lymphocyte count

Summary

Summary: The number of LYMPHOCYTES per unit volume of BLOOD.

Top Publications

  1. ncbi Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill
    R Zahorec
    Department of Anaesthesiology and Intensive Care Medicine, St Elizabeth Cancer Institute, Bratislava
    Bratisl Lek Listy 102:5-14. 2001
  2. pmc The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages
    Young Wha Koh
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic ro 43 gil, Seoul, Korea
    Oncologist 17:871-80. 2012
  3. ncbi Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer
    Khaled M Sarraf
    Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 137:425-8. 2009
  4. ncbi Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    B Autran
    Laboratoire d Immunologie Cellulaire, URA CNRS 625, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris, France
    Science 277:112-6. 1997
  5. pmc Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    J Pathol 222:350-66. 2010
  6. pmc Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    Frank A Sinicrope
    Miles and Shirley Fiterman Digestive Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:1270-9. 2009
  7. ncbi Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma
    Yoshio Ohno
    Department of Urology, Tokyo Medical University, Tokyo, Japan
    J Urol 184:873-8. 2010
  8. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
  9. ncbi Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome
    Umesh U Tamhane
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Cardiol 102:653-7. 2008
  10. ncbi Immunodeficiency in protein kinase cbeta-deficient mice
    M Leitges
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 273:788-91. 1996

Detail Information

Publications269 found, 100 shown here

  1. ncbi Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill
    R Zahorec
    Department of Anaesthesiology and Intensive Care Medicine, St Elizabeth Cancer Institute, Bratislava
    Bratisl Lek Listy 102:5-14. 2001
    ..We investigate whether serial examination of white blood cell counts may reflect and clarify the immune response to stressful events in critically ill patients...
  2. pmc The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin's lymphoma: correlation with tumor-associated macrophages
    Young Wha Koh
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic ro 43 gil, Seoul, Korea
    Oncologist 17:871-80. 2012
    ..A recent study suggested a prognostic role for the peripheral blood absolute lymphocyte count/absolute monocyte count (ALC/AMC) ratio at diagnosis in cHL...
  3. ncbi Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer
    Khaled M Sarraf
    Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 137:425-8. 2009
    ..We sought to determine factors associated with increasing neutrophil/lymphocyte ratios and the stage-adjusted prognostic effect in patients undergoing resection for non-small cell lung cancer...
  4. ncbi Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    B Autran
    Laboratoire d Immunologie Cellulaire, URA CNRS 625, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris, France
    Science 277:112-6. 1997
    ..Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients...
  5. pmc Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    J Pathol 222:350-66. 2010
    ..Our data offer a possible mechanism by which MSI confers an improved clinical outcome and support efforts to augment the host immune response in the tumour microenvironment as a strategy of targeted immunotherapy...
  6. pmc Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    Frank A Sinicrope
    Miles and Shirley Fiterman Digestive Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:1270-9. 2009
    ..We investigated whether the intratumoral densities of FoxP3(+) and effector CD3(+) lymphocytes are associated with prognosis of patients with colon cancer...
  7. ncbi Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma
    Yoshio Ohno
    Department of Urology, Tokyo Medical University, Tokyo, Japan
    J Urol 184:873-8. 2010
    ..We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio to predict recurrence in patients with nonmetastatic renal cell carcinoma...
  8. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Our results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments...
  9. ncbi Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome
    Umesh U Tamhane
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Cardiol 102:653-7. 2008
    ..Admission NLR is an independent predictor of in-hospital and 6-month mortality in patients with ACS. This relatively inexpensive marker of inflammation can aid in the risk stratification and prognosis of patients diagnosed with ACS...
  10. ncbi Immunodeficiency in protein kinase cbeta-deficient mice
    M Leitges
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 273:788-91. 1996
    ..Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction...
  11. ncbi Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue
    N Chaput
    Département de Biothérapie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Gut 58:520-9. 2009
    ..In this descriptive study, we analysed blood and tissue regulatory T cell populations in patients with CRC...
  12. pmc Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    Junzo Hamanishi
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 104:3360-5. 2007
    ..A significant inverse correlation was observed between PD-L1 expression and the intraepithelial CD8(+) T lymphocyte count, suggesting that PD-L1 on tumor cells directly suppresses antitumor CD8(+) T cells...
  13. ncbi Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment
    HanByoul Cho
    Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University College of Medicine, Gangnam Gu, Seoul, South Korea
    Cancer Immunol Immunother 58:15-23. 2009
    ....
  14. ncbi Absolute lymphocyte count at day 28 independently predicts event-free and overall survival in adults with newly diagnosed acute lymphoblastic leukemia
    Di Sun
    Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    Am J Hematol 87:957-60. 2012
    We investigated the prognostic impact of absolute lymphocyte count (ALC) following induction chemotherapy in newly diagnosed adult acute lymphoblastic leukemia (ALL)...
  15. pmc Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
    Crit Care 14:R192. 2010
    ..Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill ..
  16. ncbi Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study
    William T Shearer
    Baylor College of Medicine, Houston, Tex, USA
    J Allergy Clin Immunol 112:973-80. 2003
    ....
  17. ncbi Which white blood cell subtypes predict increased cardiovascular risk?
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 45:1638-43. 2005
    ..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
  18. pmc Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, USA
    Blood 117:5372-80. 2011
    ..Such a protective role of Tregs could have a profound impact on infection outcome...
  19. ncbi A potential role for interleukin-7 in T-cell homeostasis
    T J Fry
    Pediatric Oncology Branch, Biostatistics and Data Management Section, and HIV and AIDS Malignancy Branch of the National Cancer Institute, The National Institutes of Health, Bethesda, MD, USA
    Blood 97:2983-90. 2001
    ..In light of the known effects of IL-7 on T-cell regeneration, we postulate that increased availability of IL-7 could play a critical role in restoring T-cell homeostasis following T-cell depletion...
