partial thromboplastin time

Summary

Summary: The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.

Top Publications

  1. ncbi Biological activities of sulfated polysaccharides from tropical seaweeds
    L S Costa
    UFRN, Laboratório de Biotecnologia de Polímeros Naturais Biopol, Centro de Biociencias, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Av Sen Salgado Filho, 3000, 59072970 Natal, Rio Grande do Norte, Brazil
    Biomed Pharmacother 64:21-8. 2010
  2. ncbi Heterofucans from Dictyota menstrualis have anticoagulant activity
    I R L Albuquerque
    , , Universidade Federal do Rio Grande do Norte, 59072-970 Natal, RN, Brazil
    Braz J Med Biol Res 37:167-71. 2004
  3. ncbi Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time
    Lorna M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Am J Hum Genet 86:626-31. 2010
  4. ncbi Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora
    T M A Silva
    , , Universidade Federal do Rio Grande do Norte, Natal, Brasil
    Braz J Med Biol Res 38:523-33. 2005
  5. ncbi Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities
    Rafael Barros Gomes Camara
    Laboratory of Biotechnology of Natural Polymers, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal RN, Brazil
    Mar Drugs 9:124-38. 2011
  6. ncbi Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time
    A Cuker
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Thromb Haemost 7:80-6. 2009
  7. ncbi Biphasic activated partial thromboplastin time waveform and adverse events in non-intensive care unit patients
    Eve Y Smith
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Clin Pathol 121:138-41. 2004
  8. ncbi A diagnostic challenge: mild hemophilia B with normal activated partial thromboplastin time
    Chang Hun Park
    Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 21:368-71. 2010
  9. ncbi How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults
    Arif H Kamal
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 82:864-73. 2007
  10. ncbi [Risk of hemorrhage after adenoidectomy and tonsillectomy. Value of the preoperative determination of partial thromboplastin time, prothrombin time and platelet count]
    K Scheckenbach
    Klinik fur Hals, Nasen, Ohren Krankheiten, Medizinische Einrichtungen der Heinrich Heine Universität Düsseldorf, Moorenstrasse 5, 40225 Dusseldorf, Deutschland
    HNO 56:312-20. 2008

Research Grants

  1. Dual Direct Inhibitors of Thrombin and Factor Xa
    Umesh Desai; Fiscal Year: 2009
  2. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2010
  3. EFFECTS OF TF/FVIIa INHIBITION IN CRP TRANSGENIC MICE
    Christopher Arnold; Fiscal Year: 2004
  4. MECHANISMS OF VASCULAR DYSFUNCTION IN HOMOCYSTEINEMIA
    STEVEN LENTZ; Fiscal Year: 2003
  5. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    STEVEN LENTZ; Fiscal Year: 2009
  6. MECHANISMS OF VASCULAR DYSFUNCTION IN HOMOCYSTEINEMIA
    STEVEN LENTZ; Fiscal Year: 2007
  7. Program in Hematology:& Cell Biology Blood Cells
    STEVEN LENTZ; Fiscal Year: 2007
  8. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    Steven R Lentz; Fiscal Year: 2010
  9. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
  10. Stabilized factor VIIIa as improved therapy for hemophilia A
    ANDREW GALE; Fiscal Year: 2007

Detail Information

Publications220 found, 100 shown here

  1. ncbi Biological activities of sulfated polysaccharides from tropical seaweeds
    L S Costa
    UFRN, Laboratório de Biotecnologia de Polímeros Naturais Biopol, Centro de Biociencias, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Av Sen Salgado Filho, 3000, 59072970 Natal, Rio Grande do Norte, Brazil
    Biomed Pharmacother 64:21-8. 2010
    ..In the activated partial thromboplastin time (APTT) test, which evaluates the intrinsic coagulation pathway, seven seaweeds presented anticoagulant ..
  2. ncbi Heterofucans from Dictyota menstrualis have anticoagulant activity
    I R L Albuquerque
    , , Universidade Federal do Rio Grande do Norte, 59072-970 Natal, RN, Brazil
    Braz J Med Biol Res 37:167-71. 2004
    ..The anticoagulant activity of these heterofucans was determined by activated partial thromboplastin time (APTT) using citrate normal human plasma. Only the fucans F1.0v and F1.5v showed anticoagulant activity...
  3. ncbi Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time
    Lorna M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Am J Hum Genet 86:626-31. 2010
    Activated partial thromboplastin time (aPTT) is associated with risk of thrombosis and coagulation disorders...
  4. ncbi Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora
    T M A Silva
    , , Universidade Federal do Rio Grande do Norte, Natal, Brasil
    Braz J Med Biol Res 38:523-33. 2005
    ..5-fold lesser than low molecular weight heparin) estimated by activated partial thromboplastin time was completely abolished upon desulfation by solvolysis in dimethyl sulfoxide, indicating that 3-O-..
  5. ncbi Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities
    Rafael Barros Gomes Camara
    Laboratory of Biotechnology of Natural Polymers, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal RN, Brazil
    Mar Drugs 9:124-38. 2011
    ..However, all polysaccharides prolonged activated partial thromboplastin time (aPTT). Four sulfated polysaccharides (CC-0.3/CC-0.5/CC-0.7/CC-1.0) doubled aPTT with only 0...
  6. ncbi Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time
    A Cuker
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Thromb Haemost 7:80-6. 2009
    ..the College of American Pathologists (CAP) recommends that the therapeutic range of the activated partial thromboplastin time (APTT) be defined in each laboratory through correlation with a direct measure of heparin activity such ..
  7. ncbi Biphasic activated partial thromboplastin time waveform and adverse events in non-intensive care unit patients
    Eve Y Smith
    Department of Pathology, Division of Laboratory Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Clin Pathol 121:138-41. 2004
    The purpose of the present study was to determine whether the presence of a biphasic activated partial thromboplastin time (aPTT) waveform (BPW) is associated with adverse clinical outcomes among patients not in an intensive care unit (..
