enzyme tests

Summary

Top Publications

  1. ncbi Prognostic value of troponin T, troponin I, and CK-MBmass in patients with chronic renal failure
    Dirk Peetz
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Mainz, Johannes Gutenberg University, Germany
    Med Klin (Munich) 98:188-92. 2003
  2. ncbi Screening of periodontitis with salivary enzyme tests
    Yoshiaki Nomura
    Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine, Yokohama, Kanagawa, Japan
    J Oral Sci 48:177-83. 2006
  3. ncbi [The importance of AST / ALT rate in nonalcoholic steatohepatitis diagnosis]
    Júnior Idilio Zamin
    Faculdade Federal de Ciências Médicas de Porto Alegre FFFCMPA e Irmandade Santa Casa de Misericórdia de Porto Alegre
    Arq Gastroenterol 39:22-6. 2002
  4. ncbi The role of elevated liver transaminase levels in children with blunt abdominal trauma
    Dolunay Karaduman
    Department of Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Injury 34:249-52. 2003
  5. ncbi Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity
    Rathanam Boopathy
    Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
    Clin Chim Acta 380:151-6. 2007
  6. pmc A case-control study of SARS versus community acquired pneumonia
    F W T Cheng
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong
    Arch Dis Child 90:747-9. 2005
  7. ncbi In vitro measurement of enzymatic markers as a tool to detect mouse cardiomyocytes injury
    Elen Mello de Souza
    Laboratorio de Biologia Celular, Departamento de Ultra estrutura e Biologia Celular, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, RJ, Brazil
    Mem Inst Oswaldo Cruz 99:697-701. 2004
  8. ncbi Cardiac troponin T and myocardial injury during routine cardiac catheterisation in children
    Dursun Alehan
    Pediatric Cardiology Unit, Hacettepe University, Ihsan Dogramaci Children s Hospital, Sihhiye 06100, Ankara, Turkey
    Int J Cardiol 87:223-30. 2003
  9. ncbi Comparison of 2-dimensional echocardiography and myocardial perfusion imaging for diagnosing myocardial infarction in emergency department patients
    Michael C Kontos
    Department of Internal Medicine Cardiology, Medical College of Virginia, Campus of Virginia Commonwealth University, Richmond, VA, USA
    Am Heart J 143:659-67. 2002
  10. ncbi Metrological traceability of values for catalytic concentration of enzymes assigned to a calibration material
    Francesca Canalias
    Departament de Bioquimica i Biologia Molecular, Unitat de Bioquímica de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Clin Chem Lab Med 44:333-9. 2006

Detail Information

Publications151 found, 100 shown here

  1. ncbi Prognostic value of troponin T, troponin I, and CK-MBmass in patients with chronic renal failure
    Dirk Peetz
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Mainz, Johannes Gutenberg University, Germany
    Med Klin (Munich) 98:188-92. 2003
    ..The aim of this study was to investigate the prognostic power of a new, sensitive TnI assay in comparison with TnT and other cardiac markers...
  2. ncbi Screening of periodontitis with salivary enzyme tests
    Yoshiaki Nomura
    Department of Preventive Dentistry and Public Health, Tsurumi University School of Dental Medicine, Yokohama, Kanagawa, Japan
    J Oral Sci 48:177-83. 2006
    ..markers for the screening of periodontal disease and examine the agreement between the results of saliva enzyme tests and those of probing depth...
  3. ncbi [The importance of AST / ALT rate in nonalcoholic steatohepatitis diagnosis]
    Júnior Idilio Zamin
    Faculdade Federal de Ciências Médicas de Porto Alegre FFFCMPA e Irmandade Santa Casa de Misericórdia de Porto Alegre
    Arq Gastroenterol 39:22-6. 2002
    ..There is a histologic similarity between nonalcoholic steatohepatitis and alcoholic liver disease and in some cases differential diagnosis may be difficult, since some patients do not report abusive alcohol consumption...
  4. ncbi The role of elevated liver transaminase levels in children with blunt abdominal trauma
    Dolunay Karaduman
    Department of Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Injury 34:249-52. 2003
    ..A sudden rise up to 110.5 U/l in SGOT and 63.5 U/l in SGPT indicate an intra-abdominal injury and severe hepatic injury should be suspected with higher levels of SGOT and SGPT...
  5. ncbi Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity
    Rathanam Boopathy
    Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
    Clin Chim Acta 380:151-6. 2007
    ..AST and gamma GT values were taken into account in this study as known markers for liver disorders...
  6. pmc A case-control study of SARS versus community acquired pneumonia
    F W T Cheng
    Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong
    Arch Dis Child 90:747-9. 2005
    ..Raised serum lactate dehydrogenase concentration in the presence of low neutrophil count and serum creatine phosphokinase level at presentation also indicated an increased likelihood of SARS-coronavirus infection in young children...
  7. ncbi In vitro measurement of enzymatic markers as a tool to detect mouse cardiomyocytes injury
    Elen Mello de Souza
    Laboratorio de Biologia Celular, Departamento de Ultra estrutura e Biologia Celular, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, RJ, Brazil
    Mem Inst Oswaldo Cruz 99:697-701. 2004
    ....
  8. ncbi Cardiac troponin T and myocardial injury during routine cardiac catheterisation in children
    Dursun Alehan
    Pediatric Cardiology Unit, Hacettepe University, Ihsan Dogramaci Children s Hospital, Sihhiye 06100, Ankara, Turkey
    Int J Cardiol 87:223-30. 2003
    ..This study aims to investigate whether intracardiac catheterization produces myocardial damage on pediatric heart...
  9. ncbi Comparison of 2-dimensional echocardiography and myocardial perfusion imaging for diagnosing myocardial infarction in emergency department patients
    Michael C Kontos
    Department of Internal Medicine Cardiology, Medical College of Virginia, Campus of Virginia Commonwealth University, Richmond, VA, USA
    Am Heart J 143:659-67. 2002
    ..However, the inclusion of small numbers of patients in prior studies limits the accurate assessment of sensitivity of the 2 techniques...
  10. ncbi Metrological traceability of values for catalytic concentration of enzymes assigned to a calibration material
    Francesca Canalias
    Departament de Bioquimica i Biologia Molecular, Unitat de Bioquímica de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Clin Chem Lab Med 44:333-9. 2006
    ..The metrological traceability of values for the catalytic concentration of several enzymes assigned to a calibration material has been assured by following the recently published International Standard ISO 18153...
  11. ncbi IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C
    Gerhard Schumann
    Klinische Chemie, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Clin Chem Lab Med 44:1146-55. 2006
    ..The procedure described here is deduced from the previously described 30 degrees C IFCC reference method. Differences are tabulated and commented on...
  12. ncbi Correlation of serum aminotransferases with HCV RNA levels and histological findings in patients with chronic hepatitis C: the role of serum aspartate transaminase in the evaluation of disease progression
    Barbara Zechini
    Department of Infectious Diseases, Sant Andrea Hospital, University of Rome La Sapienza, Italy
    Eur J Gastroenterol Hepatol 16:891-6. 2004
    ..To investigate whether HCV RNA levels can be considered to be predictors of hepatocellular injury in patients with chronic hepatitis C, and whether aminotransferase levels are markers of liver damage...
