body temperature


Top Publications

  1. ncbi Effects of size and temperature on metabolic rate
    J F Gillooly
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
    Science 293:2248-51. 2001
  2. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
  3. pmc Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators
    Camille Saini
    Department of Molecular Biology, National Centers of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    Genes Dev 26:567-80. 2012
  4. ncbi Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature
    Hannah V Carey
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Physiol Rev 83:1153-81. 2003
  5. ncbi Rhythms of mammalian body temperature can sustain peripheral circadian clocks
    Steven A Brown
    Department of Molecular Biology, University of Geneva, Sciences II, 30, Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
    Curr Biol 12:1574-83. 2002
  6. ncbi Towards a molecular understanding of adaptive thermogenesis
    B B Lowell
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 404:652-60. 2000
  7. ncbi Hyperthermia and central fatigue during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2200 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 91:1055-60. 2001
  8. pmc Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
    Colm Cunningham
    Department of Biochemistry, Trinity College Institute of Neuroscience, Trinity College Dublin, Republic of Ireland
    Biol Psychiatry 65:304-12. 2009
  9. ncbi Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats
    S Bhatnagar
    Department of Anaesthesiology, Abranson Building Ste 402, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Neuroendocrinol 18:13-24. 2006
  10. pmc Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    Andreea Soare
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Aging (Albany NY) 3:374-9. 2011

Detail Information

Publications280 found, 100 shown here

  1. ncbi Effects of size and temperature on metabolic rate
    J F Gillooly
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
    Science 293:2248-51. 2001
    ..Temperature and body size are primary determinants of biological time and ecological roles...
  2. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
    ..Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues...
  3. pmc Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators
    Camille Saini
    Department of Molecular Biology, National Centers of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    Genes Dev 26:567-80. 2012
    ..Here, we investigated the role of daily body temperature fluctuations as possible systemic cues in the resetting of peripheral oscillators...
  4. ncbi Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature
    Hannah V Carey
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Physiol Rev 83:1153-81. 2003
    ..The hibernation season is characterized by extended bouts of torpor, during which minimal body temperature (Tb) can fall as low as -2.9 degrees C and metabolism can be reduced to 1% of euthermic rates...
  5. ncbi Rhythms of mammalian body temperature can sustain peripheral circadian clocks
    Steven A Brown
    Department of Molecular Biology, University of Geneva, Sciences II, 30, Quai Ernest Ansermet, CH 1211 Geneva, Switzerland
    Curr Biol 12:1574-83. 2002
    ..Because mammalian body temperature is subject to circadian variations of 1 degrees C-4 degrees C, we wished to determine whether these ..
  6. ncbi Towards a molecular understanding of adaptive thermogenesis
    B B Lowell
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 404:652-60. 2000
    ..Here we explore these developments in relation to classical physiological views of adaptive thermogenesis...
  7. ncbi Hyperthermia and central fatigue during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2200 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 91:1055-60. 2001
    ..In conclusion, these data demonstrate that the ability to generate force during a prolonged MVC is attenuated with hyperthermia, and the impaired performance is associated with a reduction in the voluntary activation percentage...
  8. pmc Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
    Colm Cunningham
    Department of Biochemistry, Trinity College Institute of Neuroscience, Trinity College Dublin, Republic of Ireland
    Biol Psychiatry 65:304-12. 2009
  9. ncbi Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats
    S Bhatnagar
    Department of Anaesthesiology, Abranson Building Ste 402, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Neuroendocrinol 18:13-24. 2006
    These present studies aimed to compare changes in hypothalamic-pituitary-adrenal (HPA) activity and body temperature in response to acute social defeat, to repeated social stress and to novel restraint after repeated stress, as well as to ..
  10. pmc Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    Andreea Soare
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Aging (Albany NY) 3:374-9. 2011
    Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons...
  11. ncbi Measurement of brain temperature with magnetic resonance spectroscopy in acute ischemic stroke
    Bartosz Karaszewski
    Department of Neurology of Adults, Medical University of Gdansk, Gdansk, Poland
    Ann Neurol 60:438-46. 2006
    ..We used magnetic resonance spectroscopic imaging (water-to-N-acetylaspartate frequency shift) to measure cerebral temperature noninvasively in stroke patients...
  12. ncbi Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
    ..To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice...
  13. ncbi Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals
    Thomas Arendt
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Neurosci 23:6972-81. 2003
    ..Hibernation will, therefore, be a valuable model to study the regulation of PHF-like tau-phosphorylation and its cell biological sequelae under physiological in vivo conditions...
  14. pmc A phase response curve to single bright light pulses in human subjects
    Sat Bir S Khalsa
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 549:945-52. 2003
    ..02 h. Phase delays occurred when the light stimulus was centred prior to the critical phase at the core body temperature minimum, phase advances occurred when the light stimulus was centred after the critical phase, and no phase ..
