blood urea nitrogen

Summary

Summary: The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Top Publications

  1. ncbi Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    FEBS Lett 581:1071-8. 2007
  2. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
  3. ncbi The pathological role of Bax in cisplatin nephrotoxicity
    Q Wei
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    Kidney Int 72:53-62. 2007
  4. ncbi Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 17:146-53. 2003
  5. ncbi Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys
    Seyed Fazel Nabavi
    National elites foundation of Iran, Tehran, Iran
    Biol Trace Elem Res 145:369-74. 2012
  6. ncbi Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats
    V Eybl
    Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarska 48, 301 66 Pilsen, Czech Republic
    Hum Exp Toxicol 27:347-53. 2008
  7. ncbi Comparison of prognostic significance of amino-terminal pro-brain natriuretic Peptide versus blood urea nitrogen for predicting events in patients hospitalized for heart failure
    Heather J Shenkman
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 99:1143-5. 2007
  8. ncbi Prevention of nephrotoxicity of cisplatin by repeated oral administration of ebselen in rats
    M Yoshida
    Department of Chemistry, St Marianna University School of Medicine, Kawasaki, Japan
    Tohoku J Exp Med 191:209-20. 2000
  9. ncbi Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity
    Bidya Dhar Sahu
    National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad, India
    Food Chem Toxicol 49:3090-7. 2011
  10. ncbi Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats
    Min You Qi
    Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, China
    J Ethnopharmacol 138:731-6. 2011

Detail Information

Publications261 found, 100 shown here

  1. ncbi Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    FEBS Lett 581:1071-8. 2007
    ..At biochemical level, we found that IF causes significant improvement in blood urea nitrogen (BUN), creatinine, albumin and HDL cholesterol, parameters that are associated with the development of DN...
  2. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
    ..histopathology remains the gold standard for nephrotoxicity in animal systems, serum creatinine (SCr) and blood urea nitrogen (BUN) are the primary options for monitoring kidney dysfunction in humans...
  3. ncbi The pathological role of Bax in cisplatin nephrotoxicity
    Q Wei
    Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Augusta, Georgia 30912, USA
    Kidney Int 72:53-62. 2007
    ..Compared with the wild-type mice renal function, as measured by blood urea nitrogen and serum creatinine, was partially but significantly preserved in Bax knockout mice...
  4. ncbi Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 17:146-53. 2003
    ..These findings suggest that lipid peroxidation is not the main cause of CP-induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules...
  5. ncbi Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys
    Seyed Fazel Nabavi
    National elites foundation of Iran, Tehran, Iran
    Biol Trace Elem Res 145:369-74. 2012
    ..Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant...
  6. ncbi Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats
    V Eybl
    Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Medicine in Pilsen, Karlovarska 48, 301 66 Pilsen, Czech Republic
    Hum Exp Toxicol 27:347-53. 2008
    ..The pretreatment with antioxidants did not affect the increase in renal iron content, blood urea nitrogen/creatinine ratio, and relative kidney weight of FeNTA-intoxicated rats...
  7. ncbi Comparison of prognostic significance of amino-terminal pro-brain natriuretic Peptide versus blood urea nitrogen for predicting events in patients hospitalized for heart failure
    Heather J Shenkman
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 99:1143-5. 2007
    N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and blood urea nitrogen (BUN) predict outcomes in patients with heart failure (HF)...
  8. ncbi Prevention of nephrotoxicity of cisplatin by repeated oral administration of ebselen in rats
    M Yoshida
    Department of Chemistry, St Marianna University School of Medicine, Kawasaki, Japan
    Tohoku J Exp Med 191:209-20. 2000
    ..Treatment with CDDP alone resulted in significantly increased plasma creatinine (Cr) and blood urea nitrogen (BUN) levels. Repeated administration of 5.5 and 11...
  9. ncbi Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity
    Bidya Dhar Sahu
    National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad, India
    Food Chem Toxicol 49:3090-7. 2011
    ..05) increase in serum creatinine, blood urea nitrogen (BUN) and relative weight of kidney with higher kidney MDA (malondialdehyde), tROS (total reactive oxygen ..
  10. ncbi Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats
    Min You Qi
    Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, China
    J Ethnopharmacol 138:731-6. 2011
    ..Therefore, the pharmacological studied of its diabetic nephropathy effect was undertaken to validate its traditional use...
  11. ncbi The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage
    Ahmed O Abdel-Zaher
    Department of Pharmacolog, Faculty of Medicine, Assiut University, Assiut, Egypt
    Toxicology 243:261-70. 2008
    ..These results provide evidence that inhibition of NO overproduction and maintenance of intracellular antioxidant status may play a pivotal role in the protective effects of alpha-LA against APAP-induced hepatic and renal damage...
  12. ncbi Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells
    B Zhang
    Division of Nephrology, Department of Medicine, Penn State Milton S, Hershey Medical Center and College of Medicine, Hershey, Pennsylvania 17033, USA
    Kidney Int 72:37-44. 2007
    ..Chimeras with kidneys of TNF-alpha knockout mice showed significantly less renal dysfunction (blood urea nitrogen, serum creatinine, and glomerular filtration rate), renal histologic injury, and serum TNF-alpha levels; ..
  13. ncbi The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment
    T H Yen
    Histopathology Unit, Cancer Research UK, London Research Institute, London, UK
    Cell Prolif 40:143-56. 2007
    ....
  14. pmc Adverse effect profile of trichlormethiazide: a retrospective observational study
    Yasuo Takahashi
    Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Cardiovasc Diabetol 10:45. 2011
    ..We performed a retrospective cohort study to assess the adverse effects of trichlormethiazide, focusing on serum electrolyte and uric acid levels...
  15. ncbi Potentiation of mercury-induced nephrotoxicity by endotoxin in the Sprague-Dawley rat
    W K Rumbeiha
    Department of Veterinary Pathology, G303 Veterinary Medical Center, Michigan State University, East Lansing, MI 48824 1314, USA
    Toxicology 149:75-87. 2000
    ..05). In conclusion, LPS potentiated mercury-induced nephrotoxicity...