  13. ncbi De Ritis ratio as diagnostic marker of alcoholic liver disease
    Shankhar Majhi
    Department of Clinical Laboratory Services Biochemistry Unit, B P Koirala Institute of Health Sciences, Ghopa Dharan Nepal
    Nepal Med Coll J 8:40-2. 2006
    ..A mild to moderate disproportionate elevation of AST than ALT activity making De Ritis Ratio > 2:1, supported by reversal of Albumin/globulin ratio facilitates the diagnosis...
  14. ncbi Evaluation of adenosine deaminase seric activity in the diagnosis of bovine tuberculosis
    Marcio Roberto Silva
    Departamento de Medicina Veterinaria Preventiva, Núcleo de Pesquisa em Saúde Animal, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30123 970, Brasil
    Mem Inst Oswaldo Cruz 101:391-5. 2006
    ..086 and kappa = -0.082, respectively). In conclusion, the determination of ADA seric activity was not a good auxiliary test for bovine TB, because it was not able to distinguish between TB-positive and TB-negative animals...
  15. ncbi [HBV DNA levels, aminotransferase and histological activity in young male patients with HBeAg positive chronic hepatitis B]
    Seung Chul Cho
    Department of Internal Medicine, College of Medicine, Hanyang University Institute of Digestive Diseases, Seoul, Korea
    Taehan Kan Hakhoe Chi 8:44-51. 2002
    ..We assessed ALT, AST, and HBV-branched DNA to find which is the best for predicting hepatitis activity and fibrosis...
  16. ncbi Identification of children with intra-abdominal injuries after blunt trauma
    James F Holmes
    Division of Emergency Medicine, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA 95817 2282, USA
    Ann Emerg Med 39:500-9. 2002
    ..We sought to determine the utility of laboratory testing after adjusting for physical examination findings in the identification of children with intra-abdominal injuries after blunt trauma...
  17. ncbi Fecal elastase-1: utility in pancreatic function in cystic fibrosis
    Ameet Daftary
    Department of Pulmonary Medicine and Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Cyst Fibros 5:71-6. 2006
    ..This review summarizes the data from studies reflecting the validity, limitation and advantages of fecal elastase-1 in assessing pancreatic function in cystic fibrosis patients...
  18. ncbi Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?
    Serena Mazzotta
    Department of Hematology and Transplants, University of Siena, Siena, Italy
    Hematology 11:239-44. 2006
    ..These data suggest that LDH isoenzyme patterns may be a useful marker of CMDs, but this enzymatic pattern could be expression of a metabolic adaptation...
  19. ncbi Serum cystatin C and urinary enzymes as screening markers of renal dysfunction in diabetic patients
    Sema Uslu
    Department of Biochemistry, Medical Faculty, Osmangazi University, Eskisehir Turkey
    J Nephrol 18:559-67. 2005
    ..Therefore, this study was designed to determine whether the serum cystatin C (Cys C) and activities of some tubular enzymes could be used as screening markers for renal dysfunction in diabetic patients...
  20. ncbi Lactate dehydrodgenase levels predict pulmonary morbidity after lung resection for non-small cell lung cancer
    Akif Turna
    Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul, Turkey
    Eur J Cardiothorac Surg 26:483-7. 2004
    ..The purpose of this study was to identify preoperative factors associated with the development of pulmonary complications after lung resections to help predict which patients are at increased risk for morbidity...
  21. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
  22. ncbi The diagnostic value of adenosine deaminase activity in sputum in pulmonary tuberculosis
    A Dilmaç
    Department of Chest Diseases, Ataturk Chest Diseases and Surgery Center, Ankara, Turkey
    Respir Med 96:632-4. 2002
    ..It's aim to determine and compare sputum adenosine deaminase (ADA) activity in pulmonary tuberculosis (tb), lung cancer and chronic obstructive pulmonary disease (COPD) patients in order to assess its diagnostic value...
  23. ncbi Diagnostic value of alpha-glutathione S-transferase as a sensitive marker of increased risk for hepatocellular damage in hepatitis C virus (HCV) infection: relation to HCV viraemia
    Ghada Fahmy Helaly
    Department of Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt
    J Egypt Public Health Assoc 78:209-23. 2003
    ....
  24. ncbi Milk thistle for the treatment of liver disease: a systematic review and meta-analysis
    Bradly P Jacobs
    Department of Medicine, University of California, San Francisco 94143, USA
    Am J Med 113:506-15. 2002
    ..We performed a systematic review of the literature to determine the efficacy and safety of this herb for the treatment of liver disease...
  25. ncbi Evaluation of a new Plasmodium lactate dehydrogenase assay (OptiMAL-IT) for the detection of malaria
    S Pattanasin
    Shoklo Malaria Research Unit, PO Box 46, Mae Sod 63110, Thailand
    Trans R Soc Trop Med Hyg 97:672-4. 2003
    ..For species other than P. falciparum, the sensitivity was 65% and specificity was 99%. The performance of the new test decreased markedly at low levels of parasitaemia...
  26. ncbi [Elevation of serum lactate dehydrogenase. Diagnostic, prognostic and evolutive values]
    S Berthier
    Service de Médecine Interne et d Immunologie Clinique, Hopital Le Bocage, Bd du Mal de Lattre de Tassigny, F21000 Dijon
    Presse Med 31:107-12. 2002
    ..However, its place in the diagnosis process is not clear. We have collected serum LDH levels superior to 2-fold the normal rate and we tried to determine their diagnostics interest and, predictive and progressive values...
  27. pmc Gamma-glutamyltransferase and risk of stroke: the EUROSTROKE project
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i25-9. 2002
    ....
  28. pmc Serum amylase and acute pancreatitis
    John Butler
    Department of Emergency Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Emerg Med J 20:550-1. 2003
    ..The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated...
  29. ncbi Updated definitions of healthy ranges for serum alanine aminotransferase levels
    Daniele Prati
    Centro Trasfusionale e di Immunologia dei Trapianti, Laboratorio di Epidemiologia, Divisione di Ematologia, Istituto di Statistica Medica e Biometria, Cattedra di Gastroenterologia, Milan, Italy
    Ann Intern Med 137:1-10. 2002
    ..Current standards for "normal" ALT level were defined by using populations that included persons with subclinical liver disease...
  30. ncbi gamma-Glutamyltransferase as a predictor of chronic kidney disease in nonhypertensive and nondiabetic Korean men
    Seungho Ryu
    Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
    Clin Chem 53:71-7. 2007
    ..We performed a prospective study to examine the association between GGT and the risk for the development of CKD...
  31. ncbi The chlorinated AHR ligand 3,3',4,4',5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus)
    Xabier Arzuaga
    Graduate Center for Toxicology, 306 Health Sciences Research Building, Lexington, KY 40536 0305, USA
    Aquat Toxicol 76:13-23. 2006
    ....
