differential diagnosis


Summary: Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.

Top Publications

  1. ncbi Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease
    G M McKhann
    Department of Neurology, Zanvyl Krieger Mind Brain Institute, Johns Hopkins University School of Medicine, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218 2685, USA
    Arch Neurol 58:1803-9. 2001
  2. ncbi Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society
    Heber Macmahon
    Radiology 237:395-400. 2005
  3. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
  4. ncbi Revised diagnostic criteria for neuromyelitis optica
    D M Wingerchuk
    Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Neurology 66:1485-9. 2006
  5. ncbi AGA technical review on nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine Virginia Commonwealth University Medical College of Virginia Richmond, Virginia, USA
    Gastroenterology 123:1705-25. 2002
  6. doi Differential diagnosis of hepatic tumors: value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid
    Kinuyo Hatanaka
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:61-9. 2008
  7. ncbi Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks
    R Swainson
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Dement Geriatr Cogn Disord 12:265-80. 2001
  8. ncbi A novel panel of cerebrospinal fluid biomarkers for the differential diagnosis of Alzheimer's disease versus normal aging and frontotemporal dementia
    A H Simonsen
    Biomarker Discovery Center Facility, Ciphergen Biosystems Inc, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 24:434-40. 2007
  9. ncbi Intraocular tuberculosis--an update
    Vishali Gupta
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Surv Ophthalmol 52:561-87. 2007
  10. doi Potential role of diffusion tensor MRI in the differential diagnosis of mild cognitive impairment and Alzheimer's disease
    Daniella B Parente
    Clinica de Diagnostico por Imagem, Ave das Américas 4666, sala 32522649 900, Rio de Janeiro, Brazil
    AJR Am J Roentgenol 190:1369-74. 2008

Detail Information

Publications429 found, 100 shown here

  1. ncbi Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease
    G M McKhann
    Department of Neurology, Zanvyl Krieger Mind Brain Institute, Johns Hopkins University School of Medicine, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218 2685, USA
    Arch Neurol 58:1803-9. 2001
    ..In addition, recommendations for the neuropathological criteria of FTD were reviewed, relative to classical neuropathology and modern molecular biology...
  2. ncbi Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society
    Heber Macmahon
    Radiology 237:395-400. 2005
  3. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
    ..The presence of soluble TREM-1 (sTREM-1) in bronchoalveolar-lavage fluid from patients receiving mechanical ventilation may be an indicator of pneumonia...
  4. ncbi Revised diagnostic criteria for neuromyelitis optica
    D M Wingerchuk
    Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Neurology 66:1485-9. 2006
    ..A serum autoantibody marker, NMO-IgG, is highly specific for NMO. The authors propose revised NMO diagnostic criteria that incorporate NMO-IgG status...
  5. ncbi AGA technical review on nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine Virginia Commonwealth University Medical College of Virginia Richmond, Virginia, USA
    Gastroenterology 123:1705-25. 2002
  6. doi Differential diagnosis of hepatic tumors: value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid
    Kinuyo Hatanaka
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka Sayama, Japan
    Intervirology 51:61-9. 2008
    To clarify the value of contrast-enhanced harmonic ultrasonography (US) with Sonazoid, a second-generation US contrast agent, in the differential diagnosis of liver tumors compared to dynamic CT.
  7. ncbi Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks
    R Swainson
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Dement Geriatr Cogn Disord 12:265-80. 2001
    ..AD, but they overlap with the cognitive impairments in other disorders such as depression, making differential diagnosis difficult...
  8. ncbi A novel panel of cerebrospinal fluid biomarkers for the differential diagnosis of Alzheimer's disease versus normal aging and frontotemporal dementia
    A H Simonsen
    Biomarker Discovery Center Facility, Ciphergen Biosystems Inc, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 24:434-40. 2007
    ..An early and accurate diagnosis of Alzheimer's disease (AD) is important in order to initiate symptomatic treatment with currently approved drugs and will be of even greater importance with the advent of disease-modifying compounds...
  9. ncbi Intraocular tuberculosis--an update
    Vishali Gupta
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Surv Ophthalmol 52:561-87. 2007
  10. doi Potential role of diffusion tensor MRI in the differential diagnosis of mild cognitive impairment and Alzheimer's disease
    Daniella B Parente
    Clinica de Diagnostico por Imagem, Ave das Américas 4666, sala 32522649 900, Rio de Janeiro, Brazil
    AJR Am J Roentgenol 190:1369-74. 2008
    ..The purpose of this study was to evaluate the fractional anisotropy values of several white matter tracts with the aim of differentiating a healthy population from persons with mild cognitive impairment or Alzheimer's disease...
  11. ncbi Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis
    Ian Brown
    Sullivan Nicolaides Pathology, Taringa, Queensland, Australia
    Arch Pathol Lab Med 130:1020-5. 2006
    ..A wide variety of immunologic stimuli can raise intraepithelial lymphocyte numbers. Among the other common associations are enteric infection, autoimmune disease, drugs, and gastric Helicobacter infection...
  12. ncbi Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging
    Natsuko Tsuda
    Business Unit Diagnostic Imaging, Nihon Schering K K, Nishimiyahara, Osaka, Japan
    Invest Radiol 42:242-7. 2007
    To investigate the potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for the differential diagnosis of nonalcoholic steatohepatitis (NASH) and fatty liver (FL).
  13. pmc A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer
    Jean Philippe Meyniel
    Department of Translational Research, Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    BMC Cancer 10:222. 2010
    ..The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathological diagnosis of ovarian tumors after a previous history of breast cancer...
  14. pmc Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis
    Chris C Tang
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Lancet Neurol 9:149-58. 2010
    ..We aimed to assess whether metabolic brain imaging combined with spatial covariance analysis could accurately discriminate patients with parkinsonism who had different underlying disorders...
  15. doi Granulomatous lung disease: an approach to the differential diagnosis
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Arch Pathol Lab Med 134:667-90. 2010
    ..Although most pathologists are aware of the need to exclude an infection in this setting, there is less familiarity with the specific histologic features that aid in the differential diagnosis.
  16. ncbi Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging
    Raymond Y Kwong
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 107:531-7. 2003
    ..Managing chest pain in the emergency department remains a challenge with current diagnostic strategies. We hypothesized that cardiac MRI could accurately identify patients with possible or probable acute coronary syndrome...
  17. ncbi Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arch Pathol Lab Med 130:1466-78. 2006
    ..They are believed to originate from interstitial cells of Cajal or related stem cells...
  18. ncbi Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis
    Liliana Simon
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Clin Infect Dis 39:206-17. 2004
    ..On the basis of this analysis, the diagnostic accuracy of PCT markers was higher than that of CRP markers among patients hospitalized for suspected bacterial infections...
