eye color

Summary

Summary: Color of the iris.

Top Publications

  1. ncbi Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
    V Lloyd
    Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
    Trends Cell Biol 8:257-9. 1998
  2. ncbi A golden age of human pigmentation genetics
    Richard A Sturm
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Trends Genet 22:464-8. 2006
  3. ncbi The influence of social status on the rate of growth, eye color pattern and insulin-like growth factor-I gene expression in Nile tilapia, Oreochromis niloticus
    Emmanuel M Vera Cruz
    Department of Biological Sciences, Florida International University, North Miami, Florida 33181, USA
    Horm Behav 51:611-9. 2007
  4. pmc A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    Am J Hum Genet 82:424-31. 2008
  5. doi Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression
    Hans Eiberg
    Department of Cellular and Molecular Medicine, Section IV Build 24 4, Panum Institute, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Hum Genet 123:177-87. 2008
  6. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
  7. pmc Digital quantification of human eye color highlights genetic association of three new loci
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000934. 2010
  8. doi Two newly identified genetic determinants of pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:835-7. 2008
  9. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007
  10. doi Molecular genetics of human pigmentation diversity
    Richard A Sturm
    Melanogenix Group, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
    Hum Mol Genet 18:R9-17. 2009

Research Grants

Detail Information

Publications172 found, 100 shown here

  1. ncbi Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
    V Lloyd
    Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
    Trends Cell Biol 8:257-9. 1998
    ..Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes...
  2. ncbi A golden age of human pigmentation genetics
    Richard A Sturm
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Trends Genet 22:464-8. 2006
    ..SLC24A5 promotes melanin deposition through maturation of the melanosome, highlighting the importance of ion-exchange in the function of this organelle...
  3. ncbi The influence of social status on the rate of growth, eye color pattern and insulin-like growth factor-I gene expression in Nile tilapia, Oreochromis niloticus
    Emmanuel M Vera Cruz
    Department of Biological Sciences, Florida International University, North Miami, Florida 33181, USA
    Horm Behav 51:611-9. 2007
    ..To evaluate the relationship of social status with growth, eye color pattern and hepatic Insulin-like Growth Factor-I (IGF-I) mRNA expression, 30 Oreochromis niloticus were isolated ..
  4. pmc A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    Am J Hum Genet 82:424-31. 2008
    ..SNPs) within the first intron of the OCA2 gene are extremely strongly associated with variation in human eye color. In the present work, we describe additional fine association mapping of eye color SNPs in the intergenic region ..
  5. doi Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression
    Hans Eiberg
    Department of Cellular and Molecular Medicine, Section IV Build 24 4, Panum Institute, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Hum Genet 123:177-87. 2008
    The human eye color is a quantitative trait displaying multifactorial inheritance. Several studies have shown that the OCA2 locus is the major contributor to the human eye color variation...
  6. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin.
  7. pmc Digital quantification of human eye color highlights genetic association of three new loci
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000934. 2010
    ..Here, we quantified continuous eye color variation into hue and saturation values using high-resolution digital full-eye photographs and conducted a ..
  8. doi Two newly identified genetic determinants of pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:835-7. 2008
    ....
  9. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007
    ..shown that a quantitative-trait locus linked to the OCA2 region of 15q accounts for 74% of variation in human eye color. We conducted additional genotyping to clarify the role of the OCA2 locus in the inheritance of eye color and ..
  10. doi Molecular genetics of human pigmentation diversity
    Richard A Sturm
    Melanogenix Group, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
    Hum Mol Genet 18:R9-17. 2009
    ..From a culmination of genetic and functional studies, it is apparent that a number of genes impacting melanosome biogenesis or the melanin biosynthetic pathway are candidates to explain the diversity seen in human pigmentation...
  11. doi IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 5:170-80. 2011
    ....
  12. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
    ..hair color, a variant near KITLG is associated with hair color, two coding variants in TYR are associated with eye color and freckles, and a variant on 6p25.3 is associated with freckles...
  13. pmc Sequences associated with human iris pigmentation
    Tony Frudakis
    DNAPrint Genomics, Sarasota, Florida 34236, USA
    Genetics 165:2071-83. 2003
    ....
  14. doi Prediction of eye and skin color in diverse populations using seven SNPs
    Olga Spichenok
    Office of Chief Medical Examiner of the City of New York, Department of Forensic Biology, 421 East 26th Street, New York, NY, USA
    Forensic Sci Int Genet 5:472-8. 2011
    ..Six SNPs were used in predicting the eye color of an individual, and all seven were used to describe the skin coloration...
  15. ncbi P gene mutations associated with oculocutaneous albinism type II (OCA2)
    William S Oetting
    Department of Medicine, Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Hum Mutat 25:323. 2005
    ..This information will also help define the critical functional domains of the P protein. Mutations associated with OCA2 can be found in the Albinism Database (http://albinismdb.med.umn.edu)...
  16. doi Further development of forensic eye color predictive tests
    Y Ruiz
    Forensic Genetics Unit, Institute of Legal Medicine, University of Santiago de Compostela, Spain
    Forensic Sci Int Genet 7:28-40. 2013
    ..both focused on forensic testing, have analyzed single nucleotide polymorphism (SNP) genotypes underlying common eye color variation (Mengel-From et al., Forensic Sci. Int. Genet. 4:323 and Walsh et al., Forensic Sci. Int. Genet...
  17. doi The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Forensic Sci Int Genet 7:98-115. 2013
    ....
  18. doi DNA-based eye colour prediction across Europe with the IrisPlex system
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:330-40. 2012
    ....
  19. doi Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci
    Anthony L Cook
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Queensland, Australia
    J Invest Dermatol 129:392-405. 2009
    ....
  20. doi Human eye colour and HERC2, OCA2 and MATP
    Jonas Mengel-From
    Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, 11 Frederik V s Vej, DK 2100 Copenhagen, Denmark
    Forensic Sci Int Genet 4:323-8. 2010
    ..Diplotype analysis of three sequence variations in HERC2 and one sequence variation in OCA2 showed the best discrimination between light and dark eye colours with a likelihood ratio of 29.3...