  8. ncbi A diagnostic challenge: mild hemophilia B with normal activated partial thromboplastin time
    Chang Hun Park
    Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Seoul, Korea
    Blood Coagul Fibrinolysis 21:368-71. 2010
    ..The diagnosis of hemophilia B is typically suspected by significantly prolonged activated partial thromboplastin time (aPTT) on screening tests, but aPTT may be normal or minimally prolonged in mild hemophilia B...
  9. ncbi How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults
    Arif H Kamal
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 82:864-73. 2007
    The prothrombin time (PT) and activated partial thromboplastin time (APTT) are among the most commonly ordered coagulation tests. In 2005, more than 140,000 PT and more than 95,000 APTT tests were performed at Mayo Clinic...
  10. ncbi [Risk of hemorrhage after adenoidectomy and tonsillectomy. Value of the preoperative determination of partial thromboplastin time, prothrombin time and platelet count]
    K Scheckenbach
    Klinik fur Hals, Nasen, Ohren Krankheiten, Medizinische Einrichtungen der Heinrich Heine Universität Düsseldorf, Moorenstrasse 5, 40225 Dusseldorf, Deutschland
    HNO 56:312-20. 2008
    ..Therefore, routine preoperative coagulation screening, including activated partial thromboplastin time (aPTT), prothrombin time (PT) and platelet count (PLC), are regularly performed, also for medicolegal ..
  11. ncbi The activated partial thromboplastin time in early diagnosis of myocardial infarction
    A M Madi
    Yale Prevention Research Center and The Department of Preventive Medicine, Griffin Hospital, Yale University School of Medicine, Derby, Connecticut 06418, USA
    Blood Coagul Fibrinolysis 12:495-9. 2001
    ..few studies have examined the diagnostic value of routine coagulability markers, such as the activated partial thromboplastin time (aPTT), in patients with chest pain...
  12. ncbi Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis
    M Ieko
    Departments of Internal Medicine, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido, Japan
    J Thromb Haemost 2:612-8. 2004
    ....
  13. ncbi Abnormally short activated partial thromboplastin times are related to elevated plasma levels of TAT, F1+2, D-dimer and FVIII:C
    Edwin ten Boekel
    Laboratory for Clinical Chemistry, Hematology and Immunology, Medical Center of Alkmaar, Alkmaar, The Netherlands
    Pathophysiol Haemost Thromb 32:137-42. 2002
    ..In conclusion, short APTTs are indicative of marked coagulation activity and elevated FVIII:C levels. Elevated FVIII:C levels may play a pathogenic role in the increased risk of thrombosis associated with abnormally short APTTs...
  14. ncbi Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time
    G Hron
    Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
    J Thromb Haemost 4:752-6. 2006
    ..OBJECTIVE: To assess if measurement of activated partial thromboplastin time (APTT) allows stratification of patients with VTE into high- and low-risk categories with regard to ..
  15. ncbi Global anticoagulant effects of a synthetic anti-factor Xa inhibitor (DX-9065a): implications for interventional use
    Mahmut Tobu
    Department of Pathology and Pharmacology, Loyola University, Maywood, Illinois, USA
    Clin Appl Thromb Hemost 9:1-17. 2003
    ..time assay, thrombelastography, and global clotting tests, such as prothrombin time (PT), activated partial thromboplastin time (aPTT), diluted aPTT, Heptest, Heptest-HI, dilute Russell's viper venom time (dRVVT), thrombin time, ..
  16. ncbi Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin
    Sonia S Anand
    McMaster Clinic Population Health Section, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada
    Circulation 107:2884-8. 2003
    ..The need for a therapeutic range with the activated partial thromboplastin time (APTT) has not been validated in patients with arterial thrombosis who receive heparin...
  17. ncbi A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Blood 104:3631-4. 2004
    ..These factors are cumulatively explored by the activated partial thromboplastin time (APTT)...
  18. ncbi First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial
    J H Alexander
    Duke University Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thromb Haemost 3:439-47. 2005
    ..Anticoagulants with predictable kinetics and anticoagulant effects, better efficacy, and greater safety are needed...
  19. ncbi Prothrombin time and partial thromboplastin time assay considerations
    Valerie L Ng
    Department of Laboratory Medicine, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    Clin Lab Med 29:253-63. 2009
    ..Thus, this article reviews laboratory issues and known variables influencing prothrombin time and partial thromboplastin time results and international normalized ratio determinations.
  20. ncbi Analysis of the activated partial thromboplastin time test using mathematical modeling
    A E Kogan
    Biological Faculty, Department of Biochemistry, Room 129, Moscow State University, 119899, Moscow, Russia
    Thromb Res 101:299-310. 2001
    Activated partial thromboplastin time (APTT) is a laboratory test for the diagnosis of blood coagulation disorders...
  21. ncbi Postpartum acquired hemophilia (factor VIII inhibitors): a case report and review of the literature
    S A Shobeiri
    Louisiana State University Health Sciences Center, Department of Obstetrics and Gynecology, New Orleans 70112, USA
    Obstet Gynecol Surv 55:729-37. 2000
    ..The literature concerning acquired hemophilia is reviewed, and new therapeutic medical advances are emphasized...
  22. ncbi Epidemiological association between fasting plasma glucose and shortened APTT
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, 37134 Verona, Italy
    Clin Biochem 42:118-20. 2009
    To investigate the relationship between fasting plasma glucose (FPG) and shortened activated partial thromboplastin time (APTT), an independent risk factor for thrombosis.
  23. ncbi Shortened activated partial thromboplastin time: causes and management
    Giuseppe Lippi
    Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Blood Coagul Fibrinolysis 21:459-63. 2010
    ..hemostasis laboratory, and as an evaluation of the coagulation cascade, the results of the activated partial thromboplastin time (APTT) have primarily been considered as an index of loss-of-function and rarely as an index of gain-of-..