  20. ncbi Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland
    Leslie R Bisset
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Eur J Haematol 72:203-12. 2004
    ....
  21. ncbi Time course of endotoxin-induced airways' inflammation in healthy subjects
    Virginie Doyen
    Clinics of Immuno allergology, CHU Brugmann, Universite Libre de Bruxelles ULB, pl Van Gehuchten, 4, 1020, Brussels, Belgium
    Inflammation 35:33-8. 2012
    ..When repeated endotoxin inhalations are used as a model of inflammation, a wash-out period of at least 7 days should be applied between each exposure in each subject...
  22. ncbi Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients
    P R Fallen
    Anthony Nolan Research Institute, and Department of Haematology, Royal Free and University College Medical School, Royal Free Campus, Fleet Road, Hampstead, London NW3 2QG, UK
    Bone Marrow Transplant 32:1001-14. 2003
    ..This study suggests that future analysis of the factors affecting T cell reconstitution and studies aimed at reactivating the thymus through therapeutic intervention should be analysed in age-, GVHD- and TCD-matched patient groups...
  23. pmc The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, s Hertogenbosch, The Netherlands
    PLoS ONE 7:e46561. 2012
    The neutrophil-lymphocyte count ratio (NLCR) has been identified as a predictor of bacteremia in medical emergencies. The aim of this study was to investigate the value of the NLCR in patients with community-acquired pneumonia (CAP).
  24. ncbi Duodenal intraepithelial lymphocyte-count revisited
    B Veress
    Dept of Pathology, University Hospital MAS, Malmo, Sweden
    Scand J Gastroenterol 39:138-44. 2004
    ..The number of intraepithelial lymphocytes in the duodenum was determined 30 years ago, the suggested normal upper limit being 40 lymphocytes per 100 epithelial cells...
  25. ncbi Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans
    Daniela Fenoglio
    Centre of Excellence for Biological Sciences, University of Genoa, Genoa, Italy
    Blood 113:6611-8. 2009
    ....
  26. ncbi CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    Lawrence R Shiow
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 440:540-4. 2006
    ..These observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream of IFN-alpha/beta, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs...
  27. ncbi Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders
    Jeffrey T Bagdanoff
    Lexicon Pharmaceuticals, Princeton, New Jersey, USA
    J Med Chem 52:3941-53. 2009
    ..Reduction of S1PL activity by oral administration of these analogues recapitulated the phenotype of mice with genetically reduced S1PL expression...
  28. ncbi Peripheral regulatory T cells and serum transforming growth factor-β: relationship with clinical response to infliximab in Crohn's disease
    Antonio Di Sabatino
    First Department of Medicine, Centro per lo Studio e Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Inflamm Bowel Dis 16:1891-7. 2010
    ..Tumor necrosis factor (TNF)-α, which is centrally involved in Crohn's disease (CD) pathogenesis, also impairs Treg function. Here we investigated the influence of anti-TNF therapy on Treg frequency and function in CD...
  29. ncbi The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment
    Mehmet Aliustaoglu
    Department of Medical Oncology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    Med Oncol 27:1060-5. 2010
    ....
  30. ncbi Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:572-9. 2008
    ..However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations...
  31. ncbi Absolute lymphocyte count predicts overall survival in follicular lymphomas
    Mustaqeem Siddiqui
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 134:596-601. 2006
    The peripheral blood absolute lymphocyte count (ALC) recovery after autologous stem cell transplantation has been shown to be an independent prognostic factor for survival for different haematologic malignancies...
  32. ncbi Increased airway T regulatory cells in asthmatic subjects
    Lucy J C Smyth
    University of Manchester, NIHR Translational Research Facility, Manchester Academic Health Science Centre, University Hospital of South Manchester Foundation Trust, Manchester, England
    Chest 138:905-12. 2010
    ..We also investigated the regulatory function of CD4 cells by expression of cytotoxic T-lymphocyte antigen 4 (CTLA4), and the number of these cells that are intraepithelial lymphocytes expressing CD103...
  33. ncbi The search for a predictor of CD4 cell count continues: total lymphocyte count is not a substitute for CD4 cell count in the management of HIV-infected individuals in a resource-limited setting
    N O Akinola
    Department of Haematology and Immunology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
    Clin Infect Dis 39:579-81. 2004
    Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings...
  34. pmc IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques
    H Xu
    Tulane National Primate Research Center, Tulane University School of Medicine, 18703 Three Rivers Road, Covington, LA 70433, USA
    Mucosal Immunol 5:658-69. 2012
    ....
  35. pmc Absolute lymphocyte count on day 30 is a surrogate for robust hematopoietic recovery and strongly predicts outcome after T cell-depleted allogeneic stem cell transplantation
    Bipin N Savani
    Hematology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 13:1216-23. 2007
    Several studies have shown that a higher lymphocyte count 3-4 weeks after allogeneic stem cell transplantation (SCT) is associated with better transplant outcome. However, the factors determining early lymphocyte recovery are not defined...
  36. pmc IL-15 regulates homeostasis and terminal maturation of NKT cells
    Laura E Gordy
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 187:6335-45. 2011
    ..Taken together, our findings reveal a critical role for IL-15 in NKT cell survival, which is mediated by Bcl-x(L), and effector differentiation, which is consistent with a role of T-bet in regulating terminal maturation...
