pulmonary gas exchange

Summary

Summary: The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.

Top Publications

  1. ncbi The pulmonary physician in critical care. 8: Ventilatory management of ALI/ARDS
    J J Cordingley
    Department of Anaesthesia and Intensive Care, Royal Brompton Hospital, London SW3 6NP, UK
    Thorax 57:729-34. 2002
  2. ncbi The fall in exhaled nitric oxide with ventilation at low lung volumes in rabbits: an index of small airway injury
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Universita degli Studi di Milano, 20133 Milan, Italy
    Respir Physiol Neurobiol 160:215-23. 2008
  3. ncbi Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension
    Isabel Blanco
    Department of Pulmonary Medicine, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona
    Am J Respir Crit Care Med 181:270-8. 2010
  4. ncbi Cardiac reserve and pulmonary gas exchange kinetics in patients with stroke
    Corey R Tomczak
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton AB, Canada
    Stroke 39:3102-6. 2008
  5. ncbi Exercise pathophysiology in patients with primary pulmonary hypertension
    X G Sun
    Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
    Circulation 104:429-35. 2001
  6. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
  7. ncbi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
  8. ncbi Influence of exogenous fat emulsion on pulmonary gas exchange after major surgery
    Souji Sane
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    World J Surg 26:297-302. 2002
  9. ncbi Sigh in supine and prone position during acute respiratory distress syndrome
    Paolo Pelosi
    Dipartimento di Scienze Cliniche e Biologiche, , Ospedale di Circolo, Fondazione Macchi, Varese
    Am J Respir Crit Care Med 167:521-7. 2003
  10. ncbi Understanding pulmonary gas exchange: ventilation-perfusion relationships
    John B West
    Am J Physiol Lung Cell Mol Physiol 287:L1071-2. 2004

Research Grants

  1. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2006
  2. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
  3. STRESS FAILURE AND REMODELING IN PULMONARY CAPILLARIES
    John West; Fiscal Year: 2003
  4. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2007
  5. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
  6. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
  7. NON-G DETERMINANTS OF PULMONARY PERFUSION HETEROGENEITY
    Robb Glenny; Fiscal Year: 2000
  8. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2007
  9. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
  10. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2007

Detail Information

Publications194 found, 100 shown here

  1. ncbi The pulmonary physician in critical care. 8: Ventilatory management of ALI/ARDS
    J J Cordingley
    Department of Anaesthesia and Intensive Care, Royal Brompton Hospital, London SW3 6NP, UK
    Thorax 57:729-34. 2002
    ..Current data relating to ventilation in ARDS are reviewed. Recent studies suggest that reduced mortality may be achieved by using a strategy which aims at preventing overdistension of lungs...
  2. ncbi The fall in exhaled nitric oxide with ventilation at low lung volumes in rabbits: an index of small airway injury
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Universita degli Studi di Milano, 20133 Milan, Italy
    Respir Physiol Neurobiol 160:215-23. 2008
    ....
  3. ncbi Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension
    Isabel Blanco
    Department of Pulmonary Medicine, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona
    Am J Respir Crit Care Med 181:270-8. 2010
    ..However, vasodilators may inhibit hypoxic pulmonary vasoconstriction and impair gas exchange in this condition...
  4. ncbi Cardiac reserve and pulmonary gas exchange kinetics in patients with stroke
    Corey R Tomczak
    Faculty of Rehabilitation Medicine, University of Alberta, Edmonton AB, Canada
    Stroke 39:3102-6. 2008
    ..We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects.
  5. ncbi Exercise pathophysiology in patients with primary pulmonary hypertension
    X G Sun
    Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
    Circulation 104:429-35. 2001
    ..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
  6. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
    The literature on pulmonary gas exchange at rest, during exercise, and with weight loss in the morbidly obese (body mass index or BMI > or = 40 kg m(-2)) is reviewed...
  7. ncbi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
    ..In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction...
  8. ncbi Influence of exogenous fat emulsion on pulmonary gas exchange after major surgery
    Souji Sane
    First Department of Surgery, Kagoshima University School of Medicine, 8 35 1, Sakuragaoka, Kagoshima 890 8520, Japan
    World J Surg 26:297-302. 2002
    ..The aim of this study was to evaluate the influence of exogenous fat emulsion on pulmonary gas exchange in the early period after major surgery...
  9. ncbi Sigh in supine and prone position during acute respiratory distress syndrome
    Paolo Pelosi
    Dipartimento di Scienze Cliniche e Biologiche, , Ospedale di Circolo, Fondazione Macchi, Varese
    Am J Respir Crit Care Med 167:521-7. 2003
    ..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
  10. ncbi Understanding pulmonary gas exchange: ventilation-perfusion relationships
    John B West
    Am J Physiol Lung Cell Mol Physiol 287:L1071-2. 2004
    ..Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949 (http://ajplegacy.physiology.org/cgi/reprint/158/1/21)). Riley RL...
  11. ncbi Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
    ..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
  12. ncbi Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study
    B Koch
    Medical Faculty of the Ernst Moritz Arndt University, Dept of Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Str 23, D 17475 Greifswald, Germany
    Eur Respir J 33:389-97. 2009
    ..While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey...
  13. ncbi Exercise hypercapnia in advanced chronic obstructive pulmonary disease: the role of lung hyperinflation
    Denis E O'Donnell
    Respiratory Investigation Unit, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 166:663-8. 2002
    ..816, p < 0.0005). In severe COPD, the propensity to develop carbon dioxide retention during exercise reflects marked ventilatory constraints as a result of lung hyperinflation as well as reduced gas exchange capabilities...
