lymphocyte count

Summary

Summary: The number of LYMPHOCYTES per unit volume of BLOOD.

Top Publications

  1. ncbi Lymphocyte homeostasis in HIV-infected northern Thais
    Doungnapa Kingkeow
    Research Institute for Health Sciences, Chiang Mai University, Thailand
    AIDS Res Hum Retroviruses 20:636-41. 2004
  2. ncbi Absolute lymphocyte count is a novel prognostic indicator in extranodal natural killer/T-cell lymphoma, nasal type
    J J Huang
    State Key Laboratory of Oncology in Southern China
    Ann Oncol 22:149-55. 2011
  3. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
  4. ncbi Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    Jeroen N Stoop
    Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    Hepatology 41:771-8. 2005
  5. ncbi Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice
    Joshua Kotner
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Infect Immun 75:861-9. 2007
  6. ncbi Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    Anders Wikby
    Department of Natural Science and Biomedicine, University College of Health Sciences, , Sweden
    Exp Gerontol 37:445-53. 2002
  7. ncbi Low absolute lymphocyte count is a poor prognostic factor in diffuse-large-B-cell-lymphoma
    Maria Christina Cox
    Department of Hematology, AO Sant Andrea, La Sapienza University, Rome, Italy
    Leuk Lymphoma 49:1745-51. 2008
  8. ncbi CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus
    Richard Stebbings
    Division of Immunology, NIBSC, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 79:12264-72. 2005
  9. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
  10. ncbi Absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric human immunodeficiency virus disease progression
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Infect Dis J 27:629-35. 2008

Research Grants

  1. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
  2. Non-CD4 Host defense against P. carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2010
  3. Opioid-Mediated Fas Expression in Lymphocyte Apoptosis
    Yufang Shi; Fiscal Year: 2005
  4. Psychological stress, cortisol, and B lymphocyte decrements
    Bonnie McGregor; Fiscal Year: 2007
  5. Immune Response to pneumococcal vaccination in HIV infected adults
    M A JULIA WESTERINK; Fiscal Year: 2010
  6. Iscar for Supplemental Care in Stage IV Lung Cancer
    Steven Rosenzweig; Fiscal Year: 2003
  7. CD8 AND GAMMA/DELTA T CELLS IN P CARINII PNEUMONIA
    Jay Kolls; Fiscal Year: 2002
  8. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2001
  9. NON CD4 HOST DEFENSE AGAINST P CARINII PNEUMONIA
    Jay Kolls; Fiscal Year: 2002
  10. PREVENTION OF PNEUMOCOCCAL DISEASE IN HIV INFECTION
    MARY MCELLISTREM; Fiscal Year: 2004

Detail Information

Publications187 found, 100 shown here

  1. ncbi Lymphocyte homeostasis in HIV-infected northern Thais
    Doungnapa Kingkeow
    Research Institute for Health Sciences, Chiang Mai University, Thailand
    AIDS Res Hum Retroviruses 20:636-41. 2004
    Cross-sectional laboratory data were used to model the patterns of total lymphocyte count and lymphocyte subpopulation counts among persons with chronic HIV-1 subtype E (CRF01_AE) infection during the 6.5 years preceding death...
  2. ncbi Absolute lymphocyte count is a novel prognostic indicator in extranodal natural killer/T-cell lymphoma, nasal type
    J J Huang
    State Key Laboratory of Oncology in Southern China
    Ann Oncol 22:149-55. 2011
    extranodal natural killer (NK)/T-cell lymphoma (ENKL) is a heterogeneous entity with poor survival, requiring risk stratification in affected patients. We proposed absolute lymphocyte count (ALC) as a new prognostic factor in ENKL.
  3. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
    ..These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses...
  4. ncbi Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    Jeroen N Stoop
    Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    Hepatology 41:771-8. 2005
    ..T(reg) have an immunosuppressive effect on HBV-specific T helper cells. The presence of HBV-specific T(reg) could contribute to an inadequate immune response against the virus, leading to chronic infection...
  5. ncbi Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice
    Joshua Kotner
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Infect Immun 75:861-9. 2007
    ..cruzi infection...
  6. ncbi Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    Anders Wikby
    Department of Natural Science and Biomedicine, University College of Health Sciences, , Sweden
    Exp Gerontol 37:445-53. 2002
    ..As in the OCTO study, the NONA-Immune data indicated that the changes are associated significantly with seropositive responses to CMV...
  7. ncbi Low absolute lymphocyte count is a poor prognostic factor in diffuse-large-B-cell-lymphoma
    Maria Christina Cox
    Department of Hematology, AO Sant Andrea, La Sapienza University, Rome, Italy
    Leuk Lymphoma 49:1745-51. 2008
    ..018; p < 0.00001). Our data, show that ALC at diagnosis has a strong prognostic relevance and is independent from the R-IPI. The new score including both values proved the most powerful predictor at multivariate analysis...
  8. ncbi CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus
    Richard Stebbings
    Division of Immunology, NIBSC, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 79:12264-72. 2005
    ....