  24. ncbi A laboratory evaluation into the short activated partial thromboplastin time
    Ashraf Mina
    Department of Endocrinology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 1245, Australia
    Blood Coagul Fibrinolysis 21:152-7. 2010
    ....
  25. ncbi Effect of freezing method and storage at -20 degrees C and -70 degrees C on prothrombin time, aPTT and plasma fibrinogen levels
    Sonja Alesci
    University Hospital of Frankfurt, Hemophilia Center, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Thromb Res 124:121-6. 2009
    ..Prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen using a kinetic fibrinogen assay, PT-derived fibrinogen, and an immunoassay were ..
  26. ncbi Recombinant activated factor VII for adjunctive hemorrhage control in trauma
    U Martinowitz
    National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    J Trauma 51:431-8; discussion 438-9. 2001
    ..Therefore, use of the drug in trauma patients suffering uncontrolled hemorrhage appears to be rational...
  27. ncbi Stability of prothrombin time and activated partial thromboplastin time tests under different storage conditions
    L V Rao
    UTMB TDCJ Correctional Managed Care, Huntsville, TX, USA
    Clin Chim Acta 300:13-21. 2000
    Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are common laboratory tests that are useful in the diagnosis of coagulation disorders and monitoring anticoagulant therapy...
  28. ncbi Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force
    U Martinowitz
    National Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Thromb Haemost 3:640-8. 2005
    ....
  29. ncbi Coagulation profiles in dogs with congenital portosystemic shunts before and after surgical attenuation
    Anne Kummeling
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    J Vet Intern Med 20:1319-26. 2006
    ..Serious postoperative hemorrhage has been reported in dogs after closure of congenital portosystemic shunts (CPS)...
  30. ncbi Measurement of prothrombin time (PT) and activated partial thromboplastin time (APTT) on canine citrated plasma samples following different storage conditions
    F Rizzo
    Small Animal Hospital, School of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, UK
    Res Vet Sci 85:166-70. 2008
    ....
  31. ncbi Hemostatic profiles in 39 dogs with congenital portosystemic shunts
    J D Niles
    Small Animal Teaching Hospital, The University of Liverpool, England
    Vet Surg 30:97-104. 2001
    OBJECTIVES: To determine if there were significant changes in prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen levels in dogs with naturally occurring congenital portosystemic shunts (CPSS) and to determine if ..
  32. ncbi Plasma fibrinogen level, bleeding, and transfusion after on-pump coronary artery bypass grafting surgery: a prospective observational study
    Martin Karlsson
    Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
    Transfusion 48:2152-8. 2008
    ..We investigated the relationship between preoperative fibrinogen plasma concentration and postoperative bleeding and transfusion after coronary artery bypass grafting (CABG)...
  33. ncbi Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein
    Michael W Dennis
    Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, United Kingdom
    Thromb Haemost 91:522-30. 2004
    ..Using a modified activated partial thromboplastin time assay, the mean normal clot time decreased significantly when VLDL from patients with biphasic ..
  34. ncbi Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time
    J C Souto
    Unitat d Hemostasia i Trombosi, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 20:2024-8. 2000
    ..00075). In addition, factor VIII coagulant activity and activated partial thromboplastin time showed suggestive linkage with the ABO locus (P=0.10 and P=0.13)...
  35. ncbi The biphasic waveform in plasma: identifying the sepsis--coagulation crossroad? A rebuttal
    C H Toh
    J Thromb Haemost 3:604-5; author reply 605-6. 2005
  36. ncbi Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time
    Sebastian Harder
    Pharmazentrum Frankfurt, Institute for Clinical Pharmacology, University Hospital, Frankfurt am Main, Germany
    Thromb Haemost 91:1137-45. 2004
    ..A similar interference of the VKA on the activated partial thromboplastin time (aPTT), a monitoring assay for direct thrombin inhibitors, can occur...
  37. ncbi Utility of activated partial thromboplastin time waveform analysis for identification of sepsis and overt disseminated intravascular coagulation in patients admitted to a surgical intensive care unit
    Carl-Erik H Dempfle
    Department of Medicine, University Hospital of Mannheim, Germany
    Crit Care Med 32:520-4. 2004
    ..An abnormality of the optical transmission waveform obtained during measurement of the activated partial thromboplastin time (aPTT) has been described in association with overt disseminated intravascular coagulation...
  38. ncbi Effect of cardiopulmonary bypass on activated partial thromboplastin time waveform analysis, serum procalcitonin and C-reactive protein concentrations
    Bertrand Delannoy
    Department of Anesthesiology and Intensive Care, Hospices Civils de Lyon, Louis Pradel Hospital, 69500 Bron, France
    Crit Care 13:R180. 2009
    ..Biphasic waveform (BPW) analysis is a new biological test derived from activated partial thromboplastin time that has recently been proposed for sepsis diagnosis...
  39. ncbi Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time
    Myung S Park
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 67:266-75; discussion 275-6. 2009
    ..We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients...
  40. ncbi Acquired anti-FVIII inhibitors in children
    R J Moraca
    The Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center, PA, USA
    Haemophilia 8:28-32. 2002
    ..The median baseline FVIII was 0.05 U mL(-1), and the median baseline activated partial thromboplastin time (APTT) was 79.8 s...
  41. ncbi Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawal
    Cristina Legnani
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Br J Haematol 134:227-32. 2006
    This study prospectively evaluated the relationship between activated partial thromboplastin time (aPTT) and risk of venous thromboembolism (VTE) recurrence after oral anticoagulant (OA) withdrawal in patients with a previous unprovoked ..
  42. ncbi Combined prednisolone and intravenous immunoglobulin treatment for acquired factor VIII inhibitors: a 2-year review
    A C Dykes
    Haemophilia Centre, Glasgow Royal Infirmary, Glasgow, UK
    Haemophilia 7:160-3. 2001
    ..All patients were bleeding at the time of diagnosis with prolonged activated partial thromboplastin time. There were four complete responses, one partial response, one nonresponse and one with an inadequate ..
