bronchoscopy

Summary

Summary: Endoscopic examination, therapy or surgery of the bronchi.

Top Publications

  1. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
  2. ncbi The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system
    Taiki Fujiwara
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Chest 138:641-7. 2010
  3. ncbi Bronchial anthracofibrosis: an emerging pulmonary disease due to biomass fuel exposure
    A Gupta
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Int J Tuberc Lung Dis 15:602-12. 2011
  4. ncbi Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer
    Bin Hwangbo
    Center for Lung Cancer, National Cancer Center, Goyang, Korea
    Chest 138:795-802. 2010
  5. ncbi Confocal fluorescence endomicroscopy of the human airways
    Luc Thiberville
    Rouen University Hospital, CHU de Rouen, 1 rue de Germont, 76031 Rouen Cedex, France
    Proc Am Thorac Soc 6:444-9. 2009
  6. ncbi Tracheobronchial foreign body aspiration in children: how reliable are clinical and radiological signs in the diagnosis?
    F T Orji
    Department of Otolaryngology, University of Nigeria Teaching Hospital Enugu, Enugu, Nigeria
    Clin Otolaryngol 35:479-85. 2010
  7. pmc Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study
    Neal Navani
    Centre for Respiratory Research, University College London, 5 University Street, London WC1E 6JJ, UK
    Thorax 66:889-93. 2011
  8. ncbi Vascular image patterns of lymph nodes for the prediction of metastatic disease during EBUS-TBNA for mediastinal staging of lung cancer
    Takahiro Nakajima
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    J Thorac Oncol 7:1009-14. 2012
  9. ncbi Electromagnetic navigation diagnostic bronchoscopy in peripheral lung lesions
    Ralf Eberhardt
    Department of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Germany
    Chest 131:1800-5. 2007
  10. ncbi The utility of bronchoscopy after inhalation injury complicated by pneumonia in burn patients: results from the National Burn Repository
    John Alfred Carr
    Division of Trauma and Burn Surgery, Hurley Medical Center, Flint, Michigan 48503, USA
    J Burn Care Res 30:967-74. 2009

Detail Information

Publications352 found, 100 shown here

  1. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..Our study showed a close link between smoking and expression of TGF-beta1 in small airways. Our results also suggested that small airway epithelial cells might be involved in obstructive changes found in smokers and patients with COPD...
  2. ncbi The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system
    Taiki Fujiwara
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Chest 138:641-7. 2010
    ....
  3. ncbi Bronchial anthracofibrosis: an emerging pulmonary disease due to biomass fuel exposure
    A Gupta
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Int J Tuberc Lung Dis 15:602-12. 2011
    ....
  4. ncbi Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer
    Bin Hwangbo
    Center for Lung Cancer, National Cancer Center, Goyang, Korea
    Chest 138:795-802. 2010
    ....
  5. ncbi Confocal fluorescence endomicroscopy of the human airways
    Luc Thiberville
    Rouen University Hospital, CHU de Rouen, 1 rue de Germont, 76031 Rouen Cedex, France
    Proc Am Thorac Soc 6:444-9. 2009
    ..This article reviews the capabilities and possible limitations of confocal microendoscopy for in vivo proximal and distal lung explorations...
  6. ncbi Tracheobronchial foreign body aspiration in children: how reliable are clinical and radiological signs in the diagnosis?
    F T Orji
    Department of Otolaryngology, University of Nigeria Teaching Hospital Enugu, Enugu, Nigeria
    Clin Otolaryngol 35:479-85. 2010
    ..To evaluate the yield of clinical and radiological features in the diagnosis of suspected foreign body aspiration in children and to assess factors associated with delayed diagnosis of foreign body aspiration...
  7. pmc Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study
    Neal Navani
    Centre for Respiratory Research, University College London, 5 University Street, London WC1E 6JJ, UK
    Thorax 66:889-93. 2011
    ..The aim of this study was to describe the diagnostic utility of EBUS-TBNA in patients with intrathoracic lymphadenopathy due to tuberculosis (TB)...
  8. ncbi Vascular image patterns of lymph nodes for the prediction of metastatic disease during EBUS-TBNA for mediastinal staging of lung cancer
    Takahiro Nakajima
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    J Thorac Oncol 7:1009-14. 2012
    ....
  9. ncbi Electromagnetic navigation diagnostic bronchoscopy in peripheral lung lesions
    Ralf Eberhardt
    Department of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Germany
    Chest 131:1800-5. 2007
    Electromagnetic navigation bronchoscopy (ENB) with biopsy under fluoroscopic guidance has enhanced the yield of flexible bronchoscopy in the diagnosis of peripheral lung lesions...
  10. ncbi The utility of bronchoscopy after inhalation injury complicated by pneumonia in burn patients: results from the National Burn Repository
    John Alfred Carr
    Division of Trauma and Burn Surgery, Hurley Medical Center, Flint, Michigan 48503, USA
    J Burn Care Res 30:967-74. 2009
    There are no guidelines to determine when bronchoscopy is appropriate in patients with inhalation injury complicated by pneumonia...
  11. ncbi EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy
    Jouke T Annema
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 48:357-61; discussion 363-4. 2005
    To assess the feasibility and yield of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) in diagnosing centrally located lung tumours after a previously non-diagnostic bronchoscopy.
  12. pmc Foreign body aspiration in children: diagnostic and therapeutic role of bronchoscopy
    Wojciech Korlacki
    Department of Pediatric Surgery in Zabrze, Medical University of Silesia, Katowice, ul 3 Maja 13 15, 41 800, Zabrze, Poland
    Pediatr Surg Int 27:833-7. 2011
    Assessment of bronchoscopy usefulness for diagnosis and treatment in children suspected of foreign body aspiration.
  13. ncbi Respiratory management of inhalation injury
    Ronald P Mlcak
    Respiratory Care Department, Shriners Hospital for Children, Galveston, TX, USA
    Burns 33:2-13. 2007
    ..It is imperative that a well organized, protocol driven approach to respiratory care of inhalation injury be utilized so that improvements can be made and the morbidity and mortality associated with inhalation injury be reduced...
  14. ncbi Foreign body aspiration in children and adolescents: experience of a Brazilian referral center
    Sílvia Teresa Evangelista Vidotto de Sousa
    Centro Universitário do Maranhão, Sao Luis, MA, Brasil
    J Bras Pneumol 35:653-9. 2009
    ..To describe the clinical, radiological and endoscopic characteristics of foreign body aspiration among individuals under the age of 15 treated at a referral center in the city of São Luís, Brazil...
  15. ncbi Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Gerard A Silvestri
    Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    Chest 143:e211S-50S. 2013
    ..Several noninvasive imaging studies and invasive tests are available. Understanding the accuracy, advantages, and disadvantages of the available methods for staging non-small cell lung cancer is critical to decision-making...
