tuberculin test

Summary

Summary: One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.

Top Publications

  1. pmc Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update
    Madhukar Pai
    McGill University and Montreal Chest Institute, Montreal, Quebec, Canada
    Ann Intern Med 149:177-84. 2008
  2. doi Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis
    R Diel
    Dept of Pneumology, Medical School Hanover, Hanover, Germany
    Eur Respir J 37:88-99. 2011
  3. doi Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis
    Roland Diel
    Department of Pulmonary Medicine, Hannover Medical School MHH, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 137:952-68. 2010
  4. ncbi Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques
    R de la Rua-Domenech
    Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
    Res Vet Sci 81:190-210. 2006
  5. pmc Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 56:230-8. 2011
  6. doi Approaches to tuberculosis screening and diagnosis in people with HIV in resource-limited settings
    Michael J A Reid
    Department of Social Medicine, Montefiore Medical Center, Bronx, NY 10467, USA
    Lancet Infect Dis 9:173-84. 2009
  7. pmc Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e8517. 2009
  8. pmc High prevalence and increased severity of pathology of bovine tuberculosis in Holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia
    Gobena Ameni
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 14:1356-61. 2007
  9. ncbi A systematic review of rapid diagnostic tests for the detection of tuberculosis infection
    J Dinnes
    Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 11:1-196. 2007
  10. doi Highly discordant T cell responses in individuals with recent exposure to household tuberculosis
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa
    Thorax 64:840-6. 2009

Detail Information

Publications301 found, 100 shown here

  1. pmc Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update
    Madhukar Pai
    McGill University and Montreal Chest Institute, Montreal, Quebec, Canada
    Ann Intern Med 149:177-84. 2008
    ..A recent meta-analysis showed that IGRAs have high specificity, even among populations that have received bacille Calmette-Guérin (BCG) vaccination. Sensitivity was suboptimal for TST and IGRAs...
  2. doi Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis
    R Diel
    Dept of Pneumology, Medical School Hanover, Hanover, Germany
    Eur Respir J 37:88-99. 2011
    ..IGRAs may have a relative advantage over the TST in detecting LTBI and allow the exclusion of M. tuberculosis infection with higher reliability...
  3. doi Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis
    Roland Diel
    Department of Pulmonary Medicine, Hannover Medical School MHH, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Chest 137:952-68. 2010
    ..1% (95% CI, 0.052-0.071), respectively, among immunosuppressed hosts. The newest commercial IGRAs are superior, in comparison with the TST, for detecting confirmed active TB disease, especially when performed in developed countries...
  4. ncbi Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques
    R de la Rua-Domenech
    Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
    Res Vet Sci 81:190-210. 2006
    ..The strategic deployment of ancillary in vitro tests alongside the primary skin tests has enhanced the detection of M. bovis-infected cattle and reduced the number of animals slaughtered as false positives...
  5. pmc Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis
    Adithya Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 56:230-8. 2011
    ..To determine whether interferon-gamma release assays (IGRAs) improve the identification of HIV-infected individuals who could benefit from latent tuberculosis infection therapy...
  6. doi Approaches to tuberculosis screening and diagnosis in people with HIV in resource-limited settings
    Michael J A Reid
    Department of Social Medicine, Montefiore Medical Center, Bronx, NY 10467, USA
    Lancet Infect Dis 9:173-84. 2009
    ..However, until simpler, cheaper, and more sensitive diagnostics for tuberculosis are available in peripheral healthcare settings, a strategy must be developed that uses current evidence to combine available screening tools...
  7. pmc Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e8517. 2009
    ..However, the effect of a preceding TST on subsequent IGRA results has been reported in studies with apparently conflicting results...
  8. pmc High prevalence and increased severity of pathology of bovine tuberculosis in Holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia
    Gobena Ameni
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 14:1356-61. 2007
    ..Holsteins), which were kept on pasture in the central highlands of Ethiopia, using a comparative intradermal tuberculin test, postmortem examination, and bacteriology. The overall prevalence of bovine TB was 13...
  9. ncbi A systematic review of rapid diagnostic tests for the detection of tuberculosis infection
    J Dinnes
    Wessex Institute for Health Research and Development, University of Southampton, UK
    Health Technol Assess 11:1-196. 2007
    ..To evaluate the effectiveness of available rapid diagnostic tests to identify tuberculosis (TB) infection...
  10. doi Highly discordant T cell responses in individuals with recent exposure to household tuberculosis
    A C Hesseling
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa
    Thorax 64:840-6. 2009
    ..There are limited data comparing interferon-gamma release assays (IGRAs) for the detection of Mycobacterium tuberculosis infection in highly endemic settings...
  11. doi Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute Department of Medicine, University of Cape Town, Cape Town, South Africa
    Am J Respir Crit Care Med 180:49-58. 2009
    ..Assessment of within-subject IGRA variability will aid in establishing thresholds for conversions and reversions, and interpretation of serial testing results...
  12. pmc Serial testing of health care workers for tuberculosis using interferon-gamma assay
    Madhukar Pai
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA
    Am J Respir Crit Care Med 174:349-55. 2006
    ..Although interferon-gamma (IFN-gamma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing performance is unknown...
  13. doi Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis
    A M Mandalakas
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Int J Tuberc Lung Dis 15:1018-32. 2011
    ..Children infected with Mycobacterium tuberculosis have significant risk of developing tuberculosis(TB) and can therefore benefit from preventive therapy...
