Genomes and Genes
pulmonary gas exchange
Summary: The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Publications267 found, 100 shown here
- Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early deathAnselm K Gitt
Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
Circulation 106:3079-84. 2002..Thus, we compared these parameters with peak VO2 in identifying patients with CHF at increased risk for death within 6 months after evaluation...
- Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchangeS Kjaergaard
Aalborg Hospital, Department of Anaesthesiology, Aalborg, Denmark
Eur J Anaesthesiol 21:296-301. 2004To investigate the clinical application of a mathematical model of pulmonary gas exchange, which ascribes hypoxaemia to shunt and ventilation/perfusion mismatch...
- Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP studyB Koch
Medical Faculty of the Ernst Moritz Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23, D 17475 Greifswald, Germany
Eur Respir J 33:389-97. 2009..While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey...
- The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive casesR Kessler
Department of Pulmonology and Sleep Laboratory, University Hospital, Strasbourg, France
Chest 120:369-76. 2001..We compare also OHS patients with a group of patients with the association of OSAS and COPD, also known as "overlap" patients...
- Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosisSven Glaser
Division of Pulmonary Medicine and Infectious Diseases, University of Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
Respir Med 103:317-24. 2009..The further impairment of exercise capacity as well as the extent of dyspnoea in patients with interceding PHT is attributable to a significantly impaired ventilatory inefficiency...
- Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmaticsN T Tgavalekos
Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
Eur Respir J 29:1174-81. 2007..The current data supports the concept that patchy ventilation is an expression of the integrated system and not just the sum of independent responses of individual airways...
- Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129XeBastiaan Driehuys
Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, NC 27710, USA
Radiology 252:386-93. 2009....
- Pulmonary hypertension in COPDA Chaouat
Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
Eur Respir J 32:1371-85. 2008..In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction...
- Reproducibility of maximal exercise test data in the HERITAGE family studyJ S Skinner
Indiana University, Bloomington, USA
Med Sci Sports Exerc 31:1623-8. 1999..The reproducibility of responses to maximal cycle ergometer testing was determined using data from the HERITAGE Family study at four Clinical Centers in the United States and Canada...
- Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2J P Whiteley
Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
Br J Anaesth 88:771-8. 2002..Measures of impairment of oxygenation can be affected by the inspired oxygen fraction...
- Recruitment and derecruitment during acute respiratory failure: an experimental studyP Pelosi
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:122-30. 2001..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
- Variable tidal volumes improve lung protective ventilation strategies in experimental lung injuryPeter M Spieth
Department of Anesthesiology and Intensive Care Therapy, University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Am J Respir Crit Care Med 179:684-93. 2009..Noisy ventilation with variable Vt may improve respiratory function in acute lung injury...
- Recruitment and derecruitment during acute respiratory failure: a clinical studyS Crotti
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:131-40. 2001..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
- Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitmentJeffrey M Halter
Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
Am J Respir Crit Care Med 167:1620-6. 2003..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
- Probing lung physiology with xenon polarization transfer contrast (XTC)K Ruppert
Department of Radiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Magn Reson Med 44:349-57. 2000..It is further argued that minor pulse-sequence modifications may provide information about the alveolar surface area or lung perfusion...
- High-intensity non-invasive positive pressure ventilation for stable hypercapnic COPDWolfram Windisch
Department of Pneumology, University Hospital Freiburg, Germany
Int J Med Sci 6:72-6. 2009....
- Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injuryStephen P Arold
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Am J Respir Crit Care Med 165:366-71. 2002..05) compared with conventional ventilation. These data indicate that variable ventilation is effective in improving lung function and gas exchange during acute lung injury...
- Perfluorocarbon species and nebulizer type influence aerosolization rate and particle size of perfluorocarbon aerosolMario Rudiger
Clinic for Neonatology, Charite Campus Mitte, Berlin, Germany
J Crit Care 19:42-7. 2004..Aerosolization of perfluorocarbons (PFC) has been proven beneficial in vivo. The present in vitro study was performed to investigate, how PFC-aerosolization is affected by type of nebulizer and PFC properties...
- Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injuryAlysson R Carvalho
Clinic of Anesthesiology and Intensive Care Therapy, Univ Hospital Dresden, Dresden, Germany
J Appl Physiol (1985) 110:1083-92. 2011..Random variation of pressure support further redistributes PBF and improves oxygenation compared with conventional PSV...
- Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPDPierantonio Laveneziana
Respiratory Investigation Unit, Department of Medicine, Kingston General Hospital, Queen s University, 102 Stuart Street, Kingston, ON K7L 2V6, Canada
Eur J Appl Physiol 107:633-43. 2009..cardiodynamic responses and convective oxygen delivery during exercise, resulting in slower ventilatory, pulmonary gas exchange (PGE), and heart rate (HR) kinetics compared with normal...
- Gas exchange modelling: no more gills, pleaseC E W Hahn
Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, UK
Br J Anaesth 91:2-15. 2003
- Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndromeXabier Murgia
Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Bizkaia, Spain
Pediatr Res 72:393-9. 2012..Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated...