  21. pmc Predicting phenotype from genotype: normal pigmentation
    Robert K Valenzuela
    Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    J Forensic Sci 55:315-22. 2010
    ..or animal pigmentation studies) for the analysis of single- and multi-locus associations with hair, skin, and eye color in 789 individuals of various ethnic backgrounds...
  22. ncbi Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma
    Anne Sophie Jannot
    Unite INSERM 535 Génétique Epidémiologique et Structure des Populations Humaines, Hopital Paul Brousse, Villejuif, France
    Eur J Hum Genet 13:913-20. 2005
    ..Our data demonstrate that a second pigmentation gene, in addition to MC1R, is involved in genetic susceptibility to melanoma...
  23. ncbi Prediction of eye color from genetic data using Bayesian approach
    Ewelina Pośpiech
    Section of Forensic Genetics, Institute of Forensic Research, Krakow, Poland
    J Forensic Sci 57:880-6. 2012
    ..Here, on the basis of genetic data for the six most relevant eye color predictors, two alternative Bayesian network model variants were developed and evaluated for their accuracy in ..
  24. doi Verification of eye and skin color predictors in various populations
    Amanda Pneuman
    Department of Forensic Biology, Office of Chief Medical Examiner of the City of New York, 421 E 26th Street, New York, NY, USA
    Leg Med (Tokyo) 14:78-83. 2012
    ..the predictor that describes individual eye colors (blue, brown, and intermediate/green), because of uncertainties with the green eye color prediction. Our investigation deepens the insight for these predictors and adds new information.
  25. pmc A global view of the OCA2-HERC2 region and pigmentation
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Genet 131:683-96. 2012
    ..Our data suggest that the haplotype restricted to Europe is the strongest marker for blue eyes globally and add further inferential evidence that the derived allele of rs1800414 is an East Asian skin pigmentation allele...
  26. ncbi Analysis of systematic effects on congenital sensorineural deafness in German Dalmatian dogs
    K Juraschko
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, 30559, Hannover, Germany
    Vet J 166:164-9. 2003
    ..53+/-0.41 and with presence of patches r(g)=-0.36+/-0.24. We concluded that additional genes other than those associated with phenotypic colour markers in German Dalmatian dogs significantly contribute to the occurrence of CSD...
  27. ncbi Interactions between HERC2, OCA2 and MC1R may influence human pigmentation phenotype
    Wojciech Branicki
    Institute of Forensic Research, Section of Forensic Genetics, Westerplatte 9, Krakow, Poland
    Ann Hum Genet 73:160-70. 2009
    ..Finally, using various approaches we were able to show that there is an interaction between MC1R and HERC2 in determination of skin and hair colour in the studied population sample...
  28. ncbi Eye colour: portals into pigmentation genes and ancestry
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Trends Genet 20:327-32. 2004
    ..These studies show that the OCA2 gene on chromosome 15 is the major determinant of brown and/or blue eye colour but also indicate that other loci will be involved in the broad range of hues seen in this trait in Europeans...
  29. pmc Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet
    C E Ooi
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 16:4508-18. 1997
    ..We report here that a defect in a gene encoding a putative coat adaptor protein leads to the eye color defect of garnet mutants...
  30. ncbi Melanin in human irides of different color and age of donors
    Albert R Wielgus
    Department of Biophysics, Faculty of Biotechnology, Jagiellonian University, ul Gronostajowa 7, 30 387 Krakow, Poland
    Pigment Cell Res 18:454-64. 2005
    ..Although some differences in the structure of eumelanin present in the human and bovine irides are possible, the results obtained in this study suggest that human irides contain eumelanin with very similar chemical properties...
  31. pmc The multicentre south European study 'Helios'. I: Skin characteristics and sunburns in basal cell and squamous cell carcinomas of the skin
    R Zanetti
    , Escuela Andaluza de Salud Publica, Spain
    Br J Cancer 73:1440-6. 1996
    ..Nevertheless, its association with BCC suggests, by analogy with melanoma, a relationship with intense sun exposure. Conversely, SCC would require prolonged exposure to sunlight...
  32. doi Developmental validation of the IrisPlex system: determination of blue and brown iris colour for forensic intelligence
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, Zuid Holland, The Netherlands
    Forensic Sci Int Genet 5:464-71. 2011
    ....
  33. ncbi Unique morphology of the human eye and its adaptive meaning: comparative studies on external morphology of the primate eye
    H Kobayashi
    Biological Laboratory, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, c o Faculty of Science, 12 1, O okayama 2 chome, Meguro ku, Tokyo, 152 8551, Japan
    J Hum Evol 40:419-35. 2001
    ..The uniqueness of human eye morphology among primates illustrates the remarkable difference between human and other primates in the ability to communicate using gaze signals...
  34. ncbi Preliminary study on eye colour in Japanese macaques (Macaca fuscata) in their natural habitat
    Peng Zhang
    Primate Research Institute, Kyoto University, Inuyama, Aichi 484 8506, Japan
    Primates 48:122-9. 2007
    ..Eye colour variation of Japanese macaques was discussed in relation to those of humans and rhesus macaques. A possible evolutionary model of eye colour in Japanese macaques was discussed...
  35. ncbi Interactive effects of MC1R and OCA2 on melanoma risk phenotypes
    David L Duffy
    Queensland Insititute of Medical Research, Brisbane, Australia
    Hum Mol Genet 13:447-61. 2004
    ..1 and 10.8%, respectively. To assess the interaction of the brown eye color gene OCA2 on the phenotypic effects of variant MC1R alleles we included eye color as a covariate, and also ..
  36. ncbi Does a pleiotropic gene explain deafness and blue irises in white cats?
    Caroline A Geigy
    Institute of Animal Genetics, Nutrition and Housing, Vetsuisse Faculty of the University of Berne, Switzerland
    Vet J 173:548-53. 2007
    ..The high heritability coefficients for both traits, 0.55 and 0.75 respectively, indicate that beside the major gene there is an important influence of polygenic effects...