  19. ncbi Comparison of multiplex-PCR and antigen detection for differential diagnosis of Entamoeba histolytica
    Helena Lucia Carneiro Santos
    Department of Pathology, Medical School, Fluminense Federal University, Niteroi, RJ
    Braz J Infect Dis 11:365-70. 2007
    ..histolytica cases. The results demonstrate the importance of the specific techniques use for the differentiation between E. histolytica and E. dispar...
  20. ncbi Thrombocytopenia in pregnancy: differential diagnosis, pathogenesis, and management
    Keith R McCrae
    Hematology Oncology, BRB3, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, OH 44106 4937, USA
    Blood Rev 17:7-14. 2003
    ..In this review, we discuss the differential diagnosis of the more common causes of pregnancy-associated thrombocytopenia, and provide an overview of approaches ..
  21. ncbi Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study
    Harald Hampel
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Gen Psychiatry 61:95-102. 2004
    ..Different tau phosphoepitopes can be sensitively detected in cerebrospinal fluid (CSF)...
  22. ncbi Olfaction and Parkinson's syndromes: its role in differential diagnosis
    Regina Katzenschlager
    The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Curr Opin Neurol 17:417-23. 2004
    ..We review recent advances related to its cause and its clinical relevance with respect to the differential diagnosis of Parkinsonian syndromes.
  23. ncbi Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma
    Ludmila Boudova
    Department of Pathology, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Blood 102:3753-8. 2003
    ..They are linked by a morphologic and probably a biologic continuum, which renders the differential diagnosis difficult...
  24. ncbi Real-time ultrasound elastography in the differential diagnosis of benign and malignant thyroid nodules
    Yurong Hong
    Second Affiliated Hospital, Zhejiang University College of Medicine, Zhejiang, China
    J Ultrasound Med 28:861-7. 2009
    ..The purpose of this study was to evaluate the diagnostic utility of real-time ultrasound elastography in differentiating benign from malignant thyroid nodules...
  25. doi US-elastography in the differential diagnosis of benign and malignant thyroid nodules
    Carmela Asteria
    Department of Experimental Endocrinology and Cardiovascular Prevention, Policlinico Multimedica, IRCCS, Milan, Sesto San Giovanni, Italy
    Thyroid 18:523-31. 2008
    ..This technique has previously been shown to be useful in the differential diagnosis between benign and malignant tumors.
  26. pmc DNA differential diagnosis of taeniasis and cysticercosis by multiplex PCR
    Hiroshi Yamasaki
    Department of Parasitology Animal Laboratory for Medical Research, Asahikawa Medical College, Asahikawa, Japan
    J Clin Microbiol 42:548-53. 2004
    Multiplex PCR was established for differential diagnosis of taeniasis and cysticercosis, including their causative agents...
  27. doi Differential diagnosis of hepatocellular carcinoma from metastatic tumors in the liver using microRNA expression
    Iris Barshack
    Department of Pathology, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Int J Biochem Cell Biol 42:1355-62. 2010
    ..This differential diagnosis can be difficult because metastatic cancers in the liver, especially adenocarcinomas, may mimic the ..
  28. ncbi FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
    Norman L Foster
    Center for Alzheimer s Care, Imaging and Research and Department of Neurology, University of Utah, USA
    Brain 130:2616-35. 2007
    ..fluorodeoxyglucose (FDG-PET) shows different patterns of hypometabolism in these disorders that might aid differential diagnosis. Six dementia experts with variable FDG-PET experience made independent, forced choice, diagnostic ..
  29. doi Added value and diagnostic performance of intratumoral susceptibility signals in the differential diagnosis of solitary enhancing brain lesions: preliminary study
    H S Kim
    Department of Diagnostic Radiology, Ajou University School of Medicine, Suwon, Korea
    AJNR Am J Neuroradiol 30:1574-9. 2009
    ..The purpose of this study was to determine the added value and diagnostic performance of HR-SWI for differentiating solitary enhancing brain lesions (SELs) by assessing intratumoral susceptibility signals (ITSSs)...
  30. doi Glossopharyngeal neuralgia: neurosurgical treatment and differential diagnosis
    M J Teixeira
    Pain Center, Neurology Department, Hospital das Clinicas, Medical School, University of Sao Paulo, SP, Brazil
    Acta Neurochir (Wien) 150:471-5; discussion 475. 2008
    ..objective of this study was to review the literature on glossopharyngeal neuralgia (GN) and to discuss its differential diagnosis and treatment options...
  31. ncbi Myofascial pain associated to trigger points: a literature review. Part 2: differential diagnosis and treatment
    Eduardo Vazquez-Delgado
    TMJ Disease and Orofacial Pain Unit of Master of Oral Surgery Degree Program, University of Kentucky Dental School, USA
    Med Oral Patol Oral Cir Bucal 15:e639-43. 2010
    ..Many clinical conditions are included in the differential diagnosis of myofascial pain associated to trigger points...
  32. ncbi Comparative study of conventional colonoscopy, chromoendoscopy, and narrow-band imaging systems in differential diagnosis of neoplastic and nonneoplastic colonic polyps
    Ming Yao Su
    Department of Gastroenterology and Hepatology, Lin Kou Medical Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Am J Gastroenterol 101:2711-6. 2006
    ..To identify the feasibility of the narrow-band imaging (NBI) method compared with that of conventional colonoscopy and chromoendoscopy for distinguishing neoplastic and nonneoplastic colonic polyps...
  33. doi DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, NW, Building 54, Room G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1401-8. 2009
    ..DOG1 should be added into the diagnostic panel evaluating GI and other abdominal tumors, but limitations in its sensitivity and specificity should be recognized...
  34. ncbi Characterization of neoplastic and normal human breast tissues with in vivo (1)H MR spectroscopy
    K A Kvistad
    MR Center, Medical Division, University Hospital, N 7006 Trondheim, Norway
    J Magn Reson Imaging 10:159-64. 1999
    ..Analysis of lipid signals did not contribute to differentiation between various breast lesions and tissues. J. Magn. Reson. Imaging 1999;10:159-164...
  35. ncbi Burkitt's lymphoma: clinicopathologic features and differential diagnosis
    Judith A Ferry
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital and the Department of Pathology, Harvard Medical School, Boston, 02114, USA
    Oncologist 11:375-83. 2006
    ..The differential diagnosis of Burkitt's lymphoma is broad, and precise diagnosis based on histologic, immunophenotypic, and genetic ..
  36. doi Levels of brain related proteins in cerebrospinal fluid: an aid in the differential diagnosis of parkinsonian disorders
    Radu Constantinescu
    Department of Neurology, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    Parkinsonism Relat Disord 15:205-12. 2009
    ..The initial differential diagnosis can be extremely challenging with major implications for prognosis...