  32. ncbi Is the change of late potential over time related to enzyme levels? Ischemic burden in acute myocardial infarction
    Namik Kemal Eryol
    Department of Cardiology, Medical Faculty, Erciyes University, Kayseri, Turkey
    Ann Noninvasive Electrocardiol 7:242-6. 2002
    ..The ventricular late potential (VLP) detected using the technique of signal average electrocardiography (SAECG) interacts with several factors, primarily time...
  33. ncbi [Hepatotoxicity of antitubercular drugs. Apropos of 28 cases]
    Abdelmajid Sakhri
    Service de Pneumo allergologie Hôpital Militaire Principal d Instuction de Tunis
    Tunis Med 81:488-94. 2003
    ..So that we have to take an interest at time and specialty to follow recommandation which are more and more codified...
  34. ncbi Activated partial thromboplastin time abnormality in patients with cholangiocarcinoma
    Viroj Wiwanitkit
    Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Appl Thromb Hemost 10:69-71. 2004
    ..However, because the total number of cases in this study is rather small, a larger study to answer this question is necessary. In addition, the more systematic evaluations are required to answer the raised hypothesis...
  35. ncbi Now that fecal elastase is available in the United States, should clinicians start using it?
    Paul G Lankisch
    Clinic of Internal Medicine, Municipal Clinic of Lueneburg, Boegelstrasse 1, D 21339 Lueneburg, Germany
    Curr Gastroenterol Rep 6:126-31. 2004
    ..The test cannot be used in non-formed stool (ie, diarrhea) unless the stool is lyophilized. All in all, this new test does not seem to be the gold standard for pancreatic function that we have been waiting for...
  36. ncbi [Chronic hepatitis C with normal level of alanine-aminotransferase]
    Giuliano Rossi
    Primario Medico f r, Ospedale San Filippo Neri, Roma
    Recenti Prog Med 95:509-11. 2004
    ..The role of liver biopsy and the effectiveness of the antiviral therapy with peg-interferon and ribavirin in these patients are briefly discussed...
  37. ncbi A clinical decision rule for identifying children with thoracic injuries after blunt torso trauma
    James F Holmes
    Division of Emergency Medicine, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA 95817 2282, USA
    Ann Emerg Med 39:492-9. 2002
    ..We sought to determine the prevalence of thoracic injuries in children sustaining blunt torso trauma and to develop a clinical prediction rule to identify children with these injuries...
  38. pmc Evaluation of polymerase chain reaction and adenosine deaminase assay for the diagnosis of tuberculous effusions in children
    O P Mishra
    Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Arch Dis Child 91:985-9. 2006
    ..To evaluate and compare the utility of polymerase chain reaction (PCR) for the diagnosis of tuberculous effusions in children...
  39. ncbi [Adenosine deaminase 2 in the diagnosis of tuberculous pleuritis]
    Naohiko Inase
    Department of Internal Medicine, Yokosuka Kyosai Hospital, 1 16, Yonegahama dori, Yokosuka shi, Kanagawa 238 8558, Japan
    Kekkaku 80:731-4. 2005
    ..We examined the usefulness of adenosine deaminase 2 (ADA2) in the diagnosis of tuberculous pleuritis...
  40. ncbi [Isolated increase of the serum aspartate aminotransferase level in a young asymptomatic patient: macro-AST]
    F Vandenbussche
    Dienst Maag, Darm en Leverziekten, Algemeen Ziekenhuis Sint Jan, Ruddershove 10, 8000 Brugge, Belgie
    Ned Tijdschr Geneeskd 149:2807-9. 2005
    ..The presence of such complexes was confirmed by means ofa polyethylene glycol precipitation assay. This is a simple test for the detection of macro-AST, which saves the asymptomatic patient further invasive diagnostic procedures...
  41. ncbi Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis: a meta-analysis
    Arnoldo Riquelme
    Faculty of Medicine, Department of Gastroenterology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Clin Gastroenterol 40:705-10. 2006
    ..The goals of this study are: to determine the usefulness of ADA levels in ascitic fluid as a diagnostic test for peritoneal tuberculosis (PTB) and define the best cut-off point...
  42. ncbi Trypsin activity in stool and duodenal aspirate of neonates for differential diagnosis of intestinal obstruction
    I V Meisheri
    Department of Pediatric Surgery, B J Wadla Hospital for Children and Research Centre Parel, Mumbai 400 004, India
    Pediatr Surg Int 18:104-6. 2002
    ....
  43. ncbi [Lymphoproliferative lesions of the ocular adnexa. Differential diagnostic guidelines]
    S E Coupland
    Institut fur Pathologie, Charite Universitatsmedizin, Campus Benjamin Franklin, Berlin
    Ophthalmologe 101:197-215; quiz 216-7. 2004
    ..H.O. lymphoma classification and the tumour cell growth rate. The clinical symptoms and histopathological findings of the differential diagnosis of lymphoproliferative lesions of the ocular adnexa are discussed...
  44. ncbi Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores
    Georges Ferard
    Faculte de Pharmacie, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Clin Chem Lab Med 44:400-6. 2006
    ..8% and 3.3% for ALT and GGT, respectively. For each enzyme, it also permitted the retention of a common reference interval for a set of calibrated methods and the improvement of inter-laboratory coherency of Fibrotest and Actitest scores...
  45. ncbi [The role of glucocorticoid-dependent mechanisms in the progression of experimentally induced acute pancreatitis]
    Attila Paszt
    Szegedi Tudomanyegyetem, Altalános Orvostudományi Kar Sebészeti Klinika, 6720 Szeged, Pécsi u 4
    Magy Seb 56:185-92. 2003
    ....
  46. ncbi [Hemolysis, elevated liver enzymes, and low platelet count syndrome]
    Dalia Adukauskiene
    Clinic of Intensive Care, Kaunas University of Medicine, Lithuania
    Medicina (Kaunas) 42:695-702. 2006
    ..That is why now many authors agree that treatment approach should be based on the estimated gestational age and the condition of the mother and fetus...
  47. doi International criteria for the diagnosis of ocular sarcoidosis: results of the first International Workshop On Ocular Sarcoidosis (IWOS)
    Carl P Herbort
    Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care, Lausanne, Switzerland
    Ocul Immunol Inflamm 17:160-9. 2009
    ..To report criteria for the diagnosis of intraocular sarcoidosis, taking into account suggestive clinical signs and appropriate laboratory investigations and biopsy results...
  48. doi Molecular epidemiology of rotaviruses in Bulgaria: annual shift of the predominant genotype
    Z Mladenova
    Department of Virology, National Reference Laboratory of Enteroviruses, National Center of Infectious and Parasitic Diseases, 44A Stoletov Blvd, Sofia 1233, Bulgaria
    Eur J Clin Microbiol Infect Dis 29:555-62. 2010
    ..A total of 3,130 stools collected between 2005 and 2008 were tested by immune enzyme tests. G-P genotype identification of rotavirus strains were performed by reverse transcriptase polymerase chain ..