  43. ncbi Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients
    Ahmed N Zakariah
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 36:1507-12. 2008
    ..of combining measurement of blood procalcitonin (PCT) concentrations with the presence of a biphasic transmittance waveform (BPW) from the activated partial thromboplastin time (aPTT) to identify sepsis in critically ill patients.
  44. ncbi Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Jack Hirsh
    Henderson Research Centre, 711 Concession St, Hamilton, ON L8V 1C3, Canada
    Chest 126:188S-203S. 2004
    ..Variability in activated partial thromboplastin time (aPTT) reagents necessitates site-specific validation of the aPTT therapeutic range in order to ..
  45. ncbi Effect of argatroban on the activated partial thromboplastin time: a comparison of 21 commercial reagents
    John L Francis
    Florida Hospital Center for Thrombosis and Hemostasis, 2501 North Orange Avenue, Orlando, FL 32804, USA
    Blood Coagul Fibrinolysis 16:251-7. 2005
    ..We conclude that most aPTT reagents are similarly sensitive to argatroban, and reagent choice is unlikely to significantly affect argatroban monitoring in patients with heparin-induced thrombocytopenia...
  46. ncbi Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo
    Hans Ulrich Pauer
    Department of Gynecology and Obstetrics, Medical School, University of Goettingen, Germany
    Thromb Haemost 92:503-8. 2004
    ..FXII knockout (FXII(-)/(-)) mice showed no FXII plasma activity and had a markedly prolonged activated partial thromboplastin time (aPTT)...
  47. ncbi Inhibition of thrombin generation in plasma by inhibitors of factor Xa
    D Prasa
    Zentrum für Vaskuläre Biologie und Medizin, Klinikum der Friedrich Schiller Universitat Jena, Germany
    Thromb Haemost 78:1215-20. 1997
    ..In contrast, the highly potent FXa inhibitor r-TAP causes a stronger reduction of the thrombin activity in plasma than the most potent thrombin inhibitor hirudin...
  48. ncbi Activated partial thromboplastin time waveform analysis: a new tool to detect infection?
    Nicolas Chopin
    Service de Réanimation Chirurgicale and Laboratoire d Hémostase, Hospices Civils de Lyon, Hopital Edouard Herriot, Lyon, France
    Crit Care Med 34:1654-60. 2006
    An abnormality of the optical transmission waveform obtained during measurement of the activated partial thromboplastin time (aPTT) has been described to identify a high-risk intensive care unit population consisting of patients with ..
  49. ncbi Disagreement between bedside and laboratory activated partial thromboplastin time and international normalized ratio for various novel anticoagulants
    M J Kemme
    Centre for Human Drug Research, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 12:583-91. 2001
    ..studies on warfarin, heparin and various anticoagulants with novel mechanisms of action, the activated partial thromboplastin time (aPTT) and the (apparent) international normalized ratio (INR) from a bedside monitor (Coagucheck Plus(..
  50. ncbi Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca(++)-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation
    Cheng Hock Toh
    Departments of Biochemistry and Pathology, Queen's University, Kingston, ON, Canada
    Blood 100:2522-9. 2002
    ..The complex has been designated lipoprotein complexed C-reactive protein...
  51. ncbi Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects
    Ulf G Eriksson
    AstraZeneca R and D, 431 83 Mölndal, Sweden
    Eur J Clin Pharmacol 59:35-43. 2003
    ..The primary objectives were to determine the dose linearity and reproducibility of melagatran exposure and the influence of food intake...
  52. ncbi Transient acquired hemophilia associated with Mycoplasma pneumoniae pneumonia
    Min Sun Kim
    Department of Pediatrics and the Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, Korea
    J Korean Med Sci 23:138-41. 2008
    ..Hematologic studies showed a prolonged activated partial thromboplastin time (aPTT), partially corrected mixing test for aPTT, reduced levels of FVIII, and the presence of ..
  53. ncbi In vitro factor XI activation mechanism according to an optimized model of activated partial thromboplastin time test
    A Kramoroff
    , France
    Blood Coagul Fibrinolysis 12:289-99. 2001
    ..In this context, we have simulated theoretical activated partial thromboplastin time (aPTT) by means of a program based on a body of 22 essential elementary reactions implemented with rate ..
  54. ncbi Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor
    Atsushi Shinagawa
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Thromb Haemost 93:889-96. 2005
    ..Both the bleeding time (>25 min) and activated partial thromboplastin time (APTT) were prolonged...
  55. ncbi Experimental study on anticoagulant and antiplatelet aggregation activity of a chemically sulfated marine polysaccharide YCP
    Fang Han
    School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China
    Int J Biol Macromol 36:201-7. 2005
    ..activity and antiplatelet aggregation activity of these sulfated derivates were evaluated by activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and platelet aggregation assay...
  56. ncbi Effect of specimen collection on routine coagulation assays and D-dimer measurement
    Giuseppe Lippi
    Istituto di Chimica Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, , Verona, Italy
    Clin Chem 50:2150-2. 2004
  57. ncbi Results of a survey of hospital coagulation laboratories in the United States, 2001
    Shahram Shahangian
    Division of Laboratory Services, Coordinating Center for Health Information and Service, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Arch Pathol Lab Med 129:47-60. 2005
    ..Coagulation and bleeding problems are associated with substantial morbidity and mortality, and inappropriate testing practices may lead to bleeding or thrombotic complications...
  58. ncbi Coagulation assays
    Shannon M Bates
    Department of Medicine, McMaster University, Henderson Research Centre, Hamilton, Ontario, Canada
    Circulation 112:e53-60. 2005
  59. ncbi Anticoagulant effect of sodium dehydroacetate (DHA-S) in rats
    Yuka Sakaguchi
    Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc, 10 1, Tebiro 6 chome, Kamakura, Kanagawa 248 8555, Japan
    J Appl Toxicol 28:524-9. 2008
    ..Increased VK-dependent blood coagulation parameters, a prolonged prothrombin time (PT) and an activated partial thromboplastin time (APTT) were observed in rats when DHA-S alone was administered, while only a slight change was observed ..