  9. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  10. ncbi Absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric human immunodeficiency virus disease progression
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Infect Dis J 27:629-35. 2008
    ..We assessed the use of absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric HIV disease progression.
  11. ncbi The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma
    J H Lee
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, China
    Clin Exp Immunol 148:53-63. 2007
    ..With increased expression of FoxP3 and IL-10 in T(reg) from patients with relatively severe allergic disease, adaptive and functional T(reg) might be generated in response to aggravated atopy and disease severity...
  12. ncbi Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies
    Guillermo De Angulo
    Division of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 112:407-15. 2008
    ..The prognostic significance of absolute lymphocyte counts (ALC) was evaluated in young patients with acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL)...
  13. ncbi SHIP limits immunoregulatory capacity in the T-cell compartment
    Michelle M Collazo
    Department of Immunology, Moffitt Comprehensive Cancer Center and Research Institute, Tampa, FL, USA
    Blood 113:2934-44. 2009
    ..These findings further define the immunosuppressive mechanisms that result from SHIP deficiency and provide additional justification for targeting SHIP in clinical transplantation...
  14. ncbi Changes in total lymphocyte count as a surrogate for changes in CD4 count following initiation of HAART: implications for monitoring in resource-limited settings
    Anish P Mahajan
    School of Medicine, Brown University, Providence, RI, 02906, USA
    J Acquir Immune Defic Syndr 36:567-75. 2004
    ..The total lymphocyte count (TLC) has been proposed as a surrogate marker to monitor immune response to therapy...
  15. ncbi Lymphopenia assessed during routine follow-up after immunochemotherapy (R-CHOP) is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma
    L F Porrata
    Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Leukemia 24:1343-9. 2010
    ..Thus, we studied absolute lymphocyte count (ALC) as a marker of poststandard chemotherapy (rituximab, cyclophosphamide, adriamycin, vincristine and ..
  16. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Our results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments...
  17. ncbi Absolute lymphocyte counts predicts response to chemotherapy and survival in diffuse large B-cell lymphoma
    D H Kim
    Leukemia 21:2227-30. 2007
  18. ncbi Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T cells
    Hanna Grindebacke
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy, University of Gothenburg, Box 480, Goteborg 405 30, Sweden
    J Immunol 183:4360-70. 2009
    ..These findings suggest that the gut is the primary site of Treg stimulation to exogenous Ags during the first 18 mo of life and that homing receptor switch toward a more extra-intestinal phenotype occurs thereafter...
  19. ncbi The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy
    Xia Wu
    Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China
    Cancer Immunol Immunother 59:279-91. 2010
    ..It is probable that the "window" period of days 12-14 after chemotherapy provides the best opportunity for immunotherapy...
  20. ncbi Evidence for translocation of microbial products in patients with idiopathic CD4 lymphocytopenia
    Philip I Lee
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 199:1664-70. 2009
    ..These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection...
  21. ncbi Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge
    Bapi Pahar
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    Virology 387:273-84. 2009
    ..These results suggest that protection against pathogenic lentiviral infection or disease progression is indeed possible, and may correlate with preservation of mucosal CD4(+) T cells...
  22. ncbi Population-based hematologic and immunologic reference values for a healthy Ugandan population
    Eric S Lugada
    Center for International Health, University of Bergen, Bergen, Norway
    Clin Diagn Lab Immunol 11:29-34. 2004
    ..These differences could influence the decision to initiate antiretroviral therapy among children infected with HIV...
  23. ncbi Impaired expansion of mouse B cell progenitors lacking Btk
    J D Kerner
    Department of Immunology, University of Washington, Seattle 98195, USA
    Immunity 3:301-12. 1995
    ..Our results suggest that the murine and human consequences of Btk deficiency differ only quantitatively, and represent the same disease process...
  24. ncbi Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival
    Kazuhiko Ino
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 14:2310-7. 2008
    ..The purpose of the present study was to investigate the relationship between IDO expression and tumor-infiltrating lymphocytes (TIL) or natural killer (NK) cells and to clarify their prognostic effect in endometrial cancer...
  25. ncbi Duration of humoral immunity to common viral and vaccine antigens
    Ian J Amanna
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    N Engl J Med 357:1903-15. 2007
    ..Maintenance of long-term antibody responses is critical for protective immunity against many pathogens. However, the duration of humoral immunity and the role played by memory B cells remain poorly defined...
  26. ncbi Absolute lymphocyte count predicts therapeutic efficacy of rituximab therapy in follicular lymphomas
    Deepti Behl
    Division of Hematology Department Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Br J Haematol 137:409-15. 2007
    ..Thus, we studied the role of absolute lymphocyte count (ALC) prior to rituximab therapy on treatment efficacy and TTP in FL patients...
  27. ncbi Impact of peripheral lymphocyte count on the sensitivity of 2 IFN-gamma release assays, QFT-G and ELISPOT, in patients with pulmonary tuberculosis
    Kosaku Komiya
    Department of Pulmonary Medicine, Tokyo National Hospital, Tokyo, Japan
    Intern Med 49:1849-55. 2010
    This study evaluated the effect of peripheral lymphocyte count on 2 interferon-gamma release assays [QuantiFERON TB-Gold (QFT-G) and enzyme-linked immunospot (ELISPOT)] and their sensitivity in patients with pulmonary tuberculosis, ..
