes
    M J Shattock
    Division of Biomedical Sciences, University of California, Riverside 92521 0121
    Am J Physiol 256:C813-22. 1989
    ..movements in rabbit and rat ventricular muscle were compared using extracellular double-barreled Ca-selective microelectrodes. In rabbit ventricle, steady-state twitches were associated with transient extracellular Ca (Cao) depletions, ..
  5. pmc In situ analysis of nitrifying biofilms as determined by in situ hybridization and the use of microelectrodes
    S Okabe
    Department of Urban and Environmental Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060 0813, Japan
    Appl Environ Microbiol 65:3182-91. 1999
    ....
  6. pmc Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array
    J D Simeral
    Rehabilitation R and D Service, Department of Veterans Affairs Medical Center, Providence, RI 02912, USA
    J Neural Eng 8:025027. 2011
    ..Critical questions include how long implanted microelectrodes will record useful neural signals, how reliably those signals can be acquired and decoded, and how ..
  7. ncbi In-cell recordings by extracellular microelectrodes
    Aviad Hai
    Department of Neurobiology, Life Science Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    Nat Methods 7:200-2. 2010
    ..Here we report an approach to induce Aplysia californica neurons to actively engulf protruding microelectrodes, providing 'in-cell recordings' of subthreshold synaptic and action potentials with signal-to-noise ratio ..
  8. ncbi Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks
    Jaap van Pelt
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Neurons and Networks Research Group, 1105 AZ Amsterdam, The Netherlands
    IEEE Trans Biomed Eng 51:2051-62. 2004
    ....
  9. ncbi Real-time cell electrophysiology using a multi-channel dielectrophoretic-dot microelectrode array
    Henry O Fatoyinbo
    Centre for Biomedical Engineering, School of Engineering, University of Surrey, Guildford, UK
    Electrophoresis 32:2541-9. 2011
    ..application of up to eight alternating current electrical signals to independently addressable dot microelectrodes in an array format, allowing a DEP spectrum to be measured in 20 s, with a total cycle time between ..
  10. ncbi Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mov Disord 21:S259-83. 2006
    ..The increase in surgical risk of intracranial hemorrhage correlated to the number of microelectrode trajectories must be considered against the risk of suboptimal benefits related to omission of this technique...
  11. ncbi Continuous separation of colloidal particles using dielectrophoresis
    Nurul Amziah Md Yunus
    Department of Electrical and Electronic Engineering, Faculty of Engineering, Universiti Putra Malaysia, Selangor, Malaysia
    Electrophoresis 34:969-78. 2013
    ..The variation in device operation with applied signal voltage is presented and discussed in terms of separation efficiency, demonstrating 99.9% separation of a mixture of colloidal latex spheres...
  12. ncbi Improved measurements of Na+ fluxes in plants using calixarene-based microelectrodes
    Maheswari Jayakannan
    School of Earth and Environment, The University of Western Australia, M087, Crawley, WA 6009, Perth, Australia
    J Plant Physiol 168:1045-51. 2011
    Ion-selective microelectrodes are a powerful tool in studying adaptive responses of plant cells and tissues to various abiotic stresses...
  13. ncbi Dielectrophoretic concentration and separation of live and dead bacteria in an array of insulators
    Blanca H Lapizco-Encinas
    Microfluidics Department, Sandia National Laboratories, PO Box 969, MS 9951, Livermore, California 94551, USA
    Anal Chem 76:1571-9. 2004
    ..2-microm carboxylate-modified polystyrene particles. This first application of iDEP for simultaneous live/dead bacteria separation and concentration illustrates its potential as a front-end method for bacterial analysis...
  14. ncbi Rapid-on-chip determination of dielectric properties of biological cells using imaging techniques in a dielectrophoresis dot microsystem
    Henry O Fatoyinbo
    Centre for Biomedical Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, UK
    Electrophoresis 29:3-10. 2008
    ..This allows the automated acquisition of a spectrum of 26 data points in approximately 15 min...
  15. pmc Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH
    S Broer
    Physiologisch chemisches Institut der Universität, Hoppe Seyler Strasse 4, D 72076 Tubingen, Federal Republic of
    Biochem J 333:167-74. 1998
    ..investigated in monocarboxylate transporter 1 (MCT1)-expressing Xenopus laevis oocytes by using pH-sensitive microelectrodes and [14C]lactate...
  16. pmc Which elements of the mammalian central nervous system are excited by low current stimulation with microelectrodes?
    F Rattay
    Institute for Analysis and Scientific Computing, Vienna University of Technology, Wiedner Hauptstrasse 8 10, A 1040 Vienna, Austria
    Neuroscience 170:399-407. 2010
    ..Beside these exceptions, spike initiation site for cathodic low current stimulation appears rather close to the electrode...
  17. ncbi Microelectrode arrays for electrochemistry: approaches to fabrication
    Xing Jiu Huang
    Department of Chemistry, Physical and Theoretical Chemistry Laboratory Oxford University, South Parks Road Oxford OX1 3QZ, UK
    Small 5:776-88. 2009
    ..Techniques for the fabrication of such arrays are reviewed. The relative features and merits of different techniques are also discussed...
  18. pmc Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
    Jeremy J Clark
    Department of Psychiatry and Behavioral Sciences and Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Nat Methods 7:126-9. 2010
    ..Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice...
  19. ncbi Active sensing of target location encoded by cortical microstimulation
    Subramaniam Venkatraman
    Qualcomm Corporate R and D, San Diego, CA 92121, USA
    IEEE Trans Neural Syst Rehabil Eng 19:317-24. 2011
    ..This ability to deliver sensory percepts using cortical microstimulation in an active sensing system might have significant implications for the development of sensorimotor neuroprostheses...
  20. ncbi Development of microelectrode arrays for artificial retinal implants using liquid crystal polymers
    Seung Woo Lee
    School of Electrical Engineering and Computer Science, Seoul National University College of Medicine, Gwanak Gu, Korea
    Invest Ophthalmol Vis Sci 50:5859-66. 2009
    ..To develop a liquid crystal polymer (LCP)-based, long-term implantable, retinal stimulation microelectrode array using a novel fabrication method...
  21. ncbi Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony
    A Moran
    Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Brain 131:3395-409. 2008
    ..These findings indicate that the two neuronal populations are the outcome of very different oscillatory drives deriving from different local functional neuronal organizations...
