blood urea nitrogen

Summary

Summary: The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Top Publications

  1. ncbi Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    FEBS Lett 581:1071-8. 2007
  2. doi Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys
    Seyed Fazel Nabavi
    National elites foundation of Iran, Tehran, Iran
    Biol Trace Elem Res 145:369-74. 2012
  3. ncbi Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats
    Ihab Talat Abdel-Raheem
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Assiut, Egypt
    Biol Pharm Bull 32:61-7. 2009
  4. pmc Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis
    L R Narasimhan
    Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:4617-21. 2001
  5. ncbi The pathological role of Bax in cisplatin nephrotoxicity
    Q Wei
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    Kidney Int 72:53-62. 2007
  6. pmc Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis
    Laura Perin
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9357. 2010
  7. doi Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats
    Min You Qi
    Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, China
    J Ethnopharmacol 138:731-6. 2011
  8. doi L-Carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Nephrol 24:490-8. 2011
  9. ncbi The effect of ginger extract on blood urea nitrogen and creatinine in mice
    Modaresi Mehrdad
    Islamic Azad University, Khorasgan Branch, Isfahan, Iran
    Pak J Biol Sci 10:2968-71. 2007
  10. ncbi Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells
    B Zhang
    Division of Nephrology, Department of Medicine, Penn State Milton S, Hershey Medical Center and College of Medicine, Hershey, Pennsylvania 17033, USA
    Kidney Int 72:37-44. 2007

Detail Information

Publications246 found, 100 shown here

  1. ncbi Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    FEBS Lett 581:1071-8. 2007
    ..At biochemical level, we found that IF causes significant improvement in blood urea nitrogen (BUN), creatinine, albumin and HDL cholesterol, parameters that are associated with the development of DN...
  2. doi Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys
    Seyed Fazel Nabavi
    National elites foundation of Iran, Tehran, Iran
    Biol Trace Elem Res 145:369-74. 2012
    ..Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant...
  3. ncbi Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats
    Ihab Talat Abdel-Raheem
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Assiut, Egypt
    Biol Pharm Bull 32:61-7. 2009
    ..The rats were sacrificed on the seventh day and kidneys were collected for histopathological studies. Blood urea nitrogen (BUN) and creatinine levels were measured in the blood...
  4. pmc Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis
    L R Narasimhan
    Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:4617-21. 2001
    ..We correlated these measurements against simultaneously taken blood samples that were analyzed for blood urea nitrogen (BUN) and creatinine, which are the accepted standards indicating the level of nitrogenous waste loading in ..
  5. ncbi The pathological role of Bax in cisplatin nephrotoxicity
    Q Wei
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    Kidney Int 72:53-62. 2007
    ..Compared with the wild-type mice renal function, as measured by blood urea nitrogen and serum creatinine, was partially but significantly preserved in Bax knockout mice...
  6. pmc Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis
    Laura Perin
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9357. 2010
    ..We therefore speculate that AFSC could represent a novel source of stem cells that may function to modulate the kidney immune milieu in renal failure caused by ATN...
  7. doi Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats
    Min You Qi
    Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, China
    J Ethnopharmacol 138:731-6. 2011
    ..Therefore, the pharmacological studied of its diabetic nephropathy effect was undertaken to validate its traditional use...
  8. doi L-Carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Nephrol 24:490-8. 2011
    ..This study aimed to investigate, on a mechanism basis, whether L-carnitine could prevent the development of IFO-induced Fanconi syndrome in rats...
  9. ncbi The effect of ginger extract on blood urea nitrogen and creatinine in mice
    Modaresi Mehrdad
    Islamic Azad University, Khorasgan Branch, Isfahan, Iran
    Pak J Biol Sci 10:2968-71. 2007
    ..Control group received saline containing equal volume of ethanol. Blood Urea Nitrogen (BUN) and creatinine were measured spectrophotometrically...
  10. ncbi Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells
    B Zhang
    Division of Nephrology, Department of Medicine, Penn State Milton S, Hershey Medical Center and College of Medicine, Hershey, Pennsylvania 17033, USA
    Kidney Int 72:37-44. 2007
    ..Chimeras with kidneys of TNF-alpha knockout mice showed significantly less renal dysfunction (blood urea nitrogen, serum creatinine, and glomerular filtration rate), renal histologic injury, and serum TNF-alpha levels; ..
  11. ncbi Role of p38 mitogen-activated protein kinase on renal dysfunction after hemorrhagic shock in rats
    Hiroaki Sato
    Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Shock 24:488-94. 2005
    ..We concluded that p38 MAPK activation is essential in causing renal damage and that the inhibition of p38 MAPK activation blocks the development of the renal dysfunction after hemorrhagic shock...
  12. ncbi Significance of the fractional excretion of urea in the differential diagnosis of acute renal failure
    Christos P Carvounis
    Department of Medicine, Division of Nephrology, Nassau University Medical Center and State University of New York atStony Brook, East Meadow, New York 11554, USA
    Kidney Int 62:2223-9. 2002
    ..In contrast, the fractional excretion of urea nitrogen (FEUN) is primarily dependent on passive forces and is therefore less influenced by diuretic therapy...
  13. ncbi The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment
    T H Yen
    Histopathology Unit, Cancer Research UK, London Research Institute, London, UK
    Cell Prolif 40:143-56. 2007
    ....
  14. ncbi Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate
    J Lewis
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Kidney Dis 38:744-53. 2001
    ..Formulas using demographic data and readily measured serum values estimate (125)I-iothalamate GFR...
  15. pmc Adverse effect profile of trichlormethiazide: a retrospective observational study
    Yasuo Takahashi
    Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Cardiovasc Diabetol 10:45. 2011
    ..We performed a retrospective cohort study to assess the adverse effects of trichlormethiazide, focusing on serum electrolyte and uric acid levels...
  16. pmc Renal cholesterol accumulation: a durable response after acute and subacute renal insults
    R A Zager
    Department of Medicine, Fred Hutchinson Cancer Center, University of Washington, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Pathol 159:743-52. 2001
    ..Overnight dehydration raised renal CE levels, most notably in the medulla...
