thrombin time

Summary

Summary: Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.

Top Publications

  1. ncbi Preparation and anticoagulation activity of sodium cellulose sulfate
    Zhao Mei Wang
    Research Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China
    Int J Biol Macromol 41:376-82. 2007
  2. ncbi Antifactor Xa activity correlates to thrombin generation time, platelet contractile force and clot elastic modulus following ex vivo enoxaparin exposure in patients with and without renal dysfunction
    D F Brophy
    Department of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia, USA
    J Thromb Haemost 2:1299-304. 2004
  3. ncbi [Treatment of chronic idiopathic thrombocytopenic purpura with small dose heparin: a report of 12 cases]
    Min fang Wang
    Department of Hematology, Pingdingshan First People s Hospital, Pingdingshan 467000, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 10:251-2. 2002
  4. ncbi Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model
    Po Yuan Tseng
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, 30320, USA
    Biomaterials 27:2637-50. 2006
  5. ncbi Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    Nick R Bijsterveld
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 106:2550-4. 2002
  6. ncbi A novel fibrinogen Bbeta chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia
    Xiucai Xu
    The Center Laboratory of Anhui Provincial Hospital, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
    Thromb Haemost 95:931-5. 2006
  7. ncbi Anticoagulant from Taraxacum platycarpum
    Soo In Yun
    Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Korea
    Biosci Biotechnol Biochem 66:1859-64. 2002
  8. ncbi Combinations of low doses of unfractionated heparin and of low-molecular-weight heparin prevent experimental venous thrombosis
    Guareide Carelli
    Faculdade de Medicina and Instituto de Biociências de Botucatu, UNESP, Botucatu, Brazil
    Pathophysiol Haemost Thromb 34:263-8. 2005
  9. ncbi Investigations on blood coagulation in the green iguana (Iguana iguana)
    S Kubalek
    Clinic for Small Animals, School of Veterinary Medicine, Hanover, Germany
    J Vet Med A Physiol Pathol Clin Med 49:210-6. 2002
  10. ncbi The antithrombotic effect of borneol related to its anticoagulant property
    Yan Hong Li
    Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    Am J Chin Med 36:719-27. 2008

Research Grants

  1. Symphony Multiplex Peptide Synthesizer w/ VISION Workstn
    Kenneth Mann; Fiscal Year: 2004
  2. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2007
  3. HEMOSTASIS AND THROMBOSIS PROGRAM FOR ACADEMIC TRAINEES
    Kenneth Mann; Fiscal Year: 2007
  4. Transfusion Medicine/Hemostasis Clinical Research Network
    Ronald Strauss; Fiscal Year: 2007
  5. Surface Dependent Reactions in Thrombosis and Thrombolysis
    Kenneth Mann; Fiscal Year: 2007
  6. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2003
  7. PE BIOSYSTEMS VOYAGER DE MALDI-TOF
    Kenneth Mann; Fiscal Year: 2001

Detail Information

Publications224 found, 100 shown here

  1. ncbi Preparation and anticoagulation activity of sodium cellulose sulfate
    Zhao Mei Wang
    Research Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China
    Int J Biol Macromol 41:376-82. 2007
    ..higher anticoagulation activity based on activated partial thromboplastin time (APTT) assay and prolonged the thrombin time (TT) to a lesser extent than heparin. No effect was detected on the prothrombin time (PT)...
  2. ncbi Antifactor Xa activity correlates to thrombin generation time, platelet contractile force and clot elastic modulus following ex vivo enoxaparin exposure in patients with and without renal dysfunction
    D F Brophy
    Department of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia, USA
    J Thromb Haemost 2:1299-304. 2004
    ..These results suggest that patients with renal dysfunction have a greater pharmacodynamic response to LMWH, independent of the pharmacokinetics of LMWH...
  3. ncbi [Treatment of chronic idiopathic thrombocytopenic purpura with small dose heparin: a report of 12 cases]
    Min fang Wang
    Department of Hematology, Pingdingshan First People s Hospital, Pingdingshan 467000, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 10:251-2. 2002
    ..The curative effects were seen in 8 patients and there were no exacerbation of hemorrhage during the therapy. The results showed that it is effective and safe to use this treatment for CITP...
  4. ncbi Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model
    Po Yuan Tseng
    School of Chemical Engineering, Georgia Institute of Technology, Atlanta, 30320, USA
    Biomaterials 27:2637-50. 2006
    ..These studies are the first to demonstrate the additive effect of surface bound heparin and TM as a combined interactive strategy to limit TF-induced thrombin formation...
  5. ncbi Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    Nick R Bijsterveld
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 106:2550-4. 2002
    ..The aim of this study was to investigate whether recombinant factor VIIa (rFVIIa) could neutralize the anticoagulant effects of subcutaneously administered fondaparinux...
  6. ncbi A novel fibrinogen Bbeta chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia
    Xiucai Xu
    The Center Laboratory of Anhui Provincial Hospital, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
    Thromb Haemost 95:931-5. 2006
    ..The propositus frequently displayed bleeding episodes with a prolonged blood-clotting time (thrombin time > 180 s, activated partial thromboplastin time > 300 s, prothrombin time > 120 s) and had a very low level of ..
  7. ncbi Anticoagulant from Taraxacum platycarpum
    Soo In Yun
    Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Korea
    Biosci Biotechnol Biochem 66:1859-64. 2002
    ..When present at the concentration of 70, 255, and 873 nM, respectively, the protein doubled the thrombin time, prothrombin time, and activated partial thromboplastin time...
