Genomes and Genes
Summary: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Publications289 found, 100 shown here
- HPV testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening: cohort studyMurat Gok
Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, Netherlands
BMJ 340:c1040. 2010..To determine whether offering self sampling of cervicovaginal material for high risk human papillomavirus (HPV) testing is an effective screening method for women who do not attend regular cervical screening programmes...
- Use of filter paper for the collection and analysis of human whole blood specimensJ V Mei
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Nutr 131:1631S-6S. 2001..These activities have created a mechanism for the validation of the filter paper blood collection device and the standardization of materials and methods for the analysis of dried blood spots...
- Dried blood spots as a source of anti-malarial antibodies for epidemiological studiesPatrick H Corran
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Malar J 7:195. 2008..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
- Pooled analysis of a self-sampling HPV DNA Test as a cervical cancer primary screening methodFang Hui Zhao
Department of Epidemiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
J Natl Cancer Inst 104:178-88. 2012....
- Long-term storage limits PCR-based analyses of malaria parasites in archival dried blood spotsJoyce Hwang
Shoklo Malaria Research Unit, Mae Sot, Tak Province, Thailand
Malar J 11:339. 2012..However, the suitability of the template obtained from dried blood spots that have been stored for long periods for DNA amplification is not known...
- Comparison of nasopharyngeal flocked swabs and aspirates for rapid diagnosis of respiratory viruses in childrenK H Chan
Department of Microbiology, The University of Hong Kong and Queen Mary Hospital, Hong Kong SAR, China
J Clin Virol 42:65-9. 2008..The quality of clinical specimens is a crucial determinant for virological diagnosis...
- Preanalytical quality improvement: from dream to realityGiuseppe Lippi
Clinical Chemistry and Hematology Laboratory, Academic Hospital of Parma, Parma, Italy
Clin Chem Lab Med 49:1113-26. 2011....
- Women find it easy and prefer to collect their own vaginal swabs to diagnose Chlamydia trachomatis or Neisseria gonorrhoeae infectionsMax A Chernesky
St Joseph s Healthcare, Hamilton, Ontario, Canada
Sex Transm Dis 32:729-33. 2005..We surveyed women's opinions on ease and preferences as to sampling after collecting their own vaginal swab and urine and a physician collection of vaginal swab and cervical swab...
- Impact of blood collection devices on clinical chemistry assaysRaffick A R Bowen
Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA
Clin Biochem 43:4-25. 2010..This review will identify sources of exogenous substances in blood specimens and propose methods to minimize their impact on clinical chemistry assays...
- Impact of biospecimens handling on biomarker research in breast cancerLoris De Cecco
Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello16, 20139 Milano, Italy
BMC Cancer 9:409. 2009....
- Biological sample collection and processing for molecular epidemiological studiesNina T Holland
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Mutat Res 543:217-34. 2003....
- Effects of tissue handling on RNA integrity and microarray measurements from resected breast cancersChristos Hatzis
Nuvera Biosciences, Woburn, MA, USA
J Natl Cancer Inst 103:1871-83. 2011..Reliable stability and yield of RNA from breast cancer tissues are important for biobanking, clinical trials, and diagnostic testing...
- Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysisPatrick Petignat
Senology and Gynaecologic Oncology Unit, Geneva University Hospitals, 1211 Geneva 14, Switzerland
Gynecol Oncol 105:530-5. 2007..To compare the detection rate of genital human papillomavirus (HPV) infection in self- and physician-obtained samples...
- Comparison of a commercial qualitative real-time RT-PCR kit with direct immunofluorescence assay (DFA) and cell culture for detection of influenza A and B in childrenFarhad Gharabaghi
Division of Microbiology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
J Clin Virol 42:190-3. 2008..Institutional pandemic planning prompted a study of the molecular detection of influenza virus from respiratory specimens in children, compared to conventional diagnostics...
- Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipidsMario Klingler
Division of Metabolic and Nutritional Medicine, Dr von Hauner Children s Hospital, University of Munich Medical Center, Lindwurmstr 4, 80337, Munich, Germany
Lipids 46:981-90. 2011..The accuracy and reliability of this new method is comparable to conventional invasive methods for the determination of the n-3 fatty acid status in humans, and it is well applicable in interventional or epidemiological studies...
- Qualification of high-recovery, flocked swabs as compared to traditional rayon swabs for microbiological environmental monitoring of surfacesGiblerto Dalmaso
GSK Manufacturing SpA, Strada Asolana n 68, San Polo di Torrile, 43056 Parma, Italy
PDA J Pharm Sci Technol 62:191-9. 2008..microRheologics flocked swabs also displayed an instant and nearly complete release of absorbed samples of more than 80%...
- Elimination of false-positive polymerase chain reaction results resulting from hole punch carryover contaminationNicolai Bonne
School of Veterinary and Biomedical Sciences, South Street, Murdoch, Western Australia 6150
J Vet Diagn Invest 20:60-3. 2008..This method was simple, cheap, and relatively rapid, and allowed for the use of a single hole punch for a series of samples, without carryover contamination and consequent false-positive results...
- Preanalytical aspects and sample quality assessment in metabolomics studies of human bloodPeiyuan Yin
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Clin Chem 59:833-45. 2013..Although excellent sample quality is essential, it can easily be compromised by undetected preanalytical errors. We set out to identify critical preanalytical steps and biomarkers that reflect preanalytical inaccuracies...
- Equivalence of self- and staff-collected nasal swabs for the detection of viral respiratory pathogensManas K Akmatov
Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
PLoS ONE 7:e48508. 2012..This may be circumvented by having the participants collect their own nasal swabs. We compared self- and staff-collected swabs in terms of swabbing quality and detection of viral respiratory pathogens...