  14. doi LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement
    U Mack
    Lovisenberg Diakonale Sykehus, Oslo, Norway
    Eur Respir J 33:956-73. 2009
    ..In summary, the main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy...
  15. doi Negative and positive predictive value of a whole-blood interferon-γ release assay for developing active tuberculosis: an update
    Roland Diel
    Department of Pneumology, Medical School Hannover MHH, Carl Neuberg Str 1, 30625 Hannover, Germany
    Am J Respir Crit Care Med 183:88-95. 2011
    ..only limited data are available on the predictive value of interferon-γ release assays for progression from latent tuberculosis infection to active tuberculosis (TB)...
  16. doi Interferon gamma release assays: principles and practice
    Ajit Lalvani
    Tuberculosis Research Unit, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Enferm Infecc Microbiol Clin 28:245-52. 2010
    ..The role of IGRAs in active TB is less clear but they may be useful as adjunctive tests in the diagnostic work-up of an individual with suspected TB. Finally, recent developments and future directions in IGRA development are reviewed...
  17. pmc Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
    Anil Pooran
    Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
    BMC Pulm Med 10:7. 2010
    ..tb...
  18. ncbi Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: performance of a Mycobacterium tuberculosis antigen-specific interferon gamma assay
    G Matulis
    Department of Rheumatology and Clinical Immunology Allergology, University of Bern, Switzerland
    Ann Rheum Dis 67:84-90. 2008
    ..To analyse the performance of a new M. tuberculosis-specific interferon gamma (IFNgamma) assay in patients with chronic inflammatory diseases who receive immunosuppressive drugs, including tumour necrosis factor alpha (TNFalpha) inhibitors...
  19. ncbi Priorities for the treatment of latent tuberculosis infection in the United States
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    N Engl J Med 350:2060-7. 2004
    ..Currently, the rate of completion of treatment is low...
  20. doi Comparing QuantiFERON-tuberculosis gold, T-SPOT tuberculosis and tuberculin skin test in HIV-infected individuals from a low prevalence tuberculosis country
    Christoph Stephan
    HIVCENTER at Medical Department II, Hospital of Johann Wolfgang Goethe University, Frankfurt, Germany
    AIDS 22:2471-9. 2008
    ..To evaluate the interferon-gamma-releasing assays QuantiFERON-tuberculosis (TB) Gold and T-SPOT.TB in addition to tuberculin skin test (TST) for diagnosis of latent tuberculosis infection in HIV patients...
  21. doi Interferon-gamma release assays versus tuberculin skin testing for detection of latent tuberculosis in chronic haemodialysis patients
    Pierre Alain Triverio
    Division of Nephrology, Geneva University Hospital, 1211 Geneva 14, Switzerland
    Nephrol Dial Transplant 24:1952-6. 2009
    ..End stage renal disease increases the risk of reactivating latent tuberculosis (LTBI). Interferon-gamma release assays (IGRA) are an alternative to the tuberculin skin test (TST) for detecting LTBI...
  22. pmc Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal
    Christian Lienhardt
    Institut de Recherche pour le Developpement, Programme Tuberculose, Dakar, Senegal
    PLoS ONE 5:e10508. 2010
    ..To address this, we investigated the response to TST and IGRA in household contacts of infectious TB cases in a TB high-burden country and the potential correlation with development of TB...
  23. doi Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Ophthalmology 116:1391-6. 2009
    ..To determine the role of the QuantiFERON-TB Gold In-Tube (QFT) (Cellestis Inc., Carnegie, Australia) assay in the diagnosis of tuberculosis (TB) uveitis...
  24. doi Repeated cross-sectional skin testing for bovine tuberculosis in cattle kept in a traditional husbandry system in Ethiopia
    R Tschopp
    Swiss Tropical Institute, CH 4002 Basel, Switzerland
    Vet Rec 167:250-6. 2010
    ..The comparative intradermal tuberculin test with two diagnostic thresholds were used to define positive test results, one according to the World ..
  25. doi Using latent class analysis to estimate the test characteristics of the γ-interferon test, the single intradermal comparative tuberculin test and a multiplex immunoassay under Irish conditions
    Tracy A Clegg
    Centre for Veterinary Epidemiology and Risk Analysis, Veterinary Sciences Centre, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Microbiol 151:68-76. 2011
    ..devoted to improving the existing diagnostic tests for bovine tuberculosis (single intradermal comparative tuberculin test [SICTT] and γ-interferon assay [γ-IFN]) and to develop new tests...
  26. pmc T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India
    M Pai
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 13:84-92. 2009
    ..In a pilot study, we determined conversions and reversions using QuantiFERON-TB Gold In-Tube((R)) (QFT) among household contacts of TB cases, and evaluated the effect of using various definitions and criteria for conversions...
  27. doi Comparison of interferon-gamma release assays and tuberculin skin test in predicting active tuberculosis (TB) in children in the UK: a paediatric TB network study
    Alasdair R J Bamford
    Academic Department of Paediatrics, Imperial College London, London, UK
    Arch Dis Child 95:180-6. 2010
    ..The authors examined the sensitivity of commercially available IGRA to diagnose active TB in children in the UK compared with the tuberculin skin test (TST)...
  28. pmc Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South Africa
    R Wood
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 14:406-12. 2010
    ..Crowded townships of Cape Town, South Africa, where human immunodeficiency virus (HIV) prevalence and tuberculosis (TB) notification rates are among the highest in the world...
