microelectrodes

Summary

Summary: Electrodes with an extremely small tip, used in a voltage clamp or other apparatus to stimulate or record bioelectric potentials of single cells intracellularly or extracellularly. (Dorland, 28th ed)

Top Publications

  1. ncbi Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
    R D Braun
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 280:H2533-44. 2001
  2. ncbi Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes
    M J Shattock
    Division of Biomedical Sciences, University of California, Riverside 92521 0121
    Am J Physiol 256:C813-22. 1989
  3. pmc Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation
    Mark H Histed
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 63:508-22. 2009
  4. doi In-cell recordings by extracellular microelectrodes
    Aviad Hai
    Department of Neurobiology, Life Science Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    Nat Methods 7:200-2. 2010
  5. doi Development of microelectrode arrays for artificial retinal implants using liquid crystal polymers
    Seung Woo Lee
    School of Electrical Engineering and Computer Science, Seoul National University College of Medicine, Gwanak Gu, Korea
    Invest Ophthalmol Vis Sci 50:5859-66. 2009
  6. doi Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony
    A Moran
    Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Brain 131:3395-409. 2008
  7. doi Active sensing of target location encoded by cortical microstimulation
    Subramaniam Venkatraman
    Qualcomm Corporate R and D, San Diego, CA 92121, USA
    IEEE Trans Neural Syst Rehabil Eng 19:317-24. 2011
  8. ncbi Model-based analysis of cortical recording with silicon microelectrodes
    Michael A Moffitt
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, ND 20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Neurophysiol 116:2240-50. 2005
  9. doi A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays
    Pratik Y Chhatbar
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, 450 Clarkson Av, Box 31, Brooklyn, NY 11203, USA
    J Neurosci Methods 188:187-94. 2010
  10. ncbi Massively parallel recording of unit and local field potentials with silicon-based electrodes
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurophysiol 90:1314-23. 2003

Detail Information

Publications280 found, 100 shown here

  1. ncbi Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
    R D Braun
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 280:H2533-44. 2001
    In this study we compare oxygen tension (PO2) histograms measured with O2 microelectrodes and a new optical PO2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) (n = 5-6)...
  2. ncbi Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes
    M J Shattock
    Division of Biomedical Sciences, University of California, Riverside 92521 0121
    Am J Physiol 256:C813-22. 1989
    ..movements in rabbit and rat ventricular muscle were compared using extracellular double-barreled Ca-selective microelectrodes. In rabbit ventricle, steady-state twitches were associated with transient extracellular Ca (Cao) depletions, ..
  3. pmc Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation
    Mark H Histed
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 63:508-22. 2009
    ..Our results indicate that the pattern of activated neurons likely arises from the direct activation of axons in a volume tens of microns in diameter...
  4. doi In-cell recordings by extracellular microelectrodes
    Aviad Hai
    Department of Neurobiology, Life Science Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    Nat Methods 7:200-2. 2010
    ..Here we report an approach to induce Aplysia californica neurons to actively engulf protruding microelectrodes, providing 'in-cell recordings' of subthreshold synaptic and action potentials with signal-to-noise ratio ..
  5. doi Development of microelectrode arrays for artificial retinal implants using liquid crystal polymers
    Seung Woo Lee
    School of Electrical Engineering and Computer Science, Seoul National University College of Medicine, Gwanak Gu, Korea
    Invest Ophthalmol Vis Sci 50:5859-66. 2009
    ..To develop a liquid crystal polymer (LCP)-based, long-term implantable, retinal stimulation microelectrode array using a novel fabrication method...
  6. doi Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony
    A Moran
    Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Brain 131:3395-409. 2008
    ..These findings indicate that the two neuronal populations are the outcome of very different oscillatory drives deriving from different local functional neuronal organizations...
  7. doi Active sensing of target location encoded by cortical microstimulation
    Subramaniam Venkatraman
    Qualcomm Corporate R and D, San Diego, CA 92121, USA
    IEEE Trans Neural Syst Rehabil Eng 19:317-24. 2011
    ..This ability to deliver sensory percepts using cortical microstimulation in an active sensing system might have significant implications for the development of sensorimotor neuroprostheses...
  8. ncbi Model-based analysis of cortical recording with silicon microelectrodes
    Michael A Moffitt
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Lerner Research Institute, ND 20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Neurophysiol 116:2240-50. 2005
    The purpose of this study was to use computational modeling to better understand factors that impact neural recordings with silicon microelectrodes used in brain-machine interfaces.
  9. doi A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays
    Pratik Y Chhatbar
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, 450 Clarkson Av, Box 31, Brooklyn, NY 11203, USA
    J Neurosci Methods 188:187-94. 2010
    ..The ultimate result is a longer survival time with superior neural recordings that can potentially last longer than with traditional implantation techniques...
  10. ncbi Massively parallel recording of unit and local field potentials with silicon-based electrodes
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurophysiol 90:1314-23. 2003
    ..Silicon technology is a promising approach for high-density, high-resolution sampling of neuronal activity in both basic research and prosthetic devices...
  11. pmc Microseizures and the spatiotemporal scales of human partial epilepsy
    Matt Stead
    Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55901, USA
    Brain 133:2789-97. 2010
    ..epilepsy, wide-bandwidth electrophysiological recordings were obtained using clinical macro- and research microelectrodes in patients with epilepsy and control subjects with intractable facial pain...