- Response-time enhancement of a clinical gas analyzer facilitates measurement of breath-by-breath gas exchangeA D Farmery
Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, United Kingdom
J Appl Physiol (1985) 89:581-9. 2000..With the use of this technique, measurements required for non-steady-state and tidal gas-exchange models can be made easily and reliably in the clinical setting...
- Preoperative gender differences in pulmonary gas exchange in morbidly obese subjectsGerald S Zavorsky
Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, 6420 Clayton Road, Suite 290, Saint Louis, MO 63117, USA
Obes Surg 18:1587-98. 2008Morbidly obese men may have poorer pulmonary gas exchange compared to morbidly obese women (see Zavorsky et al., Chest 131:362-367, 2007)...
- Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findingsT A Altes
Department of Radiology, University of Virginia, Charlottesville, Virginia, USA
J Magn Reson Imaging 13:378-84. 2001..Hyperpolarized 3He lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy...
- Comparison of variable and conventional ventilation in a sheep saline lavage lung injury modelCarissa L Bellardine
Department of Biomedical Engineering, Boston University, Boston, MA, USA
Crit Care Med 34:439-45. 2006..We aimed at testing VV in a large animal lung injury model and exploring the mechanism of improvement in gas exchange seen with VV...
- Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertensionB Rosengarten
Department of Neurology, University Hospital, Justus Liebig University Giessen, Giessen, Germany
Cerebrovasc Dis 21:194-200. 2006..We investigated the impact of these agents on cerebral microcirculatory regulation in patients suffering from this disease...
- Exercise pathophysiology in patients with primary pulmonary hypertensionX G Sun
Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
Circulation 104:429-35. 2001..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
- Cardiac reserve and pulmonary gas exchange kinetics in patients with strokeCorey R Tomczak
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton AB, Canada
Stroke 39:3102-6. 2008..We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects.
- Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humansAndrew T Lovering
Department of Human Physiology, 1240 University of Oregon, Eugene, OR 97403 1240, USA
J Appl Physiol (1985) 104:1418-25. 2008..were made into a peripheral vein at rest and during exercise and recovery (3-5 min postexercise) with pulmonary gas exchange measured simultaneously...
- Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomyAbdulaziz Boker
Department of Anesthesia and Critical Care, Abdulaziz University, Jeddah, Saudi Arabia
Anesthesiology 100:608-16. 2004..VV was compared with CV in patients undergoing abdominal aortic aneurysmectomy, a patient group known to be at risk of deteriorating lung function perioperatively...
- Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflationDenis E O'Donnell
Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Am J Respir Crit Care Med 166:663-8. 2002..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
- Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosisH Olschewski
Depatment of Internal Medicine II, Justus Liebig University, Giessen, Germany
Am J Respir Crit Care Med 160:600-7. 1999..Long-term therapy with inhaled iloprost may be life saving in decompensated right heart failure from pulmonary hypertension secondary to lung fibrosis...
- Acute asthma in adults: a reviewGustavo J Rodrigo
Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
Chest 125:1081-102. 2004..This review describes the epidemiology, costs, pathophysiology, mortality, and management of adult AA in the ED and in the ICU...
- Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balancePhilip N Ainslie
Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
Exp Physiol 95:251-62. 2010..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
- Influence of age, sex, body size, smoking, and beta blockade on key gas exchange exercise parameters in an adult populationSven Glaser
Medical Faculty of the Ernst Moritz Arndt University, Department of Internal Medicine B Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Street 23, D 17475 Greifswald, Germany
Eur J Cardiovasc Prev Rehabil 17:469-76. 2010..This study planned to consider the impact of these factors on CPET values and develop reference equations on the basis of a large-scale population-based survey...
- Additives in intravenous anesthesia modulate pulmonary inflammation in a model of LPS-induced respiratory distressJ J Haitsma
Departments of Anesthesiology, Surgery and Neurosurgery, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA
Acta Anaesthesiol Scand 53:176-82. 2009..In the present study, we hypothesized that pulmonary inflammation could be modulated by propofol with EDTA compared with propofol with sulfite...
- Prevention of atelectasis formation during induction of general anesthesiaMarco Rusca
Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
Anesth Analg 97:1835-9. 2003..005). Atelectasis formation is prevented by application of PEEP during the anesthesia induction despite the use of large oxygen concentrations, resulting in improved oxygenation...
- Design of a new variable-ventilation method optimized for lung recruitment in miceApiradee Thammanomai
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
J Appl Physiol (1985) 104:1329-40. 2008..In addition, variable stretch patterns delivered to the lung by VV can reduce the progression of lung injury due to ventilation in injured mice...
- Quantitative measurement of regional lung ventilation using 3He MRIAnselm J Deninger
Amersham Health R and D, Medeon, SE 205 12 Malmö, Sweden
Magn Reson Med 48:223-32. 2002..The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values...
- Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndromeElena Gastiasoro-Cuesta
Department of Pediatrics, Hospital de Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
Pediatrics 117:295-303. 2006..To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model...
- High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenationDidier Demory
Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
Crit Care Med 35:106-11. 2007..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
- Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patientsW A Almarakbi
Department of Anesthesia, Ain Shams University, Cairo, Egypt
Br J Anaesth 102:862-8. 2009..This study was performed to determine whether repeated lung recruitment combined with PEEP improves respiratory compliance and arterial partial pressure of oxygen (Pa(O2)) in obese patients undergoing laparoscopic gastric banding...
- Influence of exogenous fat emulsion on pulmonary gas exchange after major surgerySouji Sane
First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
World J Surg 26:297-302. 2002..The aim of this study was to evaluate the influence of exogenous fat emulsion on pulmonary gas exchange in the early period after major surgery...
- Video-assisted thoracoscopic surgery does not deteriorate postoperative pulmonary gas exchange in spontaneous pneumothorax patientsY Sekine
Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan
Eur J Cardiothorac Surg 16:48-53. 1999Video-assisted thoracoscopic surgery (VATS) is generally recognized as a less invasive method than thoracotomy. However, the influence of VATS on postoperative pulmonary gas exchange has yet to be evaluated.
- Comparison between the Datex-Ohmeda M-COVX metabolic monitor and the Deltatrac II in mechanically ventilated patientsS McLellan
Department of Anaesthetics, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, Scotland, UK
Intensive Care Med 28:870-6. 2002..To compare the M-COVX and the Deltatrac II metabolic monitors under clinical conditions...
- Determinants of oxygen uptake. Implications for exercise testingD C Poole
Department of Kinesiology, Kansas State University, Manhattan, USA
Sports Med 24:308-20. 1997....
- Validity and reliability of selected commercially available metabolic analyzer systemsL D Hodges
Research Centre for Health Studies, Buckinghamshire Chilterns University College, Buckinghamshire, UK
Scand J Med Sci Sports 15:271-9. 2005..This presents a significant practical challenge in light of the speed with which technical developments in the field occur and we make some suggestions for the formulation of intersystem comparison studies...
- Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injuryA Katz
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Am J Respir Crit Care Med 164:260-4. 2001..Although heliox improved gas exchange during HFOV in our model, increased tidal volume delivery may limit clinical applicability...
- Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humansBruno Grassi
Dipartimento di Scienze e Tecnologie Biomediche, School of Medicine, University of Milan, Milan, Italy
J Appl Physiol (1985) 95:149-58. 2003..The lack of a drop in muscle oxygenation at the transition suggests adequacy of O2 availability in relation to needs...
- Ventilation-perfusion distributions in different porcine lung injury modelsP Neumann
Department of Clinical Physiology, University of Uppsala, Sweden
Acta Anaesthesiol Scand 45:78-86. 2001..Although V(A)/Q distributions can be related to pathogenic aspects of the three study groups, we did not observe specific V(A)/Q patterns which allow diagnosis of the type of lung injury from a recovered V(A)/Q distribution...
- Non-invasive mechanical ventilation in status asthmaticusM M Fernandez
Intensive Care Department, Corporació Sanitària Parc Taulí s n, 08208 Sabadell, Spain
Intensive Care Med 27:486-92. 2001..To evaluate our clinical experience with the use of non-invasive mechanical ventilation (NIMV) in patients with an acute asthmatic attack...
- Is hemoglobin desaturation related to blood viscosity in athletes during exercise?P Connes
UPRES EA 2991 Sport, Performance et Santé, Montpellier, France
Int J Sports Med 25:569-74. 2004..Whether this could impair the blood gas barrier and result in exercise-induced hypoxemia requires further study...
- Improved arterial oxygenation with biologically variable or fractal ventilation using low tidal volumes in a porcine model of acute respiratory distress syndromeAbdulaziz Boker
Department of Anesthesiology, University of Manitoba, Winnipeg, Canada
Am J Respir Crit Care Med 165:456-62. 2002..With V (bv), VT variability demonstrated an inverse power law indicating fractal behavior. In this model of ARDS, V (bv) improved Pa(O(2)) at lower peak airway pressure and IL-8 levels compared with V (c)...
- Determining the best ventilatory efficiency measure to predict mortality in patients with heart failureRobert L Bard
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48106, USA
J Heart Lung Transplant 25:589-95. 2006..Therefore, we investigated the relative prognostic power of different measures of ventilatory efficiency calculated from maximal and sub-maximal exercise in patients with heart failure...
- Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokinesEric K Chu
Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
Crit Care Med 32:168-74. 2004..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
- Spatial and functional relationships between air conduits and blood capillaries in the pulmonary gas exchange tissue of adult and developing chickensAndrew N Makanya
Institute of Anatomy, Department of Medicine, University of Fribourg, Rte Albert Gockel 1, CH 1700, Fribourg, Switzerland
Microsc Res Tech 74:159-69. 2011..Our findings clarify the mode of gas exchange in the parabronchial mantle and illuminate the basis for the functional efficiency of the avian lung...
- Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlandersPeter D Wagner
Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Appl Physiol (1985) 92:1393-400. 2002b>Pulmonary gas exchange and acid-base state were compared in nine Danish lowlanders (L) acclimatized to 5,260 m for 9 wk and seven native Bolivian residents (N) of La Paz (altitude 3,600-4,100 m) brought acutely to this altitude...
- Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertensionZhenguo Zhai
Imperial College School of Medicine, Imperial College London, London, England
Chest 140:1284-91. 2011..Little is known about whether these measures can be applied to all forms of PH, in particular chronic thromboembolic pulmonary hypertension (CTEPH), wherein thrombotic vascular occlusion has an impact on gas exchange...
- Ramp exercise protocols for clinical and cardiopulmonary exercise testingJ Myers
Cardiology Division, Palo Alto VA Health Care System, California 94304, USA
Sports Med 30:23-9. 2000..This article reviews these issues and discusses the evolution of ramp testing which has occurred in the 1990s...
- Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humansRichard B Weiskopf
Department of Anesthesia and Perioperative Care, University of California, San Francisco, Box 0648, San Francisco, CA 94143 0648, USA
Anesth Analg 114:511-9. 2012..We tested the hypothesis that transfusion can cause mild pulmonary dysfunction that has not been noticed clinically and is not sufficiently severe to fit the definition of transfusion-related acute lung injury...
- Topographic basis of bimodal ventilation-perfusion distributions during bronchoconstriction in sheepMarcos F Vidal Melo
Cardiac Anesthesia Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Am J Respir Crit Care Med 171:714-21. 2005..Assessment of the subresolution VA/Q heterogeneity is therefore essential to accurately quantify global gas exchange impairment during bronchoconstriction...
- Performance characteristics of gas analysis systems: what we know and what we need to knowG Atkinson
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
Int J Sports Med 26:S2-10. 2005..We stressed that this judgement should be based on expert-agreed position statements about acceptable error, which unfortunately have yet to be formulated for gas analysis systems...
- A mathematical model of pulmonary gas exchange under inflammatory stressAngela Reynolds
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 264:161-73. 2010....
- A methodology to assess the accuracy of a portable metabolic system (VmaxST)Fabrice Prieur
Laboratoire d Analyse Multidisciplinaire des Pratiques Sportives, UFR STAPS de Liévin, Université d Artois, Lievin, France
Med Sci Sports Exerc 35:879-85. 2003..Validity of a portable metabolic system (VmaxST) was investigated during gas exchanges simulations by a mechanical system (GESS) and during human exercise...
- Effects of spontaneous breathing during airway pressure release ventilation on intestinal blood flow in experimental lung injuryRudolf Hering
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Anesthesiology 99:1137-44. 2003..The authors hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and intestinal blood flow than APRV without SB...
- The prone position results in smaller ventilation defects during bronchoconstriction in asthmaR Scott Harris
Department of Medicine, Pulmonary and Critical Care Unit, Bulfinch 148, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Appl Physiol (1985) 107:266-74. 2009..In asthma, the size and location of ventilation defects is affected by body position and likely affected by small differences in lung expansion during bronchoconstriction...
- Non-invasive estimation of shunt and ventilation-perfusion mismatchSøren Kjaergaard
Department of Anaesthesiology, Aalborg Hospital, Aarhus University Hospitals, 9000 Aalborg, Denmark
Intensive Care Med 29:727-34. 2003To investigate whether parameters describing pulmonary gas exchange (shunt and ventilation-perfusion mismatch) can be estimated consistently by the use of non-invasive data as input to a mathematical model of oxygen transport.
- Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humansNicholas D Giardino
Department of Rehabilitation Medicine, University of Washington, 1959 SE Pacific Street, Seattle, WA 98195, USA
Am J Physiol Heart Circ Physiol 284:H1585-91. 2003Respiratory sinus arrhythmia (RSA) may be associated with improved efficiency of pulmonary gas exchange by matching ventilation to perfusion within each respiratory cycle. Respiration rate, tidal volume, minute ventilation (...
- Exercise-induced intrapulmonary arteriovenous shunting and pulmonary gas exchangeMichael K Stickland
The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1532, USA
Exerc Sport Sci Rev 34:99-106. 2006..intrapulmonary shunt vessels during exercise, which may contribute to the exercise-induced impairment in pulmonary gas exchange. These findings are consistent with substantial anatomical data demonstrating large-diameter (> 25 ..
- Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humansShoji Ito
Department of Anaesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
Exp Physiol 91:935-41. 2006..arrhythmia (RSA) and anatomical dead space volume, respectively, contribute to improve the efficiency of pulmonary gas exchange in humans. We examined the effect of blocking vagal nerve activity with atropine on pulmonary gas exchange...
