forced expiratory volume

Summary

Summary: Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.

Top Publications

  1. doi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
  2. doi Changes in forced expiratory volume in 1 second over time in COPD
    Jørgen Vestbo
    Respiratory Section, Hvidovre Hospital, Hvidovre, Denmark
    N Engl J Med 365:1184-92. 2011
  3. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
  4. doi Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
  5. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
  6. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  7. doi Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society
    Amir Qaseem
    American College of Physicians and Temple University, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 155:179-91. 2011
  8. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
  9. doi Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium
    James F Donohue
    University of North Carolina, 4125 Bioinformatics Building, 130 Mason Farm Road, CB 7020, Chapel Hill, NC, USA
    Am J Respir Crit Care Med 182:155-62. 2010
  10. doi Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
    Denis E O'Donnell
    Queen s University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Respir Med 105:1030-6. 2011

Detail Information

Publications241 found, 100 shown here

  1. doi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  2. doi Changes in forced expiratory volume in 1 second over time in COPD
    Jørgen Vestbo
    Respiratory Section, Hvidovre Hospital, Hvidovre, Denmark
    N Engl J Med 365:1184-92. 2011
    A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established ..
  3. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
    ..Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD...
  4. doi Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
    ..We have much yet to learn, but establishing a common language for future research will facilitate our understanding and management of the complexity implicit to this disease...
  5. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  6. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  7. doi Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society
    Amir Qaseem
    American College of Physicians and Temple University, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 155:179-91. 2011
    ....
  8. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
    ..We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow ..
  9. doi Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium
    James F Donohue
    University of North Carolina, 4125 Bioinformatics Building, 130 Mason Farm Road, CB 7020, Chapel Hill, NC, USA
    Am J Respir Crit Care Med 182:155-62. 2010
    ..Indacaterol is the first once-daily, long-acting inhaled beta(2)-agonist bronchodilator studied in patients with chronic obstructive pulmonary disease (COPD)...
  10. doi Effect of indacaterol on exercise endurance and lung hyperinflation in COPD
    Denis E O'Donnell
    Queen s University and Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
    Respir Med 105:1030-6. 2011
    ..This study investigated the effect of indacaterol on exercise endurance, and on lung hyperinflation during exercise and at rest in patients with moderate-to-severe COPD...
  11. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = ..
  12. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    The ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC) is a measure used to diagnose airflow obstruction and is highly heritable...
  13. doi The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort
    Ciro Casanova
    Pulmonary Department, Hospital Universitario La Candelaria, Tenerife, Spain
    Am J Respir Crit Care Med 184:1015-21. 2011
    ..Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and progressive loss of lung function usually expressed as mean values for whole cohorts...
  14. doi Effect of indacaterol on dynamic lung hyperinflation and breathlessness in hyperinflated patients with COPD
    Kai Michael Beeh
    insaf Respiratory Research Institute, D 65187 Wiesbaden, Germany
    COPD 8:340-5. 2011
    ..Patients (40-80 years) with post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 70%, percent predicted FEV1 ≥ 40% and ≤ 80%, smoking ..
  15. ncbi Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
    Peter M A Calverley
    School of Clinical Sciences, Liverpool, UK
    Lancet 374:685-94. 2009
    ..We therefore investigated whether roflumilast would reduce the frequency of exacerbations requiring corticosteroids in patients with COPD...
  16. ncbi Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD
    Ronald Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    Thorax 65:473-9. 2010
    ..In previous studies, indacaterol provided 24 h bronchodilation on once-daily dosing with a fast onset of action. This study compared the efficacy and safety of indacaterol with the twice-daily LABA formoterol and placebo over 1 year...
  17. ncbi QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease
    Jan A van Noord
    Department of Respiratory Diseases, Atrium Medisch Centrum, Heerlen, The Netherlands
    Thorax 65:1086-91. 2010
    ....
  18. doi Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
    Marc Decramer
    Respiratory Division, University of Leuven, Leuven, Belgium
    Lancet 374:1171-8. 2009
    ..However, there are few data for treatment in the early stages of the disease. We examined the effect of tiotropium on outcomes in a large subgroup of patients with moderate COPD...
  19. pmc Profiling serum biomarkers in patients with COPD: associations with clinical parameters
    Victor Pinto-Plata
    Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, Massachusetts 02135, USA
    Thorax 62:595-601. 2007
    ..A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology...
  20. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  21. ncbi Screening for and early detection of chronic obstructive pulmonary disease
    Joan B Soriano
    CIMERA International Center for Advanced Respiratory Medicine, Recinte Hospital Joan March, Bunyola, Spain
    Lancet 374:721-32. 2009
    ..All in all, spirometry is recognised as the essential test for diagnosis and monitoring of COPD...
  22. ncbi TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    N C Arbour
    1 Department of Medicine, Department of Veterans Affairs Medical Center, The University of Iowa, Iowa City, Iowa, USA
    Nat Genet 25:187-91. 2000
    ....
  23. ncbi Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers
    J A Hardie
    Institute of Internal Medicine, Deaconess Hospital, University of Bergen, Norway
    Eur Respir J 20:1117-22. 2002
    ..Obstructive Lung Disease (GOLD) has defined stage I chronic obstructive pulmonary disease (COPD) as forced expiratory volume in one second/forced vital capacity (FEV1/FVC)% <70% and a FEV1% predicted of >80%...
  24. doi Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease
    Masaharu Nishimura
    First Department of Medicine, Hokkaido University School of Medicine, and Center for Respiratory Diseases, Hokkaido Social Insurance Hospital, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Am J Respir Crit Care Med 185:44-52. 2012
    ..Although the rate of annual decline in FEV1 is one of the most important outcome measures in chronic obstructive pulmonary disease (COPD), little is known about intersubject variability based on clinical phenotypes...