  60. ncbi The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity
    You Seon Sa
    Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea
    Arch Pharm Res 28:667-74. 2005
    ..It delayed thrombin time (TT), activated partial thromboplastin time (APTT), and prothrombin time (PT) using human plasma...
  61. ncbi Pharmacokinetics and pharmacodynamics of warfarin when coadministered with pentosan polysulfate sodium
    Nishit B Modi
    ALZA Corp, Department of Clinical Pharmacology, 1900 Charleston Road, PO Box 7210, Mountain View, CA 94039-7210, USA
    J Clin Pharmacol 45:919-26. 2005
    ..Prothrombin time, partial thromboplastin time, and the international normalized ratio for warfarin + placebo and warfarin + pentosan polysulfate ..
  62. ncbi Utility of routine coagulation studies in emergency department patients with suspected acute coronary syndromes
    Dagan Schwartz
    Department of Emergency Medicine, Mt Sinai Medical Center, Cleveland, OH, USA
    Isr Med Assoc J 7:502-6. 2005
    ..Many emergency departments use coagulation studies in the evaluation of patients with suspected acute coronary syndromes...
  63. ncbi Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing
    Jonathan R Genzen
    Department of Pathology, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Clin Pathol 124:586-93. 2005
    ..curves were generated to calculate the concentration of anticoagulant that prolongs the activated partial thromboplastin time (aPTT) to 75 seconds (2.5 times the baseline average)...
  64. ncbi Preparation and anticoagulation activity of sodium cellulose sulfate
    Zhao Mei Wang
    Research Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China
    Int J Biol Macromol 41:376-82. 2007
    ..Results indicated that Na-MCS exhibited higher anticoagulation activity based on activated partial thromboplastin time (APTT) assay and prolonged the thrombin time (TT) to a lesser extent than heparin...
  65. ncbi Mitigation of coagulation by removing clotting factors part 1: in vitro feasibility study
    Jared T Parker
    Chemical Engineering Department, Brigham Young University, Provo, Utah 84602, USA
    ASAIO J 53:415-20. 2007
    ..II (prothrombin), VIII, and X, and proteins C and S, and for prothrombin time (PT), activated partial thromboplastin time (APTT), and total protein concentration...
  66. ncbi Improved coagulation and blood conservation in the golden hours after cardiopulmonary bypass
    Scott R Beckmann
    Salem Hospital, Salem, Oregon, USA
    J Extra Corpor Technol 39:103-8. 2007
    ..Hematocrit, platelet count, fibrinogen concentration ([Fib]), prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR) were compared between two prospective convenience ..
  67. ncbi [Study of a glycoprotein from Gastrodia elata: its effects of anticoagulation and antithrombosis]
    Cheng shi Ding
    Institute of Biochencistry and Nicrobiology, Anhui University, Hefei 230039, China
    Zhongguo Zhong Yao Za Zhi 32:1060-4. 2007
    ..To investigate the effects of polysaccharide 2-1 from Gastrodia elata (PGE2-1) on blood coagulation and thrombosis...
  68. ncbi Hemostasis and global fibrinolytic capacity in chronic liver disease
    Sirin Aytac
    Department of Gastroenterology, Guven Hospital, Ankara, Turkey
    Blood Coagul Fibrinolysis 18:623-6. 2007
    ..There was a significant positive relationship between the GFC and the prothrombin time and activated partial thromboplastin time values (P < 0.05)...
  69. ncbi Fibrinogen gamma' chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway
    Rehana S Lovely
    Department of Pathology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Br J Haematol 139:494-503. 2007
    ..The gamma' peptide inhibited the activated partial thromboplastin time in plasma and showed greater inhibition of activated partial thromboplastin time assays than ..
  70. ncbi Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Thromb Haemost 98:1193-9. 2007
    ..Altogether, heparanase pro-coagulant activities that were also demonstrated in plasma samples from patients under LMWH treatment, point to a possible use of this molecule as antagonist for heparinoid treatment...
  71. ncbi [Study of anticoagulant activity of ethanol extracts from leech in vitro]
    Guang jun Feng
    Institute of Pharmaceutical Science, College of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, China
    Zhong Yao Cai 30:909-11. 2007
    ..To study the anticoagulant activity of different portions of leech ethanol extracts (LEEs)...
  72. ncbi Thrombelastography in a patient with heparin-induced thrombocytopenia treated with argatroban
    Emily A Zayac
    Anesth Analg 106:351-2. 2008
  73. ncbi Anticoagulant activity of captopril
    Arthur S Brecher
    Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, USA
    J Cardiovasc Pharmacol 51:99-105. 2008
    ..exerted an anticoagulant effect upon clotting time as followed by prothrombin time (PT) and activated partial thromboplastin time (APTT), with prolongation of clotting observed at 4...
  74. ncbi Routine coagulation tests in newborn and young infants
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Ospedale Policlinico G B Rossi, Universita degli Studi di Verona, Piazzale Scuro, 10, 37134 Verona, Italy
    J Thromb Thrombolysis 24:153-5. 2007
    ..The diagnostic approach to haemostatic defects in the newborn is challenging and requires appropriate interpretation of coagulation tests according to reference values dependent on the postnatal age...
  75. ncbi Clinically applicable laboratory end-points for treating snakebite coagulopathy
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Pathology 38:568-72. 2006
    ..To determine which coagulation tests best reflect the return of clotting function after snakebite venom induced consumptive coagulopathy (VICC)...
  76. ncbi Effects of antithrombin and heparin cofactor II levels on anticoagulation with Intimatan
    Kenichi A Tanaka
    Department of Anesthesiology, The Emory Healthcare, Atlanta, Georgia, USA
    Thromb Haemost 94:808-13. 2005
    ..With the absence of both cofactors, neither agent alone or in combination had any effect on thrombin generation. We conclude that Intimatan may be an effective adjunct to heparin therapy under low AT conditions...