  14. ncbi Thin-section CT abnormalities and pulmonary gas exchange impairment in workers exposed to asbestos
    Andrea Sette
    Pulmonary Function and Clinical Exercise Physiology Unit, Div of Respiratory Diseases, , Rua Professor Francisco de Castro 54, Vila Clementino, , Brazil
    Radiology 232:66-74. 2004
    ..To evaluate the relationship between abnormalities at thin-section computed tomography (CT) and indexes of pulmonary gas exchange impairment at rest and during moderate exercise in workers exposed to asbestos...
  15. ncbi Intrapulmonary shunting and pulmonary gas exchange during normoxic and hypoxic exercise in healthy humans
    Andrew T Lovering
    Department of Human Physiology, 1240 University of Oregon, Eugene, OR 97403 1240, USA
    J Appl Physiol 104:1418-25. 2008
    ..were made into a peripheral vein at rest and during exercise and recovery (3-5 min postexercise) with pulmonary gas exchange measured simultaneously...
  16. ncbi Teaching pulmonary gas exchange physiology using computer modeling
    Kent S Kapitan
    Division of Pulmonary Medicine, School of Medicine, Southern Illinois University, Springfield, Illinois 62794 9636, USA
    Adv Physiol Educ 32:61-4. 2008
    ..To overcome this difficulty, I have developed an interactive computer simulation of pulmonary gas exchange that is web based and allows the student to vary multiple factors simultaneously and observe the final ..
  17. ncbi Oxygen in air (FiO2 0.4) improves gas exchange in young healthy patients during general anesthesia
    Anil Agarwal
    Department of Anesthesia, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Can J Anaesth 49:1040-3. 2002
    ..higher the O(2) concentration the faster is the development of atelectasis, an important cause of impaired pulmonary gas exchange during general anesthesia (GA). We evaluated the effect of ventilation with 0.4 FiO(2) in air, 0...
  18. ncbi Influence of a vital capacity maneuver on pulmonary gas exchange after cardiopulmonary bypass
    G S Murphy
    Departments of Anesthesia and Surgery, Evanston Northwestern Healthcare/Northwestern University, Evanston, IL, USA
    J Cardiothorac Vasc Anesth 15:336-40. 2001
    ..breath (vital capacity maneuver [VCM]), administered at the end of cardiopulmonary bypass (CPB), on pulmonary gas exchange in patients undergoing coronary artery bypass graft surgery...
  19. ncbi Interactions between heart rate variability and pulmonary gas exchange efficiency in humans
    Peter Y W Sin
    Department of Surgery and Anaesthesia, University of Otago, Wellington, New Zealand
    Exp Physiol 95:788-97. 2010
    ..component of heart rate variability (respiratory sinus arrhythmia, RSA) has been associated with improved pulmonary gas exchange efficiency in humans via the apparent clustering and scattering of heart beats in time with the ..
  20. ncbi Influence of age, sex, body size, smoking, and beta blockade on key gas exchange exercise parameters in an adult population
    Sven Glaser
    Medical Faculty of the Ernst Moritz Arndt University, Department of Internal Medicine B Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Friedrich Loeffler Street 23, D 17475 Greifswald, Germany
    Eur J Cardiovasc Prev Rehabil 17:469-76. 2010
    ..This study planned to consider the impact of these factors on CPET values and develop reference equations on the basis of a large-scale population-based survey...
  21. ncbi Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture
    F Staffieri
    Section of Critical Care and Anesthesia, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
    Equine Vet J 41:747-52. 2009
    ..It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange...
  22. ncbi Rapid intravenous infusion of 20 ml/kg saline does not impair resting pulmonary gas exchange in the healthy human lung
    G Kim Prisk
    Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0931, USA
    J Appl Physiol 108:53-9. 2010
    ..We hypothesized that infusion would disrupt pulmonary gas exchange by increasing ventilation/perfusion ((.)VA/(...
  23. ncbi Pulmonary gas exchange during exercise in pigs
    S R Hopkins
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623
    J Appl Physiol 86:93-100. 1999
    ..These data suggest that the pig animal model is well suited for studying the mechanism of exercise-induced VA/Q inequality...
  24. ncbi Experimental critical care in rats: gender differences in anesthesia, ventilation, and gas exchange
    D Torbati
    Division Critical Care Medicine, Miami Children s Hospital, FL 33155 3009, USA
    Crit Care Med 27:1878-84. 1999
    ..To compare normative ventilatory and gas-exchange data and anesthetic requirements in male and female rats subjected to critical care conditions...
  25. ncbi Acute and sustained effects of lucinactant versus poractant-alpha on pulmonary gas exchange and mechanics in premature lambs with respiratory distress syndrome
    Elena Gastiasoro-Cuesta
    Department of Pediatrics, Hospital de Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain
    Pediatrics 117:295-303. 2006
    ..Cardiovascular profiles remained stable in both groups. CONCLUSIONS: Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant...
  26. ncbi Intercomparison of recruitment maneuver efficacy in three models of acute lung injury
    Sung-Chul Lim
    Department of Pulmonary/Critical Care Medicine, Regions Hospital, University of Minnesota, St. Paul, MN, USA
    Crit Care Med 32:2371-7. 2004
    ..Although RM may improve PaO2 in certain injury settings when traditional tidal volumes are used, sustained improvement depends on the post-RM positive end-expiratory pressure value...
