pulmonary gas exchange

Summary

Summary: The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.

Top Publications

  1. ncbi Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death
    Anselm K Gitt
    Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
    Circulation 106:3079-84. 2002
  2. ncbi Reproducibility of maximal exercise test data in the HERITAGE family study
    J S Skinner
    Indiana University, Bloomington, USA
    Med Sci Sports Exerc 31:1623-8. 1999
  3. ncbi Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
  4. pmc Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe
    Bastiaan Driehuys
    Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, NC 27710, USA
    Radiology 252:386-93. 2009
  5. doi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
  6. ncbi Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2
    J P Whiteley
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Anaesth 88:771-8. 2002
  7. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
  8. ncbi Probing lung physiology with xenon polarization transfer contrast (XTC)
    K Ruppert
    Department of Radiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Magn Reson Med 44:349-57. 2000
  9. ncbi Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension
    B Rosengarten
    Department of Neurology, University Hospital, Justus Liebig University Giessen, Giessen, Germany
    Cerebrovasc Dis 21:194-200. 2006
  10. ncbi Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002

Detail Information

Publications240 found, 100 shown here

  1. ncbi Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death
    Anselm K Gitt
    Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
    Circulation 106:3079-84. 2002
    ..Thus, we compared these parameters with peak VO2 in identifying patients with CHF at increased risk for death within 6 months after evaluation...
  2. ncbi Reproducibility of maximal exercise test data in the HERITAGE family study
    J S Skinner
    Indiana University, Bloomington, USA
    Med Sci Sports Exerc 31:1623-8. 1999
    ..The reproducibility of responses to maximal cycle ergometer testing was determined using data from the HERITAGE Family study at four Clinical Centers in the United States and Canada...
  3. ncbi Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
    ..The current data supports the concept that patchy ventilation is an expression of the integrated system and not just the sum of independent responses of individual airways...
  4. pmc Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe
    Bastiaan Driehuys
    Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, NC 27710, USA
    Radiology 252:386-93. 2009
    ....
  5. doi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
    ..In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction...
  6. ncbi Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2
    J P Whiteley
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Anaesth 88:771-8. 2002
    ..Measures of impairment of oxygenation can be affected by the inspired oxygen fraction...
  7. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  8. ncbi Probing lung physiology with xenon polarization transfer contrast (XTC)
    K Ruppert
    Department of Radiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Magn Reson Med 44:349-57. 2000
    ..It is further argued that minor pulse-sequence modifications may provide information about the alveolar surface area or lung perfusion...
  9. ncbi Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension
    B Rosengarten
    Department of Neurology, University Hospital, Justus Liebig University Giessen, Giessen, Germany
    Cerebrovasc Dis 21:194-200. 2006
    ..We investigated the impact of these agents on cerebral microcirculatory regulation in patients suffering from this disease...
  10. ncbi Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002
    ..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
  11. ncbi Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings
    T A Altes
    Department of Radiology, University of Virginia, Charlottesville, Virginia, USA
    J Magn Reson Imaging 13:378-84. 2001
    ..Hyperpolarized 3He lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy...
  12. ncbi Validity and reliability of selected commercially available metabolic analyzer systems
    L D Hodges
    Research Centre for Health Studies, Buckinghamshire Chilterns University College, Buckinghamshire, UK
    Scand J Med Sci Sports 15:271-9. 2005
    ..This presents a significant practical challenge in light of the speed with which technical developments in the field occur and we make some suggestions for the formulation of intersystem comparison studies...
  13. doi Preoperative gender differences in pulmonary gas exchange in morbidly obese subjects
    Gerald S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, 6420 Clayton Road, Suite 290, Saint Louis, MO 63117, USA
    Obes Surg 18:1587-98. 2008
    Morbidly obese men may have poorer pulmonary gas exchange compared to morbidly obese women (see Zavorsky et al., Chest 131:362-367, 2007)...
  14. ncbi Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model
    Carissa L Bellardine
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 34:439-45. 2006
    ..We aimed at testing VV in a large animal lung injury model and exploring the mechanism of improvement in gas exchange seen with VV...
  15. doi Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    Zhenguo Zhai
    Imperial College School of Medicine, Imperial College London, London, England
    Chest 140:1284-91. 2011
    ..Little is known about whether these measures can be applied to all forms of PH, in particular chronic thromboembolic pulmonary hypertension (CTEPH), wherein thrombotic vascular occlusion has an impact on gas exchange...
  16. ncbi Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia
    A J Rice
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000
    J Appl Physiol (1985) 87:1802-12. 1999
    ..95, P < 0.001). These data suggest that EIH has a multifactorial etiology related to DL(O(2)), VA/Q inequality, and ventilation...
  17. doi Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study
    B Koch
    Medical Faculty of the Ernst Moritz Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23, D 17475 Greifswald, Germany
    Eur Respir J 33:389-97. 2009
    ..While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey...
  18. ncbi Exercise pathophysiology in patients with primary pulmonary hypertension
    X G Sun
    Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
    Circulation 104:429-35. 2001
    ..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
  19. ncbi Cardiac reserve and pulmonary gas exchange kinetics in patients with stroke
    Corey R Tomczak
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton AB, Canada
    Stroke 39:3102-6. 2008
    ..We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects.