  22. ncbi A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays
    Pratik Y Chhatbar
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, 450 Clarkson Av, Box 31, Brooklyn, NY 11203, USA
    J Neurosci Methods 188:187-94. 2010
    ..The ultimate result is a longer survival time with superior neural recordings that can potentially last longer than with traditional implantation techniques...
  23. ncbi Massively parallel recording of unit and local field potentials with silicon-based electrodes
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurophysiol 90:1314-23. 2003
    ..Silicon technology is a promising approach for high-density, high-resolution sampling of neuronal activity in both basic research and prosthetic devices...
  24. ncbi Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials
    Joseph F Rizzo
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 44:5362-9. 2003
    ..The primary goal was to assess the concordance of the form of induced perception and the pattern of electrical stimulation of the retina, and the reproducibility of the responses...
  25. pmc Dielectrophoretic manipulation of cells with spiral electrodes
    X B Wang
    Department of Experimental Pathology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Biophys J 72:1887-99. 1997
    ..Applications of spiral electrode arrays, including the isolation of cells of clinical relevance, are discussed...
  26. ncbi Early postnatal development of spontaneous and acoustically evoked discharge activity of principal cells of the medial nucleus of the trapezoid body: an in vivo study in mice
    Mandy Sonntag
    Faculty of Bioscience, Pharmacy, and Psychology, University of Leipzig, Leipzig, Germany
    J Neurosci 29:9510-20. 2009
    ..These data emphasize that models of signal transmission at the calyx of Held based on in vitro data have to take developmental changes in firing rates and response latencies up to the fourth postnatal week into account...
  27. ncbi Pattern motion selectivity of spiking outputs and local field potentials in macaque visual cortex
    Farhan A Khawaja
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 29:13702-9. 2009
    ..Together, these results suggest a surprisingly strong link between the sensory tuning of cortical LFPs and afferent inputs, with important implications for the interpretation of imaging studies and for models of cortical function...
  28. pmc Microseizures and the spatiotemporal scales of human partial epilepsy
    Matt Stead
    Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55901, USA
    Brain 133:2789-97. 2010
    ..epilepsy, wide-bandwidth electrophysiological recordings were obtained using clinical macro- and research microelectrodes in patients with epilepsy and control subjects with intractable facial pain...
  29. ncbi Temporally precise cortical firing patterns are associated with distinct action segments
    Tomer Shmiel
    Gonda Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurophysiol 96:2645-52. 2006
    ..Single-unit activity was recorded from eight microelectrodes inserted into the motor and premotor cortices of two monkeys while they were performing continuous ..
  30. pmc Low-density neuronal networks cultured using patterned poly-l-lysine on microelectrode arrays
    Sang Beom Jun
    Nano Bioelectronics and Systems Research Center, Seoul, Republic of Korea
    J Neurosci Methods 160:317-26. 2007
    ..Application of DNQX, an AMPA antagonist, blocked all spontaneous activity, suggesting that the activity is excitatory and mediated through glutamate receptors...
  31. ncbi Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex
    Selim Suner
    Department of Emergency Medicine and Surgery, Brown University, Providence, RI 02912, USA
    IEEE Trans Neural Syst Rehabil Eng 13:524-41. 2005
    ..Here, we demonstrate the reliability of a regular array of 100 microelectrodes to obtain neural recordings from primary motor cortex (MI) of monkeys for at least three months and up to 1...
  32. ncbi Neuronal avalanches are diverse and precise activity patterns that are stable for many hours in cortical slice cultures
    John M Beggs
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:5216-29. 2004
    ....
  33. ncbi Electrical forces for microscale cell manipulation
    Joel Voldman
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 8:425-54. 2006
    ..We first examine the forces and electrodes used to create them, then address potential impacts on cell health, followed by examples of devices for both separating cells and handling them...
  34. pmc Plasticity of recurring spatiotemporal activity patterns in cortical networks
    Radhika Madhavan
    Laboratory for Neuroengineering, Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA
    Phys Biol 4:181-93. 2007
    ....
  35. ncbi Electrical multisite stimulation of the isolated chicken retina
    A Stett
    NMI Natural and Medical Sciences Institute, Markwiesenstrasse 55, D 72770, Reutlingen, Germany
    Vision Res 40:1785-95. 2000
    ..The response was altered or disappeared when synaptic transmission was blocked. Our results indicate that shape perception and object location can be partially achieved with subretinal electrical multisite stimulation...
  36. pmc Role of electrode design on the volume of tissue activated during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Neural Eng 3:1-8. 2006
    ..Therefore, it may be possible to improve therapeutic benefit and minimize side effects from DBS with the design of target-specific electrodes...
  37. ncbi Local generation of fast ripples in epileptic brain
    Anatol Bragin
    Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurosci 22:2012-21. 2002
    ..Our data illustrate that hypothesized clusters of highly interconnected neurons are capable of overcoming interneuron feedback inhibition, resulting in generation of epileptiform bursts, eventually leading to seizure activity...
  38. pmc Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces
    Takashi D Yoshida Kozai
    Neural Engineering Lab, Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Mater 11:1065-73. 2012
    Implantable neural microelectrodes that can record extracellular biopotentials from small, targeted groups of neurons are critical for neuroscience research and emerging clinical applications including brain-controlled prosthetic devices...
  39. ncbi Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials
    Sami Myllymaa
    Department of Physics, University of Kuopio, Kuopio, Finland
    Biosens Bioelectron 24:3067-72. 2009
    ..The present microelectrode array consists of eight platinum microelectrodes (round-shaped, Ø: 200 microm), transmission lines and connector pads sandwiched between two thin layers of ..
  40. ncbi Action potential recording from dielectrophoretically positioned neurons inside micro-wells of a planar microelectrode array
    Fadi T Jaber
    Centre for Biomedical Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom
    J Neurosci Methods 182:225-35. 2009
    ..Spontaneous and evoked action potentials from trapped neurons were successfully recorded using a 16-channel acquisition/stimulation unit...
  41. ncbi Electrical interfacing between neurons and electronics via vertically integrated sub-4 microm-diameter silicon probe arrays fabricated by vapor-liquid-solid growth
    Takeshi Kawano
    Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1 1 Tempaku cho, Toyohashi, Aichi 441 8580, Japan
    Biosens Bioelectron 25:1809-15. 2010
    ..In addition, the probe arrays can be integrated with microelectronics; therefore, these probes make it possible to construct interfaces between neurons and microelectronics in advanced neuroscience applications...