  8. ncbi Combinations of low doses of unfractionated heparin and of low-molecular-weight heparin prevent experimental venous thrombosis
    Guareide Carelli
    Faculdade de Medicina and Instituto de Biociências de Botucatu, UNESP, Botucatu, Brazil
    Pathophysiol Haemost Thromb 34:263-8. 2005
    ..Bleeding time, activated partial thromboplastin time, thrombin time (TT), and anti-factor Xa were measured at the beginning and end of the experiment...
  9. ncbi Investigations on blood coagulation in the green iguana (Iguana iguana)
    S Kubalek
    Clinic for Small Animals, School of Veterinary Medicine, Hanover, Germany
    J Vet Med A Physiol Pathol Clin Med 49:210-6. 2002
    The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time, kaolin clotting time (KCT), dilute Russell's viper venom time (DRVVT) and reptilase time, as well as five different plasma fibrinogen assays [..
  10. ncbi The antithrombotic effect of borneol related to its anticoagulant property
    Yan Hong Li
    Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
    Am J Chin Med 36:719-27. 2008
    ..Meanwhile, borneol prolonged the coagulation parameters for prothrombin time (PT) and thrombin time (TT), but did not show any fibrinolytic activity...
  11. ncbi Anticoagulant property of a semi-synthesized sodium beta-1,4-glucan sulfate
    Zhao Mei Wang
    Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou
    Yao Xue Xue Bao 41:323-7. 2006
    ..To investigate the anticoagulant efficacy and mechanism of a semi-synthesized sodium beta-1,4-glucan sulfate (Na-MCS)...
  12. ncbi Anticoagulant effects of repeated subcutaneous injections of high doses of unfractionated heparin in healthy dogs
    R H Mischke
    Clinic for Small Animals, School of Veterinary Medicine, Hannover, Germany
    Am J Vet Res 62:1887-91. 2001
    ..heparin injections to determine amidolytic heparin activity, activated partial thromboplastin time (APTT), thrombin time, antithrombin activity, platelet count, and Hct...
  13. ncbi Comparison of anticoagulation efficacy and clinical safety between imported and domestically manufactured low-molecular-weight heparin during hemodialysis
    Zhi Qiang Liu
    Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 22:942-3. 2002
    ..To compare the anticoagulation efficacy and clinical safety of domestically manufactured and imported low-molecular-weight-heparin during hemodialysis...
  14. ncbi Decreased anticoagulant response to tissue factor pathway inhibitor type 1 in plasmas from patients with lupus anticoagulants
    Sigurd Liestøl
    Department of Haematology, Ulleval University Hospital, Oslo, Norway
    Br J Haematol 136:131-7. 2007
    ..68%, P = 0.007). Our findings support the hypothesis that TFPI anticoagulant activity is inhibited in some patients with LA...
  15. ncbi Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Haemost 94:958-64. 2005
    ..DTIs with a relatively low affinity for thrombin require high plasma concentrations to double the APTT; these higher plasma concentrations, in turn, quench more of the thrombin generated in the PT, thereby more greatly prolonging the PT...
  16. ncbi [Case report. Phenprocoumon (Marcumar, Falithrom) as an unusual reason for coumarin poisoning in a dog]
    G Lutze
    Institut fur Klinische Chemie und Pathobiochemie, Otto von Guericke Universitat Magdeburg
    Dtsch Tierarztl Wochenschr 110:31-3. 2003
    ..a prolonged activated recalcification time (ARCT), prothrombin time (PT) and aPTT with uncharacteristic thrombin time (TT); factor II, VII and X activities were reduced while factor V activity was normal, all of which are ..
  17. ncbi Mechanism for shortening PT and APTT in dogs and rats--effect of fibrinogen on PT and APTT--
    Masaaki Kurata
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 28:439-43. 2003
    ..The increased concentrations of clottable fibrinogen in the test system were confirmed by markedly shortened thrombin time (TT)...
  18. ncbi Monitoring complex formation in the blood-coagulation cascade using aptamer-coated SAW sensors
    T M A Gronewold
    Center of Advanced European Studies and Research, Aptamer Biosensors, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Biosens Bioelectron 20:2044-52. 2005
    ..Binding of heparin activated the formation of the inhibitory complex of antithrombin III with thrombin about 2.7-fold. Binding of the DNA aptamer to exosite II appeared to inhibit heparin binding to exosite I...
  19. ncbi Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora
    T M A Silva
    Laboratório de Glicobiologia, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Natal, Brasil
    Braz J Med Biol Res 38:523-33. 2005
    ....
  20. ncbi Do trichothecenes reduce viability of circulating blood cells and modify haemostasis parameters?
    R Froquet
    Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopole Brest Iroise, 29280 Plouzane, France
    Mycopathologia 156:349-56. 2003
    ..Due to the differences in sensitivities between mature blood cells and haematopoietic progenitors, haematological problems associated with trichothecene intoxication could be attributed to haematopoiesis inhibition...
  21. ncbi The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity
    You Seon Sa
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Korea
    Arch Pharm Res 28:667-74. 2005
    ..It delayed thrombin time (TT), activated partial thromboplastin time (APTT), and prothrombin time (PT) using human plasma...