  28. ncbi Total lymphocyte count of 1200 is not a sensitive predictor of CD4 lymphocyte count among patients with HIV disease in Kampala, Uganda
    Moses R Kamya
    Makerere University Medical School, Kampala, Uganda
    Afr Health Sci 4:94-101. 2004
    Total Lymphocyte Count (TLC) has been found to be an inexpensive and useful marker for staging disease, predicting progression to AIDS and death and monitoring response to ART...
  29. ncbi Positive association between total lymphocyte count and femur bone mineral density in hip-fractured women
    Marco Di Monaco
    Osteoporosis Research Centre, Presidio Sanitario San Camillo, Strada Santa Margherita 136, I 10131 Turin, Italy
    Gerontology 48:157-61. 2002
    ..Protein depletion appears to play a detrimental role in the causes of hip fracture and low bone mineral density has been observed in protein-depleted subjects...
  30. ncbi Total lymphocyte count, hemoglobin, and delayed-type hypersensitivity as predictors of death and AIDS illness in HIV-1-infected women receiving highly active antiretroviral therapy
    Kathryn Anastos
    Women s Interagency HIV Study, Montefiore Medical Center, Bronx, NY 10467, USA
    J Acquir Immune Defic Syndr 35:383-92. 2004
    Total lymphocyte count (TLC) and hemoglobin level have been suggested as useful and inexpensive parameters to indicate need for HAART in settings in which CD4 cell counts are unavailable...
  31. ncbi Absolute lymphocyte count predicts overall survival in follicular lymphomas
    Mustaqeem Siddiqui
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 134:596-601. 2006
    The peripheral blood absolute lymphocyte count (ALC) recovery after autologous stem cell transplantation has been shown to be an independent prognostic factor for survival for different haematologic malignancies...
  32. ncbi Use of total lymphocyte count for monitoring response to antiretroviral therapy
    Tanya Schreibman
    Yale University School of Medicine, AIDS Program, Yale New Haven Hospital, New Haven, Connecticut 06510, USA
    Clin Infect Dis 38:257-62. 2004
    ..The data regarding the clinical utility of the total lymphocyte count (TLC) as a potential surrogate marker of immune function in patients with HIV disease are examined...
  33. ncbi Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    Udaya K Liyanage
    Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Immunol 169:2756-61. 2002
    ..These T(reg) may mitigate the immune response against cancer, and may partly explain the poor immune response against tumor Ags...
  34. ncbi Total lymphocyte count (TLC) is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries
    N Kumarasamy
    Y R G Centre for AIDS Research and Education, Chennai, India
    J Acquir Immune Defic Syndr 31:378-83. 2002
    ..OBJECTIVES To evaluate the correlation of total lymphocyte count (TLC), an inexpensive and widely available parameter, to CD4 count...
  35. ncbi Total lymphocyte count and femoral bone mineral density in postmenopausal women
    Marco Di Monaco
    Presidio Sanitario San Camillo, Osteoporosis Research Centre, Strada Santa Margherita 136, IT 10131, Turin, Italy
    J Bone Miner Metab 22:58-63. 2004
    ..Our aim was to evaluate the association between total lymphocyte count (TLC) and femoral bone mineral density (BMD) in a sample of postmenopausal women...
  36. ncbi Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy
    Mark A Jacobson
    Positive Health Program, Department of Medicine, University of California, San Francisco, USA
    AIDS 17:917-9. 2003
  37. ncbi Methotrexate-induced lung injury in patients with rheumatoid arthritis occurs with peripheral blood lymphocyte count decrease
    S Inokuma
    Ann Rheum Dis 65:1113-4. 2006
  38. ncbi Predicting CD4 lymphocyte count <200 cells/mm(3) in an HIV type 1-infected African population
    Susan C Morpeth
    Duke University Medical Center, Durham, North Carolina, 27710, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    AIDS Res Hum Retroviruses 23:1230-6. 2007
    ..of WHO staging criteria, anthropometrics, and simple laboratory measurements for predicting CD4 lymphocyte count (CD4 count) <200 cells/mm(3) among HIV-infected patients in Tanzania...
  39. ncbi Hyper innate responses in neonates lead to increased morbidity and mortality after infection
    Jie Zhao
    Center for Infection and Immunity and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Proc Natl Acad Sci U S A 105:7528-33. 2008
    ..Therefore, neonates might suffer from the unleashed innate responses caused by an insufficient number of T cells, which leads to increased morbidity and mortality...
  40. ncbi Low absolute lymphocyte count is a poor prognostic marker in patients with diffuse large B-cell lymphoma and suggests patients' survival benefit from rituximab
    Yasuhiro Oki
    Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan
    Eur J Haematol 81:448-53. 2008
    To evaluate the prognostic value of absolute lymphocyte count (ALC) at diagnosis in patients with diffuse large B-cell lymphoma (DLBCL).
  41. ncbi Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections
    R J Hogan
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 166:1813-22. 2001
    ..The kinetics of persistence of Ag-specific CD8(+) T cells in the lung suggests that they play a key role in protective cellular immunity to respiratory virus infections...