  29. ncbi High level of discordant IGRA results in HIV-infected adults and children
    A M Mandalakas
    Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Int J Tuberc Lung Dis 12:417-23. 2008
    ..Tygerberg district, Western Cape Province, South Africa...
  30. pmc Tuberculosis among health-care workers in low- and middle-income countries: a systematic review
    Rajnish Joshi
    Division of Epidemiology, School of Public Health, University of California Berkeley, Berkeley, California, United States of America
    PLoS Med 3:e494. 2006
    ..Most health-care facilities in these countries lack resources to prevent nosocomial transmission of tuberculosis (TB)...
  31. doi Performance of tests for latent tuberculosis in different groups of immunocompromised patients
    Luca Richeldi
    Section of Respiratory Diseases, Department of Oncology, Hematology and Respiratory Diseases, University of Modena and Reggio Emilia, Italy
    Chest 136:198-204. 2009
    ....
  32. doi Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts
    S V Kik
    KNCV Tuberculosis Foundation, PO Box 146, 2501 CC, The Hague, The Netherlands
    Eur Respir J 35:1346-53. 2010
    ..3% (95% CI 1.3-5.3%) for T-SPOT.TB. Sensitivity was 100%, 88%, 63% and 75%, respectively. The predictive values of QFT-GIT, T-SPOT.TB and TST for progression to TB disease among immigrant close contacts were comparable...
  33. pmc The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa
    Hassan Mahomed
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 6:e17984. 2011
    ..This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000...
  34. pmc Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses
    Michael Coad
    TB Research Group, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Vet Res 41:14. 2010
    ..The desensitising effect is associated with decreased IL-1beta and elevated IL-10 responses, but importantly, does not influence antigen specific IFN-gamma responses...
  35. pmc Poor concordance between interferon-gamma release assays and tuberculin skin tests in diagnosis of latent tuberculosis infection among HIV-infected individuals
    Naasha J Talati
    Division of Infectious Diseases, Emory University, School of Medicine, Atlanta, GA, USA
    BMC Infect Dis 9:15. 2009
    ..A new generation of diagnostic tests, the interferon-gamma release assays (IGRAs), have been developed for the detection of latent tuberculosis infection (LTBI). Limited data are available on their use in HIV-infected persons...
  36. pmc Improved diagnostic evaluation of suspected tuberculosis
    Davinder P S Dosanjh
    Tuberculosis Immunology Group, Imperial College London, London, United Kingdom
    Ann Intern Med 148:325-36. 2008
    ..The role of new T-cell-based blood tests for tuberculosis in the diagnosis of active tuberculosis is unclear...
  37. doi Comparative performance of tuberculin skin test, QuantiFERON-TB-Gold In Tube assay, and T-Spot.TB test in contact investigations for tuberculosis
    Roland Diel
    School of Public Health c o Institute of Medical Sociology, University of Dusseldorf, Dusseldorf, Germany
    Chest 135:1010-8. 2009
    ....
  38. ncbi Contact screening and latent TB infection treatment in Singapore correctional facilities
    C B E Chee
    Department of Respiratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore
    Int J Tuberc Lung Dis 9:1248-52. 2005
    ..Singapore, a city-state with a tuberculosis (TB) incidence rate of 47 per 100000 population in 2000...
  39. doi Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection in hemodialysis patients
    E C Seyhan
    Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey
    Transpl Infect Dis 12:98-105. 2010
    ..The QuantiFERON-TB Gold assay (QFT-G) may be more accurate than the tuberculin skin test (TST) in the detection of LTBI. We prospectively compared the results of QFT-G to TST in HD patients...
  40. doi Advances in ante-mortem diagnosis of tuberculosis in cattle
    B M Buddle
    AgResearch, Hopkirk Research Institute, Private Bag 11008, Palmerston North 4442, New Zealand
    N Z Vet J 57:173-80. 2009
    ..The use of these new ancillary tests in association with skin-testing will improve the detection of M. bovis-infected cattle and reduce the unnecessary slaughter of false-positive reactors...
  41. pmc Programmatic impact of QuantiFERON-TB Gold In-Tube implementation on latent tuberculosis diagnosis and treatment in a public health clinic
    Maunank Shah
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e36551. 2012
    ..In March, 2010, the Baltimore City Health Department (BCHD) introduced routine QFT-GIT testing for individuals referred to the TB program for suspected latent TB infection (LTBI)...
  42. doi Validity of interferon-γ-release assays for the diagnosis of latent tuberculosis in haemodialysis patients
    W K Chung
    Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea
    Clin Microbiol Infect 16:960-5. 2010
    ..The frequency of indeterminate results was higher for the QFT (12.6%) compared with the TSPOT (4.8%). In conclusion, the IGRAs can be useful for the diagnosis of latent TB infection in haemodialysis patients...
  43. doi Programmatic impact of using QuantiFERON®-TB Gold in routine contact investigation activities
    J A Grinsdale
    Tuberculosis Control Section, Department of Public Health, City and County of San Francisco, San Francisco General Hospital, Ward 94 1001 Potrero Ave, San Francisco, CA 94110, USA
    Int J Tuberc Lung Dis 15:1614-20. 2011
    ....