  20. ncbi Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis
    H Olschewski
    Depatment of Internal Medicine II, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 160:600-7. 1999
    ..Long-term therapy with inhaled iloprost may be life saving in decompensated right heart failure from pulmonary hypertension secondary to lung fibrosis...
  21. ncbi Acute asthma in adults: a review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 125:1081-102. 2004
    ..This review describes the epidemiology, costs, pathophysiology, mortality, and management of adult AA in the ED and in the ICU...
  22. ncbi Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines
    Eric K Chu
    Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care Med 32:168-74. 2004
    ..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
  23. ncbi Prevention of atelectasis formation during induction of general anesthesia
    Marco Rusca
    Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 97:1835-9. 2003
    ..005). Atelectasis formation is prevented by application of PEEP during the anesthesia induction despite the use of large oxygen concentrations, resulting in improved oxygenation...
  24. ncbi The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases
    R Kessler
    Department of Pulmonology and Sleep Laboratory, University Hospital, Strasbourg, France
    Chest 120:369-76. 2001
    ..We compare also OHS patients with a group of patients with the association of OSAS and COPD, also known as "overlap" patients...
  25. ncbi Quantitative measurement of regional lung ventilation using 3He MRI
    Anselm J Deninger
    Amersham Health R and D, Medeon, SE 205 12 Malmö, Sweden
    Magn Reson Med 48:223-32. 2002
    ..The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values...
  26. ncbi Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome
    Elena Gastiasoro-Cuesta
    Department of Pediatrics, Hospital de Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
    Pediatrics 117:295-303. 2006
    ..To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model...
  27. doi Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patients
    W A Almarakbi
    Department of Anesthesia, Ain Shams University, Cairo, Egypt
    Br J Anaesth 102:862-8. 2009
    ..This study was performed to determine whether repeated lung recruitment combined with PEEP improves respiratory compliance and arterial partial pressure of oxygen (Pa(O2)) in obese patients undergoing laparoscopic gastric banding...
  28. ncbi High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
  29. ncbi Influence of exogenous fat emulsion on pulmonary gas exchange after major surgery
    Souji Sane
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    World J Surg 26:297-302. 2002
    ..The aim of this study was to evaluate the influence of exogenous fat emulsion on pulmonary gas exchange in the early period after major surgery...
  30. ncbi Sigh in supine and prone position during acute respiratory distress syndrome
    Paolo Pelosi
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Ospedale di Circolo, Fondazione Macchi, Varese
    Am J Respir Crit Care Med 167:521-7. 2003
    ..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
  31. ncbi Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchange
    S Kjaergaard
    Aalborg Hospital, Department of Anaesthesiology, Aalborg, Denmark
    Eur J Anaesthesiol 21:296-301. 2004
    To investigate the clinical application of a mathematical model of pulmonary gas exchange, which ascribes hypoxaemia to shunt and ventilation/perfusion mismatch...
  32. ncbi Pulmonary gas exchange is reduced by the cardiovascular diving response in resting humans
    Johan P A Andersson
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Respir Physiol Neurobiol 160:320-4. 2008
    ..4 ml min(-1)kg(-1)). We conclude that the cardiovascular adjustments of the diving response reduces pulmonary gas exchange in resting humans, allowing longer apneas by preserving the lungs' O(2) store for use by vital organs.
  33. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
    The literature on pulmonary gas exchange at rest, during exercise, and with weight loss in the morbidly obese (body mass index or BMI > or = 40 kg m(-2)) is reviewed...
  34. ncbi Performance characteristics of gas analysis systems: what we know and what we need to know
    G Atkinson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    Int J Sports Med 26:S2-10. 2005
    ..We stressed that this judgement should be based on expert-agreed position statements about acceptable error, which unfortunately have yet to be formulated for gas analysis systems...
  35. ncbi Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Am J Respir Crit Care Med 165:366-71. 2002
    ..05) compared with conventional ventilation. These data indicate that variable ventilation is effective in improving lung function and gas exchange during acute lung injury...
  36. ncbi Perfluorocarbon species and nebulizer type influence aerosolization rate and particle size of perfluorocarbon aerosol
    Mario Rudiger
    Clinic for Neonatology, Charite Campus Mitte, Berlin, Germany
    J Crit Care 19:42-7. 2004
    ..Aerosolization of perfluorocarbons (PFC) has been proven beneficial in vivo. The present in vitro study was performed to investigate, how PFC-aerosolization is affected by type of nebulizer and PFC properties...
  37. ncbi Exercise-induced intrapulmonary arteriovenous shunting and pulmonary gas exchange
    Michael K Stickland
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1532, USA
    Exerc Sport Sci Rev 34:99-106. 2006
    ..intrapulmonary shunt vessels during exercise, which may contribute to the exercise-induced impairment in pulmonary gas exchange. These findings are consistent with substantial anatomical data demonstrating large-diameter (> 25 ..
  38. ncbi Effects of spontaneous breathing during airway pressure release ventilation on intestinal blood flow in experimental lung injury
    Rudolf Hering
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Anesthesiology 99:1137-44. 2003
    ..The authors hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and intestinal blood flow than APRV without SB...
