bronchoscopy

Summary

Summary: Endoscopic examination, therapy or surgery of the bronchi.

Top Publications

  1. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
  2. doi Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer
    Felix J F Herth
    Department of Pulmonary and Critical Care Medicine, Thoraxklinik, Heidelberg, Germany
    Chest 138:790-4. 2010
  3. doi Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer
    Bin Hwangbo
    Center for Lung Cancer, National Cancer Center, Goyang, Korea
    Chest 138:795-802. 2010
  4. doi Treatment of advanced emphysema with emphysematous lung sealant (AeriSeal®)
    F J F Herth
    Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, Germany Felix Herth thoraxklinik heidelberg de
    Respiration 82:36-45. 2011
  5. doi Confocal fluorescence endomicroscopy of the human airways
    Luc Thiberville
    Rouen University Hospital, CHU de Rouen, 1 rue de Germont, 76031 Rouen Cedex, France
    Proc Am Thorac Soc 6:444-9. 2009
  6. doi Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station?
    Hee Seok Lee
    Center for Lung Cancer, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang, Gyeonggi, 411 764, Korea
    Chest 134:368-74. 2008
  7. ncbi Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    M Patricia Rivera
    University of North Carolina at Chapel Hill, 4133 Bioinformatics Building, CB No 7020, Chapel Hill, NC 27599, USA
    Chest 132:131S-148S. 2007
  8. doi Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis
    K Adams
    Academic Division of Thoracic Surgery, Imperial College, Royal Brompton Hospital, London SW3 6NP, UK
    Thorax 64:757-62. 2009
  9. ncbi The safety of bronchoscopy in a pulmonary fellowship program
    Daniel R Ouellette
    Pulmonary and Critical Care Medicine, Henry Ford Hospital, 2799 West Grand Ave, Detroit, MI 48202, USA
    Chest 130:1185-90. 2006
  10. ncbi Airway stenting: Applications and practice management considerations
    Mark E Lund
    Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Rd, Boston, MA 02215, USA
    Chest 131:579-87. 2007

Detail Information

Publications312 found, 100 shown here

  1. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..Our study showed a close link between smoking and expression of TGF-beta1 in small airways. Our results also suggested that small airway epithelial cells might be involved in obstructive changes found in smokers and patients with COPD...
  2. doi Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer
    Felix J F Herth
    Department of Pulmonary and Critical Care Medicine, Thoraxklinik, Heidelberg, Germany
    Chest 138:790-4. 2010
    ..We examined whether both procedures could be performed with a single endobronchial ultrasound bronchoscope...
  3. doi Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer
    Bin Hwangbo
    Center for Lung Cancer, National Cancer Center, Goyang, Korea
    Chest 138:795-802. 2010
    ....
  4. doi Treatment of advanced emphysema with emphysematous lung sealant (AeriSeal®)
    F J F Herth
    Thoraxklinik am Universitatsklinikum Heidelberg, Heidelberg, Germany Felix Herth thoraxklinik heidelberg de
    Respiration 82:36-45. 2011
    ..This report summarizes initial tests of an emphysematous lung synthetic polymer sealant (ELS) designed to reduce lung volume in patients with advanced emphysema...
  5. doi Confocal fluorescence endomicroscopy of the human airways
    Luc Thiberville
    Rouen University Hospital, CHU de Rouen, 1 rue de Germont, 76031 Rouen Cedex, France
    Proc Am Thorac Soc 6:444-9. 2009
    ..This article reviews the capabilities and possible limitations of confocal microendoscopy for in vivo proximal and distal lung explorations...
  6. doi Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station?
    Hee Seok Lee
    Center for Lung Cancer, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang, Gyeonggi, 411 764, Korea
    Chest 134:368-74. 2008
    ....
  7. ncbi Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    M Patricia Rivera
    University of North Carolina at Chapel Hill, 4133 Bioinformatics Building, CB No 7020, Chapel Hill, NC 27599, USA
    Chest 132:131S-148S. 2007
    ....
  8. doi Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis
    K Adams
    Academic Division of Thoracic Surgery, Imperial College, Royal Brompton Hospital, London SW3 6NP, UK
    Thorax 64:757-62. 2009
    ..A systematic review was performed of published studies evaluating EBUS-TBNA for mediastinal lymph node staging to ascertain the pooled sensitivity and specificity of this investigation...
  9. ncbi The safety of bronchoscopy in a pulmonary fellowship program
    Daniel R Ouellette
    Pulmonary and Critical Care Medicine, Henry Ford Hospital, 2799 West Grand Ave, Detroit, MI 48202, USA
    Chest 130:1185-90. 2006
    To determine the complication rate from supervised training bronchoscopy in a single pulmonary fellowship program, and to examine the effects of fellow and faculty experience on this complication rate.
  10. ncbi Airway stenting: Applications and practice management considerations
    Mark E Lund
    Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Rd, Boston, MA 02215, USA
    Chest 131:579-87. 2007
    ..is a procedure that is performed increasingly often, and the availability of metallic stents placed by flexible bronchoscopy may have contributed to the increased usage...
  11. doi Bronchial anthracofibrosis: an emerging pulmonary disease due to biomass fuel exposure
    A Gupta
    Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Int J Tuberc Lung Dis 15:602-12. 2011
    ....
  12. doi Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions
    Takahiro Nakajima
    Departments of Thoracic Surgery and daggerDiagnostic Pathology, Graduate School of Medicine, Chiba University, Japan
    J Thorac Oncol 3:985-8. 2008
    The diagnosis of centrally located intrapulmonary tumors not visible on bronchoscopy may be a challenge...