- Causes, consequences, detection, and prevention of identification errors in laboratory diagnosticsGiuseppe Lippi
University of Verona, Verona, Italy
Clin Chem Lab Med 47:143-53. 2009..Once misidentification is detected, rejection and recollection is the most suitable approach to manage the specimen...
- Home versus clinic-based specimen collection for Chlamydia trachomatis and Neisseria gonorrhoeaeAnna S Graseck
Washington University in St Louis School of Medicine, Division of Clinical Research, Department of Obstetrics and Gynecology, Campus Box 8219, 4533 Clayton Avenue, St Louis, MO 63110, USA
Expert Rev Anti Infect Ther 9:183-94. 2011..This article describes and evaluates the effectiveness and limitations of various home screening strategies used for the detection of STIs...
- Novel nested direct PCR technique for malaria diagnosis using filter paper samplesHans Peter Fuehrer
Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Kinderspitalgasse 15, A 1090 Vienna, Austria
J Clin Microbiol 49:1628-30. 2011..Direct PCR provides a rapid, highly sensitive, and cost-effective alternative to diagnosing malaria using filter paper samples and standard nested PCR...
- Population-based outreach for Chlamydia screening in men: results from a randomized trialDelia Scholes
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Sex Transm Dis 34:837-9. 2007..To evaluate the feasibility and efficacy of population-based outreach strategies to improve genital Chlamydia trachomatis (CT) screening in men...
- Does prevention of intraperitoneal spillage when removing a dermoid cyst prevent granulomatous peritonitis?W Kondo
Department of Obstetrics and Gynaecology, centre hospitalier universitaire de Clermont Ferrand, Polyclinique de l Hotel Dieu, Clermont Ferrand, France
BJOG 117:1027-30. 2010....
- Self-collected mid-turbinate swabs for the detection of respiratory viruses in adults with acute respiratory illnessesOscar E Larios
Department of Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada
PLoS ONE 6:e21335. 2011..The objective of this study was to compare the respiratory virus isolation of flocked MT swabs compared to flocked NP swabs...
- DNA yield and quality of saliva samples and suitability for large-scale epidemiological studies in childrenA C Koni
College of Medicine, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
Int J Obes (Lond) 35:S113-8. 2011..To evaluate two saliva collection methods for DNA yield and quality as applied to a large, integrated, multicentre, European project involving the collection of biological material from children...
- Added value of an oropharyngeal swab in detection of viruses in children hospitalized with lower respiratory tract infectionLaura L Hammitt
KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
J Clin Microbiol 49:2318-20. 2011..Oropharyngeal swabs increased the number of viral infections detected by 15%, compared to collection of a nasopharyngeal swab alone. This advantage was most pronounced for detection of influenza, parainfluenza, and adenovirus...
- The potential role of self-sampling for high-risk human papillomavirus detection in cervical cancer screeningChanna E Schmeink
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, The Netherlands
Rev Med Virol 21:139-53. 2011..Even more, because self-collected samples are as good as physician-collected samples for HPV detection, self-sampling might be a suitable method for future primary cervical cancer screening...
- Effect of storage conditions on the assessment of bacterial community structure in soil and human-associated samplesChristian L Lauber
Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309 0216, USA
FEMS Microbiol Lett 307:80-6. 2010..These results suggest that many samples collected and stored under field conditions without refrigeration may be useful for microbial community analyses...
- Liquid compared with conventional cervical cytology: a systematic review and meta-analysisMarc Arbyn
Scientific Institute of Public Health, Brussels, Belgium
Obstet Gynecol 111:167-77. 2008..To compare test performance characteristics of conventional Pap tests and liquid-based cervical cytology samples...
- New views of cells in 3D: an introduction to electron tomographyRichard McIntosh
Laboratory for 3D Electron Microscopy of Cells, Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
Trends Cell Biol 15:43-51. 2005..Electron tomography can provide such information about many kinds of cells and organelles...
- A multi-country non-inferiority cluster randomized trial of frontloaded smear microscopy for the diagnosis of pulmonary tuberculosisLuis Eduardo Cuevas
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS Med 8:e1000443. 2011..More than 50 million people around the world are investigated for tuberculosis using sputum smear microscopy annually. This process requires repeated visits and patients often drop out...
- Real-time PCR detection of Plasmodium directly from whole blood and filter paper samplesBrian J Taylor
Department of Oncology, University of Alberta, Edmonton, Canada
Malar J 10:244. 2011..However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products...
- Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human fecesJordan M Nechvatal
Department of Physiology, Wayne State University, 540 E Canfield Avenue, Detroit, MI 48201, USA
J Microbiol Methods 72:124-32. 2008..Thus, fecal DNA is well preserved by methods suitable for self-collection that may be useful in future molecular epidemiological studies of intestinal bacteria and human cancer markers...
- Comparison of different culture media and storage temperatures for the long-term preservation of Streptococcus pneumoniae in the tropicsG Siberry
Department of Paediatrics, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, USA
Bull World Health Organ 79:43-7. 2001..We evaluated alternative low-cost methods, by comparing different culture media and storage temperatures...
- Nasal swab versus nasopharyngeal aspirate for isolation of respiratory virusesTerho Heikkinen
Department of Pediatrics, Turku University Hospital Department of Virology, University of Turku, Turku, Finland
J Clin Microbiol 40:4337-9. 2002..The sensitivity of nasal swabs was comparable to that of nasopharyngeal aspirates for the detection of all major respiratory viruses except respiratory syncytial virus...
