pulmonary gas exchange

Summary

Summary: The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.

Top Publications

  1. ncbi Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death
    Anselm K Gitt
    Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
    Circulation 106:3079-84. 2002
  2. ncbi Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchange
    S Kjaergaard
    Aalborg Hospital, Department of Anaesthesiology, Aalborg, Denmark
    Eur J Anaesthesiol 21:296-301. 2004
  3. ncbi Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study
    B Koch
    Medical Faculty of the Ernst Moritz Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23, D 17475 Greifswald, Germany
    Eur Respir J 33:389-97. 2009
  4. ncbi The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases
    R Kessler
    Department of Pulmonology and Sleep Laboratory, University Hospital, Strasbourg, France
    Chest 120:369-76. 2001
  5. ncbi Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosis
    Sven Glaser
    Division of Pulmonary Medicine and Infectious Diseases, University of Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
    Respir Med 103:317-24. 2009
  6. ncbi Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
  7. pmc Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe
    Bastiaan Driehuys
    Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, NC 27710, USA
    Radiology 252:386-93. 2009
  8. ncbi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
  9. ncbi Reproducibility of maximal exercise test data in the HERITAGE family study
    J S Skinner
    Indiana University, Bloomington, USA
    Med Sci Sports Exerc 31:1623-8. 1999
  10. ncbi Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2
    J P Whiteley
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Anaesth 88:771-8. 2002

Detail Information

Publications267 found, 100 shown here

  1. ncbi Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death
    Anselm K Gitt
    Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
    Circulation 106:3079-84. 2002
    ..Thus, we compared these parameters with peak VO2 in identifying patients with CHF at increased risk for death within 6 months after evaluation...
  2. ncbi Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchange
    S Kjaergaard
    Aalborg Hospital, Department of Anaesthesiology, Aalborg, Denmark
    Eur J Anaesthesiol 21:296-301. 2004
    To investigate the clinical application of a mathematical model of pulmonary gas exchange, which ascribes hypoxaemia to shunt and ventilation/perfusion mismatch...
  3. ncbi Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study
    B Koch
    Medical Faculty of the Ernst Moritz Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23, D 17475 Greifswald, Germany
    Eur Respir J 33:389-97. 2009
    ..While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey...
  4. ncbi The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases
    R Kessler
    Department of Pulmonology and Sleep Laboratory, University Hospital, Strasbourg, France
    Chest 120:369-76. 2001
    ..We compare also OHS patients with a group of patients with the association of OSAS and COPD, also known as "overlap" patients...
  5. ncbi Impact of pulmonary hypertension on gas exchange and exercise capacity in patients with pulmonary fibrosis
    Sven Glaser
    Division of Pulmonary Medicine and Infectious Diseases, University of Greifswald, Sauerbruchstrasse, 17475 Greifswald, Germany
    Respir Med 103:317-24. 2009
    ..The further impairment of exercise capacity as well as the extent of dyspnoea in patients with interceding PHT is attributable to a significantly impaired ventilatory inefficiency...
  6. ncbi Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
    ..The current data supports the concept that patchy ventilation is an expression of the integrated system and not just the sum of independent responses of individual airways...
  7. pmc Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe
    Bastiaan Driehuys
    Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, NC 27710, USA
    Radiology 252:386-93. 2009
    ....
  8. ncbi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
    ..In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction...
  9. ncbi Reproducibility of maximal exercise test data in the HERITAGE family study
    J S Skinner
    Indiana University, Bloomington, USA
    Med Sci Sports Exerc 31:1623-8. 1999
    ..The reproducibility of responses to maximal cycle ergometer testing was determined using data from the HERITAGE Family study at four Clinical Centers in the United States and Canada...
  10. ncbi Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2
    J P Whiteley
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Anaesth 88:771-8. 2002
    ..Measures of impairment of oxygenation can be affected by the inspired oxygen fraction...
  11. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  12. ncbi Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
    Peter M Spieth
    Department of Anesthesiology and Intensive Care Therapy, University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Am J Respir Crit Care Med 179:684-93. 2009
    ..Noisy ventilation with variable Vt may improve respiratory function in acute lung injury...
  13. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  14. ncbi Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment
    Jeffrey M Halter
    Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Am J Respir Crit Care Med 167:1620-6. 2003
    ..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
  15. ncbi Probing lung physiology with xenon polarization transfer contrast (XTC)
    K Ruppert
    Department of Radiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Magn Reson Med 44:349-57. 2000
    ..It is further argued that minor pulse-sequence modifications may provide information about the alveolar surface area or lung perfusion...
  16. pmc High-intensity non-invasive positive pressure ventilation for stable hypercapnic COPD
    Wolfram Windisch
    Department of Pneumology, University Hospital Freiburg, Germany
    Int J Med Sci 6:72-6. 2009
    ....
  17. ncbi Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Am J Respir Crit Care Med 165:366-71. 2002
    ..05) compared with conventional ventilation. These data indicate that variable ventilation is effective in improving lung function and gas exchange during acute lung injury...
  18. ncbi Perfluorocarbon species and nebulizer type influence aerosolization rate and particle size of perfluorocarbon aerosol
    Mario Rudiger
    Clinic for Neonatology, Charite Campus Mitte, Berlin, Germany
    J Crit Care 19:42-7. 2004
    ..Aerosolization of perfluorocarbons (PFC) has been proven beneficial in vivo. The present in vitro study was performed to investigate, how PFC-aerosolization is affected by type of nebulizer and PFC properties...