  27. ncbi Prone positioning improves oxygenation in post-traumatic lung injury--a prospective randomized trial
    Gregor Voggenreiter
    Department of Trauma Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
    J Trauma 59:333-41; discussion 341-3. 2005
    ..However the oxygenation improved significantly over the first four days of treatment, and the prevalence of ARDS and pneumonia were reduced...
  28. ncbi Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment
    Jeffrey M Halter
    Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Am J Respir Crit Care Med 167:1620-6. 2003
    ..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
  29. ncbi Pressure/volume curves and lung computed tomography in acute respiratory distress syndrome
    J J Rouby
    Reanimation Chirurgicale Pierre Viars, Dept of Anesthesiology, Hospital Pitié Salpêtrière, University Paris VI, Paris, France
    Eur Respir J Suppl 42:27s-36s. 2003
    ..In such patients, alveolar recruitment resulting from positive end-expiratory pressure >10 cmH2O is preceded and accompanied by lung overinflation...
  30. ncbi Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines
    Eric K Chu
    Department of Medicine and Critical Care Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada
    Crit Care Med 32:168-74. 2004
    ..With high-volume ventilation, over time, the degree of overdistension is more associated with increases in bronchoalveolar lavage cytokines than cyclic opening and closing alone...
  31. ncbi Non-invasive estimation of shunt and ventilation-perfusion mismatch
    Søren Kjaergaard
    Department of Anaesthesiology, Aalborg Hospital, Aarhus University Hospitals, 9000 Aalborg, Denmark
    Intensive Care Med 29:727-34. 2003
    To investigate whether parameters describing pulmonary gas exchange (shunt and ventilation-perfusion mismatch) can be estimated consistently by the use of non-invasive data as input to a mathematical model of oxygen transport.
  32. ncbi Effect of air and heliox as carrier gas on CO2 transport in a model of high-frequency oscillation comparing two oscillators
    Reinout J Mildner
    Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Crit Care Med 31:1759-63. 2003
    ..Using heliox as carrier gas significantly augmented CO(2) transport, but the increase is frequency and device dependent. The effect of heliox on oscillator performance and the clinical applicability of our findings require further study...
  33. ncbi Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevance
    Dan S Karbing
    Center for Model Based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4 215, DK 9220 Aalborg East, Denmark
    Crit Care 11:R118. 2007
    ....
  34. ncbi Effect of transjugular intrahepatic portosystemic shunt on pulmonary gas exchange in patients with portal hypertension and hepatopulmonary syndrome
    Graciela Martinez-Palli
    Servei d'Anestesiologia i Reanimacio Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    World J Gastroenterol 11:6858-62. 2005
    AIM: To assess the impact of transjugular intrahepatic portosystemic shunt (TIPS) on pulmonary gas exchange and to evaluate the use of TIPS for the treatment of hepatopulmonary syndrome ( HPS )...
  35. ncbi Relation between PaO2/FIO2 ratio and FIO2: a mathematical description
    Jerome Aboab
    , AP-HP, , 51, , , France
    Intensive Care Med 32:1494-7. 2006
  36. ncbi The effects of anesthesia and muscle paralysis on the respiratory system
    Goran Hedenstierna
    Clinical Physiology, Department of Medical Sciences, University Hospital, 75185 Uppsala, Sweden
    Intensive Care Med 31:1327-35. 2005
    ..Moreover, postoperative lung complications occur in 3-10% after elective abdominal surgery and more in emergency operations...
  37. ncbi Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome
    Stefania Redolfi
    Respiratory Medicine Unit, University of Brescia, Piazzale Spedali Civili 1, 25100 Brescia, Italy
    Respir Med 101:1191-5. 2007
    ..The aim of the study was to investigate the role of leptin in the OHS pathogenesis looking at its relationship to CO(2) sensitivity before and after NIMV in OHS patients...
  38. ncbi Recruitment maneuvers attenuate repeated derecruitment-associated lung injury
    Won-Jung Koh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Crit Care Med 33:1070-6. 2005
    ..005). CONCLUSIONS: These findings suggest that repeated derecruitments could induce lung injuries during mechanical ventilation, and recruitment maneuvers may attenuate derecruitment-associated lung injuries...
  39. ncbi Intra-pulmonary shunt and pulmonary gas exchange during exercise in humans
    Michael K Stickland
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    J Physiol 561:321-9. 2004
    ..These results indicate that anatomical I-P shunts develop during exercise and we suggest that shunt recruitment may contribute to the widened A-aDO(2) during exercise...
  40. ncbi Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome
    Richard H Kallet
    Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco, USA
    Respir Care 49:1008-14. 2004
    ..35 and 0.55. However, VD/VT has seldom been measured with consideration to the evolving pathophysiology of ARDS...
  41. ncbi Pulmonary perfusion in the prone and supine postures in the normal human lung
    G Kim Prisk
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0931, USA
    J Appl Physiol 103:883-94. 2007
    Prone posture increases cardiac output and improves pulmonary gas exchange. We hypothesized that, in the supine posture, greater compression of dependent lung limits regional blood flow...
  42. ncbi Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, Sect 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R1202-8. 2004
    We aimed to test effects of altitude acclimatization on pulmonary gas exchange at maximal exercise...
  43. ncbi Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome
    Joao B Borges
    Respiratory Intensive Care Unit, Pulmonary Department, and General Intensive Care Unit, Emergency Clinics Division, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
    Am J Respir Crit Care Med 174:268-78. 2006
    ..The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an efficient maneuver to minimize it...
  44. ncbi Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids
    Philipp Markart
    Department of Internal Medicine, Faculty of Medicine, University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
    Thorax 62:588-94. 2007
    ..Extensive biochemical and biophysical changes of the pulmonary surfactant system occur in the acute respiratory distress syndrome (ARDS)...