  25. pmc Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD
    R A O'Donnell
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 59:837-42. 2004
    ..A number of research tools have been combined to study smokers with a range of COPD severities classified according to the GOLD criteria...
  26. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    ..The aim of this study was to investigate whether these are related...
  27. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..Our study showed a close link between smoking and expression of TGF-beta1 in small airways. Our results also suggested that small airway epithelial cells might be involved in obstructive changes found in smokers and patients with COPD...
  28. doi The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort
    Robab Kohansal
    Epidemiology and Clinical Research, Fundación Caubet CIMERA Illes Balears, Recinte Hospital Joan March, 07110 Bunyola, Illes Balears, Spain
    Am J Respir Crit Care Med 180:3-10. 2009
    ..Understanding normal lung development and aging in health and disease, both in men and in women, is essential to interpreting any therapeutic intervention...
  29. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
    ..However, there are only limited data about the influence of GOLD severity staging on the effectiveness of SFC, particularly in patients with milder disease...
  30. pmc Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial
    Stephen I Rennard
    Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    Drugs 69:549-65. 2009
    ....
  31. pmc Associations of IL6 polymorphisms with lung function decline and COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Thorax 64:698-704. 2009
    ..There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers...
  32. ncbi The effects of body mass index on lung volumes
    Richard L Jones
    Pulmonary Division, University of Alberta, Edmonton, AB, Canada T6G 2B7
    Chest 130:827-33. 2006
    ..It is well known that obesity causes decreases in lung volumes, but there has never been a large study showing the correlation between body mass index (BMI) and the various lung volumes...
  33. ncbi Systemic inflammation and COPD: the Framingham Heart Study
    Robert E Walter
    Section of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Chest 133:19-25. 2008
    ..We examined the hypothesis that systemic inflammatory biomarkers are associated with impaired lung function, particularly among those with extensive cigarette smoking...
  34. ncbi Pulmonary function and abdominal adiposity in the general population
    Heather M Ochs-Balcom
    INFORMA, National Cancer Institute Regina Elena, Rome, Via Elio Chianesi 53, 00144 Rome, Italy
    Chest 129:853-62. 2006
    ..The mechanism for this association and the best marker of abdominal adiposity in relation to pulmonary function is not known...
  35. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..A physiological variable--the forced expiratory volume in one second (FEV1)--is often used to grade the severity of COPD...
  36. ncbi Prediction equations for normal and low lung function from the Health Survey for England
    E Falaschetti
    Dept of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Eur Respir J 23:456-63. 2004
    ..The measurements used were the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) of a sample of 6,053 "healthy" (nonsmokers with no ..
  37. doi Efficacy and tolerability of indacaterol 75 μg once daily in patients aged ≥40 years with chronic obstructive pulmonary disease: results from 2 double-blind, placebo-controlled 12-week studies
    Edward M Kerwin
    Clinical Research Institute of Southern Oregon PC, Medford, Oregon 97504, USA
    Clin Ther 33:1974-84. 2011
    ....
  38. ncbi Sustained 24-h efficacy of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients
    C Verkindre
    Hopital de Bethune, Beuvry, France
    Respir Med 104:1482-9. 2010
    ..All doses of NVA237 and tiotropium were well tolerated. NVA237 once-daily was effective and well tolerated versus placebo, and demonstrated rapid and sustained 24-h bronchodilation. (ClinicalTrials.gov Identifier: NCT00501852)...
  39. ncbi Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease
    M Dahl
    Department of Clinical Biochemistry, Herlev and Copenhagen University Hospitals, Copenhagen, Denmark
    Am J Respir Crit Care Med 164:1008-11. 2001
    ..We measured plasma fibrinogen and forced expiratory volume in 1 s (FEV(1)), and assessed prospectively COPD hospitalizations in 8,955 adults from the Danish general ..
  40. doi Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis
    Kaïssa de Boer
    The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Thorax 66:680-5. 2011
    ..The aim of this study was to determine if frequent pulmonary exacerbations are associated with greater declines in lung function, or an accelerated time to death or lung transplantation in adults with CF...
  41. doi Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study
    Claus Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg Baldingerstrasse, D 35043 Marburg, Germany
    Respir Med 102:1511-20. 2008
    ..Combined bronchodilator therapy may be a valuable treatment option for patients with COPD...
  42. ncbi Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD...
  43. ncbi Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects
    Yue Chen
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada
    Am J Clin Nutr 85:35-9. 2007
    ..Because both weight and height are indicators of body size, body mass index (BMI) may not be an ideal index of obesity in prediction of pulmonary dysfunction...
  44. ncbi Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis
    H C Selvadurai
    Children s Chest Research Centre and Department of Respiratory Medicine, Royal Alexandra Hospital for Children, New South Wales, Australia
    Pediatr Pulmonol 33:194-200. 2002
    ..A combination of aerobic and resistance training may be the best training program, and future studies to assess optimal training programs for CF patients are indicated...
  45. pmc Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology
    Ravi S Aysola
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Chest 134:1183-91. 2008
    ..To prospectively apply an automated, quantitative three-dimensional approach to imaging and airway analysis to assess airway remodeling in asthma patients...
  46. ncbi Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  47. ncbi Obesity is a risk factor for dyspnea but not for airflow obstruction
    Don D Sin
    Department of Medicine, University of Alberta, Edmonton, Canada T6G 2B7
    Arch Intern Med 162:1477-81. 2002
    ..However, since obesity can cause dyspnea through mechanisms other than airflow obstruction, diagnostic misclassification of asthma could partially account for this association...
  48. ncbi Airway and systemic inflammation and decline in lung function in patients with COPD
    Gavin C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London Hospital School of Medicine and Dentistry, London, UK
    Chest 128:1995-2004. 2005
    ..Patients with COPD experience lower airway and systemic inflammation, and an accelerated decline in FEV1. There is no evidence on whether this inflammation changes over time, or if it is associated with a faster decline in FEV1...