  22. ncbi The effects of automated plasmapheresis on clinical, haematological, biochemical and coagulation variables in horses
    K Feige
    Equine Clinic, Faculty of Veterinary Medicine, University of Zurich, Winterthurerstr 260, CH 8057 Zurich, Switzerland
    Vet J 169:102-7. 2005
    ..After plasmapheresis, the mean value of the activated partial thromboplastin time and the thrombin time were mildly but significantly increased (P < 0...
  23. ncbi Effects of platelets and platelet-derived material on the activated partial thromboplastin time (Cephotest) coagulation test
    E E Mendelsohn
    Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway
    Scand J Clin Lab Invest 65:321-32. 2005
    ..To perform this test, blood is usually centrifuged to obtain plasma that is almost without erythrocytes and leucocytes and with only a minimal amount of platelets...
  24. ncbi Comparison of unfractioned and low molecular weight heparin for prophylaxis of coagulopathies in 52 horses with colic: a randomised double-blind clinical trial
    K Feige
    Department of Veterinary Internal Medicine, University Animal Hospital, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Equine Vet J 35:506-13. 2003
    ..Unfractioned heparin (UFH) is widely used for prophylaxis of coagulation disorders, especially in colic-affected horses. However, it is accompanied by certain side effects...
  25. ncbi Experimental study on anticoagulant and antiplatelet aggregation activity of a chemically sulfated marine polysaccharide YCP
    Fang Han
    School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China
    Int J Biol Macromol 36:201-7. 2005
    ..sulfated derivates were evaluated by activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and platelet aggregation assay...
  26. ncbi The measurement and application of thrombin generation
    Trevor Baglin
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    Br J Haematol 130:653-61. 2005
    ..Ultimately management studies will be required if the clinical utility of measurement of thrombin generation is to be proven...
  27. ncbi An international survey of current practice in the laboratory assessment of anticoagulant therapy with heparin
    Emmanuel J Favaloro
    Department of Haematology and Royal College of Pathologists of Australasia Quality Assurance Program, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    Pathology 37:234-8. 2005
    ..We conducted a survey of laboratory practice for assessment of heparin anticoagulant therapy by participants of the Royal College of Pathologists of Australasia Quality Assurance Program (RCPA QAP)...
  28. ncbi Depolymerized holothurian glycosaminoglycan (DHG), a novel alternative anticoagulant for hemodialysis, is safe and effective in a dog renal failure model
    Kazuhisa Minamiguchi
    Microbial Chemistry Research Foundation, Institute for Chemotherapy, Numazu, Shizuoka, Japan
    Kidney Int 63:1548-55. 2003
    ..In this study, the anticoagulant and hemorrhagic effects of DHG were investigated on hemodialysis in a dog model of renal failure and compared with those of UFH, LMWH, and nafamostat mesilate (FUT)...
  29. ncbi Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status
    M Sumitra
    Department of Biotechnology, Central Leather Research Institute, Adyar, Chennai, India
    Mol Cell Biochem 224:135-42. 2001
    ..This study shows that the cardioprotection of arjunolic acid pre and post treatment could possibly be due to the protective effect against the damage caused by myocardial necrosis...
  30. ncbi Fucosylated chondroitin sulfate as a new oral antithrombotic agent
    Roberto J C Fonseca
    Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Instituto de Bioquímica Médica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Thromb Haemost 96:822-9. 2006
    ..the plasma anticoagulant activity, as assessed by assays for activated partial thromboplastin time (aPTT) and thrombin time (TT) (about 3- and 5-fold, respectively) and by anti-IIa activity...
  31. ncbi Gender and inter-species influence on coagulation tests of rats and mice
    Cristina Lemini
    Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Apartado Postal 70 297, CP 04510, D F, Mexico
    Thromb Res 120:415-9. 2007
    ..The aim of this work was to standardize blood coagulation screening tests in adult male, female, and ovariectomized (Ovx) Wistar rats and CD1 mice in an effort to evaluate the influence of gender and species differences on haemostasis...
  32. doi Construction and functional evaluation of hirudin derivatives with low bleeding risk
    Chuanling Zhang
    Key Lab of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, P R China
    Thromb Haemost 99:324-30. 2008
    ..were lower than that of HIR as indicated by the values of activated partial thromboplastin time (APTT) and thrombin time (TT). To further assess the safety of these derivatives, bleeding time was measured in a mouse tail-cut model...
  33. ncbi [Study of a glycoprotein from Gastrodia elata: its effects of anticoagulation and antithrombosis]
    Cheng shi Ding
    Institute of Biochencistry and Nicrobiology, Anhui University, Hefei 230039, China
    Zhongguo Zhong Yao Za Zhi 32:1060-4. 2007
    ..To investigate the effects of polysaccharide 2-1 from Gastrodia elata (PGE2-1) on blood coagulation and thrombosis...
  34. ncbi Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity
    Jochen Graff
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, University Hospital, Frankfurt Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Clin Pharmacol 47:1398-407. 2007
    ..Rivaroxaban strongly inhibits platelet-induced thrombin generation, after activation of either platelets or the coagulation pathway, even in the presence of minimal factor Xa inhibition in plasma...
  35. ncbi Citrate anticoagulation and the dynamics of thrombin generation
    K G Mann
    Department of Biochemistry, University of Vermont, Colchester, VT 05446, USA
    J Thromb Haemost 5:2055-61. 2007
    ..Anticoagulation of blood without chelation can be achieved by inhibition of the contact pathway by corn trypsin inhibitor (CTI)...
