erythrocyte indices

Summary

Summary: ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).

Top Publications

  1. ncbi Importance of RDW value in differential diagnosis of hypochrome anemias
    D Aslan
    Department of Pediatric Hematology, Ihsan Dogramaci Children s Hospital, Hacettepe University, Ankara, Turkey
    Am J Hematol 69:31-3. 2002
  2. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
  3. ncbi Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Arch Pathol Lab Med 133:628-32. 2009
  4. pmc Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume
    Ernest Beutler
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 106:740-5. 2005
  5. pmc Red blood cell distribution width and the risk of death in middle-aged and older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Ste 3C309, Bethesda, MD 20814, USA
    Arch Intern Med 169:515-23. 2009
  6. ncbi Elevated red blood cell distribution width predicts mortality in persons with known stroke
    Chizobam Ani
    Department of Medicine, Charles Drew University of Medicine and Science, USA
    J Neurol Sci 277:103-8. 2009
  7. ncbi Red cell distribution width is a prognostic factor in severe sepsis and septic shock
    You Hwan Jo
    Department of Emergency Medicine, Seoul National University Bundang Hospital, Gyeonggi do 463 707, Republic of Korea
    Am J Emerg Med 31:545-8. 2013
  8. ncbi Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension
    Chetan V Hampole
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Am J Cardiol 104:868-72. 2009
  9. pmc Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:461-74. 2012
  10. ncbi The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention
    Turgay Isik
    Department of Cardiology, Balikesir University, School of Medicine, Cagis Campus, Balikesir, Turkey
    Atherosclerosis 224:143-9. 2012

Research Grants

Detail Information

Publications230 found, 100 shown here

  1. ncbi Importance of RDW value in differential diagnosis of hypochrome anemias
    D Aslan
    Department of Pediatric Hematology, Ihsan Dogramaci Children s Hospital, Hacettepe University, Ankara, Turkey
    Am J Hematol 69:31-3. 2002
    ..These observations could be kept in mind in the differential diagnosis of deltabeta-TT from beta-TT and IDA by determining the red blood cell count, red cell indices, and RDW only...
  2. pmc Red cell distribution width and mortality in older adults: a meta-analysis
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 65:258-65. 2010
    ..Whether RDW is prognostic in more representative community-based populations is unclear...
  3. ncbi Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Arch Pathol Lab Med 133:628-32. 2009
    ..A strong independent association has been recently observed between elevated red blood cell distribution width (RDW) and increased incidence of cardiovascular events...
  4. pmc Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume
    Ernest Beutler
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 106:740-5. 2005
    ..1% and 2.77% and to 4.29% and 3.6%, respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood cell count do not apply to all ethnic groups...
  5. pmc Red blood cell distribution width and the risk of death in middle-aged and older adults
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Ste 3C309, Bethesda, MD 20814, USA
    Arch Intern Med 169:515-23. 2009
    ..In patients with symptomatic cardiovascular disease (CVD), RDW is associated with mortality. However, it has not been demonstrated that RDW is a predictor of mortality independent of nutritional deficiencies or in the general population...
  6. ncbi Elevated red blood cell distribution width predicts mortality in persons with known stroke
    Chizobam Ani
    Department of Medicine, Charles Drew University of Medicine and Science, USA
    J Neurol Sci 277:103-8. 2009
    ..We assessed the association of RDW with stroke, and its effect on mortality among persons with stroke...
  7. ncbi Red cell distribution width is a prognostic factor in severe sepsis and septic shock
    You Hwan Jo
    Department of Emergency Medicine, Seoul National University Bundang Hospital, Gyeonggi do 463 707, Republic of Korea
    Am J Emerg Med 31:545-8. 2013
    ..This study was performed to investigate the association of red cell distribution width (RDW) with 28-day mortality in patients with severe sepsis and septic shock...
  8. ncbi Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension
    Chetan V Hampole
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Am J Cardiol 104:868-72. 2009
    ..39 for NT-pro-BNP). Adding NT-pro-BNP to RDW did not improve the prediction of mortality. In conclusion, RDW is independently associated with death in patients with PH and performs better as a prognostic indicator than NT-pro-BNP...
  9. pmc Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits
    Keyue Ding
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:461-74. 2012
    ..To identify common genetic variants influencing red blood cell (RBC) traits...
  10. ncbi The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention
    Turgay Isik
    Department of Cardiology, Balikesir University, School of Medicine, Cagis Campus, Balikesir, Turkey
    Atherosclerosis 224:143-9. 2012
    ..The purpose of this study was to evaluate the predictive value of red cell distribution width (RDW) on the electrocardiographic no-reflow phenomenon in patients undergoing primary percutaneous coronary intervention (PCI)...
  11. ncbi Red blood cell distribution width is a potential prognostic index for liver disease
    Zhide Hu
    Department of Laboratory Medicine, General Hospital of Ji nan Military Command Region, Ji Nan, PR China
    Clin Chem Lab Med 51:1403-8. 2013
    ..Red blood cell distribution width (RDW) is increased in liver disease. Its clinical significance, however, remains largely unknown. The aim of this study was to identify whether RDW was a prognostic index for liver disease...
  12. ncbi Alpha and beta thalassemia
    Herbert L Muncie
    Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am Fam Physician 80:339-44. 2009
    ..Persons with the thalassemia trait have a normal life expectancy. Persons with beta thalassemia major often die from cardiac complications of iron overload by 30 years of age...