  39. ncbi Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humans
    Shoji Ito
    Department of Anaesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
    Exp Physiol 91:935-41. 2006
    ..arrhythmia (RSA) and anatomical dead space volume, respectively, contribute to improve the efficiency of pulmonary gas exchange in humans. We examined the effect of blocking vagal nerve activity with atropine on pulmonary gas exchange...
  40. ncbi Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humans
    Nicholas D Giardino
    Department of Rehabilitation Medicine, University of Washington, 1959 SE Pacific Street, Seattle, WA 98195, USA
    Am J Physiol Heart Circ Physiol 284:H1585-91. 2003
    Respiratory sinus arrhythmia (RSA) may be associated with improved efficiency of pulmonary gas exchange by matching ventilation to perfusion within each respiratory cycle. Respiration rate, tidal volume, minute ventilation (...
  41. ncbi Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment
    Jeffrey M Halter
    Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Am J Respir Crit Care Med 167:1620-6. 2003
    ..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
  42. ncbi Relation between PaO2/FIO2 ratio and FIO2: a mathematical description
    Jerome Aboab
    Réanimation Médicale, AP HP, Hopital Henri Mondor, 51, av du Maréchal de Lattre de Tassigny, 94010 Creteil, France
    Intensive Care Med 32:1494-7. 2006
  43. ncbi Non-invasive estimation of shunt and ventilation-perfusion mismatch
    Søren Kjaergaard
    Department of Anaesthesiology, Aalborg Hospital, Aarhus University Hospitals, 9000 Aalborg, Denmark
    Intensive Care Med 29:727-34. 2003
    To investigate whether parameters describing pulmonary gas exchange (shunt and ventilation-perfusion mismatch) can be estimated consistently by the use of non-invasive data as input to a mathematical model of oxygen transport.
  44. ncbi A methodology to assess the accuracy of a portable metabolic system (VmaxST)
    Fabrice Prieur
    Laboratoire d Analyse Multidisciplinaire des Pratiques Sportives, UFR STAPS de Liévin, Université d Artois, Lievin, France
    Med Sci Sports Exerc 35:879-85. 2003
    ..Validity of a portable metabolic system (VmaxST) was investigated during gas exchanges simulations by a mechanical system (GESS) and during human exercise...
  45. ncbi Topographic basis of bimodal ventilation-perfusion distributions during bronchoconstriction in sheep
    Marcos F Vidal Melo
    Cardiac Anesthesia Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 171:714-21. 2005
    ..Assessment of the subresolution VA/Q heterogeneity is therefore essential to accurately quantify global gas exchange impairment during bronchoconstriction...
  46. pmc The prone position results in smaller ventilation defects during bronchoconstriction in asthma
    R Scott Harris
    Department of Medicine, Pulmonary and Critical Care Unit, Bulfinch 148, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol (1985) 107:266-74. 2009
    ..In asthma, the size and location of ventilation defects is affected by body position and likely affected by small differences in lung expansion during bronchoconstriction...
  47. doi Flow-through respirometry applied to chamber systems: pros and cons, hints and tips
    J R B Lighton
    Department of Biology, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154 4004, USA
    Comp Biochem Physiol A Mol Integr Physiol 158:265-75. 2011
    ....
  48. doi Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury
    Alysson R Carvalho
    Clinic of Anesthesiology and Intensive Care Therapy, Univ Hospital Dresden, Dresden, Germany
    J Appl Physiol (1985) 110:1083-92. 2011
    ..Random variation of pressure support further redistributes PBF and improves oxygenation compared with conventional PSV...
  49. doi Minimal model quantification of pulmonary gas exchange in intensive care patients
    Dan S Karbing
    Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 204, DK 9220 Aalborg East, Denmark
    Med Eng Phys 33:240-8. 2011
    Mathematical models are required to describe pulmonary gas exchange. The challenge remains to find models which are complex enough to describe physiology and simple enough for clinical practice...
  50. ncbi Cardiopulmonary response to exercise in patients with liver cirrhosis and impaired pulmonary gas exchange
    Malcolm Lemyze
    Department of Respiratory and Critical Care Medicine, Schaffner Hospital, 99 route de La Bassée, Lens, France
    Respir Med 105:1550-6. 2011
    Maximal exercise capacity and pulmonary gas exchange are both commonly impaired in liver cirrhosis...
  51. ncbi An experimental rat model of ex vivo lung perfusion for the assessment of lungs after prostacyclin administration: inhaled versus parenteral routes
    Paulo Francisco Guerreiro Cardoso
    Department of Cardiorespiratory Diseases, Thoracic Surgery Section, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    J Bras Pneumol 37:589-97. 2011
    ..To present a model of prostaglandin I2 (PGI2) administration (inhaled vs. parenteral) and to assess the functional performance of the lungs in an ex vivo lung perfusion system...
  52. ncbi Comparison of effects of perflubron and surfactant lung lavage on pulmonary gas exchange in a piglet model of meconium aspiration
    Rolf L Schlosser
    Department of Pediatrics, Johann Wolfgang Goethe University Hospital, Frankfurt Main, Germany
    Biol Neonate 81:126-31. 2002
    ..Lavage with exogenous surfactant as well as with PFOB improve pulmonary gas exchange in a piglet model of meconium aspiration.