  16. ncbi Ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
    Am J Respir Crit Care Med 165:867-903. 2002
    ..When fiberoptic bronchoscopy is not available to physicians treating patients clinically suspected of having VAP, we recommend using either ..
  17. ncbi Management of plastic bronchitis with topical tissue-type plasminogen activator
    Elizabeth Gibb
    Division of Pulmonary Medicine, Department of Pediatrics, Benioff Children s Hospital, University of California San Francisco, San Francisco, California 94143, USA
    Pediatrics 130:e446-50. 2012
    ..with direct instillation of tissue-type plasminogen activator (tPA) to the obstructing casts during flexible bronchoscopy and inhaled tPA. Our case illustrates that the current therapy for plastic bronchitis remains inadequate...
  18. pmc Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule
    Jessica S Wang Memoli
    Section of Pulmonary, Critical Care, and Respiratory Services, Washington Hospital Center, Washington, DC 20010, USA
    Chest 142:385-93. 2012
    ..When tissue diagnosis is desired, transthoracic needle aspiration (TTNA) is recommended. Several guided-bronchoscopy technologies have been developed to improve the yield of transbronchial biopsy for PN diagnosis: ..
  19. pmc Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial
    Neal Navani
    Centre for Respiratory Research, University College London, London, UK
    Am J Respir Crit Care Med 186:255-60. 2012
    ..Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is established as an alternative to mediastinoscopy in patients with lung cancer...
  20. ncbi Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Chest 126:122-8. 2004
    ....
  21. ncbi Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease
    Pascal Chanez
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Proc Am Thorac Soc 1:184-90. 2004
    ..The effects of these drugs on structural changes in COPD have not been investigated extensively. Long-term prospective studies are needed to demonstrate the potential for ICSs to affect the natural history of chronic bronchial diseases...
  22. ncbi Vibration response imaging as a new tool for interventional-bronchoscopy outcome assessment: a prospective pilot study
    Heinrich D Becker
    Department of Interdisciplinary Endoscopy, Thoraxklinik at Heidelberg University, Heidelberg, Germany
    Respiration 77:179-94. 2009
    In many patients, the benefit of interventional bronchoscopy cannot be appropriately objectified.
  23. ncbi Aetiology and presentation of HIV/AIDS-associated pulmonary infections in patients presenting for bronchoscopy at a referral hospital in northern Tanzania
    G S Kibiki
    Department of Internal Medicine, Endoscopy Unit, KCMC, Tumaini University, P O Box 3010, Moshi, Tanzania
    East Afr Med J 84:420-8. 2007
    ..To determine the aetiological agents of pulmonary infections in HIV-infected Tanzanians and to correlate the causative agents with clinical, radiographic features, and mortality...
  24. ncbi The safety of bronchoscopy in a pulmonary fellowship program
    Daniel R Ouellette
    Pulmonary and Critical Care Medicine, Henry Ford Hospital, 2799 West Grand Ave, Detroit, MI 48202, USA
    Chest 130:1185-90. 2006
    To determine the complication rate from supervised training bronchoscopy in a single pulmonary fellowship program, and to examine the effects of fellow and faculty experience on this complication rate.
  25. ncbi Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions
    Takahiro Nakajima
    Departments of Thoracic Surgery and daggerDiagnostic Pathology, Graduate School of Medicine, Chiba University, Japan
    J Thorac Oncol 3:985-8. 2008
    The diagnosis of centrally located intrapulmonary tumors not visible on bronchoscopy may be a challenge...
  26. ncbi Narrow-band imaging bronchoscopy increases the specificity of bronchoscopic early lung cancer detection
    Felix J F Herth
    Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany thoraxklinik heidelberg de
    J Thorac Oncol 4:1060-5. 2009
    ..New bronchoscopic technologies, including white light videobronchoscopy (WLB), autofluorescence imaging (AFI), and narrow band imaging (NBI), are aiming to diagnose airway neoplasia at a preinvasive stage...
  27. pmc Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study
    Neal Navani
    Center for Respiratory Research, University College London, London
    J Thorac Oncol 6:1505-9. 2011
    ..The utility of EBUS-TBNA in patients with extrathoracic malignancy was evaluated...
  28. ncbi Lung volume reduction by bronchoscopic administration of steam
    Michael J Emery
    Veterans Affairs Puget Sound Health Care System and Seattle Institute for Biomedical and Clinical Research, Seattle, Washington, USA
    Am J Respir Crit Care Med 182:1282-91. 2010
    ..However, LVR by these methods is limited by temporary or incomplete collapse and/or residual atelectatic and scarred tissue volumes. Heat-induced ablation of lung tissue is currently under investigation as an alternative LVR methodology...
  29. ncbi Asthma control during the year after bronchial thermoplasty
    Gerard Cox
    St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    N Engl J Med 356:1327-37. 2007
    ..Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma...
  30. ncbi Clinical application of airway bypass with paclitaxel-eluting stents: early results
    Paulo F G Cardoso
    Department of Surgery, Division of Thoracic Surgery, Santa Casa de Porto Alegre Pavilhao Pereira Filho Hospital, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre RS, Brazil
    J Thorac Cardiovasc Surg 134:974-81. 2007
    ..To assess the safety and early clinical results of a multicenter evaluation of airway bypass with paclitaxel-eluting stents for selected patients with severe emphysema...
  31. ncbi Bronchoscopy and needle biopsy techniques for diagnosis and staging of lung cancer
    Peter Mazzone
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Chest Med 23:137-58, ix. 2002
    ..The individual therapeutic approach and prognosis depends on accurate diagnosis and staging. Flexible bronchoscopy (FB) and transthoracic needle biopsy (TNB) are the most widely used techniques for this purpose...
  32. ncbi A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer
    Kazuhiro Yasufuku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 142:1393-400.e1. 2011
    ..The study objective was to compare endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with mediastinoscopy for mediastinal lymph node staging of potentially resectable non-small cell lung cancer...
  33. ncbi Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial
    P L Shah
    National Institute for Health Research Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust, Imperial College, London, UK
    Lancet 378:997-1005. 2011
    ..The aim of the EASE (Exhale airway stents for emphysema) trial was to evaluate safety and efficacy of airway bypass in people with severe homogeneous emphysema...
  34. ncbi Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station?
    Hee Seok Lee
    Center for Lung Cancer, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang, Gyeonggi, 411 764, Korea
    Chest 134:368-74. 2008
    ....
  35. ncbi Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    M Patricia Rivera
    University of North Carolina at Chapel Hill, 4133 Bioinformatics Building, CB No 7020, Chapel Hill, NC 27599, USA
    Chest 132:131S-148S. 2007
    ....
  36. ncbi EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncologic Network, Ghent University Hospital, Ghent, Belgium
    Lung Cancer 63:45-9. 2009
    ..Obtaining a tissue diagnosis of malignancy is challenging in patients with suspected lung cancer presenting with centrally located intrapulmonary masses...