  17. ncbi Elevated blood urea nitrogen-to-creatinine ratio increased the risk of hospitalization and all-cause death in patients with chronic heart failure
    Hung Ju Lin
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Res Cardiol 98:487-92. 2009
    To examine the relationship between blood urea nitrogen (BUN)-to-creatinine ratio and the prognosis of chronic heart failure (HF).
  18. ncbi Comparison of prognostic significance of amino-terminal pro-brain natriuretic Peptide versus blood urea nitrogen for predicting events in patients hospitalized for heart failure
    Heather J Shenkman
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 99:1143-5. 2007
    N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and blood urea nitrogen (BUN) predict outcomes in patients with heart failure (HF)...
  19. doi Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity
    Bidya Dhar Sahu
    National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad, India
    Food Chem Toxicol 49:3090-7. 2011
    ..05) increase in serum creatinine, blood urea nitrogen (BUN) and relative weight of kidney with higher kidney MDA (malondialdehyde), tROS (total reactive oxygen ..
  20. doi Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury
    Chengjin Gao
    Department of Burn and Plastic Surgery, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    Burns 35:547-52. 2009
    ..Serum amylase, serum creatinine (Scr) and blood urea nitrogen (BUN) were identified and the kidneys were examined histologically with immunohistochemistry (IHC) as well ..
  21. doi The protective effect of erdosteine on radiocontrast induced nephrotoxicity in rats
    Ahmet Yesilyurt
    Deparment of Medical Genetics, Dr Zekai Tahir Burak Women Health Training and Research Hospital, Ankara Turkey
    Environ Toxicol 26:395-402. 2011
    ..Serum creatinine, BUN (Blood Urea Nitrogen) and cystatin-C levels were measured from serum samples. The kidneys were evaluated histopathologically...
  22. ncbi Massive and disproportionate elevation of blood urea nitrogen in acute azotemia
    Donald A Feinfeld
    Department of Medicine, Nassau University Medical Center, East Meadow, New York 11554, USA
    Int Urol Nephrol 34:143-5. 2002
    In renal failure, blood urea nitrogen and serum creatinine usually rise in tandem; the normal BUN: Cr ratio is 10-15: 1...
  23. doi Reduced hydration status characterized by disproportionate elevation of blood urea nitrogen to serum creatinine among the patients with cerebral infarction
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Jichi Medical School, Shimotsuke, Japan
    Med Hypotheses 77:601-4. 2011
    ..investigated, and their hydration status were evaluated by using several clinical parameters such as a blood urea nitrogen to serum creatinine (BUN/Cr) ratio of >25 and plasma osmolality...
  24. doi Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice
    Yi An
    Department of Cardiology, The Affiliated Hospital of Qingdao University Medical College, China
    Exp Toxicol Pathol 63:215-9. 2011
    ..showed significant protection as evidenced by the decrease of elevated serum creatinine (CRE) and blood urea nitrogen (BUN), and improvement of histopathological injury induced by cisplatin...
  25. ncbi Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats
    V Eybl
    Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarska 48, 301 66 Pilsen, Czech Republic
    Hum Exp Toxicol 27:347-53. 2008
    ..The pretreatment with antioxidants did not affect the increase in renal iron content, blood urea nitrogen/creatinine ratio, and relative kidney weight of FeNTA-intoxicated rats...
  26. doi Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation
    S S Ghosh
    Department of Internal Medicine Nephrology, Sanger Hall, Rm 8 059, Virginia Commonwealth Univ, 1101 E Marshall St, Richmond, VA 23298, USA
    Am J Physiol Renal Physiol 296:F1146-57. 2009
    ..Sham-operated animals served as a control. Renal dysfunction in the Nx group, as evidenced by elevated blood urea nitrogen, plasma creatinine, proteinuria, segmental sclerosis, and tubular dilatation, was significantly reduced by ..
  27. ncbi Resveratrol improves ifosfamide-induced Fanconi syndrome in rats
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Toxicol Appl Pharmacol 222:33-41. 2007
    ..Therefore, its therapeutic role in preventing the development of chemotherapeutic drug-induced major toxicity in the urinary system requires further elucidation...
  28. pmc Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure
    Jeffrey M Testani
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 58:375-82. 2011
    The purpose of this study was to investigate whether a surrogate for renal neurohormonal activation, blood urea nitrogen (BUN), could identify patients destined to experience adverse outcomes associated with the use of high-dose loop ..
  29. ncbi Serum creatinine and blood urea nitrogen over a six-year period in the very old. Creatinine and BUN in the very old
    D A Feinfeld
    Department of Medicine, Nassau County Medical Center, East Meadow, New York, USA
    Geriatr Nephrol Urol 8:131-5. 1998
    ..Use of diuretics and NSAID by functioning elderly individuals is not necessarily associated with worsening azotemia...
  30. doi Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure
    Amir Kazory
    University of Florida, Gainesville, USA
    Am J Cardiol 106:694-700. 2010
    ..The results of several recent HF trials have shed light on the differential role of blood urea nitrogen (BUN) and creatinine in predicting the outcomes in this setting...
  31. ncbi Early changes in blood urea nitrogen predict mortality in acute pancreatitis
    Bechien U Wu
    Brigham and Women s Hospital, Center for Pancreatic Disease, Division of Gastroenterology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 137:129-35. 2009
    ..The objective of this study was to evaluate accuracy of serial blood urea nitrogen (BUN) versus serial hemoglobin (Hgb) measurement for prediction of in-hospital mortality in AP.
  32. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
    ..histopathology remains the gold standard for nephrotoxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary options for monitoring kidney dysfunction in humans...
  33. ncbi Dialysate made from dry chemicals using citric acid increases dialysis dose
    S Ahmad
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 35:493-9. 2000
    ..Using dialysate containing citric instead of acetic acid increases the delivered dialysis dose...
  34. doi Relation of blood urea nitrogen to long-term mortality in patients with heart failure
    Clay A Cauthen
    Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Cardiol 101:1643-7. 2008
    ..Recent studies have demonstrated that blood urea nitrogen (BUN) might serve as a powerful predictor of mortality in acutely decompensated HF...