  53. ncbi Pressure support compared with controlled mechanical ventilation in experimental lung injury
    Rolf Dembinski
    Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesth Analg 94:1570-6, table of contents. 2002
    ..005). We conclude that, in this model of ALI, PSV improves gas exchange because of a reduction of .V(A)/.Q inequality. However, improvements in .V(A)/.Q distribution may be more effective with CMV than with PSV...
  54. doi Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome
    Xabier Murgia
    Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Bizkaia, Spain
    Pediatr Res 72:393-9. 2012
    ..Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated...
  55. pmc A mathematical model of pulmonary gas exchange under inflammatory stress
    Angela Reynolds
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 264:161-73. 2010
    ....
  56. pmc Validity, reliability and stability of the portable Cortex Metamax 3B gas analysis system
    D J MacFarlane
    Institute of Human Performance, The University of Hong Kong, Pokfulam, Hong Kong
    Eur J Appl Physiol 112:2539-47. 2012
    ..It is concluded the MM3B produces acceptably stable and reliable results, but is not adequately valid during moderate and vigorous exercise without some further correction of VO(2) and VCO(2)...
  57. pmc Clinical review: Extracorporeal membrane oxygenation
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Crit Care 15:243. 2011
    ..The current enthusiasm for ECMO in its various aspects should not, however, obscure the consideration of the potential complications associated with this life-saving technique, primarily brain hemorrhage...
  58. pmc Hyperpolarized Xe MR imaging of alveolar gas uptake in humans
    Zackary I Cleveland
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e12192. 2010
    ..However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange...
  59. ncbi Influence of a vital capacity maneuver on pulmonary gas exchange after cardiopulmonary bypass
    G S Murphy
    Departments of Anesthesia and Surgery, Evanston Northwestern Healthcare/Northwestern University, Evanston, IL, USA
    J Cardiothorac Vasc Anesth 15:336-40. 2001
    ..breath (vital capacity maneuver [VCM]), administered at the end of cardiopulmonary bypass (CPB), on pulmonary gas exchange in patients undergoing coronary artery bypass graft surgery...
  60. ncbi Interactions between heart rate variability and pulmonary gas exchange efficiency in humans
    Peter Y W Sin
    Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
    Exp Physiol 95:788-97. 2010
    ..component of heart rate variability (respiratory sinus arrhythmia, RSA) has been associated with improved pulmonary gas exchange efficiency in humans via the apparent clustering and scattering of heart beats in time with the ..
  61. ncbi Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchange
    D Torbati
    Division Critical Care Medicine, Miami Children s Hospital, FL 33155 3009, USA
    Crit Care Med 27:1878-84. 1999
    ..To compare normative ventilatory and gas-exchange data and anesthetic requirements in male and female rats subjected to critical care conditions...
  62. ncbi Pulmonary gas exchange during exercise in pigs
    S R Hopkins
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623
    J Appl Physiol (1985) 86:93-100. 1999
    ..These data suggest that the pig animal model is well suited for studying the mechanism of exercise-induced VA/Q inequality...
  63. ncbi Thin-section CT abnormalities and pulmonary gas exchange impairment in workers exposed to asbestos
    Andrea Sette
    Pulmonary Function and Clinical Exercise Physiology Unit, Div of Respiratory Diseases, Federal Univ of São Paulo, Rua Professor Francisco de Castro 54, Vila Clementino, CEP 04020 050 São Paulo, Brazil
    Radiology 232:66-74. 2004
    To evaluate the relationship between abnormalities at thin-section computed tomography (CT) and indexes of pulmonary gas exchange impairment at rest and during moderate exercise in workers exposed to asbestos.
  64. ncbi Understanding pulmonary gas exchange: ventilation-perfusion relationships
    John B West
    Am J Physiol Lung Cell Mol Physiol 287:L1071-2. 2004
    ..Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949 (http://ajplegacy.physiology.org/cgi/reprint/158/1/21)). Riley RL...
  65. doi Influence of age, sex, body size, smoking, and beta blockade on key gas exchange exercise parameters in an adult population
    Sven Glaser
    Medical Faculty of the Ernst Moritz Arndt University, Department of Internal Medicine B Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Street 23, D 17475 Greifswald, Germany
    Eur J Cardiovasc Prev Rehabil 17:469-76. 2010
    ..This study planned to consider the impact of these factors on CPET values and develop reference equations on the basis of a large-scale population-based survey...
  66. ncbi Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture
    F Staffieri
    Section of Critical Care and Anesthesia, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
    Equine Vet J 41:747-52. 2009
    ..It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange...
  67. doi Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
    ..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
  68. ncbi Oxygen in air (FiO2 0.4) improves gas exchange in young healthy patients during general anesthesia
    Anil Agarwal
    Department of Anesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Can J Anaesth 49:1040-3. 2002
    ..higher the O(2) concentration the faster is the development of atelectasis, an important cause of impaired pulmonary gas exchange during general anesthesia (GA). We evaluated the effect of ventilation with 0.4 FiO(2) in air, 0...