  37. ncbi A feasibility and safety study of bronchoscopic thermal vapor ablation: a novel emphysema therapy
    Gregory I Snell
    Alfred Hospital and Monash University, Melbourne, NSW 3004, Australia
    Ann Thorac Surg 88:1993-8. 2009
    ..This study reports the feasibility and safety of novel second-generation bronchoscopic lung volume reduction (LVR) technology, independent of collateral ventilation...
  38. ncbi Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
    S E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 156:737-43. 1997
    ..These findings suggest that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids which may be due to the severity of disease, glucocorticoid treatment, or other as yet undefined factors...
  39. ncbi Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer
    Jeong Eun Lee
    Department of Internal Medicine, Cancer Research Institute, Chungnam National University, 33 Munhwa ro, Gung gu, Daejeon, 301 721, Republic of Korea
    Lung Cancer 70:51-6. 2010
    ..We performed this study to evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the pathologic diagnosis of lung cancer including lung masses as well as lymph nodes as targets...
  40. ncbi Epithelial damage and angiogenesis in the airways of children with asthma
    Angelo Barbato
    Divisione di Pneumologia, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari Università degli Studi di Padova, Via Giustiniani 3, Padova, Italy
    Am J Respir Crit Care Med 174:975-81. 2006
    ..Airway remodeling and inflammation are characteristic features of adult asthma that are still poorly investigated in childhood asthma...
  41. ncbi The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy
    I Matot
    Department of Anesthesia and Critical Care Medicine, Hadassah University School of Medicine, Jerusalem, Israel
    Anesth Analg 91:828-33. 2000
    The usual hemodynamic response to laryngoscopy and bronchoscopy is an increase in heart rate and arterial blood pressure. Previous work has reported that 10%-18% of the patients develop ischemic ST segment changes during the procedure...
  42. ncbi Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis
    K Adams
    Academic Division of Thoracic Surgery, Imperial College, Royal Brompton Hospital, London SW3 6NP, UK
    Thorax 64:757-62. 2009
    ..A systematic review was performed of published studies evaluating EBUS-TBNA for mediastinal lymph node staging to ascertain the pooled sensitivity and specificity of this investigation...
  43. ncbi Biomass smoke induced bronchial anthracofibrosis: presenting features and clinical course
    Yeon Jae Kim
    Division of Pulmonary and Critical Care Medicine, Fatima Hospital, Daegu, South Korea
    Respir Med 103:757-65. 2009
    ..The presenting features and clinical course of biomass smoke induced bronchial anthracofibrosis (BAF) are not well known...
  44. pmc Electromagnetic navigation diagnostic bronchoscopy: a prospective study
    Thomas R Gildea
    Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 174:982-9. 2006
    Electromagnetic navigation bronchoscopy using superDimension/Bronchus System is a novel method to increase diagnostic yield of peripheral and mediastinal lung lesions.
  45. ncbi Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial
    Ralf Eberhardt
    Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany
    Am J Respir Crit Care Med 176:36-41. 2007
    Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions...
  46. pmc Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study
    Claudia Jafari
    Clinical Infectious Diseases, Research Center Borstel, Borstel Germany
    Am J Respir Crit Care Med 180:666-73. 2009
    ..The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears...
  47. pmc Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Australia
    Clin Exp Immunol 150:22-9. 2007
    ..Systemic therapeutic targeting of TNF-alpha production by CD8(+) T cells may improve morbidity in COPD patients while targeting of TNF-alpha in the lung may prevent smokers progressing to COPD...
  48. ncbi Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity
    P K Jeffery
    Department of Lung Pathology, National Heart and Lung Institute, London, England, U K
    Am Rev Respir Dis 140:1745-53. 1989
    ..We have studied the light and electron microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy from 11 atopic asthmatics, four of whom were symptomatic and seven of whom were asymptomatic...
  49. doi Case records of the Massachusetts General Hospital. Case 10-2008. A 10-year-old girl with dyspnea on exertion
    Kenan E Haver
    Pediatric Pulmonary, Massachusetts General Hospital, USA
    N Engl J Med 358:1382-90. 2008
  50. pmc Transbronchial biopsy in usual interstitial pneumonia
    Ema A Berbescu
    David Geffen School of Medicine at UCLA, 37 131 Center for the Health Sciences, Los Angeles, CA 90095, USA
    Chest 129:1126-31. 2006
    ..Transbronchial biopsy (TBB) has been utilized only to exclude other diseases such as sarcoidosis, lymphangitic carcinoma, and infection, for example, but TBB is generally considered to have little role in confirming UIP...
  51. ncbi Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer
    Felix J F Herth
    Department of Pulmonary and Critical Care Medicine, Thoraxklinik, Heidelberg, Germany
    Chest 138:790-4. 2010
    ..We examined whether both procedures could be performed with a single endobronchial ultrasound bronchoscope...
  52. ncbi Airway stenting: Applications and practice management considerations
    Mark E Lund
    Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Rd, Boston, MA 02215, USA
    Chest 131:579-87. 2007
    ..is a procedure that is performed increasingly often, and the availability of metallic stents placed by flexible bronchoscopy may have contributed to the increased usage...
  53. ncbi Interventional bronchoscopy for treatment of tracheal obstruction secondary to benign or malignant thyroid disease
    Marc Noppen
    Interventional Endoscopy Clinic and Respiratory Division, Academic Hospital AZ VUB 101, Free University of Brussels, Laarbeeklaan V, 1000 Brussels, Belgium
    Chest 125:723-30. 2004
    ..The objective of this study is to evaluate the results of interventional bronchoscopic procedures in the treatment of severe tracheal obstruction due to thyroid disease...
  54. ncbi Rigid bronchoscopic intervention in patients with respiratory failure caused by malignant central airway obstruction
    Kyeongman Jeon
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Thorac Oncol 1:319-23. 2006
    ..In critically ill patients, however, the only studies of bronchoscopic intervention are relatively small series...
  55. ncbi Bronchoscopic features and bronchoscopic intervention for endobronchial hamartoma
    Su A Kim
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Respirology 15:150-4. 2010
    ..Bronchoscopic resection of endobronchial hamartomas has been reported to have a favourable outcome. This study describes the bronchoscopic features of endobronchial hamartoma and reports the clinical outcome of bronchoscopic intervention...
  56. ncbi Incidence of bacteraemia following endobronchial ultrasound-guided transbronchial needle aspiration
    D P Steinfort
    Dept of Respiratory Medicine, Level 1, Centre for Medical Research Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Eur Respir J 36:28-32. 2010
    ..The incidence of bacteraemia following EBUS-TBNA is comparable to that following routine flexible bronchoscopy. Performance of TBNA does not appear to measurably increase the risk of bacteraemia over that associated with ..
  57. ncbi Inhalation injury, pulmonary perturbations, and fluid resuscitation
    Frederick W Endorf
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Burn Care Res 28:80-3. 2007
    ..We identified 80 patients with suspected INHI that required intubation, mechanical ventilation, and fiber optic bronchoscopy in the first 24 hours of their admission...