  13. pmc Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study
    Neal Navani
    Center for Respiratory Research, University College London, London
    J Thorac Oncol 6:1505-9. 2011
    ..The utility of EBUS-TBNA in patients with extrathoracic malignancy was evaluated...
  14. doi Narrow-band imaging bronchoscopy increases the specificity of bronchoscopic early lung cancer detection
    Felix J F Herth
    Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany thoraxklinik heidelberg de
    J Thorac Oncol 4:1060-5. 2009
    ..New bronchoscopic technologies, including white light videobronchoscopy (WLB), autofluorescence imaging (AFI), and narrow band imaging (NBI), are aiming to diagnose airway neoplasia at a preinvasive stage...
  15. doi Bronchoscopic lung-volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham-controlled, multicentre trial
    P L Shah
    National Institute for Health Research Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust, Imperial College, London, UK
    Lancet 378:997-1005. 2011
    ..The aim of the EASE (Exhale airway stents for emphysema) trial was to evaluate safety and efficacy of airway bypass in people with severe homogeneous emphysema...
  16. ncbi Aetiology and presentation of HIV/AIDS-associated pulmonary infections in patients presenting for bronchoscopy at a referral hospital in northern Tanzania
    G S Kibiki
    Department of Internal Medicine, Endoscopy Unit, KCMC, Tumaini University, P O Box 3010, Moshi, Tanzania
    East Afr Med J 84:420-8. 2007
    ..To determine the aetiological agents of pulmonary infections in HIV-infected Tanzanians and to correlate the causative agents with clinical, radiographic features, and mortality...
  17. doi Lung volume reduction by bronchoscopic administration of steam
    Michael J Emery
    Veterans Affairs Puget Sound Health Care System and Seattle Institute for Biomedical and Clinical Research, Seattle, Washington, USA
    Am J Respir Crit Care Med 182:1282-91. 2010
    ..However, LVR by these methods is limited by temporary or incomplete collapse and/or residual atelectatic and scarred tissue volumes. Heat-induced ablation of lung tissue is currently under investigation as an alternative LVR methodology...
  18. ncbi Asthma control during the year after bronchial thermoplasty
    Gerard Cox
    St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    N Engl J Med 356:1327-37. 2007
    ..Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma...
  19. ncbi Clinical application of airway bypass with paclitaxel-eluting stents: early results
    Paulo F G Cardoso
    Department of Surgery, Division of Thoracic Surgery, Santa Casa de Porto Alegre Pavilhao Pereira Filho Hospital, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre RS, Brazil
    J Thorac Cardiovasc Surg 134:974-81. 2007
    ..To assess the safety and early clinical results of a multicenter evaluation of airway bypass with paclitaxel-eluting stents for selected patients with severe emphysema...
  20. doi Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer
    Jeong Eun Lee
    Department of Internal Medicine, Cancer Research Institute, Chungnam National University, 33 Munhwa ro, Gung gu, Daejeon, 301 721, Republic of Korea
    Lung Cancer 70:51-6. 2010
    ..We performed this study to evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the pathologic diagnosis of lung cancer including lung masses as well as lymph nodes as targets...
  21. ncbi Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
    S E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 156:737-43. 1997
    ..These findings suggest that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids which may be due to the severity of disease, glucocorticoid treatment, or other as yet undefined factors...
  22. doi A feasibility and safety study of bronchoscopic thermal vapor ablation: a novel emphysema therapy
    Gregory I Snell
    Alfred Hospital and Monash University, Melbourne, NSW 3004, Australia
    Ann Thorac Surg 88:1993-8. 2009
    ..This study reports the feasibility and safety of novel second-generation bronchoscopic lung volume reduction (LVR) technology, independent of collateral ventilation...
  23. ncbi Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Chest 126:122-8. 2004
    ....
  24. ncbi Epithelial damage and angiogenesis in the airways of children with asthma
    Angelo Barbato
    Divisione di Pneumologia, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari Università degli Studi di Padova, Via Giustiniani 3, Padova, Italy
    Am J Respir Crit Care Med 174:975-81. 2006
    ..Airway remodeling and inflammation are characteristic features of adult asthma that are still poorly investigated in childhood asthma...
  25. ncbi The effect of clonidine premedication on hemodynamic responses to microlaryngoscopy and rigid bronchoscopy
    I Matot
    Department of Anesthesia and Critical Care Medicine, Hadassah University School of Medicine, Jerusalem, Israel
    Anesth Analg 91:828-33. 2000
    The usual hemodynamic response to laryngoscopy and bronchoscopy is an increase in heart rate and arterial blood pressure. Previous work has reported that 10%-18% of the patients develop ischemic ST segment changes during the procedure...
  26. pmc Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study
    Claudia Jafari
    Clinical Infectious Diseases, Research Center Borstel, Borstel Germany
    Am J Respir Crit Care Med 180:666-73. 2009
    ..The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears...
  27. pmc Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Australia
    Clin Exp Immunol 150:22-9. 2007
    ..Systemic therapeutic targeting of TNF-alpha production by CD8(+) T cells may improve morbidity in COPD patients while targeting of TNF-alpha in the lung may prevent smokers progressing to COPD...
  28. ncbi Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial
    Ralf Eberhardt
    Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany
    Am J Respir Crit Care Med 176:36-41. 2007
    Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions...