  15. ncbi Emerging disease of amphibians cured by elevated body temperature
    Douglas C Woodhams
    School of Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia
    Dis Aquat Organ 55:65-7. 2003
  16. pmc Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature
    Vibhor Kumar
    Department of Biomedical Engineering and Computational Science, School of Science and Technology, Centre of Excellence in Computational Complex Systems Research, Aalto University Aalto, Finland
    PLoS ONE 6:e18841. 2011
    ..The shape of native LDL particles and the conformation of native apoB-100 on the particles remain incompletely characterized at the physiological human body temperature (37 °C).
  17. ncbi betaAR signaling required for diet-induced thermogenesis and obesity resistance
    Eric S Bachman
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 297:843-5. 2002
    ..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity...
  18. ncbi Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design
    Niklas Nielsen
    Department of Anesthesia and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden
    Am Heart J 163:541-8. 2012
    ..Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known...
  19. pmc Core body temperature during competition in the heat: National Boys' 14s Junior Championships
    Michael F Bergeron
    Environmental Physiology Laboratory, Medical College of Georgia, Augusta, Georgia 30912, USA
    Br J Sports Med 41:779-83. 2007
    To examine on-court core body temperature (T(C)) and sweat loss, as well as pre- and post-play hydration status, in elite adolescent tennis players during a national championships event in a hot climate.
  20. pmc Microsatellite mapping of QTL affecting growth, feed consumption, egg production, tonic immobility and body temperature of Japanese quail
    Francis Minvielle
    Génétique et Diversité Animales, Institut National de la Recherche Agronomique, Centre de Jouy, 78352 Jouy en Josas, France
    BMC Genomics 6:87. 2005
  21. ncbi Effect of restraint and injection methods on heart rate and body temperature in mice
    M K Meijer
    Department of Animals, Science and Society, Utrecht University, Utrecht, The Netherlands
    Lab Anim 40:382-91. 2006 gain more insight into quantifying this acute stress by means of the parameters heart rate (HR) and body temperature (BT), we subjected mice to different restraint and injection methods...
  22. ncbi Prenatal exposure to elevated maternal body temperature and risk of epilepsy in childhood: a population-based pregnancy cohort study
    Yuelian Sun
    Department of Epidemiology, University of Aarhus, Aarhus, Denmark
    Paediatr Perinat Epidemiol 25:53-9. 2011
    Elevated maternal body temperature during pregnancy is of clinical concern as side effects have been reported. We estimated the association between maternal fever and sauna bathing during pregnancy and risk of epilepsy in the offspring...
  23. ncbi Inverse relationship of baseline body temperature and outcome between ischemic stroke patients treated and not treated with thrombolysis: the Bergen stroke study
    Halvor Naess
    Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Acta Neurol Scand 122:414-7. 2010
    High body temperature may promote clot lysis whereas low body temperature is neuroprotective in patients with cerebral infarction...
  24. ncbi Maximal heat dissipation capacity and hyperthermia risk: neglected key factors in the ecology of endotherms
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue 2, Aberdeen, Scotland, UK
    J Anim Ecol 79:726-46. 2010
  25. ncbi Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
    Jun Chen
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Pain 152:1165-72. 2011
    Despite the increasing interest in TRPA1 channel as a pain target, its role in cold sensation and body temperature regulation is not clear; the efficacy and particularly side effects resulting from channel blockade remain poorly ..
  26. pmc Impact of the human circadian system, exercise, and their interaction on cardiovascular function
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20541-6. 2010
  27. pmc Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor
    Matthew T Andrews
    Department of Biology, University of Minnesota Duluth, Duluth, Minnesota 1035 Kirby Dr, Duluth, MN 55812, USA
    Am J Physiol Regul Integr Comp Physiol 296:R383-93. 2009
    ..We show that BHB and glucose enter the heart and brain under conditions of depressed body temperature and heart rate but that their utilization as a fuel is highly selective...
  28. ncbi Hibernation in black bears: independence of metabolic suppression from body temperature
    Øivind Tøien
    Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775, USA
    Science 331:906-9. 2011
    ..We measured metabolic rate and body temperature in hibernating black bears and found that they suppress metabolism to 25% of basal rates while regulating ..
  29. pmc Permeability of the blood-brain barrier depends on brain temperature
    E A Kiyatkin
    Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Neuroscience 161:926-39. 2009
    ..Therefore, brain temperature per se is an important factor in regulating BBB permeability, alterations in brain water homeostasis, and subsequent structural abnormalities of brain cells...
  30. pmc The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation
    Jens T Stieler
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e14530. 2011
    ..hibernation characteristics of black bears with a continuous torpor period and an only slightly decreased body temperature, therefore, potentially reflects the limitations of this adaptive reaction pattern and, thus, might indicate ..
  31. ncbi Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise
    Jonathan Peake
    School of Human Movement Studies, University of Queensland, Brisbane, QLD, 4072, Australia
    Eur J Appl Physiol 102:391-401. 2008
  32. ncbi Body temperature modulates the antioxidant and acute immune responses to exercise
    Antonia Mestre-Alfaro
    Laboratory of Physical Activity Science, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain
    Free Radic Res 46:799-808. 2012
    ..In conclusion, the increased core body temperature results in the acute phase immune response associated to intense exercise and in the immune cell adaptations ..