  19. ncbi Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury
    Alysson R Carvalho
    Clinic of Anesthesiology and Intensive Care Therapy, Univ Hospital Dresden, Dresden, Germany
    J Appl Physiol (1985) 110:1083-92. 2011
    ..Random variation of pressure support further redistributes PBF and improves oxygenation compared with conventional PSV...
  20. ncbi Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD
    Pierantonio Laveneziana
    Respiratory Investigation Unit, Department of Medicine, Kingston General Hospital, Queen s University, 102 Stuart Street, Kingston, ON K7L 2V6, Canada
    Eur J Appl Physiol 107:633-43. 2009
    ..cardiodynamic responses and convective oxygen delivery during exercise, resulting in slower ventilatory, pulmonary gas exchange (PGE), and heart rate (HR) kinetics compared with normal...
  21. ncbi Gas exchange modelling: no more gills, please
    C E W Hahn
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, UK
    Br J Anaesth 91:2-15. 2003
  22. ncbi Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome
    Xabier Murgia
    Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Bizkaia, Spain
    Pediatr Res 72:393-9. 2012
    ..Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated...
  23. ncbi Response-time enhancement of a clinical gas analyzer facilitates measurement of breath-by-breath gas exchange
    A D Farmery
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, United Kingdom
    J Appl Physiol (1985) 89:581-9. 2000
    ..With the use of this technique, measurements required for non-steady-state and tidal gas-exchange models can be made easily and reliably in the clinical setting...
  24. ncbi Preoperative gender differences in pulmonary gas exchange in morbidly obese subjects
    Gerald S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, 6420 Clayton Road, Suite 290, Saint Louis, MO 63117, USA
    Obes Surg 18:1587-98. 2008
    Morbidly obese men may have poorer pulmonary gas exchange compared to morbidly obese women (see Zavorsky et al., Chest 131:362-367, 2007)...
  25. ncbi Hyperpolarized 3He MR lung ventilation imaging in asthmatics: preliminary findings
    T A Altes
    Department of Radiology, University of Virginia, Charlottesville, Virginia, USA
    J Magn Reson Imaging 13:378-84. 2001
    ..Hyperpolarized 3He lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy...
  26. ncbi Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model
    Carissa L Bellardine
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 34:439-45. 2006
    ..We aimed at testing VV in a large animal lung injury model and exploring the mechanism of improvement in gas exchange seen with VV...
  27. ncbi Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension
    B Rosengarten
    Department of Neurology, University Hospital, Justus Liebig University Giessen, Giessen, Germany
    Cerebrovasc Dis 21:194-200. 2006
    ..We investigated the impact of these agents on cerebral microcirculatory regulation in patients suffering from this disease...
  28. ncbi Exercise pathophysiology in patients with primary pulmonary hypertension
    X G Sun
    Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
    Circulation 104:429-35. 2001
    ..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
  29. ncbi Cardiac reserve and pulmonary gas exchange kinetics in patients with stroke
    Corey R Tomczak
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton AB, Canada
    Stroke 39:3102-6. 2008
    ..We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects.
  30. ncbi Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans
    Andrew T Lovering
    Department of Human Physiology, 1240 University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol (1985) 104:1418-25. 2008
    ..were made into a peripheral vein at rest and during exercise and recovery (3-5 min postexercise) with pulmonary gas exchange measured simultaneously...
  31. ncbi Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy
    Abdulaziz Boker
    Department of Anesthesia and Critical Care, Abdulaziz University, Jeddah, Saudi Arabia
    Anesthesiology 100:608-16. 2004
    ..VV was compared with CV in patients undergoing abdominal aortic aneurysmectomy, a patient group known to be at risk of deteriorating lung function perioperatively...
  32. ncbi Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002
    ..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
  33. ncbi Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis
    H Olschewski
    Depatment of Internal Medicine II, Justus Liebig University, Giessen, Germany
    Am J Respir Crit Care Med 160:600-7. 1999
    ..Long-term therapy with inhaled iloprost may be life saving in decompensated right heart failure from pulmonary hypertension secondary to lung fibrosis...
  34. ncbi Acute asthma in adults: a review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 125:1081-102. 2004
    ..This review describes the epidemiology, costs, pathophysiology, mortality, and management of adult AA in the ED and in the ICU...
  35. ncbi Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
    ..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
  36. ncbi Influence of age, sex, body size, smoking, and beta blockade on key gas exchange exercise parameters in an adult population
    Sven Glaser
    Medical Faculty of the Ernst Moritz Arndt University, Department of Internal Medicine B Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Street 23, D 17475 Greifswald, Germany
    Eur J Cardiovasc Prev Rehabil 17:469-76. 2010
    ..This study planned to consider the impact of these factors on CPET values and develop reference equations on the basis of a large-scale population-based survey...
  37. ncbi Additives in intravenous anesthesia modulate pulmonary inflammation in a model of LPS-induced respiratory distress
    J J Haitsma
    Departments of Anesthesiology, Surgery and Neurosurgery, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA
    Acta Anaesthesiol Scand 53:176-82. 2009
    ..In the present study, we hypothesized that pulmonary inflammation could be modulated by propofol with EDTA compared with propofol with sulfite...