  29. pmc Electromagnetic navigation diagnostic bronchoscopy: a prospective study
    Thomas R Gildea
    Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 174:982-9. 2006
    Electromagnetic navigation bronchoscopy using superDimension/Bronchus System is a novel method to increase diagnostic yield of peripheral and mediastinal lung lesions.
  30. ncbi Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity
    P K Jeffery
    Department of Lung Pathology, National Heart and Lung Institute, London, England, U K
    Am Rev Respir Dis 140:1745-53. 1989
    ..We have studied the light and electron microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy from 11 atopic asthmatics, four of whom were symptomatic and seven of whom were asymptomatic...
  31. doi Impact of a Mycobacterium tuberculosis-specific interferon-γ release assay in bronchoalveolar lavage fluid for a rapid diagnosis of tuberculosis
    C Jafari
    Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany
    J Intern Med 270:254-62. 2011
    ..Evaluation of different methods for an initial treatment decision in individuals with suspected pulmonary tuberculosis...
  32. ncbi Tracheobronchial foreign bodies in children: importance of accurate history and plain chest radiography in delayed presentation
    B Tokar
    Departments of Paediatric Surgery and Radiology, Osmangazi University Faculty of Medicine, Eskisehir, Turkey
    Clin Radiol 59:609-15. 2004
    ..To evaluate the factors associated with delayed diagnosis of foreign body aspiration (FBA) in children and to compare clinical, radiological and bronchoscopic findings in the patients with suspected FBA...
  33. doi The utility of bronchoscopy after inhalation injury complicated by pneumonia in burn patients: results from the National Burn Repository
    John Alfred Carr
    Division of Trauma and Burn Surgery, Hurley Medical Center, Flint, Michigan 48503, USA
    J Burn Care Res 30:967-74. 2009
    There are no guidelines to determine when bronchoscopy is appropriate in patients with inhalation injury complicated by pneumonia...
  34. ncbi EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy
    Jouke T Annema
    Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 48:357-61; discussion 363-4. 2005
    To assess the feasibility and yield of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) in diagnosing centrally located lung tumours after a previously non-diagnostic bronchoscopy.
  35. doi Cluster of pseudoinfections with Burkholderia cepacia associated with a contaminated washer-disinfector in a bronchoscopy unit
    Dror Rosengarten
    Institute of Pulmonology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Infect Control Hosp Epidemiol 31:769-71. 2010
    ..cepacia complex. The cause of this pseudo-outbreak was that the washer-disinfector was installed without the required antibacterial filter...
  36. ncbi Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysema
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Department of Respiratory Medicine, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:453-60. 2005
    ..47; p = 0.03). Endobronchial valve placement can improve lung volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolong exercise time by reducing dynamic hyperinflation...
  37. ncbi Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma
    W J Elston
    Dept of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX, UK
    Eur Respir J 24:375-7. 2004
    b>Bronchoscopy with endobronchial biopsy (EBB) and/or bronchoalveolar lavage (BAL) has become an important research tool in asthma. A recent report has suggested audit and reporting of the safety of these procedures...
  38. ncbi Electromagnetic navigation diagnostic bronchoscopy for small peripheral lung lesions
    D Makris
    Clinic of Respiratory Disease, Department of Anatomopathology, Albert Calmette Hospital, Centre Hospitalier Régional University of Lille, 59037 Lille, France
    Eur Respir J 29:1187-92. 2007
    The present study prospectively evaluated the diagnostic yield and safety of electromagnetic navigation-guided bronchoscopy biopsy, for small peripheral lung lesions in patients where standard techniques were nondiagnostic...
  39. ncbi Bronchial anthracofibrosis and tuberculosis in immigrants to Canada from the Indian subcontinent
    J Hwang
    Department of Pathology, University of Alberta, Edmonton, Alberta, Canada
    Int J Tuberc Lung Dis 14:231-7. 2010
    ..It is a bronchoscopic finding that is not uncommonly associated with pulmonary tuberculosis (PTB) in residents of South Korea, Iran and India. It is largely unrecognized in the Western world...
  40. doi Benign fibroepithelial polyp arising in the bronchus: a case report and review of the literature
    Parth B Amin
    Department of Surgery, Wayne State University and Detroit Medical Center, Detroit, Michigan, USA
    Arch Surg 144:1081-3. 2009
    ..We describe a man with repeated visits to emergency departments for coughing spells who ultimately underwent bronchoscopy and biopsy...
  41. ncbi Endoscopic ultrasound-guided fine needle aspiration in the evaluation of suspected lung cancer
    T L Ang
    Division of Gastroenterology, Changi General Hospital, 2 Simei St 3, Singapore 529889, Singapore
    Respir Med 101:1299-304. 2007
    ..This prospective study aimed to define the effectiveness of EUS-FNA as an adjunct to computer tomography (CT) and bronchoscopy in the evaluation of suspected lung cancer in routine clinical practice.
  42. ncbi Fibreoptic bronchoscopy in routine clinical practice in confirming the diagnosis and treatment of inhalation burns
    Kawecki Marek
    Burn Centre, Siemianowice, Slaskie, Poland
    Burns 33:554-60. 2007
    Fibreoptic bronchoscopy has been recently introduced to our practice, its value in the diagnosis and management of respiratory tract burns has been well established...