  37. ncbi Clinicopathological correlates in frontotemporal dementia
    John R Hodges
    Prince of Wales Medical Research Institute, The University of New South Wales, Randwick, New South Wales, Australia
    Ann Neurol 56:399-406. 2004
    ..Therefore, the pathological substrate can be predicted in a significant proportion of FTD patients, which has important implications for studies targeting mechanistic treatments...
  38. ncbi Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues
    Thomas M Ulbright
    Department of Pathology and Laboratory Medicine, Clarian Health Partners and Indiana University School of Medicine, Indianapolis, IN 46202 5280, USA
    Mod Pathol 18:S61-79. 2005
  39. ncbi Does combined imaging of the pre- and postsynaptic dopaminergic system increase the diagnostic accuracy in the differential diagnosis of parkinsonism?
    Walter Koch
    Department of Nuclear Medicine, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Eur J Nucl Med Mol Imaging 34:1265-73. 2007
    ..quantitative information about the dopaminergic system would provide a higher diagnostic accuracy in the differential diagnosis of parkinsonism than specific striatal D(2) receptor binding alone...
  40. pmc Differential diagnosis of suspected multiple sclerosis: a consensus approach
    D H Miller
    Department of Inflammation, Institute of Neurology, NMR Research Unit, University College London, UK
    Mult Scler 14:1157-74. 2008
    ..A systematic process for exclusion of alternative diagnoses has not been defined. An International Panel of MS experts developed consensus perspectives on MS differential diagnosis.
  41. doi Two newly proposed infectious encephalitis/encephalopathy syndromes
    Jun ichi Takanashi
    Department of Pediatrics, Kameda Medical Center, 929 Higashi Cho, Kamogawa shi, Chiba 296 8602, Japan
    Brain Dev 31:521-8. 2009
    ..The reason for the transiently reduced diffusion within the lesions is unknown; possibilities that have been postulated include intramyelinic edema, interstitial edema in tightly packed fibers, and a transient inflammatory infiltrate...
  42. ncbi F-18-fluorodeoxyglucose (FDG) positron-emission tomography of Echinococcus multilocularis liver lesions: prospective evaluation of its value for diagnosis and follow-up during benzimidazole therapy
    K D M Stumpe
    Clinic of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Infection 35:11-8. 2007
    ..Recently, AE liver lesions were reported to exhibit increased F-18-fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET). To assess the value of FDG-PET for diagnosis and follow-up of AE patients...
  43. ncbi Diagnostic accuracy of blood lactate-to-pyruvate molar ratio in the differential diagnosis of congenital lactic acidosis
    François Guillaume Debray
    Department of Pediatrics, Ste Justine Hospital, Universite de Montreal, Montreal, Quebec, Canada
    Clin Chem 53:916-21. 2007
  44. ncbi Suspicious minds: the psychology of persecutory delusions
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Clin Psychol Rev 27:425-57. 2007
    ..Ten key future research questions are identified, including the need for researchers to consider factors important to the different dimensions of delusional experience...
  45. pmc Systematic review of factors influencing patient and practitioner delay in diagnosis of upper gastrointestinal cancer
    S Macdonald
    General Practice and Primary Care, Division of Community Based Sciences, University of Glasgow, 1 Horselethill Road, Glasgow G12 9LX, UK
    Br J Cancer 94:1272-80. 2006
    ..Greater understanding of patient factors is required, along with evaluation of interventions to ensure appropriate diagnosis, examination and investigation...
  46. ncbi Differentiation between benign and malignant findings on MR-mammography: usefulness of morphological criteria
    U Wedegärtner
    Abteilung für Röntgendiagnostik, Radiologische Klinik, Universitats Krankenhaus Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Eur Radiol 11:1645-50. 2001
    ..35 and 0.4. Morphological criteria are useful features in MR-mammography for differentiating between benign and malignant lesions. However, due to the relatively high interobserver variability, standardization of terminology is important...
  47. ncbi A critical evaluation of obsessive-compulsive disorder subtypes: symptoms versus mechanisms
    Dean McKay
    Department of Psychology, Fordham University, 441 East Fordham Road, Bronx, NY 10458 5198, USA
    Clin Psychol Rev 24:283-313. 2004
    ..The research is critically examined and implications for treatment are discussed. Recommendations for future investigations are offered...
  48. ncbi Autoimmune hepatitis
    Edward L Krawitt
    Department of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
    N Engl J Med 354:54-66. 2006
  49. doi Benign childhood focal epilepsies: assessment of established and newly recognized syndromes
    Chrysostomos P Panayiotopoulos
    Department of Clinical Neurophysiology and Epilepsies, St Thomas Hospital, London, UK
    Brain 131:2264-86. 2008
    ..Taking all these into account, benign childhood focal seizures and related epileptic syndromes would need proper multi-disciplinary re-assessment in an evidence-based manner...
  50. ncbi Diffusion-weighted imaging in the follow-up of treated high-grade gliomas: tumor recurrence versus radiation injury
    Patrick A Hein
    Section of Radiation Oncology, Norris Cotton Cancer Center, Lebanon, NH, USA
    AJNR Am J Neuroradiol 25:201-9. 2004
    ..We hypothesized that DW imaging has the potential to differentiate recurrent or progressive tumor growth from treatment-induced damage to brain parenchyma in high-grade gliomas after radiation therapy...
  51. ncbi Current status of breast MR imaging. Part 2. Clinical applications
    Christiane K Kuhl
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Radiology 244:672-91. 2007
    ..A discussion is provided on the many controversies that exist regarding breast MR imaging for preoperative staging and for screening...
  52. ncbi Application of the TIMI risk score for unstable angina and non-ST elevation acute coronary syndrome to an unselected emergency department chest pain population
    Charles V Pollack
    Department of Emergency Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA
    Acad Emerg Med 13:13-8. 2006
  53. ncbi Evaluation of lymph node perfusion using continuous mode harmonic ultrasonography with a second-generation contrast agent
    Leopoldo Rubaltelli
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padua, Padua, Italy
    J Ultrasound Med 23:829-36. 2004
  54. pmc Genotype-phenotype correlations of 39 patients with Cornelia De Lange syndrome: the Dutch experience
    Z A Bhuiyan
    Department of Clinical Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Med Genet 43:568-75. 2006
    ..Recently mutations in NIPBL, the human homologue of the Drosophila Nipped-B gene, were found to cause CdLS. Mutations have been found in 39% of reported cases...
  55. ncbi Characterization of lesions of the breast with proton MR spectroscopy: comparison of carcinomas, benign lesions, and phyllodes tumors
    Gary M K Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Ngan Shing St, Shatin, Hong Kong, SAR China
    AJR Am J Roentgenol 181:1267-72. 2003
    ..All lesions were larger than 1.5 cm. Tumor Ki-67 proliferative index, tumor angiogenesis, and HER2/neu oncogene overexpression were evaluated by immunohistochemistry of the histologic material...