  37. ncbi Increased level of both CD4+FOXP3+ regulatory T cells and CD14+HLA-DR⁻/low myeloid-derived suppressor cells and decreased level of dendritic cells in patients with multiple myeloma
    M K Brimnes
    Center for Cancer Immune Therapy, Department of Haematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Scand J Immunol 72:540-7. 2010
    ..Taken together, our results illustrate that, both mDC, pDC, Treg cells and MDSC are affected in patients with MM underlining the fact that the immune system is dysregulated as a consequence of the disease...
  38. ncbi Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention
    Brendan K Duffy
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 97:993-6. 2006
    ..46, 95% confidence interval 1.4 to 4.4, p = 0.002). In conclusion, an elevated preprocedural N/L ratio in patients undergoing PCI is associated with an increased risk of long-term mortality...
  39. ncbi Androgen receptors in thymic epithelium modulate thymus size and thymocyte development
    N J Olsen
    Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 142:1278-83. 2001
    ..These data suggest that AR expressed by thymic epithelium are important modulators of thymocyte development...
  40. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  41. ncbi The relationship of depression and stressors to immunological assays: a meta-analytic review
    E P Zorrilla
    University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Brain Behav Immun 15:199-226. 2001
    ..The implications for these findings for disease susceptibility and the pathophysiology of these conditions is discussed...
  42. ncbi Management of nonresponse to rituximab in rheumatoid arthritis: predictors and outcome of re-treatment
    E M Vital
    University of Leeds, Chapel Allerton Hospital and Leeds Teaching Hospitals National Health Service Trust, Leeds, UK
    Arthritis Rheum 62:1273-9. 2010
    ..This study was undertaken to examine whether an additional cycle of rituximab would improve B cell depletion and clinical response in patients whose disease did not respond to the initial cycle...
  43. ncbi Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers
    Ammu K Radhakrishnan
    Department of Pathology, International Medical University, 126, Jalan 19 155B, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
    Br J Nutr 101:810-5. 2009
    ..As these observations were made in the absence of any immunogenic challenge, we feel it would be of benefit to study if there would be any differences observed when an immunogenic challenge such as vaccination were introduced...
  44. pmc Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival
    Geoffrey Y Ku
    Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 116:1767-75. 2010
    ..The authors report on advanced refractory melanoma patients treated in a compassionate use trial of ipilimumab at the Memorial Sloan-Kettering Cancer Center...
  45. ncbi Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies
    Guillermo De Angulo
    Division of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 112:407-15. 2008
    ..The prognostic significance of absolute lymphocyte counts (ALC) was evaluated in young patients with acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL)...
  46. pmc Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine
    Chuanwu Wang
    Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 184:5519-26. 2010
    ..The results indicate also that specific gut tropism of Th17 cells is determined by the combination of trafficking receptors regulated by the RA signal...
  47. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
    ..These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses...
  48. ncbi Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    Jeroen N Stoop
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    Hepatology 41:771-8. 2005
    ..T(reg) have an immunosuppressive effect on HBV-specific T helper cells. The presence of HBV-specific T(reg) could contribute to an inadequate immune response against the virus, leading to chronic infection...
  49. pmc Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice
    Joshua Kotner
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Infect Immun 75:861-9. 2007
    ..cruzi infection...
  50. pmc A positive correlation between atypical memory B cells and Plasmodium falciparum transmission intensity in cross-sectional studies in Peru and Mali
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e15983. 2011
    ..In this study we examined B cell subsets of Pf -infected adults in Peru and Mali to determine if Pf transmission intensity correlates with atypical memory B cell expansion...
  51. ncbi Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides
    Laurence Quemeneur
    Laboratoire d Immunopharmacologie, Institut National de la Santé et de la Recherche Médicale Unité 503, Centre d Etudes et de Recherche en Virologie et Immunologie, Institut Fédératif de Recherche 128 BioSciences Lyon Gerland, France
    J Immunol 170:4986-95. 2003
    ..These findings reveal a hitherto unknown role of purine and pyrimidine de novo synthesis in regulating cell cycle progression and maintaining survival of activated T lymphocytes...
  52. ncbi Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    Suzanne Mandala
    Department of Immunology and Rheumatology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA
    Science 296:346-9. 2002
    ..Inhibition of lymphocyte recirculation by activation of S1P receptors may result in therapeutically useful immunosuppression...
  53. ncbi The association between metal ions from hip resurfacing and reduced T-cell counts
    A J Hart
    Royal National Orthopaedic Hospital, Stanmore, UK
    J Bone Joint Surg Br 88:449-54. 2006
    ..A threshold level of blood cobalt and chromium ions was associated with reduced CD8(+) T-cell counts. We have no evidence that our patients suffered as a result of this reduced level of CD8(+) T-cells...
  54. ncbi IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates
    Terry J Fry
    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 101:2294-9. 2003
    ..These results also raise the possibility that IL-7 therapy could be used to temporarily modulate T-cell cycling in vivo in the context of immunotherapies such as vaccination...
  55. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
    ..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
  56. ncbi Usefulness of total lymphocyte count in monitoring highly active antiretroviral therapy in resource-limited settings
    Motasim Badri
    Somerset Hospital, University of Cape Town, South Africa
    AIDS 17:541-5. 2003
    To assess the usefulness of total lymphocyte count (TLC) for monitoring HIV-infected patients receiving highly active antiretroviral therapy. DESIGN Observational cohort study.
  57. pmc Bacteraemia prediction in emergency medical admissions: role of C reactive protein
    D H Wyllie
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 58:352-6. 2005
    ..To define the contribution made by C reactive protein (CRP) measurement to bacteraemia prediction in adults with medical emergencies in the UK...
  58. ncbi Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    Anders Wikby
    Department of Natural Science and Biomedicine, University College of Health Sciences, Jonkoping, Sweden
    Exp Gerontol 37:445-53. 2002
    ..As in the OCTO study, the NONA-Immune data indicated that the changes are associated significantly with seropositive responses to CMV...