  43. ncbi Respiratory management of inhalation injury
    Ronald P Mlcak
    Respiratory Care Department, Shriners Hospital for Children, Galveston, TX, USA
    Burns 33:2-13. 2007
    ..It is imperative that a well organized, protocol driven approach to respiratory care of inhalation injury be utilized so that improvements can be made and the morbidity and mortality associated with inhalation injury be reduced...
  44. pmc Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers
    J M Löfdahl
    Department of Medicine, Division of Respiratory Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Clin Exp Immunol 145:428-37. 2006
    ..Some alterations were found in smokers compared to non-smokers, thus indicating that changes in AM phenotype may be associated with smoking per se. The functional relevance of our findings remains to be elucidated...
  45. doi Optical coherence tomography as an adjunct to flexible bronchoscopy in the diagnosis of lung cancer: a pilot study
    Ross G Michel
    Division of Pulmonary Critical Care Medicine, Oklahoma City Veterans Affairs Medical Center and University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 5020, USA
    Chest 138:984-8. 2010
    ..The objectives of this study were to determine the feasibility of using OCT imaging during flexible bronchoscopy and to preliminarily assess the ability of OCT imaging to distinguish an endobronchial malignancy from normal ..
  46. doi Mediastinoscopy: still the gold standard
    Joseph B Shrager
    Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    Ann Thorac Surg 89:S2084-9. 2010
    ..There are scenarios in which EBUS is preferable to mediastinoscopy. However, for routine staging of the upper mediastinum in non-small cell lung cancer, the benefits of EBUS over mediastinoscopy remain unproven...
  47. doi EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncologic Network, Ghent University Hospital, Ghent, Belgium
    Lung Cancer 63:45-9. 2009
    ..Obtaining a tissue diagnosis of malignancy is challenging in patients with suspected lung cancer presenting with centrally located intrapulmonary masses...
  48. ncbi Diagnostic results before and after introduction of autofluorescence bronchoscopy in patients suspected of having lung cancer detected by sputum cytology in lung cancer mass screening
    M Sato
    Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, 980 8575, Sendai, Japan
    Lung Cancer 32:247-53. 2001
    ..To clarify the role of autofluorescence bronchoscopy in localizing tumors in patients with roentgenographically occult cancer, we analyzed our diagnostic results...
  49. doi Fiberoptic bronchoscopy-assisted percutaneous tracheostomy is safe in obese critically ill patients: a prospective and comparative study
    Carlos M Romero
    Critical Care Unit, University of Chile Clinical Hospital, Santiago Norte, Chile
    J Crit Care 24:494-500. 2009
    ..In Latin America, 10% to 35% of the population is obese. Obese critically ill patients are at greater risk for requiring intubation and prolonged mechanical ventilation; and in some cases, it is necessary to perform a tracheostomy...
  50. doi Natural stent in the management of post-intubation tracheal stenosis
    Hye Yun Park
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Respirology 14:583-8. 2009
    ..A new silicone stent, called the Natural stent (N stent), was investigated for its clinical efficacy and safety in patients with PITS...
  51. pmc Advances in diagnostic bronchoscopy
    Andrew R Haas
    Clinical Operations, Interventional Pulmonology and Thoracic Oncology, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Respir Crit Care Med 182:589-97. 2010
    Diagnostic bronchoscopy has undergone two major paradigm shifts in the last 40 years...
  52. doi Electromagnetic navigation bronchoscopy (ENB): Increasing diagnostic yield
    B Lamprecht
    Department of Pulmonary Medicine, Paracelsus Medical University Hospital, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Respir Med 106:710-5. 2012
    ..To determine factors associated with diagnostic yield of ENB...
  53. doi Bronchoscopic findings in children with chronic wet cough
    Daniela Zgherea
    Department of Pediatrics, Maimonides Infants and Children s Hospital of Brooklyn, Brooklyn, NY, USA
    Pediatrics 129:e364-9. 2012
    ..The objective of this study was to determine the frequency of bacterial bronchitis in children with chronic wet cough and to analyze their bronchoscopic findings...
  54. doi Outcomes of airway stenting for advanced lung cancer with central airway obstruction
    Hisashi Saji
    Department of Thoracic Surgery and Oncology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Interact Cardiovasc Thorac Surg 11:425-8. 2010
    ..Interventional therapeutic bronchoscopy including airway stenting (AS) providing immediate and effective palliation is therefore essential to improve ..
  55. doi Bronchoscopy for the diagnosis and staging of lung cancer
    Ezzat El-Bayoumi
    Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Respir Crit Care Med 29:261-70. 2008
    b>Bronchoscopy is an invaluable tool utilized for the diagnosis, staging, and management of lung cancer...
  56. ncbi The potential for bronchoscopic lung volume reduction using bronchial prostheses: a pilot study
    Gregory I Snell
    Department of Respiratory Medicine, Alfred Hospital, Melbourne, Victoria 3004, Australia
    Chest 124:1073-80. 2003
    ..The purpose of this study was to investigate the safety and feasibility of placing valves in segmental airways of patients with emphysema...
  57. ncbi Bronchoscopic measurement of collateral ventilation in a sheep model of emphysema
    Larry W Tsai
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Respiration 74:565-71. 2007
    ..Furthermore, the validity of various animal models of emphysema for testing such techniques must be understood in the context of their species-specific collateral ventilation...
  58. ncbi MDCT of the central airways: comparison with bronchoscopy in the evaluation of complications of endotracheal and tracheostomy tubes
    Maryellen Sun
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Imaging 22:136-42. 2007
    To evaluate the accuracy of multidetector row computed tomography (MDCT) compared with bronchoscopy in the assessment of airway complications related to endotracheal and tracheostomy tubes.