  56. ncbi Evaluation of early-stage Parkinson's disease with 99mTc-TRODAT-1 imaging
    W S Huang
    Department of Nuclear Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
    J Nucl Med 42:1303-8. 2001
    ..CONCLUSION: For clinical practice, 99mTc-TRODAT-1 may serve as a useful imaging agent for the early detection of Parkinson's disease...
  57. ncbi Differential diagnosis of tumours and tumour-like lesions of the infrapatellar (Hoffa's) fat pad: pictorial review with an emphasis on MR imaging
    C Helpert
    Department of Radiology, MRI Centre, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK
    Eur Radiol 14:2337-46. 2004
    ..This pictorial review illustrates the spectrum of mass-like lesions that can affect the IFP, emphasizing the radiographic and MR findings that suggest a specific diagnosis...
  58. doi Value of autoantibody analysis in the differential diagnosis of chronic cholestatic liver disease
    Piotr Milkiewicz
    Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Gastroenterol Hepatol 7:1355-60. 2009
  59. pmc Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle
    H M Vordermeier
    TB Research Group, Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone KT15 3NB, United Kingdom
    Clin Diagn Lab Immunol 8:571-8. 2001
    ..In summary, our results demonstrate that this peptide cocktail can discriminate between M. bovis infection and BCG vaccination with a high degree of sensitivity and specificity...
  60. ncbi Congenital malaria, an important differential diagnosis to consider when evaluating febrile infants of immigrant mothers
    Stefan Hagmann
    Division of Pediatric Infectious Diseases, Bronx Lebanon Hospital Center, Bronx, NY 10457, USA
    Pediatr Emerg Care 23:326-9. 2007
    ..Because of its nonspecific presentation with fever during the first 3 months of life, it is an important differential diagnosis when evaluating such infants with fever in the pediatric emergency department...
  61. doi Comparative study of conventional colonoscopy, magnifying chromoendoscopy, and magnifying narrow-band imaging systems in the differential diagnosis of small colonic polyps between trainee and experienced endoscopist
    Chun Chao Chang
    Division of Gastroenterology, Department of Internal Medicine, Taipei Medical University Hospital and Digestive Disease Research Center, Taipei, Taiwan
    Int J Colorectal Dis 24:1413-9. 2009
    ..We compared the ability of a trainee and an experienced endoscopist in distinguishing between neoplastic polyps and nonneoplastic polyps by conventional white-light, magnifying narrow-band imaging (NBI), and magnifying chromoendoscopy...
  62. doi Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasound
    Li Da Chen
    Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat Sen University, 58 Zhongshan Road 2, Guangzhou 510080, China
    Eur Radiol 20:743-53. 2010
    ..We assessed the usefulness of contrast-enhanced ultrasound (CEUS) in the differentiation of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC)...
  63. ncbi Adrenal masses: characterization with combined unenhanced and delayed enhanced CT
    Elaine M Caoili
    Department of Radiology, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 9723, USA
    Radiology 222:629-33. 2002
    ..To assess the accuracy of a dedicated adrenal computed tomographic (CT) protocol...
  64. ncbi The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis
    R Mark Sadler
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Adv Neurol 97:27-37. 2006
  65. pmc CSF neurofilament proteins in the differential diagnosis of dementia
    D De Jong
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 78:936-8. 2007
    ..Neurofilament (NF) proteins are major cytoskeletal constituents of neurons. Increased CSF NF levels may reflect neuronal degeneration...
  66. ncbi Abdominal tuberculosis: diagnosis by laparoscopy and colonoscopy
    Md Ibrarullah
    Department of Surgical Gastroenterology, SV Institute of Medical Sciences, Tirupati 517 507, AP, India
    Trop Gastroenterol 23:150-3. 2002
    ..Peritoneoscopy and colonoscopy provide semi-invasive access to the peritoneum, large intestine and ileocecal area. Information on the diagnostic yield of these two investigation in abdominal tuberculosis is scarce...
  67. ncbi Differential diagnosis of large periapical lesions using cone-beam computed tomography measurements and biopsy
    James H S Simon
    Division of Surgical Therapeutic and Bioengineering Sciences, School of Dentistry, University of Southern California, Los Angeles, CA 90089 0641, USA
    J Endod 32:833-7. 2006
    This study compared the differential diagnosis of large periapical lesions (granuloma versus cyst) to traditional biopsy using Cone Beam Computed Tomography (CBCT), the NewTom 3G...
  68. ncbi Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis
    Asim Ejaz
    Department of Pathology and Laboratory Medicine, Continuum Hospitals of New York Beth Israel Medical Center and Saint Luke s Roosevelt Hospitals, New York, New York 10003, USA
    Adv Anat Pathol 12:134-43. 2005
  69. ncbi Diagnosis and differential diagnosis of trigeminal neuralgia
    Joanna M Zakrzewska
    Barts and The London, Queen Mary s School of Medicine and Dentistry, London, England, UK
    Clin J Pain 18:14-21. 2002
    ..Their specificity and sensitivity regarding compressions found at the time of surgery is reviewed. Other differential diagnoses for chronic unilateral orofacial pain are discussed...
  70. ncbi Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease
    M Otto
    Neurologische Klinik und Poliklinik, Georg August Universitat Gottingen, Germany
    Neurology 58:192-7. 2002
    ..Both tests in a larger group of patients with the differential diagnosis of CJD were evaluated.
  71. ncbi Asthma and chronic obstructive pulmonary disease exhibit common origins in any country!
    Monica Kraft
    Am J Respir Crit Care Med 174:238-40; discussion 243-4. 2006
  72. ncbi Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation
    S Minoshima
    Department of Internal Medicine, University of Michigan Medical School, Geriatrics Research, Education, and Clinical Center, Ann Arbor, USA
    Ann Neurol 50:358-65. 2001
    ..In these patients, occipital hypometabolism preceded some clinical features of DLB. Occipital hypometabolism is a potential antemortem marker to distinguish DLB versus AD...
  73. ncbi Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease
    A J Hughes
    United Kingdom Parkinson's Disease Society Brain Research Centre, Institute of Neurology, London, UK
    Neurology 57:1497-9. 2001
    ..Assessment of the clinical features suggests that an accuracy of 90% may be the highest that can be expected using current diagnostic criteria...
  74. doi Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications
    Olca Basturk
    Department of Pathology, New York University, New York, New York, USA
    Arch Pathol Lab Med 133:423-38. 2009
    ..Consequently, in the past 2 decades, the nature of many cystic tumors in this organ has been better characterized, and significant developments have taken place in the classification and in our understanding of pancreatic cystic lesions...