  35. ncbi Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates
    Ajay J Kirtane
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    J Am Coll Cardiol 45:1781-6. 2005
    We hypothesized that elevated blood urea nitrogen (BUN) would be associated with adverse outcomes independent of serum creatinine (sCr)-based estimates of kidney function in patients with acute coronary syndromes (ACS).
  36. ncbi Has mortality from acute renal failure decreased? A systematic review of the literature
    Yvonne Patricia Ympa
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Am J Med 118:827-32. 2005
    ..To determine mortality rates in patients with acute renal failure during the past decades...
  37. doi The importance of low blood urea nitrogen levels in pregnant patients undergoing hemodialysis to optimize birth weight and gestational age
    Yukari Asamiya
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Japan
    Kidney Int 75:1217-22. 2009
    ..There were significant negative relationships between the blood urea nitrogen (BUN) level and the birth weight or gestational age in the latter cohort...
  38. ncbi Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) study
    Gerasimos Filippatos
    Department of Cardiology, Athens University, Athens, Greece
    J Card Fail 13:360-4. 2007
    ..The association between baseline blood urea nitrogen (BUN) and clinical outcomes in patients admitted for ADHF was evaluated in a post-hoc analysis of the ACTIV ..
  39. ncbi Effects of amrinone on bilateral renal ischemia/reperfusion injury
    R Karabulut
    Department of Pediatric Surgery, Faculty of Medicine, Gazy University, Ankara, Turkey
    Urol Res 30:164-8. 2002
    ..We propose that this preventive effect of amrinone - which has gained clinical application especially in cases of cardiac insufficiency - could also be exploited in clinical conditions related with renal ischemia/reperfusion...
  40. doi The protein equivalent of nitrogen appearance in critically ill acute renal failure patients undergoing continuous renal replacement therapy
    Muthusamy V Ganesan
    Department of Dietetics, Apollo Hospitals, Chennai, India
    J Ren Nutr 19:161-6. 2009
    ..To assess the nutritional status of critically ill patients with acute renal failure on continuous renal replacement therapy (CRRT) and their protein needs by estimating the protein equivalent of nitrogen appearance (PNA)...
  41. ncbi Olprinone reduces ischemia/reperfusion-induced acute renal injury in rats through enhancement of cAMP
    Akio Mizutani
    Division of Intensive Care Unit, Oita University Faculty of Medicine Hospital, Hasama machi, Oita, 879 5593, Japan
    Shock 24:281-7. 2005
    ..Olprinone reduced the I/R-induced increases in serum levels of blood urea nitrogen and creatinine, and improved histological changes, including acute tubular necrosis in the outer medulla...
  42. ncbi Targeting superoxide dismutase to renal proximal tubule cells attenuates vancomycin-induced nephrotoxicity in rats
    Yoshihiro Nishino
    Department of Gastroenterology and Hepato Biliary Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno, Osaka 545 8585, Japan
    Free Radic Res 37:373-9. 2003
    ..VCM induced renal injury dose-dependently. Biochemical analyses revealed that plasma levels of blood urea nitrogen and creatinine significantly increased in the VCM-treated group by an AH-SOD-inhibitable mechanism...
  43. ncbi Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice
    Joshua M Thurman
    Division of Nephrology University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:1517-23. 2003
    ..Our results demonstrate that complement activation in the kidney after I/R occurs exclusively via the alternative pathway, and that selective inhibition of this pathway provides protection to the kidneys from ischemic ARF...
  44. ncbi Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice
    M S Choi
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Republic of Korea
    Diabetes Metab Res Rev 24:74-81. 2008
    ..This study investigated the beneficial effects of genistein and daidzein on IDDM, an autoimmune disease...
  45. ncbi Novel evidence suggesting an anti-oxidant property for erythropoietin on vancomycin-induced nephrotoxicity in a rat model
    Hasan Cetin
    Department of Pediatrics, Medical Faculty, Suleyman Demirel University, Isparta, Turkey
    Clin Exp Pharmacol Physiol 34:1181-5. 2007
    ..On Day 8, renal tissues were excised and blood samples were collected. Serum creatinine and blood urea nitrogen were measured, along with renal malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) ..
  46. pmc Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury
    Jae Il Lee
    Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Korea
    J Vet Sci 7:79-81. 2006
    ..The purpose of this study was to investigate the influence of ascorbic acid on blood urea nitrogen (BUN), creatinine (Cr) and resistive index (RI) for dog models with renal ischemia-reperfusion (I/R) injury...
  47. ncbi Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2
    Akanksha Gupta
    Division of Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0444, USA
    Am J Physiol Renal Physiol 293:F245-54. 2007
    ..treatment exhibited ARF as illustrated by markedly reduced peritubular capillary flow and increased serum blood urea nitrogen (BUN) levels...
  48. ncbi The effects of sevoflurane on serum creatinine and blood urea nitrogen concentrations: a retrospective, twenty-two-center, comparative evaluation of renal function in adult surgical patients
    R I Mazze
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 90:683-8. 2000
    ..The trials examined postoperative changes in serum creatinine and blood urea nitrogen levels from a total of 3, 436 ASA physical status I-IV adult surgical patients administered either ..
  49. ncbi Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
    Liping Wu
    Dept of Pharmacology and Toxicology, Univ of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 292:F261-8. 2007
    ..8951, P < 0.0001). These data show that peritubular capillary dysfunction is an early event that contributes to tubular stress and renal injury...
  50. ncbi Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Med 116:466-73. 2004
    ..In heart failure, renal function involves both cardiovascular and hemodynamic properties. We studied the relation between renal dysfunction and mortality in patients admitted for decompensated heart failure...
  51. ncbi Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab 160 062, India
    FEBS Lett 581:2027-35. 2007
    ..5mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin...
  52. ncbi 6-Gingerol prevents cisplatin-induced acute renal failure in rats
    Anurag Kuhad
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Biofactors 26:189-200. 2006
    ..6-Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6-gingerol on cisplatin-induced oxidative stress and renal dysfunction...
  53. ncbi Effects of pre- and post-ischemic treatments with FK409, a nitric oxide donor, on ischemia/reperfusion-induced renal injury and endothelin-1 production in rats
    Atsushi Nakajima
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Biol Pharm Bull 29:577-9. 2006
    ....