  42. ncbi Protein-bound polysaccharide increases survival in resected gastric cancer cases stratified with a preoperative granulocyte and lymphocyte count
    T Toge
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima City, Hiroshima 734 0037, Japan
    Oncol Rep 7:1157-61. 2000
    ..In 751 patients who underwent macroscopically curative resection preoperative granulocyte and lymphocyte count ratios (G/L) were measured. These patients were stratified with a preoperative cut-off of G/L:2...
  43. ncbi Absolute lymphocyte count is a prognostic factor in diffuse large B-cell lymphoma
    M Christina Cox
    Br J Haematol 141:265-8. 2008
  44. ncbi A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis
    Johnson Ho
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 180:2573-80. 2008
    ..These inflammation-driven populations exert distinct roles during the development of chronic ileitis, and influence the balance of effector and regulatory functions in the chronically inflamed small intestine...
  45. ncbi Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival
    Geoffrey Y Ku
    Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 116:1767-75. 2010
    ..The authors report on advanced refractory melanoma patients treated in a compassionate use trial of ipilimumab at the Memorial Sloan-Kettering Cancer Center...
  46. ncbi Lymphopenia as a prognostic factor in patients with peripheral T-cell lymphoma, unspecified
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    Leuk Lymphoma 51:1822-8. 2010
    ..The aim of our study was to retrospectively evaluate the presence of lymphopenia, defined as a lymphocyte count of<1000 cells/mm³, as a prognostic factor for survival in patients with PTCLU...
  47. ncbi Absolute lymphocyte count at the time of first relapse predicts survival in patients with diffuse large B-cell lymphoma
    Luis F Porrata
    Division of Hematology Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Hematol 84:93-7. 2009
    Peripheral blood absolute lymphocyte count (ALC) is a survival prognostic factor in hematological malignancies. No reports have addressed whether ALC at the time of first relapse (ALC-R) predicts survival...
  48. ncbi Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children
    Philippa M Musoke
    Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 49:171-8. 2008
    To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %.
  49. ncbi CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study
    Gilbert R Kaufmann
    Basel Center for HIV Research, Division of Infectious Diseases, University Hospital, Basel, Switzerland
    Arch Intern Med 163:2187-95. 2003
    ..The CD4 T-lymphocyte count increase, the percentage of individuals with a CD4 T-lymphocyte count of 500/microL or greater and less than ..
  50. ncbi Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis
    T Chiba
    Division of Advanced Surgical Science and Technology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Cancer 91:1711-7. 2004
    ..In conclusion, our data support a hypothesis on the presence of systemic immunosurveillance against micrometastasis of cancer cells...
  51. ncbi Cutting edge: programmed death-1 up-regulation is involved in the attrition of cytomegalovirus-specific CD8+ T cells in acute self-limited hepatitis B virus infection
    Ji Yuan Zhang
    Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
    J Immunol 181:3741-4. 2008
    ..Thus, PD-1 plays a crucial role in the attrition of CMV-specific CD8(+) T cells in acute hepatitis B virus infection, which in turn, influences the preexisting homeostatic virus-specific CD8(+) T cell pool...
  52. ncbi Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 174:5110-8. 2005
    ..Lymphocyte loss occurs by both death receptor and mitochondrial-mediated apoptosis, suggesting that there may be multiple triggers for lymphocyte apoptosis...
  53. ncbi Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma
    A O Magnan
    UPRES 2050, Groupe de Recherche Clinique Pathologie respiratoire et cutanée liée à l environnement, Service de pneumo allergologie, et Centre d Investigations Cliniques, INSERM, Assistance Publique Hopitaux de Marseille, France
    Am J Respir Crit Care Med 161:1790-6. 2000
    ..In addition, this number was correlated to IL-12 production. These results show that in addition to the well-known Th2 inflammation in asthma, there are IFN-gamma-producing CD8(+) T cells in the blood, possibly controlled by IL-12...
  54. ncbi The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
    A Cariappa
    Cancer Center and, Massachusetts General Hospital and, Harvard Medical School, Boston, MA 02129, USA
    Immunity 14:603-15. 2001
    ..These data support the view that antigens (in contrast to "tonic" signals) drive the development of naive B cells...
  55. ncbi Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer
    Khaled M Sarraf
    Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 137:425-8. 2009
    ..We sought to determine factors associated with increasing neutrophil/lymphocyte ratios and the stage-adjusted prognostic effect in patients undergoing resection for non-small cell lung cancer...
  56. ncbi Treatment of psoriasis with alefacept: correlation of clinical improvement with reductions of memory T-cell counts
    Kenneth B Gordon
    Department of Medicine, Division of Dermatology, Loyola University Medical Center, Maywood, IL 60153, USA
    Arch Dermatol 139:1563-70. 2003
    ..To examine the relationship between the pharmacodynamic and antipsoriatic effects of alefacept, a biologic agent that targets CD4+ and CD8+ memory T cells...