  36. doi Anticoagulant activity of captopril
    Arthur S Brecher
    Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, USA
    J Cardiovasc Pharmacol 51:99-105. 2008
    ..Lisinopril at a pharmacological 10(-2) M also prolonged APTT, although it lacks a thiol group. Polylysine (1k-4k) affected a prolongation of APTT at 6.7 x 10(-6) M, suggesting inhibition of clotting by a different mechanism...
  37. ncbi Clotting profiles in newborn maltese kids during the first week of life
    Giuseppe Piccione
    Dipartimento di Morfologia, Biochimica, Fisiologia e Produzione Animale, Facolta di Medicina Veterinaria, Universita di Messina, Messina, Italy 98168
    J Vet Diagn Invest 20:114-8. 2008
    ..the first week after birth, the prothrombin time (PT), the activated partial thromboplastin time (aPTT), the thrombin time (TT), and fibrinogen were assessed...
  38. ncbi [Study of anticoagulant activity of ethanol extracts from leech in vitro]
    Guang jun Feng
    Institute of Pharmaceutical Science, College of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, China
    Zhong Yao Cai 30:909-11. 2007
    ..To study the anticoagulant activity of different portions of leech ethanol extracts (LEEs)...
  39. ncbi Ivermectin and coagulation: an in vitro study
    J Hay
    School of Pharmacy, Leicester Polytechnic
    Ann Trop Med Parasitol 84:503-6. 1990
    ..No difference in these coagulation tests, relative to untreated controls, was observed after 12 hours' incubation with the drug...
  40. ncbi Inhibitory effect of JTV-803, a new cyclic guanidine derivative, on factor Xa in vitro and in vivo
    M Hayashi
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, 1-1 Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan
    Eur J Pharmacol 428:163-8. 2001
    ..JTV-803 produced more than 20% inhibition of human factor Xa for 8 h. Taken together, the results indicate JTV-803 is a long-acting oral anticoagulant which exerts its effect via specific inhibition of human factor Xa...
  41. ncbi A new recombinant thrombolytic and antithrombotic agent with higher fibrin affinity - a staphylokinase variant. An in-vivo study
    Janusz Szemraj
    Department of Medical Biochemistry, Medical University of Lodz, 92 215 Lódź Mazowiecka 6 8, Poland
    Thromb Haemost 97:1037-45. 2007
    ..Furthermore, our results also suggest that SAK-RGD-K2-Hir bears a risk of bleeding, but this may be true for higher doses...
  42. ncbi Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Thromb Haemost 98:1193-9. 2007
    ..Altogether, heparanase pro-coagulant activities that were also demonstrated in plasma samples from patients under LMWH treatment, point to a possible use of this molecule as antagonist for heparinoid treatment...
  43. doi Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes
    Meng Meng
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    J Control Release 128:113-9. 2008
    ....
  44. ncbi Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin
    E Koch
    Preclinical Research, Dr Willmar Schwabe GmbH and Co KG, Karlsruhe, Germany
    Phytomedicine 14:40-5. 2007
    ..No effect on thromboplastin time (TPT), partial TPT (PTPT) or thrombin time (TT) was observed after oral administration of EPs 7630 (10, 75, 500 mg/kg) for 2 weeks, while treatment with ..
  45. ncbi Amidolytic heparin activity and values for several hemostatic variables after repeated subcutaneous administration of high doses of a low molecular weight heparin in healthy dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine of Hanover, Germany
    Am J Vet Res 62:595-8. 2001
    ..collected before and 2 hours after the first, second, third, and sixth injections to measure heparin activity, thrombin time, activated partial thromboplastin time (APTT), antithrombin activity, Hct, and platelet count...
  46. doi Temporarily successful eradication therapy in acquired haemophilia with high inhibitor titer: a case report with a new protocol
    Peter Ilonczai
    University of Debrecen, Medical and Health Science Center, 2nd Department of Medicine, Division of Haemostasis, 4032, Nagyerdei krt 98 Debrecen, Hungary
    Thromb Haemost 100:149-50. 2008
  47. ncbi Thrombin inhibition with melagatran does not attenuate renal ischaemia-reperfusion injury in rats
    Nicoletta Nitescu
    Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Nephrol Dial Transplant 22:2149-55. 2007
    ..The aim of the present study was to examine the effects of selective thrombin inhibition with melagatran on kidney morphology and function in rats subjected to renal IR...
  48. ncbi Purification and characterization of patagonfibrase, a metalloproteinase showing alpha-fibrinogenolytic and hemorrhagic activities, from Philodryas patagoniensis snake venom
    M E Peichoto
    Facultad de Ciencias Exactas y Naturales y Agrimensura, Universidad Nacional del Nordeste, Corrientes, Argentina
    Biochim Biophys Acta 1770:810-9. 2007
    ..Thus, patagonfibrase may play a key role in the pathogenesis of disturbances that occur in P. patagoniensis envenomation, and may be used as a biological tool to explore many facets of hemostasis...
  49. ncbi Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
    M E Duarte
    , , PO Box 19046, CEP 81531-990 Curitiba, , Brazil
    Carbohydr Res 333:281-93. 2001
    ..In fucoidans from the second set, the 'core' is reduced to short galactan chains...