  54. ncbi Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad, 34668 Istanbul, Turkey
    Prostaglandins Other Lipid Mediat 83:257-67. 2007
    ..for 4 weeks. At the end of the 4 weeks, rats were decapitated and trunk blood was collected. Creatinine, blood urea nitrogen and lactate dehydrogenase (LDH) activity were measured in the serum samples, while leukotriene B(4), TNF-..
  55. ncbi Biochemical and histopathological findings of N-butyl-2-cyanoacrylate in oral surgery: an experimental study
    Samet Inal
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e14-7. 2006
    ..The objective of the present study was to investigate possible immediate and long-term systemic effects of N-butyl-2-cyanoacrylate in oral surgery...
  56. ncbi Role of nitric oxide in resveratrol-induced renal protective effects of ischemic preconditioning
    Vikas Chander
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    J Vasc Surg 42:1198-205. 2005
    ..This study was designed to explore the involvement of NO in the renoprotective effect of resveratrol in renal ischemic preconditioning in rat kidney...
  57. ncbi Ginkgo biloba extract ameliorates ischemia reperfusion-induced renal injury in rats
    Goksel Sener
    Department of Pharmacology, School of Pharmacy, Marmara University, Tibbiye Cad, 34668 Istanbul, Turkey
    Pharmacol Res 52:216-22. 2005
    ..The findings imply that ROMs play a causal role in I/R-induced renal injury and EGb exerts renoprotective effects probably by the radical scavenging and antioxidant activities...
  58. ncbi [Effect of inorganic nitrates on the morphofunctional condition of the kidney in the rat]
    Abdelwahab Zaki
    Laboratoire de Physiologie Animale, Faculte des Sciences et Techniques, Beni Mellal, Maroc
    Therapie 60:75-9. 2005
    ..The aim of our experimental study was to determine the effect of exogenic nitrates on certain biological parameters in relation to renal insufficiency...
  59. ncbi Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide
    Samira Saleh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 97:91-7. 2005
    ..of cisplatin injection, acute nephrotoxicity was demonstrated by a marked increase in serum creatinine and blood urea nitrogen. Histological examination of the kidneys confirmed the occurrence of renal damage...
  60. ncbi The nephroprotective effects of the herbal medicine preparation, WH30+, on the chemical-induced acute and chronic renal failure in rats
    Heidi H Y Ngai
    Division of Food and Nutritional Sciences, Department of Zoology The University of Hong Kong, Hong Kong SAR, P R China
    Am J Chin Med 33:491-500. 2005
    ..05) greater creatinine clearance than those without treatment. The results of the study show that WH30+ is more effective in the prevention of acute renal failure than chronic renal failure...
  61. ncbi Parachlorophenylalanine exacerbates oxidative stress induced by gentamicin in rats
    Juan R Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Cordoba, Spain
    Basic Clin Pharmacol Toxicol 97:174-8. 2005
    ..Catalase and superoxide dismutase activities were determined in brain tissue. Blood urea nitrogen and creatinine in plasma and total protein content in urine were also measured...
  62. ncbi Combination of exercise and enalapril enhances renoprotective and peripheral effects in rats with renal ablation
    Masayuki Kanazawa
    Department of Internal Medicine and Rehabilitation Science, Center for Preventive Medicine and Well Being, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Am J Hypertens 19:80-6. 2006
    ..Therefore, we assessed the renal and peripheral effects of moderate to intense EX as well as the effects of the combination of EX and enalapril (ENA) in a rat model of CRF...
  63. ncbi Investigating the protective effects of aged garlic extract on cyclosporin-induced nephrotoxicity in rats
    Orawan Wongmekiat
    Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Fundam Clin Pharmacol 19:555-62. 2005
    ..b>Blood urea nitrogen, serum creatinine, creatinine clearance, and renal histopathological changes were evaluated after 24 h of ..
  64. pmc Shiga toxin 1 causes direct renal injury in rats
    Elise T Yamamoto
    Department of Clinical Pharmacology, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Infect Immun 73:7099-106. 2005
    ..right kidneys were removed after the Stx1 perfusion of the left kidneys, the serum creatinine and blood urea nitrogen levels were increased from day 2, and acute renal failure followed on day 3...
  65. ncbi The effects of mibefradil, a T-type Ca2+ channels blocker, on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney
    Ayten Gezici
    Department of Nuclear Medicine, Medical School, Dicle University, Diyarbakir, Turkey
    Ren Fail 27:775-81. 2005
    ..Serum creatinine, blood urea nitrogen (BUN), kidney malondialdehyde (MDA) level were determined as well as examining the kidneys histologically...
  66. ncbi Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity
    M Sarwar Alam
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India
    Food Chem Toxicol 45:910-20. 2007
    ..of 4 mg/kg body weight HgCl(2) induced renal injury evident as a marked elevation in serum creatinine and blood urea nitrogen levels, and histopathological changes such as necrosis, oedema and congestion of stroma and glomeruli...
  67. ncbi The effect of alpha-melanocyte stimulating hormone on gentamicin-induced acute nephrotoxicity in rats
    Meltem Kolgazi
    Department of Physiology, Marmara University, School of Medicine, 34668 Haydarpasa, Istanbul, Turkey
    J Appl Toxicol 27:183-8. 2007
    ..Trunk blood and 24 h urine were collected to measure the serum creatinine levels, blood urea nitrogen (BUN) levels and to calculate the creatinine clearance values...
  68. ncbi Protective effects of N-acetylcysteine on cyclosporine-A-induced nephrotoxicity
    Mehmet Duru
    Mustafa Kemal University Medical Faculty, Hatay, Turkey
    Ren Fail 30:453-9. 2008
    ..We assessed the protective ability of N-acetylcysteine (NAC), an antioxidant, against CsA-induced nephrotoxicity...
  69. doi Studies on the protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney
    Shubha Priyamvada
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U P, India
    Prostaglandins Leukot Essent Fatty Acids 78:369-81. 2008
    ..GM nephrotoxicity was recorded by increased serum creatinine and blood urea nitrogen. GM increased the activities of lactate and glucose-6-phosphate dehydrogenases whereas decreased malate, ..