  57. ncbi Recurrent cytomegalovirus retinitis in a patient with a normal lymphocyte count who had undergone splenectomy for lymphoma
    Brendan Vote
    Department of Ophthalmology, University of Auckland, Auckland, New Zealand
    Retina 25:220-1. 2005
  58. ncbi Resource competition determines selection of B cell repertoires
    R J De Boer
    Theoretical Biology, Utrecht University, The Netherlands
    J Theor Biol 212:333-43. 2001
    ....
  59. ncbi Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis
    E Gamble
    Department of Respiratory Medicine, London Chest Hospital, Bonner Road, London, UK
    Eur Respir J 30:467-71. 2007
    ..It is concluded that, in established chronic obstructive pulmonary disease, the bronchial mucosal inflammatory cell infiltrate is similar in ex-smokers and those that continue to smoke...
  60. ncbi Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    Junzo Hamanishi
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 104:3360-5. 2007
    ..A significant inverse correlation was observed between PD-L1 expression and the intraepithelial CD8(+) T lymphocyte count, suggesting that PD-L1 on tumor cells directly suppresses antitumor CD8(+) T cells...
  61. ncbi Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    J Immunol 166:6952-63. 2001
    ..Similar loss of lymphocytes may be occurring in critically ill patients with other disorders...
  62. ncbi Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP)
    Yoshihisa Yamano
    Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Blood 99:88-94. 2002
    ..These data suggest that increased HTLV-1 expression plays an important role in the pathogenesis of HAM/TSP, and the HTLV-1 tax mRNA level could be a useful predictor of disease progression in patients with HAM/TSP...
  63. ncbi Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    M E Brunkow
    Celltech Chiroscience, Inc, Bothell, Washington, USA
    Nat Genet 27:68-73. 2001
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis...
  64. ncbi Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents
    F Hildebrand
    Hannover Medical School, Trauma Department, Hannover, Germany
    Clin Exp Immunol 138:221-9. 2004
    ..Our study suggests that NK cells are involved in the protective mechanism of DHEA in WT mice. It would therefore seem that DHEA represents a feasible alternative therapy for the dysregulated immune system in sepsis...
  65. ncbi [Immunologically-competent cells in liver infiltrating lymphocytes in patients with chronic severe hepatitis B]
    Zheng Sheng Zou
    No 4 Department of Infectious Diseases, Hospital No 302 of Chinese People s Liberation Army, Beijing 100039, China
    Zhonghua Yi Xue Za Zhi 87:2416-9. 2007
    ..To investigate the frequencies of immunologically competent cells (ICCs) in the liver-infiltrating lymphocytes (LILs) and peripheral blood and their possible role in pathogenesis in patients with chronic severe hepatitis B (CSHB)...
  66. ncbi The number of CD8+ T cells and NKT cells increases in the aqueous humor of patients with Behçet's uveitis
    H G Yu
    Department of Ophthalmology, Seoul Artificial Eye Centre, Seoul National University Hospital Clinical Research Institute, Seoul, Korea
    Clin Exp Immunol 137:437-43. 2004
    ..05). These results suggest that the immunopathogenesis of endogenous uveitis can vary between syndromes, and that CD8+CD56+ NKT cells may play an important role in the immunopathogenesis of Behçet's uveitis...
  67. ncbi Immunohematological reference values for healthy adults in Burkina Faso
    N Klose
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Clin Vaccine Immunol 14:782-4. 2007
    ..CD4(+) T-cell counts ranged from 631 to 1,696 cells microl(-1); they were lower in males (n = 97) than in females (n = 89), whereas natural killer cell counts were higher...
  68. ncbi Evaluation of a simplified dual-platform flow cytometric method for measurement of lymphocyte subsets and T-cell maturation phenotypes in the population of Nouna, Burkina Faso
    T Bohler
    Department of Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Clin Vaccine Immunol 14:775-81. 2007
    ..Among CD8(bright) lymphocytes, 3% +/- 2% had a central memory phenotype, 27% +/- 13% were naïve, 37% +/- 13% had an effector memory phenotype, and 34% +/- 12% were terminally differentiated effector memory cells expressing CD45RA...
  69. ncbi Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Endocrinol Metab 290:E856-63. 2006
    ..In addition, sex steroids suppress NK cell proliferation. This study supports a complex physiological role for T and/or its metabolites in immune regulation...
  70. ncbi Prolongation of allograft survival in ccr7-deficient mice
    Jan H Beckmann
    Department of Visceral and Transplantation Surgery, Hannover Medical School, 30625 Hannover, Germany
    Transplantation 77:1809-14. 2004
    ..Because CCR7 is the essential chemokine receptor responsible for lymphocyte and dendritic cell homing to secondary lymphoid organs, allograft survival was analyzed in CCR7-deficient (CCR7) mice...
  71. ncbi Augmentation of virus-specific immunity after hematopoietic stem cell transplantation by adoptive T-cell therapy
    Karl S Peggs
    Department of Haematology, Royal Free and University College London Medical School, London, United Kingdom
    Hum Immunol 65:550-7. 2004
    ..This simple in vitro methodology should allow widespread application of adoptive transfer of virus-specific T cells...