  16. ncbi Blood urea nitrogen concentration as a marker of amino-acid intolerance in neonates with birthweight less than 1250 g
    Erick Ridout
    Section of Neonatology, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Perinatol 25:130-3. 2005
    Currently blood urea nitrogen (BUN) is commonly used as a marker of protein intolerance in very preterm infants...
  17. ncbi Solute clearances and fluid removal in the frequent hemodialysis network trials
    Tom Greene
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Am J Kidney Dis 53:835-44. 2009
    ..The goal of this study was to project separation between the treatment and control arms of these studies for measures of dialysis dose by using simulations based on 2-compartment variable-volume models...
  18. ncbi The effect of ginger extract on blood urea nitrogen and creatinine in mice
    Modaresi Mehrdad
    Islamic Azad University, Khorasgan Branch, Isfahan, Iran
    Pak J Biol Sci 10:2968-71. 2007
    ..Control group received saline containing equal volume of ethanol. Blood Urea Nitrogen (BUN) and creatinine were measured spectrophotometrically...
  19. ncbi Elevated blood urea nitrogen is an independent risk factor of prolonged intensive care unit stay due to acute necrotizing pancreatitis
    Maik Faisst
    Department of General and Visceral Surgery, University of Freiburg, Freiburg, Germany
    J Crit Care 25:105-11. 2010
    The aim of this study was to analyze the predictive value of blood urea nitrogen (BUN) and other variables in acute necrotizing pancreatitis on hospital stay, intensive care unit (ICU) stay, and death.
  20. ncbi The ratio of the blood urea nitrogen/creatinine index in patients with acute renal failure is decreased due to dextran or mannitol
    Tsuyoshi Kouki
    Department of Endocrinology and Metabolism, University of the Ryukyus School of Medicine, Nishihara
    Intern Med 49:223-6. 2010
    ..Both showed decreases in the blood urea nitrogen (BUN)/creatinine ratios after the administration of these reagents...
  21. ncbi Blood urea nitrogen and creatinine levels at admission for mortality risk assessment in patients with acute coronary syndromes
    Ruslan T Saygitov
    City Clinical Hospital N 59, Moscow, Russian Federation
    Emerg Med J 27:105-9. 2010
    To compare the prognostic significance of blood urea nitrogen (BUN) versus creatinine levels for estimating the risk of death in patients with acute coronary syndrome (ACS).
  22. ncbi Japanese Black breeding herd exhibiting low blood urea nitrogen: a metabolic profile study examining the effect on reproductive performance
    Urara Watanabe
    United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
    Anim Sci J 84:389-94. 2013
    Ten reared cows of a Japanese Black cattle herd in Kagoshima prefecture, Japan, exhibited extremely low blood urea nitrogen (BUN) concentration (2.6 ± 0.6 mg/dL)...
  23. ncbi Ginkgo biloba extract protects against mercury(II)-induced oxidative tissue damage in rats
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Food Chem Toxicol 45:543-50. 2007
    ..On the other hand, EGb treatment reversed all these biochemical indices. Our results implicate that mercury-induced oxidative damage in brain, lung, liver, and kidney tissues protected by G. biloba extract, with its antioxidant effects...
  24. ncbi Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity
    M Sarwar Alam
    Department of Chemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110 062, India
    Food Chem Toxicol 45:910-20. 2007
    ..of 4 mg/kg body weight HgCl(2) induced renal injury evident as a marked elevation in serum creatinine and blood urea nitrogen levels, and histopathological changes such as necrosis, oedema and congestion of stroma and glomeruli...
  25. ncbi Using blood urea nitrogen to predict nitrogen excretion and efficiency of nitrogen utilization in cattle, sheep, goats, horses, pigs, and rats
    R A Kohn
    Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA
    J Anim Sci 83:879-89. 2005
    ..Blood urea N can be used in various animal species to quantify N utilization and excretion rates...
  26. ncbi A revised day +7 predictive score for transplant-related mortality: serum cholinesterase, total protein, blood urea nitrogen, gamma glutamyl transferase, donor type and cell dose
    M P Sormani
    Unitá Epidemiologia Clinica, Istituto Scientifio Tumori, Genoa, Italy
    Bone Marrow Transplant 32:205-11. 2003
    ..a scoring system for patients undergoing hemopoietic stem cell transplantation (HSCT) based on day +7 blood urea nitrogen (BUN) and serum bilirubin levels...
  27. ncbi Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats
    H Kudo
    Department of Clinical Medicine, Bunkyo Gakuin University, Tokyo, Japan
    Toxicology 246:143-7. 2008
    ..Activities of lactate dehydrogenase and alkaline phosphatase were decreased, and the concentrations of blood urea nitrogen and creatinine were increased with the reduction in plasma calcium and inorganic phosphorus levels, i.e...
  28. ncbi Elevated blood urea nitrogen-to-creatinine ratio increased the risk of hospitalization and all-cause death in patients with chronic heart failure
    Hung Ju Lin
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Res Cardiol 98:487-92. 2009
    To examine the relationship between blood urea nitrogen (BUN)-to-creatinine ratio and the prognosis of chronic heart failure (HF).
  29. ncbi Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation
    S S Ghosh
    Department of Internal Medicine Nephrology, Sanger Hall, Rm 8 059, Virginia Commonwealth Univ, 1101 E Marshall St, Richmond, VA 23298, USA
    Am J Physiol Renal Physiol 296:F1146-57. 2009
    ..Sham-operated animals served as a control. Renal dysfunction in the Nx group, as evidenced by elevated blood urea nitrogen, plasma creatinine, proteinuria, segmental sclerosis, and tubular dilatation, was significantly reduced by ..
  30. ncbi The protective effect of erdosteine on radiocontrast induced nephrotoxicity in rats
    Ahmet Yesilyurt
    Deparment of Medical Genetics, Dr Zekai Tahir Burak Women Health Training and Research Hospital, Ankara Turkey
    Environ Toxicol 26:395-402. 2011
    ..Serum creatinine, BUN (Blood Urea Nitrogen) and cystatin-C levels were measured from serum samples. The kidneys were evaluated histopathologically...