  70. ncbi [Study of the Shenshuaining dispersible tablets in treating chronic renal failure rats induced by adenine]
    Yun Ma
    Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Zhong Yao Cai 30:432-5. 2007
    ..To observe the effect of Shenshuaining dispersible tablets in treating chronic renal failure (CRF) rats...
  71. ncbi Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats
    Cristino Cruz
    Departamento de Nefrologia y Metabolismo Mineral, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico
    Am J Physiol Renal Physiol 293:F1691-8. 2007
    ..2 ml/kg ip) every other day for 30 days. Proteinuria and serum creatinine and blood urea nitrogen concentrations were measured on days 0, 5, 10, 15, and 30, and systolic blood pressure was recorded on days ..
  72. ncbi Chinese herbal formula Qilong-Lishui granule improves puromycin aminonucleoside-induced renal injury through regulation of bone morphogenetic proteins
    Ping Li
    Department of Pharmacology, Institute of Clinical Medical Science, China Japan Friendship Hospital, Beijing, China
    Nephrology (Carlton) 12:466-73. 2007
    ..However, molecular and cellular mechanisms of QLG are still unclear. Therefore, the objective of the current study is to investigate molecular and cellular mechanisms of QLG in puromycin aminonucleoside (PAN)-induced nephrotic syndrome...
  73. ncbi Exaggerated renal pathology of partial ablation-induced chronic renal failure in eNOS deficient mice
    Chika Yamashita
    Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Biol Pharm Bull 31:1029-31. 2008
    ..There were significant increments of blood urea nitrogen level, plasma creatinine concentration and proteinuria in both wild-type and eNOS-/- mice at 8 weeks after ..
  74. ncbi Preconditioning with oxygen attenuates rat renal ischemia-reperfusion injury
    Bahram Rasoulian
    Research Center for Trauma, Baqiyatallah University of Medical Sciences, Tehran, Iran
    J Surg Res 146:282-8. 2008
    ..The purpose of this study was to investigate the effects of pre-exposure to hyperoxic environment on rat renal IR injury for the first time...
  75. ncbi The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
    Ahmed O Abdel-Zaher
    Department of Pharmacolog, Faculty of Medicine, Assiut University, Assiut, Egypt
    Toxicology 243:261-70. 2008
    ..These results provide evidence that inhibition of NO overproduction and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of alpha-LA against APAP-induced hepatic and renal damage...
  76. ncbi Oral sorbent AST-120 increases renal NO synthesis in uremic rats
    Zohra Tumur
    Department of Clinical Preventive Medicine, Nagoya University Hospital, Nagoya, Japan
    J Ren Nutr 18:60-4. 2008
    ..We determined whether the administration of an oral sorbent, AST-120, increases the urine level of NOx and the renal expression of nitric oxide synthase (NOS) isoforms in CRF rats...
  77. ncbi Vitamin C attenuates cisplatin-induced alterations in renal brush border membrane enzymes and phosphate transport
    Sabiha Fatima
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002 UP, India
    Hum Exp Toxicol 26:419-26. 2007
    ..These results suggest that vitamin C is an effective chemoprotectant against cisplatin-induced acute renal failure and dysfunction of the renal BBM in rats...
  78. ncbi Protective effect of captopril against cisplatin-induced nephrotoxicity in rats
    El Sayed M El-Sayed
    Pharmacology and Toxicology Department, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Pak J Pharm Sci 21:255-61. 2008
    ..A single dose of cisplatin (7.5 mg/kg bwt) injected i.p. caused a significant increase in blood urea nitrogen (BUN) and creatinine levels amounting to 402% and 573%, respectively with a marked elevation in lipid ..
  79. ncbi Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats
    Li Lin Liu
    Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China
    Toxicology 231:81-90. 2007
    ..with DXR alone caused significant changes in the levels of urinary protein, serum creatinine (SCr), and blood urea nitrogen (BUN). Co-administration with amlodipine effectively reversed the effect of DXR on these parameters...
  80. ncbi Stobadine protects rat kidney against ischaemia/reperfusion injury
    Galip Guz
    Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey
    Clin Exp Pharmacol Physiol 34:210-6. 2007
    ..Immediately thereafter, blood was drawn and tissue samples were harvested to assess: (i) serum levels of blood urea nitrogen and creatinine; (ii) serum and/or tissue levels of malondialdehyde (MDA), glutathione (GSH), glucose 6-..
  81. ncbi Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure
    Kazufumi Iwata
    Department of Pharmacy, Kumamoto University Hospital, 1 1 1 Honjo, Kumamoto, Japan
    Pharm Res 24:662-71. 2007
    ..The purpose of the present study was to explore the involvement of indoxyl sulfate (IS) in nephrotoxicity and central nervous system (CNS) toxicity in cisplatin (CDDP)-treated rats...
  82. ncbi Pharmacokinetics and hepatic extraction of metoprolol in rats with glycerol-induced acute renal failure
    Hiroko Tanabe
    Graduate School of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 30:552-5. 2007
    ..These results suggested that the decreased CL/F of metoprolol in rats with glycerol-induced ARF is mainly a result of the increased initial absorption rate in the intestine followed by partial saturation of hepatic first-pass metabolism...
  83. ncbi [Experimental study of chronic kidney failure delayed by Xinshen capsule]
    Lu Yu
    The Peoples Liberation Army 305 Hospital, Beijing 100017, China
    Zhongguo Zhong Yao Za Zhi 31:2058-61. 2006
    ..To evaluate the effect of Xinshen capsule upon the chronic kidney disease progress by the study of 7/8 kidney removal rat model...
  84. ncbi Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria
    N A G Santos
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Av do Cafe S N, 14040 903, Ribeirao Preto, SP, Brazil
    Cancer Chemother Pharmacol 61:145-55. 2008
    ..cisplatin-induced effects were prevented by DMTU: (1) increased plasmatic levels of creatinine and blood urea nitrogen (BUN); (2) decreased ATP content, calcium uptake and electrochemical potential; (3) oxidation of lipids, ..
  85. doi Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide
    Hui Chen
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China
    J Surg Res 149:287-95. 2008
    ..The objective of this study was to examine the hypothesis that protective effects of OzoneOP in renal I/R injury were associated with endogenous NO...