  38. ncbi Prevention of atelectasis formation during induction of general anesthesia
    Marco Rusca
    Departments of Anesthesiology, University Hospital, Lausanne, Switzerland
    Anesth Analg 97:1835-9. 2003
    ..005). Atelectasis formation is prevented by application of PEEP during the anesthesia induction despite the use of large oxygen concentrations, resulting in improved oxygenation...
  39. ncbi Design of a new variable-ventilation method optimized for lung recruitment in mice
    Apiradee Thammanomai
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 104:1329-40. 2008
    ..In addition, variable stretch patterns delivered to the lung by VV can reduce the progression of lung injury due to ventilation in injured mice...
  40. ncbi Quantitative measurement of regional lung ventilation using 3He MRI
    Anselm J Deninger
    Amersham Health R and D, Medeon, SE 205 12 Malmö, Sweden
    Magn Reson Med 48:223-32. 2002
    ..The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values...
  41. ncbi Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome
    Elena Gastiasoro-Cuesta
    Department of Pediatrics, Hospital de Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
    Pediatrics 117:295-303. 2006
    ..To date, lucinactant has not been compared with an animal-derived surfactant in a premature animal model...
  42. ncbi High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
  43. ncbi Effects of four intraoperative ventilatory strategies on respiratory compliance and gas exchange during laparoscopic gastric banding in obese patients
    W A Almarakbi
    Department of Anesthesia, Ain Shams University, Cairo, Egypt
    Br J Anaesth 102:862-8. 2009
    ..This study was performed to determine whether repeated lung recruitment combined with PEEP improves respiratory compliance and arterial partial pressure of oxygen (Pa(O2)) in obese patients undergoing laparoscopic gastric banding...
  44. ncbi Influence of exogenous fat emulsion on pulmonary gas exchange after major surgery
    Souji Sane
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    World J Surg 26:297-302. 2002
    ..The aim of this study was to evaluate the influence of exogenous fat emulsion on pulmonary gas exchange in the early period after major surgery...
  45. ncbi Video-assisted thoracoscopic surgery does not deteriorate postoperative pulmonary gas exchange in spontaneous pneumothorax patients
    Y Sekine
    Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan
    Eur J Cardiothorac Surg 16:48-53. 1999
    Video-assisted thoracoscopic surgery (VATS) is generally recognized as a less invasive method than thoracotomy. However, the influence of VATS on postoperative pulmonary gas exchange has yet to be evaluated.
  46. ncbi Comparison between the Datex-Ohmeda M-COVX metabolic monitor and the Deltatrac II in mechanically ventilated patients
    S McLellan
    Department of Anaesthetics, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, Scotland, UK
    Intensive Care Med 28:870-6. 2002
    ..To compare the M-COVX and the Deltatrac II metabolic monitors under clinical conditions...
  47. ncbi Determinants of oxygen uptake. Implications for exercise testing
    D C Poole
    Department of Kinesiology, Kansas State University, Manhattan, USA
    Sports Med 24:308-20. 1997
    ....
  48. ncbi Validity and reliability of selected commercially available metabolic analyzer systems
    L D Hodges
    Research Centre for Health Studies, Buckinghamshire Chilterns University College, Buckinghamshire, UK
    Scand J Med Sci Sports 15:271-9. 2005
    ..This presents a significant practical challenge in light of the speed with which technical developments in the field occur and we make some suggestions for the formulation of intersystem comparison studies...
  49. ncbi Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury
    A Katz
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 164:260-4. 2001
    ..Although heliox improved gas exchange during HFOV in our model, increased tidal volume delivery may limit clinical applicability...
  50. ncbi Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans
    Bruno Grassi
    Dipartimento di Scienze e Tecnologie Biomediche, School of Medicine, University of Milan, Milan, Italy
    J Appl Physiol (1985) 95:149-58. 2003
    ..The lack of a drop in muscle oxygenation at the transition suggests adequacy of O2 availability in relation to needs...
  51. ncbi Ventilation-perfusion distributions in different porcine lung injury models
    P Neumann
    Department of Clinical Physiology, University of Uppsala, Sweden
    Acta Anaesthesiol Scand 45:78-86. 2001
    ..Although V(A)/Q distributions can be related to pathogenic aspects of the three study groups, we did not observe specific V(A)/Q patterns which allow diagnosis of the type of lung injury from a recovered V(A)/Q distribution...
  52. ncbi Non-invasive mechanical ventilation in status asthmaticus
    M M Fernandez
    Intensive Care Department, Corporació Sanitària Parc Taulí s n, 08208 Sabadell, Spain
    Intensive Care Med 27:486-92. 2001
    ..To evaluate our clinical experience with the use of non-invasive mechanical ventilation (NIMV) in patients with an acute asthmatic attack...
  53. ncbi Is hemoglobin desaturation related to blood viscosity in athletes during exercise?
    P Connes
    UPRES EA 2991 Sport, Performance et Santé, Montpellier, France
    Int J Sports Med 25:569-74. 2004
    ..Whether this could impair the blood gas barrier and result in exercise-induced hypoxemia requires further study...