- Comparison of effects of perflubron and surfactant lung lavage on pulmonary gas exchange in a piglet model of meconium aspirationRolf L Schlosser
Department of Pediatrics, Johann Wolfgang Goethe University Hospital, Frankfurt Main, Germany
Biol Neonate 81:126-31. 2002..Lavage with exogenous surfactant as well as with PFOB improve pulmonary gas exchange in a piglet model of meconium aspiration.
- Cardiopulmonary response to exercise in patients with liver cirrhosis and impaired pulmonary gas exchangeMalcolm Lemyze
Department of Respiratory and Critical Care Medicine, Schaffner Hospital, 99 route de La Bassée, Lens, France
Respir Med 105:1550-6. 2011Maximal exercise capacity and pulmonary gas exchange are both commonly impaired in liver cirrhosis...
- Pressure support compared with controlled mechanical ventilation in experimental lung injuryRolf Dembinski
Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Anesth Analg 94:1570-6, table of contents. 2002..005). We conclude that, in this model of ALI, PSV improves gas exchange because of a reduction of .V(A)/.Q inequality. However, improvements in .V(A)/.Q distribution may be more effective with CMV than with PSV...
- Flow-through respirometry applied to chamber systems: pros and cons, hints and tipsJ R B Lighton
Department of Biology, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154 4004, USA
Comp Biochem Physiol A Mol Integr Physiol 158:265-75. 2011....
- Pulmonary gas exchange is reduced by the cardiovascular diving response in resting humansJohan P A Andersson
Department of Cell and Organism Biology, Lund University, Lund, Sweden
Respir Physiol Neurobiol 160:320-4. 2008..4 ml min(-1)kg(-1)). We conclude that the cardiovascular adjustments of the diving response reduces pulmonary gas exchange in resting humans, allowing longer apneas by preserving the lungs' O(2) store for use by vital organs.
- Relation between PaO2/FIO2 ratio and FIO2: a mathematical descriptionJerome Aboab
Réanimation Médicale, AP HP, Hopital Henri Mondor, 51, av du Maréchal de Lattre de Tassigny, 94010 Creteil, France
Intensive Care Med 32:1494-7. 2006
- Minimal model quantification of pulmonary gas exchange in intensive care patientsDan S Karbing
Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 204, DK 9220 Aalborg East, Denmark
Med Eng Phys 33:240-8. 2011Mathematical models are required to describe pulmonary gas exchange. The challenge remains to find models which are complex enough to describe physiology and simple enough for clinical practice...
- Clinical review: Extracorporeal membrane oxygenationLuciano Gattinoni
Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
Crit Care 15:243. 2011..The current enthusiasm for ECMO in its various aspects should not, however, obscure the consideration of the potential complications associated with this life-saving technique, primarily brain hemorrhage...
- Validity, reliability and stability of the portable Cortex Metamax 3B gas analysis systemD J MacFarlane
Institute of Human Performance, The University of Hong Kong, Pokfulam, Hong Kong
Eur J Appl Physiol 112:2539-47. 2012..It is concluded the MM3B produces acceptably stable and reliable results, but is not adequately valid during moderate and vigorous exercise without some further correction of VO(2) and VCO(2)...
- An experimental rat model of ex vivo lung perfusion for the assessment of lungs after prostacyclin administration: inhaled versus parenteral routesPaulo Francisco Guerreiro Cardoso
Department of Cardiorespiratory Diseases, Thoracic Surgery Section, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
J Bras Pneumol 37:589-97. 2011..To present a model of prostaglandin I2 (PGI2) administration (inhaled vs. parenteral) and to assess the functional performance of the lungs in an ex vivo lung perfusion system...
- Hyperpolarized Xe MR imaging of alveolar gas uptake in humansZackary I Cleveland
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 5:e12192. 2010..However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange...
- Pulmonary gas exchange in the morbidly obeseG S Zavorsky
Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
Obes Rev 9:326-39. 2008The literature on pulmonary gas exchange at rest, during exercise, and with weight loss in the morbidly obese (body mass index or BMI > or = 40 kg m(-2)) is reviewed...
- Pulmonary gas exchange during exercise in pigsS R Hopkins
Department of Medicine, University of California San Diego, La Jolla, California 92093 0623
J Appl Physiol (1985) 86:93-100. 1999..These data suggest that the pig animal model is well suited for studying the mechanism of exercise-induced VA/Q inequality...
- Thin-section CT abnormalities and pulmonary gas exchange impairment in workers exposed to asbestosAndrea Sette
Pulmonary Function and Clinical Exercise Physiology Unit, Div of Respiratory Diseases, Federal Univ of São Paulo, Rua Professor Francisco de Castro 54, Vila Clementino, CEP 04020 050 São Paulo, Brazil
Radiology 232:66-74. 2004To evaluate the relationship between abnormalities at thin-section computed tomography (CT) and indexes of pulmonary gas exchange impairment at rest and during moderate exercise in workers exposed to asbestos.
