Genomes and Genes
pulmonary gas exchange
Summary: The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Publications240 found, 100 shown here
- Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early deathAnselm K Gitt
Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
Circulation 106:3079-84. 2002..Thus, we compared these parameters with peak VO2 in identifying patients with CHF at increased risk for death within 6 months after evaluation...
- Reproducibility of maximal exercise test data in the HERITAGE family studyJ S Skinner
Indiana University, Bloomington, USA
Med Sci Sports Exerc 31:1623-8. 1999..The reproducibility of responses to maximal cycle ergometer testing was determined using data from the HERITAGE Family study at four Clinical Centers in the United States and Canada...
- Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmaticsN T Tgavalekos
Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
Eur Respir J 29:1174-81. 2007..The current data supports the concept that patchy ventilation is an expression of the integrated system and not just the sum of independent responses of individual airways...
- Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129XeBastiaan Driehuys
Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, NC 27710, USA
Radiology 252:386-93. 2009....
- Pulmonary hypertension in COPDA Chaouat
Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
Eur Respir J 32:1371-85. 2008..In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction...
- Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2J P Whiteley
Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
Br J Anaesth 88:771-8. 2002..Measures of impairment of oxygenation can be affected by the inspired oxygen fraction...
- Recruitment and derecruitment during acute respiratory failure: an experimental studyP Pelosi
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:122-30. 2001..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
- Probing lung physiology with xenon polarization transfer contrast (XTC)K Ruppert
Department of Radiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Magn Reson Med 44:349-57. 2000..It is further argued that minor pulse-sequence modifications may provide information about the alveolar surface area or lung perfusion...
- Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertensionB Rosengarten
Department of Neurology, University Hospital, Justus Liebig University Giessen, Giessen, Germany
Cerebrovasc Dis 21:194-200. 2006..We investigated the impact of these agents on cerebral microcirculatory regulation in patients suffering from this disease...
- Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflationDenis E O'Donnell
Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Am J Respir Crit Care Med 166:663-8. 2002..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
- Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findingsT A Altes
Department of Radiology, University of Virginia, Charlottesville, Virginia, USA
J Magn Reson Imaging 13:378-84. 2001..Hyperpolarized 3He lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy...
- Validity and reliability of selected commercially available metabolic analyzer systemsL D Hodges
Research Centre for Health Studies, Buckinghamshire Chilterns University College, Buckinghamshire, UK
Scand J Med Sci Sports 15:271-9. 2005..This presents a significant practical challenge in light of the speed with which technical developments in the field occur and we make some suggestions for the formulation of intersystem comparison studies...
- Preoperative gender differences in pulmonary gas exchange in morbidly obese subjectsGerald S Zavorsky
Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, 6420 Clayton Road, Suite 290, Saint Louis, MO 63117, USA
Obes Surg 18:1587-98. 2008Morbidly obese men may have poorer pulmonary gas exchange compared to morbidly obese women (see Zavorsky et al., Chest 131:362-367, 2007)...
- Comparison of variable and conventional ventilation in a sheep saline lavage lung injury modelCarissa L Bellardine
Department of Biomedical Engineering, Boston University, Boston, MA, USA
Crit Care Med 34:439-45. 2006..We aimed at testing VV in a large animal lung injury model and exploring the mechanism of improvement in gas exchange seen with VV...
- Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertensionZhenguo Zhai
Imperial College School of Medicine, Imperial College London, London, England
Chest 140:1284-91. 2011..Little is known about whether these measures can be applied to all forms of PH, in particular chronic thromboembolic pulmonary hypertension (CTEPH), wherein thrombotic vascular occlusion has an impact on gas exchange...
- Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemiaA J Rice
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000
J Appl Physiol (1985) 87:1802-12. 1999..95, P < 0.001). These data suggest that EIH has a multifactorial etiology related to DL(O(2)), VA/Q inequality, and ventilation...
- Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP studyB Koch
Medical Faculty of the Ernst Moritz Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23, D 17475 Greifswald, Germany
Eur Respir J 33:389-97. 2009..While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey...
- Exercise pathophysiology in patients with primary pulmonary hypertensionX G Sun
Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
Circulation 104:429-35. 2001..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
- Cardiac reserve and pulmonary gas exchange kinetics in patients with strokeCorey R Tomczak
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton AB, Canada
Stroke 39:3102-6. 2008..We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects.
- Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosisH Olschewski
Depatment of Internal Medicine II, Justus Liebig University, Giessen, Germany
Am J Respir Crit Care Med 160:600-7. 1999..Long-term therapy with inhaled iloprost may be life saving in decompensated right heart failure from pulmonary hypertension secondary to lung fibrosis...
- Acute asthma in adults: a reviewGustavo J Rodrigo
Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
Chest 125:1081-102. 2004..This review describes the epidemiology, costs, pathophysiology, mortality, and management of adult AA in the ED and in the ICU...
- Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokinesEric K Chu
Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
Crit Care Med 32:168-74. 2004..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
- Prevention of atelectasis formation during induction of general anesthesiaMarco Rusca
Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
Anesth Analg 97:1835-9. 2003..005). Atelectasis formation is prevented by application of PEEP during the anesthesia induction despite the use of large oxygen concentrations, resulting in improved oxygenation...
- The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive casesR Kessler
Department of Pulmonology and Sleep Laboratory, University Hospital, Strasbourg, France
Chest 120:369-76. 2001..We compare also OHS patients with a group of patients with the association of OSAS and COPD, also known as "overlap" patients...
- Quantitative measurement of regional lung ventilation using 3He MRIAnselm J Deninger
Amersham Health R and D, Medeon, SE 205 12 Malmö, Sweden
Magn Reson Med 48:223-32. 2002..The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values...
- Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndromeElena Gastiasoro-Cuesta
Department of Pediatrics, Hospital de Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
Pediatrics 117:295-303. 2006..To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model...
- Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patientsW A Almarakbi
Department of Anesthesia, Ain Shams University, Cairo, Egypt
Br J Anaesth 102:862-8. 2009..This study was performed to determine whether repeated lung recruitment combined with PEEP improves respiratory compliance and arterial partial pressure of oxygen (Pa(O2)) in obese patients undergoing laparoscopic gastric banding...
- High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenationDidier Demory
Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
Crit Care Med 35:106-11. 2007..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
- Influence of exogenous fat emulsion on pulmonary gas exchange after major surgerySouji Sane
First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
World J Surg 26:297-302. 2002..The aim of this study was to evaluate the influence of exogenous fat emulsion on pulmonary gas exchange in the early period after major surgery...
- Sigh in supine and prone position during acute respiratory distress syndromePaolo Pelosi
Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Ospedale di Circolo, Fondazione Macchi, Varese
Am J Respir Crit Care Med 167:521-7. 2003..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
- Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchangeS Kjaergaard
Aalborg Hospital, Department of Anaesthesiology, Aalborg, Denmark
Eur J Anaesthesiol 21:296-301. 2004To investigate the clinical application of a mathematical model of pulmonary gas exchange, which ascribes hypoxaemia to shunt and ventilation/perfusion mismatch...
- Pulmonary gas exchange is reduced by the cardiovascular diving response in resting humansJohan P A Andersson
Department of Cell and Organism Biology, Lund University, Lund, Sweden
Respir Physiol Neurobiol 160:320-4. 2008..4 ml min(-1)kg(-1)). We conclude that the cardiovascular adjustments of the diving response reduces pulmonary gas exchange in resting humans, allowing longer apneas by preserving the lungs' O(2) store for use by vital organs.
- Pulmonary gas exchange in the morbidly obeseG S Zavorsky
Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
Obes Rev 9:326-39. 2008The literature on pulmonary gas exchange at rest, during exercise, and with weight loss in the morbidly obese (body mass index or BMI > or = 40 kg m(-2)) is reviewed...
- Performance characteristics of gas analysis systems: what we know and what we need to knowG Atkinson
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
Int J Sports Med 26:S2-10. 2005..We stressed that this judgement should be based on expert-agreed position statements about acceptable error, which unfortunately have yet to be formulated for gas analysis systems...
- Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injuryStephen P Arold
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
Am J Respir Crit Care Med 165:366-71. 2002..05) compared with conventional ventilation. These data indicate that variable ventilation is effective in improving lung function and gas exchange during acute lung injury...
- Perfluorocarbon species and nebulizer type influence aerosolization rate and particle size of perfluorocarbon aerosolMario Rudiger
Clinic for Neonatology, Charite Campus Mitte, Berlin, Germany
J Crit Care 19:42-7. 2004..Aerosolization of perfluorocarbons (PFC) has been proven beneficial in vivo. The present in vitro study was performed to investigate, how PFC-aerosolization is affected by type of nebulizer and PFC properties...