  75. pmc Differential diagnosis of Trichostrongylus and hookworm eggs via PCR using ITS-1 sequence
    Tai Soon Yong
    Department of Parasitology and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120 752, Korea
    Korean J Parasitol 45:69-74. 2007
    ..duodenale and N. americanus from the eggs of each (520 bp, 690 bp, and 870 bp, respectively). A species-specific PCR technique can be developed in order to study the epidemiology of Trichostrongylus spp. and hookworms in endemic areas...
  76. ncbi Fabry disease defined: baseline clinical manifestations of 366 patients in the Fabry Outcome Survey
    A Mehta
    University College London, London, UK
    Eur J Clin Invest 34:236-42. 2004
    ..This paper presents the first analysis of the FOS database and provides essential baseline data against which the effects of enzyme replacement can be measured...
  77. ncbi Inflammatory pseudotumor of the liver: demographics, diagnosis, and the case for nonoperative management
    Jonathan B Koea
    Upper Gastrointestinal Hepatobiliary Unit, Department of Surgery, Auckland Hospital, Auckland, New Zealand
    J Am Coll Surg 196:226-35. 2003
    Inflammatory pseudotumor of the liver (IPL) is an unusual tumor-like condition that is becoming recognized as an important differential diagnosis in the patient presenting with liver masses. This report describes six cases of IPL.
  78. doi Performance of transient elastography for the staging of liver fibrosis: a meta-analysis
    Mireen Friedrich-Rust
    Department of Internal Medicine I, J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 134:960-74. 2008
    ..A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy...
  79. ncbi Rapid and differential diagnosis of foot-and-mouth disease, swine vesicular disease, and vesicular stomatitis by a new multiplex RT-PCR assay
    Jovita Fernández
    Centro de Investigación en Sanidad Animal CISA INIA, Valdeolmos, Madrid, Spain
    J Virol Methods 147:301-11. 2008
    ..experimentally, showing the suitability of the method for a rapid (less than 6h), sensitive and specific differential diagnosis in clinical samples...
  80. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  81. ncbi Quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesion
    C Marini
    Department of Diagnostic and Interventional Radiology, University of Pisa, Via Roma 67, 56100, Pisa PI, Italy
    Eur Radiol 17:2646-55. 2007
    ..Quantitative DWI is not time-consuming and can be easily inserted into standard clinical breast MR imaging protocols...
  82. ncbi The diagnosis of Parkinson's disease
    Eduardo Tolosa
    Neurology Service, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet Neurol 5:75-86. 2006
    ..Also genetic testing and various other ancillary tests, such as olfactory testing, MRI, and dopamine-transporter single-photon-emission computed-tomography imaging, help with clinical diagnostic decisions...
  83. doi Differential diagnosis of adults with ADHD: the role of executive function and self-regulation
    Russell A Barkley
    Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA
    J Clin Psychiatry 71:e17. 2010
    ..Understanding the ways in which deficits in executive function contribute to the symptoms of ADHD can help in differentiating ADHD from disorders that share similar characteristics...
  84. pmc Detection of anti-arboviral immunoglobulin G by using a monoclonal antibody-based capture enzyme-linked immunosorbent assay
    A J Johnson
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Clin Microbiol 38:1827-31. 2000
    ..The tests were standardized for laboratory diagnosis of arboviral infections, with the intent that they be used in tandem with the corresponding IgM antibody-capture ELISAs...
  85. doi Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps
    Yasushi Sano
    Gastrointestinal Center, Sano Hospital, Kobe, Hyogo, Japan
    Gastrointest Endosc 69:278-83. 2009
    ..Although microvascular vessels on the surface of colorectal polyps are observed by narrow-band imaging (NBI) with magnification, its clinical usefulness is still uncertain...
  86. ncbi Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count
    Baha M Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Obstet Gynecol 103:981-91. 2004
    ..Recommendation for diagnosis, management, and counseling of these women is also provided based on results of recent studies and my own clinical experience...
  87. doi Female genital schistosomiasis--a differential diagnosis to sexually transmitted disease: genital itch and vaginal discharge as indicators of genital Schistosoma haematobium morbidity in a cross-sectional study in endemic rural Zimbabwe
    Eyrun Floerecke Kjetland
    Centre for Imported and Tropical Diseases, Ullevaal University Hospital, Oslo, Norway
    Trop Med Int Health 13:1509-17. 2008
    ..To examine the association between schistosomiasis and reproductive tract symptoms...
  88. ncbi The histopathology of coeliac disease: time for a standardized report scheme for pathologists
    G Oberhuber
    Department of Clinical Pathology, University of Vienna, Medical School, Austria
    Eur J Gastroenterol Hepatol 11:1185-94. 1999
    ..The most important histological differential diagnoses are given, as well as a definition of the different clinical forms of coeliac disease such as symptomatic, silent, latent, potential, treated and refractory coeliac disease...
  89. ncbi Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 438:1-12. 2001
    ..Angiosarcomas and metastatic melanomas, both of which are often KIT-positive, should not be confused with GISTs...
  90. ncbi Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management
    Yi Sheng Chang
    Department of Ophthalmology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Cornea 26:123-9. 2007
    ..To study the acute ocular/cutaneous manifestations, causes, and management of the erythema multiforme (EM)/Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) disease spectrum...
  91. ncbi Molecular diagnostics of viral hemorrhagic fevers
    Christian Drosten
    Department of Virology, Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Antiviral Res 57:61-87. 2003
    ..The third part is focussed on important differential diagnoses of VHF...
  92. ncbi Inflammatory pseudotumor
    Lakshmana Das Narla
    Department of Radiology, Medical College of Virginia VCU Health System, Main Hospital 3rd Fl, 1250 E Marshall St, Richmond, VA 23298, USA
    Radiographics 23:719-29. 2003
    ..Because inflammatory pseudotumors mimic malignant tumors both clinically and radiologically, the radiologist should be familiar with this entity and help avoid unnecessary radical surgery when possible...
  93. ncbi Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions
    A Bartolazzi
    Department of Oncology Pathology, Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, CCK R8 04 Karolinska Hospital, 17176, Stockholm, Sweden
    Lancet 357:1644-50. 2001
    ..We undertook an international multicentre study to assess the usefulness of immunohistocytochemical staining for two potential markers of malignant thyrocytes...
  94. ncbi Neuroendocrine differentiated breast carcinoma: imaging features correlated with clinical and histopathological findings
    Işil Gunhan-Bilgen
    Department of Radiology, Ege University Hospital, Bornova, 35100 Izmir, Turkey
    Eur Radiol 13:788-93. 2003
    ..Neuroendocrine differentiated breast carcinoma should be included in the differential diagnosis of mammographically dense, round masses with predominantly spiculated or lobulated margins...