- Teaching pulmonary gas exchange physiology using computer modelingKent S Kapitan
Division of Pulmonary Medicine, School of Medicine, Southern Illinois University, Springfield, Illinois 62794 9636, USA
Adv Physiol Educ 32:61-4. 2008..To overcome this difficulty, I have developed an interactive computer simulation of pulmonary gas exchange that is web based and allows the student to vary multiple factors simultaneously and observe the final ..
- Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchangeD Torbati
Division Critical Care Medicine, Miami Children s Hospital, FL 33155 3009, USA
Crit Care Med 27:1878-84. 1999..To compare normative ventilatory and gas-exchange data and anesthetic requirements in male and female rats subjected to critical care conditions...
- Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lungG Kim Prisk
Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
J Appl Physiol (1985) 108:53-9. 2010..We hypothesized that infusion would disrupt pulmonary gas exchange by increasing ventilation/perfusion ((.)VA/(...
- Understanding pulmonary gas exchange: ventilation-perfusion relationshipsJohn B West
Am J Physiol Lung Cell Mol Physiol 287:L1071-2. 2004..Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949 (http://ajplegacy.physiology.org/cgi/reprint/158/1/21)). Riley RL...
- Oxygen in air (FiO2 0.4) improves gas exchange in young healthy patients during general anesthesiaAnil Agarwal
Department of Anesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Can J Anaesth 49:1040-3. 2002..higher the O(2) concentration the faster is the development of atelectasis, an important cause of impaired pulmonary gas exchange during general anesthesia (GA). We evaluated the effect of ventilation with 0.4 FiO(2) in air, 0...
- Interactions between heart rate variability and pulmonary gas exchange efficiency in humansPeter Y W Sin
Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
Exp Physiol 95:788-97. 2010..component of heart rate variability (respiratory sinus arrhythmia, RSA) has been associated with improved pulmonary gas exchange efficiency in humans via the apparent clustering and scattering of heart beats in time with the ..
- Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixtureF Staffieri
Section of Critical Care and Anesthesia, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
Equine Vet J 41:747-52. 2009..It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange...
- Validity and reliability of three commercially available breath-by-breath respiratory systemsJames Carter
Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
Eur J Appl Physiol 86:435-41. 2002..8-45.8%). The exercise study showed the Oxycon Pro and Oxycon Alpha to be both valid and reliable on-line systems for the measurement of parameters of respiration, at least at workloads up to 150 W...
- Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilationY Imai
Pathophysiology Research Laboratory, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8509, Japan
J Appl Physiol 91:1836-44. 2001..Conventional mechanical ventilation using lung protection strategies (low V(T) high PEEP) only attenuated the decrease in oxygenation and pulmonary compliance. Therefore, HFOV may be a preferable option as a lung protection strategy...
- Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertensionIsabel Blanco
Department of Pulmonary Medicine, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona
Am J Respir Crit Care Med 181:270-8. 2010..However, vasodilators may inhibit hypoxic pulmonary vasoconstriction and impair gas exchange in this condition...
- Systematic review of noninvasive positive pressure ventilation in severe stable COPDM A Kolodziej
Dept of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospitals, University of Alberta, Edmonton, AB, Canada
Eur Respir J 30:293-306. 2007....
- Prone positioning improves oxygenation in post-traumatic lung injury--a prospective randomized trialGregor Voggenreiter
Department of Trauma Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
J Trauma 59:333-41; discussion 341-3. 2005..In a prospective randomized trial the effect of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients and was compared with patients ventilated in supine position...
- Intercomparison of recruitment maneuver efficacy in three models of acute lung injurySung Chul Lim
Department of Pulmonary Critical Care Medicine, Regions Hospital, University of Minnesota, St Paul, MN, USA
Crit Care Med 32:2371-7. 2004..To compare the relative efficacy of three forms of recruitment maneuvers in diverse models of acute lung injury characterized by differing pathoanatomy...
- Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndromeAnne Hilgendorff
Department of Pediatrics and Neonatology, Justus Liebig University Giessen, Germany
Crit Care Med 34:203-10. 2006..remains a relevant cause of neonatal respiratory failure and is characterized by severe impairment of pulmonary gas exchange, surfactant inactivation, and pronounced inflammatory changes...
- Bench-to-bedside review: Recruitment and recruiting maneuversStephen E Lapinsky
Intensive Care Unit, Mount Sinai Hospital, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
Crit Care 9:60-5. 2005..In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique...
- Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosisRichard Kraemer
Department of Paediatrics, University of Berne, Inselspital CH 3010 Berne, Switzerland
Respir Res 7:138. 2006....
- Integrity of the Pulmonary Blood-Gas BarrierJohn West; Fiscal Year: 2007..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
- Deposition of 0.5 to 2 Micron Aerosol in the Human LungG Prisk; Fiscal Year: 2003..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
- The Effect of Pulmonary Interstitial Edema on Gas ExchangeG Prisk; Fiscal Year: 2009..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
- Pulmonary Vascular Tree Development, Growth & RemodlingRobb Glenny; Fiscal Year: 2005..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
- Lung Perfusion Heterogeneity and Mechanisms of EdemaSusan R Hopkins; Fiscal Year: 2010..abstract_text> ..