  59. ncbi Intraepithelial lymphocytes in celiac disease
    Teea T Järvinen
    Department of Internal Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Am J Gastroenterol 98:1332-7. 2003
    ..The aim of this study was to investigate the value of immunohistochemical characterization of different intraepithelial lymphocytes (IELs) in the diagnostic workup of celiac disease (CD)...
  60. pmc Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion
    Zhi Jian Ye
    Department of Respiratory Diseases, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Clin Vaccine Immunol 18:1608-15. 2011
    ..This study shows that Th17/Treg imbalance exists in TPE and that pleural CD39(+) Tregs inhibit generation and differentiation of Th17 cells via a latency-associated peptide-dependent mechanism...
  61. ncbi FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Circulation 115:501-8. 2007
    ..The present study was undertaken to investigate whether modulation of S1P signaling would affect atherosclerosis in a murine model of disease...
  62. pmc Lymphocyte recovery is a major determinant of outcome after matched unrelated myeloablative transplantation for myelogenous malignancies
    Katarina Le Blanc
    Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Stockholm, Sweden
    Biol Blood Marrow Transplant 15:1108-15. 2009
    A higher absolute lymphocyte count 1 month (LC30) after allogeneic hematopoietic stem cell transplantation (HSCT) is associated with better outcome in patients transplanted from a matched sibling...
  63. pmc CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus
    Richard Stebbings
    Division of Immunology, NIBSC, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom
    J Virol 79:12264-72. 2005
    ....
  64. ncbi Absolute lymphocyte counts predicts response to chemotherapy and survival in diffuse large B-cell lymphoma
    D H Kim
    Leukemia 21:2227-30. 2007
  65. ncbi Absolute lymphocyte count predicts therapeutic efficacy and survival at the time of radioimmunotherapy in patients with relapsed follicular lymphomas
    L F Porrata
    Leukemia 21:2554-6. 2007
  66. ncbi Attenuation of invariant natural killer T-cell anergy induction through intradermal delivery of alpha-galactosylceramide
    Hetty J Bontkes
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands
    Clin Immunol 136:364-74. 2010
    ..In conclusion, glycolipids such as alphaGC may greatly improve the efficacy of skin immunization strategies, targeting cutaneous and lymph node DC...
  67. ncbi Preoperative lymphocyte count is an independent prognostic factor in node-negative non-small cell lung cancer
    Naohiro Kobayashi
    Department of Thoracic Surgery, University of Tsukuba, 1 1 1 Tennoudai Tsukuba 305 8575, Japan
    Lung Cancer 75:223-7. 2012
    ..5% for the high-neutrophil-count group (P=0.04). When the cut-off value of lymphocyte count was 1900 mm(-3) with a maximum log-rank statistical value, overall survival rates were 67...
  68. ncbi Lymphocyte count was significantly associated with hyper-LDL cholesterolemia independently of high-sensitivity C-reactive protein in apparently healthy Japanese
    Eiji Oda
    Medical Check up Center, Tachikawa Medical Center, Nagachou 2 2 16, Nagaoka, Niigata 940 0053, Japan
    Heart Vessels 27:377-83. 2012
    ..neutrophil, and lymphocyte counts were significant in men, and the OR of hyper-LDL cholesterolemia, for lymphocyte count, and the OR of hypo-HDL cholesterolemia for eosinophil count were significant in women...
  69. ncbi The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation
    Luca Piali
    Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123 Allschwil, Switzerland
    J Pharmacol Exp Ther 337:547-56. 2011
    ..Nonselective agonists for S1P receptors lead to blood lymphocyte count reduction...
  70. ncbi Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma
    Luis F Porrata
    Division of Hematology, Mayo Clinic, Rochester, MN, USA
    Leuk Lymphoma 53:2159-65. 2012
    The absolute monocyte/lymphocyte count prognostic score (AMC/ALC score) has not been directly compared with the cell of origin (COO) to predict overall survival (OS) and progression-free survival (PFS) in diffuse large B-cell lymphoma (..
  71. ncbi A novel mouse model for invariant NKT cell study
    Hiroshi Wakao
    Environmental Biology, School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:3888-95. 2007
    ..These mice will be useful for the study on the development of iNKT cells as well as on their functions in the immune system...
  72. ncbi Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial
    Muthiah Vaduganathan
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Heart Fail 5:750-8. 2012
    Low lymphocyte count has been shown to be an independent prognostic marker in heart failure (HF) in the outpatient setting...
  73. ncbi Prediction of survival using absolute lymphocyte count for newly diagnosed patients with multiple myeloma: a retrospective study
    Hilmi Ege
    Division of Hematology Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Br J Haematol 141:792-8. 2008
    Absolute lymphocyte count (ALC) recovery after autologous stem cell transplantation for multiple myeloma (MM) has been reported to be an independent prognostic factor for clinical outcome...
  74. ncbi Prognostic value of neutrophil to lymphocyte ratio in patients presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
    Jin Joo Park
    Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea Division of Cardiology, Department of Internal Medicine, College of Medicine, Seoul National University and Cardiovascular Center, Seoul National University Bundang Hospital, Gyeonggi Do, Korea
    Am J Cardiol 111:636-42. 2013
    ..The neutrophil/lymphocyte ratio (NLR) was calculated as the ratio of neutrophil count to lymphocyte count. The primary end point was all-cause death. Twenty-five patients (7...