  50. ncbi Anticoagulant activities of a monoclonal antibody that binds to exosite II of thrombin
    F Lian
    Division of Hematology, Department of Internal Medicine, Washington University, St. Louis, Missouri 63110, USA
    Biochemistry 40:8508-13. 2001
    ..from a patient with multiple myeloma has been shown to bind to exosite II of thrombin, prolong both the thrombin time and the activated partial thromboplastin time (aPTT) when added to normal plasma, and alter the kinetics of ..
  51. ncbi Effects of Danshensu on maternal syndrome in phosphatidylserine/phosphatidylcholine microvesicle induced-mouse model: is it a candidate for preeclampsia remedy?
    Yang Shen
    Department of Obstetrics and Gynecology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China
    Chin Med J (Engl) 123:895-900. 2010
    ..This study aimed to evaluate the effects of Danshensu on maternal syndrome in phosphatidylserine/phosphatidylcholine (PS/PC) microvesicle induced-mouse model...
  52. ncbi Cutaneous and systemic effects of varying doses of brown recluse spider venom in a rabbit model
    David L McGlasson
    Clinical Research Squadron MSRL, Lackland AFB, TX 78236 5300, USA
    Clin Lab Sci 20:99-105. 2007
    ..Establishment of a dose-response relationship is an important first step in determining if the NZW rabbit is a suitable model to study both cutaneous and systemic effects of the venom...
  53. ncbi Effect of two low-dose gestodene containing monophasic oral contraceptives on hemostasis in Bulgarian women
    Ekaterina Uchikova
    Department of Obstetrics and Gynecology, Medical University, 4000 Plovdiv, Bulgaria
    Expert Opin Pharmacother 9:1839-44. 2008
    ..To compare the effects of two monophasic oral contraceptives upon coagulation, fibrinolysis and the system of natural inhibitors (anticoagulant pathways) in Bulgarian women...
  54. pmc Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time
    C N Berry
    Pre Clinical Research Department, , Bagneux, France
    Br J Pharmacol 113:1209-14. 1994
    ..antithrombotic effects of argatroban were accompanied by only moderate changes in the coagulation parameters (thrombin time and activated partial thromboplastin time, APTT), whereas, even at a subthreshold dose of heparin (12...
  55. doi [Impact of heparin on coagulation index during the therapy of molecular adsorbent recirculating system in patients with liver failure]
    Su e Yuan
    Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:830-5. 2011
    ..To investigate the impact of coagulative parameters on different anticoagulation systems in molecular adsorbent recirculating system (MARS) in subjects with liver failure, and to evaluate the safety of different anticoagulation methods ...
  56. ncbi Early graft function and carboxyhemoglobin level in liver transplanted patients
    Yasser Ali
    Anesthesia Department, King Faisal Specialist Hospital and Research Centre Anesthesia Department MBC22, Riyadh 11211, KSA
    Middle East J Anesthesiol 19:513-25. 2007
    ..We hypothesized that there may be a correlation between carboxyhemoglobin level and early graft function in patients undergoing liver transplant surgeries...
  57. ncbi [Perioperative changes of coagulation functions in the local advanced liver cancer patients receiving liver transplantation]
    Hao Yuan Wang
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 27:743-7. 2008
    ..This study was to explore perioperative changes of coagulation functions in the local advanced liver cancer patients who received liver transplantation...
  58. ncbi Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time
    Sebastian Harder
    Pharmazentrum Frankfurt, Institute for Clinical Pharmacology, University Hospital, Frankfurt am Main, Germany
    Thromb Haemost 91:1137-45. 2004
    ..The standard monitoring test for VKA, pro-thrombin time (PT), is prolonged by direct thrombin inhibitors...
  59. ncbi Defibrinogenating enzymes
    W R Bell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Drugs 54:18-30; discussion 30-1. 1997
    ..These venom fractions can be substituted for thrombin in performing the thrombin time and in removing fibrinogen from plasma for accurate determination of fibrinogen-fibrin degradation products.
  60. ncbi Effect of gamma irradiation with 30 Gy on the coagulation system in leukoreduced fresh-frozen plasma
    Volker Weisbach
    Department of Transfusion Medicine and Hemostaseology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Transfusion 47:1658-65. 2007
    ..The aim of this study was to investigate the effect of gamma irradiation with 30 Gy on the coagulation system in leukoreduced fresh-frozen plasma (FFP)...
  61. ncbi [Thrombocyte dysfunction in children with albinism]
    Z Pap
    Városi Egészségügyi Szolgálat, Debrecen
    Orv Hetil 138:467-71. 1997
    ..In 6 patients coagulation screening tests (prothrombin time, activated partial thromboplastin time, thrombin time) were normal, in 1 patient prolongation of activated partial thromboplastin time due to mild factor XI ..
  62. ncbi How useful is the monitoring of (low molecular weight) heparin therapy by anti-Xa assay? A laboratory perspective
    Emmanuel J Favaloro
    Department of Haematology and RCPA Quality Assurance Program QAP, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
    Lab Hematol 11:157-62. 2005
    ..0 U/mL. Tests to be performed were the activated partial thromboplastin time (APTT), the thrombin time (TT), fibrinogen, and anti-Xa...
  63. ncbi Filtration of methylene blue-photooxidized plasma: influence on coagulation and cellular contamination
    J Riggert
    Department of Transfusion Medicine, University of Gottingen, Gottingen, Germany
    Transfusion 41:82-6. 2001
    ..Subsequent filtration may increase the efficacy of virus inactivation and reduce adverse effects of WBC contamination and MB...