  37. pmc A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
    Vanja Kastelic
    National Forensic Laboratory, General Police Directorate, Police, Ministry of the Interior, Vodovodna 95, Ljubljana, Slovenia
    Croat Med J 53:401-8. 2012
    ..To analyze two phenotype characteristics--eye and hair color--using single-nucleotide polymorphisms (SNPs) and evaluate their prediction accuracy in Slovenian population...
  38. ncbi High levels of melanin-related metabolites in plasma from pink-eyed dilution mice
    Kazumasa Wakamatsu
    Pigment Cell Res 20:222-4. 2007
  39. doi Technical note: quantitative measures of iris color using high resolution photographs
    Melissa Edwards
    Department of Anthropology, University of Toronto Mississauga, Ontario, Canada
    Am J Phys Anthropol 147:141-9. 2012
    ..This is partly related to difficulties associated with obtaining quantitative measurements of eye color. Here we introduce a new automated method for measuring iris color using high resolution photographs...
  40. doi Gene-gene interactions contribute to eye colour variation in humans
    Ewelina Pośpiech
    Section of Forensic Genetics, Institute of Forensic Research, Krakow, Poland
    J Hum Genet 56:447-55. 2011
    ....
  41. pmc The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains
    M H Brilliant
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Genetics 138:203-11. 1994
    ..129(21M), and may account for the enhanced Myod1 activity observed in SJL/J mice...
  42. ncbi Blue eyes in lemurs and humans: same phenotype, different genetic mechanism
    Brenda J Bradley
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Am J Phys Anthropol 139:269-73. 2009
    ..Recent work on humans indicates that blue eye color is associated with, and likely caused by, a single nucleotide polymorphism (rs12913832) in an intron of the gene ..
  43. ncbi Transient expression of the Drosophila melanogaster cinnabar gene rescues eye color in the white eye (WE) strain of Aedes aegypti
    A J Cornel
    Department of Biological Sciences, Galvin Life Sciences, University of Notre Dame, IN 46556, USA
    Insect Biochem Mol Biol 27:993-7. 1997
    ..Partial restoration of eye color (orange to red phenotype) in pupae and adults occurred in both sexes when first or second instar larvae were ..
  44. ncbi Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation
    Justin Graf
    Cooperative Research Centre for Diagnostics, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
    Hum Mutat 25:278-84. 2005
    ..polymorphisms (SNPs) in the MATP gene to determine if they are associated with normal human skin, hair, and eye color variation...
  45. pmc A polymorphism in the agouti signaling protein gene is associated with human pigmentation
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Am J Hum Genet 70:770-5. 2002
    ..This is the first report of an association of ASIP with specific human pigmentation characteristics. It remains to be investigated whether the interaction of MC1R and ASIP can enhance prediction of human pigmentation and melanoma risk...
  46. ncbi Multilocus OCA2 genotypes specify human iris colors
    Tony Frudakis
    DNAPrint Genomics, Inc, 1621 W University Pkwy, Sarasota, FL 34243, USA
    Hum Genet 122:311-26. 2007
    ....
  47. ncbi Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma
    Rotraut Mossner
    Department of Dermatology, Georg August University, von Siebold Strasse 3, 37075, Gottingen, Germany
    Arch Dermatol Res 298:371-9. 2007
    ..047). There was no effect of homozygous GST M1 or T1 deletions on melanoma risk. In contrast to previous data, there was no evidence that GSTM1 deficiency influences melanoma risk in the subgroup of individuals with red or blond hair...
  48. ncbi Eye color as an indicator of social rank in the fish Nile tilapia
    G L Volpato
    Research Center on Animal Welfare RECAW, Laborat rio de Fisiologia e Comportamento Animal, Departamento de Fisiologia, Instituto de Biociencias, Universidade Estadual Paulista, Botucatu, SP, Brasil
    Braz J Med Biol Res 36:1659-63. 2003
    We investigated the association of eye color with the dominant-subordinate relationship in the fish Nile tilapia, Oreochromis niloticus. Eye color pattern was also examined in relation to the intensity of attacks...
  49. ncbi P gene as an inherited biomarker of human eye color
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 11:782-4. 2002
    Human pigmentation, including eye color, has been associated with skin cancer risk...
  50. doi Eye color and the prediction of complex phenotypes from genotypes
    Fan Liu
    Curr Biol 19:R192-3. 2009
  51. ncbi Reproducibility of skin characteristic measurements and reported sun exposure history
    Stefano Rosso
    CPO Registro Tumori Piemonte, Turin, Italy
    Int J Epidemiol 31:439-46. 2002
    ..We also intended to use results from reproducibility analysis for correcting odds ratio (OR) estimates from the original study...
  52. ncbi The relationship between iris color, hair color, and skin sun sensitivity and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study
    Sandra C Tomany
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53726 2397, USA
    Ophthalmology 110:1526-33. 2003
    ..To examine the association between iris color, hair color, and skin sun sensitivity and the 10-year incidence of age-related maculopathy (ARM)...
  53. ncbi Importance of genetic effects for characteristics of the human iris
    Mats Larsson
    Department of Behavioral, Social and Legal Sciences, Center for Developmental Research, Orebro University, Sweden
    Twin Res 6:192-200. 2003
    ..The iris characteristics that showed the next highest additive-genetic effect were "contractional furrows" (78%) and "frequency of crypts" in the main stroma leaf (66%)...
  54. ncbi A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila
    E A Sevrioukov
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Mol Cell 4:479-86. 1999
    Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments...
  55. pmc Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster
    J A Birchler
    Division of Biological Sciences, University of Missouri, Columbia 65211
    Genetics 137:1057-70. 1994
    A locus is described in Drosophila melanogaster that modifies the expression of the white eye color gene. This trans-acting modifier reduces the expression of the white gene in the eye, but elevates the expression in other adult tissues...