  59. doi Prospective controlled animal study on biopsy sampling with new flexible cryoprobes versus forceps: evaluation of biopsy size, histological quality and bleeding risk
    Karl Josef Franke
    Department of Pneumology and Critical Care Medicine, Helios Klinik Ambrock, University of Witten Herdecke, Hagen, Germany
    Respiration 80:127-32. 2010
    ..Cryoextraction is a procedure used for the recanalization of obstructed airways caused by visible exophytic endobronchial tumor. Biopsy samples obtained by this technique have been shown to be useful for histological assessment...
  60. ncbi Tissue diagnosis of suspected lung cancer: selecting between bronchoscopy, transthoracic needle aspiration, and resectional biopsy
    Rex C W Yung
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Jefferson B1 170, 600 North Wolfe Street, Baltimore, MD 21287 8922, USA
    Respir Care Clin N Am 9:51-76. 2003
    ..b>Bronchoscopy with direct examination of the visible airways is most often the preferred invasive diagnostic procedure...
  61. doi Rapid on-site evaluation of transbronchial aspirates in the diagnosis of hilar and mediastinal adenopathy: a randomized trial
    Rocco Trisolini
    Thoracic Endoscopy and Pulmonology Unit, Maggiore Hospital, Largo B Nigrisoli 2, 40133 Bologna, Italy
    Chest 139:395-401. 2011
    Rapid on-site evaluation (ROSE) of transbronchial needle aspirates has long been used during flexible bronchoscopy, but its usefulness in the diagnosis of hilar and mediastinal adenopathy is controversial...
  62. doi Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    P Bhavsar
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 63:784-90. 2008
    ....
  63. doi Efficacy of endobronchial ultrasound-guided transbronchial needle aspiration of hilar lymph nodes for diagnosing and staging cancer
    Armin Ernst
    Department of Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Thorac Oncol 4:947-50. 2009
    ..We sought to determine the efficacy of EBUS-TBNA in sampling enlarged hilar lymph nodes in this patient population...
  64. doi Human in vivo fluorescence microimaging of the alveolar ducts and sacs during bronchoscopy
    L Thiberville
    Clinique Pneumologique, Hopital Charles Nicolle, CHU de Rouen, Rouen Cedex, France
    Eur Respir J 33:974-85. 2009
    ..confocal fluorescence microscopy (FCFM) as a tool for imaging the alveolar respiratory system in vivo during bronchoscopy. A 488-nm excitation wavelength FCFM device was used in 41 healthy subjects including 17 active smokers...
  65. ncbi Photodynamic therapy for lung cancers based on novel photodynamic diagnosis using talaporfin sodium (NPe6) and autofluorescence bronchoscopy
    Jitsuo Usuda
    Department of Thoracic Surgery, Tokyo Medical University Hospital, Tokyo 160 0023, Japan
    Lung Cancer 58:317-23. 2007
    ..Recently, we established the autofluorescence diagnosis system integrated into a videoendoscope (SAFE-3000) as a very useful technique for the early diagnosis of lung cancer...
  66. doi Endobronchial ultrasound-guided transbronchial fine-needle aspiration: the University of Minnesota experience, with emphasis on usefulness, adequacy assessment, and diagnostic difficulties
    Mariam Alsharif
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Clin Pathol 130:434-43. 2008
    ..For pathologists, this was a relatively time-consuming procedure. Recognizing bronchial contamination, especially with metaplastic or dysplastic cells, is important for avoiding diagnostic pitfalls...
  67. pmc Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes: a study in a tuberculosis-endemic country
    Chih Hsi Kuo
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan
    PLoS ONE 6:e16877. 2011
    ..This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET...
  68. ncbi Diagnostic yield of bronchoscopy with bronchoalveolar lavage in febrile patients with hematologic malignancies and pulmonary infiltrates
    Margit Hummel
    3 Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Ann Hematol 87:291-7. 2008
    ..The diagnostic value of fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) in these patients is controversial...
  69. ncbi Impact of rapid on-site cytologic evaluation during transbronchial needle aspiration
    Daniel Baram
    Division of Pulmonary Critical Care, Stony Brook University, T 17, 040 HSC, Stony Brook, NY 11794 8172, USA
    Chest 128:869-75. 2005
    To determine the extent to which rapid on-site cytologic evaluation (ROSE) of transbronchial needle aspiration (TBNA) samples can safely and cost-effectively reduce the need for additional biopsy during bronchoscopy.
  70. ncbi Cryosurgery for malignant endobronchial tumors: analysis of outcome
    George Asimakopoulos
    Department of Thoracic Surgery, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
    Chest 127:2007-14. 2005
    ..Endobronchial cryosurgery is used for destruction of intraluminal tumors. This study analyzes the effects of cryosurgery on patients with obstructive endobronchial carcinoma...
  71. ncbi Cryorecanalization: a new approach for the immediate management of acute airway obstruction
    Martin Hetzel
    Department of Internal Medicine II Pulmonary Medicine, University Medical Center Ulm, Ulm, Germany
    J Thorac Cardiovasc Surg 127:1427-31. 2004
    ..In this study we demonstrate a newly developed cryoprobe allowing recanalization of tumor stenoses during a single intervention...