  54. ncbi Improved arterial oxygenation with biologically variable or fractal ventilation using low tidal volumes in a porcine model of acute respiratory distress syndrome
    Abdulaziz Boker
    Department of Anesthesiology, University of Manitoba, Winnipeg, Canada
    Am J Respir Crit Care Med 165:456-62. 2002
    ..With V (bv), VT variability demonstrated an inverse power law indicating fractal behavior. In this model of ARDS, V (bv) improved Pa(O(2)) at lower peak airway pressure and IL-8 levels compared with V (c)...
  55. ncbi Determining the best ventilatory efficiency measure to predict mortality in patients with heart failure
    Robert L Bard
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48106, USA
    J Heart Lung Transplant 25:589-95. 2006
    ..Therefore, we investigated the relative prognostic power of different measures of ventilatory efficiency calculated from maximal and sub-maximal exercise in patients with heart failure...
  56. ncbi Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines
    Eric K Chu
    Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care Med 32:168-74. 2004
    ..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
  57. ncbi Spatial and functional relationships between air conduits and blood capillaries in the pulmonary gas exchange tissue of adult and developing chickens
    Andrew N Makanya
    Institute of Anatomy, Department of Medicine, University of Fribourg, Rte Albert Gockel 1, CH 1700, Fribourg, Switzerland
    Microsc Res Tech 74:159-69. 2011
    ..Our findings clarify the mode of gas exchange in the parabronchial mantle and illuminate the basis for the functional efficiency of the avian lung...
  58. ncbi Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanders
    Peter D Wagner
    Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Appl Physiol (1985) 92:1393-400. 2002
    b>Pulmonary gas exchange and acid-base state were compared in nine Danish lowlanders (L) acclimatized to 5,260 m for 9 wk and seven native Bolivian residents (N) of La Paz (altitude 3,600-4,100 m) brought acutely to this altitude...
  59. ncbi Differences in ventilatory inefficiency between pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
    Zhenguo Zhai
    Imperial College School of Medicine, Imperial College London, London, England
    Chest 140:1284-91. 2011
    ..Little is known about whether these measures can be applied to all forms of PH, in particular chronic thromboembolic pulmonary hypertension (CTEPH), wherein thrombotic vascular occlusion has an impact on gas exchange...
  60. ncbi Ramp exercise protocols for clinical and cardiopulmonary exercise testing
    J Myers
    Cardiology Division, Palo Alto VA Health Care System, California 94304, USA
    Sports Med 30:23-9. 2000
    ..This article reviews these issues and discusses the evolution of ramp testing which has occurred in the 1990s...
  61. pmc Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans
    Richard B Weiskopf
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, Box 0648, San Francisco, CA 94143 0648, USA
    Anesth Analg 114:511-9. 2012
    ..We tested the hypothesis that transfusion can cause mild pulmonary dysfunction that has not been noticed clinically and is not sufficiently severe to fit the definition of transfusion-related acute lung injury...
  62. ncbi Topographic basis of bimodal ventilation-perfusion distributions during bronchoconstriction in sheep
    Marcos F Vidal Melo
    Cardiac Anesthesia Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 171:714-21. 2005
    ..Assessment of the subresolution VA/Q heterogeneity is therefore essential to accurately quantify global gas exchange impairment during bronchoconstriction...
  63. ncbi Performance characteristics of gas analysis systems: what we know and what we need to know
    G Atkinson
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK
    Int J Sports Med 26:S2-10. 2005
    ..We stressed that this judgement should be based on expert-agreed position statements about acceptable error, which unfortunately have yet to be formulated for gas analysis systems...
  64. pmc A mathematical model of pulmonary gas exchange under inflammatory stress
    Angela Reynolds
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 264:161-73. 2010
    ....
  65. ncbi A methodology to assess the accuracy of a portable metabolic system (VmaxST)
    Fabrice Prieur
    Laboratoire d Analyse Multidisciplinaire des Pratiques Sportives, UFR STAPS de Liévin, Université d Artois, Lievin, France
    Med Sci Sports Exerc 35:879-85. 2003
    ..Validity of a portable metabolic system (VmaxST) was investigated during gas exchanges simulations by a mechanical system (GESS) and during human exercise...
  66. ncbi Effects of spontaneous breathing during airway pressure release ventilation on intestinal blood flow in experimental lung injury
    Rudolf Hering
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Anesthesiology 99:1137-44. 2003
    ..The authors hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and intestinal blood flow than APRV without SB...
  67. pmc The prone position results in smaller ventilation defects during bronchoconstriction in asthma
    R Scott Harris
    Department of Medicine, Pulmonary and Critical Care Unit, Bulfinch 148, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol (1985) 107:266-74. 2009
    ..In asthma, the size and location of ventilation defects is affected by body position and likely affected by small differences in lung expansion during bronchoconstriction...
  68. ncbi Non-invasive estimation of shunt and ventilation-perfusion mismatch
    Søren Kjaergaard
    Department of Anaesthesiology, Aalborg Hospital, Aarhus University Hospitals, 9000 Aalborg, Denmark
    Intensive Care Med 29:727-34. 2003
    To investigate whether parameters describing pulmonary gas exchange (shunt and ventilation-perfusion mismatch) can be estimated consistently by the use of non-invasive data as input to a mathematical model of oxygen transport.