  56. ncbi Assignment of genes coding for brown eye colour (BEY2) and brown hair colour (HCL3) on chromosome 15q
    H Eiberg
    University Institute of Medical Biochemistry and Genetics, Department of Medical Genetics, Danish Centre for Genome Research, Copenhagen, Denmark
    Eur J Hum Genet 4:237-41. 1996
    ..93; theta M = F = 0.10). The gene (DN10 or P) homologous to the pink-eye-dilution gene (p) in mice could be a candidate gene for BEY2 or for HCL3...
  57. pmc The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects
    R R Roseman
    Department of Biochemistry, University of Iowa, College of Medicine, Iowa City 52242
    EMBO J 12:435-42. 1993
    ..This separates enhancers and silencers distal to the su(Hw) binding region into an independent unit of gene activity, thereby causing their inactivation...
  58. ncbi Validation of the FAMACHA eye color chart for detecting clinical anemia in sheep and goats on farms in the southern United States
    R M Kaplan
    Department of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Vet Parasitol 123:105-20. 2004
    ..However, further studies are required to determine optimal strategies for incorporating FAMACHA-based selective treatment protocols into integrated nematode control programs...
  59. pmc Human matrix attachment regions are necessary for the establishment but not the maintenance of transgene insulation in Drosophila melanogaster
    Stephanie J Namciu
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 24:10236-45. 2004
    ..These observations are not compatible with the chromosomal loop model in its simplest form. Alternate mechanisms for MAR function in this system are proposed...
  60. ncbi Genetics of human iris colour and patterns
    Richard A Sturm
    Melanogenix Group, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
    Pigment Cell Melanoma Res 22:544-62. 2009
    ..Major candidate genes possibly effecting iris patterns are also discussed, including MITF and PAX6...
  61. ncbi A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15q
    Gu Zhu
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res 7:197-210. 2004
    We have rated eye color on a 3-point scale (1 = blue/grey, 2 = hazel/green, 3 = brown) in 502 twin families and carried out a 5-10 cM genome scan (400-757 markers)...
  62. ncbi Identification and characterisation of a silkworm ABC transporter gene homologous to Drosophila white
    E G Abraham
    Department of Insect Genetics and Breeding, National Institute of Sericultural and Entomological Sciences, Tsukuba, Ibaraki, Japan
    Mol Gen Genet 264:11-9. 2000
    ..The level of Bmwh3 mRNA was reduced in w3 and w3ol mutants but normal in other egg- and eye-colour mutants, suggesting that Bmwh3 correspond to the w3 locus. Genetic analysis was used to map the cloned gene to chromosome 10...
  63. ncbi Time trends of cutaneous melanoma in Queensland, Australia and Central Europe
    Mathieu Boniol
    Cancer 94:1902-3. 2002
  64. ncbi Cutaneous phenotype and MC1R variants as modifying factors for the development of melanoma in CDKN2A G101W mutation carriers from 4 countries
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Int J Cancer 121:825-31. 2007
    ..Cases also varied significantly for eye color, freckling, and nevi...
  65. ncbi Ambient UVB and melanoma risk in the United States: a case-control analysis
    C Suzanne Lea
    Department of Epidemiology and Public Health Biology, University of California, Berkeley, Berkeley, CA USA
    Ann Epidemiol 17:447-53. 2007
    ..This study assessed cumulative UVB using a ground-based measurement instrument to estimate the association between UVB and melanoma...
  66. ncbi Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients
    H Bu
    Division of Dermatology, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
    Oncol Rep 17:859-64. 2007
    ..GSTP1 GG genotype was more often found in the patients with brown and mixed eye color or brown and black hair than those with blue and green eyes or blond hair...
  67. ncbi Morphometric effects of long-term exposure to latanoprost
    Kathryn P B Cracknell
    St Paul s Unit of Ophthalmology, Department of Medicine, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Ophthalmology 114:938-48. 2007
    ..To investigate the morphological and melanin granule changes in irides after variable-term exposure to latanoprost, where the latanoprost-induced iris darkening (LIID) side effect has been identified and photographically recorded...
  68. ncbi Common melanocytic nevi in 7-year-old schoolchildren residing at different latitudes in Sweden
    Ylva Rodvall
    Department of Occupational and Environmental Health, Karolinska Institutet, Norrbacka 3rd floor, SE 171 76 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 16:122-7. 2007
    ..The purpose of this study was to investigate the number of CMN in relation to tanning habits and complexion among 7-year-old children residing at different latitudes in Sweden...
  69. ncbi Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes
    An Chi
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA
    J Proteome Res 5:3135-44. 2006
    ..The sharing of proteins between melanosomes and other lysosome-related organelles suggests a common evolutionary origin. This work represents a model for the study of the biogenesis of lysosome-related organelles...
  70. ncbi Phenotypical characteristics, lifestyle, social class and uveal melanoma
    Andreas Stang
    Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany
    Ophthalmic Epidemiol 10:293-302. 2003
    ..To investigate potential risk factors of uveal melanoma, including phenotypical characteristics, eye burns, social class, smoking and alcohol consumption...
  71. ncbi Risk factors for histological types and anatomic sites of cutaneous basal-cell carcinoma: an italian case-control study
    Claudio Pelucchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Invest Dermatol 127:935-44. 2007
    ..74 for truncal location. Direct associations were observed with recreational sunlight exposure, eye color, red hair, and number and early age of severe sunburn episodes, along with some differences in risk between ..
  72. pmc Anthropometric measures in relation to basal cell carcinoma: a longitudinal study
    Catherine M Olsen
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Cancer 6:82. 2006
    ....
  73. ncbi A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Epidemiol 35:756-64. 2006
    ..The use of a novel case-control design in which cases have second primaries and controls are cancer survivors has been proposed for this purpose...