  44. doi Diagnosis of tuberculosis in dialysis patients: current strategy
    Liviu Segall
    Nephrology Department, Dr C I Parhon Hospital, University of Medicine and Pharmacy Gr T Popa, Iasi, Romania
    Clin J Am Soc Nephrol 5:1114-22. 2010
    ..Therefore, current strategy in dialysis patients should use these tests instead of TST for LTBI screening and as an aid for the diagnosis of active TB...
  45. doi Ocular tuberculosis: a clinicopathologic and molecular study
    Keith J Wroblewski
    Armed Forces Institute of Pathology, Washington, DC, USA
    Ophthalmology 118:772-7. 2011
    ..To analyze the clinical profiles, histopathologic features, and Mycobacterium tuberculosis polymerase chain reaction testing in patients with ocular tuberculosis...
  46. pmc Serial testing with the interferon-γ release assay in Portuguese healthcare workers
    José Torres Costa
    Occupational Health Division, Hospital S Joao, Alameda Professor Hernani Monteiro, Porto, Portugal
    Int Arch Occup Environ Health 84:461-9. 2011
    ..However, data concerning conversion and reversion rates in serial testing of healthcare workers (HCWs) with an interferon-γ release assay are sparse...
  47. ncbi Prevalence of tuberculosis infection in the United States population: the national health and nutrition examination survey, 1999-2000
    Diane E Bennett
    Centers for Disease Control and Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, Georgia, USA
    Am J Respir Crit Care Med 177:348-55. 2008
    ..The goal for tuberculosis (TB) elimination in the United States is a TB disease incidence of less than 1 per million U.S. population by 2010, which requires that the latent TB infection (LTBI) prevalence be less than 1% and decreasing...
  48. pmc First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent
    Winnie Bergstedt
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e11277. 2010
    ..Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity...
  49. pmc Recent advances in testing for latent TB
    Neil W Schluger
    Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Chest 138:1456-63. 2010
    ....
  50. pmc Performance of QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of Mycobacterium tuberculosis (Mtb) infection in Afar Pastoralists, Ethiopia
    Mengistu Legesse
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
    BMC Infect Dis 10:354. 2010
    ....
  51. doi Ocular signs predictive of tubercular uveitis
    Amod Gupta
    Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Am J Ophthalmol 149:562-70. 2010
    ..To determine ocular signs predictive of tubercular uveitis...
  52. doi Agreement between Quantiferon-TB gold test and tuberculin skin test in the identification of latent tuberculosis infection in patients with rheumatoid arthritis and ankylosing spondylitis
    Nevsun Inanc
    Division of Rheumatology, Department of Pulmonary and Critical Care, Marmara University Medical School, Istanbul, Turkey
    J Rheumatol 36:2675-81. 2009
    ....
  53. doi T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease
    Chi Chiu Leung
    Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China
    Am J Respir Crit Care Med 182:834-40. 2010
    ..Silicosis is a well-recognized risk factor for tuberculosis (TB)...
  54. pmc Predictors of persistently positive Mycobacterium-tuberculosis-specific interferon-gamma responses in the serial testing of health care workers
    Felix C Ringshausen
    Department of Medicine III Pneumology, Allergology and Sleep Medicine, University Hospital Bergmannsheil, Bochum, Germany
    BMC Infect Dis 10:220. 2010
    ....
  55. ncbi Interferon-gamma release assays in immigrant contacts and effect of remote exposure to Mycobacterium tuberculosis
    S V Kik
    KNCV Tuberculosis Foundation, The Hague, The Netherlands
    Int J Tuberc Lung Dis 13:820-8. 2009
    ..TB-in immigrant contacts of sputum smear-positive TB patients...
  56. pmc Annual risk of tuberculous infection using different methods in communities with a high prevalence of TB and HIV in Zambia and South Africa
    Kwame Shanaube
    ZAMBART Project, University Teaching Hospital, Lusaka, Zambia
    PLoS ONE 4:e7749. 2009
    ..This paper explores the implications of using different methods to estimate prevalence of infection and ARTI. The effect of BCG vaccination on these estimates is also investigated...
  57. doi A prospective large-scale study of methods for the detection of latent Mycobacterium tuberculosis infection in refugee children
    Michaela Lucas
    Department of Clinical Immunology, Royal Perth Hospital, GPO Box X2213, Perth WA 6847, Australia
    Thorax 65:442-8. 2010
    ..However, both IGRAs have methodological and performance characteristics that limit their usefulness in refugee children, highlighting the need for continued development of screening strategies...
  58. pmc Appraisal of interpretation criteria for the comparative intradermal tuberculin test for diagnosis of tuberculosis in cattle in central Ethiopia
    Gobena Ameni
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 15:1272-6. 2008
    ..5%). Thus, our study demonstrates the importance of defining local, relevant cutoff values to maximize test sensitivity, and we suggest the application of the >2-mm cutoff for testing of cattle in central Ethiopia...
  59. pmc Revisiting rates of reactivation tuberculosis: a population-based approach
    C Robert Horsburgh
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Am J Respir Crit Care Med 182:420-5. 2010
    ..10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since...
  60. pmc Discriminating between latent and active tuberculosis with multiple biomarker responses
    Marc Frahm
    Center for AIDS Research, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Tuberculosis (Edinb) 91:250-6. 2011
    ..The combination of IL-15 and MCP-1 responses was accurate in distinguishing persons with active tuberculosis from persons with latent tuberculosis in this study...