  86. ncbi Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
    ..3. Gentamicin resulted in a significant increase in serum creatinine, blood urea nitrogen (BUN), thiobarbituric acid-reactive substances (TBARS) and total nitrate/nitrite (NOx) and a significant ..
  87. ncbi Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity
    T A Ajith
    Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala 680 555, India
    Food Chem Toxicol 46:3178-81. 2008
    ..001) in the Z. officinale (400mg/kg) plus DXN treated group. The nephroprotection is mediated by preventing the DXN-induced decline of renal antioxidant status, and also by increasing the activity of GST...
  88. doi Poly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide
    Arda Tasatargil
    Department of Pharmacology, Akdeniz University Medical Faculty, Antalya, Turkey
    Ren Fail 30:115-20. 2008
    ..Endotoxemia was induced by LPS injection (10 mg/kg, i.v.). LPS increased blood urea nitrogen (BUN) levels from 22 +/- 0.54 mg/dL to 45.7 +/- 5.79 mg/dL (p < 0.05)...
  89. ncbi Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy
    Naoko Tazawa
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    J Cardiovasc Pharmacol 44:S467-70. 2004
    ..rats exhibited earlier and higher increases in systolic blood pressure, urinary protein excretion, blood urea nitrogen and plasma creatinine concentration, compared with cases in wild-type rats...
  90. ncbi (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors
    Takako Yokozawa
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharm Pharmacol 56:231-9. 2004
    ....
  91. ncbi Cisplatin-induced acute renal failure is ameliorated by erdosteine in a dose-dependent manner
    Huseyin Ozyurt
    Gaziosmanpasa University School of Medicine, Department of Biochemistry, Tokat, Turkey
    J Appl Toxicol 24:269-75. 2004
    ..led to acute renal failure, as indicated by kidney histology and increases in plasma creatinine and blood urea nitrogen (BUN) levels. At 5 days after cisplatin injection the BUN level was increased significantly from 15.1 +/- 4...
  92. ncbi The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats
    Devinder Singh
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Pharmacol Res 50:187-93. 2004
    ..Serum creatinine and blood urea nitrogen (BUN) concentrations were measured for the evaluation of renal function...
  93. ncbi Renal toxicity of a nondopaminergic antipsychotic agent, trimethyl imidazopyrazolopyrimidine, in rats
    G E Macallum
    Parke Davis Research Institute, Warner Lambert Canada Inc, Mississauga, Ontario
    Toxicol Pathol 22:39-47. 1994
    ..No renal toxicity was noted with the acid hydrolysis products. The urothelial changes with oral administration of TIPP in rats is species-specific, and the specificity may be related to the metabolism and excretion of the drug...
  94. ncbi An oral adsorbent ameliorates renal overload of indoxyl sulfate and progression of renal failure in diabetic rats
    I Aoyama
    Nagoya University Daiko Medical Center, Nagoya, Japan
    Am J Kidney Dis 37:S7-S12. 2001
    ..In conclusion, AST-120 delayed the progression of renal failure and fibrosis in 1/2NxOLETF rats and decreased the overload of indoxyl sulfate on renal tubular cells...
  95. ncbi Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 17:146-53. 2003
    ..These findings suggest that lipid peroxidation is not the main cause of CP-induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules...
  96. ncbi L-carnitine ameliorates oxidative damage due to chronic renal failure in rats
    Goksel Sener
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    J Cardiovasc Pharmacol 43:698-705. 2004
    ..These results suggest that L-carnitine supplementation may have some benefit in CRF patients...
  97. ncbi Selective angiotensin II type 1 receptor blockade ameliorates cyclosporine nephrotoxicity
    Satyanarayana S V Padi
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Pharmacol Res 45:413-20. 2002
    ..Renal function was assessed by estimating serum creatinine, blood urea nitrogen (BUN), creatinine and urea clearance...
  98. ncbi Amelioration by beraprost sodium, a prostacyclin analogue, of established renal dysfunction in rat glomerulonephritis model
    Masateru Yamada
    Pharmaceutical Research Laboratories, Toray Industries, Inc, 1111 Tebiro Kamakura, Kanagawa 248 8555, Japan
    Eur J Pharmacol 449:167-76. 2002
    ..Beraprost sodium treatment inhibited the increase in urinary protein, serum creatinine and blood urea nitrogen, and the decrease in creatinine clearance...
  99. pmc Comparison between carvedilol and captopril in rats with partial ablation-induced chronic renal failure
    D P Brooks
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pa 19406 0939
    Br J Pharmacol 109:581-6. 1993
    ..These data indicate that the rats probably had 24 h systemic exposure to carvedilol.6. The present study indicates that carvedilol is effective in attenuating the progression of chronic renal failure in rats...
  100. ncbi Nucleotides modulate renal ischaemia-reperfusion injury by different effects on nitric oxide and superoxide
    J Lopez-Marti
    Department of Medical Bioanalysis, Instituto de Investigaciones Biomédicas de Barcelona, Spain
    Clin Exp Pharmacol Physiol 30:242-8. 2003
    ....
  101. ncbi Oxidative stress-mediated renal dysfunction by cyclosporine A in rats: attenuation by trimetazidine
    Padi S V Satyanarayana
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh, India
    Ren Fail 24:259-74. 2002
    ..These results clearly demonstrate the pivotal role of reactive oxygen species and their relation to renal dysfunction and point to the therapeutic potential of an anti-ischemic agent, trimetazidine, in CsA-induced nephrotoxicity...

Research Grants99

  1. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Singh; Fiscal Year: 2009
    ..on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  2. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Singh; Fiscal Year: 2009
    ..on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  3. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  4. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  5. Associations between Non-8-Carbon-Chain Perfuoroalkyl Acids and Serum Lipid, Live
    Stephanie J Frisbee; Fiscal Year: 2010
    ..Direct Bilirubin BiliTotal Total Bilirubin GGT Gamma glutamyltransferase LDH Lactate dehydrogenase BUN Blood urea nitrogen PUBLIC HEALTH RELEVANCE: NARRATIVE The primary objective of this proposal is to determine the associations ..
  6. Role of apolipoprotein M in acute kidney injury
    Didier Portilla; Fiscal Year: 2009
    ..We find also increased shedding of urinary ApoM that precedes changes in blood urea nitrogen and serum creatinine in wild type mice as well as human ApoM transgenic mice exposed to cisplatin...