  13. ncbi Red blood cell distribution width as an independent predictor of all-cause mortality in out of hospital cardiac arrest
    Joonghee Kim
    Department of Emergency Medicine, Seoul National University Bundang Hospital, Gumi Ro, Bundang gu, Seongnam si, Gyeonggi do 463 707, Republic of Korea
    Resuscitation 83:1248-52. 2012
    ..Recent studies found that elevated red cell distribution width (RDW) is a strong predictor of mortality in critically ill patients. We investigated the prognostic significance of RDW in out-of-hospital cardiac arrest (OHCA) victims...
  14. ncbi Red cell distribution width in patients with prehypertension and hypertension
    Asli Tanindi
    Department of Cardiology, Cankiri State Hospital, Aksu mahallesi, Ogretmenler, Sokak, Cankiri, Turkey
    Blood Press 21:177-81. 2012
    ....
  15. ncbi Relationship between red cell distribution width and microalbuminuria: a population-based study of multiethnic representative US adults
    Luis Afonso
    Division of Cardiology, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    Nephron Clin Pract 119:c277-82. 2011
    ..Microalbuminuria (MA), a renal marker of vascular injury, is an independent predictor of cardiovascular (CV) events. Red cell distribution width (RDW), an emerging CV risk predictor, has not been evaluated for its association with MA...
  16. ncbi Red cell distribution width and risk of peripheral artery disease: analysis of National Health and Nutrition Examination Survey 1999-2004
    Sandip K Zalawadiya
    Division of Cardiology, Department of Internal Medicine, Detroit Medical Center Wayne State University, Detroit, MI 48201, USA
    Vasc Med 17:155-63. 2012
    ..0001). In conclusion, higher levels of RDW are independently associated with a higher risk of PAD and can significantly improve the risk prediction beyond that estimated by ACC/AHA-defined PAD screening criteria...
  17. ncbi Can red cell distribution width help to discriminate benign from malignant biliary obstruction? A retrospective single center analysis
    Yavuz Beyazit
    Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
    Hepatogastroenterology 59:1469-73. 2012
    ..The aim of this study is to evaluate the usefulness of red cell distribution width (RDW) in differentiating benign and malignant causes of obstructive jaundice...
  18. ncbi Clinical utility of red cell distribution width in alcoholic and non-alcoholic liver cirrhosis
    Sandra Milić
    Division of Gastroenterology, Department of Internal Medicine, Rijeka University Hospital Center, Rijeka, Croatia
    Coll Antropol 35:335-8. 2011
    ..697). Our study showed that RDW had not any clinical value in differentiation of anemia neither in alcoholic and non-alcoholic liver cirrhosis nor in severity of liver disease...
  19. ncbi Elevated red cell distribution width level predicts worse postinterventional thrombolysis in myocardial infarction flow reflecting abnormal reperfusion in acute myocardial infarction treated with a primary coronary intervention
    Ahmet Karabulut
    Department of Cardiology, Istanbul Medicine Hospital, Istanbul, Turkey
    Coron Artery Dis 23:68-72. 2012
    ..Herein, we aimed to demonstrate the impact of an elevated RDW level on the postinterventional thrombolysis in myocardial infarction (TIMI) flow in AMI patients...
  20. ncbi Assessment of red cell distribution width (RDW) in patients with coronary artery ectasia
    Orhan Dogdu
    Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey
    Clin Appl Thromb Hemost 18:211-4. 2012
    ..Red cell distribution width (RDW) is a measure of heterogeneity in the size of red blood cell. In this study, we aimed to investigate RDW levels in patients with CAE...
  21. ncbi Association of the red cell distribution width with red blood cell deformability
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20814, USA
    Adv Exp Med Biol 765:211-6. 2013
    ..The resultant hypoxia may help to explain the previously reported increased risk for CVD events associated with elevated RDW...
  22. ncbi Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention
    Shuta Tsuboi
    Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Circ J 77:456-61. 2013
    ..Diabetes mellitus increases oxidative stress and vascular inflammation, which accelerate atherosclerosis. However, the relationship between RDW and long-term outcome in diabetic patients with coronary artery disease (CAD) is unclear...
  23. ncbi The red cell distribution width as a prognostic indicator in idiopathic pulmonary fibrosis
    Steven D Nathan
    Advanced Lung Disease and Lung Transplant Program, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, USA
    Chest 143:1692-8. 2013
    ..The red cell distribution width (RDW) is a parameter that is routinely reported with all CBC counts. We sought to test the prognostic usefulness of this parameter in a well-defined cohort of patients with IPF...
  24. ncbi Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction
    Huseyin Uyarel
    Department of Cardiology, Balikesir University, School of Medicine, Cagis Campus, Balikesir, Turkey
    Coron Artery Dis 22:138-44. 2011
    ..Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI)...
  25. ncbi Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure
    Jaewon Oh
    Cardiology Division, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Seoul, Korea
    J Card Fail 15:517-22. 2009
    ..However, the relation between RDW and echocardiographic parameters in acute heart failure (AHF) has not been studied...
  26. ncbi The diagnostic criteria for iron deficiency in infants should be reevaluated
    Magnus Domellöf
    Department of Clinical Sciences, Pediatrics, Umea University, Sweden
    J Nutr 132:3680-6. 2002
    ..Hb, MCV and ZPP at 6 mo as well as growth variables predicted the Hb response at 6-9 mo, but ferritin and TfR at 6 mo did not. We conclude that there is need for a reevaluation of the definitions of ID and IDA in infants...
  27. ncbi The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons
    Chul Won Choi
    Division of Oncology Hematology, Department of Internal Medicine, Korea University Medical Center, Seoul, South Korea
    Ann Hematol 84:358-61. 2005
    ..The value is lower than the previous value established for hospitalized and anemic older adults...