  95. doi Diagnosis and differential diagnosis of fibromyalgia
    Don L Goldenberg
    Department of Rheumatology, Newton Wellesley Hospital, Newton, Massachusetts 02462, USA
    Am J Med 122:S14-21. 2009
    ..Until a better clinical case definition of fibromyalgia exists, all diagnostic criteria should be interpreted with caution, considered rudimentary, and subject to modification...
  96. ncbi Chromoendoscopy using indigo carmine dye spraying with magnifying observation is the most reliable method for differential diagnosis between non-neoplastic and neoplastic colorectal lesions: a prospective study
    K I Fu
    Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Endoscopy 36:1089-93. 2004
    b>Differential diagnosis between non-neoplastic and neoplastic lesions is very important at colonoscopy, since removal or biopsy of non-neoplastic polyps wastes time and resources...
  97. ncbi Against the Dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases
    Peter J Barnes
    Am J Respir Crit Care Med 174:240-3; discussion 243-4. 2006
  98. ncbi Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy
    L L Cheng
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02129, USA
    J Magn Reson 135:194-202. 1998
    ..Our results suggest that biochemical markers thus measured may function as a valuable adjunct to histopathology to improve the accuracy of and reduce the time frame required for the diagnosis of human breast cancer...
  99. ncbi CT screening for lung cancer: suspiciousness of nodules according to size on baseline scans
    Claudia I Henschke
    Department of Radiology and Medicine, Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Radiology 231:164-8. 2004
    ..0 mm in diameter identified on initial computed tomographic (CT) images at baseline screening leads to a diagnosis of malignancy prior to first annual repeat screening, compared with a possibly optimal work-up of larger nodules...
  100. ncbi Diagnosis and management of superficial bladder cancer
    C L Amling
    Department of Urology, Naval Medical Center, San Diego, California, USA
    Curr Probl Cancer 25:219-78. 2001
    ..With the development of orthotopic lower urinary tract reconstruction to the native urethra, the quality of life impact of radical cystectomy has been lessened...
  101. ncbi Enigmatic Kikuchi-Fujimoto disease: a comprehensive review
    Xavier Bosch
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain
    Am J Clin Pathol 122:141-52. 2004
    ..There is an abundance of T cells with predominance of CD8+ over CD4+ T cells. Differential diagnosis includes lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma...

Research Grants71

    Douglas H Keefe; Fiscal Year: 2013
    ..The research also evaluates whether the test battery improves the accuracy of diagnosing middle-ear disease and of identifying hearing loss in adult patients who receive medications that may affect their hearing. ..
  2. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2013
    ..phosphate and vitamin D supplementation;whereas osteomalacia requires a more detailed evaluation, as the differential diagnosis is extensive, and each disease entity requires a somewhat different treatment approach...
  3. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2011
    ..phosphate and vitamin D supplementation;whereas osteomalacia requires a more detailed evaluation, as the differential diagnosis is extensive, and each disease entity requires a somewhat different treatment approach...
  4. Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort Study
    Karen Bonuck; Fiscal Year: 2009
    ..Neither they, nor sub-specialists in pediatric GF routinely include upper airway obstruction in their differential diagnosis of GF...
  5. Measuring Altered Social Behavior in Neurodegenerative Disease
    Katherine P Rankin; Fiscal Year: 2013
    ..The resulting battery could be used by clinicians 1) to aid in the differential diagnosis of dementia;2) to provide treatment interventions, prognostic information, and caregiver support based on ..
  6. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..better understanding of structure-function relationships in normal and pathological middle ears, improved differential diagnosis of conductive hearing loss, and optimization of surgical techniques and hearing results...
  7. Identifying the Neural Basis and Functional Role of Emotional Empathy in Dementia
    VIRGINIA EMILY STURM; Fiscal Year: 2013
    ..support necessary to accomplish the following goals: (1) to gain expertise in neurodegenerative disease, differential diagnosis, and behavioral neurology;(2) to advance her knowledge of psychophysiology by learning a new method, ..
  8. How can caspases control intracellular pulmonary pathogens
    Amal O Amer; Fiscal Year: 2010
    ..Therefore, Legionella infection should be considered in the differential diagnosis of any patient with pneumonia...
  9. Step2 CS Training in Alcohol Addiction and the Medical Consequences of Alcohol
    MARY P METCALF; Fiscal Year: 2012
    ..actor, request additional data from the sEMR (history, consults, laboratories, physical findings), build a differential diagnosis, and convey diagnostics choices, including treatment plans, to the RLSP...
    GARY WILLIAM SMALL; Fiscal Year: 2010
    ..and genetic risk (apolipoprotein E-4 [APOE-4], H1 haplotype of the tau gene) measures in diagnosis and differential diagnosis of normal aging and dementia...
    Richard K Olson; Fiscal Year: 2013
  12. Comprehensive Molecular Diagnosis for Food and Waterborne Enteropathogens
    Eric R Houpt; Fiscal Year: 2011
    ..for referral public health laboratories to detect the multiplicity of potential pathogens that inhabit the differential diagnosis of a food or waterborne diarrheal outbreak...
  13. International collaborative research to develop quantitive sensory testing guidel
    Mark Drangsholt; Fiscal Year: 2009
    ..taste tools developed through this research to provide evidence-based criteria and methods to improve the differential diagnosis, classification, prognostic prediction and treatment of chronic, persistent, intra-oral pain conditions...
  14. Speech-based biomarkers of CNS dysfunction associated with early Alzheimers disea
    James C Mundt; Fiscal Year: 2012
    ..is to support the development and validation of potential screening measures that could be used for differential diagnosis in clinical practice, as well as provide a foundation for innovative assessment and management approaches ..
  15. Detection of Light Chain Restriction in non-Hodgkin Lymphoma by a Novel RNA In Si
    Xiao Jun Ma; Fiscal Year: 2012
    ..Ig) light chain restriction (LCR) detection is an important molecular diagnostic tool in the differential diagnosis that includes lymphoid hyperplasia, atypical lymphoid hyperplasia, chronic inflammation, and B cell ..
  16. Diagnosis of Cervical Precancers Using Raman Spectroscopy
    Anita Mahadevan-Jansen; Fiscal Year: 2012
    ..This proposal seeks to prove the hypothesis that Raman spectroscopy, can provide differential diagnosis of cervical precancers, both high and low grade from inflammation, squamous metaplasia and normal areas of ..
  17. Pathophysiology of Spasmodic Dysphonia: a TMS study
    Teresa Jacobson Kimberley; Fiscal Year: 2013
    ..Long term objecties: Future work may lead to a more definitive differential diagnosis between AdSD and other disorders and the development of innovative evidence-based interventions directly ..
  18. High-specificity, non-invasive methods for monitoring lung transplants
    JOHN FREDERIC BEAUSANG; Fiscal Year: 2013
    ..a signal for acute rejection, an (2) Demonstrate the specificity of donor-specific cell-free DNA for the differential diagnosis of rejection from infection. We have assembled a distinguished team of investigators to lead this project...