  69. ncbi Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humans
    Nicholas D Giardino
    Department of Rehabilitation Medicine, University of Washington, 1959 SE Pacific Street, Seattle, WA 98195, USA
    Am J Physiol Heart Circ Physiol 284:H1585-91. 2003
    Respiratory sinus arrhythmia (RSA) may be associated with improved efficiency of pulmonary gas exchange by matching ventilation to perfusion within each respiratory cycle. Respiration rate, tidal volume, minute ventilation (...
  70. ncbi Exercise-induced intrapulmonary arteriovenous shunting and pulmonary gas exchange
    Michael K Stickland
    The John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1532, USA
    Exerc Sport Sci Rev 34:99-106. 2006
    ..intrapulmonary shunt vessels during exercise, which may contribute to the exercise-induced impairment in pulmonary gas exchange. These findings are consistent with substantial anatomical data demonstrating large-diameter (> 25 ..
  71. ncbi Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humans
    Shoji Ito
    Department of Anaesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
    Exp Physiol 91:935-41. 2006
    ..arrhythmia (RSA) and anatomical dead space volume, respectively, contribute to improve the efficiency of pulmonary gas exchange in humans. We examined the effect of blocking vagal nerve activity with atropine on pulmonary gas exchange...
  72. ncbi Comparison of effects of perflubron and surfactant lung lavage on pulmonary gas exchange in a piglet model of meconium aspiration
    Rolf L Schlosser
    Department of Pediatrics, Johann Wolfgang Goethe University Hospital, Frankfurt Main, Germany
    Biol Neonate 81:126-31. 2002
    ..Lavage with exogenous surfactant as well as with PFOB improve pulmonary gas exchange in a piglet model of meconium aspiration.
  73. ncbi Cardiopulmonary response to exercise in patients with liver cirrhosis and impaired pulmonary gas exchange
    Malcolm Lemyze
    Department of Respiratory and Critical Care Medicine, Schaffner Hospital, 99 route de La Bassée, Lens, France
    Respir Med 105:1550-6. 2011
    Maximal exercise capacity and pulmonary gas exchange are both commonly impaired in liver cirrhosis...
  74. ncbi Pressure support compared with controlled mechanical ventilation in experimental lung injury
    Rolf Dembinski
    Department of Anesthesiology, Universitaetsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Anesth Analg 94:1570-6, table of contents. 2002
    ..005). We conclude that, in this model of ALI, PSV improves gas exchange because of a reduction of .V(A)/.Q inequality. However, improvements in .V(A)/.Q distribution may be more effective with CMV than with PSV...
  75. ncbi Flow-through respirometry applied to chamber systems: pros and cons, hints and tips
    J R B Lighton
    Department of Biology, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154 4004, USA
    Comp Biochem Physiol A Mol Integr Physiol 158:265-75. 2011
    ....
  76. ncbi Pulmonary gas exchange is reduced by the cardiovascular diving response in resting humans
    Johan P A Andersson
    Department of Cell and Organism Biology, Lund University, Lund, Sweden
    Respir Physiol Neurobiol 160:320-4. 2008
    ..4 ml min(-1)kg(-1)). We conclude that the cardiovascular adjustments of the diving response reduces pulmonary gas exchange in resting humans, allowing longer apneas by preserving the lungs' O(2) store for use by vital organs.
  77. ncbi Relation between PaO2/FIO2 ratio and FIO2: a mathematical description
    Jerome Aboab
    Réanimation Médicale, AP HP, Hopital Henri Mondor, 51, av du Maréchal de Lattre de Tassigny, 94010 Creteil, France
    Intensive Care Med 32:1494-7. 2006
  78. ncbi Minimal model quantification of pulmonary gas exchange in intensive care patients
    Dan S Karbing
    Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 204, DK 9220 Aalborg East, Denmark
    Med Eng Phys 33:240-8. 2011
    Mathematical models are required to describe pulmonary gas exchange. The challenge remains to find models which are complex enough to describe physiology and simple enough for clinical practice...
  79. pmc Clinical review: Extracorporeal membrane oxygenation
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Crit Care 15:243. 2011
    ..The current enthusiasm for ECMO in its various aspects should not, however, obscure the consideration of the potential complications associated with this life-saving technique, primarily brain hemorrhage...
  80. pmc Validity, reliability and stability of the portable Cortex Metamax 3B gas analysis system
    D J MacFarlane
    Institute of Human Performance, The University of Hong Kong, Pokfulam, Hong Kong
    Eur J Appl Physiol 112:2539-47. 2012
    ..It is concluded the MM3B produces acceptably stable and reliable results, but is not adequately valid during moderate and vigorous exercise without some further correction of VO(2) and VCO(2)...
  81. ncbi An experimental rat model of ex vivo lung perfusion for the assessment of lungs after prostacyclin administration: inhaled versus parenteral routes
    Paulo Francisco Guerreiro Cardoso
    Department of Cardiorespiratory Diseases, Thoracic Surgery Section, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    J Bras Pneumol 37:589-97. 2011
    ..To present a model of prostaglandin I2 (PGI2) administration (inhaled vs. parenteral) and to assess the functional performance of the lungs in an ex vivo lung perfusion system...