  42. ncbi Flame etching enhances the sensitivity of carbon-fiber microelectrodes
    Andrew M Strand
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904 4319, USA
    Anal Chem 80:3708-15. 2008
    ..In this paper, we compare two methods of fabrication of small, cylindrical carbon-fiber microelectrodes: flame-etching and electrochemical etching...
  43. ncbi Dielectrophoretic manipulation and separation of microparticles using curved microelectrodes
    Khashayar Khoshmanesh
    Centre for Intelligent Systems Research, Deakin University, Victoria, Australia
    Electrophoresis 30:3707-17. 2009
    ..The system is composed of arrays of microelectrodes integrated to a microchannel...
  44. ncbi A new approach to neural cell culture for long-term studies
    S M Potter
    156 29 Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Neurosci Methods 110:17-24. 2001
    ..Membrane-sealed dishes will also be useful for the culture of many other cell types susceptible to evaporation and contamination...
  45. pmc System-level biochip for impedance sensing and programmable manipulation of bladder cancer cells
    Cheng Hsin Chuang
    Department of Mechanical Engineering, Southern Taiwan University, Tainan 71005, Taiwan
    Sensors (Basel) 11:11021-35. 2011
    ....
  46. pmc Microsample preparation by dielectrophoresis: isolation of malaria
    Peter Gascoyne
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Lab Chip 2:70-5. 2002
    ..By simple adjustment of the electrical field parameters, other cell subpopulations that characterise disease, such as residual cancer cells in blood, can be similarly isolated and analysed...
  47. pmc Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes
    Christopher B Jacobs
    Dept of Chemistry, University of Virginia, P O Box 400319, Charlottesville, VA 22904, USA
    Analyst 136:3557-65. 2011
    ..In this study, we modified carbon-fiber microelectrodes (CFMEs) with three differently functionalized single-wall carbon nanotubes and measured their response to ..
  48. pmc Parallel recording of neurotransmitters release from chromaffin cells using a 10×10 CMOS IC potentiostat array with on-chip working electrodes
    Brian N Kim
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biosens Bioelectron 41:736-44. 2013
    ..We anticipate that this device will accelerate the characterization of the modulation of neurotransmitter secretion from neuronal and endocrine cells by pharmacological and molecular manipulations of the cells...
  49. ncbi Intraocular retinal prosthesis. Big steps to sight restoration
    James D Weiland
    Intraocular Retinal Prosthesis Laboratory, Keck School of Medicine, University of Southern California, USA
    IEEE Eng Med Biol Mag 25:60-6. 2006
  50. pmc Virtual active touch using randomly patterned intracortical microstimulation
    Joseph E O'Doherty
    Department of Physiology and the W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
    IEEE Trans Neural Syst Rehabil Eng 20:85-93. 2012
    ..These results add to the growing evidence that temporally patterned ICMS can be used to simulate a tactile sense for neuroprosthetic devices...
  51. pmc Nafion-CNT coated carbon-fiber microelectrodes for enhanced detection of adenosine
    Ashley E Ross
    Dept of Chemistry, University of Virginia, Charlottesville, VA 22904, USA
    Analyst 137:3045-51. 2012
    ..Adenosine can be monitored using fast-scan cyclic voltammetry at carbon-fiber microelectrodes and ATP is a possible interferent in vivo because the electroactive moiety, adenine, is the same for both ..
  52. ncbi Regulation of exocytosis in chromaffin cells by trans-insertion of lysophosphatidylcholine and arachidonic acid into the outer leaflet of the cell membrane
    Christian Amatore
    Ecole Normale Superieure, Departement de Chimie, UMR CNRS ENS UPMC 8640 PASTEUR, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Chembiochem 7:1998-2003. 2006
    ..We also observed that the detected amount of neurotransmitters in the presence of LPC was larger than under control conditions, while the opposite trend is observed with AA...
  53. pmc Ultramicroelectrode array based sensors: a promising analytical tool for environmental monitoring
    Jahir Orozco
    Instituto de Microelectronica de Barcelona, IMB CNM CSIC, Campus UAB, 08193 Bellaterra, Barcelona, Spain
    Sensors (Basel) 10:475-90. 2010
    ..A brief explanation of theoretical aspects that highlight their electrochemical behavior is also given. Finally, the applications of this transducer platform in the environmental field are discussed...
  54. ncbi Dielectrophoresis of lambda-DNA using 3D carbon electrodes
    Rodrigo Martínez-Duarte
    Laboratory of Microsystems, Ecole Polytechnique Federale de Lausanne, Switzerland
    Electrophoresis 34:1113-22. 2013
    ....
  55. pmc Parallel input channels to mouse primary visual cortex
    Enquan Gao
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:5912-26. 2010
    ..These correlations suggest that neurons in mouse V1 receive inputs from a weighted combination of parallel afferent pathways with distinct spatiotemporal sensitivities...
  56. ncbi Microelectronic packaging for retinal prostheses
    Damien C Rodger
    California Institute of Technology, Pasadena, CA 91125, USA
    IEEE Eng Med Biol Mag 24:52-7. 2005
  57. ncbi Somatosensory discrimination based on cortical microstimulation
    R Romo
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico DF
    Nature 392:387-90. 1998
    ..b>Microelectrodes were inserted into area 3b of S1 and the second stimulus was substituted with a train of injected current ..
  58. ncbi The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes
    Kelsey A Potter
    Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Jr Drive, Wickenden Bldg, Cleveland, OH 44106, USA
    Biomaterials 34:7001-15. 2013
    ..Specifically, adult rats implanted within intracortical microelectrodes were systemically administered the anti-oxidant, resveratrol, both the day before and the day of surgery...
  59. ncbi Simulations of electrode placement for a thalamic visual prosthesis
    John S Pezaris
    Neurosurgery Department, Massachusetts General Hospital, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 56:172-8. 2009
    ..For idealized microwire electrodes, spacing as large as 600 microm in three dimensions would allow for over 250 phosphenes per visual hemifield in macaques, and over 800 in humans...
  60. ncbi Ultrafast detection and quantification of brain signaling molecules with carbon fiber microelectrodes
    Rinchen D Lama
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    Anal Chem 84:8096-101. 2012
    Carbon fiber microelectrodes provide the ideal platform for performing ultrafast, selective measurements of electroactive brain molecules...