  75. ncbi Absolute lymphocyte count is a novel prognostic indicator in extranodal natural killer/T-cell lymphoma, nasal type
    J J Huang
    State Key Laboratory of Oncology in Southern China
    Ann Oncol 22:149-55. 2011
    extranodal natural killer (NK)/T-cell lymphoma (ENKL) is a heterogeneous entity with poor survival, requiring risk stratification in affected patients. We proposed absolute lymphocyte count (ALC) as a new prognostic factor in ENKL.
  76. pmc Role of the neutrophil-lymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia
    Neul Bom Yoon
    Division of Respiratory Medicine, Department of Internal Medicine, Dong A University College of Medicine, Dong A University Medical Center, Busan, Korea
    Ann Lab Med 33:105-10. 2013
    ..The neutrophil-lymphocyte count ratio (NLR), a convenient marker of inflammation, has been demonstrated to be a useful biomarker for ..
  77. ncbi Duodenal intraepithelial lymphocytosis with normal villous architecture: common occurrence in H. pylori gastritis
    Lorenzo Memeo
    Department of Pathology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Mod Pathol 18:1134-44. 2005
    ....
  78. ncbi Total lymphocyte count as a possible surrogate of CD4 cell count to prioritize eligibility for antiretroviral therapy among HIV-infected individuals in resource-limited settings
    Richard Bedell
    Centre for Excellence in HIV AIDS, University of British Columbia, Vancouver, British Columbia, Canada
    Antivir Ther 8:379-84. 2003
    ..To characterize the value of total lymphocyte counts in predicting risk of death among patients initiating triple combination antiretroviral therapy...
  79. pmc A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis
    Johnson Ho
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 180:2573-80. 2008
    ..These inflammation-driven populations exert distinct roles during the development of chronic ileitis, and influence the balance of effector and regulatory functions in the chronically inflamed small intestine...
  80. ncbi Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome
    Paola Fogar
    Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Pancreas 32:22-8. 2006
    ..Our aim was to ascertain whether the immunophenotype pattern of blood lymphocytes in PC correlates with tumor stage, grade, or survival...
  81. ncbi Biological, histological, and clinical impact of preoperative IL-2 administration in radically operable gastric cancer patients
    Fabrizio Romano
    Department of Surgery, San Gerardo Hospital II University of Milan Bicocca, Italy
    J Surg Oncol 88:240-7. 2004
    ....
  82. ncbi Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice
    Longshan Liu
    Organ Transplant Center, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Microsurgery 27:300-4. 2007
    This study was performed to observe the long-term effect of FTY720 on lymphocyte count change and islet allograft survival. Diabetic C57BL/6 mice were given FTY720 (group 1, 0.5 mg/kg/day; group 2, 1...
  83. pmc Population-based hematologic and immunologic reference values for a healthy Ugandan population
    Eric S Lugada
    Center for International Health, University of Bergen, Bergen, Norway
    Clin Diagn Lab Immunol 11:29-34. 2004
    ..These differences could influence the decision to initiate antiretroviral therapy among children infected with HIV...
  84. ncbi Rapid modifications of peripheral T-cell subsets that express CD127 in macaques treated with recombinant IL-7
    Nathalie Dereuddre-Bosquet
    SPI Bio, CEA, Fontenay aux Roses, Cedex, France
    J Med Primatol 36:228-37. 2007
    ..Interleukin-7 (IL-7) is a key regulator of thymopoiesis and T-cell homeostasis, which increases blood T-cell number by enhancing thymic output of naive cells and peripheral proliferation...
  85. ncbi Prognosis and postoperative lymphocyte count in patients with hepatocellular carcinoma who received intraoperative allogenic blood transfusion: a retrospective study
    S Sugita
    Department of Surgery, National Hospital Organization Miyazaki Hospital, 19403 4 Kawaminami machi, Miyazaki 889 1301, Japan
    Eur J Surg Oncol 34:339-45. 2008
    ..To clarify the prognostic value of intraoperative allogenic blood transfusion, we conducted a comparative retrospective analysis of 224 patients with HCC who underwent hepatic resection...
  86. ncbi Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy
    Amita Gupta
    Division of Infectious Diseases Center for Clinical Global Health Education, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 46:338-42. 2007
    Some studies support the use of total lymphocyte count (TLC) as a surrogate marker for CD4 cell count to guide antiretroviral therapy (ART) initiation. However, most of these studies have focused on nonpregnant adults...
  87. ncbi Clinical impact of early absolute lymphocyte count after allogeneic stem cell transplantation
    Dong Hwan Kim
    Department of Haematology Oncology, Kyungpook National University Hospital, 50 Samduk 2 Ga, Jung Gu, Daegu 700 721, Korea
    Br J Haematol 125:217-24. 2004
    ..Therefore, the current study analysed the role of the absolute lymphocyte count (ALC) on day 21 after SCT in predicting transplant outcomes of 82 patients in terms of the risk of ..
  88. ncbi Use of total lymphocyte count for monitoring response to antiretroviral therapy
    Tanya Schreibman
    Yale University School of Medicine, AIDS Program, Yale New Haven Hospital, New Haven, Connecticut 06510, USA
    Clin Infect Dis 38:257-62. 2004
    ..The data regarding the clinical utility of the total lymphocyte count (TLC) as a potential surrogate marker of immune function in patients with HIV disease are examined...
  89. ncbi Enhancement of the efficacy of chemotherapy with oxaliplatin plus 5-fluorouracil by pretreatment with IL-2 subcutaneous immunotherapy in metastatic colorectal cancer patients with lymphocytopenia prior to therapy
    P Lissoni
    Division of Radiation Oncology, S Gerardo Hospital, Monza, Milan, Italy
    In Vivo 19:1077-80. 2005
    ..in metastatic colorectal cancer patients with pretreatment lymphocytopenia, which was defined as a lymphocyte count of less than 1500/mm3...