- Exercise-induced intrapulmonary arteriovenous shunting and pulmonary gas exchangeMichael K Stickland
The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1532, USA
Exerc Sport Sci Rev 34:99-106. 2006..intrapulmonary shunt vessels during exercise, which may contribute to the exercise-induced impairment in pulmonary gas exchange. These findings are consistent with substantial anatomical data demonstrating large-diameter (> 25 ..
- Effects of spontaneous breathing during airway pressure release ventilation on intestinal blood flow in experimental lung injuryRudolf Hering
Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Anesthesiology 99:1137-44. 2003..The authors hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and intestinal blood flow than APRV without SB...
- Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humansShoji Ito
Department of Anaesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
Exp Physiol 91:935-41. 2006..arrhythmia (RSA) and anatomical dead space volume, respectively, contribute to improve the efficiency of pulmonary gas exchange in humans. We examined the effect of blocking vagal nerve activity with atropine on pulmonary gas exchange...
- Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humansNicholas D Giardino
Department of Rehabilitation Medicine, University of Washington, 1959 SE Pacific Street, Seattle, WA 98195, USA
Am J Physiol Heart Circ Physiol 284:H1585-91. 2003Respiratory sinus arrhythmia (RSA) may be associated with improved efficiency of pulmonary gas exchange by matching ventilation to perfusion within each respiratory cycle. Respiration rate, tidal volume, minute ventilation (...
- Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitmentJeffrey M Halter
Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
Am J Respir Crit Care Med 167:1620-6. 2003..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
- Relation between PaO2/FIO2 ratio and FIO2: a mathematical descriptionJerome Aboab
Réanimation Médicale, AP HP, Hopital Henri Mondor, 51, av du Maréchal de Lattre de Tassigny, 94010 Creteil, France
Intensive Care Med 32:1494-7. 2006
- Non-invasive estimation of shunt and ventilation-perfusion mismatchSøren Kjaergaard
Department of Anaesthesiology, Aalborg Hospital, Aarhus University Hospitals, 9000 Aalborg, Denmark
Intensive Care Med 29:727-34. 2003To investigate whether parameters describing pulmonary gas exchange (shunt and ventilation-perfusion mismatch) can be estimated consistently by the use of non-invasive data as input to a mathematical model of oxygen transport.
- A methodology to assess the accuracy of a portable metabolic system (VmaxST)Fabrice Prieur
Laboratoire d Analyse Multidisciplinaire des Pratiques Sportives, UFR STAPS de Liévin, Université d Artois, Lievin, France
Med Sci Sports Exerc 35:879-85. 2003..Validity of a portable metabolic system (VmaxST) was investigated during gas exchanges simulations by a mechanical system (GESS) and during human exercise...
- Topographic basis of bimodal ventilation-perfusion distributions during bronchoconstriction in sheepMarcos F Vidal Melo
Cardiac Anesthesia Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Am J Respir Crit Care Med 171:714-21. 2005..Assessment of the subresolution VA/Q heterogeneity is therefore essential to accurately quantify global gas exchange impairment during bronchoconstriction...
- The prone position results in smaller ventilation defects during bronchoconstriction in asthmaR Scott Harris
Department of Medicine, Pulmonary and Critical Care Unit, Bulfinch 148, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Appl Physiol (1985) 107:266-74. 2009..In asthma, the size and location of ventilation defects is affected by body position and likely affected by small differences in lung expansion during bronchoconstriction...
- Flow-through respirometry applied to chamber systems: pros and cons, hints and tipsJ R B Lighton
Department of Biology, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154 4004, USA
Comp Biochem Physiol A Mol Integr Physiol 158:265-75. 2011....
- Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injuryAlysson R Carvalho
Clinic of Anesthesiology and Intensive Care Therapy, Univ Hospital Dresden, Dresden, Germany
J Appl Physiol (1985) 110:1083-92. 2011..Random variation of pressure support further redistributes PBF and improves oxygenation compared with conventional PSV...
- Minimal model quantification of pulmonary gas exchange in intensive care patientsDan S Karbing
Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 204, DK 9220 Aalborg East, Denmark
Med Eng Phys 33:240-8. 2011Mathematical models are required to describe pulmonary gas exchange. The challenge remains to find models which are complex enough to describe physiology and simple enough for clinical practice...