- A model for harmonizing flow cytometry in clinical trialsHolden T Maecker
Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA
Nat Immunol 11:975-8. 2010..The novel use of a central laboratory may help mitigate these issues...
- Development and application of a broadly sensitive dried-blood-spot-based genotyping assay for global surveillance of HIV-1 drug resistanceChunfu Yang
Division of Global AIDS, International Laboratory Branch, DGHA, NCHHSTP, CDC, Mail Stop A 11, 1600 Clifton Road, Atlanta, GA 30333, USA
J Clin Microbiol 48:3158-64. 2010..Thus, the assay is likely to become a useful screening tool in the global resistance surveillance and monitoring of HIV-1 where multiple subtypes and CRFs are found...
- Evaluation of the ARCHITECT urine NGAL assay: assay performance, specimen handling requirements and biological variabilityFrank C Grenier
Abbott Laboratories, D 9ML, AP20, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Clin Biochem 43:615-20. 2010..Reliable clinical evaluations require a simple, robust test method for NGAL, and knowledge of specimen handling and specimen stability characteristics...
- Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNAMads Vilhelm Hollegaard
Section of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark
Electrophoresis 30:2532-5. 2009..Based on these results we conclude that DBS samples should be considered a reliable and potential resource for future genotyping studies...
- Assessment of sample collection and storage methods for multicenter immunologic research in childrenLoren A Matheson
Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
J Immunol Methods 339:82-9. 2008..This cost-effective, standardized protocol for a large multicenter trial ensures the integrity of biological samples and maximizes study participation by both large and small centers...
- Evaluation of saliva as a source of human DNA for population and association studiesDominique Quinque
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103, Leipzig, Germany
Anal Biochem 353:272-7. 2006..Thus, saliva can be considered a reliable source of DNA for a wide variety of genetic studies...
- Storage policies and use of the Danish Newborn Screening BiobankB Nørgaard-Pedersen
Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
J Inherit Metab Dis 30:530-6. 2007..The Danish NBS-Biobank has been used in several research projects for aetiological studies of a number of disorders, recently employing new sensitive multiplex technologies and genetic analyses utilizing whole-genome amplified DNA...
- Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South KoreaHai Rim Shin
Research Institute, National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
J Infect Dis 190:468-76. 2004..Little is known about the prevalence of human papillomavirus (HPV) infection in young adults in Asia...
- Enhanced rates and magnitude of immune responses detected against an HIV vaccine: effect of using an optimized process for isolating PBMCLisa S Kierstead
Vaccine and Biologics Research, Merck Research Laboratories, West Point and Wayne, PA 19087, USA
AIDS Res Hum Retroviruses 23:86-92. 2007..These studies establish the importance of optimal conditions for PBMC collection and handling to the success of a clinical development program...
- Incomplete filling of lithium heparin tubes affects the activity of creatine kinase and gamma-glutamyltransferaseG Lippi
U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
Br J Biomed Sci 69:67-70. 2012..3% and 16.6% for the half-draw and low-draw tubes, respectively. These results suggest that short-draw lithium heparin tubes might be unsuitable for testing GGT and CK using specific combinations of reagents and instrumentation...
- Same day sputum smear microscopy approach for the diagnosis of pulmonary tuberculosis in a microscopy centre at RajahmundryT Jaya Chandra
Department of Microbiology, GSL Medical College, Rajahmundry, Andhra Pradesh
Indian J Tuberc 59:141-4. 2012..This requires two (spot and morning SM) sputum sample examinations over two days. Collection of two spot samples (SS2) on the same day would reduce the number of visits, time, money and early initiation of treatment...
- Dry self-sampling versus provider-sampling of cervicovaginal specimens for human papillomavirus detection in the Inuit population of Nunavik, QuebecHelen Cerigo
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
J Med Screen 19:42-8. 2012....
- Measuring the incidence, prevalence and genetic relatedness of hepatitis C infections among a community recruited sample of injecting drug users, using dried blood spotsV D Hope
Centre for Infections, Health Protection Agency, London, UK
J Viral Hepat 18:262-70. 2011..They also enable virus characterization at genotype and nucleotide level. This would allow surveillance to inform development of harm reduction interventions, and the international evidence base for these...
- An episode of increased hemolysis due to a defective pneumatic air tube delivery systemGraham Ellis
Department of Clinical Biochemistry, St John s Hospital, Livingston West Lothian, Scotland, UK
Clin Biochem 42:1265-9. 2009..To study an episode of excessive sample hemolysis associated with a recently installed pneumatic tube system from the Accident and Emergency Department...
- Increased sensitivity of malaria detection by nested polymerase chain reaction using simple sampling and DNA extractionJ Cox-Singh
School of Medical Sciences, University of Science Malaysia, Kelantan, Malaysia
Int J Parasitol 27:1575-7. 1997....
- Long-term storage of DNA-free RNA for use in vaccine studiesKathryn L Jones
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
Biotechniques 43:675-81. 2007..g., 4 degrees C) can be achieved...
- Assessment of sample handling practices on microbial activity in sputum samples from patients with cystic fibrosisA Nelson
School of Applied Sciences, Ellison Building, University of Northumbria, Newcastle upon Tyne, UK
Lett Appl Microbiol 51:272-7. 2010..The aim of this study was to quantitatively and qualitatively assess the effect of sample storage on the metabolically active microbial community found in sputum samples from patients with cystic fibrosis (CF)...