  72. ncbi Lymphocyte numbers and function in relation to periodontitis and smoking
    Bruno G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands
    J Periodontol 75:557-64. 2004
    ..Taking smoking into consideration, the aim of this study was to analyze numbers of circulating T (CD3+) cells and their CD4+ and CD8+ subpopulations, B (CD19+) cells, and T-cell proliferative capacity in periodontitis...
  73. ncbi Immune cell variations in patients with hip fracture
    Felícito García-Álvarez
    Department of Traumatology, University Clinical Hospital Lozano Blesa, Avda San Juan Bosco 15, 50009 Zaragoza, Spain
    Arch Gerontol Geriatr 46:117-24. 2008
    ..Basophils percentage presented an inverse correlation with age. Age is associated to some immune changes in patients suffering hip fracture...
  74. ncbi Thymic function and impaired maintenance of peripheral T cell populations in children with congenital heart disease and surgical thymectomy
    Nancy J Halnon
    Division of Pediatric, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Pediatr Res 57:42-8. 2005
    ..especially if they include thymectomy, impair T-cell production and produce long-term decreases in total lymphocyte count and CD4(+) and CD8(+) T-cell subsets, suggesting that long-term maintenance of lymphocyte populations is ..
  75. ncbi Humoral and cellular immune responses in children given annual immunization with trivalent inactivated influenza vaccine
    Alenka M Zeman
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatr Infect Dis J 26:107-15. 2007
    ..There have been no prior reports of the frequency of circulating influenza-specific, interferon gamma-producing memory CD4+ and CD8+ T-cells in healthy children who have received multiple influenza immunizations...
  76. ncbi Pharmacokinetic/pharmacodynamic modeling of total lymphocytes and selected subtypes after oral budesonide
    Jeffrey G Stark
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, 32610, USA
    J Pharmacokinet Pharmacodyn 33:441-59. 2006
    ....
  77. ncbi Cytometric analysis of BAL T cells labeled with a standardized antibody cocktail correlates with immunohistochemical staining
    Patricia A Smith
    Pulmonary Division, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cytometry B Clin Cytom 70:170-8. 2006
    ....
  78. ncbi Hyporesponsiveness of T cell subsets after cardiac surgery: a product of altered cell function or merely a result of absolute cell count changes in peripheral blood?
    Axel Franke
    Department of Cardiovascular Surgery, Bundeswehr Central Hospital, Rübenacher Str 170, D 56072 Koblenz, Germany
    Eur J Cardiothorac Surg 30:64-71. 2006
    ..We conducted a prospective study in order to test the hypothesis that the decrease in specific immunity is not caused by dilution effects but by functional alterations in T cell subsets...
  79. ncbi Naïve T-cell dynamics in human immunodeficiency virus type 1 infection: effects of highly active antiretroviral therapy provide insights into the mechanisms of naive T-cell depletion
    Michele Di Mascio
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700 B Rockledge Drive, MSC 7609, Bethesda, MD 20892, USA
    J Virol 80:2665-74. 2006
    ..These observations are consistent with a mathematical model where the HIV-1-induced increase in proliferation of naïve T cells is mostly explained by a faster recruitment into memory cells...
  80. ncbi Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: a flow cytometric analysis
    Abbie C Connoy
    Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University Health Sciences, 100 Medical Center Blvd, Winston Salem, NC 27157-1042, USA
    Exp Gerontol 41:225-9. 2006
    ..The senescence marker p16INK4a increases in B cells and CD8+T cells within the spleen and can be measured by flow cytometry...
  81. ncbi Are increased frequency of macrophage-like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas' disease morbidity?
    D M Vitelli-Avelar
    Laboratório de Doença de Chagas, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
    Clin Exp Immunol 145:81-92. 2006
    ....
  82. ncbi Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    Eiji Suzuki
    Thoracic Oncology Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Cancer Res 11:6713-21. 2005
    ..CONCLUSIONS: These results suggest that gemcitabine may be a practical strategy for the reduction of myeloid suppressor cells and should be evaluated in conjunction with a variety of immunotherapy approaches...
  83. ncbi Detailed analysis of Epstein-Barr virus-specific CD4+ and CD8+ T cell responses during infectious mononucleosis
    J Scherrenburg
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Immunol 153:231-9. 2008
    ....
  84. ncbi Immunologic features of HIV-1-infected women on HAART at delivery
    Erika Ono
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil
    Cytometry B Clin Cytom 74:236-43. 2008
    ..The conjoint effect of HIV infection and pregnancy on the immune system of women submitted to the prophylactic antiretroviral therapy presently recommended is still poorly understood...
  85. ncbi Lymphocyte subsets' reference ranges in an age- and gender-balanced population of 100 healthy adults--a monocentric German study
    Kathleen Jentsch-Ullrich
    Department of Haematology Oncology, Medical Faculty, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Clin Immunol 116:192-7. 2005
    ..Based on these results, we established reference values for three subgroups: males < or = 50 years, females < or = 50 years, and males/females > 50 years...
  86. ncbi Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infection
    John S Lambert
    Institute of Human Virology, University of Maryland, Baltimore, USA
    Clin Diagn Lab Immunol 12:622-31. 2005
    ..Detailed immunophenotyping may be useful in supporting the diagnosis of HIV infection in infants with perinatal HIV exposure...