  61. ncbi Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005
    Paul A Jensen
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Atlanta, GA 30333, USA
    MMWR Recomm Rep 54:1-141. 2005
    ..tuberculosis. The term "setting" has been chosen over the term "facility," used in the previous guidelines, to broaden the potential places for which these guidelines apply...
  62. pmc Enhanced diagnosis of HIV-1-associated tuberculosis by relating T-SPOT.TB and CD4 counts
    T Oni
    Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Eur Respir J 36:594-600. 2010
    ..A strong association between the degree of sputum positivity and T-SPOT.TB score was found. The sensitivity of the T-SPOT.TB assay in active disease may be less impaired by advanced immunosuppression...
  63. ncbi Risk factors associated with the occurrence of bovine tuberculosis in cattle in the Southern Highlands of Tanzania
    R R Kazwala
    Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania
    Vet Res Commun 25:609-14. 2001
    ..risk factors was based on comparisons of the reactivity of the cattle in the single comparative intradermal tuberculin test (SCITT). Older cattle were more affected by the disease than yearlings and calves (p<0.0001)...
  64. pmc Cattle husbandry in Ethiopia is a predominant factor affecting the pathology of bovine tuberculosis and gamma interferon responses to mycobacterial antigens
    Gobena Ameni
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia
    Clin Vaccine Immunol 13:1030-6. 2006
    ..A difference in the cellular immune response between zebu and Holstein cattle was observed, while tuberculosis lesion severities were identical in the two breeds, when both were kept in a pasture...
  65. pmc Role of QuantiFERON-TB gold, interferon gamma inducible protein-10 and tuberculin skin test in active tuberculosis diagnosis
    Basirudeen Syed Ahamed Kabeer
    Department of Immunology, Tuberculosis Research Centre ICMR, Chennai, Tamil Nadu, India
    PLoS ONE 5:e9051. 2010
    ....
  66. pmc Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection
    Saverio V Capuano
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 71:5831-44. 2003
    ..In addition, this model will provide an opportunity to study the latent M. tuberculosis infection observed in approximately 90% of all infected humans...
  67. doi Annual incidence of latent tuberculosis infection among newly employed nurses at a tertiary care university hospital
    Kwangha Lee
    Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138 736, Korea
    Infect Control Hosp Epidemiol 30:1218-22. 2009
    ..To investigate the annual rate of tuberculosis (TB) infection among newly employed nurses using both tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT-G; Cellestis Limited) assay...
  68. pmc Association between smoking and tuberculosis infection: a population survey in a high tuberculosis incidence area
    S den Boon
    Centre for TB Research and Education, Department of Paediatrics and Child Health, Stellenbosch University, P O Box 19063, 7505 Tygerberg, Cape Town, South Africa
    Thorax 60:555-7. 2005
    ..The aim of this study was to determine the association between smoking and M tuberculosis infection...
  69. doi QuantiFERON-TB Gold and the TST are both useful for latent tuberculosis infection screening in autoimmune diseases
    F Bartalesi
    Infectious and Tropical Diseases Unit, Careggi Hospital, University of Florence, Florence, Italy
    Eur Respir J 33:586-93. 2009
    ....
  70. ncbi Interferon-gamma release assay improves the diagnosis of tuberculosis in children
    Leila Bianchi
    Department of Pediatrics, University of Florence, Florence, Italy
    Pediatr Infect Dis J 28:510-4. 2009
    ..The aim of the present study was to evaluate the performance of an enzyme-linked immunosorbent assay (ELISA)-based IGRA for detecting TB in children...
  71. doi Tuberculosis among household contacts of multidrug-resistant tuberculosis patients in Delhi, India
    N Singla
    Department of Epidemiology, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, New Delhi, India
    Int J Tuberc Lung Dis 15:1326-30. 2011
    ..Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases (LRS), a tertiary level tuberculosis (TB) institute in Delhi, India...
  72. ncbi Use of the QuantiFERON-TB Gold test to confirm latent tuberculosis infection in a Canadian tuberculosis clinic
    Dennis Kunimoto
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Int J Tuberc Lung Dis 13:726-30. 2009
    ..Capital Health Tuberculosis (TB) Clinic, Edmonton, Alberta, Canada...
  73. doi Comparison of interferon {gamma} release assays and conventional screening tests before tumour necrosis factor {alpha} blockade in patients with inflammatory arthritis
    J Martin
    Departments of Rheumatology, Respiratory Medicine and Radiology, St Vincent s University Hospital, Dublin 4, Ireland
    Ann Rheum Dis 69:181-5. 2010
    ....
  74. doi Serial testing of Malaysian health care workers with QuantiFERON®-TB Gold In-Tube
    S Rafiza
    Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia
    Int J Tuberc Lung Dis 16:163-8. 2012
    ..Serial testing for tuberculosis (TB) exposure has been advocated among health care workers (HCWs) at risk of nosocomial infection...
  75. ncbi Infection and disease among household contacts of patients with multidrug-resistant tuberculosis
    L Teixeira
    Nucleo de Doencas Infecciosas, Universidade Federal do Espirito Santo, Vitoria, Brazil
    Int J Tuberc Lung Dis 5:321-8. 2001
    ..Urban public teaching and referral hospital in Espirito Santo, Brazil...
  76. ncbi Species-specific antigenic Mycobacterium tuberculosis proteins tested by delayed-type hypersensitivity response
    S N M Hanif
    Department of Microbiology, Faculty of Medicine, Kuwait University, Jabriya, Kuwait
    Int J Tuberc Lung Dis 14:489-94. 2010
    ....