- Identification of blood culture isolates directly from positive blood cultures by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry and a commercial extraction system: analysis of performance, cost, and turnaround timePhilippe R S Lagacé-Wiens
Department of Medical Microbiology and Infectious Diseases, University of Manitoba Winnipeg, Manitoba, Canada
J Clin Microbiol 50:3324-8. 2012..However, the use of MALDI-TOF for direct identification is accurate and should result in reduced turnaround time to identification...
- Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanksPatrizia Bernini
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
J Biomol NMR 49:231-43. 2011..Appropriate procedures for blood derivatives collection and urine preservation/storage that allow maintaining as much as possible the original metabolic profile of the fresh samples emerge, and are proposed as SOPs for biobanking...
- Preanalytical quality control program - an overview of results (2001-2005 summary)Ma Jesus Alsina
SEQC Committee for the Quality of the Extraanalytical Phase, Spain
Clin Chem Lab Med 46:849-54. 2008..Preanalytical variables, such as sample collection, handling, transport, and storage, may affect patient results. The number of errors in the preanalytical phase may decrease by following standardized procedures...
- Detection of Puumala and Rift Valley Fever virus by quantitative RT-PCR and virus viability tests in samples of blood dried and stored on filter paperJonas Näslund
Department of Clinical Microbiology, Division of Infectious Diseases, Umea University, SE 901 85 Umea, Sweden
J Virol Methods 178:186-90. 2011..This approach might facilitate sampling and analysis of other RNA viruses from human or animal sources and could be used for field studies in remote areas or in developing countries...
- Phosphoprotein stability in clinical tissue and its relevance for reverse phase protein microarray technologyVirginia Espina
Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, USA
Methods Mol Biol 785:23-43. 2011..Based on this analysis we have established tissue procurement guidelines for clinical research with an emphasis on quantifying phosphoproteins by RPMA...
- Lymph node harvest in colon cancer specimens depends on tumour factors, patients and doctors, but foremost on specimen handlingKristian Storli
Department of Surgery, Haraldsplass Deaconal Hospital, Bergen, Norway
APMIS 119:127-34. 2011..Several tumour and individual patient characteristics, surgical approach and specimen handling may influence lymph node yield and theoretically, TNM staging...
- Agreement between paired blood gas values in samples transported either by a pneumatic system or by human courierJohn Victor Peter
Medical ICU, Christian Medical College and Hospital, Vellore, India
Clin Chem Lab Med 49:1303-9. 2011..Rapid accurate assessment of metabolic derangements is crucial in the critically ill. We evaluated if arterial blood gas (ABG) samples transported through a pneumatic tube system (PTS) agreed with values transported by a human courier...
- Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal diseaseCatherine E Garner
Clinical Science at South Bristol, Bristol Royal Infirmary, Marlborough St, Bristol BS2 8HW, UK
FASEB J 21:1675-88. 2007..difficile, and C. jejuni were each significantly different. These findings could lead the way to the development of a rapid diagnostic device based on VOC detection...
- Storage and stability of IgG and IgM monoclonal antibodies dried on filter paper and utility in Neisseria meningitidis serotyping by Dot-blot ELISAAline S Ferraz
Immunology Section, Adolfo Lutz Institute, Sao Paulo, Sao Paulo, Brazil
BMC Infect Dis 8:30. 2008..meningitidis by dot-blot ELISA...
- Managing the pre- and post-analytical phases of the total testing processRobert Hawkins
Department of Laboratory Medicine, Tan Tock Seng Hospital, Tan Tok Seng, Singapore
Ann Lab Med 32:5-16. 2012....
- Assessing a novel room-temperature RNA storage medium for compatibility in microarray gene expression analysisGilberto E Hernandez
DNA Array Core Facility, The Scripps Research Institute, La Jolla, California 92037, USA
Biotechniques 47:667-8, 670. 2009..The ability to stabilize RNA samples at ambient temperatures for extended time periods will have tremendous use, particularly for sample shipment to core facilities...
- Solution densities and estimated total protein contents associated with inappropriate flotation of separator gel in different blood collection tubesRonald C Faught
Clinical Laboratory, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Arch Pathol Lab Med 135:1081-4. 2011..In automated analytical systems, gel flotation can lead to mechanical disruption and potential inaccurate result reporting upon aspiration into instrument sampling probes...
- Development of chip-compatible sample preparation for diagnosis of infectious diseasesMarion Ritzi-Lehnert
Institut fuer Mikrotechnik Mainz GmbH, Mainz, Germany
Expert Rev Mol Diagn 12:189-206. 2012..In this article, the most recent advances in on-chip sample preparation are reviewed for microfluidic-based diagnosis of infectious diseases...
- The challenge and importance of standardizing pre-analytical variables in surgical pathology specimens for clinical care and translational researchD G Hicks
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
Biotech Histochem 87:14-7. 2012..Inaccurate results owing to compromised tissue quality can lead to false positive or false negative results with therapeutic consequences that can harm patients and affect their eventual outcome...
- Organizational issues in providing high-quality human tissues and clinical information for the support of biomedical researchWalter C Bell
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
Methods Mol Biol 576:1-30. 2010..In this review, we describe, based on our experience, the major issues that should be addressed in designing and establishing a tissue repository...
- Detection and species identification of Leishmania DNA from filter paper lesion impressions for patients with American cutaneous leishmaniasisAndrea K Boggild
Tropical Disease Unit, Division of Infectious Diseases, Toronto General Hospital, Toronto, Canada
Clin Infect Dis 50:e1-6. 2010..We compared traditional diagnostic methods with a molecular noninvasive filter paper-based method for the diagnosis of cutaneous leishmaniasis...