  28. ncbi Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia
    Roosy Aulakh
    Department of Pediatrics, Christian Medical College and Hospital, Ludhiana, Punjab, India
    Indian J Pediatr 76:265-8. 2009
    ..To study the utility of red cell distribution width (RDW) in the diagnosis of iron deficiency among children with microcytic hypochromic anemia...
  29. ncbi Erythrocyte changes in preeclampsia: relationship between maternal and cord blood erythrocyte damage
    Cristina Catarino
    Faculdade Farmácia, Universidade Porto, Portugal
    J Perinat Med 37:19-27. 2009
    ..Our data show similarities between UCB and maternal RBC changes, as suggested by the correlations of markers of RBC damage...
  30. ncbi Renal function is independently associated with red cell distribution width in kidney transplant recipients: a potential new auxiliary parameter for the clinical evaluation of patients with chronic kidney disease
    Akos Ujszaszi
    Institute of Pathophysiology, Semmelweis University, Budapest, Hungary
    Br J Haematol 161:715-25. 2013
    ..Lower eGFR is associated with higher RDW, independent of comorbidity, iron deficiency, inflammation and nutritional status in kidney transplant recipients...
  31. ncbi Fetal hemorheology in normal pregnancy and severe preeclampsia
    L Heilmann
    Department Obstetrics Gynecology, Clinica Obstetric Gynecology, City Hospital, Russelsheim, Germany
    Clin Hemorheol Microcirc 32:183-90. 2005
    ..9%. An elevated red cell aggregation was found in 2.8% (stasis) and 4.8% (low flow state), respectively. We conclude that in fetal blood the higher hematocrit and the presence of larger red cells do not cause impaired fetal hemorheology...
  32. ncbi Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure
    Nay Aung
    University College London Hospital, London, UK
    Int J Cardiol 168:1997-2002. 2013
    ..We sought to determine the survival implications of temporal changes in RDW and evolving ID in patients with CHF...
  33. ncbi Red cell distribution width in migraine
    A Celikbilek
    Department of Neurology, Bozok University, Yozgat, Turkey
    Int J Lab Hematol 35:620-8. 2013
    ..This study was undertaken to assess the interrelationship between RDW and migraine...
  34. ncbi [Impact of red cell distribution width on outcome of 16 681 patients with chronic systolic heart failure]
    Sheng Bo Yu
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Xin Xue Guan Bing Za Zhi 40:237-42. 2012
    ..To determinate the prognostic value of red cell distribution width (RDW) and the relationships between RDW and clinical characteristics in patients with chronic heart failure (CHF)...
  35. ncbi Red cell distribution width is associated with physical inactivity and heart failure, independent of established risk factors, inflammation or iron metabolism; the EPIC-Norfolk study
    Mireille E Emans
    Department of Cardiology, University Medical Centre, Utrecht, The Netherlands Electronic address
    Int J Cardiol 168:3550-5. 2013
    ..We examined in a healthy population (1) whether this association is independent of cardiovascular risk factors and iron metabolism and (2) whether RDW associates with physical activity...
  36. ncbi The relationship between red blood cell distribution width and the clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up
    Mehmet Gul
    Cardiology Department, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Turkey
    Coron Artery Dis 23:330-6. 2012
    ..Red blood cell distribution width (RDW), a marker of variation in the size of the circulating red blood cells, was evaluated in patients with non-ST elevation myocardial infarction (NSTEMI) and unstable angina pectoris (UAP)...
  37. ncbi Relationship between the red cell distribution width and the one-year outcomes in Chinese patients with stable angina pectoris
    Hairong Ren
    Department of Cardiology, Xuanwu Hospital, Capital Medical University, China
    Intern Med 52:1769-74. 2013
    ..This study was undertaken to determine the relationship between the red cell distribution width (RDW) and the one year outcomes in Chinese patients with stable angina pectoris...
  38. ncbi Altered red blood cell distribution width in overweight adolescents and its association with markers of inflammation
    B Fujita
    Clinic of Internal Medicine I, Friedrich Schiller University, Jena, Germany
    Pediatr Obes 8:385-91. 2013
    ..This analysis aimed to investigate the relationship between RDW and obesity in adolescents and in an animal model of diet-induced obesity (DIO)...
  39. ncbi Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center
    Feng Lian Ma
    Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Chin Med J (Engl) 126:1053-7. 2013
    ..The aim of the present study was prospectively evaluate the severity of coronary artery disease (CAD) and RDW in a large Chinese cohort...
  40. ncbi Red blood cell distribution and survival in patients with chronic obstructive pulmonary disease
    Ekrem Cengiz Seyhan
    Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey
    COPD 10:416-24. 2013
    ..It is unknown whether RDW is associated with mortality in COPD patients...
  41. ncbi Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism
    Ali Zorlu
    Department of Cardiology, Cumhuriyet University Medical School, Sivas, Turkey
    Am J Cardiol 109:128-34. 2012
    ..In conclusion, high RDW was associated with worse hemodynamic parameters, and RDW seems to aid in the risk stratification of patients with acute PE...
  42. ncbi Iron deficiency and erythropoiesis: new diagnostic approaches
    Carlo Brugnara
    Children s Hospital Boston, Department of Laboratory Medicine, 300 Longwood Ave, Boston, MA 02115, USA
    Clin Chem 49:1573-8. 2003
    ..The combination of hematologic markers such as reticulocyte hemoglobin content, which decreases with iron deficiency, and R/F ratio may allow for a more precise classification of anemias...
  43. ncbi Mature erythrocyte indices: new markers of iron availability
    Christophe Bovy
    Haematologica 90:549-51. 2005
    This study was aimed at evaluating mature erythrocyte indices as new markers of iron status...