  58. ncbi The value of fiberoptic bronchoscopy in culture-positive pulmonary tuberculosis patients whose pre-bronchoscopic sputum specimens were negative both for smear and PCR analyses
    Atsuhisa Tamura
    Department of Respiratory Diseases, National Hospital Organization Tokyo National Hospital, Kiyose
    Intern Med 49:95-102. 2010
    This study assessed the diagnostic rate of pulmonary tuberculosis (PTB) using fiberoptic bronchoscopy (FBS) in patients with suspected PTB, and negative pre-bronchoscopy smear and polymerase-chain reaction (PCR) in sputum.
  59. pmc Primary leiomyoma of the trachea, bronchus, and pulmonary parenchyma--a single-institutional experience
    Joon Suk Park
    Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Eur J Cardiothorac Surg 41:41-5. 2012
    ..Primary leiomyoma of the respiratory tract is a rare disease. Based on our experience, we investigated its clinical characteristics and outcomes of treatment...
  60. ncbi Treatment of advanced emphysema with emphysematous lung sealant (AeriSeal®)
    F J F Herth
    Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, Germany Felix Herth thoraxklinik heidelberg de
    Respiration 82:36-45. 2011
    ..This report summarizes initial tests of an emphysematous lung synthetic polymer sealant (ELS) designed to reduce lung volume in patients with advanced emphysema...
  61. ncbi A comparison of autofluorescence bronchoscopy and white light bronchoscopy in detection of lung cancer and preneoplastic lesions: a meta-analysis
    Weizhen Chen
    Department of Respiratory Diseases, General Hospital of People s Liberation Army, Beijing, China
    Lung Cancer 73:183-8. 2011
    It is known that autofluorescence bronchoscopy (AFB) has limited value in detection of lung cancer and preneoplastic lesions...
  62. pmc Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis
    Neal Navani
    Centre for Respiratory Research, University College London, London, UK
    Respirology 16:467-72. 2011
    ..The aim of this study was to evaluate the feasibility, safety and efficacy of combined EBUS-TBNA and standard bronchoscopic techniques in patients with suspected sarcoidosis and enlarged mediastinal or hilar lymphadenopathy...
  63. ncbi Minimally invasive bronchoscopic resection of benign tumors of the bronchi
    Ascedio Jose Rodrigues
    Respiratory Endoscopy Department, University of São Paulo School of Medicine Hospital das Clinicas, Sao Paulo, Brazil
    J Bras Pneumol 37:796-800. 2011
    Primary benign tumors of the trachea and main bronchi are uncommon. Interventional bronchoscopy allows the diagnosis and the treatment of some of these lesions.
  64. ncbi Utility of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal masses of unknown etiology
    Kazuhiro Yasufuku
    Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 91:831-6. 2011
    ..The purpose of the current study was to investigate the clinical utility of EBUS-TBNA in the diagnosis of mediastinal masses of unknown etiology...
  65. ncbi Bronchoscopic thermal vapour ablation therapy in the management of heterogeneous emphysema
    Gregory Snell
    Allergy Immunology and Respiratory Medicine, The Alfred Hospital, 55 Commercial Road, Melbourne, Victoria 3004, Australia
    Eur Respir J 39:1326-33. 2012
    ..BTVA therapy results in clinically relevant improvements in lung function, quality of life and exercise tolerance in upper lobe predominant emphysema...
  66. ncbi Fibreoptic bronchoscopy in the diagnosis of sputum smear-negative pulmonary tuberculosis: current status
    Alladi Mohan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
    Indian J Chest Dis Allied Sci 50:67-78. 2008
    ..Performing fibreoptic bronchoscopy (FOB), and subjecting the bronchoscopic secretions/transbronchial lung biopsy (TBLB) material to conventional ..
  67. ncbi American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients
    Momen M Wahidi
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 140:1342-50. 2011
    Optimal performance of bronchoscopy requires patient's comfort, physician's ease of execution, and minimal risk. There is currently a wide variation in the use of topical anesthesia, analgesia, and sedation during bronchoscopy.
  68. ncbi Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration: results of the AQuIRE Bronchoscopy Registry
    David E Ost
    Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Chest 140:1557-66. 2011
    ..Prospective data are needed to determine risk-adjusted diagnostic yield...
  69. ncbi Bronchoscopically obtained volatile biomarkers in lung cancer
    Kaid Darwiche
    Department of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Essen, Tuschener Weg 40, 45239, Essen, Germany
    Lung 189:445-52. 2011
    ..These VOCs can be detected with methods such as ion mobility spectrometry (IMS); their origin remains unknown...
  70. ncbi Macroscopic and histological findings in the healing process of inhalation injury
    Atsuhiro Arakawa
    Department of Reconstructive Plastic Surgery and Burn Center, Hamamatsu Medical Center, Hamamatsu, Japan
    Burns 33:855-9. 2007
    Although many investigators reported the diagnostic and therapeutic value of bronchoscopy in the early stage of inhalation injury, few findings in the late stage of inhalation injury have been reported...
  71. pmc Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study
    Amir Soltani
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, 17 Liverpool St, Hobart, 7000, Australia
    Respir Res 11:105. 2010
    ..We conducted an initial pilot study comparing BB from COPD patients with nonsmoking controls. This pilot study suggested the presence of reticular basement membrane (Rbm) fragmentation and altered vessel distribution in COPD...
  72. ncbi Endobronchial ultrasound for lung cancer staging: how many stations should be sampled?
    Mark I Block
    Thoracic Surgery, Memorial Healthcare System, Hollywood, Florida, USA
    Ann Thorac Surg 89:1582-7. 2010
    ..An experience with systematic sampling using EBUS to determine how many stations should be sampled to adequately detect mediastinal disease was evaluated...
  73. pmc Fiberoptic bronchoscopy for the rapid diagnosis of smear-negative pulmonary tuberculosis
    Jung Ar Shin
    Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju ro, Seoul 135 720, South Korea
    BMC Infect Dis 12:141. 2012
    This study was aimed to investigate the diagnostic value of fiberoptic bronchoscopy (FOB) with chest high-resolution computed tomography (HRCT) for the rapid diagnosis of active pulmonary tuberculosis (PTB) in patients suspected of PTB ..
  74. ncbi A proposed classification system of central airway stenosis
    L Freitag
    Lungenklinik Hemer, 58675 Hemer, Germany
    Eur Respir J 30:7-12. 2007
    ..Such a system will enhance the ability to study the effectiveness of treatment modalities for central airway stenosis...
  75. ncbi Impact of a Mycobacterium tuberculosis-specific interferon-γ release assay in bronchoalveolar lavage fluid for a rapid diagnosis of tuberculosis
    C Jafari
    Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
    J Intern Med 270:254-62. 2011
    ..Evaluation of different methods for an initial treatment decision in individuals with suspected pulmonary tuberculosis...