  69. ncbi Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans
    Andrew T Lovering
    Department of Human Physiology, 1240 University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol (1985) 104:1418-25. 2008
    ..were made into a peripheral vein at rest and during exercise and recovery (3-5 min postexercise) with pulmonary gas exchange measured simultaneously...
  70. doi Teaching pulmonary gas exchange physiology using computer modeling
    Kent S Kapitan
    Division of Pulmonary Medicine, School of Medicine, Southern Illinois University, Springfield, Illinois 62794 9636, USA
    Adv Physiol Educ 32:61-4. 2008
    ..To overcome this difficulty, I have developed an interactive computer simulation of pulmonary gas exchange that is web based and allows the student to vary multiple factors simultaneously and observe the final ..
  71. pmc Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung
    G Kim Prisk
    Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
    J Appl Physiol (1985) 108:53-9. 2010
    ..We hypothesized that infusion would disrupt pulmonary gas exchange by increasing ventilation/perfusion ((.)VA/(...
  72. ncbi Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension
    Isabel Blanco
    Department of Pulmonary Medicine, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona
    Am J Respir Crit Care Med 181:270-8. 2010
    ..However, vasodilators may inhibit hypoxic pulmonary vasoconstriction and impair gas exchange in this condition...
  73. ncbi Systematic review of noninvasive positive pressure ventilation in severe stable COPD
    M A Kolodziej
    Dept of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospitals, University of Alberta, Edmonton, AB, Canada
    Eur Respir J 30:293-306. 2007
    ....
  74. ncbi Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation
    Y Imai
    Pathophysiology Research Laboratory, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8509, Japan
    J Appl Physiol 91:1836-44. 2001
    ..Conventional mechanical ventilation using lung protection strategies (low V(T) high PEEP) only attenuated the decrease in oxygenation and pulmonary compliance. Therefore, HFOV may be a preferable option as a lung protection strategy...
  75. ncbi Prone positioning improves oxygenation in post-traumatic lung injury--a prospective randomized trial
    Gregor Voggenreiter
    Department of Trauma Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
    J Trauma 59:333-41; discussion 341-3. 2005
    ..In a prospective randomized trial the effect of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients and was compared with patients ventilated in supine position...
  76. ncbi Intercomparison of recruitment maneuver efficacy in three models of acute lung injury
    Sung Chul Lim
    Department of Pulmonary Critical Care Medicine, Regions Hospital, University of Minnesota, St Paul, MN, USA
    Crit Care Med 32:2371-7. 2004
    ..To compare the relative efficacy of three forms of recruitment maneuvers in diverse models of acute lung injury characterized by differing pathoanatomy...
  77. ncbi Validity of inspiratory and expiratory methods of measuring gas exchange with a computerized system
    D R Bassett
    Department of Exercise Science and Sport Management, University of Tennessee, Knoxville, Tennessee 37996 2700, USA
    J Appl Physiol (1985) 91:218-24. 2001
    ..0004, FE(CO(2)) = -0.0003, VO(2) = -0.018 l/min). Thus a computerized system, using inspiratory or expiratory configurations, permits extremely precise measurements to be made in a less time-consuming manner than the DB technique...
  78. pmc A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injury
    Duane J Funk
    Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
    Respir Res 5:22. 2004
    ....
  79. pmc The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling
    Lisbet Niklason
    Department of Clinical Physiology, University Hospital, Getingevagen 4, SE 221 85 Lund, Sweden
    Crit Care 12:R53. 2008
    ..The purpose of the present study was to analyze the extent to which shunt contributes to alveolar dead space and perturbs carbon dioxide exchange in ancillary physiological disturbances...
  80. ncbi The effects of anesthesia and muscle paralysis on the respiratory system
    Goran Hedenstierna
    Clinical Physiology, Department of Medical Sciences, University Hospital, 75185 Uppsala, Sweden
    Intensive Care Med 31:1327-35. 2005
    ..Moreover, postoperative lung complications occur in 3-10% after elective abdominal surgery and more in emergency operations...
  81. pmc Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevance
    Dan S Karbing
    Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 215, DK 9220 Aalborg East, Denmark
    Crit Care 11:R118. 2007
    ....
  82. pmc Pulmonary perfusion in the prone and supine postures in the normal human lung
    G Kim Prisk
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0931, USA
    J Appl Physiol (1985) 103:883-94. 2007
    Prone posture increases cardiac output and improves pulmonary gas exchange. We hypothesized that, in the supine posture, greater compression of dependent lung limits regional blood flow...
  83. doi Recruitment maneuver in pulmonary and extrapulmonary experimental acute lung injury
    Douglas R Riva
    Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Crit Care Med 36:1900-8. 2008
    ..The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes...
  84. ncbi Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome
    Graciela Martinez-Palli
    Servei d Anestesiologia i Reanimacio Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    World J Gastroenterol 11:6858-62. 2005
    To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome ( HPS ).
  85. pmc Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
    Thorax 62:588-94. 2007
    ..Extensive biochemical and biophysical changes of the pulmonary surfactant system occur in the acute respiratory distress syndrome (ARDS)...