  45. ncbi The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling
    Lisbet Niklason
    Department of Clinical Physiology, University Hospital, Getingevagen 4, SE 221 85 Lund, Sweden
    Crit Care 12:R53. 2008
    ..The purpose of the present study was to analyze the extent to which shunt contributes to alveolar dead space and perturbs carbon dioxide exchange in ancillary physiological disturbances...
  46. ncbi Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis
    Nicholas Hart
    Pediatric Pulmonary Department, Armand Trousseau Hospital-AP-HP INSERM E 0213, Paris
    Am J Respir Crit Care Med 166:61-6. 2002
    ..1). As FEV(1) declines in children and young adults with CF, there is an increase in the elastic load and work of breathing, resulting in a rapid shallow breathing pattern, that is associated with further impairment of gas exchange...
  47. ncbi Recruitment maneuvers during lung protective ventilation in acute respiratory distress syndrome
    Ana Villagra
    Critical Care Center, Hospital de Sabadell, Corporacio Parc Tauli, Sabadell, Spain
    Am J Respir Crit Care Med 165:165-70. 2002
    ..In ARDS patients ventilated with a lung protective strategy we conclude that RM have no short-term benefit on oxygenation, and regional alveolar overdistension capable of redistributing blood flow can occur during RM...
  48. ncbi Mechanisms of pulmonary gas exchange improvement during a protective ventilatory strategy in acute respiratory distress syndrome
    M Mancini
    Servei de Pneumologia (ICPCT, , , , Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Am J Respir Crit Care Med 164:1448-53. 2001
    ..04). We conclude that the decrease in intrapulmonary shunt owing to alveolar recruitment remains the pivotal mechanism to explain improvement of arterial oxygenation during this PVS...
  49. ncbi Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation
    Y Imai
    Pathophysiology Research Laboratory, National Children's Medical Research Center, 3-35-31 Taishido, Setagaya-ku, Tokyo 154-8509, Japan
    J Appl Physiol 91:1836-44. 2001
    ..Conventional mechanical ventilation using lung protection strategies (low V(T) high PEEP) only attenuated the decrease in oxygenation and pulmonary compliance. Therefore, HFOV may be a preferable option as a lung protection strategy...
  50. ncbi Influence of prone position on gastric mucosal-arterial PCO2 gradients
    P Kiefer
    Universitat Ulm, Universitätsklinik für Anästhesiologie, Donau, Germany
    Intensive Care Med 27:1227-30. 2001
    ..To evaluate the effects of mechanical ventilation in the prone position on gastric mucosal-arterial PCO2 gradients...
  51. ncbi Repetitive high-pressure recruitment maneuvers required to maximally recruit lung in a sheep model of acute respiratory distress syndrome
    Y Fujino
    Respiratory Care Department Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Crit Care Med 29:1579-86. 2001
    ..Multiple recruitment maneuvers in some animals were required for maximum effect...
  52. ncbi Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury
    A Katz
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 164:260-4. 2001
    ..Although heliox improved gas exchange during HFOV in our model, increased tidal volume delivery may limit clinical applicability...
  53. ncbi Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  54. ncbi Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndrome
    L M Malbouisson
    , Department of Anesthesiology, , , University of Paris VI, 75013 Paris, France
    Am J Respir Crit Care Med 163:1444-50. 2001
    ..76, p = 0.003), suggesting that it may be more accurate than Gattinoni's method...
  55. ncbi Relationship between body and leg VO2 during maximal cycle ergometry
    D R Knight
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623
    J Appl Physiol 73:1114-21. 1992
    ..We conclude that the asymptotic behavior of whole body VO2 at maximal WRs is a direct reflection of the VO2 profile at the exercising legs...
  56. ncbi Regional distribution of gas and tissue in acute respiratory distress syndrome. I. Consequences for lung morphology. CT Scan ARDS Study Group
    L Puybasset
    Department of Anesthesiology, Hopital de la Pitie Salpetriere, University of Paris VI and Institut National des Télécommunications, Evry, France
    Intensive Care Med 26:857-69. 2000
    ..To compare the computed tomographic (CT) analysis of the distribution of gas and tissue in the lungs of patients with ARDS with that in healthy volunteers...
  57. ncbi High-frequency ventilation for acute lung injury and ARDS
    J A Krishnan
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Chest 118:795-807. 2000
    ..Second, despite the small VTs, high respiratory rates during HFV allow the maintenance of normal or near-normal PaCO2 levels. In this review, the use of HFV as a lung protective strategy for patients with ALI/ARDS is discussed...
  58. ncbi The automatic lung parameter estimator (ALPE) system: non-invasive estimation of pulmonary gas exchange parameters in 10-15 minutes
    Stephen Edward Rees
    Center for Model Based Medical Decision Support, Aalborg University, Denmark
    J Clin Monit Comput 17:43-52. 2002
    OBJECTIVE: Clinical measurements of pulmonary gas exchange abnormalities might help prevent hypoxaemia and be useful in monitoring the effects of therapy. In clinical practice single parameters are often used to describe the abnormality e...
  59. ncbi Ventilation index and outcome in children with acute respiratory distress syndrome
    G Paret
    Pediatric Intensive Care Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pediatr Pulmonol 26:125-8. 1998
    ..We conclude that the VI provides a reliable prognostic marker in children with ARDS, and its increase above 65 indicates a need for orderly intervention with alternative modalities of care...