  12. ncbi Temporally precise cortical firing patterns are associated with distinct action segments
    Tomer Shmiel
    Gonda Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurophysiol 96:2645-52. 2006
    ..Single-unit activity was recorded from eight microelectrodes inserted into the motor and premotor cortices of two monkeys while they were performing continuous ..
  13. ncbi Human anterior cingulate cortex neurons encode cognitive and emotional demands
    Karen D Davis
    Toronto Western Research Institute, University of Toronto, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 25:8402-6. 2005
    ....
  14. pmc In situ analysis of nitrifying biofilms as determined by in situ hybridization and the use of microelectrodes
    S Okabe
    Department of Urban and Environmental Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060 0813, Japan
    Appl Environ Microbiol 65:3182-91. 1999
    ....
  15. ncbi Polytrodes: high-density silicon electrode arrays for large-scale multiunit recording
    Timothy J Blanche
    Department of Ophthalmology and Visual Sciences, University of British Columbia, 2550 Willow St, Vancouver, BC V5Z 3N9, Canada
    J Neurophysiol 93:2987-3000. 2005
    ..It was possible to maintain stable recordings from active neurons adjacent to the polytrode without change in their absolute positions, neurophysiological or receptive field properties...
  16. pmc Low-density neuronal networks cultured using patterned poly-l-lysine on microelectrode arrays
    Sang Beom Jun
    Nano Bioelectronics and Systems Research Center, Seoul, Republic of Korea
    J Neurosci Methods 160:317-26. 2007
    ..Application of DNQX, an AMPA antagonist, blocked all spontaneous activity, suggesting that the activity is excitatory and mediated through glutamate receptors...
  17. ncbi Neuronal avalanches are diverse and precise activity patterns that are stable for many hours in cortical slice cultures
    John M Beggs
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:5216-29. 2004
    ....
  18. ncbi Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex
    Selim Suner
    Department of Emergency Medicine and Surgery, Brown University, Providence, RI 02912, USA
    IEEE Trans Neural Syst Rehabil Eng 13:524-41. 2005
    ..Here, we demonstrate the reliability of a regular array of 100 microelectrodes to obtain neural recordings from primary motor cortex (MI) of monkeys for at least three months and up to 1...
  19. ncbi Electrical multisite stimulation of the isolated chicken retina
    A Stett
    NMI Natural and Medical Sciences Institute, Markwiesenstrasse 55, D 72770, Reutlingen, Germany
    Vision Res 40:1785-95. 2000
    ..The response was altered or disappeared when synaptic transmission was blocked. Our results indicate that shape perception and object location can be partially achieved with subretinal electrical multisite stimulation...
  20. pmc Plasticity of recurring spatiotemporal activity patterns in cortical networks
    Radhika Madhavan
    Laboratory for Neuroengineering, Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA
    Phys Biol 4:181-93. 2007
    ....
  21. pmc Role of electrode design on the volume of tissue activated during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Neural Eng 3:1-8. 2006
    ..Therefore, it may be possible to improve therapeutic benefit and minimize side effects from DBS with the design of target-specific electrodes...
  22. ncbi Local generation of fast ripples in epileptic brain
    Anatol Bragin
    Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurosci 22:2012-21. 2002
    ..Our data illustrate that hypothesized clusters of highly interconnected neurons are capable of overcoming interneuron feedback inhibition, resulting in generation of epileptiform bursts, eventually leading to seizure activity...
  23. doi Ultrafast detection and quantification of brain signaling molecules with carbon fiber microelectrodes
    Rinchen D Lama
    Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
    Anal Chem 84:8096-101. 2012
    Carbon fiber microelectrodes provide the ideal platform for performing ultrafast, selective measurements of electroactive brain molecules...
  24. doi Improved measurements of Na+ fluxes in plants using calixarene-based microelectrodes
    Maheswari Jayakannan
    School of Earth and Environment, The University of Western Australia, M087, Crawley, WA 6009, Perth, Australia
    J Plant Physiol 168:1045-51. 2011
    Ion-selective microelectrodes are a powerful tool in studying adaptive responses of plant cells and tissues to various abiotic stresses...
  25. pmc Carbon microelectrodes with a renewable surface
    Pavel Takmakov
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Anal Chem 82:2020-8. 2010
    ..We also demonstrate that application of the extended waveform could restore the sensitivity of carbon microelectrodes diminished by irreversible adsorption (electrode fouling) of byproducts resulting from the electrooxidation ..
  26. doi Integrated wireless neural interface based on the Utah electrode array
    S Kim
    Department of Electrical and Computer Engineering, University of Utah, 50 South Central Campus Drive, Salt Lake City, UT 84112, USA
    Biomed Microdevices 11:453-66. 2009
    ..The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package...
  27. pmc Brain penetration effects of microelectrodes and DBS leads in STN or GPi
    J M Mann
    Department of Neurology, University of Florida College of Medicine Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida 32610, USA
    J Neurol Neurosurg Psychiatry 80:794-7. 2009
    ..Secondarily, to evaluate whether the longevity of the MER and lead placement effects were influenced by target location (subthalamic nucleus (STN) or globus pallidus interna (GPi))...
  28. doi Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes
    Kenji Yoshimi
    Department of Neurophysiology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Neurosci Res 71:49-62. 2011
    ..In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine...