  33. pmc Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature
    M Camila Almeida
    Systemic Inflammation Laboratory FeverLab, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 32:2086-99. 2012
    ..In vivo, M8-B decreased deep body temperature (T(b)) in Trpm8(+/+) mice and rats, but not in Trpm8(-/-) mice, thus suggesting an on-target action...
  34. pmc Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors
    Tulasi R Jinka
    Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska 99775 7000, USA
    J Neurosci 31:10752-8. 2011
    Torpor in hibernating mammals defines the nadir in mammalian metabolic demand and body temperature that accommodates seasonal periods of reduced energy availability...
  35. pmc A thermosensory pathway that controls body temperature
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Nat Neurosci 11:62-71. 2008
    Defending body temperature against environmental thermal challenges is one of the most fundamental homeostatic functions that are governed by the nervous system...
  36. pmc Influence of hydration on physiological function and performance during trail running in the heat
    Douglas J Casa
    Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    J Athl Train 45:147-56. 2010
    ..Investigators in these field studies did not control exercise intensity, a known modulator of body core temperature...
  37. ncbi The mammalian circadian timing system: synchronization of peripheral clocks
    C Saini
    Department of Molecular Biology and National CCR Frontiers in Genetics, Sciences III, University of Geneva, 1211 Geneva 4, Switzerland
    Cold Spring Harb Symp Quant Biol 76:39-47. 2011
  38. ncbi Does basal metabolic rate contain a useful signal? Mammalian BMR allometry and correlations with a selection of physiological, ecological, and life-history variables
    Craig R White
    Department of Environmental Biology, School of Earth and Environmental Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia
    Physiol Biochem Zool 77:929-41. 2004
    ..of the relationship between mammalian body mass (M, g) and BMR that accounts for variation associated with body temperature, digestive state, and phylogeny...
  39. ncbi Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day
    J K Wyatt
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 277:R1152-63. 1999
    ..20-h rest/activity cycle, resulting in desynchrony between the sleep-wake cycle and the circadian rhythms of body temperature and melatonin...
  40. ncbi Effects of dietary resveratrol on the sleep-wake cycle in the non-human primate gray mouse lemur (Microcebus murinus)
    F Pifferi
    UMR CNRS MNHN 7179, Brunoy, France
    Chronobiol Int 29:261-70. 2012
    ..The present data suggest that RSV may be a potent regulator of sleep-wake rhythms and could be of major interest in the study of sleep perturbations associated with aging and neuropathology...
  41. pmc Hyperthermia impairs short-term memory and peripheral motor drive transmission
    S Racinais
    ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Exercise and Sports Science Department, Doha, Qatar
    J Physiol 586:4751-62. 2008
    ..The decrement in memory capacity suggested the existence of frontal lobe activity impairments. Thus, HHC preserved memory capacity but not the visual memory...
  42. ncbi Hemoglobin senses body temperature
    G M Artmann
    Division Juelich, Aachen University of Applied Sciences, Juelich, Germany
    Eur Biophys J 38:589-600. 2009
    ..In NMR T(1)-relaxation time measurements, the T(1) of RBCs in autologous plasma changed from a linear (r = 0.99) increment below T(c) = 37 +/- 1 degrees C at a rate of 0.023 s/K into zero slope above T(c) (RBC T(1) transition)...
  43. pmc Fever detection in under 5 children in a tertiary health facility using the infrared tympanic thermometer in the oral mode
    Benedict O Edelu
    Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria
    Ital J Pediatr 37:8. 2011
    Monitoring of body temperature is an important clinical procedure in the care of sick children, especially the under-5 children, as many disease conditions present with fever...
  44. pmc Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    A Zimmer
    Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:5780-5. 1999
    ..Thus, most, but not all, CNS effects of Delta9-THC are mediated by the CB1 receptor...
  45. ncbi Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling
    M A De Georgia
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurology 63:312-7. 2004
    ..To report results of a randomized pilot clinical feasibility trial of endovascular cooling in patients with ischemic stroke...
  46. ncbi Effects of waking time and breakfast intake prior to evaluation of physical performance in the early morning
    Clement Bougard
    Universite de Caen, EA3917, UFR STAPS, Caen, France
    Chronobiol Int 26:307-23. 2009
    Diurnal variation in both core body temperature and indicators of physical performance are usually observed when measures are taken at 06:00 and 18:00 h...
  47. ncbi Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat
    Paul M L Janssen
    Institute of Molecular Cardiobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Heart Circ Physiol 282:H499-507. 2002
    ..We conclude that temperature independently affects contraction and relaxation, and cross-bridge cycling kinetics become rate limiting for cardiac relaxation under experimental conditions closest to those in vivo...
  48. ncbi The interrelationship between sleep regulation and thermoregulation
    Kurt Krauchi
    Thermophysiological Chronobiology, Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Switzerland
    Front Biosci (Landmark Ed) 15:604-25. 2010
    The circadian distribution of vigilance states and body temperature changes are tightly coupled. The increase in heat loss at the end of the day is associated with increased ease to fall asleep...