  74. pmc Comparison of risk patterns in carcinoma and melanoma of the skin in men: a multi-centre case-case-control study
    R Zanetti
    CPO Registro Tumori Piemonte, via San Francesco da Paola 31, 10123 Turin, Italy
    Br J Cancer 94:743-51. 2006
    ..Factors influencing risk of SCC are different, with chronic exposure to sun playing a major role in causing this type of carcinoma...
  75. ncbi The association between host susceptibility factors and uveal melanoma: a meta-analysis
    Ezekiel Weis
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Arch Ophthalmol 124:54-60. 2006
    ..To conduct a meta-analysis, using observational studies, to examine the association between host susceptibility factors and uveal melanoma...
  76. ncbi Monte Carlo simulation of latanoprost induced iris darkening
    K P B Cracknell
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Comput Methods Programs Biomed 87:93-103. 2007
    ..The MC simulated colours were in good agreement with the in vivo photography of the eye colour. Hence, we have demonstrated that increases in melanin granule size causes iris darkening, and can explain LIID...
  77. ncbi Iridial pigmentation induced by latanoprost ophthalmic solution in Japanese glaucoma patients
    T Chiba
    Department of Ophthalmology, Yamanashi Medical University, Tamaho, Yamanashi, Japan
    J Glaucoma 10:406-10. 2001
    ..CONCLUSION: The incidence of iridial pigmentation by latanoprost ophthalmic solution in Japanese patients was higher than previously reported values in pigmented races...
  78. ncbi The mouse pink-eyed unstable mutation: a DNA duplication revealed by genome scanning
    M H Brilliant
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Pigment Cell Res . 1992
  79. pmc Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations
    K J Moore
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 125:421-30. 1990
    ..Unexpectedly, dsu suppressed the ruby eye color of ruby-eye (ru) and ruby-eye-2 (ru-2) mice, to black...
  80. ncbi Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences
    E Steingrimsson
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702
    Nat Genet 8:256-63. 1994
    ..These molecular data, combined with the extensive body of genetic data accumulated for murine mi, shed light on the phenotypic and developmental consequences of mi mutations and offer a mouse model for WS2...
  81. ncbi Main pigmentary features and melanocortin 1 receptor (MC1R) gene polymorphisms in the population of the Canary Islands
    Ricardo F de-Misa
    Dermatology Department, Research Unit, Medical Oncology Department, Nuestra Señora de Candelaria University Hospital and Gerencia de Atención Primaria, Santa Cruz de Tenerife, Spain
    Int J Dermatol 47:806-11. 2008
    ..The Canary Islands have a sunny and temperate climate, but data regarding the phenotypic and genotypic risk factors among the population are lacking...
  82. doi Shedding light on skin cancer
    Paul D P Pharoah
    Nat Genet 40:817-8. 2008
  83. ncbi Distribution of congenital melanocytic naevi and congenital naevus-like naevi in a survey of 3406 Italian schoolchildren
    S Gallus
    Centro Studi GISED, USC di Dermatologia, Ospedali Riuniti di Bergamo, Largo Barozzi 1, 24100 Bergamo, Italy
    Br J Dermatol 159:433-8. 2008
    ..Scanty information is available on the prevalence of congenital melanocytic naevi (CMN) and congenital naevus-like naevi (CNLN), particularly the small ones...
  84. doi Nevus depigmentosus affecting the iris and skin: a case report
    P Sharma
    J Eur Acad Dermatol Venereol 22:634-5. 2008
  85. doi Predicting tooth color from facial features and gender: results from a white elderly cohort
    Alexander J Hassel
    Department of Prosthodontics, University of Heidelberg, Heidelberg, Germany
    J Prosthet Dent 99:101-6. 2008
    ..Clinicians providing edentulous patients with complete dentures are often confronted with the problem of not knowing the patient's natural tooth color. It would be valuable to be able to determine this from other facial features...
  86. ncbi Post-peripheral iridotomy inflammation in patients with dark pigmentation
    Ghada A Siam
    Glaucoma Service Department, Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USA
    Ophthalmic Surg Lasers Imaging 39:49-53. 2008
    ..These cases were possibly predisposed to this reaction by the heavy pigmentation of their irides based on race, their use of latanoprost, or the conjunction of these factors...
  87. doi Iris morphology
    Miguel A Teus
    Ophthalmology 115:418-9; author reply 419-20. 2008
  88. ncbi The clinical impact and incidence of periocular pigmentation associated with either latanoprost or bimatoprost therapy
    Elizabeth D Sharpe
    Glaucoma Consultants and Center For Eye Research, Mount Pleasant, South Carolina, USA
    Curr Eye Res 32:1037-43. 2007
    ..To evaluate the incidence and characteristics of periocular pigmentation with latanoprost versus bimatoprost...
  89. pmc UV radiation exposure, skin type and lymphoid malignancies: results of a French case-control study
    L Grandin
    INSERM U754, 16 Avenue Paul Vaillant Couturier, Villejuif, France
    Cancer Causes Control 19:305-15. 2008
    ..Investigating the relationship between skin type, UV exposure, and lymphoid malignancies (LM)...
  90. ncbi Does a high UV environment ensure adequate vitamin D status?
    Michael Kimlin
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
    J Photochem Photobiol B 89:139-47. 2007
    ..No associations were found between 25(OH)D status and age, gender, smoking status, or the use of sunscreen...
  91. ncbi Sun exposure, phenotypic characteristics, and cutaneous malignant melanoma. An analysis according to different clinico-pathological variants and anatomic locations (Italy)
    Luigi Naldi
    Clinica Dermatologica, Ospedali Riuniti di Bergamo, Universita degli Studi di Milano Bicocca, Bergamo, Italy
    Cancer Causes Control 16:893-9. 2005
    ..The aim of the study was to examine the relation between sun exposure and other selected risk factors and the development of different clinico-pathological variants of cutaneous malignant melanoma (CMM) at different body locations...
  92. ncbi Induction and characterization of mutations at the b locus of the medaka, Oryzias latipes
    Atsuko Shimada
    Department of Biological Sciences, School of Science, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Zoolog Sci 19:411-7. 2002
    ..We speculate that the bv, B', bd, bdl1, and b alleles might arise by the mutations in the regulatory region for skin melanogenesis...