  86. ncbi Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome
    Joao B Borges
    Respiratory Intensive Care Unit, Pulmonary Department, and General Intensive Care Unit, Emergency Clinics Division, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
    Am J Respir Crit Care Med 174:268-78. 2006
    ..The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an efficient maneuver to minimize it...
  87. ncbi Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome
    Stefania Redolfi
    Respiratory Medicine Unit, University of Brescia, Piazzale Spedali Civili 1, 25100 Brescia, Italy
    Respir Med 101:1191-5. 2007
    ..The aim of the study was to investigate the role of leptin in the OHS pathogenesis looking at its relationship to CO(2) sensitivity before and after NIMV in OHS patients...
  88. ncbi Recruitment maneuvers attenuate repeated derecruitment-associated lung injury
    Won Jung Koh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Crit Care Med 33:1070-6. 2005
    ..The aim of this study was to assess lung injury associated with repeated derecruitments and to assess whether this type of injury could be attenuated by recruitment maneuvers...
  89. ncbi Relationship between body and leg VO2 during maximal cycle ergometry
    D R Knight
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623
    J Appl Physiol (1985) 73:1114-21. 1992
    ..We conclude that the asymptotic behavior of whole body VO2 at maximal WRs is a direct reflection of the VO2 profile at the exercising legs...
  90. ncbi Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndrome
    L M Malbouisson
    , Department of Anesthesiology, , , University of Paris VI, 75013 Paris, France
    Am J Respir Crit Care Med 163:1444-50. 2001
    ..76, p = 0.003), suggesting that it may be more accurate than Gattinoni's method...
  91. ncbi Ventilation index and outcome in children with acute respiratory distress syndrome
    G Paret
    Pediatric Intensive Care Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pediatr Pulmonol 26:125-8. 1998
    ..We conclude that the VI provides a reliable prognostic marker in children with ARDS, and its increase above 65 indicates a need for orderly intervention with alternative modalities of care...
  92. ncbi Regional distribution of gas and tissue in acute respiratory distress syndrome. I. Consequences for lung morphology. CT Scan ARDS Study Group
    L Puybasset
    Department of Anesthesiology, Hopital de la Pitie Salpetriere, University of Paris VI and Institut National des Télécommunications, Evry, France
    Intensive Care Med 26:857-69. 2000
    ..To compare the computed tomographic (CT) analysis of the distribution of gas and tissue in the lungs of patients with ARDS with that in healthy volunteers...
  93. ncbi High-frequency ventilation for acute lung injury and ARDS
    J A Krishnan
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Chest 118:795-807. 2000
    ..Second, despite the small VTs, high respiratory rates during HFV allow the maintenance of normal or near-normal PaCO2 levels. In this review, the use of HFV as a lung protective strategy for patients with ALI/ARDS is discussed...
  94. ncbi Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury
    Scott E Sinclair
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, BB 1253 HSB Box 356522, Seattle, WA 98195 6522, USA
    Am J Respir Crit Care Med 166:403-8. 2002
    ..18 x 10(5) versus 2.84 x 10(5) +/- 0.28 x 10(5) nucleated cells/ml; p = 0.021), and injury score (7.0 +/- 3.3 versus 0.7 +/- 0.9; p < 0.0001). We conclude that hypercapnic acidosis is protective against VILI in this model...
  95. ncbi Pressure/volume curves and lung computed tomography in acute respiratory distress syndrome
    J J Rouby
    Reanimation Chirurgicale Pierre Viars, Dept of Anesthesiology, Hospital Pitié Salpêtrière, University Paris VI, Paris, France
    Eur Respir J Suppl 42:27s-36s. 2003
    ..In such patients, alveolar recruitment resulting from positive end-expiratory pressure >10 cmH2O is preceded and accompanied by lung overinflation...
  96. ncbi Effect of air and heliox as carrier gas on CO2 transport in a model of high-frequency oscillation comparing two oscillators
    Reinout J Mildner
    Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Crit Care Med 31:1759-63. 2003
    ..To study the effect of carrier gas on CO(2) transport during high-frequency oscillatory ventilation in a closed model...
  97. ncbi Repeated derecruitments accentuate lung injury during mechanical ventilation
    Gee Young Suh
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Korea
    Crit Care Med 30:1848-53. 2002
    ..This study was performed to test the hypothesis that derecruitment itself might accentuate lung injury during mechanical ventilation...
  98. ncbi Pulmonary gas exchange response to weaning with pressure-support ventilation in exacerbated chronic obstructive pulmonary disease patients
    Miquel Ferrer
    Servei de Pneumologia i Al lèrgia Respiratoria, Institut Clinic de Pneumologia i Cirurgia Toracica, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, 08036, Barcelona, Spain
    Intensive Care Med 28:1595-9. 2002
    ....
  99. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  100. ncbi The automatic lung parameter estimator (ALPE) system: non-invasive estimation of pulmonary gas exchange parameters in 10-15 minutes
    Stephen Edward Rees
    Center for Model Based Medical Decision Support, Aalborg University, Denmark
    J Clin Monit Comput 17:43-52. 2002
    Clinical measurements of pulmonary gas exchange abnormalities might help prevent hypoxaemia and be useful in monitoring the effects of therapy. In clinical practice single parameters are often used to describe the abnormality e.g...