  49. ncbi Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic Fever in cynomolgus macaques
    D A Alves
    Center for Vaccine Research, University of Pittsburgh, 8037 BST3, 3051 Fifth Avenue, Pittsburgh, PA 15261, USA
    Vet Pathol 47:831-51. 2010
    ..These macaques exhibited a number of features similar to those of human filovirus infections; as such, this model of aerosolized MARV-Angola might be useful in developing medical countermeasures under the Animal Rule...
  50. ncbi Blood cell dynamics during hibernation in the European Ground Squirrel
    H R Bouma
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, The Netherlands
    Vet Immunol Immunopathol 136:319-23. 2010
    ..5h after onset of arousal, even before body temperature is fully normalized.
  51. ncbi Physiology of invasion: cane toads are constrained by thermal effects on physiological mechanisms that support locomotor performance
    Frank Seebacher
    Integrative Physiology, School of Biological Sciences A08, University of Sydney, NSW 2006, Australia
    J Exp Biol 214:1437-44. 2011
    ..It is likely that human-induced global warming will facilitate invasions of environments that are currently too cool to support cane toads...
  52. ncbi Body temperature and response to thrombolytic therapy in acute ischaemic stroke
    M Millan
    Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Eur J Neurol 15:1384-9. 2008
    To determine the relationship between body temperature (BT), arterial recanalization, functional outcome, and hemorrhagic transformation (HT) of cerebral infarction in patients treated with i.v. tissue plasminogen activator (tPA).
  53. ncbi Real-time monitoring of cardiovascular function in rhesus macaques infected with Zaire ebolavirus
    Mark G Kortepeter
    Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University, Bethesda, MD 20814, USA
    J Infect Dis 204:S1000-10. 2011
    ..This is the first report of continuous physiologic monitoring in filovirus-infected nonhuman primates and the first to attempt cardiovascular support with intravenous fluids...
  54. pmc Alterations in cognitive performance during passive hyperthermia are task dependent
    Nadia Gaoua
    Research and Education Centre, ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar
    Int J Hyperthermia 27:1-9. 2011
  55. ncbi Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury
    Hari Shanker Sharma
    Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:242-58. 2008
  56. pmc The ingestible telemetric body core temperature sensor: a review of validity and exercise applications
    Christopher Byrne
    School of Sport and Health Sciences, St Luke s Campus, University of Exeter, Exeter EX1 2LU, UK
    Br J Sports Med 41:126-33. 2007
    ..It is concluded that the ingestible telemetric temperature sensor represents a valid index of Tc and shows excellent utility for ambulatory field-based applications...
  57. pmc Cardiovascular function in the heat-stressed human
    C G Crandall
    Department of Internal Medicine Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, and University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231, USA
    Acta Physiol (Oxf) 199:407-23. 2010
    ..These alterations in cardiovascular function and regulation late in heat stress/dehydration exercise might involve the interplay of both local and central reflexes, the contribution of which is presently unresolved...
  58. ncbi Natural resistance to liver cold ischemia-reperfusion injury associated with the hibernation phenotype
    Susanne L Lindell
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Dr, Madison WI 53706, USA
    Am J Physiol Gastrointest Liver Physiol 288:G473-80. 2005
    ..Because hibernation-induced protection is not dependent on animals being in the torpid state, the mechanisms responsible for this effect may provide new strategies for liver preservation in humans...
  59. pmc Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration
    Robert Field
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Brain Behav Immun 24:996-1007. 2010
    ..That systemic poly I:C accelerates neurodegeneration has implications for the control of systemic viral infection during chronic neurodegeneration and indicates that type I interferon responses in the brain merit further study...
  60. pmc Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology
    Andrew J K Phillips
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Rhythms 26:441-53. 2011
    ..Our findings suggest that feedback from behavioral choices to physiology could play an important role in spontaneous internal desynchrony...
  61. ncbi Passive hyperthermia reduces voluntary activation and isometric force production
    Shawnda Morrison
    Human Performance Laboratory, Faculty of Kinesiology, University of New Brunswick, Fredericton, NB, E3B 5A3, Canada
    Eur J Appl Physiol 91:729-36. 2004
    ..05). We conclude that an elevated T(c) reduces VA during isometric MVC, and neither T(sk) nor cardiovascular or psychophysical strain modulates this response. Results are given as mean (SD) unless otherwise stated...
  62. ncbi The suprachiasmatic nucleus participates in food entrainment: a lesion study
    M Angeles-Castellanos
    Departamento de Anatomia, Fac de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF
    Neuroscience 165:1115-26. 2010
    ..The present results indicate that the SCN participates actively during food entrainment modulating the response of hypothalamic and corticolimbic structures, resulting in an increased anticipatory response...
  63. ncbi Body temperature variability (Part 1): a review of the history of body temperature and its variability due to site selection, biological rhythms, fitness, and aging
    Greg Kelly
    Altern Med Rev 11:278-93. 2006
    b>Body temperature is a complex, non-linear data point, subject to many sources of internal and external variation...