  31. ncbi Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury
    Chengjin Gao
    Department of Burn and Plastic Surgery, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    Burns 35:547-52. 2009
    ..Serum amylase, serum creatinine (Scr) and blood urea nitrogen (BUN) were identified and the kidneys were examined histologically with immunohistochemistry (IHC) as well ..
  32. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
    ..In conclusion, hyperuricemia has a pathogenic role in the mild tubulointerstitial injury associated with diabetic nephropathy but not glomerular damage in db/db mice. Lowering uric acid may reduce tubulointerstitial injury in diabetes...
  33. pmc Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis
    L R Narasimhan
    Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:4617-21. 2001
    ..We correlated these measurements against simultaneously taken blood samples that were analyzed for blood urea nitrogen (BUN) and creatinine, which are the accepted standards indicating the level of nitrogenous waste loading in ..
  34. pmc Comparative effect of olmesartan and candesartan on lipid metabolism and renal function in patients with hypertension: a retrospective observational study
    Yayoi Nishida
    Division of Genomic Epidemiology and Clinical Trials, Advanced Medical Research Center, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Cardiovasc Diabetol 10:74. 2011
    ..We performed a retrospective observational study to compare the effects of olmesartan with those of candesartan, focusing on lipid metabolism and renal function...
  35. ncbi Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice
    M S Choi
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702 701, Republic of Korea
    Diabetes Metab Res Rev 24:74-81. 2008
    ..This study investigated the beneficial effects of genistein and daidzein on IDDM, an autoimmune disease...
  36. ncbi Novel evidence suggesting an anti-oxidant property for erythropoietin on vancomycin-induced nephrotoxicity in a rat model
    Hasan Cetin
    Department of Pediatrics, Medical Faculty, Suleyman Demirel University, Isparta, Turkey
    Clin Exp Pharmacol Physiol 34:1181-5. 2007
    ..On Day 8, renal tissues were excised and blood samples were collected. Serum creatinine and blood urea nitrogen were measured, along with renal malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) ..
  37. ncbi The effects of sevoflurane on serum creatinine and blood urea nitrogen concentrations: a retrospective, twenty-two-center, comparative evaluation of renal function in adult surgical patients
    R I Mazze
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 90:683-8. 2000
    ..The trials examined postoperative changes in serum creatinine and blood urea nitrogen levels from a total of 3, 436 ASA physical status I-IV adult surgical patients administered either ..
  38. ncbi Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats
    Cristino Cruz
    Departamento de Nefrologia y Metabolismo Mineral, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico
    Am J Physiol Renal Physiol 293:F1691-8. 2007
    ..2 ml/kg ip) every other day for 30 days. Proteinuria and serum creatinine and blood urea nitrogen concentrations were measured on days 0, 5, 10, 15, and 30, and systolic blood pressure was recorded on days ..
  39. ncbi L-Carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Nephrol 24:490-8. 2011
    ..This study aimed to investigate, on a mechanism basis, whether L-carnitine could prevent the development of IFO-induced Fanconi syndrome in rats...
  40. ncbi Role of p38 mitogen-activated protein kinase on renal dysfunction after hemorrhagic shock in rats
    Hiroaki Sato
    Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Shock 24:488-94. 2005
    ..We concluded that p38 MAPK activation is essential in causing renal damage and that the inhibition of p38 MAPK activation blocks the development of the renal dysfunction after hemorrhagic shock...
  41. ncbi Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate
    J Lewis
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Kidney Dis 38:744-53. 2001
    ..Formulas using demographic data and readily measured serum values estimate (125)I-iothalamate GFR...
  42. ncbi Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
    Kulbhushan Tikoo
    Laboratory of Chromatin Biology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab 160 062, India
    FEBS Lett 581:2027-35. 2007
    ..5mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin...
  43. ncbi Resveratrol improves ifosfamide-induced Fanconi syndrome in rats
    Ozer Sehirli
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad 34668 Istanbul, Turkey
    Toxicol Appl Pharmacol 222:33-41. 2007
    ..Therefore, its therapeutic role in preventing the development of chemotherapeutic drug-induced major toxicity in the urinary system requires further elucidation...
  44. ncbi Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats
    Ihab Talat Abdel-Raheem
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Assiut, Egypt
    Biol Pharm Bull 32:61-7. 2009
    ..The rats were sacrificed on the seventh day and kidneys were collected for histopathological studies. Blood urea nitrogen (BUN) and creatinine levels were measured in the blood...
  45. ncbi Significance of the fractional excretion of urea in the differential diagnosis of acute renal failure
    Christos P Carvounis
    Department of Medicine, Division of Nephrology, Nassau University Medical Center and State University of New York atStony Brook, East Meadow, New York 11554, USA
    Kidney Int 62:2223-9. 2002
    ..In contrast, the fractional excretion of urea nitrogen (FEUN) is primarily dependent on passive forces and is therefore less influenced by diuretic therapy...
  46. pmc Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure
    Jeffrey M Testani
    Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 58:375-82. 2011
    The purpose of this study was to investigate whether a surrogate for renal neurohormonal activation, blood urea nitrogen (BUN), could identify patients destined to experience adverse outcomes associated with the use of high-dose loop ..
  47. ncbi Serum creatinine and blood urea nitrogen over a six-year period in the very old. Creatinine and BUN in the very old
    D A Feinfeld
    Department of Medicine, Nassau County Medical Center, East Meadow, New York, USA
    Geriatr Nephrol Urol 8:131-5. 1998
    ..Use of diuretics and NSAID by functioning elderly individuals is not necessarily associated with worsening azotemia...
  48. ncbi Early changes in blood urea nitrogen predict mortality in acute pancreatitis
    Bechien U Wu
    Brigham and Women s Hospital, Center for Pancreatic Disease, Division of Gastroenterology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 137:129-35. 2009
    ..The objective of this study was to evaluate accuracy of serial blood urea nitrogen (BUN) versus serial hemoglobin (Hgb) measurement for prediction of in-hospital mortality in AP.