- Quality management for the collection of biological samples in multicentre studiesJ Peplies
Bremen Institute for Prevention Research and Social Medicine, University of Bremen, Germany
Eur J Epidemiol 25:607-17. 2010..Overall compliance with the QMS-BS was good, with some exceptions mainly related to sample control. In conclusion the QMS-BS is a valuable tool for the management of biological sample collection in epidemiological multicentre studies...
- Early diagnosis of human immunodeficiency virus-1 infection in infants with the NucliSens EasyQ assay on dried blood spotsR R Lilian
Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, 8 Blackwood Avenue, Parktown, Johannesburg, South Africa
J Clin Virol 48:40-3. 2010..The VL assay routinely used in the country has not previously been assessed on DBS for early infant diagnosis...
- Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis?A Cattamanchi
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
J Clin Microbiol 48:2433-9. 2010..Further research should focus on alternative approaches to optimizing smear microscopy, such as light-emitting diode fluorescence microscopy and same-day sputum collection strategies...
- Prevalence of type-specific human papillomavirus in endocervical, upper and lower vaginal, perineal and vaginal self-collected specimens: Implications for vaginal self-collectionJerome L Belinson
Department of Gynecology, The Cleveland Clinic Foundation, Cleveland, OH, USA
Int J Cancer 127:1151-7. 2010..The principal cause of the lower specificity of self-collected specimens is HR-HPV present solely in the vagina, which is not associated with > or = CIN 2...
- Radiological and pathological size estimations of pure ductal carcinoma in situ of the breast, specimen handling and the influence on the success of breast conservation surgery: a review of 2564 cases from the Sloane ProjectJ Thomas
Pathology Department, Western General Hospital and Breakthrough Breast Cancer Research Unit, Edinburgh EH4 2XU, UK
Br J Cancer 102:285-93. 2010..We have correlated these sizes with histological grade, specimen-handling methods, particularly the use of specimen slice radiographs, and the success or failure of breast-conserving surgery (BCS)...
- Dried blood spot HIV-1 RNA quantification using open real-time systems in South Africa and Burkina FasoJohannes Viljoen
Africa Center for Health and Population Studies, University of KwaZulu Natal, Durban, South Africa
J Acquir Immune Defic Syndr 55:290-8. 2010..Our findings strongly advocate the implementation of DBS HIV-1 RNA testing in remote areas from low-income and middle-income countries...
- HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancerT C Wright
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
JAMA 283:81-6. 2000..In many other regions of the world, there is only limited access to cervical cancer screening...
- To continue or discontinue storage of cryopreserved embryos? Patients' decisions in view of their child wishV Provoost
Bioethics Institute Ghent, Ghent University, Blandijnberg 2, B 9000 Ghent, Belgium
Hum Reprod 26:861-72. 2011....
- Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited settingG U van Zyl
Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service, Tygerberg, South Africa
Clin Infect Dis 52:264-70. 2011..Recently, the use of pooling strategies with a clinically appropriate viral load threshold was shown to be accurate and efficient for monitoring when the prevalence of virologic failure is low...
- The use of FTA® filter papers for diagnosis of avian influenza virusE M Abdelwhab
Institute of Poultry Diseases, Free Berlin University, Koenigsweg 63, 14163 Berlin, Germany
J Virol Methods 174:120-2. 2011..The use of FTA® cards will facilitate safe transport of samples for molecular diagnosis of AIV avoiding the need for an uninterrupted cold storage...
- Improved sensitivity of vaginal self-collection and high-risk human papillomavirus testingJerome L Belinson
Preventive Oncology International, Inc Cleveland Heights, OH, USA
Int J Cancer 130:1855-60. 2012..Large population-based screening "events" in low-resource settings could be achieved by promoting self-collection and centralized high-throughput, low-cost testing by PCR-based MALDI-TOF...
- E-mail-based symptomatic surveillance combined with self-collection of nasal swabs: a new tool for acute respiratory infection epidemiologyManas K Akmatov
Department of Infection Genetics, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Int J Infect Dis 15:e799-803. 2011..We examined the feasibility of combining communication by e-mail and self-collection of nasal swabs for the prospective detection of acute respiratory infections in a non-medical setting...
- Quality improvement in laboratory medicine: extra-analytical issuesGiuseppe Lippi
Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico GB Rossi, Piazzale Scuro, Verona, Italy
Clin Lab Med 28:285-94, vii. 2008..The article focuses on appropriateness of the test request, patient and sample identification, criteria for acceptance and rejection of specimens, and the communication and interpretation of results...
- EGFR and KRAS mutations detection on lung cancer liquid-based cytology: a pilot studyUmberto Malapelle
Scienze Biomorfologiche e Funzionali, University Federico II of Naples, Naples, Italy
J Clin Pathol 65:87-91. 2012..Although time-consuming, LCM makes direct sequencing highly sensitive even on LBC preparations containing only a few cells...
- Evaluation of a sticky trap for collecting Aedes (Stegomyia) adults in a dengue-endemic area in ThailandLuca Facchinelli
Parasitology Unit, Department of Public Health Sciences, University of Rome La Sapienza, Rome, Italy
Am J Trop Med Hyg 78:904-9. 2008..The percentage of positive sticky-trap catches was double for Ae. aegypti and almost 20 times higher for Ae. albopictus. Operational benefits of the sticky trap are discussed within the context of the results obtained...
- Comparative performance of human papillomavirus DNA testing using novel sample collection methodsJulia C Gage
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, MSC 7231, Rockville, MD 20852, USA
J Clin Microbiol 49:4185-9. 2011..HC2 is likely more clinically specific, although possibly less sensitive, than either PCR test. Thus, use of HC2 on cervicovaginal specimens for screening could result in fewer referrals compared to LA and Amplicor...