  77. ncbi Overuse of prothrombin and partial thromboplastin coagulation tests in medical inpatients
    Florian H Pilsczek
    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 610, Bronx, NY 10461, USA
    Heart Lung 34:402-5. 2005
    ..of anticoagulant therapy, prothrombin time (PT) is used to measure the effect of warfarin, whereas the partial thromboplastin time (PTT) measures the therapeutic effect of unfractionated heparin...
  78. ncbi Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation
    Theodore E Warkentin
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Thromb Haemost 94:958-64. 2005
    ..On a mole-for-mole basis, lepirudin was most able to prolong the PT, activated partial thromboplastin time (APTT), and thrombin clotting time (TCT), whereas argatroban had the least effect...
  79. ncbi Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia
    Judith M Leitner
    Department of Clinical Pharmacology, Division of Immunohaematology, Medical University of Vienna, Austria
    Clin Pharmacol Ther 79:23-34. 2006
    ..Effects on leukocytes and inhibition of interleukin-6 release seem to represent specific pharmacodynamic properties of recombinant human antithrombin...
  80. ncbi Design, synthesis and molecular modelling of 1-amidinopiperidine thrombin inhibitors
    I Smolnikar
    Faculty of Pharmacy, University of Ljubljana, University Medical Centre, Slovenia
    Pharmazie 62:243-54. 2007
    ..The binding conformation of inhibitors in the active site of thrombin was revealed by molecular modelling studies...
  81. ncbi Anticoagulant property of a semi-synthesized sodium beta-1,4-glucan sulfate
    Zhao Mei Wang
    Institute of Light Industry and Chemical Engineering, South China University of Technology, Guangzhou
    Yao Xue Xue Bao 41:323-7. 2006
    ..To investigate the anticoagulant efficacy and mechanism of a semi-synthesized sodium beta-1,4-glucan sulfate (Na-MCS)...
  82. ncbi Effect on routine and special coagulation testing values of citrate anticoagulant adjustment in patients with high hematocrit values
    Richard A Marlar
    Pathology and Laboratory Medicine Service, Oklahoma, City Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
    Am J Clin Pathol 126:400-5. 2006
    ..55-0.72]). Prothrombin time (PT) and activated partial thromboplastin time (aPTT) results from nonadjusted and adjusted samples were statistically different and exponentially ..
  83. ncbi Predilution versus postdilution during continuous venovenous hemofiltration: a comparison of circuit thrombogenesis
    Anne Cornelie J M de Pont
    Departments of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    ASAIO J 52:416-22. 2006
    ..In summary, predilution and postdilution did not differ with respect to extracorporeal circuit thrombogenesis. During postdilution, baseline platelet count and maximal prefilter pressure were inversely related with circuit survival time...
  84. ncbi Effects of a protease inhibitor, ulinastatin, on coagulation and fibrinolysis in abdominal surgery
    Tomoki Nishiyama
    Department of Anesthesiology, The University of Tokyo, Tokyo, Japan
    J Anesth 20:179-82. 2006
    ..White blood cell count; platelet count; prothrombin time; activated partial thromboplastin time; and plasma concentrations of PMNE, antithrombin (AT), fibrin/fibrinogen degradation product (FDP), ..
  85. ncbi Molecular characterization and anticoagulant activity of a novel annexin derived from the Taenia solium
    KaiHui Wang
    Department of Medical Genetics, The Second Military Medical University, Xiang Yin Road 800, Shanghai 200433, PR China
    Acta Trop 99:165-72. 2006
    ..Nevertheless, the mutant protein deleting the consensus coagulation-related KGD motif of Tso ANXB2 showed significant decreasing platelet binding and anticoagulation activity...
  86. ncbi The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution
    Thorsten Haas
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1360-5, table of contents. 2008
    ....
  87. ncbi The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin
    Seon-Joo Yoon
    , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Thromb Res 112:151-8. 2003
    ..The polysaccharides from these mushrooms may constitute a new source of compounds with action on coagulation, platelet aggregation and, perhaps, on thrombosis...
  88. ncbi A new blood coagulation inhibitor from the snake Bothrops jararaca plasma: isolation and characterization
    Anita M Tanaka-Azevedo
    Laboratorio de Fisiopatologia, Instituto Butantan, Sao Paulo, Brazil
    Biochem Biophys Res Commun 308:706-12. 2003
    ..Our findings indicate that BjI is an exosite binding thrombin inhibitor, specific upon coagulant activity thrombin inhibitor, without any anti-platelet aggregation activity...
  89. ncbi Significant increase of activated partial thromboplastin time by heparinization of the radial artery catheter flush solution with a closed arterial catheter system
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, Ghent, Belgium
    Crit Care Med 30:1030-4. 2002
    ..Evaluate whether the use of a heparinized flush for an arterial catheter with a closed-loop blood sampling system leads to erroneous coagulation studies...
  90. ncbi Decreased concentrations of heparinoids are required to inhibit thrombin generation in plasma from newborns and children compared to plasma from adults due to reduced thrombin potential
    Anthony K C Chan
    Hamilton Civic Hospitals Research Centre, Ontario, Canada
    Thromb Haemost 87:606-13. 2002
    ..Cord plasma was the most sensitive to inhibition, with ATH being more effective than UFH or LMWH...
  91. ncbi Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleeding
    Saskia E M Schols
    Department of Biochemistry CARIM, Maastricht University, Maastricht, The Netherlands
    Thromb Haemost 99:64-70. 2008
    ..For all patients, the transfusion led to higher plasma coagulation factor levels, a shortened activated partial thromboplastin time, and a significant increase in thrombin generation (peak height and endogenous thrombin potential)...
  92. ncbi Influence of functional groups on the in vitro anticoagulant activity of chitosan sulfate
    Ronghua Huang
    Department of Environment Science, Wuhan University, Hubei, 430072, Wuhan, China
    Carbohydr Res 338:483-9. 2003
    ..groups on the anticoagulant activity of the polysaccharides were studied with respect to activated partial thromboplastin time (APTT) thrombin time (TT), and prothrombin time (PT)...