  93. ncbi Case-control study to identify melanoma risk factors in the Belgian population: the significance of clinical examination
    T Nijsten
    Department of Dermatology, University Hospital Antwerp, Wilrijkstraat 10, B Julien Lambert 2650 Edegem, Belgium
    J Eur Acad Dermatol Venereol 19:332-9. 2005
    ..Although numerous studies have evaluated risk factors associated with cutaneous malignant melanoma (CMM), no such study has been carried out in Belgium...
  94. ncbi Determinants of skin sensitivity to solar irradiation
    W M R Broekmans
    TNO Nutrition and Food Research, Zeist, Netherlands
    Eur J Clin Nutr 57:1222-9. 2003
    ..Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer...
  95. ncbi Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation
    Gui Lin Zhan
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Glaucoma 12:383-9. 2003
    ..Unoprostone isopropyl ester (unoprostone) -induced iris color darkening was evaluated in a rabbit model using a cyclooxygenase inhibitor, an alpha(1)-adrenergic antagonist, and sympathetic denervation...
  96. ncbi Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%
    Bernard E McCarey
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Ophthalmology 111:1480-8. 2004
    ..To assess whether iris color and eyelash changes occur with the use of unoprostone for 2 years...
  97. ncbi A prospective study of pigmentation, sun exposure, and risk of cutaneous malignant melanoma in women
    Marit Bragelien Veierød
    Section of Medical Statistics, University of Oslo, Oslo, Norway
    J Natl Cancer Inst 95:1530-8. 2003
    ..Here we report the first results from a large prospective cohort study of pigmentation factors and sun exposure in relation to melanoma risk...
  98. ncbi The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    Pigment Cell Res 16:266-72. 2003
    ..To assess the interaction of the brown eye color gene BEY2/OCA2 on the phenotypic effects of variant MC1R alleles we imputed OCA2 genotype in the twin collection...
  99. ncbi Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation
    Dhaval Bodiwala
    Department of Urology, North Staffordshire Hospital, Staffordshire, UK
    Cancer Lett 200:141-8. 2003
    ..0) and 40.2% men with high scores (>8.0) had cancer. These subgroups were stratified by childhood sunburning, holidays in a hot climate and skin type such that subgroups with a 13.0-fold increased risk of cancer were identified...
  100. ncbi A 5-year, multicenter, open-label, safety study of adjunctive latanoprost therapy for glaucoma
    Albert Alm
    Department of Neuroscience, Ophthalmology, University Hospital, Uppsala, Sweden
    Arch Ophthalmol 122:957-65. 2004
    ..To evaluate the 5-year safety and efficacy of adjunctive 0.005% latanoprost once daily...
  101. ncbi A standardized approach for iris color determination
    Birgit Niggemann
    Covance Laboratories GmbH, Munster, Germany
    Int J Toxicol 22:49-51. 2003
    ..This method provides a fast and accurate way to quantify color changes in the iris of both experimental animals and clinical trials...

Research Grants98

  1. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2009
    ....
  2. Quantification of the environmental UVA exposure
    Michael Kimlin; Fiscal Year: 2004
    ..abstract_text> ..
  3. Quantification of the environmental UVA exposure
    Michael Kimlin; Fiscal Year: 2005
    ..abstract_text> ..
  4. Quantification of the environmental UVA exposure
    Michael Kimlin; Fiscal Year: 2007
    ..abstract_text> ..
  5. Quantification of the environmental UVA exposure
    Michael Kimlin; Fiscal Year: 2008
    ..abstract_text> ..
  6. Quantification of the environmental UVA exposure
    Michael Kimlin; Fiscal Year: 2006
    ..abstract_text> ..
  7. VERGENCE & OCULAR ACCOMMODATION--ROLE OF THE CEREBELLUM
    PAUL GAMLIN; Fiscal Year: 1991
    ..More detailed knowledge of this nature of the central neural processing of vergence and accommodative eye movements should aid in our understanding of strabismus, disorders of binocular vision, and accommodative dysfunction...
  8. Assay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1
    Michael Rogers; Fiscal Year: 2007
    ..They may also be useful in treating toxicity associated with anthrax infection. [unreadable]..
  9. Prophytactic surgery in carriers of BRCA 1/2 mutations
    Timothy Rebbeck; Fiscal Year: 2007
    ..These studies will motivate future studies of BRCA1/2-associated breast tumor biology, prevention, and treatment. [unreadable] [unreadable]..
  10. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2007
    ....
  11. Minicomputer Upgrade for the Clinical Resarch Database
    Colin Begg; Fiscal Year: 2002
    ..This proposal is a request for funds to upgrade the hardware platform once again to maintain the performance of the system in the face of these rapidly increasing demands. ..
  12. PROPHYLACTIC SURGERY IN CARRIERS OF BRCA1 AND BRCA2
    Timothy Rebbeck; Fiscal Year: 2002
    ..This proposal will address that immediate and important clinical need. ..
  13. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2002
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  14. Pharmacogenetic Epidemiology of Birth Defects and Cancer
    Timothy Rebbeck; Fiscal Year: 2004
    ....
  15. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2007
    ....
  16. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    Michael Rogers; Fiscal Year: 2009
    ..g. macular degeneration, diabetic retinopathy, retinopathy of prematurity, cancer, cardiovascular disease, arthritis, etc.). ..
  17. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2010
    ..g. macular degeneration, diabetic retinopathy, retinopathy of prematurity, cancer, cardiovascular disease, arthritis, etc.). ..
  18. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    Michael Rogers; Fiscal Year: 2008
    ..g. macular degeneration, diabetic retinopathy, retinopathy of prematurity, cancer, cardiovascular disease, arthritis, etc.). ..
  19. Novel Angiogenesis Inhibitors Targeting the Anthrax Toxin Receptors
    MICHAEL SEAN ROGERS; Fiscal Year: 2010
    ..g. macular degeneration, diabetic retinopathy, retinopathy of prematurity, cancer, cardiovascular disease, arthritis, etc.). ..