  82. pmc Hyperpolarized Xe MR imaging of alveolar gas uptake in humans
    Zackary I Cleveland
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e12192. 2010
    ..However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange...
  83. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
    The literature on pulmonary gas exchange at rest, during exercise, and with weight loss in the morbidly obese (body mass index or BMI > or = 40 kg m(-2)) is reviewed...
  84. ncbi Pulmonary gas exchange during exercise in pigs
    S R Hopkins
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623
    J Appl Physiol (1985) 86:93-100. 1999
    ..These data suggest that the pig animal model is well suited for studying the mechanism of exercise-induced VA/Q inequality...
  85. ncbi Thin-section CT abnormalities and pulmonary gas exchange impairment in workers exposed to asbestos
    Andrea Sette
    Pulmonary Function and Clinical Exercise Physiology Unit, Div of Respiratory Diseases, Federal Univ of São Paulo, Rua Professor Francisco de Castro 54, Vila Clementino, CEP 04020 050 São Paulo, Brazil
    Radiology 232:66-74. 2004
    To evaluate the relationship between abnormalities at thin-section computed tomography (CT) and indexes of pulmonary gas exchange impairment at rest and during moderate exercise in workers exposed to asbestos.
  86. ncbi Teaching pulmonary gas exchange physiology using computer modeling
    Kent S Kapitan
    Division of Pulmonary Medicine, School of Medicine, Southern Illinois University, Springfield, Illinois 62794 9636, USA
    Adv Physiol Educ 32:61-4. 2008
    ..To overcome this difficulty, I have developed an interactive computer simulation of pulmonary gas exchange that is web based and allows the student to vary multiple factors simultaneously and observe the final ..
  87. ncbi Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchange
    D Torbati
    Division Critical Care Medicine, Miami Children s Hospital, FL 33155 3009, USA
    Crit Care Med 27:1878-84. 1999
    ..To compare normative ventilatory and gas-exchange data and anesthetic requirements in male and female rats subjected to critical care conditions...
  88. pmc Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung
    G Kim Prisk
    Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
    J Appl Physiol (1985) 108:53-9. 2010
    ..We hypothesized that infusion would disrupt pulmonary gas exchange by increasing ventilation/perfusion ((.)VA/(...
  89. ncbi Understanding pulmonary gas exchange: ventilation-perfusion relationships
    John B West
    Am J Physiol Lung Cell Mol Physiol 287:L1071-2. 2004
    ..Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949 (http://ajplegacy.physiology.org/cgi/reprint/158/1/21)). Riley RL...
  90. ncbi Oxygen in air (FiO2 0.4) improves gas exchange in young healthy patients during general anesthesia
    Anil Agarwal
    Department of Anesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Can J Anaesth 49:1040-3. 2002
    ..higher the O(2) concentration the faster is the development of atelectasis, an important cause of impaired pulmonary gas exchange during general anesthesia (GA). We evaluated the effect of ventilation with 0.4 FiO(2) in air, 0...
  91. ncbi Interactions between heart rate variability and pulmonary gas exchange efficiency in humans
    Peter Y W Sin
    Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
    Exp Physiol 95:788-97. 2010
    ..component of heart rate variability (respiratory sinus arrhythmia, RSA) has been associated with improved pulmonary gas exchange efficiency in humans via the apparent clustering and scattering of heart beats in time with the ..
  92. ncbi Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture
    F Staffieri
    Section of Critical Care and Anesthesia, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
    Equine Vet J 41:747-52. 2009
    ..It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange...
  93. ncbi Validity and reliability of three commercially available breath-by-breath respiratory systems
    James Carter
    Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Eur J Appl Physiol 86:435-41. 2002
    ..8-45.8%). The exercise study showed the Oxycon Pro and Oxycon Alpha to be both valid and reliable on-line systems for the measurement of parameters of respiration, at least at workloads up to 150 W...
  94. ncbi Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation
    Y Imai
    Pathophysiology Research Laboratory, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8509, Japan
    J Appl Physiol 91:1836-44. 2001
    ..Conventional mechanical ventilation using lung protection strategies (low V(T) high PEEP) only attenuated the decrease in oxygenation and pulmonary compliance. Therefore, HFOV may be a preferable option as a lung protection strategy...
  95. ncbi Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension
    Isabel Blanco
    Department of Pulmonary Medicine, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona
    Am J Respir Crit Care Med 181:270-8. 2010
    ..However, vasodilators may inhibit hypoxic pulmonary vasoconstriction and impair gas exchange in this condition...
  96. ncbi Systematic review of noninvasive positive pressure ventilation in severe stable COPD
    M A Kolodziej
    Dept of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospitals, University of Alberta, Edmonton, AB, Canada
    Eur Respir J 30:293-306. 2007
    ....
  97. ncbi Prone positioning improves oxygenation in post-traumatic lung injury--a prospective randomized trial
    Gregor Voggenreiter
    Department of Trauma Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
    J Trauma 59:333-41; discussion 341-3. 2005
    ..In a prospective randomized trial the effect of prone positioning on the duration of mechanical ventilation was evaluated in multiple trauma patients and was compared with patients ventilated in supine position...