  87. ncbi [Lymphocyte populations and subpopulations in peripheral blood of pregnant women with pre-eclampsia]
    E Dimitrakova-Dzhambazova
    Akush Ginekol (Sofiia) 44:40-4. 2005
    ..blood of 37 pregnant women, of whom 12 had preeclampsia and 25 had normal pregnancy pespectively: Total lymphocyte count CD19+ (B-lymphocytes), CD2+ (Total T-lymphocytes), CD3+ (Immunocompetent T-lymphocytes) CD3+CD4+ (T-helpers), ..
  88. ncbi Mathematically modeling dynamics of T cell responses: predictions concerning the generation of memory cells
    Brynja Kohler
    Department of Mathematics and Statistics, Utah State University, 3900 Old Main Hill, Logan, UT 84322, USA
    J Theor Biol 245:669-76. 2007
    ..We also propose a method of distinguishing the models by examining the ratio of memory T cells detectable long after an infection to the peak numbers of T cells at the end of the expansion phase...
  89. ncbi Low-dose interleukin-2 administered pre-operatively to patients with gastric cancer activates peripheral and peritumoral lymphocytes but does not affect prognosis
    Giovanni Carlo Cesana
    Department of General Surgery, University of Milano Bicocca, S Gerardo Hospital, via Donizzetti 106, Monza, 20052 Milan, Italy
    Ann Surg Oncol 14:1295-304. 2007
    ..The aim of this randomized case-control study is to evaluate the effects of pre-operative low-dose IL-2 treatment on patients with gastric adenocarcinoma who undergo surgery...
  90. ncbi A combined HIV-1 protein bead array for serology assay and T-cell subset immunophenotyping with a hybrid flow cytometer: a step in the direction of a comprehensive multitasking instrument platform for infectious disease diagnosis and monitoring
    Sylvie Faucher
    National HIV Immunology Laboratory, National HIV and Retrovirology Laboratories, Public Health Agency of Canada, Ottawa, Ontario
    Cytometry B Clin Cytom 70:179-88. 2006
    ..These hybrid instruments provide an opportunity for the development of a more cost effective multitasking platform to support infectious disease treatment in resource limited countries...
  91. ncbi Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients
    M Feuerer
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 92:96-105. 2001
    ..The overall results reveal that BM is a valuable additional compartment for immune diagnosis in pathological conditions and possibly for follow-up treatment strategies...
  92. ncbi Intestinal T lymphocytes of different rat strains in immunotoxicity
    M C Bruder
    TNO Nutrition and Food Research Institute, Department of General Toxicology, Zeist, The Netherlands
    Toxicol Pathol 27:171-9. 1999
    ..The data indicate that the intraepithelial lymphocytes in the intestines are a potential target for orally administered immunomodulating compounds and should therefore receive more attention in toxicologic pathology studies...
  93. ncbi Dynamics of T cell responses in HIV infection
    Victor Appay
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:3660-6. 2002
    ..These observations have significant implications for our understanding of T cell responses in human viral infections in general and indicate that the definition of effector and memory subsets in humans may need revision...
  94. ncbi Immunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculosis infection and disease
    D S S Rodrigues
    Infectious Diseases Discipline and Immunization Center, , , Brazil
    Clin Exp Immunol 128:149-54. 2002
    ..tuberculosis...
  95. ncbi The transcription factor NFAT4 is involved in the generation and survival of T cells
    M Oukka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 9:295-304. 1998
    ..Further, mice lacking NFAT4 have impaired production of Bcl-2 mRNA and protein. NFAT4 thus plays an important role in the successful generation and survival of T cells...
  96. ncbi Lymphocyte subset pattern in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 25:125-8. 2002
    ..These data further support the existence of abnormalities of the immune system in patients with chronic GH/IGF-1 excess...
  97. ncbi Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis
    Dirk Schluter
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    J Immunol 169:315-22. 2002
    ..In chronic TE, T cell recruitment is terminated, the phenotype of intracerebral T cells changes, and their number is gradually downsized by low level apoptosis, which, however, does not completely resolve the T cell infiltrates...
  98. ncbi Deficiencies in CD4+ and CD8+ T cell subsets in ataxia telangiectasia
    R Schubert
    Department of Paediatrics, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Clin Exp Immunol 129:125-32. 2002
    ..Taken together, our results suggest that deficiency of immunocompetent cells and an intrinsic immune activation defect are responsible for the immunodeficiency in AT...
  99. ncbi Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    Heiner Wedemeyer
    Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3447-58. 2002
    ..Thus, the defective functions of HCV-specific CD8+ T cells might contribute to viral persistence in chronically infected patients, and knowledge on their reversibility may facilitate the development of immunotherapeutic vaccines...
  100. ncbi T cell-mediated elimination of B7.2 transgenic B cells
    S Fournier
    Department of Molecular and Cellular Biology, University of California at Berkeley, 94720, USA
    Immunity 6:327-39. 1997
    ..2 transgenic B cells are not eliminated, but proliferate and differentiate normally. Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system participates in the regulation of B cell homeostasis...