  20. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2005
    ....
  21. Ethnic difference in prostate cancer
    Timothy Rebbeck; Fiscal Year: 2009
    ....
  22. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2010
    ....
  23. Subcortical Luminance Pathways
    PAUL GAMLIN; Fiscal Year: 2005
    ..Finally, beside their roles in pupil control and circadian rhythms, these ganglion cells project to the lateral geniculate nucleus and are likely to have very broad-reaching effect on other human visual behaviors. ..
  24. MELANOMA AND ALLELIC VARIATION IN THE MCIR GENE
    Peter Kanetsky; Fiscal Year: 2005
    ..Result from this project may provide valuable insight into the genetic predisposition to melanoma seen in some families, and may lead to more efficient mechanisms of primary prevention and clinical follow-up within these families. ..
  25. Identification of Lens Development Genes
    Thomas Vihtelic; Fiscal Year: 2005
    ..The characterization of the molecular phenotype and determination of the underlying arl gene defect will lead to the identification of candidate genes in humans causing anterior segment dysgenesis and cataracts. ..
  26. Molecular Predictive Testing in Ocular Melanoma
    JAMES HARBOUR; Fiscal Year: 2008
    ....
  27. PROPHYLACTIC SURGERY IN CARRIERS OF BRCA1 AND BRCA2
    Timothy Rebbeck; Fiscal Year: 2004
    ..This proposal will address that immediate and important clinical need. ..
  28. Epidemiologic Parameters of Rare Cancer Risk Factors
    Colin Begg; Fiscal Year: 2004
    ..All of these aims are motivated by an international study of the genetic epidemiology of melanoma that is currently in progress. ..
  29. Subcortical Luminance Pathways
    PAUL GAMLIN; Fiscal Year: 2004
    ..Finally, beside their roles in pupil control and circadian rhythms, these ganglion cells project to the lateral geniculate nucleus and are likely to have very broad-reaching effect on other human visual behaviors. ..
  30. Identification of Lens Development Genes
    Thomas Vihtelic; Fiscal Year: 2004
    ..The characterization of the molecular phenotype and determination of the underlying arl gene defect will lead to the identification of candidate genes in humans causing anterior segment dysgenesis and cataracts. ..
  31. Molecular Biology of Retinoblastoma
    Daniel Albert; Fiscal Year: 2005
    ..Lastly the potency of the 19-nor compounds wil be compared to standard chemotherapy and their possible synergistic effect in multi-drug treatment established. ..
  32. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2006
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. [unreadable] [unreadable]..
  33. Genetic and genomic tools for the emerging model organsism, Nasonia
    John Werren; Fiscal Year: 2008
    ..It has the strong support of the Nasonia and other relevant research communities. ..
  34. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
    ....
  35. Statistical Methods for Identifying Clonal Tumors
    Colin Begg; Fiscal Year: 2009
    ....
  36. Ethnic difference in prostate cancer
    Timothy Rebbeck; Fiscal Year: 2007
    ....
  37. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
  38. Determinants of Disparity in Prostate Cancer Outcomes
    Timothy Rebbeck; Fiscal Year: 2007
    ..abstract_text> ..
  39. COLLABORATIVE OBSERVATIONAL STUDY OF MYOPIA IN COMET CHILDREN
    Ruth Manny; Fiscal Year: 2007
    ..In addition to UHCO, the other clinical centers are located at Colleges of Optometry in Boston, Birmingham, and Philadelphia, with the Study Chair in Boston and the Coordinating Center at Stony Brook NY. ..
  40. Identification of Lens Development Genes
    Thomas Vihtelic; Fiscal Year: 2007
    ..The characterization of the molecular phenotype and determination of the underlying arl gene defect will lead to the identification of candidate genes in humans causing anterior segment dysgenesis and cataracts. ..
  41. Prophytactic surgery in carriers of BRCA 1/2 mutations
    Timothy Rebbeck; Fiscal Year: 2006
    ..These studies will motivate future studies of BRCA1/2-associated breast tumor biology, prevention, and treatment. [unreadable] [unreadable]..
  42. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
    ....
  43. Molecular Biology of Retinoblastoma
    Daniel Albert; Fiscal Year: 2006
    ..Lastly the potency of the 19-nor compounds wil be compared to standard chemotherapy and their possible synergistic effect in multi-drug treatment established. ..
  44. Subcortical Luminance Pathways
    PAUL GAMLIN; Fiscal Year: 2006
    ..Finally, beside their roles in pupil control and circadian rhythms, these ganglion cells project to the lateral geniculate nucleus and are likely to have very broad-reaching effect on other human visual behaviors. ..
  45. Epidemiologic Parameters of Rare Cancer Risk Factors
    Colin Begg; Fiscal Year: 2005
    ..All of these aims are motivated by an international study of the genetic epidemiology of melanoma that is currently in progress. ..
  46. VERGENCE & OCULAR ACCOMMODATION--ROLE OF THE CEREBELLUM
    PAUL GAMLIN; Fiscal Year: 1992
    ..More detailed knowledge of this nature of the central neural processing of vergence and accommodative eye movements should aid in our understanding of strabismus, disorders of binocular vision, and accommodative dysfunction...
  47. NEURAL CONTROL OF THE PUPIL
    PAUL GAMLIN; Fiscal Year: 1992
    ..The relationship between their firing rate and pupillary diameter will be studied. In addition, it will be determined if the pupillomotor neurons in EW mediate both the PLR and the pupillary near response or if they mediate only the PLR...
  48. NEURAL CONTROL OF THE PUPIL
    PAUL GAMLIN; Fiscal Year: 1993
    ..The relationship between their firing rate and pupillary diameter will be studied. In addition, it will be determined if the pupillomotor neurons in EW mediate both the PLR and the pupillary near response or if they mediate only the PLR...