- Tuberculosis in children: reassessing the need for improved diagnosis in global control strategiesP Eamranond
Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
Int J Tuberc Lung Dis 5:594-603. 2001..In this review, we present compelling evidence that research agendas and TB control programs should be reassessed and possibly revised to deal with the global disease caused by PPTB...
- Self-sampling of vaginal fluid and high-risk human papillomavirus testing in women aged 50 years or older not attending Papanicolaou smear screeningM Lindell
Department of Pathology and Cytology, Uppsala University Hospital, Sweden
BJOG 119:245-8. 2012..To study the value of self-sampling of vaginal fluid at home in combination with high-risk human papillomavirus (HPV) testing in a cohort of older women not attending Papanicolaou (Pap) smear screening...
- Using rapid diagnostic tests as source of malaria parasite DNA for molecular analyses in the era of declining malaria prevalenceDeus S Ishengoma
National Institute for Medical Research, Tanga Centre, Bombo Road, P, O Box 5004, Tanga, Tanzania
Malar J 10:6. 2011....
- Best practice in forensic entomology--standards and guidelinesJens Amendt
Institute of Forensic Medicine, University of Frankfurt, Kennedyallee 104, 60596, Frankfurt Main, Germany
Int J Legal Med 121:90-104. 2007....
- Impact of intensified testing for urogenital Chlamydia trachomatis infections: a randomised study with 9-year follow-upBerit Andersen
Department of Public Health Interventions, Randers Hospital, Skovlyvej, 8900 Randers, Denmark
Sex Transm Infect 87:156-61. 2011..The long-term clinical benefit in terms of avoided infertility and ectopic pregnancy is unknown...
- International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handlingHemamali Samaratunga
Department of Pathology, Aquesta Pathology, Brisbane, QLD, Australia
Mod Pathol 24:6-15. 2011....
- Diagnosis of pulmonary tuberculosis in children: new advancesHeather J Zar
Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital, University of Cape Town, South Africa
Expert Rev Anti Infect Ther 8:277-88. 2010..Greater efforts to obtain a microbiologic diagnosis should be made in children, even in primary care settings. Further research to develop a more accurate, cost-effective and simple diagnostic test for childhood TB is urgently needed...
- Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trialsMarta Bull
Children s Hospital and Regional Medical Center, Seattle, WA, USA
J Immunol Methods 322:57-69. 2007..This narrow window for specimen processing has important implications in selecting and monitoring clinical sites with laboratory capacity to perform these procedures in future clinical trials...
- Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterizationAdriana Weinberg
University of Colorado Denver School of Medicine, Denver, CO, USA
Clin Vaccine Immunol 16:1176-86. 2009....
- Stability of dried blood spots for HIV-1 drug resistance analysisAnna C Hearps
Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne 3004, Australia
Curr HIV Res 8:134-40. 2010....
- Effect of sampling time on the culturability of airborne fungi and bacteria sampled by filtrationKate T H Durand
University of Washington, School of Public Health and Community Medicine, Department of Environmental Health, Seattle 98195, USA
Ann Occup Hyg 46:113-8. 2002..This suggests that increased sampling time does not affect the viability of the organisms commonly found in the air at composting facilities...
- A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocolsWarwick B Dunn
Bioanalytical Sciences Group, School of Chemistry, Manchester Interdiscplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, M1 7ND, UK
Int J Epidemiol 37:i23-30. 2008....
- Off-line exhaled nitric oxide measurements in childrenM Barreto
II Pediatric Department, University La Sapienza, Rome, Italy
Pediatr Pulmonol 32:159-67. 2001..Once standardized, the off-line eNO technique using 1-L gas collection bags will provide results similar to those recorded on-line...
- Optimizing buccal cell DNA yields in mothers and infants for human leukocyte antigen genotypingAudrey F Saftlas
Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
Am J Epidemiol 160:77-84. 2004..Cytobrush sampling of the mouth's gutter areas can enhance DNA yield in mothers but not in young infants. DNA yields can be further optimized by controlling mailing and storage conditions...
- Detection of carcinogenic human papillomavirus in specimens collected with a novel self-sampling devicePhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
J Clin Microbiol 44:2158-9. 2006..The kappa value was 0.66 (95% confidence interval, 0.53 to 0.78), with an 83% overall test agreement and a 68% positive test agreement...
- Classifying laboratory incident reports to identify problems that jeopardize patient safetyMichael L Astion
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, USA
Am J Clin Pathol 120:18-26. 2003....
- Novel Method for Sample ProcessingYajuan Jiang; Fiscal Year: 2006..g. fine needle aspirates or other biopsy materials). Problems associated with specimen handling include cell loss and cell clumping...
- Comprehensive Molecular Diagnosis for Food and Waterborne EnteropathogensEric R Houpt; Fiscal Year: 2011..is to develop sensitive PCR-based diagnostics directly usable on stool with comparable or better sensitivity to existing technologies, which have clear deficincies in sensitivity of pathogen detection, throughput, and specimen handling.
- Automated point-of-care PCR for hemorrhagic fever diagnosisAlan L Rothman; Fiscal Year: 2010..of a proprietary assay tube system and analyzer device, provides a closed system for rapid, automated specimen handling and nucleic acid detection...
- DEVELOPMENT OF A SALIVA HOMOCYSTEINE ASSAY SYSTEMTimothy Carlson; Fiscal Year: 1999..The elaborate specimen handling necessary to prevent this is frequently not achievable in actual practice...