  44. ncbi Preparation and in vitro evaluation of carrier erythrocytes for RES-targeted delivery of interferon-alpha 2b
    M Hamidi
    Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, P O Box 71345 1583, Shiraz, Iran
    Int J Pharm 341:125-33. 2007
    ..All the tested in vitro characteristics showed significant, sometimes notable changes upon drug loading procedure, both with and without the drug...
  45. ncbi Erythrocyte mean corpuscular volume as a surrogate marker for 6-thioguanine nucleotide concentration monitoring in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine
    Carlton W Thomas
    Division of Gastroenterology and Hepatology, Division of Clinical Pharmacology, and Section of Biostatistics, Mayo Clinic, Rochester, MN 55905, U S A
    Inflamm Bowel Dis 9:237-45. 2003
    ..Measurement of mean corpuscular volume is a simple and inexpensive alternative to measurement of 6-thioguanine nucleotide concentrations in patients treated with azathioprine or 6-mercaptopurine...
  46. ncbi Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the beta-thalassaemia minor from iron deficiency in Palestinian population
    M Sirdah
    Biology Department, Al Azhar University, Gaza, Palestine
    Int J Lab Hematol 30:324-330. 2008
    ....
  47. ncbi Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Int Heart J 50:301-12. 2009
    ..001). In conclusion, elevated BNP levels are independently associated with higher RDW in patients with CAD. Neurohumoral activation may be a mechanistic link between increased RDW and adverse clinical outcomes in this population...
  48. ncbi Iron status at 1 and 6 years versus developmental scores at 6 years in a well-nourished affluent population
    B S Gunnarsson
    Unit for Nutrition Research, Landspitali University Hospital and Department of Food Science and Nutrition, University of Iceland, IS 101, Reykjavik, Iceland
    Acta Paediatr 96:391-5. 2007
    ..To examine the association between iron status at 1 and 6 years with development at 6 years...
  49. ncbi Association of erythrocyte indices with glycated haemoglobin in pre-menopausal women
    M Koga
    Department of Internal Medicine, Kinki Central Hospital, Itami, Japan
    Diabet Med 24:843-7. 2007
    Although HbA(1c) is known to be affected by the lifespan of erythrocytes, any association of erythrocyte indices with HbA(1c) in subjects without anaemia is poorly understood...
  50. ncbi Can patient characteristics predict the outcome of endoscopic evaluation of iron deficiency anemia: a multiple logistic regression analysis
    Gabriele Capurso
    Digestive and Liver Disease Unit, 2nd School of Medicine, Department of Public Health Science University La Sapienza, Rome, Italy
    Gastrointest Endosc 59:766-71. 2004
    ..The purpose of this study was to identify clinical and biochemical variables that predict the outcome of upper/lower endoscopy in outpatients with iron deficiency anemia and to determine which endoscopic procedure should be performed first...
  51. pmc Opportunistic screening for iron-deficiency in 6-36 month old children presenting to the Paediatric Emergency Department
    Martin V Pusic
    Dept of Pediatrics, University of B C, Vancouver, BC, Canada
    BMC Pediatr 5:42. 2005
    ..This study aims to determine the prevalence of a low Mean Cell Volume (MCV) in children having a CBC performed during a PED visit and whether physicians acted upon the abnormal value...
  52. ncbi Does the mean corpuscular volume help physicians evaluate hospitalized patients with anemia?
    S J Seward
    Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts
    J Gen Intern Med 5:187-91. 1990
    ..In this study the MCV did not provide sufficient diagnostic accuracy to be a useful criterion for the selection of more definitive tests in the evaluation of anemia in hospitalized patients...
  53. ncbi The Advia 120 red blood cells and reticulocyte indices are useful in diagnosis of iron-deficiency anemia
    Sanna Kotisaari
    Department of Clinical Chemistry and Hematology, Kuopio University Hospital, Finland
    Eur J Haematol 68:150-6. 2002
    ..Nevertheless, the advanced RBC and reticulocyte indices may prove to be useful tools in the evaluation of iron status and diagnosis of iron-deficiency anemia...
  54. ncbi Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms
    B Annibale
    Digestive and Liver Disease Unit, II Clinica Medica, Policlinico Umberto I, Universita La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    Am J Med 111:439-45. 2001
    ..CONCLUSION: Gastrointestinal diseases that do not usually cause bleeding are frequently associated with iron deficiency anemia in patients without gastrointestinal symptom or other potential causes of gastrointestinal bleeding...
  55. ncbi Erythrocyte indices for discriminating thalassaemic and non-thalassaemic microcytosis in Indians
    J Kotwal
    Department of Haematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Natl Med J India 12:266-7. 1999
    ..CONCLUSION: In countries with a high prevalence of iron deficiency, cut-off values for red cell indices should be recalculated using ROC curves...
  56. pmc Relationship between alcohol drinking and aspartate aminotransferase:alanine aminotransferase (AST:ALT) ratio, mean corpuscular volume (MCV), gamma-glutamyl transpeptidase (GGT), and apolipoprotein A1 and B in the U.S. population
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, and Clarian Digestive Disease Center, Indiana University School of Medicine, and Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202 5124, USA
    J Stud Alcohol Drugs 71:249-52. 2010
    ..We examined the relationship between alcohol drinking and the levels of these markers in a national population-based study composed primarily of lighter drinkers...
  57. ncbi Prognostic implication of macrocytosis on adverse outcomes after coronary intervention
    Masahiro Myojo
    Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo 113 8655, Japan
    Atherosclerosis 221:148-53. 2012
    ..The aim of this study was to perform prognostic risk stratification of patients after PCI based on the presence or absence of macrocytosis...