  49. MOLECULAR BIOLOGY OF RETINOBLASTOMA AND UVEAL MELANOMA
    Daniel Albert; Fiscal Year: 1999
    ..5. We will characterize pigmented tumors developing in the eyes of mice expressing SV40-T antigen (SV40-Tag) under the control of the mouse tyrosinase gene, and establish the relevance of these mice as a model for human uveal melanoma. ..
  50. NEURAL CONTROL OF THE PUPIL
    PAUL GAMLIN; Fiscal Year: 2000
    ..We will also use anatomical and electrophysiological techniques to investigate projections from the prelunate gyrus and other extrastriate visual areas to the pretectal olivary nucleus. ..
  51. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2000
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  52. MOLECULAR BIOLOGY OF RETINOBLASTOMA AND UYEAL MELANOMA
    Daniel Albert; Fiscal Year: 1993
    ..In addition we have described the inhibition of retinoblastoma growth by vitamin D compounds and sodium butyrate and we will continue to study potential therapeutic strategies in the transgenic mouse model of retinoblastoma...
  53. ATYPICAL NEVI IN MELANOMA--A CASE-CONTROL STUDY
    Linda Titus Ernstoff; Fiscal Year: 2000
    ..The ability to self-diagnose atypical nevi has important implications for melanoma prevention. ..
  54. NEURAL CONTROL OF VERGENCE AND OCULAR ACCOMMODATION
    PAUL GAMLIN; Fiscal Year: 2000
    ....
  55. MOLECULAR BIOLOGY OF RETINOBLASTOMA AND UVEAL MELANOMA
    Daniel Albert; Fiscal Year: 2000
    ..5. We will characterize pigmented tumors developing in the eyes of mice expressing SV40-T antigen (SV40-Tag) under the control of the mouse tyrosinase gene, and establish the relevance of these mice as a model for human uveal melanoma. ..
  56. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2001
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  57. Development of Wild-Type and Mutant Zebrafish Lens
    Thomas Vihtelic; Fiscal Year: 2003
    ..The characterization of the molecular phenotype and determination of the underlying arl gene defect will lead to the identification of candidate genes in humans causing anterior segment dysgenesis and cataracts. ..
  58. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2001
    ..abstract_text> ..
  59. NEURAL CONTROL OF VERGENCE AND OCULAR ACCOMMODATION
    PAUL GAMLIN; Fiscal Year: 2001
    ....
  60. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2001
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  61. ATYPICAL NEVI IN MELANOMA--A CASE-CONTROL STUDY
    Linda Titus Ernstoff; Fiscal Year: 2001
    ..The ability to self-diagnose atypical nevi has important implications for melanoma prevention. ..
  62. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2002
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  63. Epidemiologic Parameters of Rare Cancer Risk Factors
    Colin Begg; Fiscal Year: 2003
    ..All of these aims are motivated by an international study of the genetic epidemiology of melanoma that is currently in progress. ..
  64. CORRECTION OF MYOPIA TRIAL--CLINICAL CENTER
    Ruth Manny; Fiscal Year: 2002
    ..In addition to UHCO, the other clinical centers are located at Colleges of Optometry in Boston, Birmingham, and Philadelphia, with the Study Chair in Boston and the Coordinating Center at Stony Brook NY. ..
  65. COMBINED VISUAL DISPLAY & EYE TRACKING SYSTEM FOR HIGH FIELD FMRI STUDIES
    PAUL GAMLIN; Fiscal Year: 2000
    ..This research may result in a better understanding of the brain pathways involved in phonological access for speech production and for word recognition, and may contribute to a better understanding of language development and disorders. ..
  66. Ethnic difference in prostate cancer
    Timothy Rebbeck; Fiscal Year: 2008
    ....
  67. THE MOLECULAR BIOLOGY OF RETINOBLASTOMA
    Daniel Albert; Fiscal Year: 2003
    ..2d) Determine whether I a-hydroxy-D2 and 16,23 -D3 inhibit angiogenesis in a transgenic mouse model. These studies will complete the pre-clinical investigation of the efficacy of vitamin D analogs for human treatment. ..
  68. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2008
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
  69. Ethnic difference in prostate cancer
    Timothy Rebbeck; Fiscal Year: 2009
    ....
  70. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Mark Sherwood; Fiscal Year: 2003
    ....
  71. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2003
    ..abstract_text> ..
  72. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2003
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  73. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2002
    ..abstract_text> ..
  74. COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
    Mark Sherwood; Fiscal Year: 2002
    ....
  75. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 2000
    ..This information could then be used to more effectively apply prostate cancer prevention and control strategies. ..
  76. PROPHYLACTIC SURGERY IN CARRIERS OF BRCA1 AND BRCA2
    Timothy Rebbeck; Fiscal Year: 2001
    ..This proposal will address that immediate and important clinical need. ..
  77. Prophytactic surgery in carriers of BRCA 1/2 mutations
    Timothy Rebbeck; Fiscal Year: 2005
    ..These studies will motivate future studies of BRCA1/2-associated breast tumor biology, prevention, and treatment. ..
  78. Melanoma Pathogenesis
    Linda Titus Ernstoff; Fiscal Year: 2006
    ..e., slide preparation) of pathology specimens, and the refinement of laboratory techniques for analyzing chromosome 9p21 alterations. [unreadable] [unreadable]..
  79. THE MOLECULAR BIOLOGY OF RETINOBLASTOMA
    Daniel Albert; Fiscal Year: 2001
    ..2d) Determine whether I a-hydroxy-D2 and 16,23 -D3 inhibit angiogenesis in a transgenic mouse model. These studies will complete the pre-clinical investigation of the efficacy of vitamin D analogs for human treatment. ..
  80. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2007
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. [unreadable] [unreadable]..
  81. ATYPICAL NEVI IN MELANOMA--A CASE-CONTROL STUDY
    Linda Titus Ernstoff; Fiscal Year: 1999
    ..The ability to self-diagnose atypical nevi has important implications for melanoma prevention. ..