  61. pmc Carbon microelectrodes with a renewable surface
    Pavel Takmakov
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Anal Chem 82:2020-8. 2010
    ..We also demonstrate that application of the extended waveform could restore the sensitivity of carbon microelectrodes diminished by irreversible adsorption (electrode fouling) of byproducts resulting from the electrooxidation ..
  62. ncbi Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes
    Kenji Yoshimi
    Department of Neurophysiology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Res 71:49-62. 2011
    ..In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine...
  63. ncbi Optimisation of a microfluidic analysis chamber for the placement of microelectrodes
    Michelle Rogers
    Department of Bioengineering, Imperial College, London, UK SW7 2AZ
    Phys Chem Chem Phys 13:5298-303. 2011
    ..The coalescence chamber creates a constant aqueous environment ideal for the placement of microelectrodes avoiding the contamination of the microelectrode surface by oil...
  64. ncbi Integrated wireless neural interface based on the Utah electrode array
    S Kim
    Department of Electrical and Computer Engineering, University of Utah, 50 South Central Campus Drive, Salt Lake City, UT 84112, USA
    Biomed Microdevices 11:453-66. 2009
    ..The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package...
  65. ncbi Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco 94143, USA
    J Neurosurg 104:488-501. 2006
    ....
  66. ncbi The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics
    Ian L Jones
    Department Biosystems Science and Engineering, Eidgenossische Technische Hochschule Zurich, Basel, Switzerland
    Anal Bioanal Chem 399:2313-29. 2011
    ....
  67. ncbi Parylene flexible neural probes integrated with microfluidic channels
    Shoji Takeuchi
    Center for International Research on MicroMechatronics, Institute of Industrial Science, Tokyo, Japan
    Lab Chip 5:519-23. 2005
    ..We were able to insert the probe into a rat's brain and measure the neural signals with the electrode...
  68. ncbi Community structure, abundance, and in situ activity of nitrifying bacteria in river sediments as determined by the combined use of molecular techniques and microelectrodes
    Yoshiyuki Nakamura
    Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, North 13, West 8, Sapporo 060 8628, Japan
    Environ Sci Technol 40:1532-9. 2006
    ..use of 16S rRNA gene-cloning analysis, real-time quantitative polymerase chain reaction (RTQ-PCR) assays, and microelectrodes. The goal of this research was to evaluate the contribution of nitrifying activity in the sediment to the ..
  69. ncbi High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays
    Jiangang Du
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    J Neurophysiol 101:1671-8. 2009
    ..The large-scale integration of such dual-side and multilayer arrays is expected to provide massively parallel recording capabilities in the brain...
  70. ncbi Spatiotemporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording
    Penphimon Phongphanphanee
    Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Neurosci 28:9309-18. 2008
    ..The present study revealed an extensive excitatory network in the dSC that may contribute to the generation of activity by a large population of neurons that discharge before a saccade...
  71. pmc Predicting visual sensitivity in retinal prosthesis patients
    Alan Horsager
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:1483-91. 2009
    ....
  72. ncbi Cortical microstimulation in auditory cortex of rat elicits best-frequency dependent behaviors
    Kevin J Otto
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
    J Neural Eng 2:42-51. 2005
    ..however, the perceptual effects of auditory cortical microstimulation delivered through penetrating microelectrodes have not been clearly elucidated...
  73. ncbi Stepwise pattern modification of neuronal network in photo-thermally-etched agarose architecture on multi-electrode array chip for individual-cell-based electrophysiological measurement
    Ikurou Suzuki
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro, Tokyo 153 8902, Japan
    Lab Chip 5:241-7. 2005
    ..We can thus better understand the meaning of neuronal network patterns and connection directions...
  74. ncbi Microelectrodes for the measurement of catecholamines in biological systems
    P S Cahill
    Department of Chemistry, University of North Carolina, Chapel Hill 27599 3290, USA
    Anal Chem 68:3180-6. 1996
    ..For the study of neurotransmitter release in vivo, larger cylindrical microelectrodes are advantageous because the secreted molecules come from multiple terminals near the electrode, and the ..
  75. pmc Factors affecting perceptual thresholds in epiretinal prostheses
    Chloé de Balthasar
    Department of Ophthalmology and Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 49:2303-14. 2008
    ..S. Food and Drug Administration (FDA)-approved clinical trial...
  76. ncbi Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays
    Alexandra Gramowski
    Institute of Cell Biology and Biosystems Technology, University of Rostock, Albert Einstein Strasse 3, 18059 Rostock, Germany
    Eur J Neurosci 19:2815-25. 2004
    ..It is anticipated that this kind of approach will help to quantify pharmacological responses of networks used as biosensors...
  77. ncbi Single-cell trapping utilizing negative dielectrophoretic quadrupole and microwell electrodes
    Ling Sheng Jang
    Department of Electrical Engineering and Center for Micro Nano Science and Technology, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
    Biosens Bioelectron 24:3637-44. 2009
    ..Manipulation of particle motion using ACET-induced fluid flow to the target trap is modeled numerically and is in good agreement with the experimental results...
  78. ncbi Polytrodes: high-density silicon electrode arrays for large-scale multiunit recording
    Timothy J Blanche
    Department of Ophthalmology and Visual Sciences, University of British Columbia, 2550 Willow St, Vancouver, BC V5Z 3N9, Canada
    J Neurophysiol 93:2987-3000. 2005
    ..It was possible to maintain stable recordings from active neurons adjacent to the polytrode without change in their absolute positions, neurophysiological or receptive field properties...
  79. pmc Microphysiology of epileptiform activity in human neocortex
    Catherine A Schevon
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Neurophysiol 25:321-30. 2008
    ..The authors hypothesize that microdischarges and microseizures are generated by small cortical domains that form the substrate of epileptogenic cortex and play important roles in seizure initiation and propagation...
  80. ncbi Intracellular features predicted by extracellular recordings in the hippocampus in vivo
    D A Henze
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurophysiol 84:390-400. 2000
    ..This theoretical maximum is in contrast to the approximately six units that are usually detected per tetrode. From this, we conclude that a large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition...