  64. ncbi Clotting alterations in primary systemic amyloidosis
    G Gamba
    Istituto di Medicina Interna e Oncologia Medica, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Haematologica 85:289-92. 2000
    ..This investigation was aimed at defining the prevalence of clotting abnormalities and their clinical manifestations in patients with AL...
  65. ncbi The effects of unfractionated heparin, low molecular weight heparin and danaparoid on the thromboelastogram (TEG): an in-vitro comparison of standard and heparinase-modified TEGs with conventional coagulation assays
    Jason A Coppell
    Haemophilia Centre and Haemostasis Unit, Royal Free Hospital, London, UK
    Blood Coagul Fibrinolysis 17:97-104. 2006
    ..DPD on standard TEG parameters were compared with the prothrombin time, activated partial thromboplastin time, thrombin time and anti-activated factor X (anti-FXa) activity, at concentrations of these anticoagulants ranging from 0...
  66. ncbi Correlation between the extent of platelet activation in platelet concentrates and in vitro and in vivo parameters
    M J Dijkstra-Tiekstra
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Vox Sang 87:257-63. 2004
    ..between platelet activation and in vivo parameters [the volume of thorax drain fluid as a measure of blood loss, platelet count, international normalized ratio (INR), and activated partial thrombin time (APTT)] in a clinical pilot study.
  67. doi One-stage prothrombin time, activated partial thromboplastin time, thrombin time, fibrin degradation product concentration, and antithrombin activity in healthy adult alpacas
    Amanda M House
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Vet Clin Pathol 40:195-7. 2011
    ..alpaca reference intervals for one-stage prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), concentration of fibrin degradation products (FDP), and antithrombin (AT) activities are scarce or ..
  68. ncbi Dextran sulfate included in factor Xa assay reagent overestimates heparin activity in patients after heparin reversal by protamine
    Christine Mouton
    Haemobiology Laboratory, Cardiologic Hospital, C H U de Bordeaux, Avenue Magellan, Pessac 33604, France
    Thromb Res 111:273-9. 2003
    A lack of correlation between activated partial thromboplastin time (aPTT), thrombin time (TT) and anti-factor Xa (AXa) activity was observed in patients after cardiac surgery with cardiopulmonary bypass (CBP)...
  69. doi Congenital prekallikrein deficiency
    Antonio Girolami
    Department of Medical and Surgical Sciences, Padua University, Via Ospedale, Padua, Italy
    Expert Rev Hematol 3:685-95. 2010
    ..based on the presence of a great prolongation of partial thromboplastin time and normal prothrombin time and thrombin time. The long partial thromboplastin time is fully corrected by the addition of normal plasma or normal serum and ..
  70. ncbi Disseminated intravascular coagulation in cattle with abomasal displacement
    K Irmak
    Department of Internal Medicine, Faculty of Veterinary Medicine, University of Selcuk, Campus, 42031, Konya, Turkey
    Vet Res Commun 29:61-8. 2005
    ..of platelets (PLT) and coagulation tests (activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), serum fibrin/fibrinogen degradation products (FDPs), fibrinogen) were measured before the surgical ..
  71. ncbi [Study on dynamic changes in coagulability and von Willebrand factor and its correlation with prognosis of cardiopulmonary resuscitation]
    Jing Xia Zhou
    Emergency Department of Chengde Central Hospital, Chengde 067000, Hebei, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:734-7. 2009
    ..To investigate dynamic changes in coagulability and von Willebrand factor (vWF), and explore their correlation with prognosis of cardiopulmonary resuscitation (CPR)...
  72. ncbi [Relationship between coagulation function and international prognostic index in lymphoma patients]
    Ya Jun Jiang
    Department of Hematology, Second Municipal People Hospital of Lianyungang, Lianyungang 222002, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1489-93. 2010
    ..The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) were detected by magnetic bead method in 75 lymphoma patients and 20 healthy persons...
  73. doi Impact of fibrinogen concentration in severely ill patients on mechanical properties of whole blood clots
    Carl Erik Dempfle
    First Department of Medicine, Germany bDepartment of Anaesthesiology and Operative Intensive Care, University Hospital of Mannheim, Mannheim, Germany
    Blood Coagul Fibrinolysis 19:765-70. 2008
    ..In contrast, clotting time assays such as prothrombin time, thrombin time, or activated partial thromboplastin time are influenced by the fibrinogen concentration only at levels below ..
  74. ncbi Bleeding tendency in Wolfram syndrome: a newly identified feature with phenotype genotype correlation
    M Al-Sheyyab
    Department of Pediatrics, School of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    Eur J Pediatr 160:243-6. 2001
    ..All individuals in the three study groups have normal platelet count, thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (aPTT), clot retraction, Factor VIII ..
  75. pmc The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    Joachim Stangier
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Br J Clin Pharmacol 64:292-303. 2007
    ..Two double-blind, randomized trials were undertaken to investigate the pharmacokinetics (PK), pharmacodynamics (PD) and tolerability of orally administered dabigatran etexilate in healthy male subjects...
  76. ncbi Activations of coagulation and fibrinolysis secondary to bowel inflammation in patients with ulcerative colitis
    Keiichiro Kume
    Department of Gastroenterology and Metabolism, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyusyu
    Intern Med 46:1323-9. 2007
    ..Thus, our aim was to evaluate the hyper states of coagulation and fibrinolysis in UC by comparing activations of coagulation and fibrinolysis in patients with active UC and in those with IC...