  49. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  50. ncbi Are patients with COPD more active after pulmonary rehabilitation?
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Chest 134:273-80. 2008
    ..Despite a variety of benefits brought by pulmonary rehabilitation to patients with COPD, it is unclear whether these patients are more active during daily life after the program...
  51. doi Quantitative assessment of emphysema, air trapping, and airway thickening on computed tomography
    Young Kyung Lee
    Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Research Institute of Radiology, 388 1, Pungnap dong, Songpa Ku, Seoul 138 736, Korea
    Lung 186:157-65. 2008
    ..563, p<0.001). MLD(exp) showed the strongest correlation with the BODE index (R= -0.756, p<0.001). We conclude that the severity of emphysema and air trapping measured on CT correlated with the PFT parameters 6MWD and BMI...
  52. pmc Physical inactivity in patients with COPD, a controlled multi-center pilot-study
    Thierry Troosters
    Pulmonary Rehabilitation and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium
    Respir Med 104:1005-11. 2010
    ..Studies in moderate COPD are currently scarce. The aim of the present study was to investigate physical activity in daily life in patients with COPD (n=70) and controls (n=30)...
  53. ncbi Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD
    Tom M A Wilkinson
    Academic Unit of Respiratory Medicine, St Bartholomew s and The Royal London School of Medicine, St Bartholomew s Hospital, London, UK
    Chest 129:317-24. 2006
    ....
  54. doi Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD
    Francois Maltais
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, 2725 Chemin Sainte Foy, Quebec G1V 4G5, Canada
    Respir Med 105:580-7. 2011
    ..Static and dynamic lung hyperinflation are associated with exercise impairment and poor outcomes in COPD patients. Aclidinium bromide is a novel, long-acting inhaled muscarinic antagonist currently in development for COPD treatment...
  55. doi Bronchodilator responsiveness in patients with COPD
    D P Tashkin
    David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA
    Eur Respir J 31:742-50. 2008
    ..Spirometry was performed before and 90 min following ipratropium administration. The criteria used for forced expiratory volume in one second (FEV(1)) responsiveness were: >or=12% increase over baseline and >or=200 mL; >or=..
  56. ncbi How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease?
    Kjetil Herland
    Department of Community Medicine and General Practice, NTNU, Trondheim, Norway
    Respir Med 99:11-9. 2005
    ..It is questionable whether such data can extrapolated to a larger, "real life" population of patients with obstructive lung disease. Moreover, we found surprisingly minor differences between the Specialist and GP populations...
  57. ncbi Dynamic hyperinflation with bronchoconstriction: differences between obese and nonobese women with asthma
    Tim J T Sutherland
    Respiratory Research Unit, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 177:970-5. 2008
    ..It is unclear whether the dynamic changes that occur during bronchoconstriction differ between obese versus nonobese patients with asthma...
  58. pmc Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry
    Liam G Heaney
    Centre for Infection and Immunity, Queen s University of Belfast, Level 8, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, UK
    Thorax 65:787-94. 2010
    ....
  59. ncbi Indacaterol once-daily is equally effective dosed in the evening or morning in COPD
    H Magnussen
    Pulmonary Research Institute, Hospital Grosshansdorf, Grosshansdorf, Germany
    Respir Med 104:1869-76. 2010
    ..05); and the % of days able to perform usual activities (by 6.7 and 7.8 points; p < 0.05). Indacaterol provided 24-h bronchodilation and improvement in symptoms regardless of whether taken regularly in the morning or evening...
  60. ncbi Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trøndelag Study
    A Langhammer
    , The Norwegian University of Science and Technology (NTNU, Verdal
    Eur Respir J 18:770-9. 2001
    ..After a plateau in younger adults, the variables declined by age. The reference values for forced expiratory volume in one second and forced vital capacity from the present study, were higher than those given by ..
  61. pmc Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study
    Emily S Wan
    Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 184:57-63. 2011
    ..These smokers are a poorly characterized group due to their systematic exclusion from chronic obstructive pulmonary disease (COPD) studies...
  62. doi Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients
    R M Mroz
    Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland
    Adv Exp Med Biol 756:23-8. 2013
    ..The patients' quality of life also changed favorably in the indacaterol treatment arm. We conclude that the add-on therapy with indacaterol exerts positive effects in COPD patients...
  63. pmc Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation
    Sue R Downie
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    Thorax 62:684-9. 2007
    ....
  64. pmc Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD
    Jennifer K Quint
    Academic Unit of Respiratory Medicine, University College London, Rowland Hill St, London NW3 2PF, England
    Chest 137:812-22. 2010
    ....
  65. pmc Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches
    Didier Renard
    Novartis Pharma AG, Basel, Switzerland
    Respir Res 12:54. 2011
    ..The large inter-patient and inter-study variability in forced expiratory volume in 1 second (FEV1) with bronchodilators makes determination of optimal doses difficult in conventional ..
  66. ncbi Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 158:1557-65. 1998
    ..35, p < 0.001). We concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD...
  67. pmc Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica
    John M Brehm
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:765-71. 2009
    ..Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood...
  68. ncbi What have we learned from large drug treatment trials in COPD?
    Peter M A Calverley
    Division of Infection and Immunity, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 370:774-85. 2007
    ..Ensuring that these expensive studies are done objectively to the highest standard is an important goal for the next decade...
  69. pmc Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies
    Eric Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Int J Chron Obstruct Pulmon Dis 5:197-208. 2010
    ..Tiotropium Respimat SMI 5 microg demonstrated sustained improvements in patients with COPD relative to placebo and similar to the 10 microg dose but with a lower frequency of anticholinergic adverse events...
  70. ncbi Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma
    Florence N Schleich
    Department of Pulmonary Medicine, CHU Sart Tilman, Liege, I GIGA Research Group, University of Liege, Belgium
    Thorax 65:1039-44. 2010
    ..However, the FeNO threshold value that identifies a sputum eosinophil count ≥3% in an unselected population of patients with asthma has been poorly studied...