  90. pmc Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    U von Freeden-Jeffry
    Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Exp Med 181:1519-26. 1995
    ..These data show that proper T and B cell development is dependent on IL-7. The IL-7-deficient mice are the first example of single cytokine-deficient mice that exhibit severe lymphoid abnormalities...
  91. ncbi Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment
    Eiichi Ishikawa
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 50:638-44. 2010
    ..0001, R(2) = 0.569), and the most important predictor for CTC grade 4 lymphopenia was lymphocyte count before radiotherapy/TMZ less than 1200/microl by multivariate analysis (p < 0.0321, Exp = 13.2)...
  92. pmc The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes
    Darren A Cusanovich
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 21:2111-23. 2012
    ..To do so, we conducted a GWAS for lymphocyte count, a physiologic quantitative trait associated with asthma, in 462 Hutterites...
  93. ncbi Total lymphocyte count (TLC) is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries
    N Kumarasamy
    Y R G Centre for AIDS Research and Education, Chennai, India
    J Acquir Immune Defic Syndr 31:378-83. 2002
    ..OBJECTIVES To evaluate the correlation of total lymphocyte count (TLC), an inexpensive and widely available parameter, to CD4 count...
  94. ncbi Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection
    Pragati Nigam
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Emory University, Atlanta, GA 30329, USA
    J Immunol 186:745-53. 2011
    ..Depletion of Tc17 cells was not observed in colorectal mucosa of chronically infected SIV+ sooty mangabeys. In conclusion, our results suggest a role for Tc17 cells in regulating disease progression during pathogenic SIV infection...
  95. ncbi Total lymphocyte count and hemoglobin combined in an algorithm to initiate the use of highly active antiretroviral therapy in resource-limited settings
    Lisa A Spacek
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AIDS 17:1311-7. 2003
    ..To develop clinical algorithms that improve the sensitivity of surrogate markers to initiate the use of highly active antiretroviral therapy (HAART) in resource-limited settings...
  96. ncbi Decreased CD161+CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases
    A Mitsuo
    Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, Japan
    Rheumatology (Oxford) 45:1477-84. 2006
    ....
  97. ncbi Protein-bound polysaccharide increases survival in resected gastric cancer cases stratified with a preoperative granulocyte and lymphocyte count
    T Toge
    Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami Ku, Hiroshima City, Hiroshima 734 0037, Japan
    Oncol Rep 7:1157-61. 2000
    ..In 751 patients who underwent macroscopically curative resection preoperative granulocyte and lymphocyte count ratios (G/L) were measured. These patients were stratified with a preoperative cut-off of G/L:2...
  98. ncbi Size and dynamics of mucosal and peripheral IL-17A+ T-cell pools in pediatric age, and their disturbance in celiac disease
    R La Scaleia
    Department of Experimental Medicine, Sapienza University, Rome, Italy
    Mucosal Immunol 5:513-23. 2012
    ....
  99. pmc Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
    Marc K Hellerstein
    University of California, Berkeley, 119 Morgan Hall, Berkeley, California 94720 3104, USA
    J Clin Invest 112:956-66. 2003
    ..The greatest impact of advanced HIV-1 infection is to reduce the generation of long-lived, potential progenitor T cells...
  100. ncbi Short-term preoperative IL-2 immunotherapy in operable pancreatic cancer: a randomized study
    Franco Uggeri
    Department of Surgery, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy
    Hepatogastroenterology 56:861-5. 2009
    ..This study investigates the effectiveness of preoperative interleukin-2 administration to improve lymphocyte counts' postoperative recovery in pancreatic cancer...
  101. ncbi General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL
    Claudia Fazi
    Laboratory of B Cell Neoplasia, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Via Olgettina 60, Milan, Italy
    Blood 118:6618-25. 2011
    ....

Research Grants62

  1. Leptin as a Regulator of T Cell Metabolism and Function
    NANCIE MACIVER; Fiscal Year: 2013
    ..The hormone leptin, which is secreted by fat cells in proportion to fat mass and affects immune function, may be responsible for linking nutritional status with immune cell function. ..
  2. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
    Christina L Nance; Fiscal Year: 2011
    ..dose-blinded, randomized study of EGCG as monotherapy in participants who are HIV-1-infected with a CD4+ T lymphocyte count of at least 250 cells/mm3 and are ARV- nave or ARV-experienced...
  3. Pharmaconutrients as Therapies for Critical Illness: Zinc in Severe Sepsis
    Renee D Stapleton; Fiscal Year: 2013
    ..Zinc supplementation in healthy volunteers restores normal immune function including normalizing lymphocyte count, decreasing inflammatory cytokine production, restoring phagocytic activity of neutrophils, and reducing ..
  4. Non-CD4 Host defense against P. carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
    ..The well-known inverse relationship between CD4+ lymphocyte count and the risk of PC infection does not hold all of the answers to mechanisms of host defense against this ..
  5. Immune Response to pneumococcal vaccination in HIV infected adults
    M A Westerink; Fiscal Year: 2009
    ..the vaccine is less than optimal and correlates with the degree of immune suppression as measured by CD4+ T-lymphocyte count (1-10)...
  6. The Utility of Interferon-Gamma Release Assays in TB-HIV co-infected Children
    Anna M Mandalakas; Fiscal Year: 2011
    ..A focused set of standardized measures of age, nutrition and HIV-related immune status (CD4 T lymphocyte count) will be collected to fully assess their effect on the TST and IGRAs...
  7. T cells and P carinii Pneumonia
    Jay K Kolls; Fiscal Year: 2013
    ..Although there is a well- known relationship between CD4+ lymphocyte count and the risk of PC infection, the role of mononuclear phagocytes, CD8+ cells, gamma/delta T cells, and their ..