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2008..abstract_text> ..
- Regional Hypoxic Pulmonary VasoconstrictionMICHAEL HLASTALA; Fiscal Year: 2006..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
- Novel Strategies Targeting Acute Exacerbation of COPDRichard Albert; Fiscal Year: 2007..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
- MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFERDavid Poole; Fiscal Year: 2001....
- Red Blood Cells, Nitric Oxide and Pulmonary CirculationSteven Deem; Fiscal Year: 2008..and macrovascular levels, and to thereby provide insight into the mechanisms by which RBCs affect pulmonary gas exchange. The knowledge gained from this project will have health-related ramifications, in that it will allow more ..
- HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLSSteven Deem; Fiscal Year: 2002....
- Exercise for Mental Health: Does Exercise Make People Feel Better?Panteleimon Ekkekakis; Fiscal Year: 2003..The immediate anticipated benefit of this research is the development of physical activity public health recommendations that incorporate affect as a fundamental consideration. ..
- Surrogate markers for Severe Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2005..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
- Molecular imaging using hyperpolarized carbon-13Stephen Kadlecek; Fiscal Year: 2007..Key Words: Polarized Carbon-13 MRI; Metabolic imaging; Molecular imaging. [unreadable] [unreadable] [unreadable]..
- Modeling of Aerosol Transport in Alveolated AirwaysChantal Darquenne; Fiscal Year: 2009..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
- INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASEJohn Kinsella; Fiscal Year: 2004..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
- Expired CO2/O2 Analysis to Diagnose Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2008..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
- Immunomodulatory Effects of Mechanical VentilationWILLIAM ALTEMEIER; Fiscal Year: 2007....
- CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIESJerome Dempsey; Fiscal Year: 2002..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
- Stretch and Vitamin A Effects on Alveolar FormationKURT ALBERTINE; Fiscal Year: 2009..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
- Pretest Probability Assessment for Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2005..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
- Neural Mechanisms in Congestive Heart FailureGLENN TONEY; Fiscal Year: 2007..This information will yeild new and potentially important insight into the processes that lead to sympathetic activation and progression of disease severity in CHF. ..
- Particles in Developing Lung: Bioengineering ApproachAkira Tsuda; Fiscal Year: 2007..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
- Arterial Stiffness & Age-Effects on Circulatory ControlJ Taylor; Fiscal Year: 2007..We seek renewed funding to examine fully sympatho-vagal interactions with age and disease and prospectively assess the effects of exercise. ..
- Integrative Models of Neural Adaptive ControlChi Sang Poon; Fiscal Year: 2007..unreadable] [unreadable]..
- Physical Activity Assessment Using Variability in Accelerometer CountsDavid Bassett; Fiscal Year: 2007..The improved method could then be used in future studies of the relationships between physical activity and health outcomes. [unreadable] [unreadable] [unreadable]..
- Physical Work Capacity After Traumatic Brain InjuryKURT MOSSBERG; Fiscal Year: 2009..The latter is of particular importance from a public health perspective since the individual with TBI is usually young and will endure the permanent disabling effects of TBI for many years. ..
- Micromechanics of the airway smooth muscle cellJeffrey Fredberg; Fiscal Year: 2009..Dalhousie, addressing imaging systems and CSK remodeling;Daniel Navajas, Lead Investigator, U. Barcelona, addressing cell stretch. ..
- PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEACAROLE MARCUS; Fiscal Year: 2008..These studies will help elucidate the pathophysiology of OSAS in obese adolescents, ultimately resulting in improved management of this disease. ..
- Contributions of sleep/rhythms/fatigue to "chemobrain"Sonia Ancoli Israel; Fiscal Year: 2009..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..
- Sympathetic Nervous System & Metabolism in Older HumansChristopher Bell; Fiscal Year: 2008..abstract_text> ..
- TGF BETA RECEPTOR DYNAMICSEdward Leof; Fiscal Year: 2008..Answers to these questions are critical if the processes mediating the various cellular phenotypes induced by TGF-beta are to be elucidated. ..
- High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac SurgeryDean Andropoulos; Fiscal Year: 2008..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
- C-Reactive Protein in Extremely Low Birth Weight NeonatesNamasivayam Ambalavanan; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Programmed adiposity: genetic in utero and postnatal determinantsEric Zorrilla; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Exhaled Nitric Oxide: Mechanisms and LimitationsSTEVEN CARL GEORGE; Fiscal Year: 2010..Understanding the source of exhaled nitric oxide may significantly impact the clinical management of the disease. ..
- PLEURAL LIQUID EXCHANGE AND LUNG MECHANICSSTEPHEN LAI FOOK; Fiscal Year: 2007..A specific objective is to develop a method to separate passive from active transport properties of pericardium and diaphragm, tissues that have both mesothelium and interstitium. ..