  81. pmc Neuronal loss due to prolonged controlled-current stimulation with chronically implanted microelectrodes in the cat cerebral cortex
    Douglas McCreery
    Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    J Neural Eng 7:036005. 2010
    Activated iridium microelectrodes were implanted for 450-1282 days in the sensorimotor cortex of seven adult domestic cats and then pulsed for 240 h (8 h per day for 30 days) at 50 Hz...
  82. ncbi Recording spikes from a large fraction of the ganglion cells in a retinal patch
    Ronen Segev
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Neurosci 7:1154-61. 2004
    ..Using these methods, we show that about 60 receptive fields of ganglion cells cover each point in visual space in the salamander, consistent with anatomical findings...
  83. ncbi Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuities
    Klas H Pettersen
    Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As
    J Neurosci Methods 154:116-33. 2006
    ..To illustrate the application to real data, iCSD estimates of stimulus-evoked responses measured with laminar electrodes in the rat somatosensory (barrel) cortex are compared to estimates from the standard CSD method...
  84. ncbi An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats
    Takakuni Goto
    Tohoku University, Institute of Development, Aging and Cancer, Sendai 980 8575, Japan
    J Neurophysiol 104:3388-412. 2010
    ..We concluded that the conductivity profile must be included in future developments of CSD analysis, especially for rodents...
  85. pmc Relationships among low-frequency local field potentials, spiking activity, and three-dimensional reach and grasp kinematics in primary motor and ventral premotor cortices
    Arjun K Bansal
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    J Neurophysiol 105:1603-19. 2011
    ....
  86. ncbi Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity
    Michael L A V Heien
    Department of Chemistry and Neuroscience Center, Chapel Hill, NC 27599, USA
    Analyst 128:1413-9. 2003
    The voltammetric responses of carbon-fiber microelectrodes with a 1.0 V and a 1.4 V anodic limit were compared in this study. Fast-scan cyclic voltammetry was used to characterize the response to dopamine and several other neurochemicals...
  87. ncbi Optoelectronic retinal prosthesis: system design and performance
    J D Loudin
    Hansen Experimental Physics Laboratory, Stanford University, 445 Via Palou, Stanford, CA 94305, USA
    J Neural Eng 4:S72-84. 2007
    ..Pixel sizes are scalable from 100 to 25 microm, corresponding to 640-10,000 pixels on an implant 3 mm in diameter...
  88. pmc Brain penetration effects of microelectrodes and DBS leads in STN or GPi
    J M Mann
    Department of Neurology, University of Florida College of Medicine Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurol Neurosurg Psychiatry 80:794-7. 2009
    ..Secondarily, to evaluate whether the longevity of the MER and lead placement effects were influenced by target location (subthalamic nucleus (STN) or globus pallidus interna (GPi))...
  89. ncbi Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
    ....
  90. ncbi Model-based analysis of cortical recording with silicon microelectrodes
    Michael A Moffitt
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, ND 20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Neurophysiol 116:2240-50. 2005
    The purpose of this study was to use computational modeling to better understand factors that impact neural recordings with silicon microelectrodes used in brain-machine interfaces.
  91. ncbi Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures
    Marcel Halbach
    Institut fur Neurophysiologie, Universitat zu Koln
    Cell Physiol Biochem 13:271-84. 2003
    ..Therefore in this study we aim to characterize intrinsic action potential (AP) parameters by simultaneous recording of APs and FPs...
  92. ncbi Single-unit neural recording with active microelectrode arrays
    Q Bai
    Engineering Research Laboratory, Agilent Technologies, Inc, Palo Alto, CA 94304-1126, USA
    IEEE Trans Biomed Eng 48:911-20. 2001
    ..The multiplexed system adds less than 8-muV rms of noise to the recorded signals, suppressing the 5-V clock transitions to less than 2 ppm...
  93. ncbi Gelatine-embedded electrodes--a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes
    Gustav Lind
    Department of Experimental Medical Sciences, Neuronano Research Center, Lund University, BMC F10, Lund, Sweden
    J Neural Eng 7:046005. 2010
    ..Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion...
  94. ncbi Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
    ..Using multiple microelectrodes, preferably in a concentric parallel array allows a precise mapping of the STN region...
  95. ncbi Long-term, multisite, parallel, in-cell recording and stimulation by an array of extracellular microelectrodes
    Aviad Hai
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurophysiol 104:559-68. 2010
    ..development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMmicroEs) that practically provide intracellular recordings and stimulation of many individual neurons, ..
  96. ncbi Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferences from the measurement of L-glutamate and other analytes
    J J Burmeister
    Department of Anatomy, Center for Sensor Technology, University of Kentucky, Lexington 40536-0098, USA
    Anal Chem 73:1037-42. 2001
    A self-referencing technique utilizing two microelectrodes on a ceramic-based multisite array is employed for confirmation and elimination of interferences detected by enzyme-based microelectrodes...
  97. ncbi Responses of rat subicular neurons to convergent stimulation of lateral entorhinal cortex and CA1 in vivo
    J Gigg
    Department of Psychology, University of Dublin, Trinity College, 2, Dublin, Ireland
    Brain Res 884:35-50. 2000
    ..These data support the existence of a reciprocal excitatory connection between lateral entorhinal cortex and dorsal subiculum and suggest further that this connection may involve only bursting subicular neurons...
  98. ncbi Cortical innervation of the facial nucleus in the non-human primate: a new interpretation of the effects of stroke and related subtotal brain trauma on the muscles of facial expression
    R J Morecraft
    Division of Basic Biomedical Sciences, The University of South Dakota School of Medicine, Vermillion, South Dakota, USA
    Brain 124:176-208. 2001
    ....
  99. ncbi Thresholds for activation of rabbit retinal ganglion cells with an ultrafine, extracellular microelectrode
    Ralph J Jensen
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:3533-43. 2003
    ..To determine electrical thresholds required for extracellular activation of retinal ganglion cells as part of a project to develop an epiretinal prosthesis...
  100. ncbi Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease
    Philip V Theodosopoulos
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Mov Disord 18:791-8. 2003
    ..Our findings are consistent with the small number of published studies on STN somatopy in the human and the nonhuman primate...
  101. ncbi Electrical stimulation of mammalian retinal ganglion cells with multielectrode arrays
    Chris Sekirnjak
    The Salk Institute for Biological Studies, San Diego, California, USA
    J Neurophysiol 95:3311-27. 2006
    ..We review previous epiretinal stimulation studies and discuss our results in the context of 32 other publications, comparing threshold parameters and safety limits...