- Cardiopulmonary response to exercise in patients with liver cirrhosis and impaired pulmonary gas exchangeMalcolm Lemyze
Department of Respiratory and Critical Care Medicine, Schaffner Hospital, 99 route de La Bassée, Lens, France
Respir Med 105:1550-6. 2011Maximal exercise capacity and pulmonary gas exchange are both commonly impaired in liver cirrhosis...
- An experimental rat model of ex vivo lung perfusion for the assessment of lungs after prostacyclin administration: inhaled versus parenteral routesPaulo Francisco Guerreiro Cardoso
Department of Cardiorespiratory Diseases, Thoracic Surgery Section, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
J Bras Pneumol 37:589-97. 2011..To present a model of prostaglandin I2 (PGI2) administration (inhaled vs. parenteral) and to assess the functional performance of the lungs in an ex vivo lung perfusion system...
- Comparison of effects of perflubron and surfactant lung lavage on pulmonary gas exchange in a piglet model of meconium aspirationRolf L Schlosser
Department of Pediatrics, Johann Wolfgang Goethe University Hospital, Frankfurt Main, Germany
Biol Neonate 81:126-31. 2002..Lavage with exogenous surfactant as well as with PFOB improve pulmonary gas exchange in a piglet model of meconium aspiration.
- Pressure support compared with controlled mechanical ventilation in experimental lung injuryRolf Dembinski
Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Anesth Analg 94:1570-6, table of contents. 2002..005). We conclude that, in this model of ALI, PSV improves gas exchange because of a reduction of .V(A)/.Q inequality. However, improvements in .V(A)/.Q distribution may be more effective with CMV than with PSV...
- Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndromeXabier Murgia
Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Bizkaia, Spain
Pediatr Res 72:393-9. 2012..Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated...
- A mathematical model of pulmonary gas exchange under inflammatory stressAngela Reynolds
Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Theor Biol 264:161-73. 2010....
- Validity, reliability and stability of the portable Cortex Metamax 3B gas analysis systemD J MacFarlane
Institute of Human Performance, The University of Hong Kong, Pokfulam, Hong Kong
Eur J Appl Physiol 112:2539-47. 2012..It is concluded the MM3B produces acceptably stable and reliable results, but is not adequately valid during moderate and vigorous exercise without some further correction of VO(2) and VCO(2)...
- Clinical review: Extracorporeal membrane oxygenationLuciano Gattinoni
Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
Crit Care 15:243. 2011..The current enthusiasm for ECMO in its various aspects should not, however, obscure the consideration of the potential complications associated with this life-saving technique, primarily brain hemorrhage...
- Hyperpolarized Xe MR imaging of alveolar gas uptake in humansZackary I Cleveland
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 5:e12192. 2010..However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange...
- Influence of a vital capacity maneuver on pulmonary gas exchange after cardiopulmonary bypassG S Murphy
Departments of Anesthesia and Surgery, Evanston Northwestern Healthcare/Northwestern University, Evanston, IL, USA
J Cardiothorac Vasc Anesth 15:336-40. 2001..breath (vital capacity maneuver [VCM]), administered at the end of cardiopulmonary bypass (CPB), on pulmonary gas exchange in patients undergoing coronary artery bypass graft surgery...
- Interactions between heart rate variability and pulmonary gas exchange efficiency in humansPeter Y W Sin
Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
Exp Physiol 95:788-97. 2010..component of heart rate variability (respiratory sinus arrhythmia, RSA) has been associated with improved pulmonary gas exchange efficiency in humans via the apparent clustering and scattering of heart beats in time with the ..
- Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchangeD Torbati
Division Critical Care Medicine, Miami Children s Hospital, FL 33155 3009, USA
Crit Care Med 27:1878-84. 1999..To compare normative ventilatory and gas-exchange data and anesthetic requirements in male and female rats subjected to critical care conditions...
- Pulmonary gas exchange during exercise in pigsS R Hopkins
Department of Medicine, University of California San Diego, La Jolla, California 92093 0623
J Appl Physiol (1985) 86:93-100. 1999..These data suggest that the pig animal model is well suited for studying the mechanism of exercise-induced VA/Q inequality...
- Thin-section CT abnormalities and pulmonary gas exchange impairment in workers exposed to asbestosAndrea Sette
Pulmonary Function and Clinical Exercise Physiology Unit, Div of Respiratory Diseases, Federal Univ of São Paulo, Rua Professor Francisco de Castro 54, Vila Clementino, CEP 04020 050 São Paulo, Brazil
Radiology 232:66-74. 2004To evaluate the relationship between abnormalities at thin-section computed tomography (CT) and indexes of pulmonary gas exchange impairment at rest and during moderate exercise in workers exposed to asbestos.