  49. ncbi Hepatic gene expression response to acute indomethacin exposure
    William A LaFramboise
    Department of Pathology, University of Pittsburgh School of Medicine, Shadyside Hospital, Pittsburgh, Pennsylvania 15232, USA
    Mol Diagn Ther 10:187-96. 2006
    ....
  50. ncbi [Demand for neuropediatric care in a regional general hospital. V. Complementary tests]
    J Lopez-Pison
    Sección de Neuropediatría, Hospital Miguel Servet, Zaragoza, Espana
    Rev Neurol 26:208-14. 1998
    ..to diagnosis on few occasions, most frequently the CSF (basically in meningitis and encephalitis) and muscle enzyme tests were also useful...
  51. pmc Low-risk patients with chest pain in the emergency department: negative 64-MDCT coronary angiography may reduce length of stay and hospital charges
    Janet M May
    Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific St, RR210, Box 357115, Seattle, WA 98195, USA
    AJR Am J Roentgenol 193:150-4. 2009
    ..We hypothesized that negative 64-MDCT coronary angiography early in the workup of such patients may enable a shorter length of stay and reduce charges...
  52. pmc Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide
    J R Curtis
    Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 510 20 Street South, FOT 840, Birmingham, AL 35294, USA
    Ann Rheum Dis 69:43-7. 2010
    ....
  53. ncbi Comparative histochemistry of a flatfish fin muscle and of other vertebrate muscles used for ultrastructural studies
    N Chayen
    Biophysics Section, Blackett Laboratory, Imperial College, London, U K
    J Muscle Res Cell Motil 8:358-71. 1987
    ..types is rather difficult to collate, we summarize here the fibre compositions of several muscles; comparable enzyme tests have been carried out on cryostat sections of rabbit psoas muscle, frog sartorius and semitendinosus muscles ..
  54. ncbi Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT
    Daniel A Vallera
    Section on Molecular Cancer Therapeutics, Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis 55455, USA
    J Natl Cancer Inst 94:597-606. 2002
    ....
  55. ncbi Spongiibacter marinus gen. nov., sp. nov., a halophilic marine bacterium isolated from the boreal sponge Haliclona sp. 1
    Ingeborg Graeber
    Berlin University of Technology, Environmental Microbiology Group, Franklinstrasse 29, Sekr FR 1 2, D 10587 Berlin, Germany
    Int J Syst Evol Microbiol 58:585-90. 2008
    ..Substrate utilization tests were positive for arabinose, Tween 40 and Tween 80. Enzyme tests were positive for alkaline phosphatase, esterase lipase (C8), leucine arylamidase, acid phosphatase, naphthol-..
  56. ncbi Irinotecan chemotherapy during valproic acid treatment: pharmacokinetic interaction and hepatotoxicity
    Floris A de Jong
    Department of Medical Oncology, Erasmus MC University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Cancer Biol Ther 6:1368-74. 2007
    ..Here, we report on the pharmacokinetic and pharmacodynamic effects of this combination in a cancer patient...
  57. ncbi Serum protein alterations in dogs naturally infected with Toxoplasma gondii
    Gul Fatma Yarim
    Department of Biochemistry, Faculty of Veterinary Medicine, University of Ondokuz Mayis, 55139, Kurupelit, Samsun, Turkey
    Parasitol Res 101:1197-202. 2007
    ..correlations were determined between the percentages of the albumin and gamma globulin fractions and liver enzyme tests including aspartate aminotransferase and alanine aminotransferase in infected dogs; however, no correlation was ..
  58. ncbi Ursodeoxycholic acid treatment in isolated chronic graft-vs.-host disease of the liver
    Mutlu Arat
    Department of Hematology, Ankara University School of Medicine, Ankara, Turkey
    Clin Transplant 19:798-803. 2005
    ....
  59. ncbi Spongiispira norvegica gen. nov., sp. nov., a marine bacterium isolated from the boreal sponge Isops phlegraei
    Ines Kaesler
    Berlin University of Technology, Environmental Microbiology Group, Franklinstrasse 29, Sekr FR 1 2, Berlin, Germany
    Int J Syst Evol Microbiol 58:1815-20. 2008
    ..Substrate utilization tests were only positive for arabinose. Enzyme tests were positive for esterase lipase C8, lipase C14, leucine arylamidase and naphthol-AS-BI-phosphohydrolase...
  60. doi Aluminum-mediated metabolic changes in rat serum and urine: a proton nuclear magnetic resonance study
    Sandeep Tripathi
    Department of Biochemistry, Chattrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India
    J Biochem Mol Toxicol 22:119-27. 2008
    ..male albino rats (n = 7) using (1)H NMR spectroscopy-based metabolic profile of rat serum and urine, serum enzyme tests, behavioral impairment, and histopathology of kidney and liver...
  61. ncbi Transcriptional control by galactose of a yeast gene encoding a protein homologous to mammalian aldo/keto reductases
    V Magdolen
    Institut fur Genetik und Mikrobiologie, Munich, F R G
    Gene 90:105-14. 1990
    ..b>Enzyme tests with AKR-specific substrates suggest that GCY encodes a carbonyl reductase.
  62. pmc Yield of diagnostic tests in evaluating syncopal episodes in older patients
    Mallika L Mendu
    Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520 8025, USA
    Arch Intern Med 169:1299-305. 2009
    ..We determined the frequency, yield, and costs of tests obtained to evaluate older persons with syncope. We also calculated the cost per test yield and determined whether the San Francisco syncope rule (SFSR) improved test yield...
  63. ncbi Hepatitis B: diagnosis and treatment
    Thad Wilkins
    Department of Family Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    Am Fam Physician 81:965-72. 2010
    ..Persons with chronic hepatitis B virus infection should be monitored for disease activity with liver enzyme tests and hepatitis B virus DNA levels; considered for liver biopsy; and entered into a surveillance program for ..
  64. doi "Enzyme Test Bench," a high-throughput enzyme characterization technique including the long-term stability
    Kirill Rachinskiy
    Department of Biochemical Engineering, Sammelbau Biologie, RWTH Aachen University, D 52074 Aachen, Germany
    Biotechnol Bioeng 103:305-22. 2009
    ..The concept of the Enzyme Test Bench consists of short term enzyme tests in 96-well microtiter plates under partly extreme conditions to predict the enzyme long term stability under ..
  65. ncbi Diagnosis and anti-infective therapy of periodontitis
    Hans Peter Horz
    Division of Oral Microbiology and Immunology, Department of Operative and Preventive Dentistry and Periodontology, University Hospital RWTH Aachen, Aachen, Germany
    Expert Rev Anti Infect Ther 5:703-15. 2007
    ..bacterial changes in the periodontal pocket, several techniques, namely microscopy, culture, immunoassays, enzyme tests and DNA-based techniques, have been established and the methods are described in the first part of this review...
  66. ncbi Retrobulbar adipocytes and humoral immunity in Graves' ophthalmopathy
    C Hansen
    III. Medizinische Klinik, Johannes-Gutenberg-Universitat, Klinikum Mainz, Germany
    Horm Metab Res 25:618-22. 1993
    ..By means of these specific enzyme tests no distinctions could be made between patients and controls...