Research Grants69

  1. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..While extracellular O2 is readily measured with microelectrodes, to fully characterize functional hyperemia, a method to measure CBF is required. 2...
  2. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..a portable stimulator to map the trajectory of the peroneal nerve to determine the point of insertion of the microelectrodes;both devices must be small, portable and battery powered. 5...
  3. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2012
    ..recording technologies are being developed and commercialized for chronic human use: 1) small intracortical microelectrodes that are implanted a few millimeters into the brain and can detect the firing activity of many individual ..
  4. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..Functional electrical stimulation in the central nervous system with penetrating microelectrodes has potential applications in clinical medicine and basic neural science, and high-rate stimulation can ..
  5. Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
    Greg M Swain; Fiscal Year: 2010
    Electrochemical methods with diamond microelectrodes will be used to investigate neuronal signaling pathways in the gut wall...
  6. Geobiological approaches to understanding pulmonary infections in situ
    Dianne K Newman; Fiscal Year: 2013
    ..We will employ state- of-the-art microelectrodes to characterize the chemical environment of the host lung at micrometer length scales, looking for chemical ..
  7. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2013
    ..objectives, and in which ionic and nitric oxide fluxes will be measured in real time using selective microelectrodes. We will focus on two epithelia, the epididymis, which is at the core of our research program, and the ..
  8. Novel modalities for assessing the cortical tissue-electrode interface
    Jeffrey R Capadona; Fiscal Year: 2010
    ..Further, chemical modifications to traditional penetrating intracortical microelectrodes will also be explored, with the focus of promoting biomaterial-mediated gene transfer of the new virus to ..
  9. A MICRO-ELECTRODE STUDY OF OXYGEN-BASED FUNCTIONAL CONNECTIVITY
    Lawrence H Snyder; Fiscal Year: 2012
    ..Guided by resting state fMRI scans, we will insert multiple platinum microelectrodes into a macaque brain in order to verify and characterize correlated fluctuations in oxygen concentration...
  10. Regulation of conducted hyperpolarization in microvascular endothelial cell tubes
    ERIK JOSEF BEHRINGER; Fiscal Year: 2012
    ..My experimental design uses two sharp (intracellular) microelectrodes to simultaneously inject current (+/- 0...
  11. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    CHRISTINA ROSE MARMAROU; Fiscal Year: 2012
    ..We will utilize sodium and potassium ion selective microelectrodes to measure the ionic changes in the extracellular space which play a major role in determining the amount of ..
  12. Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes
    STEVEN SCOTT SAAVEDRA; Fiscal Year: 2013
    ..Carbon fiber microelectrodes have been widely used in these studies to enable rapid, highly sensitive, and label-free measurement of ..
  13. The Goldman Chip: A bioMEMS Platform for Integrating Patch Clamp with Ion-Selecti
    David Marshall Porterfield; Fiscal Year: 2011
    ..are now needed for High Throughput Screening (HTS) for ion channel modifiers, and the proposed work seeks to advance this area by using a bioMEMS approach to integrate patch-clamp electrophysiology with ion-specific microelectrodes.
  14. The Goldman Chip: A bioMEMS Platform for Integrating Patch Clamp with Ion-Selecti
    Jenna L Rickus; Fiscal Year: 2012
    ..for High Throughput Screening (HTS) for ion channel modifiers, and the proposed work seeks to advance this area by using a bioMEMS approach to integrate patch-clamp electrophysiology with ion-specific microelectrodes.
  15. Ion transport and motility in larval mosquito stomach
    David F Moffett; Fiscal Year: 2010
    ..across isolated stomach segments and its regulation, using conventional transepithelial techniques and microelectrodes 2...
  16. Mechanisms Mediating Age-Related Impairments in Microvascular Collaterals
    STEVEN JEFFREY MILLER; Fiscal Year: 2012
    ..NO in young and old rats will be measured under conditions of acute and chronic increases in flow with microelectrodes. Antioxidants and NO cofactors and substrates will be used to determine the pathways involved in regulation ..
  17. SECRETION FROM INDIVIDUAL VESICLES
    ROBERT MARK WIGHTMAN; Fiscal Year: 2012
    ..To evaluate events after exocytosis, carbon-fiber microelectrodes can be placed in tissue slices maintained in physiological buffer...
  18. Linking Spatial Variations in Shear Stress with Oxidation Stress
    Tzung K Hsiai; Fiscal Year: 2013
    ..EIS;specifically, the frequency-dependent electrical and dielectrical properties between concentric bipolar microelectrodes and endoluminal surface of explants of human arteries and NZW rabbit aortas...
  19. Spatiotemporal Distribution of Oxygen in Biofilm Infections
    Philip S Stewart; Fiscal Year: 2013
    ..in parallel with experimental measurements of oxygen distributions in novel in vitro biofilm models using microelectrodes and 19F magnetic resonance imaging oximetry...
  20. Ultrananocrystalline Diamond Microarray Biosensor for Neurochemical Detection
    Prabhu U Arumugam; Fiscal Year: 2012
    ..9 billion in 2012. Based on a letter of support from a leading neurophysiological microelectrodes and instrumentation company, the expected annual sales for this product at FHC Inc...
  21. Thalamic Visual Prosthesis
    John S Pezaris; Fiscal Year: 2013
    ..This device has microelectrodes placed in the lateral geniculate nucleus of the thalamus, part of the brain that relays signals from the eye ..
  22. Label-free HIV-1 Viral Load Measurement through a Contactless Electrode Microchip
    Hadi Shafiee; Fiscal Year: 2013
    ..virus complexes will be then introduced into the microfluidic device with the optimized contactless microelectrodes functionalized with gp120 antibody to capture the nanobead-HIV complex...
  23. Functional Invitro CNS and PNS Myelination Model
    Stephen Lambert; Fiscal Year: 2013
    ..will be provided not only by myotube contraction, but also by stimulating and recording microelectrodes flanking the myelination compartment, that allow for direct measurements of conduction velocity changes ..
  24. NIH SBIR Phase I: Development of a Novel Boron-doped Ultrananocrystalline Diamond
    Prabhu U Arumugam; Fiscal Year: 2011
    ..cyclic voltammetry and potassium ferrocyanide solution and (iii) to demonstrate the unique advantages of UNCD microelectrodes by measuring dopamine with flow injection analysis and in the anesthetized rat brain...