  76. ncbi Optical coherence tomography as an adjunct to flexible bronchoscopy in the diagnosis of lung cancer: a pilot study
    Ross G Michel
    Division of Pulmonary Critical Care Medicine, Oklahoma City Veterans Affairs Medical Center and University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 5020, USA
    Chest 138:984-8. 2010
    ..The objectives of this study were to determine the feasibility of using OCT imaging during flexible bronchoscopy and to preliminarily assess the ability of OCT imaging to distinguish an endobronchial malignancy from normal ..
  77. ncbi Bronchoscopic findings in children with chronic wet cough
    Daniela Zgherea
    Department of Pediatrics, Maimonides Infants and Children s Hospital of Brooklyn, Brooklyn, NY, USA
    Pediatrics 129:e364-9. 2012
    ..The objective of this study was to determine the frequency of bacterial bronchitis in children with chronic wet cough and to analyze their bronchoscopic findings...
  78. ncbi Fiberoptic bronchoscopy-assisted percutaneous tracheostomy is safe in obese critically ill patients: a prospective and comparative study
    Carlos M Romero
    Critical Care Unit, University of Chile Clinical Hospital, Santiago Norte, Chile
    J Crit Care 24:494-500. 2009
    ..In Latin America, 10% to 35% of the population is obese. Obese critically ill patients are at greater risk for requiring intubation and prolonged mechanical ventilation; and in some cases, it is necessary to perform a tracheostomy...
  79. ncbi Electromagnetic navigation diagnostic bronchoscopy for small peripheral lung lesions
    D Makris
    Clinic of Respiratory Disease, Department of Anatomopathology, Albert Calmette Hospital, Centre Hospitalier Régional University of Lille, 59037 Lille, France
    Eur Respir J 29:1187-92. 2007
    The present study prospectively evaluated the diagnostic yield and safety of electromagnetic navigation-guided bronchoscopy biopsy, for small peripheral lung lesions in patients where standard techniques were nondiagnostic...
  80. ncbi Cluster of pseudoinfections with Burkholderia cepacia associated with a contaminated washer-disinfector in a bronchoscopy unit
    Dror Rosengarten
    Institute of Pulmonology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Infect Control Hosp Epidemiol 31:769-71. 2010
    ..cepacia complex. The cause of this pseudo-outbreak was that the washer-disinfector was installed without the required antibacterial filter...
  81. pmc Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers
    J M Löfdahl
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Clin Exp Immunol 145:428-37. 2006
    ..Some alterations were found in smokers compared to non-smokers, thus indicating that changes in AM phenotype may be associated with smoking per se. The functional relevance of our findings remains to be elucidated...
  82. pmc Advances in diagnostic bronchoscopy
    Andrew R Haas
    Clinical Operations, Interventional Pulmonology and Thoracic Oncology, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Respir Crit Care Med 182:589-97. 2010
    Diagnostic bronchoscopy has undergone two major paradigm shifts in the last 40 years...
  83. ncbi Tracheobronchial foreign bodies in children: importance of accurate history and plain chest radiography in delayed presentation
    B Tokar
    Departments of Paediatric Surgery and Radiology, Osmangazi University Faculty of Medicine, Eskisehir, Turkey
    Clin Radiol 59:609-15. 2004
    ..To evaluate the factors associated with delayed diagnosis of foreign body aspiration (FBA) in children and to compare clinical, radiological and bronchoscopic findings in the patients with suspected FBA...
  84. ncbi Mediastinoscopy: still the gold standard
    Joseph B Shrager
    Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    Ann Thorac Surg 89:S2084-9. 2010
    ..There are scenarios in which EBUS is preferable to mediastinoscopy. However, for routine staging of the upper mediastinum in non-small cell lung cancer, the benefits of EBUS over mediastinoscopy remain unproven...
  85. ncbi Endoscopic ultrasound-guided fine needle aspiration in the evaluation of suspected lung cancer
    T L Ang
    Division of Gastroenterology, Changi General Hospital, 2 Simei St 3, Singapore 529889, Singapore
    Respir Med 101:1299-304. 2007
    ..This prospective study aimed to define the effectiveness of EUS-FNA as an adjunct to computer tomography (CT) and bronchoscopy in the evaluation of suspected lung cancer in routine clinical practice.
  86. ncbi Natural stent in the management of post-intubation tracheal stenosis
    Hye Yun Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Respirology 14:583-8. 2009
    ..A new silicone stent, called the Natural stent (N stent), was investigated for its clinical efficacy and safety in patients with PITS...
  87. ncbi Diagnostic results before and after introduction of autofluorescence bronchoscopy in patients suspected of having lung cancer detected by sputum cytology in lung cancer mass screening
    M Sato
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Lung Cancer 32:247-53. 2001
    ..To clarify the role of autofluorescence bronchoscopy in localizing tumors in patients with roentgenographically occult cancer, we analyzed our diagnostic results...
  88. ncbi Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Department of Respiratory Medicine, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:453-60. 2005
    ..47; p = 0.03). Endobronchial valve placement can improve lung volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolong exercise time by reducing dynamic hyperinflation...
  89. ncbi Electromagnetic navigation bronchoscopy (ENB): Increasing diagnostic yield
    B Lamprecht
    Department of Pulmonary Medicine, Paracelsus Medical University Hospital, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Respir Med 106:710-5. 2012
    ..To determine factors associated with diagnostic yield of ENB...
  90. ncbi Outcomes of airway stenting for advanced lung cancer with central airway obstruction
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Interact Cardiovasc Thorac Surg 11:425-8. 2010
    ..Interventional therapeutic bronchoscopy including airway stenting (AS) providing immediate and effective palliation is therefore essential to improve ..
  91. ncbi Bronchial anthracofibrosis and tuberculosis in immigrants to Canada from the Indian subcontinent
    J Hwang
    Department of Pathology, University of Alberta, Edmonton, Alberta, Canada
    Int J Tuberc Lung Dis 14:231-7. 2010
    ..It is a bronchoscopic finding that is not uncommonly associated with pulmonary tuberculosis (PTB) in residents of South Korea, Iran and India. It is largely unrecognized in the Western world...
  92. ncbi Benign fibroepithelial polyp arising in the bronchus: a case report and review of the literature
    Parth B Amin
    Department of Surgery, Wayne State University and Detroit Medical Center, Detroit, Michigan, USA
    Arch Surg 144:1081-3. 2009
    ..We describe a man with repeated visits to emergency departments for coughing spells who ultimately underwent bronchoscopy and biopsy...
  93. ncbi Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma
    W J Elston
    Dept of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX, UK
    Eur Respir J 24:375-7. 2004
    b>Bronchoscopy with endobronchial biopsy (EBB) and/or bronchoalveolar lavage (BAL) has become an important research tool in asthma. A recent report has suggested audit and reporting of the safety of these procedures...