  77. doi Identifying recent Mycobacterium tuberculosis transmission in the setting of high HIV and TB burden
    Junior Mutsvangwa
    Biomedical Research and Training Institute, Harare, Zimbabwe
    Thorax 65:315-20. 2010
    ....
  78. ncbi Assessing the validity of tuberculin skin test readings by trained professionals and patients
    P O Ozuah
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Chest 116:104-6. 1999
    ..To assess the validity of purified protein derivative (PPD) readings by patients and trained health-care professionals as compared with a calibrated model...
  79. doi Screening for latent tuberculosis infection in South Korean healthcare workers using a tuberculin skin test and whole blood interferon-gamma assay
    Kyung Jong Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Scand J Infect Dis 42:672-8. 2010
    ..03; p = 0.031). Further, the IGRA can more accurately discriminate LTBI compared to the TST, based on the risk of TB exposure. These results suggest that the IGRA is diagnostically useful for LTBI in South Korean HCWs...
  80. doi Influence of previous tuberculin skin test on serial IFN-γ release assays
    Ilaria Sauzullo
    Dipartimento di Sanità Pubblica e Malattie Infettive, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University, Piazzale Aldo Moro 1, 00185, Rome, Italy
    Tuberculosis (Edinb) 91:322-6. 2011
    ....
  81. ncbi Thinking in three dimensions: a web-based algorithm to aid the interpretation of tuberculin skin test results
    D Menzies
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Canada
    Int J Tuberc Lung Dis 12:498-505. 2008
    ..Accurate interpretation of TST requires consideration of three dimensions-the size of the skin reaction, the positive predictive value (PPV) and risk of disease...
  82. doi Clinical utility of the QuantiFERON TB-2G test for elderly patients with active tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701 0192, Japan
    Chest 133:1196-202. 2008
    ....
  83. doi Performance of commercial blood tests for the diagnosis of latent tuberculosis infection in children and adolescents
    Barbara Maria Bergamini
    University of Modena and Reggio Emilia, Department of Respiratory Diseases, Policlinico Hospital of Modena, Via del Pozzo 71, 41100 Modena, Italy
    Pediatrics 123:e419-24. 2009
    ..TB (Oxford Immunotec, Abingdon, United Kingdom) show promise of greater accuracy, but they may also be affected by impaired cellular immunity, resulting in indeterminate results (ie, insufficient response in positive-control wells)...
  84. doi Prospective comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube assay for the detection of latent tuberculosis infection among healthcare workers in a low-incidence setting
    Kristin J Cummings
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Infect Control Hosp Epidemiol 30:1123-6. 2009
    ..Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression...
  85. doi Positive conversion of tuberculin skin test and performance of interferon release assay to detect hidden tuberculosis infection during anti-tumor necrosis factor agent trial
    Jeong Ha Park
    Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, South Korea
    J Rheumatol 36:2158-63. 2009
    ....
  86. doi Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infection
    L Leidl
    Research Center Borstel, Germany
    Eur Respir J 35:619-26. 2010
    ..46). In HIV-1 infection, TST and QFT-G-IT immune responses are both strongly related to the degree of immunodeficiency, while results of the T-Spot.TB are independent of the level of CD4+ T-cell depletion...
  87. ncbi Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South Africa
    H Mahomed
    South African Tuberculosis Vaccine Initiative SATVI, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:331-6. 2011
    ..A high tuberculosis (TB) burden area in South Africa (notification rate for all TB cases 1400 per 100 000 population)...
  88. pmc Immunogenicity of Mycobacterium tuberculosis RD1 region gene products in infected cattle
    A S Mustafa
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Clin Exp Immunol 130:37-42. 2002
    ..effectively prohibited because BCG, the only potentially available cattle TB vaccine, compromises the current tuberculin test. The main objective of this study was to identify specific antigens, which could increase the test ..
  89. pmc Low sensitivity of T-cell based detection of tuberculosis among HIV co-infected Tanzanian in-patients
    C Seshadri
    Massachusetts General Hospital, Gray Jackson 504, 55 Fruit Street, Boston, MA 02114, USA
    East Afr Med J 85:442-9. 2008
    ..To evaluate the performance of QuantiFERON-TB GOLD (QFTG) in a resource-poor setting among patients with and without HIV infection...
  90. ncbi Risk factors associated with tuberculin skin test positivity among university students and the use of such factors in the development of a targeted screening program
    Venkatarama Rao Koppaka
    Division of Tuberculosis Control, Virginia Department of Health, Richmond, VA, USA
    Clin Infect Dis 36:599-607. 2003
    ..6%, a specificity of 91.0%, and positive and negative predictive values of 17.7% and 99.5%, respectively. Risk assessment can be an accurate means of identifying candidates for tuberculin screening...
  91. doi Preventing tuberculosis flare in patients with inflammatory rheumatic diseases receiving tumor necrosis factor-alpha inhibitors in India -- An audit report
    Anand N Malaviya
    Joint Disease Clinic, Indian Spinal Injuries Centre Superspeciality Hospital and Clinic for Arthritis and Rheumatism, New Delhi, India
    J Rheumatol 36:1414-20. 2009
    ..To test the efficacies of a strategy for preventing tuberculosis (TB) in Indian patients with inflammatory rheumatic diseases (IRD) treated with tumor necrosis factor-alpha (TNF-alpha) inhibitor...