  49. ncbi Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure
    Amir Kazory
    University of Florida, Gainesville, USA
    Am J Cardiol 106:694-700. 2010
    ..The results of several recent HF trials have shed light on the differential role of blood urea nitrogen (BUN) and creatinine in predicting the outcomes in this setting...
  50. ncbi Relation of blood urea nitrogen to long-term mortality in patients with heart failure
    Clay A Cauthen
    Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Cardiol 101:1643-7. 2008
    ..Recent studies have demonstrated that blood urea nitrogen (BUN) might serve as a powerful predictor of mortality in acutely decompensated HF...
  51. ncbi Dialysate made from dry chemicals using citric acid increases dialysis dose
    S Ahmad
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA, USA
    Am J Kidney Dis 35:493-9. 2000
    ..Using dialysate containing citric instead of acetic acid increases the delivered dialysis dose...
  52. ncbi Olprinone reduces ischemia/reperfusion-induced acute renal injury in rats through enhancement of cAMP
    Akio Mizutani
    Division of Intensive Care Unit, Oita University Faculty of Medicine Hospital, Hasama machi, Oita, 879 5593, Japan
    Shock 24:281-7. 2005
    ..Olprinone reduced the I/R-induced increases in serum levels of blood urea nitrogen and creatinine, and improved histological changes, including acute tubular necrosis in the outer medulla...
  53. ncbi Has mortality from acute renal failure decreased? A systematic review of the literature
    Yvonne Patricia Ympa
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Am J Med 118:827-32. 2005
    ..To determine mortality rates in patients with acute renal failure during the past decades...
  54. ncbi Effects of amrinone on bilateral renal ischemia/reperfusion injury
    R Karabulut
    Department of Pediatric Surgery, Faculty of Medicine, Gazy University, Ankara, Turkey
    Urol Res 30:164-8. 2002
    ..We propose that this preventive effect of amrinone - which has gained clinical application especially in cases of cardiac insufficiency - could also be exploited in clinical conditions related with renal ischemia/reperfusion...
  55. ncbi Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) study
    Gerasimos Filippatos
    Department of Cardiology, Athens University, Athens, Greece
    J Card Fail 13:360-4. 2007
    ..The association between baseline blood urea nitrogen (BUN) and clinical outcomes in patients admitted for ADHF was evaluated in a post-hoc analysis of the ACTIV ..
  56. ncbi Targeting superoxide dismutase to renal proximal tubule cells attenuates vancomycin-induced nephrotoxicity in rats
    Yoshihiro Nishino
    Department of Gastroenterology and Hepato Biliary Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno, Osaka 545 8585, Japan
    Free Radic Res 37:373-9. 2003
    ..VCM induced renal injury dose-dependently. Biochemical analyses revealed that plasma levels of blood urea nitrogen and creatinine significantly increased in the VCM-treated group by an AH-SOD-inhibitable mechanism...
  57. ncbi The importance of low blood urea nitrogen levels in pregnant patients undergoing hemodialysis to optimize birth weight and gestational age
    Yukari Asamiya
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Japan
    Kidney Int 75:1217-22. 2009
    ..There were significant negative relationships between the blood urea nitrogen (BUN) level and the birth weight or gestational age in the latter cohort...
  58. pmc Renal cholesterol accumulation: a durable response after acute and subacute renal insults
    R A Zager
    Department of Medicine, Fred Hutchinson Cancer Center, University of Washington, 1100 Fairview Ave N, Rm D2 190, Seattle, WA 98109, USA
    Am J Pathol 159:743-52. 2001
    ..Overnight dehydration raised renal CE levels, most notably in the medulla...
  59. ncbi Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice
    Yi An
    Department of Cardiology, The Affiliated Hospital of Qingdao University Medical College, China
    Exp Toxicol Pathol 63:215-9. 2011
    ..showed significant protection as evidenced by the decrease of elevated serum creatinine (CRE) and blood urea nitrogen (BUN), and improvement of histopathological injury induced by cisplatin...
  60. ncbi The protein equivalent of nitrogen appearance in critically ill acute renal failure patients undergoing continuous renal replacement therapy
    Muthusamy V Ganesan
    Department of Dietetics, Apollo Hospitals, Chennai, India
    J Ren Nutr 19:161-6. 2009
    ..To assess the nutritional status of critically ill patients with acute renal failure on continuous renal replacement therapy (CRRT) and their protein needs by estimating the protein equivalent of nitrogen appearance (PNA)...
  61. pmc Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis
    Laura Perin
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9357. 2010
    ..We therefore speculate that AFSC could represent a novel source of stem cells that may function to modulate the kidney immune milieu in renal failure caused by ATN...
  62. ncbi Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates
    Ajay J Kirtane
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    J Am Coll Cardiol 45:1781-6. 2005
    We hypothesized that elevated blood urea nitrogen (BUN) would be associated with adverse outcomes independent of serum creatinine (sCr)-based estimates of kidney function in patients with acute coronary syndromes (ACS).
  63. ncbi Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice
    Joshua M Thurman
    Division of Nephrology University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:1517-23. 2003
    ..Our results demonstrate that complement activation in the kidney after I/R occurs exclusively via the alternative pathway, and that selective inhibition of this pathway provides protection to the kidneys from ischemic ARF...
  64. ncbi Reduced hydration status characterized by disproportionate elevation of blood urea nitrogen to serum creatinine among the patients with cerebral infarction
    Tetsu Akimoto
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Jichi Medical School, Shimotsuke, Japan
    Med Hypotheses 77:601-4. 2011
    ..investigated, and their hydration status were evaluated by using several clinical parameters such as a blood urea nitrogen to serum creatinine (BUN/Cr) ratio of >25 and plasma osmolality...