  29. doi Optimisation of a microfluidic analysis chamber for the placement of microelectrodes
    Michelle Rogers
    Department of Bioengineering, Imperial College, London, UK SW7 2AZ
    Phys Chem Chem Phys 13:5298-303. 2011
    ..The coalescence chamber creates a constant aqueous environment ideal for the placement of microelectrodes avoiding the contamination of the microelectrode surface by oil...
  30. ncbi Parylene flexible neural probes integrated with microfluidic channels
    Shoji Takeuchi
    Center for International Research on MicroMechatronics, Institute of Industrial Science, Tokyo, Japan
    Lab Chip 5:519-23. 2005
    ..We were able to insert the probe into a rat's brain and measure the neural signals with the electrode...
  31. doi Spatiotemporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording
    Penphimon Phongphanphanee
    Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8585, Japan
    J Neurosci 28:9309-18. 2008
    ..The present study revealed an extensive excitatory network in the dSC that may contribute to the generation of activity by a large population of neurons that discharge before a saccade...
  32. doi High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays
    Jiangang Du
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    J Neurophysiol 101:1671-8. 2009
    ..The large-scale integration of such dual-side and multilayer arrays is expected to provide massively parallel recording capabilities in the brain...
  33. ncbi Community structure, abundance, and in situ activity of nitrifying bacteria in river sediments as determined by the combined use of molecular techniques and microelectrodes
    Yoshiyuki Nakamura
    Department of Urban and Environmental Engineering, Graduate School of Engineering, Hokkaido University, North 13, West 8, Sapporo 060 8628, Japan
    Environ Sci Technol 40:1532-9. 2006
    ..use of 16S rRNA gene-cloning analysis, real-time quantitative polymerase chain reaction (RTQ-PCR) assays, and microelectrodes. The goal of this research was to evaluate the contribution of nitrifying activity in the sediment to the ..
  34. doi The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics
    Ian L Jones
    Department Biosystems Science and Engineering, Eidgenossische Technische Hochschule Zurich, Basel, Switzerland
    Anal Bioanal Chem 399:2313-29. 2011
    ....
  35. ncbi Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco 94143, USA
    J Neurosurg 104:488-501. 2006
    ....
  36. ncbi Stepwise pattern modification of neuronal network in photo-thermally-etched agarose architecture on multi-electrode array chip for individual-cell-based electrophysiological measurement
    Ikurou Suzuki
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro, Tokyo 153 8902, Japan
    Lab Chip 5:241-7. 2005
    ..We can thus better understand the meaning of neuronal network patterns and connection directions...
  37. pmc Predicting visual sensitivity in retinal prosthesis patients
    Alan Horsager
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 50:1483-91. 2009
    ....
  38. ncbi Microelectrodes for the measurement of catecholamines in biological systems
    P S Cahill
    Department of Chemistry, University of North Carolina, Chapel Hill 27599 3290, USA
    Anal Chem 68:3180-6. 1996
    ..For the study of neurotransmitter release in vivo, larger cylindrical microelectrodes are advantageous because the secreted molecules come from multiple terminals near the electrode, and the ..
  39. ncbi Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays
    Alexandra Gramowski
    Institute of Cell Biology and Biosystems Technology, University of Rostock, Albert Einstein Strasse 3, 18059 Rostock, Germany
    Eur J Neurosci 19:2815-25. 2004
    ..It is anticipated that this kind of approach will help to quantify pharmacological responses of networks used as biosensors...
  40. ncbi Cortical microstimulation in auditory cortex of rat elicits best-frequency dependent behaviors
    Kevin J Otto
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
    J Neural Eng 2:42-51. 2005
    ..however, the perceptual effects of auditory cortical microstimulation delivered through penetrating microelectrodes have not been clearly elucidated...
  41. pmc Factors affecting perceptual thresholds in epiretinal prostheses
    Chloé de Balthasar
    Department of Ophthalmology and Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 49:2303-14. 2008
    ..S. Food and Drug Administration (FDA)-approved clinical trial...
  42. ncbi Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuities
    Klas H Pettersen
    Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As
    J Neurosci Methods 154:116-33. 2006
    ..To illustrate the application to real data, iCSD estimates of stimulus-evoked responses measured with laminar electrodes in the rat somatosensory (barrel) cortex are compared to estimates from the standard CSD method...
  43. pmc Parallel input channels to mouse primary visual cortex
    Enquan Gao
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:5912-26. 2010
    ..These correlations suggest that neurons in mouse V1 receive inputs from a weighted combination of parallel afferent pathways with distinct spatiotemporal sensitivities...
  44. doi Gelatine-embedded electrodes--a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes
    Gustav Lind
    Department of Experimental Medical Sciences, Neuronano Research Center, Lund University, BMC F10, Lund, Sweden
    J Neural Eng 7:046005. 2010
    ..Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion...
  45. ncbi Single-unit neural recording with active microelectrode arrays
    Q Bai
    Engineering Research Laboratory, Agilent Technologies, Inc, Palo Alto, CA 94304-1126, USA
    IEEE Trans Biomed Eng 48:911-20. 2001
    ..The multiplexed system adds less than 8-muV rms of noise to the recorded signals, suppressing the 5-V clock transitions to less than 2 ppm...
  46. ncbi Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferences from the measurement of L-glutamate and other analytes
    J J Burmeister
    Department of Anatomy, Center for Sensor Technology, University of Kentucky, Lexington 40536-0098, USA
    Anal Chem 73:1037-42. 2001
    A self-referencing technique utilizing two microelectrodes on a ceramic-based multisite array is employed for confirmation and elimination of interferences detected by enzyme-based microelectrodes...