  101. ncbi Influence of prone position on gastric mucosal-arterial PCO2 gradients
    P Kiefer
    Universitat Ulm, Universitätsklinik für Anästhesiologie, Donau, Germany
    Intensive Care Med 27:1227-30. 2001
    ..To evaluate the effects of mechanical ventilation in the prone position on gastric mucosal-arterial PCO2 gradients...

Research Grants120 found, 100 shown here

  1. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2006
    ..abstract_text> ..
  2. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2005
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. ..
  3. STRESS FAILURE AND REMODELING IN PULMONARY CAPILLARIES
    John West; Fiscal Year: 2002
    ..In addition, at the more basic level, this research is devoted to a fundamental bioengineering dilemma of the lung, namely, that the blood-gas barrier has to combine extreme thinness with immense strength. ..
  4. STRESS FAILURE AND REMODELING IN PULMONARY CAPILLARIES
    John West; Fiscal Year: 2003
    ..In addition, at the more basic level, this research is devoted to a fundamental bioengineering dilemma of the lung, namely, that the blood-gas barrier has to combine extreme thinness with immense strength. ..
  5. STRESS FAILURE AND REMODELING IN PULMONARY CAPILLARIES
    John West; Fiscal Year: 2001
    ..In addition, at the more basic level, this research is devoted to a fundamental bioengineering dilemma of the lung, namely, that the blood-gas barrier has to combine extreme thinness with immense strength. ..
  6. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2006
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  7. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  8. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2002
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  9. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  10. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2007
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  11. The Effect of Pulmonary Interstitial Edema on Gas Exchan
    G Prisk; Fiscal Year: 2006
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  12. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2008
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  13. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  14. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2002
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  15. NON-G DETERMINANTS OF PULMONARY PERFUSION HETEROGENEITY
    Robb Glenny; Fiscal Year: 2000
    ..In addition to this new information on basic lung function, pulmonary perfusion distributions can now be explored in small-animal disease models. ..
  16. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2004
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  17. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2003
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  18. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  19. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  20. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2007
    ..abstract_text> ..
  21. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2008
    ..abstract_text> ..
  22. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  23. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  24. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  25. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2009
    ..abstract_text> ..
  26. REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURY
    Guido Musch; Fiscal Year: 2008
    ..abstract_text> ..
  27. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2010
    ..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..
  28. REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURY
    Guido Musch; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable]..
  29. Novel Strategies Targeting Acute Exacerbation of COPD
    Richard Albert; Fiscal Year: 2003
    ..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
  30. Novel Strategies Targeting Acute Exacerbation of COPD
    Richard Albert; Fiscal Year: 2007
    ..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
  31. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  32. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2000
    ....
  33. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 1999
    ....
  34. Airway Hyper-responsiveness: from molecule to organ
    Merryn Tawhai; Fiscal Year: 2008
    ..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
  35. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..and macrovascular levels, and to thereby provide insight into the mechanisms by which RBCs affect pulmonary gas exchange. The knowledge gained from this project will have health-related ramifications, in that it will allow more ..
  36. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....
  37. Airway Hyper-responsiveness: from molecule to organ
    Merryn Tawhai; Fiscal Year: 2007
    ..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
  38. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2007
    ..and macrovascular levels, and to thereby provide insight into the mechanisms by which RBCs affect pulmonary gas exchange. The knowledge gained from this project will have health-related ramifications, in that it will allow more ..
  39. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2007
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  40. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  41. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2005
    ....
  42. Study of Acid Reflux Therapy for Children with Asthma
    WILLIAM TEAGUE; Fiscal Year: 2007
    ..The results of this trial should have a major impact on the understanding and treatment of GER in children with asthma. ..
  43. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2007
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  44. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2010
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  45. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  46. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2004
    ..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
  47. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2005
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  48. Role of Regulatory T Cells in Chronic Obstructive Pulmonary Disease
    Wissam Chatila; Fiscal Year: 2008
    ....
  49. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2003
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. ..
  50. Cardiovascular Sequellae of Respiratory Muscle Work
    Jerome Dempsey; Fiscal Year: 2008
    ....
  51. Mechanisms of innate immune response modulation by mechanical ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2008
    ....
  52. Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    Chantal Darquenne; Fiscal Year: 2008
    ..The technique developed in the proposed research will also enable future MRI studies of numerous different lung disease models. ..
  53. HUMAN VENTILATORY ADAPTATION
    Jerome Dempsey; Fiscal Year: 1999
    ....
  54. Mitochondrial biogenesis in sepsis-induced organ dysfunction
    KAREN E contact WELTY WOLF; Fiscal Year: 2010
    ..These studies will investigate the role of mitochondrial injury and biogenesis in the pathogenesis of organ dysfunction in sepsis, and should lead to new therapies to enhance recovery from organ failures in sepsis. ..