  25. PERIPHERAL MECHANISMS OF HEARING
    Mario A Ruggero; Fiscal Year: 2013
    ..The electrical responses of individual auditory-nerve fibers are recorded with fine-tipped microelectrodes. Cochlear vibrations will be measured at both apical and basal regions, which principally encode low- and ..
  26. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..Both are electroactive and amenable to detection with fast-scan cyclic voltammetry at carbon-fiber microelectrodes. Three specific aims focus on new technology (1, 3, and 5), to be evaluated in anesthetized rats, and two ..
  27. Effects of Cochlear Lesions on Thalamocortical Rhythms-Relationship to Tinnitus
    Daniel Stolzberg; Fiscal Year: 2012
    ..The experiments will be performed in rats chronically implanted with thalamic and cortical microelectrodes. To accomplish this, recordings will be made from the auditory portion of the thalamus and cortex in awake-..
  28. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    JEROME NONE ENGEL; Fiscal Year: 2013
    ..Consequently, we first propose to carry out long-term video-EEG monitoring with multiple microelectrodes to characterize the spatial and temporal patterns of epileptogenesis in this TBI model, and interictal ..
  29. Microchip devices to assay quantal exocytosis
    KEVIN GILLIS; Fiscal Year: 2009
    ..The specific aims are: 1) Develop approaches to automatically target individual cells to electrochemical microelectrodes on microfabricated devices...
  30. Combining optogenetics and electrophysiology to dissect accumbens microcircuits
    Joshua D Berke; Fiscal Year: 2012
    ..These cells will be monitored using microelectrodes, and distinguished via their response to brief pulses of laser light...
  31. CD14 facilitates neural device integration and performance
    Jeffrey R Capadona; Fiscal Year: 2013
    ..Therefore, we hypothesize that CD14 inhibition will enable intracortical microelectrodes to more consistently record high quality neural units...
  32. DYNAMICS OF IN VIVO DOPAMINE RELEASE
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..We will use fast-scan cyclic voltammetry at carbon-fiber microelectrodes for measurements of catecholamine release from neurons...
  33. New Electroanalytical Methods for Single-Cell Exocytosis
    Bo Zhang; Fiscal Year: 2013
    ..We propose to address these challenges by developing new electroanalytical techniques and microelectrodes. We emphasize the use of a nanoband electrode integrated with on-chip microelectrodes to increase accuracy ..
  34. Development of a Microfluidic Thermal Regulator for Studies of Cortical Function
    LEAH ANN KRUBITZER; Fiscal Year: 2013
    ..This device, or "cooling chip", includes indwelling microthermocouples and recording microelectrodes to monitor temperature and neural response and make online adjustments of cooling parameters to reach a ..
  35. Quantitation of Simultaneous Hydrogen Peroxide and Dopamine Dynamics In Vivo
    Leslie A Sombers; Fiscal Year: 2013
    ..Carbon-fiber microelectrodes will be employed with fast-scan cyclic voltammetry, as this approach provides a quantitative view of ..
  36. NEUROSCIENCE TRAINING PROGRAM
    DANIEL T TRANEL; Fiscal Year: 2013
    ..to cells to integrated functional systems) and diversity of approaches (from ion channels and patch clamp microelectrodes to transgenic and gene-knockout mouse models to human lesion-deficit and functional neuroimaging to ..
  37. Neural Probe for high spatial and temporal resolution detection of cocaine and su
    BRIAN GLENN JAMIESON; Fiscal Year: 2013
    ..every second over a relatively large spatial area (500 [unreadable]m length electrode), and carbon-fiber microelectrodes to detect dopamine with fast scan cyclic voltammetry (FSCV)...
  38. Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
    Mesut Sahin; Fiscal Year: 2012
    ..Movement of the tissue around these rigid microelectrodes causes significant shear forces due to the mechanical mismatch between the electrode material and the neural ..
  39. Characterization of Cholinergic Modulation of Dopamine Neurotransmission
    Leslie A Sombers; Fiscal Year: 2010
    ..experiments (that are not dependent on one another) using fast-scan cyclic voltammetry (FSCV) at carbon fiber microelectrodes. This electrochemical approach is well suited for real-time measurements of chemical changes in the brain, ..
  40. Multi-plexed Cardiac Biomarker Detection Using Electrochemically Active Aptamers
    THOMAS W OWEN; Fiscal Year: 2010
    ..risk for such life- threatening conditions, ISL's Phase I efforts will focus on the characterization of microelectrodes modified with a trimolecular SAM and the ability of the modified electrodes to provide ultrasensitive ..
  41. Functions of Associative Auditory Cortical Plasticity
    Norman M Weinberger; Fiscal Year: 2013
    ..To test these hypotheses and reveal mnemonic functions of associative plasticity we will train rats with microelectrodes chronically implanted in their primary auditory cortex (A1), to bar-press for water in the presence of a tone...
  42. The Role of the Locus Coeruleus Norepinephrine System in Response Inhibition
    MATTHEW DAVID RIEDY; Fiscal Year: 2012
    ..Rats will be implanted with microelectrodes in LC for recording and stimulation...
  43. Nicotinic regulation of cortical ACh release and behavioral function
    MARTIN F SARTER; Fiscal Year: 2010
    ..Preliminary studies utilized enzyme-selective microelectrodes to monitor ACh and glutamate release at a high temporal resolution...
  44. Methods for Measuring Sub-second Neurotransmitter Interactions
    Michael A Johnson; Fiscal Year: 2013
    ..Although one technique, fast-scan cyclic voltammetry at carbon-fiber microelectrodes, offers sufficient temporal resolution to measure the release and uptake of electroactive biogenic amines ..
  45. CCK CELL FUNCTION
    Rodger A Liddle; Fiscal Year: 2010
    ..be measured using patch clamp recording techniques and membrane potential will be measured with conventional microelectrodes. The following specific aims will be addressed: 1...
  46. ESOPHAGEAL CYTOPROTECTION--AGENTS AND MECHANISMS
    Roy Orlando; Fiscal Year: 2009
    ..into EE, and for those identified, to localize the site of action to ACMs and/or ICJs and characterize, by pH-microelectrodes, the ability to lower pHi...
  47. Neural probe for high spatial and temporal resolution detection of cocaine and GA
    BRIAN GLENN JAMIESON; Fiscal Year: 2013
    ..every second over a relatively large spatial area (500[unreadable]m length electrode), and carbon-fiber microelectrodes to detect dopamine with fast scan cyclic voltammetry (FSCV)...