  98. ncbi Intercomparison of recruitment maneuver efficacy in three models of acute lung injury
    Sung Chul Lim
    Department of Pulmonary Critical Care Medicine, Regions Hospital, University of Minnesota, St Paul, MN, USA
    Crit Care Med 32:2371-7. 2004
    ..To compare the relative efficacy of three forms of recruitment maneuvers in diverse models of acute lung injury characterized by differing pathoanatomy...
  99. ncbi Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome
    Anne Hilgendorff
    Department of Pediatrics and Neonatology, Justus Liebig University Giessen, Germany
    Crit Care Med 34:203-10. 2006
    ..remains a relevant cause of neonatal respiratory failure and is characterized by severe impairment of pulmonary gas exchange, surfactant inactivation, and pronounced inflammatory changes...
  100. pmc Bench-to-bedside review: Recruitment and recruiting maneuvers
    Stephen E Lapinsky
    Intensive Care Unit, Mount Sinai Hospital, and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Crit Care 9:60-5. 2005
    ..In this review we discuss the pathophysiologic basis for the use of recruitment maneuvers and recent evidence, as well as the practical application of the technique...
  101. pmc Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis
    Richard Kraemer
    Department of Paediatrics, University of Berne, Inselspital CH 3010 Berne, Switzerland
    Respir Res 7:138. 2006
    ....

Research Grants65

  1. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  2. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  3. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  4. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  5. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  6. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  7. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  8. Novel Strategies Targeting Acute Exacerbation of COPD
    Richard Albert; Fiscal Year: 2007
    ..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
  9. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  10. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..and macrovascular levels, and to thereby provide insight into the mechanisms by which RBCs affect pulmonary gas exchange. The knowledge gained from this project will have health-related ramifications, in that it will allow more ..
  11. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....
  12. Exercise for Mental Health: Does Exercise Make People Feel Better?
    Panteleimon Ekkekakis; Fiscal Year: 2003
    ..The immediate anticipated benefit of this research is the development of physical activity public health recommendations that incorporate affect as a fundamental consideration. ..
  13. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
  14. Molecular imaging using hyperpolarized carbon-13
    Stephen Kadlecek; Fiscal Year: 2007
    ..Key Words: Polarized Carbon-13 MRI; Metabolic imaging; Molecular imaging. [unreadable] [unreadable] [unreadable]..
  15. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2009
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  16. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
  17. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2008
    ..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
  18. Immunomodulatory Effects of Mechanical Ventilation
    WILLIAM ALTEMEIER; Fiscal Year: 2007
    ....
  19. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  20. Stretch and Vitamin A Effects on Alveolar Formation
    KURT ALBERTINE; Fiscal Year: 2009
    ..We will test the hypothesis that the promoter regions of our 3 target genes are retinoid responsive. Thus, this project will provide novel mechanistic insights about alveolar formation and its dysregulation in CLD. ..
  21. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  22. Neural Mechanisms in Congestive Heart Failure
    GLENN TONEY; Fiscal Year: 2007
    ..This information will yeild new and potentially important insight into the processes that lead to sympathetic activation and progression of disease severity in CHF. ..
  23. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2007
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  24. Arterial Stiffness & Age-Effects on Circulatory Control
    J Taylor; Fiscal Year: 2007
    ..We seek renewed funding to examine fully sympatho-vagal interactions with age and disease and prospectively assess the effects of exercise. ..
  25. Integrative Models of Neural Adaptive Control
    Chi Sang Poon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  26. Physical Activity Assessment Using Variability in Accelerometer Counts
    David Bassett; Fiscal Year: 2007
    ..The improved method could then be used in future studies of the relationships between physical activity and health outcomes. [unreadable] [unreadable] [unreadable]..
  27. Physical Work Capacity After Traumatic Brain Injury
    KURT MOSSBERG; Fiscal Year: 2009
    ..The latter is of particular importance from a public health perspective since the individual with TBI is usually young and will endure the permanent disabling effects of TBI for many years. ..
  28. Micromechanics of the airway smooth muscle cell
    Jeffrey Fredberg; Fiscal Year: 2009
    ..Dalhousie, addressing imaging systems and CSK remodeling;Daniel Navajas, Lead Investigator, U. Barcelona, addressing cell stretch. ..
  29. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    CAROLE MARCUS; Fiscal Year: 2008
    ..These studies will help elucidate the pathophysiology of OSAS in obese adolescents, ultimately resulting in improved management of this disease. ..
  30. Contributions of sleep/rhythms/fatigue to "chemobrain"
    Sonia Ancoli Israel; Fiscal Year: 2009
    ..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..
  31. Sympathetic Nervous System & Metabolism in Older Humans
    Christopher Bell; Fiscal Year: 2008
    ..abstract_text> ..
  32. TGF BETA RECEPTOR DYNAMICS
    Edward Leof; Fiscal Year: 2008
    ..Answers to these questions are critical if the processes mediating the various cellular phenotypes induced by TGF-beta are to be elucidated. ..
  33. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  34. C-Reactive Protein in Extremely Low Birth Weight Neonates
    Namasivayam Ambalavanan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. Exhaled Nitric Oxide: Mechanisms and Limitations
    STEVEN CARL GEORGE; Fiscal Year: 2010
    ..Understanding the source of exhaled nitric oxide may significantly impact the clinical management of the disease. ..