  47. ncbi Responses of rat subicular neurons to convergent stimulation of lateral entorhinal cortex and CA1 in vivo
    J Gigg
    Department of Psychology, University of Dublin, Trinity College, 2, Dublin, Ireland
    Brain Res 884:35-50. 2000
    ..These data support the existence of a reciprocal excitatory connection between lateral entorhinal cortex and dorsal subiculum and suggest further that this connection may involve only bursting subicular neurons...
  48. ncbi Intracellular features predicted by extracellular recordings in the hippocampus in vivo
    D A Henze
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurophysiol 84:390-400. 2000
    ..This theoretical maximum is in contrast to the approximately six units that are usually detected per tetrode. From this, we conclude that a large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition...
  49. ncbi Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
    ..Using multiple microelectrodes, preferably in a concentric parallel array allows a precise mapping of the STN region...
  50. doi Long-term, multisite, parallel, in-cell recording and stimulation by an array of extracellular microelectrodes
    Aviad Hai
    The Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurophysiol 104:559-68. 2010
    ..development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMmicroEs) that practically provide intracellular recordings and stimulation of many individual neurons, ..
  51. ncbi Somatosensory discrimination based on cortical microstimulation
    R Romo
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico DF
    Nature 392:387-90. 1998
    ..b>Microelectrodes were inserted into area 3b of S1 and the second stimulus was substituted with a train of injected current ..
  52. ncbi Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease
    Philip V Theodosopoulos
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Mov Disord 18:791-8. 2003
    ..Our findings are consistent with the small number of published studies on STN somatopy in the human and the nonhuman primate...
  53. ncbi Thresholds for activation of rabbit retinal ganglion cells with an ultrafine, extracellular microelectrode
    Ralph J Jensen
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:3533-43. 2003
    ..To determine electrical thresholds required for extracellular activation of retinal ganglion cells as part of a project to develop an epiretinal prosthesis...
  54. ncbi Electrical stimulation of mammalian retinal ganglion cells with multielectrode arrays
    Chris Sekirnjak
    The Salk Institute for Biological Studies, San Diego, California, USA
    J Neurophysiol 95:3311-27. 2006
    ..We review previous epiretinal stimulation studies and discuss our results in the context of 32 other publications, comparing threshold parameters and safety limits...
  55. ncbi Cortical innervation of the facial nucleus in the non-human primate: a new interpretation of the effects of stroke and related subtotal brain trauma on the muscles of facial expression
    R J Morecraft
    Division of Basic Biomedical Sciences, The University of South Dakota School of Medicine, Vermillion, South Dakota, USA
    Brain 124:176-208. 2001
    ....
  56. pmc An in vitro model of a retinal prosthesis
    Ashish K Ahuja
    Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089 2654, USA
    IEEE Trans Biomed Eng 55:1744-53. 2008
    ..66 +/- 1.30 nC/cm2, respectively, while the required charge was 12.5 +/- 6.2 and 19 +/- 3.3 nC...
  57. ncbi Networks of neurons coupled to microelectrode arrays: a neuronal sensory system for pharmacological applications
    M Chiappalone
    Department of Biophysical and Electronic Engineering DIBE, Neuroengineering and Bio nano Technologies Group, University of Genova, Genova, Italy
    Biosens Bioelectron 18:627-34. 2003
    ....
  58. pmc An array of microactuated microelectrodes for monitoring single-neuronal activity in rodents
    Jit Muthuswamy
    Harrington Department of Bioengineering, ECG 334, P O Box 879709, Arizona State University, Tempe, AZ 85287 9709, USA
    IEEE Trans Biomed Eng 52:1470-7. 2005
    Arrays of microelectrodes used for monitoring single- and multi-neuronal action potentials often fail to record from the same population of neurons over a period of time for several technical and biological reasons...
  59. doi Microelectrodes with gold nanoparticles and self-assembled monolayers for in vivo recording of striatal dopamine
    Tien Chun Tsai
    Department of Biomedical Engineering, National Cheng Kung University, No 1, Ta Hsueh Road, Tainan 701, Taiwan
    Analyst 137:2813-20. 2012
    Electrochemical determination of in vivo dopamine (DA) using implantable microelectrodes is essential for monitoring the DA depletion of an animal model of Parkinson's disease (PD), but faces substantial interference from ascorbic acid (..
  60. doi An in vitro characterisation comparing carbon paste and Pt microelectrodes for real-time detection of brain tissue oxygen
    Fiachra B Bolger
    Department of Chemistry, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    Analyst 136:4028-35. 2011
    In vitro characterisation results for O(2) reduction at Pt-based microelectrodes are presented and compared with those for carbon-paste electrodes (CPEs). Cyclic voltammetry indicates a potential of -650 mV vs...
  61. ncbi Intersection of microwire electrodes with proximal CA1 stratum-pyramidale neurons at insertion for multiunit recordings predicted by a 3-D computer model
    Enric Claverol-Tinture
    Department of Electronics, Technical University of Catalonia, Jordi Girona, 1 3, 08034 Barcelona, Spain
    IEEE Trans Biomed Eng 51:2211-6. 2004
    ..e., an insertion normal to the cell body layer)...
  62. pmc Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining
    Patrick T McCarthy
    School of Mechanical Engineering, Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907, USA
    Biomed Microdevices 13:503-15. 2011
    ..by the intrinsic brittleness of silicon, the material most commonly used for manufacture of penetrating microelectrodes. This brittleness creates predisposition for catastrophic fracture, which may adversely affect the ..