  93. ncbi Investigations on blood coagulation in the green iguana (Iguana iguana)
    S Kubalek
    Clinic for Small Animals, School of Veterinary Medicine, Hanover, Germany
    J Vet Med A Physiol Pathol Clin Med 49:210-6. 2002
    The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time, kaolin clotting time (KCT), dilute Russell's viper venom time (DRVVT) and reptilase time, as well as five different plasma fibrinogen assays [..
  94. ncbi Anticoagulant from Taraxacum platycarpum
    Soo-In Yun
    Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Korea
    Biosci Biotechnol Biochem 66:1859-64. 2002
    ..255, and 873 nM, respectively, the protein doubled the thrombin time, prothrombin time, and activated partial thromboplastin time. It inhibited thrombin and kallikrein, but did not hydrolyze fibrinogen...
  95. ncbi Modifications of coagulation and fibrinolytic parameters in laparoscopic cholecystectomy
    R Vecchio
    Department of Surgery, University of Catania, Vittorio Emanuele Hospital, via Plebiscite 628, 95100 Catania, Italy
    Surg Endosc 17:428-33. 2003
    ..The incidence of deep vein thrombosis and pulmonary embolism following laparoscopic surgery is unknown and studies on alterations of hemostasis after laparoscopy are inconclusive...
  96. ncbi Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation
    Derek R Kieta
    Department of Anesthesiology, The University of Alabama at Birmingham, 619 South 19th Street, Birmingham, AL 35249-6810, USA
    Anesth Analg 96:956-8, table of contents. 2003
    ..IMPLICATIONS: This case describes the impact of argatroban and off-pump coronary revascularization on hemostasis as assessed by conventional hemostatic measures and Thrombelastography in a patient with heparin-induced thrombocytopenia...
  97. ncbi [Case report. Phenprocoumon (Marcumar, Falithrom) as an unusual reason for coumarin poisoning in a dog]
    G Lutze
    ,
    Dtsch Tierarztl Wochenschr 110:31-3. 2003
    ..HPLC did not reveal the presence of warfarin but of phenoprocoumon, a drug used for thromboembolic prophylaxis in humans. This observation has not been described for dogs to date...
  98. ncbi Differential effects of DX-9065a, argatroban, and synthetic pentasaccharide on tissue thromboplastin inhibition test and dilute Russell's viper venom test
    Rolandas Gerbutavicius
    Kaunas Medical University, Department of Hematology and Department of Drug Technology, Kaunas, Lithuania
    Clin Appl Thromb Hemost 9:317-23. 2003
    ..This effect should be considered during patient management. These results indicate that these assays could be used for the effective quantitation of the direct factor Xa or factor IIa inhibitors when suitable controls are used...
  99. ncbi Measurement of blood and plasma coagulation time using free oscillating rheometry
    J S Ungerstedt
    Department of Surgical Sciences, Karolinska Institutet, Stockholm, Sweden
    Scand J Clin Lab Invest 62:135-40. 2002
    ..in recalcified blood and plasma covariated with prothrombin time (PT) according to Owren, and activated partial thromboplastin time (aPTT)...
  100. ncbi Coagulation studies in preoperative neurosurgical patients
    B Schramm
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria
    Anaesth Intensive Care 29:388-92. 2001
    ..Preoperative test results (activated partial thromboplastin time [aPTT], prothrombin time [PT] and platelet count) and historical factors indicating a potential ..
  101. ncbi Novel thrombin inhibitors with azaphenylalanine scaffold
    A Zega
    Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
    Pharmazie 56:683-5. 2001
    ..By systematic structural modifications for this series we have identified optimal groups for achieving nanomolar potency, that led to potent inhibitors of thrombin with Ki values up to 11 nM...

Research Grants73

  1. Dual Direct Inhibitors of Thrombin and Factor Xa
    Umesh Desai; Fiscal Year: 2009
    ..at concentrations 2-6-fold below that of the clinically used LMWH enoxaparin, while in the activated partial thromboplastin time assay they required 2-6-fold higher concentration...
  2. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2010
    ..at concentrations 2-6-fold below that of the clinically used LMWH enoxaparin, while in the activated partial thromboplastin time assay they required 2-6-fold higher concentration...
  3. EFFECTS OF TF/FVIIa INHIBITION IN CRP TRANSGENIC MICE
    Christopher Arnold; Fiscal Year: 2004
    ..at different doses and efficacy will be determined by the effects on prothrombin time, activated partial thromboplastin time, platelet aggregation, and cyclic flow variations measured by Doppler flow...
  4. MECHANISMS OF VASCULAR DYSFUNCTION IN HOMOCYSTEINEMIA
    STEVEN LENTZ; Fiscal Year: 2003
    ..Aim 2, will test the hypothesis that vascular dysfunction in hyperhomocysteinemic mice is caused by increased oxidative stress in vivo. Aim 3 will attempt to determine the mechanisms of elevation of ADMA in hyperhomocysteinemia. ..
  5. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    STEVEN LENTZ; Fiscal Year: 2009
    ..The goals of this project are to define the molecular mechanisms by which hyperhomocysteinemia and hypercholesterolemia, alone or in combination, lead to adverse vascular events, and to identify new targets for therapy. ..
  6. MECHANISMS OF VASCULAR DYSFUNCTION IN HOMOCYSTEINEMIA
    STEVEN LENTZ; Fiscal Year: 2007
    ..This project has the potential to suggest novel therapeutic approaches to the prevention and treatment of vascular disease associated with hyperhomocysteinemia. ..
  7. Program in Hematology:& Cell Biology Blood Cells
    STEVEN LENTZ; Fiscal Year: 2007
    ....