  37. PLEURAL LIQUID EXCHANGE AND LUNG MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2007
    ..A specific objective is to develop a method to separate passive from active transport properties of pericardium and diaphragm, tissues that have both mesothelium and interstitium. ..
  38. Nonesterified Fatty Acids and Cardiovascular Aging
    J Taylor; Fiscal Year: 2006
    ..This work is clinically relevant because these associations may provide insight into the etiology of the increased incidence of cardiovascular disease with age. ..
  39. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  40. Respiratory activities of intrinsic tongue muscles
    E Bailey; Fiscal Year: 2004
    ....
  41. PULMONARY INTERSTITIAL MECHANICS
    STEPHEN LAI FOOK; Fiscal Year: 2004
    ..lungs. These studies will measure steric exclusion of albumin in interstitial cuffs of vessels ranging from arterioles to large vessels. ..
  42. REGULATION OF NUTRIENT METABOLISM IN MALES AND FEMALES
    TRACY HORTON; Fiscal Year: 2004
    ..These studies will further our understanding of the metabolic basis for disease in males and females and begin to identify gender specific effects of interventions. ..
  43. VOLTAGE-GATED PROTON CHANNELS IN ALVEOLAR EPITHELIUM
    THOMAS DECOURSEY; Fiscal Year: 2003
    ..Demonstration that H+ current fluctuations result from stochastic gating of H+ channels will provide strong evidence that the molecule is an ion channel rather than a carrier. ..
  44. Role of Estrogen in Exercise-Induced VEGF Expression
    Pauline Entin; Fiscal Year: 2003
    ..The results of this study will contribute to the assessment of the risk/benefit ratio for hormone replacement therapy, particularly in the context of those at risk for cardiovascular disease. ..
  45. OPTIMIZED 3D SPIN-ECHO MR IMAGING OF THE CNS
    John Mugler; Fiscal Year: 2002
    ....
  46. SLEEP AND ENTERTAIMENT OF SCN FUNCTION
    Kingman Strohl; Fiscal Year: 2002
    ..abstract_text> ..
  47. SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERS
    Kingman Strohl; Fiscal Year: 2002
    ..We will disseminate of educational assessments, patient-oriented material, and clinical pathways through local and national consultants in both the public and private sector, as well as through interaction with other awardees. ..
  48. INSULIN SENSITIVITY IN NON-OBESE SUBJECTS
    Bakary Sonko; Fiscal Year: 2002
    ..S. population. The investigator does not have a major grant and the awarding of this grant will help him to generate the necessary data to allow him to apply for such a grant. This will be a significant burst to his career development. ..
  49. SYNAPTIC MECHANISMS IN RESPIRATORY CONTROL
    Chi Sang Poon; Fiscal Year: 2002
    ..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
  50. GENDER AND MENOPAUSE ON NUTRIENT AND ENERGY METABOLISM
    TRACY HORTON; Fiscal Year: 2001
    ..These studies will further our understanding of the metabolic basis for disease risk in males and females. ..
  51. REGULATION OF PULMONARY ENDOTHELIAL PERMEABILITY
    Mary Townsley; Fiscal Year: 2002
    ..Fura PE3, a ratiometric dye, will be used to measure Ca2+ transients, while patch clamp techniques will allow direct measurement of store operated Ca2+ channel activity. ..
  52. BioMediator: Biologic Data Integration& Analysis System
    Peter Tarczy Hornoch; Fiscal Year: 2005
    ..abstract_text> ..
  53. Xth Oxford Conference on Modeling and Control of Breathing
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  55. Discovery of biomarkers of pulmonary hypertension
    Rubin Tuder; Fiscal Year: 2005
    ..abstract_text> ..
  56. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  57. Ventilator-Induced Lung Injury:Mechanisms & Consequences
    Scott Sinclair; Fiscal Year: 2005
    ..Aim 3A: Document cyclical airway collapse and reopening via changes in regional ventilation distribution. Aim 3B: Validate a method to estimate appropriate PEEP level to prevent cyclical airway collapse. ..
  58. Development of a Novel Gas Embolotherapy Technique
    JOSEPH BULL; Fiscal Year: 2005
    ..The proposed research is an essential first step in developing this potentially revolutionary technique. ..
  59. Lungs Pathology Detection Using Hyperpolarized 129Xe
    Kai Ruppert; Fiscal Year: 2006
    ..Finally, the performance of the optimized NMR pulse sequence techniques will be evaluated by detecting and monitoring the development of emphysema in a rabbit model. [unreadable] [unreadable]..
  60. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  61. COPD Clinical Research Network & Clinical Research Skills Core Development
    Gerard Criner; Fiscal Year: 2007
    ..abstract_text> ..
  62. DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURY
    Robert Harris; Fiscal Year: 2005
    ..SA3 will compare local measurements of recruitment by PET with the global measures of recruitment by NO uptake kinetics and lung mechanics. ..
  63. HORMONAL REGULATION OF LUNG DEVELOPMENT; PTHrP BIOLOGY
    John Torday; Fiscal Year: 2009
    ..These studies will provide important insights to the pathophysiology and treatment of chronic lung diseases of the newborn and adult alike. ..