  71. pmc Percent emphysema, airflow obstruction, and impaired left ventricular filling
    R Graham Barr
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 362:217-27. 2010
    ....
  72. doi Severe exacerbations and decline in lung function in asthma
    Paul M O'Byrne
    Department of Medicine, McMaster University Medical Center, Ontario, Canada
    Am J Respir Crit Care Med 179:19-24. 2009
    ..To evaluate the association between asthma exacerbations and the decline in lung function, as well as the potential effects of an inhaled corticosteroid, budesonide, on exacerbation-related decline in patients with asthma...
  73. doi Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)
    J Vestbo
    Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Eur Respir J 31:869-73. 2008
    Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and not well understood. The forced expiratory volume in one second is used for the diagnosis and staging of COPD, but there is wide acceptance that it is a crude ..
  74. doi Aclidinium bromide provides long-acting bronchodilation in patients with COPD
    P Chanez
    Universite de la Mediterranee, Departement des Maladies Respiratoires, AP HM, 270 Boulevard de Sainte Marguerite, F 13009 Marseille, France
    Pulm Pharmacol Ther 23:15-21. 2010
    ..Aclidinium produced sustained bronchodilation over 24h and was well tolerated during this short-term study. Based on these data, aclidinium 200microg was selected as the investigational dose for future clinical trials in COPD...
  75. pmc Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
    J J Soler-Cataluña
    Unidad de Neumología, Servicio de Medicina Interna, Hospital General de Requena, Paraje Casablanca s n 46340, Requena Valencia, Spain
    Thorax 60:925-31. 2005
    ..However, little is known about the prognostic consequences of these exacerbations. A study was undertaken to investigate whether severe acute exacerbations of COPD exert a direct effect on mortality...
  76. doi Primary care spirometry
    E Derom
    Dept of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur Respir J 31:197-203. 2008
    ..The precision of the forced vital capacity measurements could be improved in some of the available models...
  77. pmc Effect on smoking quit rate of telling patients their lung age: the Step2quit randomised controlled trial
    Gary Parkes
    The Limes Surgery, Hoddesdon, Hertfordshire EN11 8EP
    BMJ 336:598-600. 2008
    ..To evaluate the impact of telling patients their estimated spirometric lung age as an incentive to quit smoking...
  78. pmc Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    Diana C Grootendorst
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Thorax 62:1081-7. 2007
    ..Results from in vitro studies with roflumilast indicate that it has anti-inflammatory properties that may be applicable for the treatment of COPD...
  79. ncbi BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
    Talmadge E King
    Department of Medicine, UCSF, 505 Parnassus Avenue, Room M994, San Francisco, CA 94110, USA
    Am J Respir Crit Care Med 177:75-81. 2008
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease lacking effective treatment...
  80. pmc Association between self-reported childhood socioeconomic position and adult lung function: findings from the British Women's Heart and Health Study
    D A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Thorax 59:199-203. 2004
    ..A study was undertaken to assess the associations between indicators of early life socioeconomic position and lung function in older adulthood...
  81. ncbi The efficacy and safety of combination salmeterol (50 microg)/fluticasone propionate (500 microg) inhalation twice daily via accuhaler in Chinese patients with COPD
    Jin ping Zheng
    Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, People s Republic of China
    Chest 132:1756-63. 2007
    ....
  82. ncbi Asthma control during the year after bronchial thermoplasty
    Gerard Cox
    St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    N Engl J Med 356:1327-37. 2007
    ..Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma...
  83. pmc Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: cross sectional case finding study
    C P van Schayck
    Department of General Practice, Research Institute ExTra, University of Maastricht, Postbox 616, 6200 MD Maastricht, Netherlands
    BMJ 324:1370. 2002
    ..To investigate the effectiveness of case finding of patients at risk of developing chronic obstructive pulmonary disease, whether the method is suitable for use in general practice, how patients should be selected, and the time required...
  84. ncbi Early emphysema in patients with anorexia nervosa
    Harvey O Coxson
    Department of Radiology, Vancouver Coastal Health Research Institute Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
    Am J Respir Crit Care Med 170:748-52. 2004
    ..These data demonstrate that emphysema-like changes are present in the lungs of patients who are chronically malnourished...
  85. ncbi Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study
    June H Lee
    Genentech, Inc, 1 DNA Way, MS 453B, South San Francisco, CA 94080, USA
    Chest 132:1882-9. 2007
    ..A better understanding is needed regarding factors associated with persistent airway obstruction; this study was performed to determine demographic and clinical characteristics associated with persistent airflow limitation...
  86. doi Quantification of the impact of segmentectomy on pulmonary function by perfusion single-photon-emission computed tomography and multidetector computed tomography
    Kentaro Yoshimoto
    Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Thorac Cardiovasc Surg 137:1200-5. 2009
    ..The impact of segmentectomy for preservation of pulmonary function was quantified by using a co-registered perfusion single-photon-emission computed tomography and multidetector computed tomography (SPECT/CT)...
  87. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  88. doi Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD
    Khaled Al-shair
    Medicines Evaluation Unit, North West Lung Research Centre, Langley Building, Southmoor Road, The University of Manchester, South Manchester University Hospitals Trust, Wythenshawe, Manchester M23 9QZ, UK
    Respir Med 103:1572-9. 2009
    ..We aimed to assess depression using 2 different depression scales and to examine the association between depression and poor exercise performance, BODE index and muscle wasting in clinically stable COPD patients...
  89. ncbi Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone
    Angelo M Taveira-Dasilva
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 6D 05, MSC 1590, Bethesda, MD 20892 1590, USA
    Chest 126:1867-74. 2004
    ..Hence, hormonal therapy with progesterone is frequently employed; however, efficacy has not been demonstrated. Our aim was to determine whether progesterone administration slowed the decline in lung function in LAM...