  60. ncbi Recruitment maneuver in pulmonary and extrapulmonary experimental acute lung injury
    Douglas R Riva
    Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Crit Care Med 36:1900-8. 2008
    ..The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models of pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes...
  61. ncbi Pulmonary gas exchange response to weaning with pressure-support ventilation in exacerbated chronic obstructive pulmonary disease patients
    Miquel Ferrer
    Servei de Pneumologia i Al lèrgia Respiratoria, Institut Clinic de Pneumologia i Cirurgia Toracica, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, 08036, Barcelona, Spain
    Intensive Care Med 28:1595-9. 2002
    ....
  62. ncbi Quantitative measurement of regional lung ventilation using 3He MRI
    Anselm J Deninger
    Amersham Health R and D, Medeon, SE - 205 12 Malm, Sweden
    Magn Reson Med 48:223-32. 2002
    ..The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values...
  63. ncbi Repeated derecruitments accentuate lung injury during mechanical ventilation
    Gee Young Suh
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Korea
    Crit Care Med 30:1848-53. 2002
    ..92 +/- 0.78) than both control (0.50 +/- 0.50) and nonderecruitment (0.78 +/- 0.42) groups (p <.05). CONCLUSION: Repeated derecruitments can accentuate lung injury during mechanical ventilation...
  64. ncbi Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury
    Scott E Sinclair
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, BB 1253 HSB Box 356522, Seattle, WA 98195 6522, USA
    Am J Respir Crit Care Med 166:403-8. 2002
    ..18 x 10(5) versus 2.84 x 10(5) +/- 0.28 x 10(5) nucleated cells/ml; p = 0.021), and injury score (7.0 +/- 3.3 versus 0.7 +/- 0.9; p < 0.0001). We conclude that hypercapnic acidosis is protective against VILI in this model...
  65. ncbi Detection of the anaerobic threshold by surface electromyography
    Roger G T Mello
    Biomed Eng Program, Fed Univ of Rio de Janeiro, Rio de Janeiro, Brazil
    Conf Proc IEEE Eng Med Biol Soc 1:6189-92. 2006
    ..The method was successful to determine SEMG-T for all subjects, with consistent results when compared to respective anaerobic thresholds visually estimated in the ventilatory equivalent V(E)/VO(2)...
  66. ncbi Cardiac and ventilatory responses to apneic exercise
    Jens Wein
    Department of Ecology, Biocentre Grindel, Hamburg University, Martin Luther King Platz 3, Hamburg, Germany
    Eur J Appl Physiol 100:637-44. 2007
    ....
  67. ncbi Estimation of arterial PCO2 from a lung model during ramp exercise in healthy young subjects
    Vincent Thomas
    Unité de Recherche Physiologie et Physiopathologie de L exercice et Handicap, Université Jean Monnet, Saint Etienne, France
    Respir Physiol Neurobiol 156:259-65. 2007
    ..001). It is concluded that, on the basis of the bias, the breathing lung model gave better estimates of P(a)CO2 than the two other indirect methods during ramp exercise...
  68. ncbi Short-term cardiorespiratory effects of proportional assist and pressure-support ventilation in patients with acute lung injury/acute respiratory distress syndrome
    Eumorfia Kondili
    Intensive Care Medicine Department, University Hospital of Heraklion 71110, University of Crete, Heraklion, Crete, Greece
    Anesthesiology 105:703-8. 2006
    Recent data indicate that assisted modes of mechanical ventilation improve pulmonary gas exchange in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)...
  69. ncbi Influence of priming exercise on pulmonary O2 uptake kinetics during transitions to high-intensity exercise from an elevated baseline
    Fred J DiMenna
    School of Sport and Health Sciences, St Luke s Campus, University of Exeter, Heavitree Rd, Exeter, Devon EX1 2LU, United Kingdom
    J Appl Physiol 105:538-46. 2008
    ..b>Pulmonary gas exchange, heart rate, and the electromyogram of m. vastus lateralis were measured during all tests...
  70. ncbi The canine spleen in oxygen transport: gas exchange and hemodynamic responses to splenectomy
    Connie C W Hsia
    Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9034, USA
    J Appl Physiol 103:1496-505. 2007
    ..The relationship between DL(O2) and DL(CO) was unchanged by splenectomy. We conclude that the canine spleen regulates both convective and diffusive O(2) transport during exercise to increase maximal O(2) uptake...
  71. ncbi Effect of internal power on muscular efficiency during cycling exercise
    Masato Tokui
    Department of Sports Science, Faculty of Sports Science, Kyushu Kyoritsu University, 1 8 Jiyugaoka, Yahatanishi ku, Kitakyushu shi, 807 8585, Japan
    Eur J Appl Physiol 101:565-70. 2007
    ..We concluded that muscular efficiency could be affected by the differences in O2 cost and Pint during cycling under the large range of pedal rates employed in this study...
  72. ncbi Effects of "priming" exercise on pulmonary O2 uptake and muscle deoxygenation kinetics during heavy-intensity cycle exercise in the supine and upright positions
    Andrew M Jones
    School of Sport and Health Sciences, University of Exeter, St Luke s Campus, Heavitree Rd, Exeter, EX1 2LU, United Kingdom
    J Appl Physiol 101:1432-41. 2006
    ....
  73. ncbi Role of respiratory system impedance in the difference of ventilatory control between children and adults
    Stefan Keslacy
    820 Comstock Avenue, University of Syracuse, Department of Exercise Science, Room 204 Women s Building, Syracuse, NY 13206, USA
    Respir Physiol Neurobiol 161:239-45. 2008
    ..Reinforced by the significant correlation between tau VE and tau P0.1/VT/Ti for children but not adults, we concluded that ventilatory response differences could be due in part to the respiratory system impedance...