  65. ncbi Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats
    Ozer Sehirli
    School of Pharmacy, Department of Pharmacology, Marmara University, Istanbul, Turkey
    Clin Exp Pharmacol Physiol 35:249-55. 2008
    ..At the end of 24 h, rats were decapitated and trunk blood was collected. Creatinine, blood urea nitrogen (BUN) and lactate dehydrogenase (LDH) activity were measured in serum samples, whereas tumour necrosis ..
  66. ncbi Massive and disproportionate elevation of blood urea nitrogen in acute azotemia
    Donald A Feinfeld
    Department of Medicine, Nassau University Medical Center, East Meadow, New York 11554, USA
    Int Urol Nephrol 34:143-5. 2002
    In renal failure, blood urea nitrogen and serum creatinine usually rise in tandem; the normal BUN: Cr ratio is 10-15: 1...
  67. pmc Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury
    Jae Il Lee
    Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Korea
    J Vet Sci 7:79-81. 2006
    ..The purpose of this study was to investigate the influence of ascorbic acid on blood urea nitrogen (BUN), creatinine (Cr) and resistive index (RI) for dog models with renal ischemia-reperfusion (I/R) injury...
  68. ncbi Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2
    Akanksha Gupta
    Division of Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0444, USA
    Am J Physiol Renal Physiol 293:F245-54. 2007
    ..treatment exhibited ARF as illustrated by markedly reduced peritubular capillary flow and increased serum blood urea nitrogen (BUN) levels...
  69. ncbi Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
    Liping Wu
    Dept of Pharmacology and Toxicology, Univ of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 292:F261-8. 2007
    ..8951, P < 0.0001). These data show that peritubular capillary dysfunction is an early event that contributes to tubular stress and renal injury...
  70. ncbi Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Med 116:466-73. 2004
    ..In heart failure, renal function involves both cardiovascular and hemodynamic properties. We studied the relation between renal dysfunction and mortality in patients admitted for decompensated heart failure...
  71. ncbi Biochemical and histopathological findings of N-butyl-2-cyanoacrylate in oral surgery: an experimental study
    Samet Inal
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e14-7. 2006
    ..The objective of the present study was to investigate possible immediate and long-term systemic effects of N-butyl-2-cyanoacrylate in oral surgery...
  72. ncbi Protective effect of captopril against cisplatin-induced nephrotoxicity in rats
    El Sayed M El-Sayed
    Pharmacology and Toxicology Department, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Pak J Pharm Sci 21:255-61. 2008
    ..A single dose of cisplatin (7.5 mg/kg bwt) injected i.p. caused a significant increase in blood urea nitrogen (BUN) and creatinine levels amounting to 402% and 573%, respectively with a marked elevation in lipid ..
  73. ncbi 6-Gingerol prevents cisplatin-induced acute renal failure in rats
    Anurag Kuhad
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Biofactors 26:189-200. 2006
    ..6-Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6-gingerol on cisplatin-induced oxidative stress and renal dysfunction...
  74. ncbi Combination of exercise and enalapril enhances renoprotective and peripheral effects in rats with renal ablation
    Masayuki Kanazawa
    Department of Internal Medicine and Rehabilitation Science, Center for Preventive Medicine and Well Being, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Am J Hypertens 19:80-6. 2006
    ..Therefore, we assessed the renal and peripheral effects of moderate to intense EX as well as the effects of the combination of EX and enalapril (ENA) in a rat model of CRF...
  75. pmc Shiga toxin 1 causes direct renal injury in rats
    Elise T Yamamoto
    Department of Clinical Pharmacology, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Infect Immun 73:7099-106. 2005
    ..right kidneys were removed after the Stx1 perfusion of the left kidneys, the serum creatinine and blood urea nitrogen levels were increased from day 2, and acute renal failure followed on day 3...
  76. ncbi The nephroprotective effects of the herbal medicine preparation, WH30+, on the chemical-induced acute and chronic renal failure in rats
    Heidi H Y Ngai
    Division of Food and Nutritional Sciences, Department of Zoology The University of Hong Kong, Hong Kong SAR, P R China
    Am J Chin Med 33:491-500. 2005
    ..05) greater creatinine clearance than those without treatment. The results of the study show that WH30+ is more effective in the prevention of acute renal failure than chronic renal failure...
  77. ncbi Role of nitric oxide in resveratrol-induced renal protective effects of ischemic preconditioning
    Vikas Chander
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    J Vasc Surg 42:1198-205. 2005
    ..This study was designed to explore the involvement of NO in the renoprotective effect of resveratrol in renal ischemic preconditioning in rat kidney...
  78. ncbi The effects of mibefradil, a T-type Ca2+ channels blocker, on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney
    Ayten Gezici
    Department of Nuclear Medicine, Medical School, Dicle University, Diyarbakir, Turkey
    Ren Fail 27:775-81. 2005
    ..Serum creatinine, blood urea nitrogen (BUN), kidney malondialdehyde (MDA) level were determined as well as examining the kidneys histologically...
  79. ncbi Parachlorophenylalanine exacerbates oxidative stress induced by gentamicin in rats
    Juan R Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Cordoba, Spain
    Basic Clin Pharmacol Toxicol 97:174-8. 2005
    ..Catalase and superoxide dismutase activities were determined in brain tissue. Blood urea nitrogen and creatinine in plasma and total protein content in urine were also measured...
  80. ncbi Investigating the protective effects of aged garlic extract on cyclosporin-induced nephrotoxicity in rats
    Orawan Wongmekiat
    Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Fundam Clin Pharmacol 19:555-62. 2005
    ..b>Blood urea nitrogen, serum creatinine, creatinine clearance, and renal histopathological changes were evaluated after 24 h of ..
  81. ncbi Effects of pre- and post-ischemic treatments with FK409, a nitric oxide donor, on ischemia/reperfusion-induced renal injury and endothelin-1 production in rats
    Atsushi Nakajima
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Biol Pharm Bull 29:577-9. 2006
    ....