  94. ncbi Endobronchial ultrasound-guided transbronchial fine-needle aspiration: the University of Minnesota experience, with emphasis on usefulness, adequacy assessment, and diagnostic difficulties
    Mariam Alsharif
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Clin Pathol 130:434-43. 2008
    ..For pathologists, this was a relatively time-consuming procedure. Recognizing bronchial contamination, especially with metaplastic or dysplastic cells, is important for avoiding diagnostic pitfalls...
  95. ncbi Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    P Bhavsar
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 63:784-90. 2008
    ....
  96. ncbi Impact of rapid on-site cytologic evaluation during transbronchial needle aspiration
    Daniel Baram
    Division of Pulmonary Critical Care, Stony Brook University, T 17, 040 HSC, Stony Brook, NY 11794 8172, USA
    Chest 128:869-75. 2005
    To determine the extent to which rapid on-site cytologic evaluation (ROSE) of transbronchial needle aspiration (TBNA) samples can safely and cost-effectively reduce the need for additional biopsy during bronchoscopy.
  97. ncbi Human in vivo fluorescence microimaging of the alveolar ducts and sacs during bronchoscopy
    L Thiberville
    Clinique Pneumologique, Hopital Charles Nicolle, CHU de Rouen, Rouen Cedex, France
    Eur Respir J 33:974-85. 2009
    ..confocal fluorescence microscopy (FCFM) as a tool for imaging the alveolar respiratory system in vivo during bronchoscopy. A 488-nm excitation wavelength FCFM device was used in 41 healthy subjects including 17 active smokers...
  98. ncbi Bronchoscopy for the diagnosis and staging of lung cancer
    Ezzat El-Bayoumi
    Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Respir Crit Care Med 29:261-70. 2008
    b>Bronchoscopy is an invaluable tool utilized for the diagnosis, staging, and management of lung cancer...
  99. ncbi Efficacy of endobronchial ultrasound-guided transbronchial needle aspiration of hilar lymph nodes for diagnosing and staging cancer
    Armin Ernst
    Department of Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Thorac Oncol 4:947-50. 2009
    ..We sought to determine the efficacy of EBUS-TBNA in sampling enlarged hilar lymph nodes in this patient population...
  100. ncbi Diagnostic yield of bronchoscopy with bronchoalveolar lavage in febrile patients with hematologic malignancies and pulmonary infiltrates
    Margit Hummel
    3 Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Ann Hematol 87:291-7. 2008
    ..The diagnostic value of fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) in these patients is controversial...
  101. ncbi MDCT of the central airways: comparison with bronchoscopy in the evaluation of complications of endotracheal and tracheostomy tubes
    Maryellen Sun
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Imaging 22:136-42. 2007
    To evaluate the accuracy of multidetector row computed tomography (MDCT) compared with bronchoscopy in the assessment of airway complications related to endotracheal and tracheostomy tubes.

Research Grants63

  1. Validation of a multi-gene test for lung cancer risk
    James C Willey; Fiscal Year: 2010
    ..of 14 key antioxidant, DNA repair and transcription factor genes measured in NBEC sampled at the time of bronchoscopy. The test was discovered in a case control study comprising 49 subjects (25 cancer and 24 controls) and ..
  2. Expression signatures of TB-specific memory responses within the human lung
    Richard F Silver; Fiscal Year: 2013
    ..Our research team represents a unique collaboration of investigators with experience in bronchoscopy-based studies of human immunity to Mtb (Richard Silver, Case Western Reserve University) assessment of immune ..
  3. Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
    Ann E Tilley; Fiscal Year: 2013
    ..We will use bronchoscopy to obtain airway epithelial cells and will study gene expression in those cells both ex vivo and after culture ..
  4. The Role of CD8 T Cells in Chronic Granulomatous Inflammation
    Kyra A Oswald-Richter; Fiscal Year: 2013
    ..of mycobacterial proteins in both CD4+ and CD8+ T cells derived from sarcoidosis subjects at diagnostic bronchoscopy. The unexpected finding of antigen-specific CD8+ T cells suggested that CD8+ T cells may play an important role ..
  5. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2010
    ..A total of 200 enrolled subjects will provide oropharyngeal washing (OPW, gargle) specimens and will undergo bronchoscopy with bronchoalveolar lavage (BAL) for the diagnosis of PCP and TB...
  6. The role of Vitamin D metabolism in Non-Small Cell Lung Cancer
    Nithya Ramnath; Fiscal Year: 2012
    ..study the expression of CYP24A1 in both lung tumor and unaffected respiratory epithelium in patients undergoing bronchoscopy for diagnosis of late stage lung cancer...
  7. Imaging Inflammation in Asthma
    Serpil C Erzurum; Fiscal Year: 2010
    ..is not routine, and evaluation of regional airway inflammation is not currently possible except by invasive bronchoscopy. Our goal in this study is to develop a noninvasive imaging method based on chemical activities of metabolites ..
  8. PPAR?? and Alveolar Macrophage Phenotype in Acute Lung Injury
    Annette M Esper; Fiscal Year: 2013
    ..Eligible subjects will undergo bronchoscopy with bronchoalveolar lavage to isolate AMs and perform assays measuring PPARg activity, markers of AM ..
  9. HIV and COPD:Immune mediated mechanisms
    Benjamin D Medoff; Fiscal Year: 2013
    ..chronic HIV, we propose to extensively phenotype HIV infected subjects using cutting-edge imaging technologies, bronchoscopy, and advanced immune assays, and correlate these measures to the incidence and progression of COPD...
  10. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip M Boiselle; Fiscal Year: 2012
    ..noninvasive method for diagnosing tracheomalacia, with comparable accuracy to the current gold standard of bronchoscopy, an invasive procedure...
  11. Improving Colonoscopy Quality through Automated Monitoring
    Piet C de Groen; Fiscal Year: 2010
    ..to other endoscopic medical procedures such as upper gastrointestinal endoscopy, cystoscopy, arthroscopy and bronchoscopy. Our long-term objective is to ensure that all endoscopic examinations of the colon, so called colonoscopies, ..
  12. Doxycycline for COPD in HIV-Infected Patients
    Robert J Kaner; Fiscal Year: 2013
    ..will include change in FEV1, reduction of MMP activity in epithelial lining fluid and cells obtained by bronchoscopy and doxycycline levels in blood, ELF and BAL cell pellets...
  13. Kit Inhibition in Asthma (KIA)
    Elliot Israel; Fiscal Year: 2012
    ..In concert with our collaborating centers-through physiologic assessments, bronchoscopy with endobronchial biopsy/BAL, and multidetector CT imaging--we will characterize imatinib's effect on ..
  14. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..test this hypothesis, we will recruit subjects with mild and severe asthma and normal controls who will undergo bronchoscopy with proximal (endobronchial) and distal (transbronchial) lung biopsy...
  15. Multi-lumen steerable needles for transoral access to lung nodules
    Ron Alterovitz; Fiscal Year: 2013
    ..spans the areas of expertise necessary to accomplish these aims, including expertise in cardiothoracic surgery, bronchoscopy, radiology, mechanical engineering, and computer science...