  74. ncbi Flex: a new computerized system for mechanical ventilation
    Fleur T Tehrani
    Department of Electrical Engineering, California State University, Fullerton, CA, USA
    J Clin Monit Comput 22:121-30. 2008
    ..To describe and evaluate a new weaning and decision support system for mechanical ventilation...
  75. ncbi Pressure-controlled ventilation improves oxygenation during laparoscopic obesity surgery compared with volume-controlled ventilation
    P Cadi
    Department of Anaesthesia and Intensive Care Unit, Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, 20 40, rue Leblanc, 75908 Paris Cedex 15, France
    Br J Anaesth 100:709-16. 2008
    ..We compared pressure and volume-controlled ventilation (PCV and VCV) in morbidly obese patients undergoing laparoscopic gastric banding surgery...
  76. ncbi Software for interpreting cardiopulmonary exercise tests
    Robert M Ross
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    BMC Pulm Med 7:15. 2007
    ..However, interpreting these tests is often difficult and time consuming, requiring significant expertise...
  77. ncbi Determinants of maximal oxygen uptake in moderate acute hypoxia in endurance athletes
    Pascal Mollard
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 74 rue Marcel Cachin, EA2363, ARPE, 93017 Bobigny Cedex, France
    Eur J Appl Physiol 100:663-73. 2007
    ..VEmax at 4,500 m (2) the greater.QaO2max decrement in TS due to a lower Sa'O2max and unchanged .Qmax 3) the smaller increase in O2ERmax in TS, insufficient to compensate the decrease in .QaO2max...
  78. ncbi Mechanisms of exertional dyspnea in patients with cancer
    J Travers
    Respiratory Investigation Unit, Division of Respiratory and Critical Care Medicine, Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 104:57-66. 2008
    ..05). There were no significant between-group differences in measurements of airway function, pulmonary gas exchange, or cardiovascular function during exercise...
  79. ncbi Estimation of the exercise ventilatory compensation point by the analysis of the relationship between minute ventilation and heart rate
    Paolo Onorati
    Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universita La Sapienza, Viale dell Universita 37, Rome, Italy
    Eur J Appl Physiol 104:87-94. 2008
    ..VCP occurred at the same percentage of peak V'O(2) in both protocols. The changes in the V'(E) versus HR slope during incremental exercise can be used to detect the VCP as alternative to the ventilatory equivalents method...
  80. ncbi Physiological characteristics of badminton match play
    Oliver Faude
    Institute of Sports and Preventive Medicine, Faculty of Clinical Medicine, University of Saarland, Campus Bldg B 8 2, 66123, Saarbrucken, Germany
    Eur J Appl Physiol 100:479-85. 2007
    ..A well-developed aerobic endurance capacity seems necessary for fast recovery between rallies or intensive training workouts...
  81. ncbi Validation and application of a high-fidelity, computational model of acute respiratory distress syndrome to the examination of the indices of oxygenation at constant lung-state
    R A McCahon
    University Department of Anaesthesia, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Anaesth 101:358-65. 2008
    ..The study is the first step in developing an accurate and non-invasive tool to quantify oxygenation defects...
  82. ncbi Respiratory and haemodynamic effects of volume-controlled vs pressure-controlled ventilation during laparoscopy: a cross-over study with echocardiographic assessment
    C C Balick Weber
    Service of Anaesthesiology, Pointe A Pitre cedex, France
    Br J Anaesth 99:429-35. 2007
    ..This prospective cross-over study was undertaken to compare how volume-controlled (VC) and PC modes could affect pulmonary mechanics, gas exchange, and cardiac function in patients undergoing laparoscopy...
  83. ncbi Electrostimulation improves muscle perfusion but does not affect either muscle deoxygenation or pulmonary oxygen consumption kinetics during a heavy constant-load exercise
    Gwenael Layec
    Faculte de Medecine de Marseille, Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, 27 Bd Jean Moulin, 13005, Marseille, France
    Eur J Appl Physiol 102:289-97. 2008
    ..These results suggest that improved O(2) delivery by residual hyperaemia induced by EMS does not accelerate the rate of aerobic metabolism during heavy exercise at least in trained subjects...
  84. ncbi Exhaled nitric oxide level during and after heavy exercise in athletes with exercise-induced hypoxaemia
    Pascale Kippelen
    Laboratoire de Physiologie des Interactions, Service de Physiologie Clinique, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5, France
    Pflugers Arch 444:397-404. 2002
    ..However, potential NO epithelial down-regulation may occur and contribute to the development of gas exchange abnormality in some endurance-trained athletes...
  85. ncbi Estimate of pulmonary diffusing capacity for oxygen during exercise in humans from routine O(2) and CO(2) measurements
    M F Vidal Melo
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02461, USA
    Clin Physiol Funct Imaging 24:46-57. 2004
    ..The method may be an alternative for estimates of D(LO2) during exercise...
  86. ncbi Permissive hypercapnia
    Ulrich H Thome
    Division of Neonatology and Pediatric Critical Care, Children's Hospital, University of Ulm, 89070 Ulm, Germany
    Semin Neonatol 7:409-19. 2002
    ..Herein, we review the mechanisms leading to lung injury, the physiologic effects of hypercapnia, the dangers of hypocapnia, and the available clinical data...
  87. ncbi Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury
    Guangfa Zhu
    Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai, China
    J Appl Physiol 96:1415-24. 2004
    ..either treatment alone. These results indicate that combined treatment of TGI and PLV results in improved pulmonary outcome than either treatment alone in this animal model of ALI...