  63. doi Monopolar vs. bipolar subretinal stimulation-an in vitro study
    Matthias Gerhardt
    Tyndall National Institute, Prospect Row, Cork, Ireland
    J Neurosci Methods 199:26-34. 2011
    ..Liquid inclusions, eventually separating the retina from the electrodes are discussed to be a major cause for low ganglion cell responses during stimulation with the bipolar electrode configuration...
  64. ncbi Diamond microelectrodes for in vitro electroanalytical measurements: current status and remaining challenges
    JinWoo Park
    Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA
    Analyst 133:17-24. 2008
    ..research field in electrochemistry today is the preparation, characterization and application of diamond microelectrodes for electroanalytical measurements in biological media...
  65. doi Carbon nanotube composite coating of neural microelectrodes preferentially improves the multiunit signal-to-noise ratio
    Gytis Baranauskas
    Robotics, Brain and Cognitive Sciences Department, Italian Institute of Technology, Genoa, Italy
    J Neural Eng 8:066013. 2011
    Extracellular metal microelectrodes are widely used to record single neuron activity in vivo. However, their signal-to-noise ratio (SNR) is often far from optimal due to their high impedance value...
  66. doi Independent positioning of microelectrodes for multisite recordings in vitro
    Klaus Albus
    Institut fur Neurophysiologie, Johannes Müller Centre of Physiology, CCM, Charite Universitatsmedizin Berlin, Tucholskystr 2, D 10117 Berlin, Germany
    J Neurosci Methods 176:182-5. 2009
    ..handle, inexpensive multisite recording system is described which allows independent positioning of several microelectrodes with high precision axial movement of each electrode...
  67. pmc Carbon-fiber microelectrodes modified with 4-sulfobenzene have increased sensitivity and selectivity for catecholamines
    Andre Hermans
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    Langmuir 22:1964-9. 2006
    Elliptical and cylindrical geometries of carbon-fiber microelectrodes were modified by covalent attachment of 4-sulfobenzenediazonium tetrafluoroborate following its electroreduction...
  68. doi Catch and release cell sorting: electrochemical desorption of T-cells from antibody-modified microelectrodes
    He Zhu
    Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Street 2619, Davis, CA 95616, United States
    Colloids Surf B Biointerfaces 64:260-8. 2008
    ..microsystem for selective capture and release of cells consisted of an array of individually addressable gold microelectrodes fabricated on a glass substrate...
  69. pmc "Black" responses dominate macaque primary visual cortex v1
    Chun I Yeh
    Center for Neural Science, New York University, New York, 10036, USA
    J Neurosci 29:11753-60. 2009
    ..1988, 1995; Olman et al., 2008)...
  70. doi Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface
    Yi Lu
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China
    Biomaterials 30:4143-51. 2009
    ..in the electrochemical impedance and maximum charge injection (Q(inj)) limits of the coated iridium oxide microelectrodes were negligible. Protein adsorption on PDMS was reduced by approximately 85% after coating...
  71. ncbi Carbon fiber microelectrodes with multiple sensing elements for in vivo voltammetry
    Shawn F Dressman
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurosci Methods 119:75-81. 2002
    ..The microelectrodes were used to monitor extracellular dopamine at multiple depths beneath the brain surface during electrical ..
  72. ncbi Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes
    Stephane Arbault
    Departement de Chimie, UMR CNRS 8640 PASTEUR, Ecole Normale Superieure, 24 rue Lhomond, F 75231 Paris Cedex 05, France
    Carcinogenesis 25:509-15. 2004
    ..They were investigated here at the level of a single fibroblast by an electrochemical method based on microelectrodes we have developed previously...
  73. doi Temperature dependence and interferences of NO and N₂O microelectrodes used in wastewater treatment
    Sarina Jenni
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:2257-66. 2012
    ..The results from this study help to significantly shorten and optimize the determination of the correction functions and are therefore relevant for all users of nitric and nitrous oxide electrodes...
  74. doi Reducing surface area while maintaining implant penetrating profile lowers the brain foreign body response to chronically implanted planar silicon microelectrode arrays
    John L Skousen
    Department of Bioengineering, University of Utah, Salt Lake City, UT, USA
    Prog Brain Res 194:167-80. 2011
    ....
  75. doi Nanostructured gold microelectrodes for extracellular recording from electrogenic cells
    D Bruggemann
    Institute of Complex Systems and Peter Grünberg Institute Bioelectronics ICS8 PGI8, Forschungszentrum Julich GmbH, Julich, Germany
    Nanotechnology 22:265104. 2011
    ..Increasing the aspect ratio of the gold nanopillars and changing the geometrical layout can further enhance the signal quality in the future...
  76. doi Functional groups modulate the sensitivity and electron transfer kinetics of neurochemicals at carbon nanotube modified microelectrodes
    Christopher B Jacobs
    Dept of Chemistry, University of Virginia, P O Box 400319, Charlottesville, VA 22904, USA
    Analyst 136:3557-65. 2011
    ..In this study, we modified carbon-fiber microelectrodes (CFMEs) with three differently functionalized single-wall carbon nanotubes and measured their response to ..
  77. doi Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions
    Fredrik Johansson
    Nano Neuro Research Center, Lund University, Sweden
    Acta Biomater 5:2230-7. 2009
    ..We conclude that a pSi surface, due to its large surface area, diminished inflammatory response and firm adhesion to the tissue, should be a good material for the development of new implantable electronic nerve devices...