  90. pmc Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials
    Laura B Herpel
    The Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 173:1106-13. 2006
    ..This may be applied to determine criteria that can be used to assess a clinically meaningful change in spirometry...
  91. pmc The ratio of FEV1 to FVC as a basis for establishing chronic obstructive pulmonary disease
    Carlos A Vaz Fragoso
    Yale Claude D Pepper Older Americans Independence Center, New Haven, Connecticut, USA
    Am J Respir Crit Care Med 181:446-51. 2010
    ..The clinical validity of this threshold as a basis for establishing chronic obstructive pulmonary disease is unknown...
  92. ncbi Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III
    A L P Albuquerque
    Pulmonary Function and Clinical Exercise Physiology Unit, Respiratory Division, Dept of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
    Eur Respir J 28:939-44. 2006
    ..study, a comparison was made of the individual performance of post-bronchodilator IC, IC/TLC and forced expiratory volume in one second (FEV(1)) in predicting a severely reduced peak oxygen uptake (V'(O(2)); <60% predicted) ..
  93. ncbi Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease
    Yuji Higashimoto
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, 377 2 Ohnohigashi, Osakasayama, Osaka, 589 8511 Japan
    Respir Med 103:1231-8. 2009
    ..We examined correlations between serum biomarkers and the decline of lung function in COPD patients...
  94. ncbi Concentration of matrix metalloproteinase-9 in serum of patients with chronic obstructive pulmonary disease and a degree of airway obstruction and disease progression
    B Brajer
    Department of Pulmonary Diseases, Poznan University of Medical Sciences, Poznan, Poland
    J Physiol Pharmacol 59:145-52. 2008
    ..01) and FEV1/FVC (P=0.0002). In conclusion, the results suggest that MMP-9 plays an important role in systemic inflammation in COPD. Higher MMP-9 serum concentration is connected with higher airway obstruction and disease progression...
  95. ncbi Prediction of pulmonary function after lung lobectomy by subsegments counting, computed tomography, single photon emission computed tomography and computed tomography: a comparative study
    Kentaro Yoshimoto
    Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Eur J Cardiothorac Surg 35:408-13. 2009
    ..The aim of the present study was to determine the optimal method of predicting postoperative pulmonary function (PPF) after lung lobectomy...
  96. doi Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
    E J Hothersall
    Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Thorax 63:1070-5. 2008
    ..A study was undertaken to test the hypothesis that atorvastatin added to inhaled corticosteroids improves lung function and airway inflammation in atopic adults with asthma...
  97. ncbi The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
    ..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
  98. ncbi Lifecourse predictors of adult respiratory function: results from the Newcastle Thousand Families Study
    P W G Tennant
    Sir James Spence Institute, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Thorax 63:823-30. 2008
    ..We have used detailed longitudinal data from the Newcastle Thousand Families cohort to assess the impact of birth weight, and various other factors acting throughout the lifecourse, on predicting forced expiratory volume in 1 s (FEV(1)).
  99. pmc Systemic and bronchodilator effects of inhaled rac-formoterol in subjects with chronic obstructive pulmonary disease: a dose-response study
    Christopher I Whale
    Division of Respiratory Medicine, University of Nottingham, City Hospital, Nottingham, UK
    Br J Clin Pharmacol 65:841-7. 2008
    ..There are concerns with the overall safety of high-dose beta(2)-agonists in subjects with COPD, and this study looks at the balance of beneficial and adverse effects of a range of doses of inhaled formoterol...
  100. ncbi Severe exacerbations predict excess lung function decline in asthma
    T R Bai
    Respiratory Division, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Respir J 30:452-6. 2007
    ..these variables, asthma patients with frequent exacerbations had a significantly larger annual decline in forced expiratory volume in one second (FEV(1); median difference (95% confidence interval) 16.9 (1.5-32.2) mL.yr(-1))...
  101. ncbi A one-year trial of tiotropium Respimat plus usual therapy in COPD patients
    E D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Mowbray, Cape Town, South Africa
    Respir Med 104:1460-72. 2010
    ..The protocol is registered on the European Clinical Trials Database as trial number 2006-001009-27 and in the ClinicalTrials.gov database as NCT00387088...

Research Grants78

  1. Indoor woodsmoke PM and asthma: a randomized trial
    Anthony Ward; Fiscal Year: 2009
    ..outcomes measured prior to and following the intervention will include peak expiratory flow (PEF) and forced expiratory volume in first second (FEV1), biomarkers in exhaled breath condensate (i.e...
  2. INVESTIGATION OF A POSSIBLE ASSOCIATION BETWEEN MYCOPLASMA SPECIES AND ASTHMA
    Richard Martin; Fiscal Year: 1999
    ..02). Analysis of the treatment arm of the protocol revealed an improvement in the percentage predicted forced expiratory volume in one second (FEV1) from 2.65 1 0.12 L to 2.73 1 0.11 L (p=0.015) in the clarithromycin treated group...
  3. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
    ..indoor allergen) and airway limitation by objective pulmonary function testing (a 12-15% change in forced expiratory volume in one second (FEV-1)...
  4. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ..asked to complete a daily dyspnea questionnaire and perform bedside pyrometer (forced vital capacity and forced expiratory volume in the 1st sec) on three consecutive days; b-type natriuretic peptide (BNP) will be analyzed at study ..
  5. Environmental Effects on Lung Function in Cystic Fibrosis Patients
    Christopher Goss; Fiscal Year: 2007
    ..We also found that for every increase in PM2.5 of 10 [unreadable]g/m3, there was an associated fall in forced expiratory volume in 1 second (FEV1) of 24 ml (7 - 40) after adjusting for confounders...
  6. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2007
    ..The primary outcome will be change between baseline and year 3 in forced expiratory volume in the first second (FEV1)...