- Understanding pulmonary gas exchange: ventilation-perfusion relationshipsJohn B West
Am J Physiol Lung Cell Mol Physiol 287:L1071-2. 2004..Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949 (http://ajplegacy.physiology.org/cgi/reprint/158/1/21)). Riley RL...
- Influence of age, sex, body size, smoking, and beta blockade on key gas exchange exercise parameters in an adult populationSven Glaser
Medical Faculty of the Ernst Moritz Arndt University, Department of Internal Medicine B Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Street 23, D 17475 Greifswald, Germany
Eur J Cardiovasc Prev Rehabil 17:469-76. 2010..This study planned to consider the impact of these factors on CPET values and develop reference equations on the basis of a large-scale population-based survey...
- Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixtureF Staffieri
Section of Critical Care and Anesthesia, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
Equine Vet J 41:747-52. 2009..It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange...
- Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balancePhilip N Ainslie
Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
Exp Physiol 95:251-62. 2010..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
- Oxygen in air (FiO2 0.4) improves gas exchange in young healthy patients during general anesthesiaAnil Agarwal
Department of Anesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Can J Anaesth 49:1040-3. 2002..higher the O(2) concentration the faster is the development of atelectasis, an important cause of impaired pulmonary gas exchange during general anesthesia (GA). We evaluated the effect of ventilation with 0.4 FiO(2) in air, 0...
- Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humansAndrew T Lovering
Department of Human Physiology, 1240 University of Oregon, Eugene, OR 97403 1240, USA
J Appl Physiol (1985) 104:1418-25. 2008..were made into a peripheral vein at rest and during exercise and recovery (3-5 min postexercise) with pulmonary gas exchange measured simultaneously...
- Teaching pulmonary gas exchange physiology using computer modelingKent S Kapitan
Division of Pulmonary Medicine, School of Medicine, Southern Illinois University, Springfield, Illinois 62794 9636, USA
Adv Physiol Educ 32:61-4. 2008..To overcome this difficulty, I have developed an interactive computer simulation of pulmonary gas exchange that is web based and allows the student to vary multiple factors simultaneously and observe the final ..
- Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lungG Kim Prisk
Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
J Appl Physiol (1985) 108:53-9. 2010..We hypothesized that infusion would disrupt pulmonary gas exchange by increasing ventilation/perfusion ((.)VA/(...
- Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertensionIsabel Blanco
Department of Pulmonary Medicine, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona
Am J Respir Crit Care Med 181:270-8. 2010..However, vasodilators may inhibit hypoxic pulmonary vasoconstriction and impair gas exchange in this condition...
- Systematic review of noninvasive positive pressure ventilation in severe stable COPDM A Kolodziej
Dept of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospitals, University of Alberta, Edmonton, AB, Canada
Eur Respir J 30:293-306. 2007....
- Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilationY Imai
Pathophysiology Research Laboratory, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8509, Japan
J Appl Physiol 91:1836-44. 2001..Conventional mechanical ventilation using lung protection strategies (low V(T) high PEEP) only attenuated the decrease in oxygenation and pulmonary compliance. Therefore, HFOV may be a preferable option as a lung protection strategy...
- Prone positioning improves oxygenation in post-traumatic lung injury--a prospective randomized trialGregor Voggenreiter
Department of Trauma Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
J Trauma 59:333-41; discussion 341-3. 2005..In a prospective randomized trial the effect of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients and was compared with patients ventilated in supine position...
- Intercomparison of recruitment maneuver efficacy in three models of acute lung injurySung Chul Lim
Department of Pulmonary Critical Care Medicine, Regions Hospital, University of Minnesota, St Paul, MN, USA
Crit Care Med 32:2371-7. 2004..To compare the relative efficacy of three forms of recruitment maneuvers in diverse models of acute lung injury characterized by differing pathoanatomy...
- Validity of inspiratory and expiratory methods of measuring gas exchange with a computerized systemD R Bassett
Department of Exercise Science and Sport Management, University of Tennessee, Knoxville, Tennessee 37996 2700, USA
J Appl Physiol (1985) 91:218-24. 2001..0004, FE(CO(2)) = -0.0003, VO(2) = -0.018 l/min). Thus a computerized system, using inspiratory or expiratory configurations, permits extremely precise measurements to be made in a less time-consuming manner than the DB technique...