  48. Development and Evaluation of Biodegradable Neural Probes
    Martin Han; Fiscal Year: 2009
    ..to develop novel biodegradable probe materials for enhancing recording and stimulation capabilities of microelectrodes used in neural prostheses and neuroscience...
  49. Study Exocytosis in the Region of Synaptic Cleft using Electrochemical Nanoprobe
    Mei Shen; Fiscal Year: 2013
    ..progress has been made in understanding exocytosis via electrochemical studies of neurotransmitters via microelectrodes. However, current techniques are limited to a spatial resolution of approximately a micron, making it ..
  50. Microfabricated Neural Probe for the Rapid Detection of Multiple Neurochemicals I
    BRIAN GLENN JAMIESON; Fiscal Year: 2013
    ..every second over a relatively large spatial area (500[unreadable]m length electrode), and carbon-fiber microelectrodes to detect dopamine with fast scan cyclic voltammetry (FSCV)...
  51. Structural/functional interaction between RyR1 and DHPR alpha1s and Beta1a isofor
    Claudio F Perez; Fiscal Year: 2012
    ..myotubes (nulls for RyRs, DHPRs and RyR/DHPR) and tested using calcium imaging, patch-clamp and calcium microelectrodes. Relevance: A full understanding of the elaborate signaling processes that take place during skeletal muscle ..
  52. Functional Neural Connectivity During Social Bonding in Voles
    Robert C Liu; Fiscal Year: 2013
    ..Our use of implanted microelectrodes in awake animals will enable new questions and hypotheses about the mechanisms of social (or even nonsocial) ..
  53. Revolutionizing Utah Array using Nanotechnology to Enhance Efficacy and Longevity
    Patrick A Tresco; Fiscal Year: 2013
    ..we present a novel surface modification technique that addresses the longevity and efficacy of the microelectrodes in chronic experiments...
  54. Cortical reorganization and behavioral recovery after sensory loss
    Hui Xin Qi; Fiscal Year: 2013
    ..Functional magnetic resonance imaging (fMRI), acute recordings with single microelectrodes or multi-electrode arrays, sensory-motor behavioral measures and anatomical procedures will be used to ..
  55. Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea
    Mark Parker; Fiscal Year: 2013
    ..Specific Aim 1B is to use Xenopus oocytes, with ion-selective microelectrodes, to determine whether SLC4A11 cotransports Na+ and HCO3-...
  56. Development of a prototype system for assaying exocytosis from individual cells
    XIN ALICE LIU; Fiscal Year: 2012
    ..that the prototype device can acquire data ~10-fold faster than the current method using carbon-fiber microelectrodes, and thus will establish that radical improvements in throughput can be achieved in a practical platform...
  57. VAPOR GROWN CARBON FIBERS FOR BIOMEDICAL APPLICATIONS
    THOMAS APPLE; Fiscal Year: 1993
    ..which hold great promise for application in reinforced composite materials for prosthetic devices and as microelectrodes for monitoring cell processes...
  58. WINCS and DBS
    Kendall H Lee; Fiscal Year: 2013
    ..FSCV) for real-time simultaneous in vivo monitoring of dopamine and adenosine release at carbon-fiber microelectrodes as well as fixed potential amperometry for monitoring of glutamate at enzyme-linked biosensors...
  59. PAH Bioremediation and Monitoring in Biowalls
    Paul Bishop; Fiscal Year: 2009
    ..component will focus on design and evaluation of mulch-based biowalls and development of pollutant monitoring microelectrodes for application in studying the biodegradation of PAH-metal mixtures in water aquifers at Superfund sites...
  60. Improved neuroelectrode characteristics using nanomaterials
    Edward Keefer; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Plexon Inc will coat the active sites of metal microelectrodes with carbon nanotubes and carbon nanotube/conductive polymer composite materials...
  61. Novel Bioactive Coatings for Chronically Implanted MEMS based Moveable Microelect
    Arati Sridharan; Fiscal Year: 2013
    ..by incorporating anti-inflammatory biochemicals in various polymer-matrices as coatings surrounding the microelectrodes. The primary focus has been to suppress inflammation via biochemical release...
  62. Neuroprosthesis development utilizing afferent neural activity recorded with non-
    TIMOTHY M BRUNS; Fiscal Year: 2012
    ..decode limb position with high accuracy from recordings of primary afferent neural activity with penetrating microelectrodes inserted in lumbar DRG, and has applied these signals as feedback within closed-loop FES control of the lower ..
  63. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
    ..rate of oxygen exit from arterioles by diffusion a phenomenon measured by other investigators using oxygen microelectrodes and the change in microvessel blood oxygen saturation and by us using the phosphorescence quenching technique...
  64. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..The proposal addresses the RFA's invitation to "develop microelectrodes that can simultaneously stimulate and record and perform microdialysis or infuse chemicals"...
  65. CENTER FOR CNS INJURY STUDIES
    Mitchell Chesler; Fiscal Year: 2000
    ..Using on-selective microelectrodes, voltage clamp, and spectrophotometric methods, we will test the hypothesis that voltage-dependent Na:HCO3 co-..
  66. ACUPUNTURE AND HYPERTENSION: EFFICACY AND MECHANISMS
    Norman Kaplan; Fiscal Year: 2000
    ..The ability to record SNA with microelectrodes in conscious humans provides a new opportunity to test this novel mechanistic hypothesis in patients ..
  67. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2009
    ..nervous system diseases require implantation of electrically conductive interfaces between neural tissues and microelectrodes. Currently available metal/silicon-based devices are not stable over the long term, mostly due to gliosis and ..
  68. SIC-COATED ELECTRODES FOR NEURAL PROSTHESES
    Stuart Cogan; Fiscal Year: 2000
    The development of SiC-coated microelectrodes for neural stimulation and recording is proposed. The microelectrodes will employ thin-films of amorphous silicon carbide (a-SiC) as dielectric insulation on iridium shafts...
  69. PROXIMAL COLON--A DISTINCT TRANSPORT EPITHELIUM
    Joseph Sellin; Fiscal Year: 1993
    ..Through a variety of techniques (Ussing chamber, microelectrodes, patch clamp) we will characterize the macroscopic and microscopic features of cecal Na absorption that ..