- Nonesterified Fatty Acids and Cardiovascular AgingJ Taylor; Fiscal Year: 2006..This work is clinically relevant because these associations may provide insight into the etiology of the increased incidence of cardiovascular disease with age. ..
- FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCERSonia Ancoli Israel; Fiscal Year: 2004..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
- Respiratory activities of intrinsic tongue musclesE Bailey; Fiscal Year: 2004....
- PULMONARY INTERSTITIAL MECHANICSSTEPHEN LAI FOOK; Fiscal Year: 2004..lungs. These studies will measure steric exclusion of albumin in interstitial cuffs of vessels ranging from arterioles to large vessels. ..
- REGULATION OF NUTRIENT METABOLISM IN MALES AND FEMALESTRACY HORTON; Fiscal Year: 2004..These studies will further our understanding of the metabolic basis for disease in males and females and begin to identify gender specific effects of interventions. ..
- VOLTAGE-GATED PROTON CHANNELS IN ALVEOLAR EPITHELIUMTHOMAS DECOURSEY; Fiscal Year: 2003..Demonstration that H+ current fluctuations result from stochastic gating of H+ channels will provide strong evidence that the molecule is an ion channel rather than a carrier. ..
- Role of Estrogen in Exercise-Induced VEGF ExpressionPauline Entin; Fiscal Year: 2003..The results of this study will contribute to the assessment of the risk/benefit ratio for hormone replacement therapy, particularly in the context of those at risk for cardiovascular disease. ..
- OPTIMIZED 3D SPIN-ECHO MR IMAGING OF THE CNSJohn Mugler; Fiscal Year: 2002....
- SLEEP AND ENTERTAIMENT OF SCN FUNCTIONKingman Strohl; Fiscal Year: 2002..abstract_text> ..
- SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERSKingman Strohl; Fiscal Year: 2002..We will disseminate of educational assessments, patient-oriented material, and clinical pathways through local and national consultants in both the public and private sector, as well as through interaction with other awardees. ..
- INSULIN SENSITIVITY IN NON-OBESE SUBJECTSBakary Sonko; Fiscal Year: 2002..S. population. The investigator does not have a major grant and the awarding of this grant will help him to generate the necessary data to allow him to apply for such a grant. This will be a significant burst to his career development. ..
- SYNAPTIC MECHANISMS IN RESPIRATORY CONTROLChi Sang Poon; Fiscal Year: 2002..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
- GENDER AND MENOPAUSE ON NUTRIENT AND ENERGY METABOLISMTRACY HORTON; Fiscal Year: 2001..These studies will further our understanding of the metabolic basis for disease risk in males and females. ..
- REGULATION OF PULMONARY ENDOTHELIAL PERMEABILITYMary Townsley; Fiscal Year: 2002..Fura PE3, a ratiometric dye, will be used to measure Ca2+ transients, while patch clamp techniques will allow direct measurement of store operated Ca2+ channel activity. ..
- BioMediator: Biologic Data Integration& Analysis SystemPeter Tarczy Hornoch; Fiscal Year: 2005..abstract_text> ..
- Xth Oxford Conference on Modeling and Control of BreathingChi Sang Poon; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Role of the CRF2 Receptor in Ingestive BehaviorEric Zorrilla; Fiscal Year: 2005..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
- Discovery of biomarkers of pulmonary hypertensionRubin Tuder; Fiscal Year: 2005..abstract_text> ..
- Dermatopharmacokinetics: In Vivo Analysis of SolventsKarla Thrall; Fiscal Year: 2005..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
- Ventilator-Induced Lung Injury:Mechanisms & ConsequencesScott Sinclair; Fiscal Year: 2005..Aim 3A: Document cyclical airway collapse and reopening via changes in regional ventilation distribution. Aim 3B: Validate a method to estimate appropriate PEEP level to prevent cyclical airway collapse. ..
- Development of a Novel Gas Embolotherapy TechniqueJOSEPH BULL; Fiscal Year: 2005..The proposed research is an essential first step in developing this potentially revolutionary technique. ..
- Lungs Pathology Detection Using Hyperpolarized 129XeKai Ruppert; Fiscal Year: 2006..Finally, the performance of the optimized NMR pulse sequence techniques will be evaluated by detecting and monitoring the development of emphysema in a rabbit model. [unreadable] [unreadable]..
- ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASISMachiko Ikegami; Fiscal Year: 2006..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
- COPD Clinical Research Network & Clinical Research Skills Core DevelopmentGerard Criner; Fiscal Year: 2007..abstract_text> ..
- DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURYRobert Harris; Fiscal Year: 2005..SA3 will compare local measurements of recruitment by PET with the global measures of recruitment by NO uptake kinetics and lung mechanics. ..
- HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGYJohn Torday; Fiscal Year: 2009..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..