- Macromolecular Crystallography at the National Synchrotron Light SourceRobert M Sweet; Fiscal Year: 2011..collimation of modern x-ray sources, the use of micron-sized crystals, the development of robotic cryogenic specimen handling, and the simultaneous measurement of UV, Visible, or Raman IR spectra with x-ray diffraction...
- Macromolecular Crystallography at the National Synchrotron Light SourceRobert M Sweet; Fiscal Year: 2013..and collimation of modern x-ray sources, use of micron-sized crystals, development of robotic cryogenic specimen handling, and simultaneous measurement of UV, Visible, or Raman IR spectra with x-ray diffraction...
- HEMOQUANT DETECTION OF COLORECTAL NEOPLASIADavid Ahlquist; Fiscal Year: 1990..central office coordinate all subsequent operations including patient and physician correspondence, specimen handling, and data management. All fecal blood assays are done at Mayo laboratories...
- QUANTITATIVE MEASURES IN BREAST CANCER PATHOLOGYMartha Hutchinson; Fiscal Year: 1990..However, until now the necessity for special specimen handling, laborious methods, and/or expensive computers for quantitative cell image analysis have limited the ..
- NIAID Specimen RepositoryMARK MANAK; Fiscal Year: 2010..Provide shipping materials and documents, technical assistance and training to Site personnel and study teams on specimen handling and shipping
- NIAID Specimen RepositoryMark M Manak; Fiscal Year: 2009..Provide shipping materials and documents, technical assistance and training to Site personnel and study teams on specimen handling and shipping
- NIAID Specimen RepositoryMichael Waddington; Fiscal Year: 2011..Provide shipping materials and documents, technical assistance and training to Site personnel and study teams on specimen handling and shipping
- Wide Angle X-ray Scattering for Commercial Applications in Drug Lead DiscoveryRichard Walter; Fiscal Year: 2009..and associated control systems by constructing a portable, wide-angle camera with robotic control of specimen handling;(2) to develop a software package to automate downstream data processing and analysis by updating and ..
- INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEMSTEPHEN RENSHAW; Fiscal Year: 1991..3. Decreasing the risk of infection of laboratory personnel by decreasing the amount of manual specimen handling. Phase I includes an evaluation of both the hardware and software prior to designing a sophisticated Phase ..
- Purchase of a FEI Titan Krios for 3-D EMKenneth Taylor; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Effect of Oxidant Load on HPV Persistence and CIN (SIL)Anna Giuliano; Fiscal Year: 2008..abstract_text> ..
- Urinary Symptoms in Adolescent Females: STI or UTI?Jill Huppert; Fiscal Year: 2004..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
- CryoEM Equipment Enhancements for Florida State UniversityKenneth Taylor; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Liquid Chromatography Mass Spectrometry systemAdrian Franke; Fiscal Year: 2005..abstract_text> ..
- Purchase of a large format CCD camera for 3-D EMKenneth Taylor; Fiscal Year: 2005..The new instrumentation will allow for development of algorithms for increasing the area that can be reconstructed by electron tomography which may need corrections for focus gradient and for imaging distortions. ..
- Predicting Metastasis to Lymph NodesDavid Rimm; Fiscal Year: 2008....
- Ectopic Pregnancy: Assessing Long-Term Trends in Rates and Risk FactorsDelia Scholes; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Multiplexed pathogen detection by on-chip amplificationDarrell Chandler; Fiscal Year: 2008..unreadable] [unreadable]..
- Determination of OA Pathology by Biomarker DatingVirginia Kraus; Fiscal Year: 2007..We refer to the technique of quantifying the D-aspartate content of cartilage macromolecules as "biomarker dating". ..
- Neoadjuvant Cytokine Immunotherapy by PLA MicrospheresMichael Sabel; Fiscal Year: 2007..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
- Diagnostic protein array for respiratory infectionsDarrell Chandler; Fiscal Year: 2008..The underlying platform developed herein will likewise find broad application in many areas of disease surveillance, with an emphasis on point-of-use applications. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Pregnancy-Related Sleep Disturbances May Increase Pregnancy ComplicationsMichele Okun; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MALIGNANT COMPLICATIONS OF CHRONIC HCVChristopher Loffredo; Fiscal Year: 2009..This set of aims and molecular epidemiology methods represents a novel approach to the study of the malignant complications of chronic HCV infection. ..
- Early experience and low 5-HT markers in alcohol abuseMark Laudenslager; Fiscal Year: 2009..Finally, involvement of the HPA axis in these relationships will be investigated as an exploratory goal. ..
- Gender Differences in Bladder Cancer Risk FactorsChristopher A Loffredo; Fiscal Year: 2010..squamous). The results of this study will help establish the best preventive measures for bladder cancer in men and women, by appropriately directing the resources of the public health sector for effective cancer control. ..
- Effects of Soy on Estrogens in Breast Fluid and UrineGertraud Maskarinec; Fiscal Year: 2010..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
- LIPID METABOLISM IN FAT CELLSWen Guo; Fiscal Year: 2010..Together, these studies will provide new insights into the stress-induced regulation of lipogenesis in adipocytes, a potentially important avenue for modulating energy balance. ..
- The ethics of consent for the public release of potentially identifiable DNA dataAmy McGuire; Fiscal Year: 2009..Moreover, it will increase our understanding of participants'judgments and attitudes toward data sharing, which will improve the overall conduct of biomedical research, build public trust, and foster research participation. ..