  64. ncbi Chronic circadian disturbance by a shortened light-dark cycle increases mortality
    Noheon Park
    Department of Biological Sciences, Seoul National University, Seoul, Korea
    Neurobiol Aging 33:1122.e11-22. 2012
    ..We found that the disturbed rhythms of locomotor activity and body temperature resulted from interaction of endogenous clock and T cycle and the chronic state of the disturbance suppressed ..
  65. ncbi Timing for fever-related brain damage in acute ischemic stroke
    J Castillo
    Department of Neurology, Complexo Hospitalario Universitario de Santiago Hospital Xeral de Galicia, Barcelona, Spain
    Stroke 29:2455-60. 1998
    ..The aim of this study was to determine the prognostic value of body temperature measured at different times after onset of stroke.
  66. pmc The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1
    J L Teeling
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East SO167PX, UK
    Brain Behav Immun 24:409-19. 2010
    ..Changes in body temperature, open-field activity, and burrowing were assessed and mRNA and/or protein levels of inflammatory mediators ..
  67. ncbi Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke
    Bartosz Karaszewski
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XU, UK
    Brain 132:955-64. 2009
    ..Early brain temperature elevation may result from different mechanisms to those which raise body temperature after stroke...
  68. pmc The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice
    Eva Szentirmai
    Sleep and Performance Research Center, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 106:14069-74. 2009
    ..knockout mice enter hypothermic bouts associated with reduced sleep, culminating in a marked drop in body temperature to near-ambient levels...
  69. ncbi Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics
    Magi Farre
    Pharmacology Research Unit, Institut Municipal d Investigació Mèdica Hospital del Mar, Doctor Aiguader 88, E 08003 Barcelona, Spain
    J Pharmacol Exp Ther 323:954-62. 2007
    ..Marked decrease in the effects of MDMA could lead users to take higher doses of MDMA and to produce potential life-threatening toxic effects...
  70. ncbi Thermoregulation as a sleep signalling system
    Saul S Gilbert
    Centre for Sleep Research, Level 5, The Basil Hetzel Institute, University of South Australia, The Queen Elizabeth Hospital, Woodville Road, Woodville, SA 5011, Australia
    Sleep Med Rev 8:81-93. 2004
    Temperature and sleep are interrelated processes. Under normal environmental conditions, the rhythms of core body temperature Tc and sleep propensity vary inversely across the day and night in healthy young adults...
  71. ncbi Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature
    Alla Y Rudaya
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, 350 W Thomas Rd, Phoenix, Arizona 85013, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1244-52. 2005
    ..The present investigation identifies experimental conditions to study LPS-induced mono-, bi-, and polyphasic fevers and late hypothermia in mice and provides detailed characteristics of these responses...
  72. ncbi Dynamics of frontal EEG activity, sleepiness and body temperature under high and low sleep pressure
    C Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland
    Neuroreport 12:2277-81. 2001
    ..pressure) vs sleep satiation (low sleep pressure) on waking EEG dynamics, subjective sleepiness and core body temperature (CBT) was investigated in 10 young volunteers in a 40 h controlled constant posture protocol...
  73. pmc Temperature monitoring and perioperative thermoregulation
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic P77, Cleveland, Ohio 44195, USA
    Anesthesiology 109:318-38. 2008
    ..Nonetheless, temperature can be reliably measured in most patients. Body temperature should be measured in patients undergoing general anesthesia exceeding 30 min in duration and in patients ..
  74. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  75. ncbi The circadian rhythm of core temperature: origin and some implications for exercise performance
    Jim Waterhouse
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Chronobiol Int 22:207-25. 2005
    ..This interaction is manifest in the initial response to spontaneous activity and to mild exercise, body temperature rising more quickly and thermoregulatory reflexes being recruited less quickly around the trough and rising ..
  76. ncbi Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol 93:58-64. 2002
  77. ncbi Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study
    L P Kammersgaard
    Department of Neurology, University Hospital Gentofte, Copenhagen, Denmark
    Stroke 33:1759-62. 2002
    b>Body temperature is considered crucial in the management of acute stroke patients. Recently hypothermia applied as a therapy for stroke has been demonstrated to be feasible and safe in acute stroke patients...
  78. ncbi Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains
    J Adriaan Bouwknecht
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Behav Brain Res 136:489-501. 2002
    ..We conclude that a combination of behavioral and physiological responses might lead to a better understanding in anxiety-related processes...
  79. ncbi Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance
    Vladimir Kus
    Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague, Czech Republic
    Am J Physiol Endocrinol Metab 295:E356-67. 2008
  80. ncbi Hibernation and daily torpor minimize mammalian extinctions
    Fritz Geiser
    Centre for Behavioural and Physiological Ecology, Zoology, University of New England, Armidale, NSW 2351, Australia
    Naturwissenschaften 96:1235-40. 2009
    ..5%) of 61 recently extinct mammal species were homeothermic, maintaining a constant high body temperature and thus energy expenditure, which demands a high intake of food, long foraging times, and thus exposure to ..