- A comparison of biologically variable ventilation to recruitment manoeuvres in a porcine model of acute lung injuryDuane J Funk
Department of Anaesthesia, University of Manitoba, Winnipeg, Manitoba, Canada
Respir Res 5:22. 2004....
- The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modellingLisbet Niklason
Department of Clinical Physiology, University Hospital, Getingevagen 4, SE 221 85 Lund, Sweden
Crit Care 12:R53. 2008..The purpose of the present study was to analyze the extent to which shunt contributes to alveolar dead space and perturbs carbon dioxide exchange in ancillary physiological disturbances...
- The effects of anesthesia and muscle paralysis on the respiratory systemGoran Hedenstierna
Clinical Physiology, Department of Medical Sciences, University Hospital, 75185 Uppsala, Sweden
Intensive Care Med 31:1327-35. 2005..Moreover, postoperative lung complications occur in 3-10% after elective abdominal surgery and more in emergency operations...
- Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevanceDan S Karbing
Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 215, DK 9220 Aalborg East, Denmark
Crit Care 11:R118. 2007....
- Pulmonary perfusion in the prone and supine postures in the normal human lungG Kim Prisk
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0931, USA
J Appl Physiol (1985) 103:883-94. 2007Prone posture increases cardiac output and improves pulmonary gas exchange. We hypothesized that, in the supine posture, greater compression of dependent lung limits regional blood flow...
- Recruitment maneuver in pulmonary and extrapulmonary experimental acute lung injuryDouglas R Riva
Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Crit Care Med 36:1900-8. 2008..The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes...
- Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndromeGraciela Martinez-Palli
Servei d Anestesiologia i Reanimacio Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
World J Gastroenterol 11:6858-62. 2005To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome ( HPS ).
- Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipidsPhilipp Markart
Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
Thorax 62:588-94. 2007..Extensive biochemical and biophysical changes of the pulmonary surfactant system occur in the acute respiratory distress syndrome (ARDS)...
- Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndromeJoao B Borges
Respiratory Intensive Care Unit, Pulmonary Department, and General Intensive Care Unit, Emergency Clinics Division, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
Am J Respir Crit Care Med 174:268-78. 2006..The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an efficient maneuver to minimize it...
- Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndromeStefania Redolfi
Respiratory Medicine Unit, University of Brescia, Piazzale Spedali Civili 1, 25100 Brescia, Italy
Respir Med 101:1191-5. 2007..The aim of the study was to investigate the role of leptin in the OHS pathogenesis looking at its relationship to CO(2) sensitivity before and after NIMV in OHS patients...
- Recruitment maneuvers attenuate repeated derecruitment-associated lung injuryWon Jung Koh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Crit Care Med 33:1070-6. 2005..The aim of this study was to assess lung injury associated with repeated derecruitments and to assess whether this type of injury could be attenuated by recruitment maneuvers...
- Relationship between body and leg VO2 during maximal cycle ergometryD R Knight
Department of Medicine, University of California, San Diego, La Jolla 92093 0623
J Appl Physiol (1985) 73:1114-21. 1992..We conclude that the asymptotic behavior of whole body VO2 at maximal WRs is a direct reflection of the VO2 profile at the exercising legs...
- Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndromeL M Malbouisson
, Department of Anesthesiology, , , University of Paris VI, 75013 Paris, France
Am J Respir Crit Care Med 163:1444-50. 2001..76, p = 0.003), suggesting that it may be more accurate than Gattinoni's method...
- Ventilation index and outcome in children with acute respiratory distress syndromeG Paret
Pediatric Intensive Care Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
Pediatr Pulmonol 26:125-8. 1998..We conclude that the VI provides a reliable prognostic marker in children with ARDS, and its increase above 65 indicates a need for orderly intervention with alternative modalities of care...
- Regional distribution of gas and tissue in acute respiratory distress syndrome. I. Consequences for lung morphology. CT Scan ARDS Study GroupL Puybasset
Department of Anesthesiology, Hopital de la Pitie Salpetriere, University of Paris VI and Institut National des Télécommunications, Evry, France
Intensive Care Med 26:857-69. 2000..To compare the computed tomographic (CT) analysis of the distribution of gas and tissue in the lungs of patients with ARDS with that in healthy volunteers...