  58. ncbi Treatment of iron deficiency anemia with intravenous iron preparations
    Saadet Akarsu
    Department of Pediatrics, Medical Faculty of Firat University, Elazig, Turkey
    Acta Haematol 116:51-7. 2006
    ..We aimed to determine the effects of intravenous iron therapy on blood parameters in pediatric patients who do not tolerate oral iron therapy for any reason...
  59. ncbi Red cell distribution width in the diagnosis of iron deficiency anemia
    D Viswanath
    Department of Pediatrics, M.S. Ramaiah Medical Teaching Hospital, Bangalore, India
    Indian J Pediatr 68:1117-9. 2001
    ..CONCLUSION: In the diagnosis of mild and moderate iron deficiency anemia, RDW had a higher sensitivity than PS. Red cell morphology, Hb, PCV and RDW showed significant improvement after iron-therapy...
  60. ncbi Hypochromic red blood cells in low-risk myelodysplastic syndromes: effects of treatment with hemopoietic growth factors
    Therese Ljung
    Department of Medicine, Division of Hematology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Haematologica 89:1446-53. 2004
    ..The present study was designed to assess whether functional iron deficiency may develop in MDS patients receiving these treatments...
  61. ncbi Subcutaneous administration of darbepoetin alfa effectively maintains hemoglobin concentrations at extended dose intervals in peritoneal dialysis patients
    Yu Wei Fang
    Division of Nephrology, Department of Internal Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Perit Dial Int 29:199-203. 2009
    ..The purpose of this single-center single-arm study was to determine whether darbepoetin alfa, when administered at extended dose intervals, is as effective as rHuEPO for the treatment of renal anemia in patients on peritoneal dialysis...
  62. pmc Detecting iron deficiency in anemic patients with concomitant medical problems
    A M Kis
    University of Wisconsin Department of Medicine, Department of Veterans Affairs Geriatric Research, Education, and Clinical Center, Madison, USA
    J Gen Intern Med 13:455-61. 1998
    ..This is higher than the ferritin level of < or =50 microg/L cited in standard textbooks as evidence of iron deficiency in patients with inflammation, infection, or malignancy...
  63. ncbi Predictors of endoscopic and laboratory evaluation of iron deficiency anemia in hospitalized patients
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    South Med J 100:976-84. 2007
    ..Many hospitalized anemic patients do not undergo appropriate evaluation. We hypothesized that specific clinical variables were likely to be important in triggering evaluation for iron deficiency anemia...
  64. pmc Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
    Ken Sin Lo
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada
    Hum Genet 129:307-17. 2011
    ..Our results show similarities but also differences in the genetic regulation of hematological traits in European- and African-derived populations, and highlight the role of natural selection in shaping these differences...
  65. ncbi Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoh
    B Hock
    Psychiatric Clinic of Ludwig Maximilian University, Munich, Germany
    Addiction 100:1477-86. 2005
    ....
  66. ncbi Mean red cell volume as a correlate of blood pressure
    D S Sharp
    Honolulu Epidemiology Research Unit, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Honolulu, Hawaii, USA
    Circulation 93:1677-84. 1996
    ..Epidemiological studies show no relation or higher MCVs. In the present study of elderly men (71 to 93 years of age) of the Honolulu Heart Program, elements of both findings are confirmed...
  67. ncbi Analysis of red cell parameters on the Sysmex XE 2100 and ADVIA 120 in iron deficiency and in uraemic chronic disease
    O David
    Department of Clinical Pathology, Regina Margherita S Anna Hospital, Turin, Italy
    Scand J Clin Lab Invest 66:113-20. 2006
    ..The aim of this study was to evaluate the extent to which the red cell parameters, RBC-Y and RET-Y, provided by Sysmex XE 2100, correlate with HYPO and CHr...
  68. ncbi Exertional Rhabdomyolysis during a 246-km continuous running race
    Katerina P Skenderi
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
    Med Sci Sports Exerc 38:1054-7. 2006
    ..To evaluate the effect of continuous, moderate-intensity ultra-endurance running exercise on skeletal muscle and hepatic damage, as indicated by serum enzyme activity measured immediately following the race...
  69. pmc Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1
    M M Santos
    Departments of Immunology, Pathology, and Internal Medicine, University Hospital Utrecht, Utrecht, The Netherlands
    Am J Pathol 157:1883-92. 2000
    ..Mice deficient in ss2m and Rag1 thus offer a new experimental model of iron-related cardiomyopathy...
  70. ncbi Comparison of hematologic data in world elite junior speed skaters and in non-athletic juniors
    A Mayr
    Laboratory of Clinical Pathology, Hospital of Brunico, Italy, and Faculty of Health Sciences, University Maastricht, The Netherlands
    Int J Sports Med 27:283-8. 2006
    ..In junior athletes we did not find an iron overload as described in some adult athletes...
  71. ncbi Hematological parameters in tench Tinca tinca after short term exposure to lead
    Syed Lal Shah
    Pakistan Science Foundation, Islamabad
    J Appl Toxicol 26:223-8. 2006
    ....
  72. ncbi Hand strike-induced hemolysis and adaptations in iron metabolism in Basque ball players
    Alfredo Córdova Martínez
    Department of Physiology and Biochemistry, School of Physiotherapy, University of Valladolid, Soria, Spain
    Ann Nutr Metab 50:206-13. 2006
    ..Basque ball players (BBPs) make repeated hand strikes to the ball which involves continuous mechanical trauma...