  7. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2004
    ..The primary outcome will be change between baseline and year 3 in forced expiratory volume in the first second (FEV1)...
  8. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2003
    ..The primary outcome will be change between baseline and year 3 in forced expiratory volume in the first second (FEV1)...
  9. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2006
    ..The primary outcome will be change between baseline and year 3 in forced expiratory volume in the first second (FEV1)...
  10. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2005
    ..The primary outcome will be change between baseline and year 3 in forced expiratory volume in the first second (FEV1)...
  11. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1980
    ..resistance, functional residual capacity, maximum flow a 50% and 75% of expired vital capacity and forced expiratory volume in one second...
  12. Indoor woodsmoke PM and asthma: a randomized trial
    Anthony Ward; Fiscal Year: 2009
    ..outcomes measured prior to and following the intervention will include peak expiratory flow (PEF) and forced expiratory volume in first second (FEV1), biomarkers in exhaled breath condensate (i.e...
  13. Indoor woodsmoke PM and asthma: a randomized trial
    ANTHONY JOHN contact WARD; Fiscal Year: 2010
    ..outcomes measured prior to and following the intervention will include peak expiratory flow (PEF) and forced expiratory volume in first second (FEV1), biomarkers in exhaled breath condensate (i.e...
  14. Developing an Automated Symptom Monitoring Device for Adolescents with Asthma
    Hyekyun Rhee; Fiscal Year: 2009
    ..Data from ADAM will be compared with Forced Expiratory Volume at 1 second, exhaled fractional nitric oxide, and data from questionnaires including the Asthma Control ..
  15. Developing an Automated Symptom Monitoring Device for Adolescents with Asthma
    HYEKYUN contact RHEE; Fiscal Year: 2010
    ..Data from ADAM will be compared with Forced Expiratory Volume at 1 second, exhaled fractional nitric oxide, and data from questionnaires including the Asthma Control ..
  16. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009
    ..The primary outcome will be change in forced expiratory volume in one second (FEV1) slope over twelve months...
  17. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2007
    ..The primary outcome will be change in forced expiratory volume in one second (FEV1) slope over twelve months...
  18. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2011
    ..and PCR-confirmed viral infection on asthma health outcomes (primarily: fluctuations in daily measures of forced expiratory volume in 1 second (FEV1) and frequency of self-reported wheezing)...
  19. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2010
    ..and PCR-confirmed viral infection on asthma health outcomes (primarily: fluctuations in daily measures of forced expiratory volume in 1 second (FEV1) and frequency of self-reported wheezing)...
  20. Study of Soy Isoflavones in Asthma (SOYA)
    Lewis J Smith; Fiscal Year: 2012
    ..The primary outcome measure is forced expiratory volume in one second (FEV1), an objective measure of lung function...
  21. Study of Soy Isoflavones in Asthma (SOYA)
    Lewis J Smith; Fiscal Year: 2010
    ..The primary outcome measure is forced expiratory volume in one second (FEV1), an objective measure of lung function...
  22. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1990
    ..In all studies the primary pulmonary functions to be assessed will be forced expiratory volume in one second (FEV1), total respiratory resistance and maximal flow...
  23. Study of Soy Isoflavones in Asthma (SOYA)
    LEWIS SMITH; Fiscal Year: 2009
    ..The primary outcome measure is forced expiratory volume in one second (FEV1), an objective measure of lung function...
  24. Study of Soy Isoflavones in Asthma (SOYA)
    Robert Wise; Fiscal Year: 2009
    ..The primary outcome measure is forced expiratory volume in one second (FEV1), an objective measure of lung function...
  25. Family Based Analysis of Modifiers of CF Lung Disease
    Hara Levy; Fiscal Year: 2005
    ..factors that account for the variability in expression of CF lung disease as measured by lung function, forced expiratory volume in one second (FEV1), in patients with the delta 508 genotype...
  26. Family Based Analysis of Modifiers of CF Lung Disease
    Hara Levy; Fiscal Year: 2006
    ..factors that account for the variability in expression of CF lung disease as measured by lung function, forced expiratory volume in one second (FEV1), in patients with the delta 508 genotype...
  27. Family Based Analysis of Modifiers of CF Lung Disease
    Hara Levy; Fiscal Year: 2007
    ..factors that account for the variability in expression of CF lung disease as measured by lung function, forced expiratory volume in one second (FEV1), in patients with the delta 508 genotype...
  28. School Environmental Exposures and Measures of the Asthmatic Disease Process
    ELANOR SIDMAN; Fiscal Year: 2007
    ..The children will be asked to provide exhaled breath samples and forced expiratory volume in 1 second (FEV1) measurements during a home visit and then twice during a single school visit...
  29. "Defining Chronic Obstructive Pulmonary Disease in Older Persons"
    Carlos A Vaz Fragoso; Fiscal Year: 2010
    ..obstructive pulmonary disease (COPD) is defined spirometrically, based solely on a reduced ratio of the forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC), with severity subsequently staged according to the ..
  30. Phase 3 Study of PTC124 in Cystic Fibrosis (IND 48,648)
    JAY A BARTH; Fiscal Year: 2010
    ..include 208 patients with nonsense-mutation-mediated CF who are at least 6 years of age and have a forced expiratory volume in 1 second (FEV1) between 40% and 90% of predicted...
  31. Family Based Analysis of Modifiers of CF Lung Disease
    Hara Levy; Fiscal Year: 2004
    ..factors that account for the variability in expression of CF lung disease as measured by lung function, forced expiratory volume in one second (FEV1), in patients with the delta 508 genotype...
  32. Family Based Analysis of Modifiers of CF Lung Disease
    Hara Levy; Fiscal Year: 2003
    ..factors that account for the variability in expression of CF lung disease as measured by lung function, forced expiratory volume in one second (FEV1), in patients with the delta 508 genotype...