  81. ncbi Food-anticipatory circadian rhythms: concepts and methods
    Ralph E Mistlberger
    Department of Psychology, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada
    Eur J Neurosci 30:1718-29. 2009
  82. pmc Elevated expression of protein biosynthesis genes in liver and muscle of hibernating black bears (Ursus americanus)
    Vadim B Fedorov
    Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska 99775, USA
    Physiol Genomics 37:108-18. 2009
  83. ncbi Invited review: aging and human temperature regulation
    W Larry Kenney
    Noll Physiological Laboratory Research Center, Pennsylvania State University, University Park, PA 16802 6900, USA
    J Appl Physiol (1985) 95:2598-603. 2003
  84. ncbi Sex differences in emotional and psychophysiological responses to musical stimuli
    Urs M Nater
    Institute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Switzerland
    Int J Psychophysiol 62:300-8. 2006
    ..Furthermore, our study indicates that the confounding effects of sex differences have to be considered when using musical stimuli for emotion induction...
  85. ncbi A pilot study of rapid cooling by cold saline and endovascular cooling before reperfusion in patients with ST-elevation myocardial infarction
    Matthias Götberg
    Department of Coronary Heart Disease, Skane University Hospital, Lund University, Lund, Sweden
    Circ Cardiovasc Interv 3:400-7. 2010
    ..We aimed to evaluate the safety and feasibility of rapidly induced hypothermia by infusion of cold saline and endovascular cooling catheter before reperfusion in patients with acute myocardial infarction...
  86. ncbi Circadian pattern of sleep, energy expenditure, and body temperature of young healthy men during the intermittent fasting of Ramadan
    Ahmed BaHammam
    The University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Appetite 54:426-9. 2010
    ..delay in the acrophase of skin temperature during Ramadan, indicating a shift in the circadian pattern of body temperature. Additionally, there was a delay in the peak of energy expenditure during R1 and R2...
  87. ncbi Natural hypometabolism during hibernation and daily torpor in mammals
    Gerhard Heldmaier
    Department of Biology, Philipps University, Karl von Frisch Strasse, D 35032 Marburg, Germany
    Respir Physiol Neurobiol 141:317-29. 2004
    ..b>Body temperature gradually decreases towards the level of ambient temperature...
  88. ncbi Influence of admission body temperature on stroke mortality
    Y Wang
    Centre for Clinical Epidemiology and Biostatistics, Royal Newcastle Hospital, New South Wales, Australia
    Stroke 31:404-9. 2000
    The influence of body temperature on stroke outcome remains uncertain...
  89. pmc Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
    Xiaotuan Liu
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Invest 111:399-407. 2003 oxygen consumption and physical activity of mutant and wild-type mice are indistinguishable; however, body temperature is higher in UCP1-deficient mice by 0.1-0.3 degrees C, and respiratory quotient is slightly reduced...
  90. ncbi The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse
    J Adriaan Bouwknecht
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neurosci Biobehav Rev 31:41-59. 2007
    ..The advantages and disadvantages of the SIH procedure as a physiological model of anxiety are discussed...
  91. ncbi Therapeutic hypothermia for acute stroke
    Tom Skyhøj Olsen
    Stroke Unit, Hvidovre University Hospital, DK 2650, Hvidovre, Denmark
    Lancet Neurol 2:410-6. 2003
    ..b>Body temperature is directly related to stroke severity and outcome, and fever after stroke is associated with substantial ..
  92. ncbi [Aging and biological rhythms in primates]
    Martine Perret
    UMR 5176 CNRS MNHN, Département Ecologie et Gestion de la Biodiversité, 4, avenue du Petit Château, 91800 Brunoy, France
    Med Sci (Paris) 22:279-83. 2006
    ..Aging induces a decrease in amplitude of the body temperature rhythm and an increase in energy consumption...
  93. ncbi Effect of time of day on aerobic contribution to the 30-s Wingate test performance
    Nizar Souissi
    Research Unit, Evaluation, Sport, Health, National Centre of Medicine and Science in Sport, Route de l Aéroport, Sfax 3000, Tunisia
    Chronobiol Int 24:739-48. 2007
    ..A significant circadian rhythm was found in body temperature with a circadian acrophase at 18:16+/-00:25 h as determined by cosinor analysis...
  94. ncbi The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 8:434-40. 2009
    High body temperature in the first 12-24 h after stroke onset is associated with poor functional outcome...
  95. ncbi Increased benefit of alteplase in patients with ischemic stroke and a high body temperature
    Inger de Ridder
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Cerebrovasc Dis 35:60-3. 2013
    In observational studies, a high body temperature has been associated with unfavorable outcome. In in vitro studies, the fibrinolytic activity of alteplase decreased 5% per degree Celsius reduction in temperature...
  96. pmc Sex- and age-specific differences in core body temperature of C57Bl/6 mice
    Manuel Sanchez-Alavez
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Age (Dordr) 33:89-99. 2011
    ..Thus, gonadal-dependent modulation of Tc may be one of the physiological parameters contributing to gender-specific differences in longevity...
  97. pmc Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study
    Byung Ho Lee
    Department of Anesthesiology, St Paul s Hospital, Catholic University of Korea, Seoul, Republic of Korea
    Crit Care 16:R33. 2012
    ..The association of fever and antipyretics with mortality, however, may be different between infective and non-infective illness...