  72. doi Validation of two instruments to assess technical bronchoscopic skill using virtual reality simulation
    Mohsen Davoudi
    Medical Center, University of California, Irvine, CA 92868, USA
    Respiration 76:92-101. 2008
    In an era of increased emphasis on patient safety and competency-based education, demonstration of significant variability in the teaching of flexible bronchoscopy has led to initiatives for new standardized curricula and assessment tools.
  73. pmc Investigative bronchoprovocation and bronchoscopy in airway diseases
    William W Busse
    University of Wisconsin Madison, USA
    Am J Respir Crit Care Med 172:807-16. 2005
    ..Basic and clinical research strategies used for many lung diseases have depended on volunteer subjects undergoing bronchoscopy to establish access to the airways to collect biological specimens and tissue, perhaps with added ..
  74. doi The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma
    Jerzy Soja
    Department of Medicine, Jagiellonian University, Krakow 31 066, Poland
    Chest 136:797-804. 2009
    ..Endobronchial ultrasound (EBUS) is a new technique that enables the assessment of bronchial wall layers. The aim of the study was to verify the utility of EBUS for the assessment of bronchial wall remodeling in patients with asthma...
  75. doi Reliability of a 25-item low-stakes multiple-choice assessment of bronchoscopic knowledge
    Silvia Quadrelli
    Instituto de Investigaciones Medicas Alfredo Lanari, Buenos Aires, Argentina
    Chest 135:315-21. 2009
    ..Assessment tools related to bronchoscopy training, however, have not yet been developed or validated.
  76. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  77. doi Minimally invasive endoscopic staging of suspected lung cancer
    Michael B Wallace
    Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA
    JAMA 299:540-6. 2008
    ..Invasive staging with pathologic confirmation is recommended. Many methods for staging exist; mediastinoscopy, an invasive procedure requiring general anesthesia, is currently regarded as the diagnostic standard...
  78. ncbi Electromagnetic navigation diagnostic bronchoscopy in peripheral lung lesions
    Ralf Eberhardt
    Department of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Germany
    Chest 131:1800-5. 2007
    Electromagnetic navigation bronchoscopy (ENB) with biopsy under fluoroscopic guidance has enhanced the yield of flexible bronchoscopy in the diagnosis of peripheral lung lesions...
  79. ncbi Bronchoscopic volume reduction with valve implants in patients with severe emphysema
    Tudor P Toma
    Department of Thoracic Medicine, National Heart and Lung Institute, London, UK
    Lancet 361:931-3. 2003
    ..Lung-volume reduction can be achieved with unilateral bronchoscopically placed valve implants in patients with severe emphysema with acceptable short-term safety and worthwhile functional benefits...
  80. ncbi A pilot study of narrow-band imaging compared to white light bronchoscopy for evaluation of normal airways and premalignant and malignant airways disease
    Brad D Vincent
    Department of Internal Medicine, Division of Pulmonary and Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA
    Chest 131:1794-9. 2007
    ..normal, dysplastic, and frankly malignant airway lesion appearance under narrow-band imaging (NBI), and to determine if NBI, when used in conjunction with white light (WL) bronchoscopy, could improve detection of dysplasia and malignancy.
  81. pmc Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial
    Eric Edell
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
    J Thorac Oncol 4:49-54. 2009
    ..A secondary objective was to evaluate the potential use of quantitative image analysis with this device for objective classification of abnormal sites...
  82. ncbi Laser resection of a pedunculated tracheal adenoma
    M T Newhouse
    St Joseph s Hospital McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, Canada
    Chest 118:262-6. 2000
    ..Two-stage bronchoscopic laser resection resulted in an apparently normal tracheal mucosa. Results of postresection spirometry were normal...
  83. ncbi Utility of on-site cytopathology assessment for bronchoscopic evaluation of lung masses and adenopathy
    G B Diette
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 117:1186-90. 2000
    To determine the extent to which on-site cytopathology assessment improves diagnostic yield when sampling lung nodules or masses and/or hilar or mediastinal lymphadenopathy by fiberoptic bronchoscopy (FOB).
  84. doi Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition
    S Hodge
    Lung Research Laboratory, Hanson Institute, Adelaide, Australia
    Am J Transplant 9:727-33. 2009
    ..Flow cytometric evaluation of bronchial epithelium may provide a novel and rapid means to assess lung allografts at risk of BOS...
  85. ncbi Bronchoscopy with bronchoalveolar lavage via the laryngeal mask airway in high-risk hypoxemic immunosuppressed patients
    G Hilbert
    Medical Intensive Care Unit, Pellegrin Hospital, Bordeaux, France
    Crit Care Med 29:249-55. 2001
    OBJECTIVE: Fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) are major tools in the diagnosis of pulmonary complications in immunocompromised patients...
  86. ncbi Endobronchial hamartoma
    Borja G Cosio
    Respiratory Department, Hospital 12 de Octubre, Madrid, Spain
    Chest 122:202-5. 2002
    ..To describe clinical, endoscopic, radiographic, and follow-up characteristics of a series of patients in whom endobronchial hamartoma (EH) had been diagnosed...
  87. ncbi Cryotherapy in early superficial bronchogenic carcinoma
    N Deygas
    Service de Pneumologie et d'Oncologie Thoracique, , Saint-Etienne, France
    Chest 120:26-31. 2001
    ..Patients and methods: Patients included in the study had histologically proven ESBC after fiberoptic bronchoscopy. Cryotherapy was performed through a rigid bronchoscope...