  8. Immune Response to pneumococcal vaccination in HIV infected adults
    M A JULIA WESTERINK; Fiscal Year: 2013
    ..the vaccine is less than optimal and correlates with the degree of immune suppression as measured by CD4+ T-lymphocyte count (1-10)...
  9. Muscle, Fat and NK Lymphocytes in Aging
    Charles T Lutz; Fiscal Year: 2013
    ..Our work will have a highly significant impact because it will open completely new areas of investigation and may suggest novel ways to treat both sarcopenia and declining immunity in aging. ..
  10. Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
    Carole Ober; Fiscal Year: 2013
    ..from 500 Hutterites that have been evaluated for asthma and phenotyped for 8 asthma-associated QTs: IgE, lymphocyte count, eosinophils, YKL-40, fractional exhaled nitric oxide (eNO), %predicted FEV1, FEV1/FVC ratio, and bronchial ..
  11. First Responders e-Training Curricula for Mass Screening After a Nuclear Event
    Michael Rea; Fiscal Year: 2011
    ..e., time to emesis, and serial lymphocyte count over a period of several days, and assumes that the medical system will have the capacity to admit every ..
  12. Tuberculosis Risk and Highly Active Antiretroviral Therapy Initiation
    APRIL PETTIT; Fiscal Year: 2013
    ..increase shortly following highly active antiretroviral therapy (HAART) initiation, which is guided by CD4+ T lymphocyte count (CD4+ count)...
  13. Treatment for depression and adherence in people living with HIV in Zimbabwe
    DICKSON CHIBANDA; Fiscal Year: 2013
    ..to estimate the effect of the integrated depression-adherence intervention on antiretroviral adherence, CD4 lymphocyte count, and depression...
  14. TICIPS: HIV/AIDS, Secondary Infections and Immune Modul*
    WILLIAM ROBERT FOLK; Fiscal Year: 2010
    ..Specific Aim 3: To assess the influence of Lessertia frutescens on CD4 T-lymphocyte count in HIVinfected adults...
  15. RISK SCORE FOR CORONARY ANEURYSMS IN KAWASAKI SYNDROME
    Jane Newburger; Fiscal Year: 1992
    ..of the disease: serum IgG, white blood count, differential- white-cell count, absolute band count, absolute lymphocyte count, hemoglobin, hematocrit, platelet count, alpha-1-antitrypsin, albumin, and C-reactive protein...
  16. Opioid-Mediated Fas Expression in Lymphocyte Apoptosis
    Yufang Shi; Fiscal Year: 2005
    ..The results should lead to an understanding of the effects of space flight environment on human immune system. ..
  17. Iscar for Supplemental Care in Stage IV Lung Cancer
    Steven Rosenzweig; Fiscal Year: 2003
    ..a.) will increase markers of immune function (as determined by total lymphocyte count, eosinophil count, and lymphocyte subset analysis), AND (l.b...
  18. HIV-related oral diseases among women in Harare
    John Greenspan; Fiscal Year: 2004
    ..oral mucosal disease incidence in relation to known immunologic marker of HIV disease progression (CD4 lymphocyte count); and 2) assess the sensitivity and specificity of detecting oral mucosal lesions by visual inspection of the ..
  19. Psychological stress, cortisol, and B lymphocyte decrements
    Bonnie McGregor; Fiscal Year: 2007
    ..The present study will begin to elucidate the mechanism by which psychological stress impairs immune response to vaccines. [unreadable] [unreadable] [unreadable]..
  20. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2001
    ..cellular immunity function will be accurate predictors for endodontic success or failure, and that the CD4 lymphocyte count alone is an inadequate base for making such decisions...
  21. T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    John Fahy; Fiscal Year: 2004
    ..abstract_text> ..
  22. PREVENTION OF PNEUMOCOCCAL DISEASE IN HIV INFECTION
    MARY MCELLISTREM; Fiscal Year: 2004
    ..concentrations will be analyzed by logistic regression to assess the effect of initial viral load and CD4 lymphocyte count. All patients who exhibit a greater that 3-fold transient rise in HIV-1 RNA levels 2 and 4 weeks ..
  23. Novel MRS Methods to Characterize MCMD
    Karl Goodkin; Fiscal Year: 2007
    ..disorder (MCMD)] and pathophysiological indices (plasma HIV-1 RNA load; CD4 cell count; cytotoxic T lymphocyte count)...
  24. PREVENTION OF HIV SHEDDING IN WOMEN--TRIAL OF VITAMIN A
    Julie Overbaugh; Fiscal Year: 2003
    ..In addition, venous blood will be obtained at the two time points for quantification of plasma HIV-1 RNA, CD4 lymphocyte count, and serum vitamin A levels...
  25. BIOLOGICAL STUDIES IN KAPOSI'S SARCOMA
    PHILIP BROWNING; Fiscal Year: 2000
    ..These values will be compared with CD4 lymphocyte count and extent of skin lesions...
  26. CELL PHENOTYPE AS A SURROGATE MARKER IN PEDIATRIC AIDS
    Susan Plaeger; Fiscal Year: 1990
    ..Studies of cell phenotype in the pediatric population are vital not only to understanding the immunopathogenesis of HIV infection children but to identifying surrogate markers essential to assessment of therapeutic interventions...
  27. Motivating HIV+ Women: Risk Reduction and ART Adherence
    MARCIA HOLSTAD; Fiscal Year: 2006
    ..Though effective in reducing the amount of circulating HIV virus and increasing the CD4 lymphocyte count, ART regimens are complex and have numerous side effects...