  19. Determinants of Neurodegenerative Decline in Primary Progressive Aphasia
    EMILY J ROGALSKI; Fiscal Year: 2013
    ..Therefore, we predict that atrophy rates in language related brain areas will be useful in differential diagnosis and monitoring of disease progression in PPA, potentially pointing the way to an outcome measure for ..
  20. Promoting genetic literacy in students and teachers: The effectiveness of non-cla
    LETA MEOLE TRIBBLE; Fiscal Year: 2010
  21. Proteome Characterization Center: A Genoproteomics Pipeline for Cancer Biomarkers
    Zhen Zhang; Fiscal Year: 2013
    ..molecular route towards the identification of genes and pathways that could be useful for the detection, differential diagnosis, outcome prediction and therapeutic targets of cancer...
  22. Plasma biomarkers for Parkinson's disease
    CATHERINE DANHUA PAN; Fiscal Year: 2011
    ..of PD with other neurodegenerative diseases, especially in their early course, increases the difficulty of differential diagnosis amongst diseases...
  23. Quantitative Mechanical Imaging for Improving Breast Ultrasound Diagnosis
    Timothy J Hall; Fiscal Year: 2013
    ..these three goals represents a significant improvement over current technology, and would likely improve differential diagnosis of breast masses. Preliminary data demonstrate the potential gain from such a device...
  24. Neurocircuitry of Emotion: Distinguishing Late Life Anxiety and Depression
    RUTH M O'HARA; Fiscal Year: 2013
    ..disorders is essential for increasing our understanding of a) the etiology of these disorders;b) their differential diagnosis;c) their relationship to age- related neurodegeneration and cognitive decline;d) vulnerability and ..
  25. Early Social and Emotional Development in Toddlers at Genetic Risk for Autism
    Susan B Campbell; Fiscal Year: 2013
    ..implications for the early identification and treatment of children with autism and will contribute to differential diagnosis of autism, ASD, and language delay as distinct from typical, but uneven development...
    Keith D Paulsen; Fiscal Year: 2010
    ..either alone or in combination, to breast imaging for (a) risk assessment, (b) early detection, (c) differential diagnosis, (d) treatment prognosis and (e) therapy monitoring...
  27. Stanford Mood Disorders Center: Enhancing Core Clinical Research Resources
    Alan F Schatzberg; Fiscal Year: 2010
    ..research involving brain imaging can help understand the biological bases of major depression and aid in differential diagnosis and treatment development...
  28. Functional Brain Networks: A Novel Approach to Address Clinical Challenges in PD
    David Eidelberg; Fiscal Year: 2013
    ..Project 3 aims to establish the feasibility of a new network-based algorithm for providing earlier and more accurate differential diagnosis than is currently possible.
  29. A Controlled Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
    DAVID CHARLES FOSTER; Fiscal Year: 2013
  30. Primary Progressive Aphasia: Cognition, Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2013
    ..Characterization of the linguistic impairments can provide information critical for early differential diagnosis, but speec and language functions are rarely assessed in the setting of dementia clinics...
    Charles Bennett; Fiscal Year: 2000
    ..Among HIV-infected inpatients with pulmonary symptoms, the differential diagnosis includes PCP, CAP, or TB...
  32. Framework for a perceptually-driven taxonomy of dysarthric speech
    ..However, the Mayo Clinic approach to differential diagnosis suffers significant limitations in that 1) there is substantial overlap of perceptual characteristics ..
  33. Functional neuroimaging of language processing in primary progressive aphasia
    Stephen M Wilson; Fiscal Year: 2012
    ..of brain atrophy, and different likelihoods of particular underlying pathogenic processes, making correct differential diagnosis highly relevant...
  34. Amyloid PET in AD, FTLD &PPA: Diagnosis, Functional &Structural Correlations
    GIL DAN RABINOVICI; Fiscal Year: 2012
    ..research is to apply PET imaging with the amyloid-beta (AP) ligand Pittsburgh Compound-B (PIB) towards the differential diagnosis of dementia, while simultaneously studying the relationships between amyloid deposition, clinical ..
  35. Development of a Novel Biomarker for Mucopolysaccharidosis I, II, and VI
    Brett E Crawford; Fiscal Year: 2012
    ..This proposal aims to develop the Sensi-Pro assay further for clinical use for the differential diagnosis and measurement of response to therapy in MPS I, II and VI...
  36. Development of a handheld probe for confocal microscopy and Raman spectroscopy*
    Anita Mahadevan Jansen; Fiscal Year: 2010
    ..confocal Raman instrument with confocal imaging as well as bright-field imaging capability for the differential diagnosis of skin lesions by providing real-time, automated, non-intrusive spectral as well as spatial information ..
  37. Quantitative MRI of Iron Homeostasis, Atrophy and Tissue Structure in AD Brain
    Joseph A Helpern; Fiscal Year: 2011
    ..use in (a) studying the pathogenesis of AD, (b) monitoring disease progression, and (c) aiding in the differential diagnosis of AD...
  38. Proof-of-Concept for Card-Based CD4 Cell Counting
    HAROLD EDWARD AYLIFFE; Fiscal Year: 2010
  39. Viral Arrays for Biodefense
    W Ian Lipkin; Fiscal Year: 2010
    ..assays for public health laboratory, hospital-based clinical laboratory and point-of-care-use to enable differential diagnosis of infection by select NIAID priority agents, agents that may cause signs and symptoms that may mimic ..
  40. Genotype Analysis for Diagnosis of Urea Cycle Disorders
    Steven Dobrowolski; Fiscal Year: 2005
    ..b>Differential diagnosis of individual urea cycle enzyme defects is complex...
  41. Dementia in HIV patients over 60 years of age
    Victor Valcour; Fiscal Year: 2010
    ..While completing this highly relevant research, the candidate will strengthen his clinical skills in the differential diagnosis of cognitive disorders of aging with particular emphasis on potential interactions with HIV and learn the ..
  42. A new serum test for the differential diagnosis of pituitary masses
    Patrizio Caturegli; Fiscal Year: 2010
    ..to discover the pituitary autoantigens and therefore develop an antibody-based serologic test for the differential diagnosis of non-functioning pituitary masses. PUBLIC HEALTH RELEVANCE: Pituitary masses are common...
  43. Empowering Physicians with Evidence-Based Decision Support for Pediatric Rheumato
    Michael M Segal; Fiscal Year: 2012
    ..disease, as well as ~200 conditions not already in the database that are likely to arise in the differential diagnosis. For a subset of 25 diseases this information will be further refined by experts using disease-based, ..