  98. pmc Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    Elayne Hondares
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
    Cell Metab 11:206-12. 2010
    ..found that this enhanced the expression of genes involved in thermogenesis within brown fat, and increased body temperature. Brown adipocytes treated with FGF21 exhibited increased expression of thermogenic genes, higher total and ..
  99. ncbi Stroke severity determines body temperature in acute stroke
    G Boysen
    Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Stroke 32:413-7. 2001
    ..Experimental studies showing that hyperthermia increases infarct size have lent credibility to this assumption. The aim of the present study was to test the hypothesis that initial body temperature is of importance for stroke outcome.
  100. ncbi Effectiveness of resistive heating compared with passive warming in treating hypothermia associated with minor trauma: a randomized trial
    A Kober
    Ludwig Boltzmann Institute, University of Vienna, Austria
    Mayo Clin Proc 76:369-75. 2001
    ..Hypothermia is common even in persons with minor trauma. Resistive heating during transport augments thermal comfort, increases core temperature, reduces pain and anxiety, and improves overall patient satisfaction...
  101. ncbi Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats
    Ratchanee Rodsiri
    School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Psychopharmacology (Berl) 213:365-76. 2011
    ..3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia...

Research Grants74

  1. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..For Aim 1, we will monitor the body temperature, body weight, activity, feeding behavior and food and water intake of wild-type, procolipase- deficient and ..
  2. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Therapeutic hypothermia (TH) protocols consist of mild lowering of core body temperature (32-34[unreadable]C) and have proven effective in increasing survival and functional outcome following multiple ..
  3. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..characterized a spontaneous mutant mouse on a B6 background, Misty, that has non-functioning BAT, low body temperature, enhanced SNS tone, low trabecular bone mass with a small periosteal envelope...
  4. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..starting at one week, two weeks or two months of age on oxygen consumption (VO2), respiratory quotient (RQ), body temperature and expression of genes related to insulin action, fat and carbohydrate metabolism. 2...
  5. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..TRPV1 is activated by heat and protons, but it is unlikely that either high body temperature or acid directly activate TRPV1 in vivo...
  6. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..Temperature management is one method to reduce secondary injury. However, the optimal goal for body temperature following TBI has not been identified...
  7. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..We will examine this reflex and its enhancement by increased body temperature in neonatal piglets in an effort to find tests for SIDS susceptibility and preventive treatments for infants ..
  8. Hypothermia, anesthesia and NMR metabolomics in ischemic neonatal brain slices
    Lawrence Litt; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Therapeutic hypothermia (lowering of body temperature), administered according to protocols (duration, temperature) has recently been found to improve neurological ..
  9. Sex Differences in the Cannabioid Regulation of Energy Homeostasis
    Edward J Wagner; Fiscal Year: 2013
    ..goal of this proposal is to gain a better understanding of the cannabinoid regulation of appetite, core body temperature, metabolism, and the cellular mechanism(s) by which they affect the excitability of proopiomelanocortin (POMC)..
  10. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..These mice are characterized by diminished body fat, increased food intake and body temperature and a decreased ability to exercise...
  11. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..We showed that IgM-ALA bind to leucocyte receptors in a highly specific manner and at body temperature does not cause leucocyte cell death despite presence of complement...
  12. Recombinant life attenuated vaccine against Argentine hemorrhagic fever
    Slobodan Paessler; Fiscal Year: 2013
    ..For this, we will determine clinical parameters associated with immunization of rCandid1cSD including: body temperature and weight, overall activity, assessment of hematological and clinical pathology data covering kidney and ..
  13. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ..We propose to use indirect calorimetry and a telemetry-based heart rate and body temperature detection system to measure these physiological variables in mice at different ambient temperatures while ..
  14. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..Forced hypothermia is currently used clinically to lower body temperature and works by overwhelming the body's thermoregulatory mechanisms that resist cooling...
  15. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2012
    ..of PO/AH neurons involved in thermoregulation and we predict that this action determines the changes in body temperature and energy expenditure induced by histamine...
  16. Genetic Control of Heart Function in a Hibernating Mammal
    Matthew T Andrews; Fiscal Year: 2010
    ..The fundamental adaptation present in natural hibernators is greatly reduced body temperature, metabolism and respiration- conditions that buy precious time in cases of myocardial ischemia, traumatic ..
  17. Short-term responses to temperature changes in Escherichia coli
    Christine A White Ziegler; Fiscal Year: 2010
    ..well studied is the response of bacteria to temperatures they might normally encounter in the human host (body temperature-37[unreadable]C) and in external settings inhabited by humans (room temperature- 20[unreadable]C-23[..
  18. Recombinant Polymers for Transarterial Chemoembolization of Liver Cancer
    AZADEH POURSAID; Fiscal Year: 2013 a low viscosity fluid at room temperature followed by optimal embolization by a highly stable hydrogel at body temperature. The first aim of the proposed research consists of engineering a SELP formulation with suitable viscosity ..
  19. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    Project Summary Fever is a defended elevation in body temperature that plays a significant role in the acute phase reaction stimulated by a cascade of endogenous pyrogens released during infection...