  77. doi Osteonecrosis in patients after severe acute respiratory syndrome (SARS): possible role of anticardiolipin antibodies
    Wei Sun
    Department of Orthopaedic Surgery, Center for Osteonecrosis and Joint Preserving and Reconstruction, China Japan Friendship Hospital, Beijing, People s Republic of China
    J Clin Rheumatol 16:61-3. 2010
    ....
  78. ncbi [The application of disseminated intravascular coagulation score in sepsis]
    Rong Qing Sun
    Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:478-80. 2009
    ..To study the relationship between the disseminated intravascular coagulation (DIC) score and assessment of illness and prognosis in sepsis...
  79. doi Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins
    Jiao Zheng
    School of Life Science and Technology, China Pharmaceutical University, Nanjing, China
    Clin Hemorheol Microcirc 42:29-36. 2009
    ..Fg) levels and prolonging the blood coagulation times including activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT)...
  80. ncbi Effect of natural honey on human platelets and blood coagulation proteins
    Asif Ahmed
    Department of Pharmacology, Baqai Medical University, Karachi, Pakistan
    Pak J Pharm Sci 24:389-97. 2011
    ..aggregation and blood coagulation employing, activated partial prothrombin time (aPTT), prothrombin time (PT), thrombin time (TT) and fibrinogen levels in blood...
  81. ncbi Purification and preliminary characterization of a plasma kallikrein inhibitor isolated from sea hares Aplysia dactylomela Rang, 1828
    Y Gonzalez
    Facultad de Biologia, Centro de Estudio de las Proteinas, Universidad de La Habana, Ciudad de La Habana
    Toxicon 43:219-23. 2004
    ..The inhibitor did not affect prothrombin time or thrombin time. AdKi is a more specific inhibitor than other serine proteinase inhibitors from marine invertebrates.
  82. ncbi Global fibrinolytic capacity is decreased in polycystic ovary syndrome, suggesting a prothrombotic state
    Bulent O Yildiz
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey, 06100
    J Clin Endocrinol Metab 87:3871-5. 2002
    ..total cholesterol; HDL-cholesterol (HDL-C); lipoprotein-a; prothrombin time; partial thromboplastin time; thrombin time; antithrombin III; factors II, V, VII, and X; fibrinogen; plasminogen; antiplasmin; and D-dimer...
  83. ncbi Causes of isolated prolonged activated partial thromboplastin time in an acute care general hospital
    W J Chng
    Department of Pathology and Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 380433
    Singapore Med J 46:450-6. 2005
    ..To determine the causes of isolated prolonged activated partial thromboplastin time (APTT) in an acute care general hospital setting so as to rationalise fresh frozen plasma usage...
  84. ncbi Coagulation disorders and inhibitors of coagulation in children from Mansoura, Egypt
    Nabil Abdelrazik
    Department of Pediatrics, Mansoura University Children Hospital, Mansoura, Egypt
    Hematology 12:309-14. 2007
    ..platelet count, bleeding time (BT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT)...
  85. ncbi Ser234Leu missense mutation in the A1 domain of factor V causing moderate factor V deficiency in a Chinese family
    Pei pei Jin
    Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Pathology 41:566-71. 2009
    ..To investigate the molecular defects in a Chinese pedigree with inherited factor V (FV) deficiency...
  86. ncbi Plasma volume expansion with Haemaccel does not impair haemostasis during reduction mammaplasty
    V Van Wyk
    Department of Haematology, University of the Orange Free State, Bloemfontein
    S Afr J Surg 36:22-5; discussion 25-6. 1998
    ..An in vivo study under well-controlled conditions was undertaken to determine the effect of Haemaccel, a colloidal plasma volume expander, on normal haemostasis...
  87. ncbi Evaluation of primary haemostasis in people with neurofibromatosis type 1
    E J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Western Sydney Area Health Service, Westmead, NSW, Australia
    Clin Lab Haematol 26:341-5. 2004
    ..routine coagulation parameters [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen], coagulation factors II, V, VII, VIII, IX, X, XI and XII, von Willebrand (VWF) factor ..
  88. doi The thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis
    Jieying Fu
    Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, China
    Thromb Res 122:683-90. 2008
    ..Miniplasmin was a des-kringle variant of plasminogen with potential pharmacological application. We investigated the thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis...
  89. ncbi Is the activated partial thromboplastin time suitable to screen for von Willebrand factor deficiencies?
    Giuseppe Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro 10, 37134 Verona, Italy
    Blood Coagul Fibrinolysis 18:361-4. 2007
    ..time, von Willebrand factor antigen, intrinsic pathway clotting factors activity, lupus anticoagulants and thrombin time. Thirty-seven patients were diagnosed with haemostasis disturbances other than von Willebrand factor ..
  90. doi Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals, patients under oral anticoagulation therapy and patients with liver dysfunction
    Robert Siegmund
    Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universitatsklinikum Jena, Jena, Germany
    Blood Coagul Fibrinolysis 19:288-93. 2008
    ..Consequently, prothrombin time, activated partial thromboplastin time, thrombin time, batroxobin time, coagulation factor activity (FII-FXIII), protein S (activity), protein C (chromogen) and ..