- GENETIC MECHANISMS THAT POTENTIATE HUMAN SPERMATOGENESISSTEPHEN KRAWETZ; Fiscal Year: 2009..This milestone provides the foundation to isolate and functionally characterize the associated agents that open chromatin domains. ..
- Novel Application of Infection Control Strategies to Limit Transmission of ESBL'SEbbing Lautenbach; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Utilizing Saliva to Measure Bone TurnoverSreenivas Koka; Fiscal Year: 2007..We anticipate that our results will identify how salivary biomarkers can be used to assess the osseo-status of patients with, or at risk for, osteoporosis. [unreadable] [unreadable] [unreadable] [unreadable]..
- CCBAR Workshop 2006-2007STACY LINDAU; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- New Tool to Study Neurochemical Modulation of FeedingSCOTT SHIPPY; Fiscal Year: 2005..The unique capabilities of low-flow push-pull perfusion complement other sampling methodologies and are widely applicable to in vivo sampling studies. ..
- ED Screening and Interventions for Hazardous Alcohol UseBrigitte Baumann; Fiscal Year: 2004..The intent of this proposal is to join with 12 other participating EDs in a joint effort of SBIRT training and ED patient intervention. ..
- Automation Technology for High Throughput Cryo-EMRobert Glaeser; Fiscal Year: 2004..High throughput determination of the structure of large macromolecular assemblies will greatly enhance our understanding of the ways in which complex biochemical operations are carried out at the subcellular level. ..
- The Effect of Black Cohosh Extract on the Human BreastEdward Sauter; Fiscal Year: 2004..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
- HIV-1 resistance to nucleoside analoguesDaniel Kuritzkes; Fiscal Year: 2004..Better understanding of the virologic, genetic, and biochemical aspects of AZT/3TC dual resistance will help direct therapy and may lead to better therapeutic strategies in the future. ..
- AQUA: A New Quantitative in situ Proteomic AssayDavid Rimm; Fiscal Year: 2004....
- THE CLOUD ADULTRobert Sherertz; Fiscal Year: 2003..aureus associated with a viral URI, have been shown to cause outbreaks. Understanding the "cloud phenomenon" may facilitate S.aureus outbreak prevention and possibly the transmission of other pathogens, as well. ..
- HUMAN RETROVIRUS-5 AND ARTHRITISRobin Patel; Fiscal Year: 2002..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
- EPITHELIAL GENE TRANSCRIPTION IN INTESTINAL PATHOLOGYGary Wu; Fiscal Year: 2002..Ultimately, once the mechanisms by which DRA gene transcription is regulated in the normal colon have been elucidated, DRA may be a useful model with which to investigate how gene expression is altered in pathobiology. ..
- ESTABLISHMENT AND REGULATION OF CELL/CELL ADHESIONDavid Rimm; Fiscal Year: 2002..We use this tool throughout this proposal in in vitro adhesion assays and also as a unique probe for the homotypic interaction, as a mechanism to assess the co-precipitable components in the adhesion complex. ..
- NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITYGertraud Maskarinec; Fiscal Year: 2002....
- Altered Breast Methylation after Low/Hi Dose IsoflavonesEdward Sauter; Fiscal Year: 2005..abstract_text> ..
- Enhancement of antimicrobics by electrical currentRobin Patel; Fiscal Year: 2007..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
- Equipment for Correlative LM/EM by High Pressure Freezing and TomographyKent McDonald; Fiscal Year: 2007..In turn, this better understanding of mechanism will promote more effective treatments for disease intervention. [unreadable] [unreadable] [unreadable]..
- Human papillomavirus as a risk factor for HIV infectionPETER CHIN HONG; Fiscal Year: 2007..unreadable] [unreadable]..
- Soy Consumption and Breast Tissue ProliferationGertraud Maskarinec; Fiscal Year: 2006....
- GENOME RESOURCE BANKING OF RARE FELID POPULATIONSWilliam Swanson; Fiscal Year: 2006..abstract_text> ..
- Egypt Smoking Prevention Research InitiativeChristopher Loffredo; Fiscal Year: 2006..The establishment of the ESPRI and the professional development of Egyptian investigators and Research Associates will accelerate Egypt's efforts to become tobacco free. ..
- PCR assays to detect individual pneumococcal serotypesLORRY RUBIN; Fiscal Year: 2006..Furthermore, they will be critical for determining the effects of current and future pneumococcal vaccines on serotype-specific carriage. ..
- Fitness of Enfuvirtide-(T-20)-Resistant HIV-1Daniel Kuritzkes; Fiscal Year: 2006..Results of these studies will provide a deeper understanding of the molecular, virologic, and clinical consequences ofT-20 resistance, and may help guide the use of T-20 in salvage therapy. ..
- Functional Assessment of Pulmonary Toxicity with MRMG Johnson; Fiscal Year: 2005..abstract_text> ..
- From drug Use to Addiction: Unearthing the SwitchesHoward Gutstein; Fiscal Year: 2005..It is hoped that these findings will eventually lead to improved treatments for these devastating conditions. ..
- CLINICAL RESEARCH CURRICULUMDavid Ransohoff; Fiscal Year: 2004..abstract_text> ..
- Colonoscopy Utilization in North CarolinaDavid Ransohoff; Fiscal Year: 2006..It may provide the basis to develop interventions to optimize the allocation of colonoscopy effort in programs of CRC screening and surveillance. ..
- LEICA EM UC/6 CRYO-ULTRAMICROTOME AND ACCESSORIESKent McDonald; Fiscal Year: 2005..Use by regional investigators will be encouraged in the time remaining after core investigator use. UC Berkeley will provide space, staff, and funds for maintaining the equipment. ..