  16. Multimodal Image-Guided Intervention System for Lung-Cancer Diagnosis and Staging
    WILLIAM EVAN HIGGINS; Fiscal Year: 2013
    ..project is to construct a multimodal image-guided intervention (IGI) system for the planning and guidance of bronchoscopy. The system will have the following features: 1) be easy to use, independent of physician skill and experience;..
  17. High-specificity, non-invasive methods for monitoring lung transplants
    JOHN FREDERIC BEAUSANG; Fiscal Year: 2013
    ..discriminating infection versus rejection requires a complex and expensive battery of tests including invasive bronchoscopy with biopsy to ensure that the appropriate treatment is given...
  18. T cell response in scleroderma lung disease: from pathogenesis to clinical care
    Francesco Boin; Fiscal Year: 2012
    ..T cell polarization will be measured in the blood and BAL fluid of the cohort patients (Aim1) undergoing bronchoscopy for suspected active ILD and correlated with the subsequent course of lung disease and outcome...
  19. Effects of Traffic Pollution on Lung Immunity and Pneumonia in Persons with HIV
    Robert J Blount; Fiscal Year: 2013
    ..We will obtain alveolar macrophages from each participant using bronchoscopy with bronchoalveolar lavage (BAL) (Specific Aim 2)...
  20. Longitudinal Phenomics and Genetics of Severe Asthma
    Deborah A Meyers; Fiscal Year: 2013
    ..In a substudy, investigative bronchoscopy will be performed at baseline and year 3...
  21. Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIV
    Alison Morris; Fiscal Year: 2013
    ..We will perform oral wash, sputum induction, bronchoscopy, and blood draws in HIV- and HIV-I- subjects and carry out high-throughput virus metagenomics and bacterial, ..
  22. Th2 inflammation promotes airway surface liquid dehydration
    MICHAEL M MYERBURG; Fiscal Year: 2013
    ..Tissue samples will be collected by bronchoscopy and used to correlate NHE3 and pendrin expression with markers of Th2 inflammation and with rates of airway ..
  23. A non-invasive gene-expression biomarker of airway response to tobacco exposure
    AVRUM E SPIRA; Fiscal Year: 2010
    ..airway-wide epithelial cell "field of injury" and that gene expression, in airway epithelial cells obtained at bronchoscopy, reflects host response to smoking...
  24. Mechanisms of Familial Pulmonary Fibrosis
    Timothy S Blackwell; Fiscal Year: 2013
    ..At risk individuals (with and without radiographic abnormalities) will undergo bronchoscopy to identify phenotypic characteristics of alveolar epithelial cells, such as ER stress, herpesvirus infection, ..
  25. Surfactant protein D as Modulator of Lung Inflammation and COPD Pathogenesis
    MICHAEL WILLIAM SIMS; Fiscal Year: 2012
    ..All subjects will undergo bronchoscopy for collection of bronchoalveolar lavage specimens...
  26. Early Functional Genetic and Epigenetic Changes in Human Lung Carcinogenesis
    Simon D Spivack; Fiscal Year: 2010
    ..The key concordant marks for both expression and epigenetic features will be reconfirmed in fluorescent bronchoscopy-guided brush-exfoliated bronchial cells of normal, dysplastic, and malignant epithelium from a subset of donors...
  27. Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol in Mild Asthma
    Nicola A Hanania; Fiscal Year: 2013
    ..A substudy (n = 30) will employ bronchoscopy in a subset of subjects to investigate the effects of nadolol on airway inflammation and mucous metaplasia ..
  28. Role of Th2 and non-Th2 Inflammation in Airway Smooth Muscle Remodeling in Asthma
    Prescott G Woodruff; Fiscal Year: 2012
    ..These studies will be performed in vivo by applying bronchoscopy, design-based stereology, laser capture microdissection and genomics in a detailed study of asthmatics and ..
  29. Mucus and hypoxia in heterogeneous and progressive CF lung disease
    Stephen Stick; Fiscal Year: 2013
    ..in a unique CF cohort identified by newborn screening and studied at regular intervals with CT scans and bronchoscopy. Using samples obtained in the successful Australian AREST-CF program, we will develop a triad of novel ..
  30. Lung Transplant Microbiome and Chronic Allograft Dysfunction
    Ronald G Collman; Fiscal Year: 2013
    ..sequencing &analytic approaches to define microbial populations in the lower respiratory tract (LRT) by bronchoscopy, including methods to account for challenges in LRT analysis such as upper respiratory tract carryover &..
  31. Ultrafast Tomosynthesis for Transbronchial Biopsy Guidance
    Rebecca Fahrig; Fiscal Year: 2011
    ..One safe, dose reducing and time-saving technique to guide TBNbx is electromagnetic navigation bronchoscopy (ENB), which guides biopsy tools to predetermined locations within the bronchial tree using manual registration ..
  32. Tissue and Airway Analysis for Emphysema Interventions
    Juerg Tschirren; Fiscal Year: 2012
    ..for high throughput sites: The original software was designed to handle a typical clinical load in a pulmonary bronchoscopy suite that would typically be at most 3-4 cases per day...
  33. Increasing the diagnostic yield of low-risk bronchial biopsy in the evaluation of
    Melissa J Suter; Fiscal Year: 2013
    ..Macroscopic imaging modalities including CT and bronchoscopy have made significant strides in increasing early detection;however they do not have the required specificity ..
  34. Optical Nanoscale Analysis of Buccal Cells: Transforming Lung Cancer Screening
    Hemant K Roy; Fiscal Year: 2013
    ..of screening for lung cancer allowing rational use of more expensive or intrusive tools such as CT scans or bronchoscopy. This novel paradigm could transform the clinical practice of lung cancer screening and thereby mitigate the ..
  35. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..tuberculosis (TB) and bacterial pneumonia are common, other processes may cause pneumonia in these patients, so bronchoscopy with bronchoalveolar lavage (BAL) is often indicated for definitive diagnosis, especially when empiric ..
  36. MicroFlex Technology for Early Detection of Lung Disease
    DALE A LAWRENCE; Fiscal Year: 2013
    ..will provide unprecedented flexibility and controllability for bronchoscopes, enabling minimally invasive bronchoscopy to reach previously inaccessible peripheral bronchi and provide direct visualization and tool manipulation ..
  37. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2002
    ..goblet cell degranulation, and goblet cell expression of mucin genes in endobronchial biopsies obtained during bronchoscopy from healthy and asthmatic subjects...
  38. Synergistic CT-Bronchoscopy for Lung-Cancer Assessment
    William Higgins; Fiscal Year: 2007
    ..It is driven by the following hypothesis: A synergistic combination of 3D MDCT imaging, image processing, and bronchoscopy improves current procedures for the staging, diagnosis, and treatment of lung cancer...