  73. ncbi Allopurinol prevents erythrocyte deformability impairing but not the hematological alterations after limb ischemia-reperfusion in rats
    Norbert Nemeth
    Department of Operative Techniques and Surgical Research, Medical and Health Science Center, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
    J Invest Surg 19:47-56. 2006
    ..In summary, short-term ischemia and reperfusion induced lower red blood cell deformability in the early postoperative period, which could be prevented by allopurinol pretreatment...
  74. ncbi Shortcomings in infant iron deficiency screening methods
    Paul G Biondich
    Children s Health Services Research, Indianapolis, Indiana, USA
    Pediatrics 117:290-4. 2006
    ..Screening for iron deficiency anemia is a well-established practice in pediatrics, but numerous challenges surrounding current recommendations raise questions about the effectiveness of this strategy...
  75. ncbi Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes
    Jon Peter Wehrlin
    Swiss Federal Institute of Sports, Section for Elite Sport, 2532 Magglingen, Switzerland
    J Appl Physiol (1985) 100:1938-45. 2006
    ..1,080+/-98 s; P<0.01) from pre- to postaltitude. Living at 2,500 m and training at lower altitudes for 24 days increases Hbmass and RCV. These changes may contribute to enhance performance of elite endurance athletes...
  76. ncbi Development of parameters influencing blood oxygen carrying capacity in the welcome swallow and fairy martin
    Prudence Simmons
    Wildlife Ecology Research Group, School of Biological Sciences, Monash University, Victoria 3800, Australia
    Comp Biochem Physiol A Mol Integr Physiol 143:459-68. 2006
    ..3- to 1.5-fold. Possible reasons for the apparent differences in the timing of O2Cap increase between rapidly and slowly growing altricial species and among MOR species are discussed...
  77. ncbi Specific activities of poetam preparation (superlow-doses of antibodies to erythropoietin) and recombinant erythropoietin
    A M Dygai
    Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences
    Bull Exp Biol Med 142:320-3. 2006
    ..The effect of Recormon manifested immediately after injection, while the effect of Poetam was somewhat delayed, but more lasting (due to activation of host erythropoietin system)...
  78. ncbi Blood viscosity and its relationship to iron deficiency, symptoms, and exercise capacity in adults with cyanotic congenital heart disease
    Craig S Broberg
    Adult Congenital Heart Centre, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, England
    J Am Coll Cardiol 48:356-65. 2006
    ..This study sought to determine the relationship between blood viscosity and iron deficiency and their impact on symptoms and exercise function in adults with cyanotic congenital heart disease...
  79. doi Restless leg syndrome: iron important
    Margaret A Fitzgerald
    Fitzgerald Health Education Associates, Inc, North Andover, MA, USA
    Nurse Pract 33:7-9. 2008
  80. ncbi Hematological parameters and anaerobic threshold in Brazilian soccer players throughout a training program
    A S R Silva
    Department of Physical Education, Bioscience Institute, University of Sao Paulo State Unesp, Rio Claro, Sao Paulo, Brazil
    Int J Lab Hematol 30:158-66. 2008
    ..Furthermore, we did not observe any correlation between the anaerobic threshold and the hematological parameters...
  81. ncbi Iron deficiency anemia, beta-thalassemia minor, and anemia of chronic disease: a morphologic reappraisal
    Alexandra M Harrington
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Clin Pathol 129:466-71. 2008
    ....
  82. ncbi Comparison of iron and hematological indices in Giardia lamblia infection before and after treatment in 102 children in Ahwaz, Iran
    Seyed Mehdi Monajemzadeh
    Department of Pediatrics, Golestan Hospital, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
    Med Sci Monit 14:CR19-23. 2008
    ..The aim of this study was to evaluate the effects of giardiasis treatment on hematological indices in children in the Khuzestan area by comparing these indices before and after treatment with metronidazole...
  83. ncbi Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice
    Michael Foller
    Department of Physiology, University of Tuebingen, Gmelinstr 5, 72076 Tubingen, Germany
    Pflugers Arch 455:939-49. 2008
    ..The experiments reveal that PDK1 deficiency is associated with decreased Ca2+ entry into erythrocytes and thus with blunted eryptotic effects of oxidative stress, osmotic shock and Cl- removal...
  84. ncbi Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats
    Andrzej Starek
    Department of Biochemical Toxicology, Medical College, Jagiellonian University, Krakow, Poland
    Arch Toxicol 82:125-36. 2008
    ..On the contrary, tolerance to IPE- and BE-induced hemolysis in rats exposed to these compounds was prompted...
  85. ncbi Reticulocyte hemoglobin content for the diagnosis of iron deficiency
    Maria Elena Mateos
    Department of Pediatrics, University Hospital Reina Sofia, Cordoba, Spain
    J Pediatr Hematol Oncol 30:539-42. 2008
    ..Therefore, we conclude that the hematologic parameter CHr constitutes a valuable screening tool for the identification of ID with or without anemia in childhood...
  86. ncbi Changes of hematological parameters in Prochilodus lineatus (Pisces, Prochilodontidae) exposed to sublethal concentration of cypermethrin
    M J Parma
    Instituto Nacional de Limnología INALI CONICET UNL, Jose Macia 1933, 3016 Santo Tome, Santa Fe, Argentina
    J Environ Biol 28:147-9. 2007
    ..These reports indicate that hematological parameters, may be useful as a diagnostic test for cypermethrin exposure in aquatic organisms...
  87. ncbi Effect of oral tetracycline on iron absorption from iron(III)-hydroxide polymaltose complex in patients with iron deficiency anemia / a single-centre randomized controlled isotope study
    Maria A Potgieter
    Farmovs Parexel, Bloemfontein, South Africa
    Arzneimittelforschung 57:376-84. 2007
    ..No differences between the two treatment groups with regard to the erythrocyte iron uptake were found, and thus IPC can be used with tetracycline, if necessary...