  88. ncbi Ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, France
    Am J Respir Crit Care Med 165:867-903. 2002
    ..When fiberoptic bronchoscopy is not available to physicians treating patients clinically suspected of having VAP, we recommend using either ..
  89. ncbi Investigation of young children with severe recurrent wheeze: any clinical benefit?
    S Saglani
    Dept of Respiratory Paediatrics, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Respir J 27:29-35. 2006
    ..of investigations including a chest computed tomography scan, blood tests, nasal ciliary brushings, fibreoptic bronchoscopy, bronchoalveolar lavage (BAL), endobronchial biopsy and passage of an oesophageal pH probe...
  90. ncbi Bronchoscopic lung-volume reduction with one-way valves in patients with heterogenous emphysema
    Federico Venuta
    Department of Thoracic Surgery, University of Rome La Sapienza, Rome, Italy
    Ann Thorac Surg 79:411-6; discussion 416-7. 2005
    ..We evaluated the feasibility and short-term functional outcome after bronchoscopic lung-volume reduction performed with one-way valves in patients with severe heterogeneous emphysema...
  91. ncbi Bronchoalveolar lavage in COPD: fluid recovery correlates with the degree of emphysema
    J M Löfdahl
    Dept of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    Eur Respir J 25:275-81. 2005
    b>Bronchoscopy with bronchoalveolar lavage (BAL) is an important research tool for assessing airway inflammation in a variety of inflammatory lung diseases...
  92. ncbi A comparison of video and autofluorescence bronchoscopy in patients at high risk of lung cancer
    P N Chhajed
    Dept of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Respir J 25:951-5. 2005
    The aim of this study was to compare the diagnostic yield of flexible video bronchoscopy (FVB) and autofluorescence bronchoscopy (i.e...
  93. ncbi Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    S E Wenzel
    Departments of Medicine, Medical College of Virginia, Richmond, Virginia, USA
    Am J Respir Crit Care Med 160:1001-8. 1999
    ..These results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment...
  94. doi Transbronchial cryobiopsy: a new tool for lung biopsies
    Alexander Babiak
    Department of Pulmonary Medicine, Red Cross Medical Center, Stuttgart, Germany
    Respiration 78:203-8. 2009
    ..Flexible cryoprobes have been shown to be useful in therapeutic bronchoscopy. We introduce a novel technique for obtaining lung biopsies bronchoscopically, using a flexible cryoprobe.
  95. ncbi Multidetector CT virtual bronchoscopy to grade tracheobronchial stenosis
    Hanno Hoppe
    Institute of Diagnostic Radiology, Inselspital, University of Berne, Freiburgstr 20, CH 3010 Berne, Switzerland
    AJR Am J Roentgenol 178:1195-200. 2002
    ..multidetector CT (virtual bronchoscopic images, axial CT slices, coronal reformatted images, and sagittal reformatted images) in depicting and allowing accurate grading of tracheobronchial stenosis with that of flexible bronchoscopy.
  96. pmc Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial
    D Stolz
    Division of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland
    Thorax 59:773-6. 2004
    ..Society guidelines do not recommend routinely the combined use of a benzodiazepine and opiate during flexible bronchoscopy (FB)...
  97. ncbi Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data
    Elie Azoulay
    Intensive Care Unit, Saint Louis Teaching Hospital, Paris, France
    Crit Care Med 36:100-7. 2008
    To describe the diagnostic yields of test strategies with and without fiberoptic bronchoscopy and bronchoalveolar lavage (FO-BAL), as well as outcomes, in cancer patients with acute respiratory failure (ARF).
  98. doi A rapidly enlarging neck mass: the role of the sitting position in fiberoptic bronchoscopy for difficult intubation
    Ali Dabbagh
    Department of Anesthesiology and Anesthesia Research Center, Shahid Beheshti University, M C Tehran, Iran
    Anesth Analg 107:1627-9. 2008
    ..Therefore, there were few safe strategies for airway management for general anesthesia. We reiterate the role of awake fiberoptic intubation in such circumstances...
  99. ncbi Fibroepithelial polyps: preoperative diagnosis may avoid thoracotomy
    Christopher T Wartmann
    Department of Surgery, Northwestern University, Chicago, Ill, USA
    J Thorac Cardiovasc Surg 134:1080-1. 2007
  100. ncbi Virtual bronchoscopy for diagnosis of inhalation injury in burnt patients
    Madhuri A Gore
    Department of General Surgery, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai 400022, India
    Burns 30:165-8. 2004
    Virtual bronchoscopy using a multislice CT scanner, is a new non-invasive imaging technique and its utility in the diagnosis of inhalation injury in burnt patients has not been reported in literature yet...
  101. ncbi Early detection of bronchial lesions using newly developed videoendoscopy-based autofluorescence bronchoscopy
    Norihiko Ikeda
    Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan
    Lung Cancer 52:21-7. 2006
    The combination of white light and autofluorescence bronchoscopy has been reported to show better sensitivity in detecting dysplasia and cancer of the bronchus than white light alone...

Research Grants83

  1. Improving Colonoscopy Quality through Automated Monitoring
    Piet C de Groen; Fiscal Year: 2010
    ..to other endoscopic medical procedures such as upper gastrointestinal endoscopy, cystoscopy, arthroscopy and bronchoscopy. PUBLIC HEALTH RELEVANCE: Our long-term objective is to ensure that all endoscopic examinations of the colon, ..