  78. pmc Corrosion of tungsten microelectrodes used in neural recording applications
    Erin Patrick
    Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
    J Neurosci Methods 198:158-71. 2011
    ..The reduced in vivo corrosion rate as compared to the bench-top rate is attributed to decreased rate of oxygen diffusion caused by the presence of a biological film and a reduced concentration of available oxygen in the brain...
  79. ncbi Thin microelectrodes reduce GFAP expression in the implant site in rodent somatosensory cortex
    Paula Stice
    Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287 9709, USA
    J Neural Eng 4:42-53. 2007
    ..Future studies with longer implant durations can confirm if this observation remains consistent beyond 4 weeks...
  80. ncbi Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes
    N L Nakhoul
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 274:C543-8. 1998
    ..We expressed AQP1 in Xenopus oocytes by injecting AQP1 cRNA, and we assessed CO2 permeability by using microelectrodes to monitor the changes in intracellular pH (pHi) produced by adding 1...
  81. doi A comparative study on fabrication techniques for on-chip microelectrodes
    Yuksel Temiz
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Life Sciences Electronics CLSE, EPFL STI IBI CLSE Station 17, Lausanne, Switzerland
    Lab Chip 12:4920-8. 2012
    ..Pt microelectrodes with diameters of 50 μm, 100 μm and 200 μm are patterned on a Si substrate with SiO(2) film...
  82. doi Flame etching enhances the sensitivity of carbon-fiber microelectrodes
    Andrew M Strand
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904 4319, USA
    Anal Chem 80:3708-15. 2008
    ..In this paper, we compare two methods of fabrication of small, cylindrical carbon-fiber microelectrodes: flame-etching and electrochemical etching...
  83. ncbi Real-time refinement of subthalamic nucleus targeting using Bayesian decision-making on the root mean square measure
    Anan Moran
    Gonda Multidisciplinary Brain Research Center and Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Mov Disord 21:1425-31. 2006
    ....
  84. doi Integration of single-cell trapping and impedance measurement utilizing microwell electrodes
    Kung Chieh Lan
    Department of Electrical Engineering and Center for Micro Nano Science and Technology, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan
    Biosens Bioelectron 26:2025-31. 2011
    ..The results show that the impedance error of the particle is about 3%. Finally, the developed structure is applied to trap and measure the impedance of a HeLa cell...
  85. ncbi Investigation of parameters controlling the dielectrophoretic assembly of carbon nanotubes on microelectrodes
    Maria Dimaki
    MIC Department of Micro and Nanotechnology, Technical University of Denmark, Bldg 345E, 2800 Kgs Lyngby, Denmark
    J Nanosci Nanotechnol 8:1973-8. 2008
    Networks of single-walled carbon nanotubes were assembled onto microelectrodes by dielectrophoresis...
  86. ncbi A carbon fiber microelectrode-based third-generation biosensor for superoxide anion
    Yang Tian
    Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8502, Japan
    Biosens Bioelectron 21:557-64. 2005
    ..Along with the implantable capacity inherent in the CFMEs, these striking analytical properties of the CFME-based biosensors substantially make them potential for in vivo determination of O(2)(-)...
  87. pmc Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses
    Spencer S Kellis
    Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah, USA
    Neurosurg Focus 27:E9. 2009
    ..The goal of this study was to determine whether a nonpenetrating, high-density microwire array could provide sufficient information to serve as the interface for decoding motor cortical signals...
  88. doi Specific oxygen-containing functional groups on the carbon surface underlie an enhanced sensitivity to dopamine at electrochemically pretreated carbon fiber microelectrodes
    James G Roberts
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
    Langmuir 26:9116-22. 2010
    The in vivo use of carbon-fiber microelectrodes for neurochemical investigation has proven to be selective and sensitive when coupled with background-subtracted fast-scan cyclic voltammetry (FSCV)...
  89. ncbi Optimized carbon nanotube fiber microelectrodes as potential analytical tools
    Lucie Viry
    Centre de Recherche Paul Pascal, CNRS, 115 Av A Schweiter, 33600 Pessac, France
    Anal Bioanal Chem 389:499-505. 2007
    The preparation and interesting electrochemical properties of carbon nanotube (CNT) fiber microelectrodes are reported...
  90. doi Selective trapping of live and dead mammalian cells using insulator-based dielectrophoresis within open-top microstructures
    Chun Ping Jen
    Department of Mechanical Engineering, National Chung Cheng University, No 168, University Rd, Min Hsiung, Chia Yi, 62102, Taiwan, Reublic of China
    Biomed Microdevices 11:597-607. 2009
    ..For retaining the merit of microfabrication, the microelectrodes were deposited on the substrate to reduce the voltage required, due to the shortened spacing between them...
  91. pmc Micro-field evoked potentials recorded from the porcine sub-dural cortical surface utilizing a microelectrode array
    Joseph P Kitzmiller
    Department of Neurology, The Ohio State University, Means Hall 469, 1654 Upham Drive, Columbus, OH 43210, USA
    J Neurosci Methods 162:155-61. 2007
    ..Further work will be needed to determine how these micro-field potentials, which demonstrate selectivity for one eye, relate to the distribution of the ocular dominance columns of the occipital cortex...