  92. pmc Role of interferon gamma release assay in active TB diagnosis among HIV infected individuals
    Basirudeen Syed Ahamed Kabeer
    Department of Immunology, Tuberculosis Research Centre ICMR, Tamil Nadu, India
    PLoS ONE 4:e5718. 2009
    ..In this study, we assessed the sensitivity of Interferon gamma release assay (IGRA) in active tuberculosis patients who were positive for HIV infection and compared it with that of tuberculin skin test (TST)...
  93. doi T cells co-producing Mycobacterium tuberculosis-specific type 1 cytokines for the diagnosis of latent tuberculosis
    Johannes Nemeth
    Department of Internal Medicine I, Division of Infectious Diseases, Medical University of Vienna, Austria
    Eur Cytokine Netw 21:34-9. 2010
    ..82). This suggests that the enumeration of MTB-specific CD4+ T cells might introduce greater specificity for the diagnosis of latent TB, compared to the TST...
  94. pmc Interpreting tuberculin skin tests in a population with a high prevalence of HIV, tuberculosis, and nonspecific tuberculin sensitivity
    Peter J Dodd
    Department of Infectious Disease Epidemiology, St Mary s Medical School, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Am J Epidemiol 171:1037-45. 2010
    ..However, the optimal cutpoint for HIV-infected individuals was consistently 0 mm. This calibration method may provide a valuable tool for interpreting TST results in other populations...
  95. pmc Strengths and weaknesses of diagnostic tools for tuberculous uveitis
    Daniel V Vasconcelos-Santos
    Doheny Eye Institute, University of Southern California, Los Angeles, CA 90033, USA
    Ocul Immunol Inflamm 17:351-5. 2009
    ..This article critically analyzes the role of these tests in supporting the diagnosis of tuberculous uveitis and proposes a practical diagnostic approach, based on a judicious combination of these tests...
  96. pmc Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, Department of Medicine, University of Cape Town
    S Afr Med J 99:738-43. 2009
    ..While adult TB results from both recent and past infection, childhood TB results from recent infection and reflects ongoing transmission despite current TB control strategies...
  97. pmc IFNgamma response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia
    Helena del Corral
    Grupo de Epidemiologia, Universidad de Antioquia, Medellin, Colombia
    PLoS ONE 4:e8257. 2009
    ..We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFNgamma levels in HHCs correlate with tuberculosis development...
  98. ncbi Use of the QuantiFERON-TB Gold test for screening tuberculosis contacts and predicting active disease
    T Yoshiyama
    First Clinical Department, Fukujuji Hospital, Tokyo, Japan
    Int J Tuberc Lung Dis 14:819-27. 2010
    ..To evaluate the performance of the QuantiFERON(R)-TB Gold (QFT-G) test for screening tuberculosis (TB) contacts and estimating their risk of progressing to active TB disease...
  99. ncbi Epidemiology and diagnosis of Mycobacterium tuberculosis in captive Asian elephants (Elephas maximus)
    S K Mikota
    Audubon Center for Research of Endangered Species, 14001 River Road, New Orleans, Louisiana 70131, USA
    J Zoo Wildl Med 32:1-16. 2001
    ..The intradermal tuberculin test, enzyme-linked immunosorbent assay serology, the blood tuberculosis test, and nucleic acid amplification and ..
  100. doi Risk-based screening for latent tuberculosis infection
    Connie A Haley
    Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Nashville, Tennessee, USA
    South Med J 101:142-9. 2008
    ..National guidelines recommend targeted tuberculin testing and treatment of latent tuberculosis infection (LTBI) among high-risk groups but discourage testing low-risk persons...
  101. pmc An improved whole-blood gamma interferon assay based on the CFP21-MPT64 fusion protein
    Ruiling Fu
    Department of Pathogen Biology, Laboratory of Bio Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Clin Vaccine Immunol 16:686-91. 2009
    ..3% (k = 0.64); rCM-WBIA positivity was associated with a larger TST induration. These results suggest that rCM-WBIA, based on the recombinant fusion protein CFP21-MPT64, is a promising alternative diagnostic tool for detection of LTBI...

Research Grants71

  1. Epidemiologic Strategies for Tuberculosis Control
    Jonathan Golub; Fiscal Year: 2007
    ..This K01 award will provide the epidemiological training and experience necessary to become a successful, independent public health investigator. ..
  2. Mentoring in Tuberculosis Patient-Oriented Research
    Neil Schluger; Fiscal Year: 2007
    ..abstract_text> ..
  3. Training in Translational Lung Research
    Neil Schluger; Fiscal Year: 2007
    ..abstract_text> ..
  4. The Utility of Interferon-Gamma Release Assays in TB-HIV co-infected Children
    Anna M Mandalakas; Fiscal Year: 2010
    ..However, it is imperative that the utility and interpretation of these tests be studied in HIV-infected children in settings with high burdens of TB and HIV. ..
  5. NATURAL HISTORY OF HEPATITIS C INFECTION IN HIV DISEASE
    C Horsburgh; Fiscal Year: 2003
    ..These studies are expected to improve our understanding of the natural history and pathogenesis of HCV in immunosuppressed hosts. ..
  6. BU Clinical HIV/AIDS Research Training Program
    C Horsburgh; Fiscal Year: 2007
    ..This will prepare trainees for success in future independent clinical research careers. ..