  88. ncbi Effect of petroleum products inhalation on some haematological indices of fuel attendants in Calabar metropolis, Nigeria
    A M Okoro
    Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
    Niger J Physiol Sci 21:71-5. 2006
    ..These results indicate that the petroleum fumes cause a reduction in haematological indices which worsens with prolonged exposure...
  89. ncbi The effect of repeated blood donations on the iron status of Iranian blood donors attending the Iranian blood transfusion organization
    Mahmoud Djalali
    Tehran University of Medical Sciences, Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research Tehran, Iran
    Int J Vitam Nutr Res 76:132-7. 2006
    ....
  90. ncbi The relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected with Fasciola hepatica
    S Lotfollahzadeh
    Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    J Helminthol 82:85-8. 2008
    ..The increased activities of serum enzymes indicated chronic hepatic and bile duct injuries associated with chronic infection with F. hepatica...
  91. ncbi Iron deficiency in the acute-phase reaction after open aortic surgery
    J V Solis
    Angiology and Vascular Surgery Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Vasc Endovascular Surg 40:392-8. 2006
    ....
  92. ncbi The influence of dietary vitamin C and E supplementation on the physiological response of pirarucu, Arapaima gigas, in net culture
    Glauber Cruz de Menezes
    Department of Aquaculture, INPA Amazonian National Research Institute, Av Andre Araujo, 2936, P O Box 478, Manaus, AM 69069 001, Brazil
    Comp Biochem Physiol A Mol Integr Physiol 145:274-9. 2006
    ..gigas immunological status. Red blood cell indices and immune system indicators showed no synergistic effect between the vitamins after supplementing the A. gigas diet with alpha-T+AA...
  93. ncbi The relationship between haematological indices, serum gamma-glutamyl transferase and glutamate dehydrogenase, visual hepatic damage and worm burden in cattle infected with Fasciola gigantica
    E C Molina
    College of Veterinary Medicine, University of Southern Mindanao, Kabacan, Cotabato 9407, Philippines
    J Helminthol 80:277-9. 2006
    ..Red blood cell counts and packed cell volume were significantly inversely related to worm burden, but animals compensated for reduced numbers of red blood cells by increasing red cell haemoglobin content...
  94. ncbi [Anaemia, iron index status and acute phase proteins in malaria (Abidjan, Côte d'Ivoire)]
    H Ahiboh
    Departement de Biochimie, Institut Pasteur de Côte d Ivoire, BP 490 Abidjan 01, Cote d Ivoire
    Bull Soc Pathol Exot 101:25-8. 2008
    ..When parasitaemia is low anaemia gets a haemolytic feature. When parasitaemia is high, anaemia gets haemolytic and inflammatory features. Anaemia occurs more often with a good iron index status...
  95. ncbi Incidence of high erythrocyte count in infants and young children with iron deficiency anemia: re-evaluation of an old parameter
    Deniz Aslan
    Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    J Pediatr Hematol Oncol 25:303-6. 2003
    ..0 x 106/microL) in infants and young children with iron deficiency anemia and to document the differences in hematologic parameters at diagnosis and during iron therapy in IDA patients with and without a high erythrocyte count...
  96. ncbi Serum transferrin receptor in the evaluation of the iron status in elderly hospitalized patients with anemia
    Etienne Joosten
    Division of Geriatric Medicine, Department of Physiopathology, University Hospitals K U Leuven, Belgium
    Am J Hematol 69:1-6. 2002
    ..We conclude that serum ferritin is a more sensitive and specific parameter than the sTfR assay to predict the bone marrow iron status in an elderly anemic population...
  97. ncbi Iron status and dietary iron intake of adolescents from a rural community in Sabah, Malaysia
    Leng Huat Foo
    Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006
    Asia Pac J Clin Nutr 13:48-55. 2004
    ..Priority should therefore be given to the eradication of iron deficiency in adolescents from low-income areas by dietary modification and micronutrient supplementation amongst female adolescents...
  98. ncbi Tolerance and efficacy of intravenous iron saccharate for iron deficiency anemia in children and adolescents receiving long-term parenteral nutrition
    L Michaud
    Division of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine and Children s Hospital, Lille University, Lille, France
    Clin Nutr 21:403-7. 2002
    ....
  99. ncbi Erythrocyte protoporphyrin or hemoglobin: which is a better screening test for iron deficiency in children and women?
    Zuguo Mei
    Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Clin Nutr 77:1229-33. 2003
    ..Hemoglobin and erythrocyte protoporphyrin (EP) tests are commonly used to screen for iron deficiency. However, little research has been done to systematically evaluate the sensitivity and specificity of these 2 tests...
  100. ncbi Time and temperature dependant changes in red blood cell analytes used for testing recombinant erythropoietin abuse in sports
    Neil Robinson
    Laboratoire Suisse d Analyse du Dopage, Institut Universitaire de Medecine Legale, Lausanne, Switzerland
    Clin Lab 50:317-23. 2004
    ..These recommendations should ideally also be applied to the all the blood controls compulsory for the medical follow up, otherwise unexplainable values could be misinterpreted and could for instance lead to a period of incapacity...
  101. ncbi Immunological and hematological effects observed in B6C3F1 mice exposed to JP-8 jet fuel for 14 days
    D Keil
    National Institute of Occupational Safety and Health, Morgantown, West Virginia, and Department of Health Professions, Medical University of South Carolina, Charleston, South Carolina, USA
    J Toxicol Environ Health A 67:1109-29. 2004
    ....