  91. ncbi Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples
    V Pengo
    Clinical Cardiology, Thrombosis Centre, University Hospital, Padova, Italy
    J Thromb Haemost 5:925-30. 2007
    ..To determine whether the diagnosis of lupus anticoagulant (LAC) in a large cohort of positive patients was confirmed at a reference laboratory...
  92. ncbi Predictive role of serum procollagen III peptide and Knodell's index in survival prognosis of patients with hepatitis B virus liver cirrhosis
    Zarko Babic
    Division of Gastroenterology and Hepatology, University Department of Medicine, Sv Duh General Hospital, Zagreb, Croatia
    Wien Klin Wochenschr 115:302-8. 2003
    ....
  93. ncbi Effect of chitosan molecular weight and deacetylation degree on hemostasis
    Jian Yang
    Tianjin Institute of Medical Equipment, Tianjin 300161, People s Republic of China
    J Biomed Mater Res B Appl Biomater 84:131-7. 2008
    ..The values of thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen concentration (FIB) ..
  94. pmc Molecular adsorbent recirculating system and hemostasis in patients at high risk of bleeding: an observational study
    Peter Faybik
    Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Austria
    Crit Care 10:R24. 2006
    ..The aim of the study was to evaluate the effects of liver support using a molecular adsorbent recirculating system (MARS) on the coagulation system in patients at high risk of bleeding...
  95. ncbi DIC secondary to acute pancreatitis
    M W Saif
    Division of Hematology Oncology and Department of Clinical Pharmacology Toxicology, University of Alabama at Birmingham UAB, 263 Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294, USA
    Clin Lab Haematol 27:278-82. 2005
    ..Coagulation work-up revealed thrombin time 24.3 s fibrinogen 110 mg/dl, D-dimers >1 and < 2, and fibrin degradation products >22...
  96. doi Intrauterine fetal death and delivery complications associated with coagulopathy: a retrospective analysis of 104 cases
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    J Womens Health (Larchmt) 18:469-74. 2009
    ..To assess the prevalence of delivery complications associated with coagulopathy in women with intrauterine fetal death (IUFD)...
  97. doi Comparison of the fibrinogen Clauss assay and the fibrinogen PT derived method in patients with dysfibrinogenemia
    W Miesbach
    Haemophilia Center, Medical Clinic III Institute of Transfusion Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Thromb Res 126:e428-33. 2010
    ..In addition, immunological and heat fibrinogen concentrations as well as global coagulation tests were measured...
  98. ncbi Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats
    Kung Chi Chan
    Department of Food and Nutrition, Providence University, Sha Lu, Taichung, Taiwan, ROC
    Food Chem Toxicol 45:502-7. 2007
    ..Garlic oil supplement at 5 or 50mg garlic oil/kg bodyweight significantly prolonged bleeding time and thrombin time, and enhanced anticoagulation factor activity, such as antithrombin III and protein C (P<0.05)...
  99. doi Effect of caffeic acid phenethyl ester on the hemostatic alterations associated with toxic-induced acute liver failure
    Aida A Korish
    Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    Blood Coagul Fibrinolysis 21:158-63. 2010
    ..glutamic pyruvic transaminase), total bilirubin, prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen level, anti-thrombin III levels, platelet count and antioxidative enzymes; catalase and superoxide ..
  100. ncbi Thrombotic reactant markers in non-ST segment elevation acute coronary syndromes treated with either enoxaparin (low molecular weight heparin) or unfractionated heparin
    E Gurfinkel
    Institute of Cardiology and Cardiovascular Surgery, Favaloro, Foundation, Buenos Aires, Argentina
    J Thromb Thrombolysis 8:227-32. 1999
    ....
  101. ncbi Heparin-like anticoagulant associated with multiple myeloma and neutralized with protamine sulfate
    Lamia Torjemane
    Centre National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia
    Blood Coagul Fibrinolysis 18:279-81. 2007
    ..Routine coagulation studies revealed a prolonged activated partial thromboplastin time and thrombin time (> 60 s) with a normal reptilase time...

Research Grants25

  1. Symphony Multiplex Peptide Synthesizer w/ VISION Workstn
    Kenneth Mann; Fiscal Year: 2004
    ..There is currently no preparative HPLC system on the campus of the University of Vermont and this system is badly needed for many investigators. ..
  2. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2007
    ..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
  3. HEMOSTASIS AND THROMBOSIS PROGRAM FOR ACADEMIC TRAINEES
    Kenneth Mann; Fiscal Year: 2007
    ..Trainees are therefore well prepared for future research endeavors in any field. (End of Abstract) ..
  4. Transfusion Medicine/Hemostasis Clinical Research Network
    Ronald Strauss; Fiscal Year: 2007
    ..Many millions more have problems with thrombocytopenia, neutropenia and anemia. This network has established a building block for future research to help treat and combat these problems. UNIVERSITY OF IOWA CRITIQUES ..
  5. Surface Dependent Reactions in Thrombosis and Thrombolysis
    Kenneth Mann; Fiscal Year: 2007
    ..abstract_text> ..
  6. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2003
    ..abstract_text> ..
  7. PE BIOSYSTEMS VOYAGER DE MALDI-TOF
    Kenneth Mann; Fiscal Year: 2001
    ..The fulfillment of the specific aims described in detail in the twelve research proposals would be facilitated by the addiction of a Voyager-DE MALDI-TOF ..