- High-frequency ventilation for acute lung injury and ARDSJ A Krishnan
Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Chest 118:795-807. 2000..Second, despite the small VTs, high respiratory rates during HFV allow the maintenance of normal or near-normal PaCO2 levels. In this review, the use of HFV as a lung protective strategy for patients with ALI/ARDS is discussed...
- Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injuryScott E Sinclair
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, BB 1253 HSB Box 356522, Seattle, WA 98195 6522, USA
Am J Respir Crit Care Med 166:403-8. 2002..18 x 10(5) versus 2.84 x 10(5) +/- 0.28 x 10(5) nucleated cells/ml; p = 0.021), and injury score (7.0 +/- 3.3 versus 0.7 +/- 0.9; p < 0.0001). We conclude that hypercapnic acidosis is protective against VILI in this model...
- Pressure/volume curves and lung computed tomography in acute respiratory distress syndromeJ J Rouby
Reanimation Chirurgicale Pierre Viars, Dept of Anesthesiology, Hospital Pitié Salpêtrière, University Paris VI, Paris, France
Eur Respir J Suppl 42:27s-36s. 2003..In such patients, alveolar recruitment resulting from positive end-expiratory pressure >10 cmH2O is preceded and accompanied by lung overinflation...
- Effect of air and heliox as carrier gas on CO2 transport in a model of high-frequency oscillation comparing two oscillatorsReinout J Mildner
Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
Crit Care Med 31:1759-63. 2003..To study the effect of carrier gas on CO(2) transport during high-frequency oscillatory ventilation in a closed model...
- Repeated derecruitments accentuate lung injury during mechanical ventilationGee Young Suh
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Korea
Crit Care Med 30:1848-53. 2002..This study was performed to test the hypothesis that derecruitment itself might accentuate lung injury during mechanical ventilation...
- Pulmonary gas exchange response to weaning with pressure-support ventilation in exacerbated chronic obstructive pulmonary disease patientsMiquel Ferrer
Servei de Pneumologia i Al lèrgia Respiratoria, Institut Clinic de Pneumologia i Cirurgia Toracica, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, 08036, Barcelona, Spain
Intensive Care Med 28:1595-9. 2002....
- Recruitment and derecruitment during acute respiratory failure: a clinical studyS Crotti
Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
Am J Respir Crit Care Med 164:131-40. 2001..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
- The automatic lung parameter estimator (ALPE) system: non-invasive estimation of pulmonary gas exchange parameters in 10-15 minutesStephen Edward Rees
Center for Model Based Medical Decision Support, Aalborg University, Denmark
J Clin Monit Comput 17:43-52. 2002Clinical measurements of pulmonary gas exchange abnormalities might help prevent hypoxaemia and be useful in monitoring the effects of therapy. In clinical practice single parameters are often used to describe the abnormality e.g...
- Influence of prone position on gastric mucosal-arterial PCO2 gradientsP Kiefer
Universitat Ulm, Universitätsklinik für Anästhesiologie, Donau, Germany
Intensive Care Med 27:1227-30. 2001..To evaluate the effects of mechanical ventilation in the prone position on gastric mucosal-arterial PCO2 gradients...
Research Grants120 found, 100 shown here
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2006..abstract_text> ..
- STRESS FAILURE AND REMODELING IN PULMONARY CAPILLARIESJohn West; Fiscal Year: 2003..In addition, at the more basic level, this research is devoted to a fundamental bioengineering dilemma of the lung, namely, that the blood-gas barrier has to combine extreme thinness with immense strength. ..
- Integrity of the Pulmonary Blood-Gas BarrierJohn West; Fiscal Year: 2007..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. ..
- Deposition of 0.5 to 2 Micron Aerosol in the Human LungG Prisk; Fiscal Year: 2003..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
- The Effect of Pulmonary Interstitial Edema on Gas ExchangeG Prisk; Fiscal Year: 2007..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
- The Effect of Pulmonary Interstitial Edema on Gas ExchangeG Prisk; Fiscal Year: 2009..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
- NON-G DETERMINANTS OF PULMONARY PERFUSION HETEROGENEITYRobb Glenny; Fiscal Year: 2000..In addition to this new information on basic lung function, pulmonary perfusion distributions can now be explored in small-animal disease models. ..
- Pulmonary Vascular Tree Development, Growth & RemodlingRobb Glenny; Fiscal Year: 2005..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
- Lung Perfusion Heterogeneity and Mechanisms of EdemaSusan Hopkins; Fiscal Year: 2007....