Research Grants38

  1. Painless Microsampling System for Total Hemoglobin and Hematocrit Monitoring
    Brian Sullivan; Fiscal Year: 2007
    ..Its ease of use will also make it attractive for nursing homes, home health care, and other out-patient point-of-care applications. [unreadable] [unreadable] [unreadable]..
  2. RBC Ion Transporters as Hemoglobinopathy Risk Modifiers
    Seth Alper; Fiscal Year: 2009
    ..The proposed experiments will increase understanding of sickle cell disease and thalassemia by providing mouse models for genetic tests of new drug therapies under development for near-term clinical testing. ..
  3. Adducin and the Membrane Skeleton
    LUANNE PETERS; Fiscal Year: 2007
    ..Follow up studies will include electrocardiology and echocardiology. ..
  4. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006
    ..5 isoform in the structure and assembly of the sarcoplasmic reticulum by an in vivo developmental study. ..
  5. Mouse Models for Heart, Lung and Blood Disease
    LUANNE PETERS; Fiscal Year: 2007
    ..New mouse models will be cryo-preserved in order to maintain their availability. Provision are likewise to maintain all JAX PGA resources beyond the PGA program. ..
  6. GENETIC INTERACTIONS IN RED CELL MEMBRANE DISEASE
    LUANNE PETERS; Fiscal Year: 2003
    ....
  7. ORGANELLE MEMBRANES IN PLATELET STORAGE POOL DISEASE
    LUANNE PETERS; Fiscal Year: 2009
    ..Lung fibrosis typically leads to death in the 4th to 5th decades. This study is designed to identify the underlying genetic causes of HPS, which will provide avenues of research for potential therapies. ..
  8. Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
    Mary E Fabry; Fiscal Year: 2010
    ..These observations may be applicable to patient interventions. ..
  9. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2009
    ..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
  10. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  11. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. [unreadable] [unreadable]..
  12. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  13. Therapeutic Modulation of COX-2-induced Immunosuppression in Metastatic RCC
    Brian Rini; Fiscal Year: 2008
    ..This project will have broad implications for the immunoregulation of cancer and how expression and modulation of COX-2 expression influences the immune response to cancer. [unreadable] [unreadable] [unreadable]..
  14. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2007
    ..abstract_text> ..
  15. FUNCTIONAL SIGNIFICANCE OF EARLY IRON DEFICIENCY
    Betsy Lozoff; Fiscal Year: 2008
    ..abstract_text> ..
  16. Attentional Dysfunction in Children with Phenylketonuria
    Georgianne Arnold; Fiscal Year: 2008
    ....
  17. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
    ..abstract_text> ..
  18. Genetic Determinants of Erythrocyte Hydration
    Carlo Brugnara; Fiscal Year: 2009
    ..abstract_text> ..
  19. Taking Community Action Against Pain
    MANNEY REID; Fiscal Year: 2008
    ..g., senior centers). [unreadable] [unreadable] [unreadable]..
  20. PATHOGENESIS OF SICKLE CELL GLOMERULOPATHY
    Antonio Guasch; Fiscal Year: 2001
    ..They hope that this information will help design trials that target patients at higher risk and find new treatments for this disease. ..
  21. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2004
    ..abstract_text> ..
  22. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
  23. SICKLING MECHANISMS AND RED CELL MEMBRANES
    ROBERT BOOKCHIN; Fiscal Year: 2002
    ..Once characterized, these will serve investigations within the above three aims. ..
  24. FACSVantage SE Sorting Flow Cytometer
    Jane Barker; Fiscal Year: 2002
    ..Funds are requested to purchase the FACSVantage SE and the optional equipment for TJL's Flow Cytometry Service. This will provide a cost-effective way to fill an urgent need of TJL's principal investigators. ..
  25. Early Glomerular Changes in Diabetic African-Americans
    Antonio Guasch; Fiscal Year: 2004
    ..This may lead to therapies that could be started very early on in diabetic patients targeted at preventing the development of kidney complications. ..
  26. GENETIC ENGINEERING OF CELLS FROM ANEMIC ANIMALS
    Jane Barker; Fiscal Year: 2003
    ..abstract_text> ..
  27. MAGNESIUM AND SICKLE CELL DISEASE
    Carlo Brugnara; Fiscal Year: 2005
    ..These aims are consistent with the long-term goals of the applicant, who is focused on the study on membrane transport and volume regulation and the continued development of new therapies for sickle cell disease. ..
  28. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
  29. Thyrocytes Express Inflammatory Mediators
    Andrew Gianoukakis; Fiscal Year: 2006
    ..The candidate will develop the scientific knowledge base, problem solving abilities, and technical skills which will allow him to develop into a independent physician/scientiist. ..
  30. Effects of Glycosylation on RBC Ca2+ Pump in Diabetes
    ROBERT BOOKCHIN; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. China MACS: An Exploratory Study
    Shenghan Lai; Fiscal Year: 2006
    ..The study could have major impact on a HIV-related biological, behavioral, and clinical research that extends beyond China to include all populations at risk for HIV infection. [unreadable] [unreadable] [unreadable]..
  32. INDICES OF BIOTIN NUTRITION
    Donald Mock; Fiscal Year: 2001
    ..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
  33. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  34. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  35. Implementing a Cognitive/Exercise Therapy for Back Pain in The Community Setting
    MANNEY REID; Fiscal Year: 2008
    ..Elaine Wethington), and geriatric physical therapy and instructional development and evaluation (Dr.Katherine Beissner), and are highly qualified to conduct the planned research. ..
  36. Maternal flu infection and brain development in primates
    Christopher L Coe; Fiscal Year: 2010
    ....
  37. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..