  33. PREDICTORS OF QUALITY OF LIFE: LUNG TRANSPLANT PATIENTS
    Dorothy Lanuza; Fiscal Year: 2002
    ..g., forced expiratory volume in 1 second [FEV1], blood pressure [BP], heart rate [HR]); 2) distance walked in 6-minute walk test; 3) ..
  34. A RANDOMIZED TRIAL TO REDUCE ETS IN CHILDREN WITH ASTHMA
    Bruce Lanphear; Fiscal Year: 2001
    ..reduction group will have improvement in pulmonary function as measured by >10 percent difference in forced expiratory volume at 1 second (FEV 1) and >15 percent difference in forced expiratory fraction of 25 percent-75 percent (..
  35. PREDICTORS OF QUALITY OF LIFE: LUNG TRANSPLANT PATIENTS
    Dorothy Lanuza; Fiscal Year: 2001
    ..g., forced expiratory volume in 1 second [FEV1], blood pressure [BP], heart rate [HR]); 2) distance walked in 6-minute walk test; 3) ..
  36. A RANDOMIZED TRIAL TO REDUCE ETS IN CHILDREN WITH ASTHMA
    Bruce Lanphear; Fiscal Year: 2002
    ..reduction group will have improvement in pulmonary function as measured by >10 percent difference in forced expiratory volume at 1 second (FEV 1) and >15 percent difference in forced expiratory fraction of 25 percent-75 percent (..
  37. A RANDOMIZED TRIAL TO REDUCE ETS IN CHILDREN WITH ASTHMA
    Bruce Lanphear; Fiscal Year: 2003
    ..reduction group will have improvement in pulmonary function as measured by >10 percent difference in forced expiratory volume at 1 second (FEV 1) and >15 percent difference in forced expiratory fraction of 25 percent-75 percent (..
  38. A RANDOMIZED TRIAL TO REDUCE ETS IN CHILDREN WITH ASTHMA
    Bruce Lanphear; Fiscal Year: 2000
    ..reduction group will have improvement in pulmonary function as measured by >10 percent difference in forced expiratory volume at 1 second (FEV 1) and >15 percent difference in forced expiratory fraction of 25 percent-75 percent (..
  39. PREDICTORS OF QUALITY OF LIFE: LUNG TRANSPLANT PATIENTS
    Dorothy Lanuza; Fiscal Year: 2000
    ..g., forced expiratory volume in 1 second [FEV1], blood pressure [BP], heart rate [HR]); 2) distance walked in 6-minute walk test; 3) ..
  40. PREDICTORS OF QUALITY OF LIFE: LUNG TRANSPLANT PATIENTS
    Dorothy Lanuza; Fiscal Year: 2004
    ..g., forced expiratory volume in 1 second [FEV1], blood pressure [BP], heart rate [HR]); 2) distance walked in 6-minute walk test; 3) ..
  41. PREDICTORS OF QUALITY OF LIFE: LUNG TRANSPLANT PATIENTS
    Dorothy Lanuza; Fiscal Year: 2003
    ..g., forced expiratory volume in 1 second [FEV1], blood pressure [BP], heart rate [HR]); 2) distance walked in 6-minute walk test; 3) ..
  42. Early Intervention in Pulmonary Exacerbation in CF
    Noah Lechtzin; Fiscal Year: 2010
    ..will be compared to usual care with the primary outcome measure being lung function as measured with forced expiratory volume in the first second (FEV1)...
  43. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2009
    ..was found to significantly improve pulmonary function (reduced Peak Flow variability (PEFRvar), increase Forced Expiratory Volume in 1 second (FEV1), and to reduce asthma medication use and symptom severity (shortness of breath, chest ..
  44. Phase 2 study of VX-770 in Cystic Fibrosis Subjectswith G551D
    CLAUDIA ORDONEZ; Fiscal Year: 2007
    ..Secondary endpoints will be nasal potential difference (NPD), sweat chloride, forced expiratory volume in 1 second (FEV1), and pharmacokinetic parameters...
  45. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2009
    ..in ICS response with only 33 per cent to 50 per cent of patients demonstrating substantial improvement in forced expiratory volume in 1 second (FEV1) following therapy...
  46. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2010
    ..in ICS response with only 33 per cent to 50 per cent of patients demonstrating substantial improvement in forced expiratory volume in 1 second (FEV1) following therapy...
  47. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2009
    ..in ICS response with only 33 per cent to 50 per cent of patients demonstrating substantial improvement in forced expiratory volume in 1 second (FEV1) following therapy...
  48. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 1999
    ..including: confirmed parental and sibling stroke; hypertension and higher blood pressure levels; lower forced expiratory volume in 1 second; cigarette smoking; diabetes; and, prior cardiovascular disease, stroke or transient ischemic ..
  49. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2000
    ..including: confirmed parental and sibling stroke; hypertension and higher blood pressure levels; lower forced expiratory volume in 1 second; cigarette smoking; diabetes; and, prior cardiovascular disease, stroke or transient ischemic ..
  50. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2002
    ..including: confirmed parental and sibling stroke; hypertension and higher blood pressure levels; lower forced expiratory volume in 1 second; cigarette smoking; diabetes; and, prior cardiovascular disease, stroke or transient ischemic ..
  51. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2003
    ..including: confirmed parental and sibling stroke; hypertension and higher blood pressure levels; lower forced expiratory volume in 1 second; cigarette smoking; diabetes; and, prior cardiovascular disease, stroke or transient ischemic ..
  52. PRECURSORS OF STROKE INCIDENCE AND PROGNOSIS
    Philip Wolf; Fiscal Year: 2001
    ..including: confirmed parental and sibling stroke; hypertension and higher blood pressure levels; lower forced expiratory volume in 1 second; cigarette smoking; diabetes; and, prior cardiovascular disease, stroke or transient ischemic ..