  67. ncbi Assessing liver function
    Samir G Sakka
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Germany
    Curr Opin Crit Care 13:207-14. 2007
    ..This is a review on the techniques for assessing liver function in critically ill patients...
  68. ncbi Emended description of Campylobacter sputorum and revision of its infrasubspecific (biovar) divisions, including C. sputorum biovar paraureolyticus, a urease-producing variant from cattle and humans
    S L On
    Danish Veterinary Laboratory, Copenhagen, Denmark
    Int J Syst Bacteriol 48:195-206. 1998
    ..between the results of numerical analysis of protein profiles and the reaction of strains in certain enzyme tests was, however, noted. Therefore, it is proposed that the infrasubspecific (biovar) divisions of C...
  69. ncbi Current management of isolated sternal fractures in the UK: time for evidence based practice? A cross-sectional survey and review of literature
    M Hossain
    Department of Trauma and Orthopaedic Surgery, Ysbyty Gwynedd, UK
    Injury 41:495-8. 2010
    ..Chest X-ray was performed on admission in all hospitals. 57 hospitals performed ECG and cardiac enzyme tests prior to admission and 6 hospitals carried out echocardiogram following admission on a regular basis...
  70. ncbi Successful treatment of systemic amyloidosis with hepatic involvement and factor X deficiency by high dose melphalan chemotherapy and autologous stem cell reinfusion
    Dimitri A Breems
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Haematol 72:181-5. 2004
    ..high dose melphalan chemotherapy and autologous stem cell reinfusion, resulting in a normalization of the liver enzyme tests and the factor X level...
  71. ncbi Fibrogenesis in fatty liver associated with obesity and diabetes mellitus type 2
    Kaz Jaskiewicz
    Department of Pathology and General Surgery, University Medical School of Gdansk, Debinki7, Gdansk 80211, Poland
    Dig Dis Sci 53:785-8. 2008
    ..8 years. Patients with diabetes were older; had higher BMI, liver enzyme tests, glucose, cholesterol, and triglycerides; and lower albumin concentration...
  72. ncbi Prenatal diagnosis of Morquio disease type A using a simple fluorometric enzyme assay
    H Zhao
    Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
    Prenat Diagn 10:85-91. 1990
    ..These enzyme tests, as well as electrophoresis of glycosaminoglycans in the amniotic fluid, indicated affected fetuses in two ..
  73. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    Plasma liver-enzyme tests are widely used in the clinic for the diagnosis of liver diseases and for monitoring the response to drug treatment...
  74. ncbi Growth dependent enzymatic profiles of some gram-negative nonfermentative bacteria of clinical significance
    P Kamper
    Fachgebiet Hygiene, Technische Universitat Berlin
    Zentralbl Bakteriol Mikrobiol Hyg A 269:460-7. 1988
    ..Some of the enzyme tests may serve as additional valuable tools for differential diagnosis of the organisms investigated...
  75. ncbi A review of liver function tests during treatment with atypical antipsychotic drugs: a chart review study
    Nuray Atasoy
    Department of Psychiatry, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 31:1255-60. 2007
    ..In this article we aimed to evaluate the effect of atypical antipsychotic drugs namely olanzapine, risperidone and quetiapine on the hepatic enzymes and serum bilirubin levels in psychiatric patients...
  76. doi Whole-body MRI: a helpful diagnostic tool for juvenile dermatomyositis case report and review of the literature
    Nikolay Tzaribachev
    Division for Pediatric Rheumatology, Department for Pediatric Hematology, Oncology and General Pediatrics, University Children s Hospital, 72076 Tubingen, Germany
    Rheumatol Int 29:1511-4. 2009
    ..can be difficult especially under immunosuppressive therapy and in active disease without correlating muscle enzyme tests or functional muscle scores...
  77. ncbi Alcohol relapse after liver transplantation for alcoholic liver disease: does it matter?
    Georges Philippe Pageaux
    Fédération médico chirurgicale d Hépato gastroentérologie et Transplantation, Hopital Saint Eloi, 80 rue Augustin Fliche, 34295 CHU Montpellier Cedex 5, France
    J Hepatol 38:629-34. 2003
    ..The aim of this study was to distinguish the types of alcohol consumption after liver transplantation (LT) for alcoholic cirrhosis and to assess the consequences of heavy drinking...
  78. ncbi Value of the timing of informing the emergency department patients on cardiac test results: a randomized controlled study
    Mustafa Serinken
    Department of Emergency Medicine, Pamukkale University, School of Medicine, Denizli, Turkey
    Eur J Emerg Med 16:74-9. 2009
    ..information, and the value of its timing, provided to Emergency Department (ED) patients regarding cardiac enzyme tests (CET), on their personal concerns about their health status and their discussions with the emergency physicians ..
  79. ncbi Effect of waist circumference on reference intervals of liver-related enzyme tests in apparently healthy adult Mexican Americans, black and white Americans
    Nasser Samadi
    Institution University of Alberta Hospital, Canada
    Clin Biochem 40:206-12. 2007
    ....
  80. ncbi "Melanoma inhibitory activity" (MIA): a promising serological tumour marker in metastatic uveal melanoma
    I W Reiniger
    Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, Germany
    Graefes Arch Clin Exp Ophthalmol 243:1161-6. 2005
    ..To assess the role of "melanoma inhibitory activity" (MIA) as a potential serum marker for screening and detection of metastatic uveal melanoma...
  81. ncbi Mildly disturbed hepatic and pancreatic function during early abstention from alcohol is associated with brain atrophy and with disturbed psychometric performance
    Klaus Junghanns
    Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany
    Alcohol Alcohol 39:113-8. 2004
    ..To investigate the relation of liver status and pancreatic function to disorders of the central nervous system during early abstention from alcohol...
  82. ncbi Phenotypic degeneration occurs during sector formation in Metarhizium anisopliae
    M J Ryan
    Research School of Biosciences, University of Kent, Canterbury, UK
    J Appl Microbiol 93:163-8. 2002
    ..The aim of the investigation was to establish whether sector formation was accompanied by changes in physiological characters...
  83. ncbi Setting process control limits for enzyme tests in serum
    J A Lott
    Department of Pathology, The Ohio State University Medical Center, Columbus 43210, USA
    Scand J Clin Lab Invest 59:527-30. 1999
    ..Laboratorians must choose the approach that is appropriate for their laboratory and medical staff to meet medically perceived needs...
  84. ncbi Chitinolytic enzymes produced by ovine rumen bacteria
    J Kopecny
    Institute of Animal Physiology and Genetics, Academy of Sciences, Czech Republic, 104 00 Prague 10 Uhrínĕves, Czechia
    Folia Microbiol (Praha) 45:465-8. 2000
    ..b>Enzyme tests in cultures demonstrated endochitinase, exochitinase, N-acetyl-glucosaminidase, chitosanase and chitin ..