  28. NOVEL APPROACHES TO TARGET LATENT RESERVOIRS OF HIV-1
    Bharat Ramratnam; Fiscal Year: 2004
    ..Minimal estimates of the total-body HIV-1 pool size, assuming an average total lymphocyte count of 10xe212, suggest that after 2-3 years of treatment, approximately one million to ten million cells harbor ..
  29. EFFECTS OF CANCER CHEMOTHERAPY ON DIETARY HABITS
    Richard Mattes; Fiscal Year: 1991
    ..status will be monitored via assessments of weight, serum albumin and transferrin as well as total lymphocyte count and correlated with the incidence of aversions and treatment outcome...
  30. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..women with (cases) and without (control) elevated breastmilk sodium were matched by plasma HIV load and CD4+ lymphocyte count. Cases has a median breastmilk HIV load of 1765 copies/mL compared with undetectable load in controls (p less ..
  31. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  32. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  33. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  34. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  35. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  36. Fluoroquinolone Resistance in M. Tuberculosis
    Timothy R Sterling; Fiscal Year: 2010
    ..tuberculosis would clarify whether fluoroquinolones are indeed a viable option for the first-line treatment of tuberculosis, and how best to preserve their usefulness against tuberculosis. ..
  37. CD8+TCell Antiretroviral Mechanisms in Lymphoid Tissue
    Elizabeth Connick; Fiscal Year: 2003
    ..These studies could provide important insight into the immunopathogenesis of HIV-1 infection and suggest alternative targets for immune therapies. ..
  38. Oxidant Stress and Antioxidants during HIV Therapy
    Todd Hulgan; Fiscal Year: 2007
    ..The candidate's long-term goal is to develop into an independent clinical investigator in this field of study. ..
  39. T Cell Immunity & Liver Fibrosis in HCV/HIV Coinfection
    Chihiro Morishima; Fiscal Year: 2003
    ..Finally, we will test the hypotheses that HCV/HIV coinfected subjects treated with HAART will demonstrate improved HCV-specific CD4+ T cell function that is not fibrogenic, and is sequestered to the liver. ..
  40. IMMUNOPATHOGENESIS OF ACUTE HIV-1 INFECTION
    Elizabeth Connick; Fiscal Year: 2007
    ..abstract_text> ..
  41. Mitochondrial Genomics and Peripheral Neuropathy during HIV Therapy
    Todd Hulgan; Fiscal Year: 2008
    ..Results from this study will also advance the field of "mitochondrial medicine", having broad application across other scientific disciplines and for other human diseases. [unreadable] [unreadable] [unreadable]..
  42. Nonablative AlloSCT in Refractory Autoimmune Disease
    Mitchell Cairo; Fiscal Year: 2003
    ....
  43. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2003
    ....
  44. RBC MASS, ANS INTEGRITY & SYNCOPE SUSCEPTIBILITY IN CFS
    Barry Hurwitz; Fiscal Year: 2003
    ....
  45. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  46. FACSVantage SE
    Beth Jamieson; Fiscal Year: 2002
    ..The FCCF staff will continue to develop and adapt novel technologies for use with the new instrument to support UCLA investigators in their efforts to remain on the cutting edge of science. ..
  47. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 2001
    ..Finally, in Aim 4 we will assess the role of monocyte and P450 expression by Western blot and RT-PCR methods in subsets of HPBMC and human cell lines (above). ..
  48. First Int'l Symposium on Childhood and Adolescent NHL
    Mitchell Cairo; Fiscal Year: 2003
    ..abstract_text> ..
  49. Cranial Stimulation for Chemo Symptoms in Breast Cancer
    Debra Lyon; Fiscal Year: 2004
    ..abstract_text> ..
  50. Autonomic nervous system control of HIV-1 replication
    Steve Cole; Fiscal Year: 2005
    ..Such interventions would enhance the efficacy of current antiretroviral treatment regimens by opposing physiologic processes that support ongoing pathogenesis. ..
  51. CONFERENCE ON HIV PATHOGENESIS
    Michael Lederman; Fiscal Year: 2005
    ....
  52. HIV/HCV Co-infection: HAART and CVD Pathophysiology
    Barry Hurwitz; Fiscal Year: 2006
    ..abstract_text> ..
  53. Immune Mechanisms and HIV Disease Pathogenesis
    Michael Lederman; Fiscal Year: 2004
    ..The proposal's specific request is for support to increase participation in the Conference by female and/or minority researchers and students. ..
  54. Memory CD8 T cell subset cooperation via chemokines in protective immunity to inf
    E Wherry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Aberrant T Cell Function and Immunopathogenesis of CMV Immune Recovery Uveitis
    Mark Jacobson; Fiscal Year: 2008
    ..Thus, understanding the disease mechanism of CMV IRU could facilitate development of effective therapy for CMV IRU or diagnostic or treatment strategies to prevent CMV IRU. [unreadable] [unreadable] [unreadable]..
  56. Directly Observed Therapy for Community-Released HIV-positive Prisoners
    Frederick Altice; Fiscal Year: 2008
    ..It is therefore likely that the stated aim will be successfully accomplished, despite the challenges of working with prisoners and drug-using populations. [unreadable] [unreadable]..
  57. HIV-1 Transgenic Rat Develops Abnormal T Cells Subsets
    William Reid; Fiscal Year: 2007
    ..Our goals are to understand how expression of HIV gene products causes defects in the development or maintenance of T cell effector function in Tg rats and to identify the relevant viral gene. ..
  58. Pediatric ACTG Coordinating and Operations Center
    Stephen Spector; Fiscal Year: 2005
    ..abstract_text> ..
  59. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2004
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
  60. Phase I Study of ALT-801 in Metastatic Melanoma/Kidney Cancer Patients
    Mayer Fishman; Fiscal Year: 2009
    ....