  7. Development of a Urea Biosensor Using the UreR Protein
    HARRY MOBLEY; Fiscal Year: 2004
    ..The blood urea nitrogen (BUN) test, a routine but critical clinical laboratory assay used to evaluate renal function, quantifies ..
  8. Development of a Urea Biosensor Using the UreR Protein
    HARRY MOBLEY; Fiscal Year: 2003
    ..The blood urea nitrogen (BUN) test, a routine but critical clinical laboratory assay used to evaluate renal function, quantifies ..
  9. ANTAGONISTS FOR CIS-PLATINUM NEPHROTOXICITY
    Mark Jones; Fiscal Year: 1990
    ..function in experimental animals (rats) will be monitored (via measurement of serum creatinine levels and blood urea nitrogen values) as the animals are taken through various protocols designed to allow the administration of cis-..
  10. RENAL CRYOPRESERVATION
    RICHARD LILLEHEI; Fiscal Year: 1980
    ..Serum levels of blood urea nitrogen and creatinine are determined daily after contralateral nephrectomy in the dogs...
  11. CHLOROANILINE-INDUCED NEPHROTOXICITY
    GARY RANKIN; Fiscal Year: 1990
    ..content, pH, osmolality), in vitro accumulation of organic ions by renal cortical slices, kidney weight, blood urea nitrogen (BUN) concentration and histology (light and electron microscopy)...
  12. Multi-slice Perfusion MR Imaging of the Human Kidney
    H Gach; Fiscal Year: 2004
    ..Bioassays of serum creatinine, blood urea nitrogen (BUN), and urine output may indicate the occurrence of renal dysfunction but not the type...
  13. Multi-slice Perfusion MR Imaging of the Human Kidney
    H Gach; Fiscal Year: 2003
    ..Bioassays of serum creatinine, blood urea nitrogen (BUN), and urine output may indicate the occurrence of renal dysfunction but not the type...
  14. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2000
    ..and enzymuria), (b) blood analysis (serum tumor necrosis factor-alpha, interleukin-1 and interleukin-6 vs blood urea nitrogen), (c) histology (localization of 4-hydroxynonenal- and malondialdehyde-adducts vs histopathology), (d) ..
  15. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 1999
    ..and enzymuria), (b) blood analysis (serum tumor necrosis factor-alpha, interleukin-1 and interleukin-6 vs blood urea nitrogen), (c) histology (localization of 4-hydroxynonenal- and malondialdehyde-adducts vs histopathology), (d) ..
  16. DYSPHAGIA THERAPY FOLLOWING STROKE--CONTROLLED TRIAL
    Michael Reding; Fiscal Year: 1990
    ..Dependent variables will assess the following: state of hydration (serum electrolytes, blood urea nitrogen (BUN), BUN to creatinine ratio, and urine specific gravity); calorie-nitrogen balance (body weight, serum ..
  17. CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve
    Sudhir V Shah; Fiscal Year: 2010
    ..Patients with kidney disease have higher levels of blood urea nitrogen, which can be transformed into products that modify proteins by a process known as carbamylation...
  18. FETAL NUTRITION VIA THE GASTROINTESTINAL TRACT
    Valerie Charlton; Fiscal Year: 1980
    ..provision of substrates on fetal umbilical uptake of nutrients, oxygen consumption, acid-base balance, blood urea nitrogen and ammonia concentrations...
  19. Breath Ammonia Measurements for Dialysis Assessment
    C Patel; Fiscal Year: 2001
    ..We show correlations with reductions in blood urea nitrogen (BUN: approximately 90mg/dL to approximately 30mg/dL) and creatinine (approximately 14mg/dL to ..
  20. B-2 Microglobulin:Renal Biomarker Workplace U Exposure
    Susan Pinney; Fiscal Year: 2003
    ..the relationship between beta-2-microglobulin and other parameters of renal function (serum creatinine, blood urea nitrogen, urinary protein, blood and glucose in urine) and compare those relationships in workers to the unexposed ..
  21. Nanoliter Lab-on-a-Chip for Blood Diagnostics
    Michael Pollack; Fiscal Year: 2004
    ..Colorimetric assays of four important and common analytes (blood urea nitrogen, creatinine, glucose, and lactate) in human blood serum will be demonstrated establishing just feasibility ..
  22. B-2 Microglobulin:Renal Biomarker Workplace U Exposure
    Susan Pinney; Fiscal Year: 2004
    ..the relationship between beta-2-microglobulin and other parameters of renal function (serum creatinine, blood urea nitrogen, urinary protein, blood and glucose in urine) and compare those relationships in workers to the unexposed ..
  23. CONVENTIONAL VS HIGH PROTEIN INTAKE RATE TO ELBW NEONATE
    Patti Thureen; Fiscal Year: 2001
    ..Safety will be assessed by plasma amino acid and blood urea nitrogen concentrations...
  24. CONVENTIONAL VS HIGH PROTEIN INTAKE RATE TO ELBW NEONATE
    Patti Thureen; Fiscal Year: 2002
    ..Safety will be assessed by plasma amino acid and blood urea nitrogen concentrations...
  25. MECHANISMS OF VANCOMYCIN-INDUCED NEPHROTOXICITY
    Mary Smith; Fiscal Year: 1993
    ..These changes include elevations in blood urea nitrogen (BUN) concentrations, decreased gluconeogenic capacity and decreased ability to accumulate organic ions...
  26. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2007
    ..each of 11 routinely available acute physiology measures (blood pressure, heart rate, temperature, glucose, blood urea nitrogen, creatinine, sodium, potassium, billirubin, hematocrit and white blood count) and death in 2,250 critically ..
  27. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2005
    ..each of 11 routinely available acute physiology measures (blood pressure, heart rate, temperature, glucose, blood urea nitrogen, creatinine, sodium, potassium, billirubin, hematocrit and white blood count) and death in 2,250 critically ..
  28. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2009
    ..each of 11 routinely available acute physiology measures (blood pressure, heart rate, temperature, glucose, blood urea nitrogen, creatinine, sodium, potassium, billirubin, hematocrit and white blood count) and death in 2,250 critically ..