  7. Partners in Health and Housing Prevention Research Cent*
    C Horsburgh; Fiscal Year: 2007
    ..Abstract not provided ..
  8. NATURAL HISTORY OF HEPATITIS C INFECTION IN HIV DISEASE
    C Horsburgh; Fiscal Year: 2006
    ..These investigations will define the role of HIV infection in progression of HCV disease and guide HCV treatment and prevention strategies for IDU. ..
  9. Immunoepidemiology of Concomittant Infection
    Sharon Perry; Fiscal Year: 2007
    ..S. foreign born and the developing world. ..
  10. Mechanisms of Regulatory T cell Suppression of HIV-specific Cellular Immunity
    Timothy Lahey; Fiscal Year: 2007
    ..Thus, this proposal will support a promising young investigator who seeks to broaden his skill set as a clinician-scientist while determining how regulatory T cells weaken cellular immune responses against HIV. ..
  11. DENVER COMMUNITY PROGRAM FOR CLINICAL RESEARCH ON AIDS (
    David Cohn; Fiscal Year: 2007
    ..abstract_text> ..
  12. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2007
    ....
  13. SURFACTANT PROTEINS AND RESPIRATORY DISTRESS SYNDROME
    Joanna Floros; Fiscal Year: 2009
    ....
  14. Longitudinal Study of Maternal HIV on their Late Adolescent/Early Adult Children
    Debra Murphy; Fiscal Year: 2009
    ..This would be the first cohort of children affected by maternal HIV/AIDS followed all the way from early school age through late adolescence/early adulthood, allowing investigation of long-term outcomes of these children. ..
  15. Regulation of IFN-gamma production in human tuberculosis
    Peter Barnes; Fiscal Year: 2009
    ..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..
  16. An HB Vaccine Model For HIV Vaccine Trials in Drug Users
    Lu Yu Hwang; Fiscal Year: 2007
    ..abstract_text> ..
  17. Maternal HIV: Intervention to Assist Disclosure to Children
    Debra Murphy; Fiscal Year: 2009
    ..Few interventions, other than for prevention or medication adherence, are available for women living with HIV; this study will evaluate an intervention that will help HIV-positive mothers deal with a serious family issue. ..
  18. The Effect of a School Based Hand Sanitizer Program on Asthma
    Lynn Gerald; Fiscal Year: 2007
    ..By achieving these specific aims, this study will provide valuable information on the effectiveness of hand sanitizers in the school setting. ..
  19. Regulation of IFN-gamma production in human tuberculosis
    Peter Barnes; Fiscal Year: 2007
    ..CREB/ATF/AP-1 levels in T-cells of tuberculosis patients will be enhanced by viral expression vectors and nucleofection, and the effects on IFN-gamma production will be determined. ..
  20. Impaired Glucose Metabolism in HIV-Infected Drug Users
    Andrea Howard; Fiscal Year: 2007
    ..She will also complete coursework in the conduct of diabetes-related clinical research, addiction medicine, and the responsible conduct of research. ..
  21. YOUNG AIDS ORPHANS--PROSPECTIVE BEREAVEMENT
    Debra Murphy; Fiscal Year: 2002
    ..Additionally, evaluation of children's long-term adjustment (mental health, behavioral, and social outcomes), will assist in detemining resiliency factors and risk factors for children who are orphaned by ADS. ..
  22. MEDICATION ADHERENCE INTERVENTION FOR HIV+ PERSONS
    Debra Murphy; Fiscal Year: 2002
    ....
  23. EVALUATION OF ADOPTIVE T CELL THERAPY FOR HIV
    DEBORAH LEWINSOHN; Fiscal Year: 2002
    ..My long-term goal is to work in an academic medical center as a physician scientist with a primary focus on the immunopathogenesis of HIV infection. ..
  24. OZONE EFFECTS ON FUNCTION OF SURFACTANT PROTEIN VARIANTS
    Joanna Floros; Fiscal Year: 2001
    ....
  25. CANCER AWARENESS NETWORK FOR IMMIGRANT MINORITY POPULATI
    Francesca Gany; Fiscal Year: 2004
    ..abstract_text> ..
  26. Tuberculosis Immunity in Young Children
    DEBORAH LEWINSOHN; Fiscal Year: 2006
    ..These studies may contribute to a more complete understanding of TB immunity in young children, and hence 'facilitate the development of an improved TB vaccine for this vulnerable population. ..
  27. The Role of surfactant protein genetic variants in cyst*
    Joanna Floros; Fiscal Year: 2005
    ..aeruginosa and its clearance, and provide the basis for further consideration of novel therapeutic strategies to treat CF-related lung disease. ..
  28. A Parenting Intervention for HIV+ Moms: The IMAGE program
    Debra A Murphy; Fiscal Year: 2010
    ....
  29. Comparison of Risk Factors for SIDS and Other Sudden Unexpected Deaths in Infancy
    FERN HAUCK; Fiscal Year: 2007
    ....
  30. Tuberculosis Immunity in Young Children
    DEBORAH LEWINSOHN; Fiscal Year: 2005
    ..These studies may contribute to a more complete understanding of TB immunity in young children, and hence facilitate the development of an improved TB vaccine for this vulnerable population. ..
  31. TNF and Granuloma Formation in Tuberculosis
    PHILANA LIN; Fiscal Year: 2007
    ..These changes will be analyzed the context of granuloma structure and host response to infection. The University of Pittsburgh provides an ideal research environment to support this training program. ..