  101. ncbi Lymphocyte subpopulations in breast-fed and formula-fed infants at six months of age
    J S Hawkes
    Department of Paediatrics and Child Health, The Flinders University of South Australia, Bedford Park, Australia
    Adv Exp Med Biol 501:497-504. 2001
    ..4 in formula-fed infants (P < 0.001). Conclusion: Breast-fed infants (<250mL formula/bovine milk per week) had a greater proportion of NK cells and a lower CD4 to CD8 ratio than formula-fed infants at 6 months of age...

Research Grants71

  1. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..women with (cases) and without (control) elevated breastmilk sodium were matched by plasma HIV load and CD4+ lymphocyte count. Cases has a median breastmilk HIV load of 1765 copies/mL compared with undetectable load in controls (p less ..
  2. Non-CD4 Host defense against P. carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2010
    ..The well-known inverse relationship between CD4+ lymphocyte count and the risk of PC infection does not hold all of the answers to mechanisms of host defense against this ..
  3. Opioid-Mediated Fas Expression in Lymphocyte Apoptosis
    Yufang Shi; Fiscal Year: 2005
    ..The results should lead to an understanding of the effects of space flight environment on human immune system. ..
  4. Psychological stress, cortisol, and B lymphocyte decrements
    Bonnie McGregor; Fiscal Year: 2007
    ..The present study will begin to elucidate the mechanism by which psychological stress impairs immune response to vaccines. ..
  5. Immune Response to pneumococcal vaccination in HIV infected adults
    M A JULIA WESTERINK; Fiscal Year: 2010
    ..the vaccine is less than optimal and correlates with the degree of immune suppression as measured by CD4+ T-lymphocyte count (1-10)...
  6. Iscar for Supplemental Care in Stage IV Lung Cancer
    Steven Rosenzweig; Fiscal Year: 2003
    ..a.) will increase markers of immune function (as determined by total lymphocyte count, eosinophil count, and lymphocyte subset analysis), AND (l.b...
  7. CD8 AND GAMMA/DELTA T CELLS IN P CARINII PNEUMONIA
    Jay Kolls; Fiscal Year: 2002
    ..Although there is a well-known relationship between CD4+ lymphocyte count and the risk of PC infection, the role of mononuclear phagocytes, CD8+ cells, gamma/delta T cells, and their ..
  8. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2001
    ..cellular immunity function will be accurate predictors for endodontic success or failure, and that the CD4 lymphocyte count alone is an inadequate base for making such decisions...
  9. NON CD4 HOST DEFENSE AGAINST P CARINII PNEUMONIA
    Jay Kolls; Fiscal Year: 2002
    ..Although there is a well-known relationship between CD4+ lymphocyte count and the risk of PC infection, the role of mononuclear phagocytes, CD8+ cells, NK cells, and their secreted ..
  10. PREVENTION OF PNEUMOCOCCAL DISEASE IN HIV INFECTION
    MARY MCELLISTREM; Fiscal Year: 2004
    ..concentrations will be analyzed by logistic regression to assess the effect of initial viral load and CD4 lymphocyte count. All patients who exhibit a greater that 3-fold transient rise in HIV-1 RNA levels 2 and 4 weeks ..
  11. T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    John Fahy; Fiscal Year: 2004
    ..abstract_text> ..
  12. Novel MRS Methods to Characterize MCMD
    Karl Goodkin; Fiscal Year: 2007
    ..disorder (MCMD)] and pathophysiological indices (plasma HIV-1 RNA load; CD4 cell count; cytotoxic T lymphocyte count)...
  13. The Utility of Interferon-Gamma Release Assays in TB-HIV co-infected Children
    Anna Mandalakas; Fiscal Year: 2007
    ..A focused set of standardized measures of age, nutrition and HIV-related immune status (CD4 T lymphocyte count) will be collected to fully assess their effect on the TST and IGRAs...
  14. Clinical Algorithms to Monitor HIV Treatment in Uganda
    Lisa Spacek; Fiscal Year: 2007
    ..The initiation and monitoring of ART are guided by algorithms that combine clinical symptoms, CD4 lymphocyte count, and HIV viral load...
  15. PREVENTION OF HIV SHEDDING IN WOMEN--TRIAL OF VITAMIN A
    Julie Overbaugh; Fiscal Year: 2003
    ..In addition, venous blood will be obtained at the two time points for quantification of plasma HIV-1 RNA, CD4 lymphocyte count, and serum vitamin A levels...
  16. PREVENTION OF HIV SHEDDING IN WOMEN--TRIAL OF VITAMIN A
    Joan Kreiss; Fiscal Year: 2001
    ..In addition, venous blood will be obtained at the two time points for quantification of plasma HIV-1 RNA, CD4 lymphocyte count, and serum vitamin A levels...
  17. The Utility of Interferon-Gamma Release Assays in TB-HIV co-infected Children
    Anna M Mandalakas; Fiscal Year: 2010
    ..A focused set of standardized measures of age, nutrition and HIV-related immune status (CD4 T lymphocyte count) will be collected to fully assess their effect on the TST and IGRAs...