  82. ncbi The effect of alpha-melanocyte stimulating hormone on gentamicin-induced acute nephrotoxicity in rats
    Meltem Kolgazi
    Department of Physiology, Marmara University, School of Medicine, 34668 Haydarpasa, Istanbul, Turkey
    J Appl Toxicol 27:183-8. 2007
    ..Trunk blood and 24 h urine were collected to measure the serum creatinine levels, blood urea nitrogen (BUN) levels and to calculate the creatinine clearance values...
  83. ncbi Chinese herbal formula Qilong-Lishui granule improves puromycin aminonucleoside-induced renal injury through regulation of bone morphogenetic proteins
    Ping Li
    Department of Pharmacology, Institute of Clinical Medical Science, China Japan Friendship Hospital, Beijing, China
    Nephrology (Carlton) 12:466-73. 2007
    ..However, molecular and cellular mechanisms of QLG are still unclear. Therefore, the objective of the current study is to investigate molecular and cellular mechanisms of QLG in puromycin aminonucleoside (PAN)-induced nephrotic syndrome...
  84. ncbi Preconditioning with oxygen attenuates rat renal ischemia-reperfusion injury
    Bahram Rasoulian
    Research Center for Trauma, Baqiyatallah University of Medical Sciences, Tehran, Iran
    J Surg Res 146:282-8. 2008
    ..The purpose of this study was to investigate the effects of pre-exposure to hyperoxic environment on rat renal IR injury for the first time...
  85. ncbi Oral sorbent AST-120 increases renal NO synthesis in uremic rats
    Zohra Tumur
    Department of Clinical Preventive Medicine, Nagoya University Hospital, Nagoya, Japan
    J Ren Nutr 18:60-4. 2008
    ..We determined whether the administration of an oral sorbent, AST-120, increases the urine level of NOx and the renal expression of nitric oxide synthase (NOS) isoforms in CRF rats...
  86. ncbi Poly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide
    Arda Tasatargil
    Department of Pharmacology, Akdeniz University Medical Faculty, Antalya, Turkey
    Ren Fail 30:115-20. 2008
    ..Endotoxemia was induced by LPS injection (10 mg/kg, i.v.). LPS increased blood urea nitrogen (BUN) levels from 22 +/- 0.54 mg/dL to 45.7 +/- 5.79 mg/dL (p < 0.05)...
  87. ncbi Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide
    Hui Chen
    Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China
    J Surg Res 149:287-95. 2008
    ..The objective of this study was to examine the hypothesis that protective effects of OzoneOP in renal I/R injury were associated with endogenous NO...
  88. ncbi Exaggerated renal pathology of partial ablation-induced chronic renal failure in eNOS deficient mice
    Chika Yamashita
    Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Biol Pharm Bull 31:1029-31. 2008
    ..There were significant increments of blood urea nitrogen level, plasma creatinine concentration and proteinuria in both wild-type and eNOS-/- mice at 8 weeks after ..
  89. ncbi Studies on the protective effect of dietary fish oil on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney
    Shubha Priyamvada
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U P, India
    Prostaglandins Leukot Essent Fatty Acids 78:369-81. 2008
    ..GM nephrotoxicity was recorded by increased serum creatinine and blood urea nitrogen. GM increased the activities of lactate and glucose-6-phosphate dehydrogenases whereas decreased malate, ..
  90. ncbi Protective effects of N-acetylcysteine on cyclosporine-A-induced nephrotoxicity
    Mehmet Duru
    Mustafa Kemal University Medical Faculty, Hatay, Turkey
    Ren Fail 30:453-9. 2008
    ..We assessed the protective ability of N-acetylcysteine (NAC), an antioxidant, against CsA-induced nephrotoxicity...
  91. ncbi [Study of the Shenshuaining dispersible tablets in treating chronic renal failure rats induced by adenine]
    Yun Ma
    Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Zhong Yao Cai 30:432-5. 2007
    ..To observe the effect of Shenshuaining dispersible tablets in treating chronic renal failure (CRF) rats...
  92. ncbi Vitamin C attenuates cisplatin-induced alterations in renal brush border membrane enzymes and phosphate transport
    Sabiha Fatima
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002 UP, India
    Hum Exp Toxicol 26:419-26. 2007
    ..These results suggest that vitamin C is an effective chemoprotectant against cisplatin-induced acute renal failure and dysfunction of the renal BBM in rats...
  93. ncbi Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats
    Li Lin Liu
    Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China
    Toxicology 231:81-90. 2007
    ..with DXR alone caused significant changes in the levels of urinary protein, serum creatinine (SCr), and blood urea nitrogen (BUN). Co-administration with amlodipine effectively reversed the effect of DXR on these parameters...
  94. ncbi Stobadine protects rat kidney against ischaemia/reperfusion injury
    Galip Guz
    Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey
    Clin Exp Pharmacol Physiol 34:210-6. 2007
    ..Immediately thereafter, blood was drawn and tissue samples were harvested to assess: (i) serum levels of blood urea nitrogen and creatinine; (ii) serum and/or tissue levels of malondialdehyde (MDA), glutathione (GSH), glucose 6-..
  95. ncbi Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure
    Kazufumi Iwata
    Department of Pharmacy, Kumamoto University Hospital, 1 1 1 Honjo, Kumamoto, Japan
    Pharm Res 24:662-71. 2007
    ..The purpose of the present study was to explore the involvement of indoxyl sulfate (IS) in nephrotoxicity and central nervous system (CNS) toxicity in cisplatin (CDDP)-treated rats...
  96. ncbi Pharmacokinetics and hepatic extraction of metoprolol in rats with glycerol-induced acute renal failure
    Hiroko Tanabe
    Graduate School of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 30:552-5. 2007
    ..These results suggested that the decreased CL/F of metoprolol in rats with glycerol-induced ARF is mainly a result of the increased initial absorption rate in the intestine followed by partial saturation of hepatic first-pass metabolism...
  97. ncbi [Experimental study of chronic kidney failure delayed by Xinshen capsule]
    Lu Yu
    The Peoples Liberation Army 305 Hospital, Beijing 100017, China
    Zhongguo Zhong Yao Za Zhi 31:2058-61. 2006
    ..To evaluate the effect of Xinshen capsule upon the chronic kidney disease progress by the study of 7/8 kidney removal rat model...