  53. Redox disturbances and corticosteroid responses in children with severe asthma
    ANNE MENTRO FITZPATRICK; Fiscal Year: 2010
    ..Corticosteroid insensitivity will be defined as <15% improvement in the forced expiratory volume in one second 4 weeks after triamcinolone administration...
  54. NATIONAL COOPERATIVE INNER-CITY ASTHMA STUDY
    James Stout; Fiscal Year: 2000
    ..be assessed according to the following four domains: (1) physiologic measures (methacholine challenge, forced expiratory volume in one second (FEV-1), peak expiratory flow rate; (2) health care use (asthma hospitalizations and acute ..
  55. NATIONAL COOPERATIVE INNER CITY ASTHMA STUDY
    James Stout; Fiscal Year: 1999
    ..be assessed according to the following four domains: (1) physiologic measures (methacholine challenge, forced expiratory volume in one second (FEV-1), peak expiratory flow rate; (2) health care use (asthma hospitalizations and acute ..
  56. NATIONAL COOPERATIVE INNER-CITY ASTHMA STUDY
    James Stout; Fiscal Year: 2001
    ..be assessed according to the following four domains: (1) physiologic measures (methacholine challenge, forced expiratory volume in one second (FEV-1), peak expiratory flow rate; (2) health care use (asthma hospitalizations and acute ..
  57. NATIONAL COOPERATIVE INNER-CITY ASTHMA STUDY
    James Stout; Fiscal Year: 2001
    ..be assessed according to the following four domains: (1) physiologic measures (methacholine challenge, forced expiratory volume in one second (FEV-1), peak expiratory flow rate; (2) health care use (asthma hospitalizations and acute ..
  58. NATIONAL COOPERATIVE INNER-CITY ASTHMA STUDY
    James Stout; Fiscal Year: 1999
    ..be assessed according to the following four domains: (1) physiologic measures (methacholine challenge, forced expiratory volume in one second (FEV-1), peak expiratory flow rate; (2) health care use (asthma hospitalizations and acute ..
  59. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2006
    ..The response to beta2-agonists in acute asthma is traditionally determined by the change in the forced expiratory volume in the first second (FEV1,) measured using a forced expiratory maneuver preceded by deep inhalation (DI)...
  60. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2005
    ..The response to beta2-agonists in acute asthma is traditionally determined by the change in the forced expiratory volume in the first second (FEV1,) measured using a forced expiratory maneuver preceded by deep inhalation (DI)...
  61. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2007
    ..The response to beta2-agonists in acute asthma is traditionally determined by the change in the forced expiratory volume in the first second (FEV1,) measured using a forced expiratory maneuver preceded by deep inhalation (DI)...
  62. Nutritional influences on lung function
    PATRICIA CASSANO; Fiscal Year: 2001
    ..1987) will be examined in relation to pulmonary outcomes over the subsequent 13-year period, including forced expiratory volume in the first second (FEV1), methacholine airways responsiveness, and incident COPD...
  63. Nutritional influences on lung function
    PATRICIA CASSANO; Fiscal Year: 2002
    ..1987) will be examined in relation to pulmonary outcomes over the subsequent 13-year period, including forced expiratory volume in the first second (FEV1), methacholine airways responsiveness, and incident COPD...
  64. FARM RELATED ASTHMA
    Kenneth Rosenman; Fiscal Year: 2003
    ..who meet the NIOSH SENSOR criteria for work-related asthma will be offered electronic peak flow and Forced Expiratory Volume in one second testing over a two week period, to determine if there are changes on pulmonary function ..
  65. Risk factors for site-specific metastasis in esophageal cancer
    JULIAN ABRAMS; Fiscal Year: 2010
    ..Lung damage will be quantified by forced expiratory volume (one second) and by the major urinary prostaglandin-E2 metabolite, an experimental measure of tobacco-..
  66. Risk factors for site-specific metastasis in esophageal cancer
    JULIAN ABRAMS; Fiscal Year: 2009
    ..Lung damage will be quantified by forced expiratory volume (one second) and by the major urinary prostaglandin-E2 metabolite, an experimental measure of tobacco-..
  67. IMPROVING CHRONIC DISEASE HEALTH STATUS AND UTILIZATION
    Jan Wallander; Fiscal Year: 2000
    ..Health status is assessed by forced expiratory volume and body mass index at 3 months post-intervention...
  68. Risk factors for site-specific metastasis in esophageal cancer
    JULIAN ABRAMS; Fiscal Year: 2009
    ..Lung damage will be quantified by forced expiratory volume (one second) and by the major urinary prostaglandin-E2 metabolite, an experimental measure of tobacco-..
  69. Discovering Pathways of Functional Decline: A GWAS Approach
    Stephen Kritchevsky; Fiscal Year: 2009
    ..total mortality and the onset of mobility limitations: grip strength, usual gait speed, IL-6 levels, and forced expiratory volume in 1s (FEV1)...
  70. Discovering Pathways of Functional Decline: A GWAS Approach
    Yongmei Liu; Fiscal Year: 2010
    ..total mortality and the onset of mobility limitations: grip strength, usual gait speed, IL-6 levels, and forced expiratory volume in 1s (FEV1)...
  71. Investigating Effects of Viral Infection on Lung Development
    ROBERT LEMANSKE; Fiscal Year: 2009
    ..End of Abstract) ..
  72. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  73. IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
    David Skoner; Fiscal Year: 2003
    ..The primary hypothesis is that cytokine genotype is predictive of illness expression and of OM incidence during a documented RSV infection in young children. ..
  74. Phone Calls to Promote Adherence with Inhaled Corticoste
    William Vollmer; Fiscal Year: 2006
    ..This method, if it helps people take their medications as prescribed, could be used with a variety of other long-term medical conditions. ..
  75. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  76. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..