  55. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 1999
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  56. Mitochondrial biogenesis in sepsis-induced organ dysfunction
    Karen Welty Wolf; Fiscal Year: 2009
    ..These studies will investigate the role of mitochondrial injury and biogenesis in the pathogenesis of organ dysfunction in sepsis, and should lead to new therapies to enhance recovery from organ failures in sepsis. ..
  57. Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
    Machiko Ikegami; Fiscal Year: 2009
    ..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..
  58. PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury
    MARCOS VIDAL MELO; Fiscal Year: 2008
    ..abstract_text> ..
  59. Dynamics of Vascular Microbubbles and Microdroplets in Gas Embolotherapy
    JOSEPH BULL; Fiscal Year: 2007
    ..This approach could potentially be used to treat a variety of cancers and uterine fibroids. ..
  60. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 1999
    ..The goal is to understand the role of SP-D in the cellular and/or structural mechanisms involved in independent regulation of phospholipid and surfactant protein homeostasis. ..
  61. PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury
    MARCOS VIDAL MELO; Fiscal Year: 2009
    ..abstract_text> ..
  62. Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
    Machiko Ikegami; Fiscal Year: 2010
    ..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..
  63. COPD Clinical Research Network & Clinical Research Skills Core Development
    Gerard Criner; Fiscal Year: 2007
    ..abstract_text> ..
  64. CGMP REGULATION IN THE DEVELOPING PULMONARY VASCULATURE
    Robin Steinhorn; Fiscal Year: 2008
    ..To accomplish specific aim 2, we will primarily use in vivo studies to test the hypothesis that scavenging superoxide with rhSOD increases endogenous NO production via changes in NOS expression and/or activity. ..
  65. Dynamics of Vascular Microbubbles and Microdroplets in Gas Embolotherapy
    JOSEPH BULL; Fiscal Year: 2009
    ..This approach could potentially be used to treat a variety of cancers and uterine fibroids. ..
  66. PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury
    Marcos F Vidal Melo; Fiscal Year: 2010
    ..abstract_text> ..
  67. HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGY
    John Torday; Fiscal Year: 2008
    ..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..
  68. Dynamics of Vascular Microbubbles and Microdroplets in Gas Embolotherapy
    JOSEPH BULL; Fiscal Year: 2008
    ..This approach could potentially be used to treat a variety of cancers and uterine fibroids. ..
  69. Sensitive and Specific Molecular Imaging of Pulmonary Nodules
    BASTIAAN contact DRIEHUYS; Fiscal Year: 2010
    ..The proposed research has relevance to public health because new tools in imaging pulmonary cancers will not only improve patient treatment, but will also accelerate research to develop better therapies. ..
  70. Occult Small Vessel Cerebrovascular Disease in High Risk Families
    Paul Nyquist; Fiscal Year: 2009
    ..It is also focused on the genes that may increase the susceptibility to small vessel disease in high risk families with a history of disease. ..
  71. HORMONAL CONTROL OF LUNG DEVELOPMENT--PTHRP BIOLOGY
    John Torday; Fiscal Year: 1999
    ....
  72. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2000
    ..The goal is to understand the role of SP-D in the cellular and/or structural mechanisms involved in independent regulation of phospholipid and surfactant protein homeostasis. ..
  73. Hormonal Control of Lung Development: PTHrP Biology
    John Torday; Fiscal Year: 2002
    ..Understanding these mechanisms will enhance knowledge of normal alveolization and response to injury, and may lead to novel treatments for chronic lung disease in infants. ..
  74. HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGY
    John Torday; Fiscal Year: 2006
    ..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..
  75. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  76. CGMP REGULATION IN THE DEVELOPING PULMONARY VASCULATURE
    Robin Steinhorn; Fiscal Year: 2006
    ..To accomplish specific aim 2, we will primarily use in vivo studies to test the hypothesis that scavenging superoxide with rhSOD increases endogenous NO production via changes in NOS expression and/or activity. ..
  77. Hormonal Control of Lung Development: PTHrP Biology
    John Torday; Fiscal Year: 2003
    ..Understanding these mechanisms will enhance knowledge of normal alveolization and response to injury, and may lead to novel treatments for chronic lung disease in infants. ..
  78. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2003
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  79. Exercise for Mental Health: Does Exercise Make People Feel Better?
    Panteleimon Ekkekakis; Fiscal Year: 2003
    ..The immediate anticipated benefit of this research is the development of physical activity public health recommendations that incorporate affect as a fundamental consideration. ..
  80. Hormonal Control of Lung Development: PTHrP Biology
    John Torday; Fiscal Year: 2003
    ..Understanding these mechanisms will enhance knowledge as to how stem cell function in lung injury/repair, and how they may be used effectively to treat lung injury and chronic lung disease in infants. ..
  81. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2005
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  82. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2005
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. ..
  83. DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURY
    Robert Harris; Fiscal Year: 2005
    ..SA3 will compare local measurements of recruitment by PET with the global measures of recruitment by NO uptake kinetics and lung mechanics. ..
  84. Hormonal Control of Lung Development: PTHrP Biology
    John Torday; Fiscal Year: 2004
    ..Understanding these mechanisms will enhance knowledge of normal alveolization and response to injury, and may lead to novel treatments for chronic lung disease in infants. ..
  85. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  86. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2001
    ..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..