    Julene K Johnson; Fiscal Year: 2010
    ..impairment for possible inclusion in future primary prevention and treatment trials, and 3) expand differential diagnosis with individuals who present with isolated executive impairment to include AD in addition to ..
    Bruce L Miller; Fiscal Year: 2013
    ..While improving differential diagnosis, we hope to further understanding of the puzzling and troubling socio-emotional, executive control, and ..
  46. Articulator Movement in Developmental Apraxia of Speech
    MARIA IRENE GRIGOS; Fiscal Year: 2010
    ..This will have an important impact on the differential diagnosis of DAS, as well as therapeutic intervention...
  47. Dissociating mTBI and PTSD brain activity at rest
    JASON T GRAVANO; Fiscal Year: 2013
    ..findings from this study may eventually lead to the identification of neural risk/resilience factors, identify potential targets of treatment, track changes associated with treatment, and potentially aid in differential diagnosis.
  48. Molecular Classification of Suspicious Thyroid Tumors
    Martha Zeiger; Fiscal Year: 2009
    A. SPECIFIC AIMS Diagnostic Dilemma in the Differential Diagnosis of a Suspicious Thyroid Nodule...
  49. Psycholinguistic Investigations of Development and Disorders of Speech Production
    Edwin Maas; Fiscal Year: 2013
    ..A complete understanding of the nature of these disorders is lacking, complicating differential diagnosis and treatment...
  50. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..A novel PCR assay will be used for differential diagnosis of dengue serotypes and other diseases (Project 3)...
    Cameron S Carter; Fiscal Year: 2013
    ..This need is especially salient in the context of first episode (FE) psychosis, where differential diagnosis is highly challenging and the benefits of targeted early treatments are most pronounced...
  52. Highly Paramagnetic, Biodegradable Nanoclusters for Imaging Prostate Cancer
    Andrew Tsourkas; Fiscal Year: 2013
    ..DNCs will be conjugated to the scFv of antibody F77, which recognizes a unique glycolipid antigen that is specifically expressed on the cell surface of both androgen-dependent and androgen-independent prostate cancer cells. ..
  53. Quantitative, Model-based Medical Decision support by Bayesian Inference
    Gilles Clermont; Fiscal Year: 2010
    ..Such a tool might be of great assistance to clinicians in integrating this dynamic flow of information in the formulation of diagnoses and optimally informed therapeutic strategies. ..
  54. Community Cancer Genetics and Research Training (Revision)
    Jeffrey Weitzel; Fiscal Year: 2009
    ..The curriculum and delivery design may serve as a model for dissemination to other cancer centers to help address NCI priorities such as augmentation of familial registries (e.g. Cooperative Family Studies) ..
  55. Microarray analysis of thyroid neoplasm
    Martha Zeiger; Fiscal Year: 2004
    Although fine needle aspiration (FNA) cytology is the best diagnostic tool in the differential diagnosis of a thyroid nodule, it often cannot differentiate a benign from a malignant lesion...
  56. Co-occurence of Language and Attention Difficulties in Children
    Sean M Redmond; Fiscal Year: 2013
    ..and attention deficits and to advance the translation of behavioral phenotypes of language impairment (LI) into clinical protocols appropriate for differential diagnosis and the identification of cases of LI+ADHD comorbidity and
    John Fink; Fiscal Year: 1999
    ..two genetic loci for HSP, ascertained more than 150 HSP kindreds, and published clinical features and differential diagnosis of this disorder...
  58. A Stochastic Judgment Model of Recall: Separating Measurement, Memory and Correla
    DAVID ERNEST HUBER; Fiscal Year: 2010
    ..These measurement tools will be relevant to differential diagnoses of perceptual disorders as well as clinical therapies designed to alleviate perceptual difficulty. ..
    Andrew Leuchter; Fiscal Year: 1999
    ..This proposal aims to: first, complete validation of QEEG as a method for the differential diagnosis of dementia and depression; second, use QEEG methods to identify indicators of prognosis in dementia and ..
  60. Immersive Virtual Patients with Abnormal Clinical Conditions for Medical Student
    Benjamin Lok; Fiscal Year: 2009
    ..The feedback will focus on the interview, eye-exam, observation of key symptoms, and differential diagnosis. Aim #3 Pilot-test the integration of abnormal findings virtual patients into the education curriculum...
  61. Multiplex Mass Tag PCR for African Viral Hemorrhagic Fevers
    Daniel G Bausch; Fiscal Year: 2010
    ..rapid and sensitive multiplex molecular assays for the VHFs, as well as other diseases included in their differential diagnosis. Features that will enhance the probabilitv of success of this proposal include the availability of ..
  62. Quantitative periprosthetic PET/CT
    Thomas Lang; Fiscal Year: 2009
    ..We believe that a novel metal artifact-corrected PET/CT scan will ensure patient safety by providing a differential diagnosis of both aseptic osteolysis and infection and will help improve surgical planning and avoid misdiagnosis of ..
    James Moe; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): There is a critical unmet need for novel biomarkers for differential diagnosis of Alzheimer's disease (AD) at early onset and to stage disease progression...
    Michael Goldbaum; Fiscal Year: 1992
    ..That description is used by a neural network or an expert system either to create a differential diagnosis list with the probability of each diagnosis or to detect change in a sequence of images...
    HILDEGARD MARICQ; Fiscal Year: 1992
    ..and short medical history to detect risk factors and major disorders, confirmation of RP diagnosis and differential diagnosis with acrocyanosis, and detection of RP subjects at risk for SDS by capillary microscopy...
    Brooke Hallowell; Fiscal Year: 2002
    ..Research: The distinction of competence from performance issues is often problematic in the process of differential diagnosis of communication deficits in neurologically impaired patients...
  67. Development of Platelet & Coagulation Activation Assays
    RONALD SHEBUSKI; Fiscal Year: 2001
    ..Furthermore, differential diagnosis of platelet activation vs...
    Anthony Komaroff; Fiscal Year: 1991
    ..tests will be performed according to an explicit protocol designed to pursue various elements of the differential diagnosis of chronic fatigue...
  69. 18F-AV-133, A Novel Radiopharmaceutical for Differential Diagnosis of Dementia
    Franz Hefti; Fiscal Year: 2009
    ..Brain imaging techniques provide a non-invasive tool for differential diagnosis and monitoring of disease progression of dementia...
  70. Attentional Dysfunction and Recovery in Traumatic Brain Injury (TBI)
    ANDREW ROBERT MAYER; Fiscal Year: 2010
    ..diagnosis, it is likely that they will provide incremental information that will be important for both differential diagnosis and predictions about future outcome...
  71. Identifying acute tubular necrosis in cirrhosis patients with renal dysfunction
    Chirag R Parikh; Fiscal Year: 2010
    ..Making an accurate differential diagnosis between these two entities has important therapeutic and prognostic implications...