  85. ncbi The effects of heavy eccentric contractions on serum creatine kinase levels
    S S Lu
    Graduate Institute of Sports Science, National College of Physical Education and Sports, Taoyuan, Taiwan
    Chin J Physiol 35:35-44. 1992
    ..Due to large variations occurred during CK testing, follow-up study should try to establish baseline serum CK level by repeated enzyme tests.
  86. ncbi [Usefulness of NaCl/Enzyme Gel Test for the Identification of Unexpected Antibodies.]
    Jin Sol Lee
    Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea
    Korean J Lab Med 26:204-9. 2006
    ..To see if NaCl/Enzyme test is useful for the identification of antibodies, we compared the LISS/Coombs and NaCl/Enzyme tests for identification rates, and investigated an association between the frequency of each antibody and a history ..
  87. pmc Rapid and economical method for biochemical screening of stool isolates for Salmonella and Shigella species
    G Wilson
    Department of Medical Microbiology, Stirling Royal Infirmary, Stirling, Scotland, United Kingdom
    J Clin Microbiol 42:4821-3. 2004
    The LOUIS test is a screening protocol for Salmonella and Shigella that uses rapid enzyme tests. It had a sensitivity of 100% and a specificity of 94% and achieved presumptive reporting of Salmonella 3 h after colony isolation with ..
  88. ncbi Numerical phenetic classification of clinically significant aerobic sporoactinomycetes and related organisms
    Martha E Trujillo
    Department of Agricultural and Environmental Science, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Antonie Van Leeuwenhoek 84:39-68. 2003
    ..frequency matrix designed to facilitate the identification of clinically significant Actinomadura, Nocardiopsis and Streptomyces strains to the species level; rapid enzyme tests accounted for eleven out of the twenty-one diagnostic tests.
  89. doi Influence of genetic and non-genetic factors on the plasma concentrations of the clopidogrel metabolite (SR26334) among Chinese patients
    Haoming Zhou
    Department of Clinical Pharmacy and Pharmaceutical Management, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, China
    Clin Chim Acta 416:50-3. 2013
    ..Genotyping was carried out to identify the alleles of CYP2C19*2 and CYP2C19*3 by using PCR-based restriction enzyme tests. The plasma concentrations of SR26334 were determined using a rapid LC method with UV detection...
  90. ncbi A study of compliance with FDA recommendations for pemoline (Cylert)
    Mary E Willy
    Office of Drug Safety, Food and Drug Administration, Rockville, MD 20857, USA
    J Am Acad Child Adolesc Psychiatry 41:785-90. 2002
    To assess compliance with product labeling recommendations to use pemoline as second-line therapy for attention-deficit/hyperactivity disorder (ADHD) and to obtain baseline and biweekly liver enzyme tests.
  91. ncbi Liver enzyme monitoring in patients treated with troglitazone
    D J Graham
    Office of Postmarketing Drug Risk Assessment, US Food and Drug Administration, 5600 Fishers Ln, HFD 400, Room 15B 32, Rockville, MD 20857, USA
    JAMA 286:831-3. 2001
    ..Soon after initial marketing in March 1997, troglitazone, the first thiazolidinedione antidiabetic agent, was found to cause life-threatening acute liver failure. The drug was removed from the market in March 2000...
  92. ncbi Tacrolimus for the treatment of primary sclerosing cholangitis
    Jayant A Talwalkar
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Liver Int 27:451-3. 2007
    ..Results from a pilot investigation with tacrolimus for primary sclerosing cholangitis (PSC) demonstrated biochemical improvement without excessive drug toxicity. To date, no confirmatory study has been performed...
  93. ncbi Unusual presentation of cardiac sarcoidosis
    Harikrishna Tandri
    Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Congest Heart Fail 13:116-8. 2007
    ..Her electrocardiogram, showing sinus rhythm, was unremarkable, and serial cardiac enzyme tests excluded myocardial infarction...
  94. ncbi Investigation of a novel preparation of testosterone decanoate in men: pharmacokinetics and spermatogenic suppression with etonogestrel implants
    R A Anderson
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh, UK
    Contraception 66:357-64. 2002
    ..study was terminated after subjects had completed 12 to 18 weeks as some men were found to have elevated liver enzyme tests. These data demonstrate that the pharmacokinetics of TD are improved compared to previous injectable ..
  95. ncbi Measurement of ATP production and respiratory chain enzyme activities in mitochondria isolated from small muscle biopsy samples
    Rolf Wibom
    Centre for Inherited Metabolic Diseases, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Anal Biochem 311:139-51. 2002
    ..84-0.98; p<0.01). It is concluded that the set of methods is suitable for diagnosis of mitochondrial disorders in adults and small children...
  96. ncbi Lipase and pancreatic amylase versus total amylase as biomarkers of pancreatitis: an analytical investigation
    Majid Y Moridani
    Pathobiology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Clin Biochem 36:31-3. 2003
    ..To evaluate the biomarkers of pancreatitis Colorimetric Lipase, Total Amylase and Pancreatic Amylase (immunoinhibition) assays on the Roche COBAS INTEGRA 700...
  97. ncbi Correlation of cerebrospinal fluid beta-glucuronidase activity with plasma methotrexate concentrations in leukemic children receiving high-dose methotrexate
    Vasiliki Vlacha
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Patras, School of Medicine, General University Hospital, Patras, Greece
    Pediatr Blood Cancer 42:350-6. 2004
    ..Because chemotherapy also causes cell malfunction and death, for identifying a neurologic effect, we studied the activity of beta-glucuronidase in the cerebrospinal fluid (CSF) of leukemic children during treatment...
  98. ncbi A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus
    Elena Santagostino
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Division of Hepatology, IRCCS Maggiore Hospital, University of Milan, Via Pace 9, 20122 Milan, Italy
    Blood 102:78-82. 2003
    ....
  99. ncbi Autoimmune hepatitis following allogeneic PBSCT from an HLA-matched sibling
    T Ogose
    Department of Pediatrics, University of Tokushima School of Medicine, Japan
    Bone Marrow Transplant 31:829-32. 2003
    ..While rare, autoimmune hepatitis should be considered a potential long-term complication in patients with hepatic dysfunction in the late post-transplant phase...
  100. ncbi EUS yield in evaluating biliary dilatation in patients with normal serum liver enzymes
    Shahid Malik
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Dig Dis Sci 52:508-12. 2007
    ..Although the EUS yield is low in cases of biliary dilatation in the setting of normal serum liver enzymes, its preferential use would potentially avoid unnecessary MRCP and ERCP...
  101. ncbi Pseudoanaphylaxis
    W J Russell
    Department of Anaesthesia, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia
    Anaesth Intensive Care 34:801-3. 2006
    ..If the serum tryptase is elevated during the event but no allergic agent can be identified, a further serum tryptase should be taken several weeks later to exclude a persistent elevation due to mastocytosis...

Research Grants100

  1. OPTIMUM PATIENT POPULATION AND DOSING REGIMEN FOR TREAMENT OF HEPATITIS C
    Mitchell Shiffman; Fiscal Year: 2000
    ..The results may be complete response which will bring normal enzyme tests at the end of the therapy, no response, or relapse response which shows an initial response but elevated ..