  39. Biodegradable Sealant for Biopsy Tracts in Soft Tissues
    LUCJAN HRONOWSKI; Fiscal Year: 2003
    ..Using imaging guidance (CT, fluoroscopy, ultrasound or bronchoscopy) a sharp needle is advanced into a suspicious area and cells are aspirated into the needle...
  40. Biodegradable Sealant for Biopsy Tract in Soft Tissue
    LUCJAN HRONOWSKI; Fiscal Year: 2006
    ..Using imaging guidance {CT, fluoroscopy, ultrasound or bronchoscopy) a sharp needle is advanced into a suspicious area and cells are aspirated into the needle...
  41. Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
    ERIK LANGE; Fiscal Year: 2006
    ..b>Bronchoscopy is used to locate anomalies in a patient's bronchus and if necessary, take a biopsy...
  42. IL-1 AND B-ADRENERGIC SYSTEM OF HUMAN AIRWAY EPITHELIUM
    Steven Kelsen; Fiscal Year: 1999
    ..Aim 2 will be performed on airway epithelial cells harvested at bronchoscopy by bronchial brushing...
  43. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ..for sequencing, genotyping and haplotyping candidate genes, and determination of levels of gene expression in bronchoscopy samples; 2) identified in the Department of Public Health Sciences (PHS) to a) assist in the analysis of data ..
  44. MULTIDAY EXPOSURE TO O3 IN ASTHMA
    John Balmes; Fiscal Year: 2002
    ..respiratory tract inflammation in healthy and asthmatic subjects has been generated from studies involving bronchoscopy and analysis of bronchoalveolar lavage (BAL) fluid...
  45. SUBCLINICAL CMV INFECTION AFTER MARROW TRANSPLANTATION
    William Nichols; Fiscal Year: 2004
    ..of the interaction between CMV infection and invasive pulmonary aspergillosis (IPA) will be evaluated; routine bronchoscopy will be performed on all patients, and the pulmonary CMV load will be correlated with the incidence of ..
  46. Use of CO2 Lasers for Treatment of Airway Obstruction
    ROKAN AHMAD; Fiscal Year: 2005
    ..The ND: YAG laser is the current laser of choice for laser bronchoscopy. Its deep tissue penetration (up to 10 mm) is beneficial for coagulation but presents significant risk of ..
  47. TUBERCULOSIS AND AIDS
    John Conte; Fiscal Year: 1999
    ..By performing bronchoscopy and bronchoalveolar lavage (BAL) in patients with pulmonary tuberculosis and measuring drug levels using highly ..
  48. MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMA
    Prescott Woodruff; Fiscal Year: 2006
    ..Application of these techniques to bronchial biopsy specimens obtained during bronchoscopy will make possible, for the first time, the study of gene expression in airway smooth muscle cells isolated ..
  49. THE ROLE OF ALPHA-DEFENSINS IN CYSTIC FIBROSIS LUNG DISE
    L Spencer; Fiscal Year: 2004
    ..The methodology of this project is diverse, consisting of patient selection and recruitment, research bronchoscopy and specimen processing, complimentary ex vivo assays and experiments, collection of clinical data, clinical ..
  50. Mentored Patient-Oriented Research Career Development Aw
    ALISSA GREENBERG; Fiscal Year: 2004
    ..They will recruit cigarette smokers and perform bronchoscopy with endobronchial biopsies pre- and post-treatment with GC...
  51. Computer Assisted Ultrathin Brochoscopy
    David Naidich; Fiscal Year: 2006
    ..for Development of Imaging Systems Application is to develop novel approaches for computer assisted ultrathin bronchoscopy (CAUB) for biopsying small peripheral lung nodules...
  52. Lung Cancer Diagnostic Test Validation in FNA Specimens
    James Willey; Fiscal Year: 2004
    ..However the small cytology specimens obtained by FNA or bronchoscopy are not sufficient for most gene expression assay methods...
  53. Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
    Timothy Riehle; Fiscal Year: 2009
    ..b>Bronchoscopy is used to locate anomalies in a patient's bronchus and if necessary, take a biopsy...
  54. Candidate Genes for Susceptibility to Bronchitis
    Ronald Crystal; Fiscal Year: 2007
    ..Using fiberoptic bronchoscopy with airway epithelial brushing to obtain pure populations of airway epithelium, preliminary mRNA expression ..
  55. Raman Probe for Bronchial Premalignant Lesions
    Stephen Fulghum; Fiscal Year: 2006
    ..world, and has a very low (14%) five year survival rate, an instrument that can be easily utilized with normal bronchoscopy procedures will add clinical medical value by enabling real time examination of suspicious sights, with ..
  56. CatheterScope for Intraluminal Image of Early.Neoplasia
    Eric Seibel; Fiscal Year: 2006
    ..The long-term goals are to bring laser scanning endoscopy and bronchoscopy to the forefront of minimally-invasive medical practice, as a tool to image remote locations in the body, ..
  57. CatheterScope for Intraluminal Image of Early.Neoplasia
    Eric Seibel; Fiscal Year: 2003
    ..The long-term goals are to bring laser scanning endoscopy and bronchoscopy to the forefront of minimally-invasive medical practice, as a tool to image remote locations in the body, ..
  58. Multimodality virtual endoscopy with hybrid PET/CT units
    Luc Bidaut; Fiscal Year: 2007
    ..optical fiber (the endoscope) is used for visually inspecting the inner lining of organs such as the airways (bronchoscopy) or the colon (colonoscopy)...
  59. EARLY DETECTION OF RADIATION-INDUCED PULMONARY TOXICITY
    SANDRA MC DONALD; Fiscal Year: 1993
    ..Because HDR brachytherapy requires bronchoscopy, it provides a unique opportunity, via bronchoalveolar lavage (BAL), to study the effects of irradiation in ..
  60. SURVEILLANCE AND CHEMOPREVENTION FOR SECOND LUNG CANCERS
    Jenny Mao; Fiscal Year: 2001
    ..the feasibility and impact of combined sputum analysis (cytology and immunostaining), fluorescence (LIFE) bronchoscopy and spiral CT as surveillance strategies for SPLC and/or recurrence after curative surgical treatment, 2) to ..
  61. LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS
    Jenny Mao; Fiscal Year: 2007
    ..All subjects will be followed with serial tests including sputum analysis, LIFE bronchoscopy and spiral CT according to a pre- determined algorithm...
  62. Micro-Flex Technology for Early Detection of Lung Cancer
    DALE LAWRENCE; Fiscal Year: 2005
    ..New, cost-effective techniques are needed to screen, localize, sample, and treat suspicious lesions. Bronchoscopy is a proven method of visualizing the airways of the lung and performing biopsies of suspicious tissue...
  63. Epithelial Dysfunction in Early IPF
    TIMOTHY BLACKWELL; Fiscal Year: 2009
    ..subjects with early FIP identified by screening with high resolution computed tomography scanning will undergo bronchoscopy for sample collection to test the following hypothesis...