  88. ncbi Chemoreflex drive and the dynamics of ventilation and gas exchange during exercise at hypoxia
    Yoshiyuki Fukuoka
    Laboratory of Environmental Applied Physiology, Faculty of Environmental and Symbiotic Science, Prefectural University of Kumamoto, Kumamoto 862 8502, Japan
    Am J Respir Crit Care Med 168:1115-22. 2003
    ..Otherwise, O(2) uptake dynamics are affected by the lower O(2), not by the changing work rates under hypoxic conditions...
  89. ncbi Chest wall disruption with and without acute lung injury: effects of continuous positive airway pressure therapy on ventilation and perfusion relationships
    John W Schweiger
    Department of Anesthesiology, College of Medicine, University of South Florida, Tampa 33612, USA
    Crit Care Med 31:2364-70. 2003
    ....
  90. ncbi The effect of prolonged submaximal exercise on gas exchange kinetics and ventilation during heavy exercise in humans
    Stephane Perrey
    , , 700 Av. du pic St Loup, 34090 Montpellier Cedex, France
    Eur J Appl Physiol 89:587-94. 2003
    ....
  91. ncbi Maximal exercise testing in late gestation: maternal responses
    A P Heenan
    School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada
    Obstet Gynecol 97:127-34. 2001
    ..However, carbohydrate utilization might be blunted at high levels of exertion. Blunted respiratory responses were attributed to reduced lactate production and/or dilution of lactate in an expanded blood volume...
  92. ncbi Pulmonary involvement in type 1 Gaucher disease: functional and exercise findings in patients with and without clinical interstitial lung disease
    A Miller
    Division of Pulmonary and Critical Care Medicine, Mount Sinai Medical Center, New York, NY, USA
    Clin Genet 63:368-76. 2003
    ..In addition, we found that some patients, without evident lung involvement, may experience limitations in physical exertion and are easily fatigued; this is attributable to impaired circulation...
  93. ncbi Lung recruitment manoeuvres are effective in regaining lung volume and oxygenation after open endotracheal suctioning in acute respiratory distress syndrome
    Thomas Dyhr
    Research Fellow, Section of Intensive Care Medicine, Department of Anaesthesiology, Gentofte University Hospital, Hellerup, Denmark
    Crit Care 7:55-62. 2003
    ..Lung recruitment (LR) manoeuvres may be effective in rapidly regaining lung volume and improving oxygenation after ETS...
  94. ncbi Muscle oxygenation and pulmonary gas exchange kinetics during cycling exercise on-transitions in humans
    Bruno Grassi
    Dipartimento di Scienze e Tecnologie Biomediche, School of Medicine, University of Milan, Milan, Italy
    J Appl Physiol 95:149-58. 2003
    ..The lack of a drop in muscle oxygenation at the transition suggests adequacy of O2 availability in relation to needs...
  95. ncbi Prognostic power of ventilatory responses during submaximal exercise in patients with chronic heart disease
    Akira Koike
    Cardiovascular Institute, Tokyo, Japan
    Chest 121:1581-8. 2002
    ..For this purpose, we aimed to determine the best index among exercise variables in predicting long-term mortality in patients with chronic heart disease...
  96. ncbi Effects of prone and supine posture on cardiopulmonary function after experimental chlorine gas lung injury
    J Wang
    Section of Disaster Medicine, Department of Biomedicine and Surgery, Faculty of Health Sciences, University of Linkoping, Cardiothoracic Intensive Care Unit, University Hospital, Linkoping, Sweden
    Acta Anaesthesiol Scand 46:1094-102. 2002
    Chlorine gas may induce severe acute lung injury. Improvement of pulmonary gas exchange in patients and animals with acute lung injury nursed in the prone position was observed in recent years...
  97. ncbi Partial liquid ventilation in severely surfactant-depleted, spontaneously breathing rabbits supported by proportional assist ventilation
    U H Thome
    Division of Neonatology and Pediatric Critical Care, University Children's Hospital, 89070 Ulm, Germany
    Crit Care Med 29:1175-80. 2001
    ..CONCLUSIONS: PLV improved oxygenation and pulmonary compliance in spontaneously breathing, severely surfactant-depleted rabbits supported by PAV. The severity of lung injury by histology was unaffected...
  98. ncbi A metabolic cart for measurement of oxygen uptake during human exercise using inspiratory flow rate
    Kurt Jensen
    Team Danmarks Testcenter, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense University, Campusvej 55, 5230 Odense M, Denmark
    Eur J Appl Physiol 87:202-6. 2002
    ..4% and it is concluded that a metabolic cart method based on inspiratory flow rate is suitable for measurement of VO(2) and V(E) during both submaximal and maximal exercise...
  99. ncbi Validity and reliability of three commercially available breath-by-breath respiratory systems
    James Carter
    Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    Eur J Appl Physiol 86:435-41. 2002
    ..8-45.8%). The exercise study showed the Oxycon Pro and Oxycon Alpha to be both valid and reliable on-line systems for the measurement of parameters of respiration, at least at workloads up to 150 W...
  100. ncbi Walking modality affects respiratory muscle action and contribution to respiratory effort
    Roberto Duranti
    Department of Internal Medicine, Section of Clinical Immunology, Allergology and Respiratory Diseases, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Pflugers Arch 448:222-30. 2004
    ..Combinations of different patterns of flow and pressure generation made the respiratory effort sensation similar during AS and AG modes...