  2. NALTREXONE TREATMENT OF ALCOHOL DEPENDENCE
    Joseph Volpicelli; Fiscal Year: 1992
    ..less alcohol craving, fewer days in which alcohol was consumed, fewer days of intoxication, and had lower liver enzyme tests and much lower rates of alcohol relapse...
  3. NALTREXONE TREATMENT OF ALCOHOL DEPENDENCE
    Joseph Volpicelli; Fiscal Year: 1993
    ..less alcohol craving, fewer days in which alcohol was consumed, fewer days of intoxication, and had lower liver enzyme tests and much lower rates of alcohol relapse...
  4. MEASURES TO TEST FEEDING TUBE PLACEMENT
    Norma Metheny; Fiscal Year: 1991
    ..This study's ultimate aim is to facilitate development of bedside enzyme tests to use in conjunction with pH tests to confirm proper tube position, thereby increasing patient safety in a ..
  5. SIMPLE DIAGNOSTIC SYSTEM FOR MYOCARDIAL INFARCTION
    ARTHUR BABSON; Fiscal Year: 1990
    ..Since electrocardiograms can often be misleading, a number of laboratory enzyme tests have been used to diagnose MI but these procedures are often not available at all hours...
  6. Clinical Decision Rule to Identify Children with Intra-Abdominal Injuries
    James Holmes; Fiscal Year: 2007
    ..unreadable]..
  7. Clinical Decision Rule to Identify Children with Intra-Abdominal Injuries
    James Holmes; Fiscal Year: 2008
    ..unreadable]..
  8. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2001
    ..Attempts will be made to obtain the high resolution crystal structure of the non-pancreatic PLA2 complexed with these inhibitors. This will permit a structure-based approach toward the design of more potent inhibitors. ..
  9. CATALYSIS BY 85-KDA MAMMALIAN PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 2003
    ..2) What protein surface constitutes the membrane binding element of the catalytic domain of cPLA2?; 3) How does the protein element that block access of the active site to substrate, the lid, re-position when cPLA2 binds to membranes? ..
  10. Mechanisms of Dihydroorotate Dehydrogenases
    Bruce Palfey; Fiscal Year: 2003
    ..The ubiquinone isoprenyl chain-length preference of the E. coli enzyme will be determined. Enzyme-ligand interactions will be probed with Raman spectroscopy. ..
  11. Mechanisms of Dihydroorotate Dehydrogenases
    Bruce Palfey; Fiscal Year: 2002
    ..The ubiquinone isoprenyl chain-length preference of the E. coli enzyme will be determined. Enzyme-ligand interactions will be probed with Raman spectroscopy. ..
  12. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2000
    ..Attempts will be made to obtain the high resolution crystal structure of the non-pancreatic PLA2 complexed with these inhibitors. This will permit a structure-based approach toward the design of more potent inhibitors. ..
  13. RETROVIRAL IMMUNOTOXINS FOR LEUKEMIA
    DANIEL VALLERA; Fiscal Year: 2001
    ..With the anti-C1498 effects that he has already established as a baseline, in the last aim he will ask whether or not important genetic modifications can improve retIT. ..
  14. MULTIPLEX ANALYSIS OF INBORN ERRORS OF METABOLISM
    Michael Gelb; Fiscal Year: 2000
    ..abstract_text> ..
  15. CATALYSIS BY 85-KDA MAMMALIAN PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 2001
    ..2) What protein surface constitutes the membrane binding element of the catalytic domain of cPLA2?; 3) How does the protein element that block access of the active site to substrate, the lid, re-position when cPLA2 binds to membranes? ..
  16. IMMUNOTOXINS IN BONE MARROW TRANSPLANTATION
    DANIEL VALLERA; Fiscal Year: 2001
    ..If successful, these approaches would be applied to the final design of a human homologue currently under development. ..
  17. IMMUNOTOXINS IN BONE MARROW TRANSPLANTATION
    DANIEL VALLERA; Fiscal Year: 2003
    ..If successful, these approaches would be applied to the final design of a human homologue currently under development. ..
  18. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2003
    ..Our overall goal is to develop new drugs for the treatment of parasitic diseases that cause suffering among millions of people worldwide. ..
  19. Mechanisms of Dihydroorotate Dehydrogenases
    Bruce Palfey; Fiscal Year: 2004
    ..The ubiquinone isoprenyl chain-length preference of the E. coli enzyme will be determined. Enzyme-ligand interactions will be probed with Raman spectroscopy. ..
  20. Flavoenzymes in Pyrimidine Metabolism
    Bruce A Palfey; Fiscal Year: 2010
    ..We will determine the substrate specificities of selected model DUSs and probe the interactions of the protein and tRNA by chemical and biophysical means. Project Description Page 6 ..
  21. Longitudinal Comparative Effectiveness & Safety of Biologics in Autoimmunity
    Jeffrey R Curtis; Fiscal Year: 2010
    ....
  22. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2009
    ..Malaria and African sleeping sickness kill about 2 million and 200,000 people, respectively, each year. New drugs are needed because existing drugs are either ineffective or resistance has developed. ..
  23. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Christophe L M J Verlinde; Fiscal Year: 2010
    ..Malaria and African sleeping sickness kill about 2 million and 200,000 people, respectively, each year. New drugs are needed because existing drugs are either ineffective or resistance has developed. ..
  24. Longitudinal Comparative Effectiveness & Safety of Biologics in Autoimmunity
    Jeffrey Curtis; Fiscal Year: 2009
    ....
  25. Flavoenzymes in Pyrimidine Metabolism
    Bruce A Palfey; Fiscal Year: 2010
    ..Our studies of the rates of the chemical reactions will identify important parts of the proteins, how they move during reactions, how they speed the synthesis of products, and how these reactions might be blocked. ..
  26. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2009
    ..Malaria and African sleeping sickness kill about 2 million and 200,000 people, respectively, each year. New drugs are needed because existing drugs are either ineffective or resistance has developed. ..
  27. Experimental Therapeutics for Brain Cancer
    DANIEL VALLERA; Fiscal Year: 2009
    ..In the second aim, we will use primates to determine the pharmacokinetics, distribution into non-target organs, and to study the dose limiting toxicities in a model that more closely approximates its use in humans. ..
  28. Flavoenzymes in Pyrimidine Metabolism
    Bruce Palfey; Fiscal Year: 2008
    ..Our studies of the rates of the chemical reactions will identify important parts of the proteins, how they move during reactions, how they speed the synthesis of products, and how these reactions might be blocked. ..
  29. Biochemical Studies of 14-kDa Phospholipases A2
    Michael Gelb; Fiscal Year: 2007
    ..We will also test the possibility that the M-type sPLA2 receptor functions to clear sPLA2s from the extracellular fluid once they have been secreted from cells. ..
  30. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2007
    ..Our overall goal is to develop new drugs for the treatment of parasitic diseases that cause suffering among millions of people worldwide. ..