  98. ncbi Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria
    N A G Santos
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Av do Cafe S N, 14040 903, Ribeirao Preto, SP, Brazil
    Cancer Chemother Pharmacol 61:145-55. 2008
    ..cisplatin-induced effects were prevented by DMTU: (1) increased plasmatic levels of creatinine and blood urea nitrogen (BUN); (2) decreased ATP content, calcium uptake and electrochemical potential; (3) oxidation of lipids, ..
  99. ncbi Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
    ..3. Gentamicin resulted in a significant increase in serum creatinine, blood urea nitrogen (BUN), thiobarbituric acid-reactive substances (TBARS) and total nitrate/nitrite (NOx) and a significant ..
  100. ncbi Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast
    Goksel Sener
    Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad, 34668 Istanbul, Turkey
    Prostaglandins Other Lipid Mediat 83:257-67. 2007
    ..for 4 weeks. At the end of the 4 weeks, rats were decapitated and trunk blood was collected. Creatinine, blood urea nitrogen and lactate dehydrogenase (LDH) activity were measured in the serum samples, while leukotriene B(4), TNF-..
  101. ncbi Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity
    T A Ajith
    Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala 680 555, India
    Food Chem Toxicol 46:3178-81. 2008
    ..001) in the Z. officinale (400mg/kg) plus DXN treated group. The nephroprotection is mediated by preventing the DXN-induced decline of renal antioxidant status, and also by increasing the activity of GST...

Research Grants66

  1. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    ..on this spontaneous model of lupus will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
  2. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..Using data from this same cohort, we will calculate the accuracy of 5 single markers (glucose, hematocrit, blood urea nitrogen, creatinine, and C-reactive protein) and 7 scoring systems (Ranson's, acute physiology and chronic ..
  3. Role of apolipoprotein M in acute kidney injury
    Didier Portilla; Fiscal Year: 2012
    ..We find also increased shedding of urinary ApoM that precedes changes in blood urea nitrogen and serum creatinine in wild type mice as well as human ApoM transgenic mice exposed to cisplatin...
  4. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter W Nathanielsz; Fiscal Year: 2012
    ..Innovation: Our preliminary data show that 30% MNR produces F NR (decreased F blood urea nitrogen, amino acids and growth factors)...
  5. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ..The proposed studies incorporate traditional measures of clinical nephrotoxicity (serum creatinine, blood urea nitrogen) and a novel biomarker (urinary Kim-1) to detect the phenotype of acute kidney injury...
  6. Regulation of Podocyte Differentiation by the Transcription Factor EBF1
    Jackie Fretz; Fiscal Year: 2013
    ..vascularization, crescents, severely effaced podocytes, and these mice exhibit albuminuria and elevated blood urea nitrogen. We believe that Ebf1 is functioning during an intermediate to late stage of podocyte differentiation...
  7. CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve
    Sudhir V Shah; Fiscal Year: 2011
    ..Patients with kidney disease have higher levels of blood urea nitrogen, which can be transformed into products that modify proteins by a process known as carbamylation...
  8. Novel Small-molecule TNF-a Modulators as Chemoprotective Agents
    Jiajiu Shaw; Fiscal Year: 2012
    ..Based on this SBIR Phase I study, UTL-5g has been shown to reduce levels of blood urea nitrogen (BUN), creatinine, aspartate transaminase (AST), and alanine transaminase (ALT) elevated by cisplatin, ..
  9. Cardio-renal phenotype and prognosis in chronic heart failure
    Jeffrey M Testani; Fiscal Year: 2012
    ..e., RD). The risk attributable to RD appears to be isolated to patients with an elevated blood urea nitrogen to creatinine ratio (BUN/Cr), which is a surrogate for renal neurohormonal activation...
  10. Development of a Urea Biosensor Using the UreR Protein
    HARRY MOBLEY; Fiscal Year: 2004
    ..The blood urea nitrogen (BUN) test, a routine but critical clinical laboratory assay used to evaluate renal function, quantifies ..
  11. CHLOROANILINE-INDUCED NEPHROTOXICITY
    GARY RANKIN; Fiscal Year: 1992
    ..content, pH, osmolality), in vitro accumulation of organic ions by renal cortical slices, kidney weight, blood urea nitrogen (BUN) concentration and histology (light and electron microscopy)...
  12. Multi-slice Perfusion MR Imaging of the Human Kidney
    H Gach; Fiscal Year: 2004
    ..Bioassays of serum creatinine, blood urea nitrogen (BUN), and urine output may indicate the occurrence of renal dysfunction but not the type...
  13. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2000
    ..and enzymuria), (b) blood analysis (serum tumor necrosis factor-alpha, interleukin-1 and interleukin-6 vs blood urea nitrogen), (c) histology (localization of 4-hydroxynonenal- and malondialdehyde-adducts vs histopathology), (d) ..
  14. ANTAGONISTS FOR CIS-PLATINUM NEPHROTOXICITY
    Mark Jones; Fiscal Year: 1990
    ..function in experimental animals (rats) will be monitored (via measurement of serum creatinine levels and blood urea nitrogen values) as the animals are taken through various protocols designed to allow the administration of cis-..
  15. DYSPHAGIA THERAPY FOLLOWING STROKE--CONTROLLED TRIAL
    Michael Reding; Fiscal Year: 1992
    ..Dependent variables will assess the following: state of hydration (serum electrolytes, blood urea nitrogen (BUN), BUN to creatinine ratio, and urine specific gravity); calorie-nitrogen balance (body weight, serum ..
  16. Breath Ammonia Measurements for Dialysis Assessment
    C Patel; Fiscal Year: 2001
    ..We show correlations with reductions in blood urea nitrogen (BUN: approximately 90mg/dL to approximately 30mg/dL) and creatinine (approximately 14mg/dL to ..