  101. ncbi The effect of varied fractional inspired oxygen on arm exercise performance in spinal cord injury and able-bodied persons
    Maria T Hopman
    Department of Physiology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Arch Phys Med Rehabil 85:319-23. 2004
    ..To examine the effect of different levels of fractional inspired oxygen (FiO(2)) (15%, 21%, 50%) on peak oxygen consumption (VO(2)peak) during arm exercise in persons with spinal cord injury and in able-bodied controls...

Research Grants114 found, 100 shown here

  1. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2006
    ..abstract_text> ..
  2. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. ..
  3. STRESS FAILURE AND REMODELING IN PULMONARY CAPILLARIES
    John West; Fiscal Year: 2003
    ..In addition, at the more basic level, this research is devoted to a fundamental bioengineering dilemma of the lung, namely, that the blood-gas barrier has to combine extreme thinness with immense strength. ..
  4. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2007
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  5. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..understand the mechanisms by which pulmonary interstitial edema, the precursor to alveolar edema, affects pulmonary gas exchange. Pulmonary interstitial edema in the lung occurs as part of the transition between a healthy "dry" state, ..
  6. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  7. NON-G DETERMINANTS OF PULMONARY PERFUSION HETEROGENEITY
    Robb Glenny; Fiscal Year: 2000
    ..In addition to this new information on basic lung function, pulmonary perfusion distributions can now be explored in small-animal disease models. ..
  8. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan Hopkins; Fiscal Year: 2007
    ....
  9. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  10. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2007
    ..abstract_text> ..
  11. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  12. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2010
    ..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..
  13. REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURY
    Guido Musch; Fiscal Year: 2007
    ..End of Abstract) ..
  14. Airway Hyper-responsiveness: from molecule to organ
    Merryn Tawhai; Fiscal Year: 2007
    ..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
  15. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....
  16. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2007
    ..and macrovascular levels, and to thereby provide insight into the mechanisms by which RBCs affect pulmonary gas exchange. The knowledge gained from this project will have health-related ramifications, in that it will allow more ..
  17. Study of Acid Reflux Therapy for Children with Asthma
    WILLIAM TEAGUE; Fiscal Year: 2007
    ..The results of this trial should have a major impact on the understanding and treatment of GER in children with asthma. ..
  18. Mechanisms of innate immune response modulation by mechanical ventilation
    William A Altemeier; Fiscal Year: 2010
    ..This project will help identify mechanisms by which mechanical ventilation support causes lung injury;thereby, providing guidance for the development of future interventions to decrease the incidence and severity of acute lung injury. ..
  19. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  20. Mitochondrial biogenesis in sepsis-induced organ dysfunction
    KAREN E contact WELTY WOLF; Fiscal Year: 2010
    ..These studies will investigate the role of mitochondrial injury and biogenesis in the pathogenesis of organ dysfunction in sepsis, and should lead to new therapies to enhance recovery from organ failures in sepsis. ..
  21. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  22. COPD Clinical Research Network & Clinical Research Skills Core Development
    Gerard Criner; Fiscal Year: 2007
    ..abstract_text> ..
  23. PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury
    Marcos F Vidal Melo; Fiscal Year: 2010
    ..abstract_text> ..
  24. Sensitive and Specific Molecular Imaging of Pulmonary Nodules
    BASTIAAN contact DRIEHUYS; Fiscal Year: 2010
    ..The proposed research has relevance to public health because new tools in imaging pulmonary cancers will not only improve patient treatment, but will also accelerate research to develop better therapies. ..
  25. PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury
    MARCOS VIDAL MELO; Fiscal Year: 2009
    ..abstract_text> ..
  26. Dynamics of Vascular Microbubbles and Microdroplets in Gas Embolotherapy
    JOSEPH BULL; Fiscal Year: 2007
    ..This approach could potentially be used to treat a variety of cancers and uterine fibroids. ..
  27. Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
    Machiko Ikegami; Fiscal Year: 2010
    ..Furthermore, the molecular mechanisms, in particular the signaling pathways regulating Cebpa, of recombinant human FGF-7 treatment for acute lung injury will be determined. ..
  28. CGMP REGULATION IN THE DEVELOPING PULMONARY VASCULATURE
    Robin Steinhorn; Fiscal Year: 2007
    ..To accomplish specific aim 2, we will primarily use in vivo studies to test the hypothesis that scavenging superoxide with rhSOD increases endogenous NO production via changes in NOS expression and/or activity. ..
  29. Exercise for Mental Health: Does Exercise Make People Feel Better?
    Panteleimon Ekkekakis; Fiscal Year: 2003
    ..The immediate anticipated benefit of this research is the development of physical activity public health recommendations that incorporate affect as a fundamental consideration. ..
  30. VITAMIN A EFFECTS ON ALVEOLAR FORMATION
    KURT ALBERTINE; Fiscal Year: 2002
    ..The experiments also should help establish the molecular basis for the potentially therapeutic benefit of retinoids. ..
  31. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    KURT ALBERTINE; Fiscal Year: 2001
    ....
  32. Hormonal Control of Lung Development: PTHrP Biology
    John Torday; Fiscal Year: 2003
    ..Understanding these mechanisms will enhance knowledge as to how stem cell function in lung injury/repair, and how they may be used effectively to treat lung injury and chronic lung disease in infants. ..
  33. PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury
    MARCOS VIDAL MELO; Fiscal Year: 2007
    ....
  34. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  35. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. ..
  36. HORMONAL CONTROL OF LUNG DEVELOPMENT--PTHRP BIOLOGY
    John Torday; Fiscal Year: 1999
    ....