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2007..abstract_text> ..
- Lung Perfusion Heterogeneity and Mechanisms of EdemaSusan R Hopkins; Fiscal Year: 2010..abstract_text> ..
- Effect of Prone Position on Ventilator-Induced Lung InjuryGuido Musch; Fiscal Year: 2010..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..
- REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURYGuido Musch; Fiscal Year: 2007..End of Abstract) ..
- Novel Strategies Targeting Acute Exacerbation of COPDRichard Albert; Fiscal Year: 2007..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
- MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFERDavid Poole; Fiscal Year: 2001....
- HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLSSteven Deem; Fiscal Year: 2002....
- Airway Hyper-responsiveness: from molecule to organMerryn Tawhai; Fiscal Year: 2007..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
- Red Blood Cells, Nitric Oxide and Pulmonary CirculationSteven Deem; Fiscal Year: 2007..and macrovascular levels, and to thereby provide insight into the mechanisms by which RBCs affect pulmonary gas exchange. The knowledge gained from this project will have health-related ramifications, in that it will allow more ..
- Stretch and Vitamin A Effects on Alveolar FormationKURT ALBERTINE; Fiscal Year: 2009..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
- Study of Acid Reflux Therapy for Children with AsthmaWILLIAM TEAGUE; Fiscal Year: 2007..The results of this trial should have a major impact on the understanding and treatment of GER in children with asthma. ..
- Mechanisms of innate immune response modulation by mechanical ventilationWilliam A Altemeier; Fiscal Year: 2010..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
- Pretest Probability Assessment for Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2005..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
- Mitochondrial biogenesis in sepsis-induced organ dysfunctionKAREN E contact WELTY WOLF; Fiscal Year: 2010..These studies will investigate the role of mitochondrial injury and biogenesis in the pathogenesis of organ dysfunction in sepsis, and should lead to new therapies to enhance recovery from organ failures in sepsis. ..
- Dynamics of Vascular Microbubbles and Microdroplets in Gas EmbolotherapyJOSEPH BULL; Fiscal Year: 2007..This approach could potentially be used to treat a variety of cancers and uterine fibroids. ..
- PET Imaging of Local Inflammation and Function in Ventilator Induced Lung InjuryMARCOS VIDAL MELO; Fiscal Year: 2009..abstract_text> ..
- Role of C/EBPalpha in Cytoprotection and Recovery from Lung InjuryMachiko Ikegami; Fiscal Year: 2010..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..
- COPD Clinical Research Network & Clinical Research Skills Core DevelopmentGerard Criner; Fiscal Year: 2007..abstract_text> ..
- PET Imaging of Local Inflammation and Function in Ventilator Induced Lung InjuryMarcos F Vidal Melo; Fiscal Year: 2010..abstract_text> ..
- Sensitive and Specific Molecular Imaging of Pulmonary NodulesBASTIAAN contact DRIEHUYS; Fiscal Year: 2010..The proposed research has relevance to public health because new tools in imaging pulmonary cancers will not only improve patient treatment, but will also accelerate research to develop better therapies. ..
- HORMONAL CONTROL OF LUNG DEVELOPMENT--PTHRP BIOLOGYJohn Torday; Fiscal Year: 1999....
- Regional Hypoxic Pulmonary VasoconstrictionMICHAEL HLASTALA; Fiscal Year: 2006..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. ..
- Exercise for Mental Health: Does Exercise Make People Feel Better?Panteleimon Ekkekakis; Fiscal Year: 2003..The immediate anticipated benefit of this research is the development of physical activity public health recommendations that incorporate affect as a fundamental consideration. ..
- Hormonal Control of Lung Development: PTHrP BiologyJohn Torday; Fiscal Year: 2003..Understanding these mechanisms will enhance knowledge as to how stem cell function in lung injury/repair, and how they may be used effectively to treat lung injury and chronic lung disease in infants. ..
- DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURYRobert Harris; Fiscal Year: 2005..SA3 will compare local measurements of recruitment by PET with the global measures of recruitment by NO uptake kinetics and lung mechanics. ..
- Hormonal Control of Lung Development: PTHrP BiologyJohn Torday; Fiscal Year: 2004..Understanding these mechanisms will enhance knowledge of normal alveolization and response to injury, and may lead to novel treatments for chronic lung disease in infants. ..
- ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASISMachiko Ikegami; Fiscal Year: 2006..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..