  17. B-2 Microglobulin:Renal Biomarker Workplace U Exposure
    Susan Pinney; Fiscal Year: 2004
    ..the relationship between beta-2-microglobulin and other parameters of renal function (serum creatinine, blood urea nitrogen, urinary protein, blood and glucose in urine) and compare those relationships in workers to the unexposed ..
  18. CONVENTIONAL VS HIGH PROTEIN INTAKE RATE TO ELBW NEONATE
    Patti Thureen; Fiscal Year: 2002
    ..Safety will be assessed by plasma amino acid and blood urea nitrogen concentrations...
  19. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2009
    ..each of 11 routinely available acute physiology measures (blood pressure, heart rate, temperature, glucose, blood urea nitrogen, creatinine, sodium, potassium, billirubin, hematocrit and white blood count) and death in 2,250 critically ..
  20. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  21. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  22. Technology and Endothelial Biology of Kidney Injury Molecule-1
    Vishal Vaidya; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  24. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
  25. Hospital and Community Acquired Acute Renal Failure
    Glenn Chertow; Fiscal Year: 2006
    ..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
  26. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  27. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  28. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  29. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  30. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2009
    ..We believe the proposed work will allow a more complete understanding of the causes of renal function decline and lead to the development of public health interventions to prevent this considerable public health problem. ..
  31. Molecular Analysis of Ureteric Reflux
    Robert Mak; Fiscal Year: 2006
    ..A clinical database of primary VUR and RN will be set up to establish correlations between biomarkers and phenotype and to test the sensitivity and specificity of these markers for detecting primary VUR and RN. ..
  32. SORBENTS+ENGINEERED BACTERIA AS GUT-BASED UREMIA THERAPY
    Natarajan Ranganathan; Fiscal Year: 2002
    ..It is equally feasible that our oral formulation may also have applications as a adjunct therapy for dialysis. ..
  33. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  34. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
    ..abstract_text> ..
  35. Urinary Biomarkers for Steroid Resistant Nephrotic Syndr
    Robert Mak; Fiscal Year: 2005
    ..We believe that data from the current study will improve our diagnostic and therapeutic strategy and may provide clues to the pathogenetic significance of the identified biomarkers. ..
  36. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  37. A dietary supplement for augmenting kidney function
    Natarajan Ranganathan; Fiscal Year: 2004
    ..The fully developed product will have immense benefits for the uremic patients both in a higher quality of life and a decrease in the financial burden associated with renal dysfunction therapy. ..
  38. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  39. Feasibility Study of Three NCEs for Rheumatoid Arthritis
    Jiajiu Shaw; Fiscal Year: 2004
    ..Ultimately, the successful drug candidate will provide a significantly improved therapy for patients suffering from Rheumatoid Arthritis. ..
  40. Ischemia-induced Actin Cytoskeletal Alterations
    Bruce Molitoris; Fiscal Year: 2008
    ..abstract_text> ..
  41. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2008
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  42. Estrogen in pathogenesis of tubulointerstitial disease
    Christine Maric; Fiscal Year: 2003
    ..abstract_text> ..
  43. PREVENTION OF HEMODIALYSIS VASCULAR ACCESS STENOSIS
    Alfred K Cheung; Fiscal Year: 2010
    ..It is highly likely that, within this 5-year proposal, the results of this project can be applied to pilot clinical studies. ..
  44. NY Stroke Rehabilitation Clinical Trials Network
    Michael Reding; Fiscal Year: 2003
    ....
  45. RAB5 AND PI-3-KINASE AND GENTAMICIN TOXICITY
    Bruce Molitoris; Fiscal Year: 2002
    ..By performing these studies, it is hoped that formulation of specific therapies to delay and/or inhibit this toxicity will become possible. ..
  46. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  47. Dietary Protein, Acid Loading and Bone Metabolism
    BASIL INCE; Fiscal Year: 2003
    ..abstract_text> ..
  48. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  49. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  50. Regulation of Pendrin by Angiotensin II
    Susan Wall; Fiscal Year: 2007
    ..This proposal will explore how pendrin controls absorption of Cl- by the kidney and why activity of pendrin and ENaC are so dependent on each other. ..
  51. Mechanisms of Hawthorn Action in Heart Failure
    Barry Bleske; Fiscal Year: 2005
    ..The results from this study will have important translation to both the basic and clinical research settings. ..
  52. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Gregg Fonarow; Fiscal Year: 2006
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  53. A Canine Model for Human X-Linked Ectodermal Dysplasia
    Margret Casal; Fiscal Year: 2007
    ..Furthermore, the HED dogs will be examined to demonstrate that a specific immune deficiency is responsible for pulmonary disease rather than the previously thought lack of respiratory mucoid glands. ..
  54. Lysophosphatidic Acid Receptors and Acute Renal Failure
    MARK OKUSA; Fiscal Year: 2007
    ..Furthermore, these studies will provide the foundation for future human clinical trials of acute renal failure and renal allograft preservation. ..
  55. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..e., is the "hypercoagulability" observed in patients with SCD a primary cause of the vasoocclusion or is it simply a secondary event that is observed in this clinical setting. ..
  56. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  57. Retinal Microvascular Characteristics/Vascular Disorders
    Ronald Klein; Fiscal Year: 2003
    ..abstract_text> ..
  58. KALLISTATIN IN HYPERTENSION
    Julie Chao; Fiscal Year: 2008
    ..abstract_text> ..
  59. Endonuclease dificiency in breast cancer progression
    Alexei Basnakian; Fiscal Year: 2006
    ..The next specific aim will be focused on functional studies to determine the role of EndoG in dedifferentiation and invasiveness of breast cancer cells in vitro (Specific Aim 2). ..
  60. PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVAL
    Barbara Klein; Fiscal Year: 2002
    ....
  61. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  62. Autologous Cellular Therapy for Ventricular Dysfunction
    Robert Kormos; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  64. Pharmacogenetic Optimization of Anticoagulation Therapy
    Nita Limdi; Fiscal Year: 2007
    ..With the award of the K23 grant, structured training, guidance of mentors, environment and institutional support provided by the University, I will develop the skills necessary for a productive career in pharmacogenetics research. ..