  8. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    Steven R Lentz; Fiscal Year: 2010
    ..The goals of this project are to define the molecular mechanisms by which hyperhomocysteinemia and hypercholesterolemia, alone or in combination, lead to adverse vascular events, and to identify new targets for therapy. ..
  9. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
    ..This study will look at two methods of measuring these stem cells in the blood of heart patients. These methods may someday be used to predict who will or will not develop heart disease or other complications. ..
  10. Stabilized factor VIIIa as improved therapy for hemophilia A
    ANDREW GALE; Fiscal Year: 2007
    ..This treatment could improve the quality of life and overall health of the hemophilia A sufferers. ..
  11. Genetic Epidemiological Study of Venous Thromboembolism and Hemostatic Factors
    Weihong Tang; Fiscal Year: 2010
    ..The intermediate phenotypes include plasma levels of factor VIIIc, von Willebrand factor, and activated partial thromboplastin time. 3) To test for replication of significant genetic associations with VTE using a Mayo Clinic VTE study (..
  12. PROTEINS OF COAGULATION PATHWAYS
    John Griffin; Fiscal Year: 2007
    ..The proposed studies will increase our insights into the pathophysiology of thrombosis and are likely to improve diagnosis and treatment of thrombosis. ..
  13. Pharmacologic Prevention of Arteriovenous Graft Thrombosis
    Stephanie Perry; Fiscal Year: 2007
    ..Relevance: Patients must have vascular access for hemodialysis. Access complications account for 16- 25% of the hospital admissions for these patients, therefore contributing to both morbidity and health costs. ..
  14. FONDAPARINUM IN CHILDREN WITH THROMBOSIS
    Guy Young; Fiscal Year: 2007
    ..Pharmacokinetic analyses as well as safety and efficacy determinations will be made which will provide valuable information on this new anticoagulant for pediatric patients. ..
  15. STRUCTURE AND FUNCTION OF PROTEIN C
    John H Griffin; Fiscal Year: 2011
    ..The findings may well be translatable into future clinical advances. ..
  16. Chemical Modulation of Orphan Nuclear Receptor Function
    Sridhar Mani; Fiscal Year: 2010
    ..These studies will be vital for the generation on non-toxic compounds that antagonize PXR function - a tool necessary to probe PXR function in cells. ..
  17. STRUCTURE AND FUNCTION OF PROTEIN C
    John H Griffin; Fiscal Year: 2010
    ..The findings may well be translatable into future clinical advances. ..
  18. The role of hypoxia in venous neointimal hyperplasia in hemodialysis grafts
    Sanjay Misra; Fiscal Year: 2010
    ..The long term goal of this current proposal and research program is to improve the care of patients with ESRD, the vast majority of who use long-term hemodialysis as their mode of renal replacement therapy. ..
  19. Chemical Modulation of Orphan Nuclear Receptor Function
    Sridhar Mani; Fiscal Year: 2009
    ..These studies will be vital for the generation on non-toxic compounds that antagonize PXR function - a tool necessary to probe PXR function in cells. ..
  20. STRUCTURE AND FUNCTION OF PROTEIN C
    John Griffin; Fiscal Year: 2009
    ..These studies will improve our ability to understand, diagnose and treat thrombotic diseases. ..
  21. Voices of children and adolescents with incurable cancer on Phase I or II Trials
    Pamela S Hinds; Fiscal Year: 2010
    ..This study will allow us to measure direct symptom and quality of life reports of children and adolescents with incurable cancer who are receiving experimental drugs. ..
  22. MECHANISMS OF HORMONE THERAPY IN POSTMENOPAUSAL WOMEN
    L Newby; Fiscal Year: 2003
    ....
  23. PATHOGENIC MECHANISMS AND INTERVENTION STRATEGIES IN HUS
    Richard Siegler; Fiscal Year: 2002
    ....
  24. PROTEINS OF COAGULATION PATHWAYS
    John Griffin; Fiscal Year: 1999
    ..The proposed structure-function studies of protein S and of factor Va will contribute to our understanding of the pathophysiology of thrombosis and thereby eventually to the improved treatment of patients with thrombosis. ..
  25. PROTEINS OF COAGULATION PATHWAYS
    John Griffin; Fiscal Year: 1993
    ..These studies will provide new knowledge about natural anticoagulant mechanisms and will be potentially useful for developing new approaches to regulate thrombosis...
  26. PROTEINS OF COAGULATION PATHWAYS
    John Griffin; Fiscal Year: 2003
    ..The proposed studies of HDL, GlcCer, protein S and factor Va will increase our insights into the regulation of blood coagulation and thrombosis. ..
  27. Novel targets and agents to treat thrombotic disorders
    John Griffin; Fiscal Year: 2004
    ..abstract_text> ..
  28. Immune Thrombocytopenia and Low-Level Mercury Exposure
    Jodi Segal; Fiscal Year: 2006
    ..Segal with the necessary support for successful completion ..
  29. Enriched IVIG for the treatment of West Nile Virus
    Israel Nur; Fiscal Year: 2005
    ..In the absence of sufficient WN antibodies in convalescent donors, hyper-immune donors treated with an attenuated vaccine may be explored as an alternative source of plasma. ..
  30. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. ..
  31. PROTEINS OF COAGULATION PATHWAYS
    John H Griffin; Fiscal Year: 2010
    ..This project will increase insights into the pathophysiology of thrombosis and may improve diagnosis and treatment of thrombosis. ..
  32. STRUCTURE AND FUNCTION OF PROTEIN C
    John Griffin; Fiscal Year: 2007
    ..These studies will improve our ability to understand, diagnose and treat thrombotic diseases. ..
  33. Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in children
    Guy Young; Fiscal Year: 2009
    ..125 mg/kg/hour). Dose adjustments will be based on the activated partial thromboplastin time (aPTT) which will be the pharmacodynamic (PD) parameter measured...
  34. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..A novel technology, the use of nanoparticles to encapsulate the test drugs, will be tested to determine whether these nanoparticles can improve the delivery of drugs and minimize the associated toxicities. ..