  31. IMMUNOTOXINS IN BONE MARROW TRANSPLANTATION
    DANIEL VALLERA; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  32. Regulation and Function of Cytosolic Phospholipase A2
    Michael Gelb; Fiscal Year: 2006
    ..Such compounds will be useful as a tool to establish the functions of these paralogs in mammalian cells. ..
  33. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2006
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  34. CATALYSIS BY 85-KDA MAMMALIAN PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 2004
    ..2) What protein surface constitutes the membrane binding element of the catalytic domain of cPLA2?; 3) How does the protein element that block access of the active site to substrate, the lid, re-position when cPLA2 binds to membranes? ..
  35. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Christophe L M J Verlinde; Fiscal Year: 2010
    ..Malaria and African sleeping sickness kill about 2 million and 200,000 people, respectively, each year. New drugs are needed because existing drugs are either ineffective or resistance has developed. ..
  36. IMMUNOTOXINS IN BONE MARROW TRANSPLANTATION
    DANIEL VALLERA; Fiscal Year: 1999
    ..These studies should provide valuable insights into the clinical toxicities observed with current IT usage. ..
  37. MULTIPLEX ANALYSIS OF INBORN ERRORS OF METABOLISM
    Michael Gelb; Fiscal Year: 1999
    ..abstract_text> ..
  38. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 1999
    ..Attempts will be made to obtain the high resolution crystal structure of the non-pancreatic PLA2 complexed with these inhibitors. This will permit a structure-based approach toward the design of more potent inhibitors. ..
  39. INHIBITION OF TRYPANOSOMAL AND LEISHMANIAL GLYCOLYSIS
    Michael Gelb; Fiscal Year: 1999
  40. IMMUNOTOXINS IN HUMAN BONE MARROW TRANSPLANTATION
    DANIEL VALLERA; Fiscal Year: 1990
    ..Our major goals are 1) to develop protocols for the in vivo use of IT in the treatment of GVHD, leukemia, and graft promotion; 2) to optimize our in vitro IT protocols that are currently undergoing clinical evaluation...
  41. STUDIES IN ENZYMOLOGY USING INHIBITORS
    Michael Gelb; Fiscal Year: 1990
    ..We will also attempt to use isotope-edited NMR to determine the conformation of the bound inhibitor...
  42. IMMUNOTOXINS IN HUMAN BONE MARROW TRANSPLANTATION
    DANIEL VALLERA; Fiscal Year: 1992
    ..These studies should provide valuable insights into the clinical toxicities observed with current IT usage...
  43. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 1992
    ..Finally, we will prepare analogs of the yeast a-factor. This phermone has been recently shown to contain a farnesyl group and we will explore the role of the prenyl group in the recognition by the yeast a-factor receptor...
  44. CATALYSIS BY 85-KDA MAMMALIAN PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 2000
    ..6) A series of fatty acid analogs will be prepared and evaluated as selective and potent inhibitors of cPLA2. These inhibitors will be used as probes of the role of cPLA2 in cellular arachidonic acid mobilization. ..
  45. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 1991
    ..Finally, we will prepare analogs of the yeast a-factor. This phermone has been recently shown to contain a farnesyl group and we will explore the role of the prenyl group in the recognition by the yeast a-factor receptor...
  46. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2008
    ..Malaria and African sleeping sickness kill about 2 million and 200,000 people, respectively, each year. New drugs are needed because existing drugs are either ineffective or resistance has developed. ..
  47. Uppper Midwest Drug Hepatoxicity Consortium
    Jayant Talwalkar; Fiscal Year: 2008
    ..In turn, we are enthusiastic to work cooperatively with the Clinical Centers, the Data Coordinating Center, and sponsoring organizations in this expanded Network to oversee the implementation of and adherence to common protocols. ..
  48. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2000
    ....
  49. Regulation and Function of Cytosolic Phospholipase A2
    Michael Gelb; Fiscal Year: 2009
    ..The enzymes involved in generating free arachidonic acid, the precursor of the eicosanoids, are being identified, and their regulation is being studied. ..
  50. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 1993
    ..Finally, we will prepare analogs of the yeast a-factor. This phermone has been recently shown to contain a farnesyl group and we will explore the role of the prenyl group in the recognition by the yeast a-factor receptor...
  51. Nebraska Blood and Marrow Transplant Research Network
    Julie Vose; Fiscal Year: 2008
    ..End of abstract.) ..
  52. CATALYSIS BY 85-KDA MAMMALIAN PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 2002
    ..2) What protein surface constitutes the membrane binding element of the catalytic domain of cPLA2?; 3) How does the protein element that block access of the active site to substrate, the lid, re-position when cPLA2 binds to membranes? ..
  53. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2003
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  54. MULTIPLEX ANALYSIS OF INBORN ERRORS OF METABOLISM
    Michael Gelb; Fiscal Year: 2001
    ..abstract_text> ..
  55. ENZYMOLOGY OF PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 1993
    ..The results of these studies will be used to design and synthesize more potent inhibitors of the high MW PLA2s that. can be used in in vitro studies on the role of these enzymes in arachidonic acid generation...
  56. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2001
    ....
  57. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 1999
    ....
  58. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2004
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  59. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2002
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  60. Nebraska Blood and Marrow Transplant Research Network
    Julie Vose; Fiscal Year: 2007
    ..End of abstract.) ..
  61. CATALYSIS BY 85-KDA MAMMALIAN PHOSPHOLIPASE A2
    Michael Gelb; Fiscal Year: 1999
    ..6) A series of fatty acid analogs will be prepared and evaluated as selective and potent inhibitors of cPLA2. These inhibitors will be used as probes of the role of cPLA2 in cellular arachidonic acid mobilization. ..
  62. STUDIES IN ENZYMOLOGY USING INHIBITORS
    Michael Gelb; Fiscal Year: 1991
    ..We will also attempt to use isotope-edited NMR to determine the conformation of the bound inhibitor...
  63. Conference on Drug Against Tropical Protozoan Parasites
    Michael Gelb; Fiscal Year: 2002
    ..We consider the poster sessions that occur throughout our meeting to be just as important as the collection of lecture presentations. ..
  64. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2002
    ....
  65. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Michael Gelb; Fiscal Year: 2006
    ..Our overall goal is to develop new drugs for the treatment of parasitic diseases that cause suffering among millions of people worldwide. ..
  66. Regulation and Function of Cytosolic Phospholipase A2
    Michael Gelb; Fiscal Year: 2005
    ..Such compounds will be useful as a tool to establish the functions of these paralogs in mammalian cells. ..
  67. BIOCHEMICAL STUDIES OF 14 KDA PHOSPHOLIPASES A2
    Michael Gelb; Fiscal Year: 2005
    ..These studies will contribute to our fundamental understanding of how mammalian cells initiate the eicosanoid cascade. ..
  68. Regulation and Function of Cytosolic Phospholipase A2
    Michael Gelb; Fiscal Year: 2007
    ..Such compounds will be useful as a tool to establish the functions of these paralogs in mammalian cells. ..