  2. Improving Colonoscopy Quality through Automated Monitoring
    Piet C de Groen; Fiscal Year: 2010
    ..to other endoscopic medical procedures such as upper gastrointestinal endoscopy, cystoscopy, arthroscopy and bronchoscopy. Our long-term objective is to ensure that all endoscopic examinations of the colon, so called colonoscopies, ..
  3. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip Boiselle; Fiscal Year: 2009
    ..noninvasive method for diagnosing tracheomalacia, with comparable accuracy to the current gold standard of bronchoscopy, an invasive procedure...
  4. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..tuberculosis (TB) and bacterial pneumonia are common, other processes may cause pneumonia in these patients, so bronchoscopy with bronchoalveolar lavage (BAL) is often indicated for definitive diagnosis, especially when empiric ..
  5. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2010
    ..We will also collect serum, oropharyngeal wash, Scope mouthwash, sputum, and bronchoscopy specimens to address hypothesis-driven research questions...
  6. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2009
    ..We will also collect serum, oropharyngeal wash, Scope mouthwash, sputum, and bronchoscopy specimens to address hypothesis-driven research questions...
  7. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2004
    ..3) To develop methods to measure the pressure-area characteristics of the trachea in patients undergoing bronchoscopy and to determine whether the site of expiratory flow limitation in these patients is in the lungs or trachea...
  8. International HIV-associated Opportunistic Pneumonias (IHOP) Study
    Laurence Huang; Fiscal Year: 2009
    ..We will also collect serum, oropharyngeal wash, Scope mouthwash, sputum, and bronchoscopy specimens to address hypothesis-driven research questions...
  9. GOBLET CELL DYSFUNCTION IN ASTHMA
    John Fahy; Fiscal Year: 2002
    ..goblet cell degranulation, and goblet cell expression of mucin genes in endobronchial biopsies obtained during bronchoscopy from healthy and asthmatic subjects...
  10. Patient-Oriented Research and Mentoring in Pneumocystis
    Laurence Huang; Fiscal Year: 2007
    ..A total of 200 enrolled subjects will provide oropharyngeal washing (OPW, gargle) specimens and will undergo bronchoscopy with bronchoalveolar lavage (BAL) for the diagnosis of PCP and TB...
  11. Synergistic CT-Bronchoscopy for Lung-Cancer Assessment
    William Higgins; Fiscal Year: 2007
    ..It is driven by the following hypothesis: A synergistic combination of 3D MDCT imaging, image processing, and bronchoscopy improves current procedures for the staging, diagnosis, and treatment of lung cancer...
  12. PATHOPHYSIOLOGY OF EXERCISE-INDUCED ASTHMA
    EDWARD MCFADDEN; Fiscal Year: 1993
    ..On other occasion they will undergo bronchoscopy with insertion of a thermal probe and will repeat the above challenges, in all particulars while airstream ..
  13. Role of Th2 and non-Th2 Inflammation in Airway Smooth Muscle Remodeling in Asthma
    Prescott G Woodruff; Fiscal Year: 2010
    ..These studies will be performed in vivo by applying bronchoscopy, design-based stereology, laser capture microdissection and genomics in a detailed study of asthmatics and ..
  14. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2007
    ..test this hypothesis, we will recruit subjects with mild and severe asthma and normal controls who will undergo bronchoscopy with proximal (endobronchial) and distal (transbronchial) lung biopsy...
  15. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..test this hypothesis, we will recruit subjects with mild and severe asthma and normal controls who will undergo bronchoscopy with proximal (endobronchial) and distal (transbronchial) lung biopsy...
  16. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2009
    ..test this hypothesis, we will recruit subjects with mild and severe asthma and normal controls who will undergo bronchoscopy with proximal (endobronchial) and distal (transbronchial) lung biopsy...
  17. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip Boiselle; Fiscal Year: 2009
    ..noninvasive method for diagnosing tracheomalacia, with comparable accuracy to the current gold standard of bronchoscopy, an invasive procedure...
  18. CT Diagnosis of Tracheomalacia in Patients with COPD
    Phillip M Boiselle; Fiscal Year: 2010
    ..noninvasive method for diagnosing tracheomalacia, with comparable accuracy to the current gold standard of bronchoscopy, an invasive procedure...
  19. Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
    ERIK LANGE; Fiscal Year: 2006
    ..b>Bronchoscopy is used to locate anomalies in a patient's bronchus and if necessary, take a biopsy...
  20. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ..for sequencing, genotyping and haplotyping candidate genes, and determination of levels of gene expression in bronchoscopy samples; 2) identified in the Department of Public Health Sciences (PHS) to a) assist in the analysis of data ..
  21. MULTIDAY EXPOSURE TO O3 IN ASTHMA
    John Balmes; Fiscal Year: 2002
    ..respiratory tract inflammation in healthy and asthmatic subjects has been generated from studies involving bronchoscopy and analysis of bronchoalveolar lavage (BAL) fluid...
  22. Linking airway genomics to the pathogenesis and clinical heterogeneity of COPD
    AVRUM E contact SPIRA; Fiscal Year: 2010
    ..field of injury", and gene expression in bronchial airway cells of smokers obtained by brushings at bronchoscopy reflects both this injury and subsequent disease-specific processes...
  23. Quantitative PCR for the Detection of Fungal Infections
    David Fredricks; Fiscal Year: 2007
    ..Fungal qPCR performed on BAL fluid will increase the yield from bronchoscopy, reducing the need for open lung biopsies...