  92. doi An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats
    Takakuni Goto
    Tohoku University, Institute of Development, Aging and Cancer, Sendai 980 8575, Japan
    J Neurophysiol 104:3388-412. 2010
    ..We concluded that the conductivity profile must be included in future developments of CSD analysis, especially for rodents...
  93. doi Interdigitated array microelectrodes based impedance biosensors for detection of bacterial cells
    Madhukar Varshney
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Biosens Bioelectron 24:2951-60. 2009
    ..Interdigitated array microelectrodes (IDAM) have been integrated with impedance detection in order to miniaturize the conventional electrodes, ..
  94. ncbi Optoelectronic retinal prosthesis: system design and performance
    J D Loudin
    Hansen Experimental Physics Laboratory, Stanford University, 445 Via Palou, Stanford, CA 94305, USA
    J Neural Eng 4:S72-84. 2007
    ..Pixel sizes are scalable from 100 to 25 microm, corresponding to 640-10,000 pixels on an implant 3 mm in diameter...
  95. ncbi Multielectrode microprobes for deep-brain stimulation fabricated with a customizable 3-D electroplating process
    Paulo S Motta
    Department of Electrical Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
    IEEE Trans Biomed Eng 52:923-33. 2005
    ..e., smoothly tapering diameter) with a corresponding mechanically stable shank...
  96. ncbi Magnetic field perturbation of neural recording and stimulating microelectrodes
    Francisco M Martinez-Santiesteban
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Phys Med Biol 52:2073-88. 2007
    ..However, little attention has been paid to the image artefacts produced by the microelectrodes that compromise the anatomical or functional information of those studies...
  97. pmc Visual prosthesis
    Peter H Schiller
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Perception 37:1529-59. 2008
    ....
  98. ncbi Impedance-based retinal contact imaging as an aid for the placement of high resolution epiretinal prostheses
    Lee Johnson
    SFA Inc, Onsite Contractor for the Naval Research Laboratory, 4555 Overlook Avenue, Washington, DC 20375, USA
    J Neural Eng 4:S17-23. 2007
    ..In addition, we evaluated the three-dimensional profile of the stimulation voltage distribution to assess the importance of close retinal contact for high resolution stimulation...
  99. ncbi Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances
    Matthew D Johnson
    Biomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109, USA
    IEEE Trans Neural Syst Rehabil Eng 13:160-5. 2005
    ..In most cases, these changes did parallel an improvement in SNR. These findings suggest that rejuvenation may be a useful intervention strategy to prolong the lifetime of chronically implanted microelectrodes.
  100. ncbi Neuronal network morphology and electrophysiologyof hippocampal neurons cultured on surface-treated multielectrode arrays
    Walid V Soussou
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    IEEE Trans Biomed Eng 54:1309-20. 2007
    ..These data indicate that factors, which influence adherence of neurons to surfaces, can profoundly impact both neuronal network morphology and electrophysiological activity in vitro...
  101. ncbi Fabrication of implantable microelectrode arrays by laser cutting of silicone rubber and platinum foil
    M Schuettler
    Department of Medical Physics and Bioengineering, University College London, Implanted Devices Group, Malet Place Engineering Building, Gower Street, London WC1E 6BT, UK
    J Neural Eng 2:S121-8. 2005
    ..The method does not require expensive clean room facilities and offers an extremely short design-to-prototype time of below 1 day. First prototypes demonstrate a minimal achievable feature size of about 30 microm...

Research Grants91

  1. Technology for an advanced cochlear nucleus auditory prosthesis
    Douglas McCreery; Fiscal Year: 2009
    ..In animal studies, penetrating microelectrodes are better able to convey the spectral information of sound, and NF2 patients whose auditory brainstem ..
  2. Technology for an advanced cochlear nucleus auditory prosthesis
    Douglas McCreery; Fiscal Year: 2009
    ..In animal studies, penetrating microelectrodes are better able to convey the spectral information of sound, and NF2 patients whose auditory brainstem ..
  3. Intra vs. extracortical command signals to restore six dimensional hand movements
    DAWN MARIE TAYLOR; Fiscal Year: 2010
    ..recording technologies are being developed and commercialized for chronic human use: 1) small intracortical microelectrodes that are implanted a few millimeters into the brain and can detect the firing activity of many individual ..
  4. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
    ..rate of oxygen exit from arterioles by diffusion a phenomenon measured by other investigators using oxygen microelectrodes and the change in microvessel blood oxygen saturation and by us using the phosphorescence quenching technique...
  5. CRCNS: Dimensionality Reduction in Cortico-Muscular Control of the Hand
    NITISH VYOMESH THAKOR; Fiscal Year: 2010
    ..To test our hypotheses, we will acquire data simultaneously from 128 single neuron microelectrodes implanted in the primary motor cortex hand representation, from 16 electromyographic electrodes implanted in ..
  6. CRCNS: Dimensionality Reduction in Cortico-Muscular Control of the Hand
    Marc Schieber; Fiscal Year: 2009
    ..To test our hypotheses, we will acquire data simultaneously from 128 single neuron microelectrodes implanted in the primary motor cortex hand representation, from 16 electromyographic electrodes implanted in ..
  7. ELECTROCHEMICAL DNA-BASED SENSORS
    Jacqueline K Barton; Fiscal Year: 2010
    ..b>Microelectrodes offer faster kinetics, as well as sensitivity in monitoring protein binding...