  29. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2006
    ..each of 11 routinely available acute physiology measures (blood pressure, heart rate, temperature, glucose, blood urea nitrogen, creatinine, sodium, potassium, billirubin, hematocrit and white blood count) and death in 2,250 critically ..
  30. MINORITY BIOMEDICAL SUPPORT
    JOSEPH WUTOH; Fiscal Year: 1980
    ..methoxyflurane, will have their hematology and clinical chemistry values determined (hemoglobin, glucose, Blood urea nitrogen, hematocrit, creatinine, mean corpuscular volume, alkaline, phosphotase, hemoglobin, red and white blood ..
  31. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter W Nathanielsz; Fiscal Year: 2012
    ..Innovation: Our preliminary data show that 30% MNR produces F NR (decreased F blood urea nitrogen, amino acids and growth factors)...
  32. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter Nathanielsz; Fiscal Year: 2009
    ..Innovation: Our preliminary data show that 30% MNR produces F NR (decreased F blood urea nitrogen, amino acids and growth factors)...
  33. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter Nathanielsz; Fiscal Year: 2007
    ..Innovation: Our preliminary data show that 30% MNR produces F NR (decreased F blood urea nitrogen, amino acids and growth factors)...
  34. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter W Nathanielsz; Fiscal Year: 2010
    ..Innovation: Our preliminary data show that 30% MNR produces F NR (decreased F blood urea nitrogen, amino acids and growth factors)...
  35. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  36. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2005
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  37. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  38. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2008
    ....
  39. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  40. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2006
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  41. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2004
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  42. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 1999
    ....
  43. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  44. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2000
    ....
  45. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 1999
    ....
  46. MECHANISMS IN MYOGLOBINURIC ACUTE RENAL FAILURE
    RICHARD ZAGER; Fiscal Year: 1993
    ..By addressing the above, new insights into heme protein/low molecular weight protein nephrotoxicity and shock-induced renal damage will be obtained which should have direct relevance to crush syndrome induced ARF...
  47. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2000
    ....
  48. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  49. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 1999
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  50. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  51. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  52. MULTICENTER TRIAL OF SYNSORB PK IN E COLI
    Howard Trachtman; Fiscal Year: 1999
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  53. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2005
    ..We believe the proposed work will allow a more complete understanding of the causes of renal function decline and lead to the development of public health interventions to prevent this considerable public health problem. ..
  54. Angiotensin Metabolite Formation by Podocytes: Implications in Glomerular Injury
    JUAN CARLOS VELEZ; Fiscal Year: 2008
    ..Better understanding of the mechanisms of in the kidney should lead to therapies that can directly target. These therapies would improve both quality and length of life of affected individuals. ..
  55. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2003
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  56. Genetic and Environmental Determinants of Warfarin Response
    Nita Limdi; Fiscal Year: 2009
    ..This knowledge will provide an evidence base for future pre-prescription genotyping for accurate warfarin dosing and facilitate its use in qualifying patients. ..
  57. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2000
    ....
  58. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  59. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  60. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2008
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  61. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George Schwartz; Fiscal Year: 2007
    ..These studies should show how hensin and associated proteins mediate the kidney's adaptation to acid-base disturbances. [unreadable] [unreadable]..
  62. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2006
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  63. Genetic and Environmental Determinants of Warfarin Response
    Nita Limdi; Fiscal Year: 2009
    ..This knowledge will provide an evidence base for future pre-prescription genotyping for accurate warfarin dosing and facilitate its use in qualifying patients. ..
  64. Genetic and Environmental Determinants of Warfarin Response
    Nita Limdi; Fiscal Year: 2009
    ..This knowledge will provide an evidence base for future pre-prescription genotyping for accurate warfarin dosing and facilitate its use in qualifying patients. ..
  65. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George Schwartz; Fiscal Year: 2001
    ..The objective is to better understand the role of membrane carbonic anhydrases (CAs) in mediating renal acid-base transport. ..
  66. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  67. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George Schwartz; Fiscal Year: 2002
    ..The objective is to better understand the role of membrane carbonic anhydrases (CAs) in mediating renal acid-base transport. ..
  68. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  69. EPIDEMIOLOGY OF DIABETIC RETINOPATHY
    Ronald Klein; Fiscal Year: 2008
    ..abstract_text> ..
  70. Central Biochemistry Laboratory of the CKiD Consortium
    George Schwartz; Fiscal Year: 2008
    ..The long term goal is to provide accurate assays to characterize the CKiD population and maintain recruitment and retention of CKiD subjects. ..
  71. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2000
    ....
  72. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2004
    ..We believe the proposed work will allow a more complete understanding of the causes of renal function decline and lead to the development of public health interventions to prevent this considerable public health problem. ..
  73. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2004
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  74. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2005
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  75. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2001
    ....
  76. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2006
    ..We believe the proposed work will allow a more complete understanding of the causes of renal function decline and lead to the development of public health interventions to prevent this considerable public health problem. ..
  77. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2001
    ....
  78. EPIDEMIOLOGY OF DIABETIC RETINOPATHY
    Ronald Klein; Fiscal Year: 2006
    ..abstract_text> ..
  79. Autologous Cellular Therapy for Ventricular Dysfunction
    Robert Kormos; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  80. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George Schwartz; Fiscal Year: 2000
    ..The objective is to better understand the role of membrane carbonic anhydrases (CAs) in mediating renal acid-base transport. ..
  81. Mechanisms for Adverse Renal Effects from Lead Exposure
    Virginia Weaver; Fiscal Year: 2006
    ..The proposed work will inform research on specific treatments for high-risk populations, such as those with chronic renal insufficiency who also have increased lead body burdens. [unreadable] [unreadable] [unreadable]..
  82. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2001
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  83. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2002
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  84. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2004
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  85. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2004
    ....
  86. Pharmacogenetic Optimization of Anticoagulation Therapy
    Nita Limdi; Fiscal Year: 2007
    ..With the award of the K23 grant, structured training, guidance of mentors, environment and institutional support provided by the University, I will develop the skills necessary for a productive career in pharmacogenetics research. ..
  87. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2002
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  88. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....