  8. SECRETION FROM INDIVIDUAL VESICLES
    Robert Wightman; Fiscal Year: 2009
    ..To evaluate events after exocytosis, carbon-fiber microelectrodes can be placed in tissue slices maintained in physiological buffer...
  9. SECRETION FROM INDIVIDUAL VESICLES
    ROBERT MARK WIGHTMAN; Fiscal Year: 2010
    ..To evaluate events after exocytosis, carbon-fiber microelectrodes can be placed in tissue slices maintained in physiological buffer...
  10. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2010
    ..objectives, and in which ionic and nitric oxide fluxes will be measured in real time using selective microelectrodes. We will focus on two epithelia, the epididymis, which is at the core of our research program, and the ..
  11. 3-Dimensional modeling of basal cell function in pseudostratified epithelia
    Sylvie Breton; Fiscal Year: 2009
    ..objectives, and in which ionic and nitric oxide fluxes will be measured in real time using selective microelectrodes. We will focus on two epithelia, the epididymis, which is at the core of our research program, and the ..
  12. Functional Invitro CNS and PNS Myelination Model
    Stephen Lambert; Fiscal Year: 2010
    ..will be provided not only by myotube contraction, but also by stimulating and recording microelectrodes flanking the myelination compartment, that allow for direct measurements of conduction velocity changes ..
  13. SPECTRAL AND METABOLIC BASIS OF VISUAL RESPONSES
    M Cornwall; Fiscal Year: 1993
    ..responses of these cells under background and bleach-adapted conditions will be obtained using suction microelectrodes. Changes in visual pigment content will be measured using microspectrophotometry...
  14. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2005
    ..Adsorption of neurotransmitters on carbon-fiber microelectrodes contributes to the sensitivity of these probes in vivo, but it also decreases response time...
  15. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    ROBERT MARK WIGHTMAN; Fiscal Year: 2010
    ..Both are electroactive and amenable to detection with fast-scan cyclic voltammetry at carbon-fiber microelectrodes. Three specific aims focus on new technology (1, 3, and 5), to be evaluated in anesthetized rats, and two ..
  16. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..The proposal addresses the RFA's invitation to "develop microelectrodes that can simultaneously stimulate and record and perform microdialysis or infuse chemicals"...
  17. CFTR and acid-base transporters of intestinal epithelia
    Lane Clarke; Fiscal Year: 2009
    ..cells in intact villi using BCECF ratio microfluorimetry to measure intracellular pH (pHi), single-barreled microelectrodes to measure apical membrane potential, and laser capture dissection coupled with quantitative real-time PCR ..
  18. CFTR and acid-base transporters of intestinal epithelia
    Lane Clarke; Fiscal Year: 2007
    ..cells in intact villi using BCECF ratio microfluorimetry to measure intracellular pH (pHi), single-barreled microelectrodes to measure apical membrane potential, and laser capture dissection coupled with quantitative real-time PCR ..
  19. DIFFUSION OF SUBSTANCES THROUGH THE BRAIN
    Charles Nicholson; Fiscal Year: 1999
    ..The subsequent distribution of the molecules will be measured using ion-selective microelectrodes (for tetramethylammonium and potassium), fast scan cyclic voltammetry (for dopamine) and integrative optical ..
  20. Arrays for deep brain microstimulation and recording
    Douglas McCreery; Fiscal Year: 2007
    ..An array of stimulating microelectrodes distributed through the target nucleus would permit precise control of the spatial distribution of the ..
  21. Arrays for deep brain microstimulation and recording
    Douglas McCreery; Fiscal Year: 2009
    ..An array of stimulating microelectrodes distributed through the target nucleus would permit precise control of the spatial distribution of the ..
  22. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Dewhirst; Fiscal Year: 2000
    ..Intravital microscopy and O2 microelectrodes will be used to measure temporal changes in blood flow and perivascular 02 levels and if temporal variations ..
  23. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2007
    ..nervous system diseases require implantation of electrically conductive interfaces between neural tissues and microelectrodes. Currently available metal/silicon-based devices are not stable over the long term, mostly due to gliosis and ..
  24. INNER EAR FLUID INTERACTIONS
    ALEC SALT; Fiscal Year: 1993
    ..between compartments has been monitored using a variety of techniques which involve ion-selective microelectrodes. Such electrodes can be sealed into the cochlea, permitting measurements to be made while avoiding artifacts ..
  25. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2009
    ..nervous system diseases require implantation of electrically conductive interfaces between neural tissues and microelectrodes. Currently available metal/silicon-based devices are not stable over the long term, mostly due to gliosis and ..
  26. UNIT CONTROL OF MUSCLE BLOOD FLOW
    STEVEN SEGAL; Fiscal Year: 2000
    ..Stimulation with microelectrodes will be used to test the hypothesis that (iii) muscle fiber contraction results in perfusion of MVUs along ..
  27. CARDIAC CELL VOLUME REGULATION IN CARDIOPLEGIA
    CLIVE BAUMGARTEN; Fiscal Year: 1993
    ..of cell volume and determinants of the intracellular ion activities of K+, Na+, Cl- and H+ with ion-selective microelectrodes (ISE) in both isolated ventricular myocytes and papillary muscles from adult and neonatal rabbit hearts...
  28. REFLEX PATHWAYS IN THE CONTROL OF INTESTINAL MOTILITY
    Terence Smith; Fiscal Year: 2002
    ..We will use intracellular microelectrodes and tension recordings to determine the basic responses of the longitudinal and circular muscle layers to ..