  20. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Ivan Csanaky; Fiscal Year: 2013
    ..Our preliminary studies indicate that Oatp1b2-null mice have unexpected difficulty in maintaining their body temperature during surgical experiments, but are protected from lipopolysaccharide-induced hypothermia and hyperalgesia...
  21. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2013 side effects include modulation of respiration, locomotor activity, rotorod performance, and body temperature. Experiments with morphine and P450 inhibitors in rats and with morphine in BCPRN mice will discover which of ..
  22. Developing Radiological Risk Communication Materials for Low-Literacy Populations
    SARAH B BASS; Fiscal Year: 2010
    ..physiological measures (eye-tracking, pupil dilation, heart rate, respiration rate, skin conductance and body temperature) to assess their effectiveness in reducing fear and increasing willingness to comply with recommended actions...
  23. Role of thermoregulatory leptin action via the DMH in body weight control
    KAVON PAUL REZAI-ZADEH; Fiscal Year: 2013
    ..LepRb expressing neurons in vivo to study their effect on body weight/composition, energy expenditure, and body temperature during nutritional challenges in two aims...
  24. Unihemispheric sleep: implications for mechanisms of sleep control and function i
    Jerome M Siegel; Fiscal Year: 2013
    ..state from those linked to behavioral quiescence with its associated heart rate, muscle tone, respiration and body temperature reductions...
  25. Alteration of circadian rhythm and sleep by HIV protein Tat
    Jian M Ding; Fiscal Year: 2012
    ..Circadian rhythms are physiological functions that manifest a 24-hr period, including sleep-wake cycle, body temperature, neuroendocrine and neuroimmune interactions...
  26. Infant Sleep Environment Monitoring System (SEMS) for SIDS
    ROBERT A LIEBERMAN; Fiscal Year: 2012
    ..Carbon dioxide and Temperature - In clinically significant head-covering episodes, CO2 accumulates and body temperature rises, leading to CO2 rebreathing, heat stress and ultimately respiratory suppression and apnea...
  27. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2013
    ..medical complication including heart attacks, heart failure, muscle breakdown and severe elevations in body temperature. By identifying the brain areas and chemical receptors responsible for causing MDMA's toxicity, our ..
  28. Circadian dysfunction and GSK3 in neurodegenerative disease
    Karen L Gamble; Fiscal Year: 2013
    ..late afternoon/evening hyperactivity, restlessness, confusion, and aggression, along with misaligned core body temperature and activity rhythms...
  29. Improving the Kinetics and Reliability of Continuous Glucose Monitoring
    Brett D Mensh; Fiscal Year: 2012
    ..These tests will be done under baseline conditions, then again during changes in body temperature and blood pressure, to test robustness. We will measure lag times and lag-time variability in all cases...
  30. Circadian light entrainment following genetic ablation of retinal glutamate trans
    HEINRICH SELWYN GOMPF; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Timing of physiological processes such as hormone release, body temperature, blood pressure in anticipation of daily environmental cycles is governed by an internal master clock, which ..
  31. Protease Operated Depot for Delivery of GLP-1
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..polypeptide (ELP) that is soluble at room temperature but forms a viscous coacervate depot upon injection at body temperature, and repeats of GLP-1 that have recognition sites for a specific protease, embedded between repeats of the ..
  32. AccuTemp Sensor: Radiometry based non-invasive continuous core body temperature m
    DOUGLAS O REUDINK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Accurate measurement of core body temperature during surgery as well as in critical care is imperative to a positive outcome and ongoing quality of life for patients...
  33. Reversal of Spermatogonial Arrest in Mice
    Gunapala Shetty; Fiscal Year: 2012
    ..spermatogonia and spermatocytes of jsd mice at scrotal temperatures, and if processing is more efficient at body temperature. (III) Determine the specific or general metabolic processes that are altered by elevation of temperature to ..
  34. The Role of Melatonin in Natural Neuroprotection
    Christine Schwartz; Fiscal Year: 2013
    ..Hibernating ground squirrels undergo rapid and extreme changes in body temperature and brain perfusion as they cycle between lengthy torpor bouts (7-10 days) and brief periods of euthermia ..
  35. The Role of Hypocretins in the Regulation of Stress and Arousal
    MATTHEW E CARTER; Fiscal Year: 2010
    ..activity, as well as changes in physiological state, such as an increase in heart rate, blood pressure, and body temperature. If the stress response is excessive and prolonged, as frequently occurs in the busy lives of Americans, the ..
  36. Regulation of pacemaking and bursting of substantia nigra dopamine neurons by cal
    CYNTHIA N KIMM; Fiscal Year: 2013
    ..but these studies used barium as a charge carrier instead of calcium and were performed at room rather than body temperature (Cardozo and Bean, 1995;Durante et al., 2004)...
  37. Glial Modulation of Autonomic Nervous System Activity
    KEN DOUGLAS MCCARTHY; Fiscal Year: 2013 a marked increase in blood pressure, heart rate, saliva formation, and piloerection, and a decrease in body temperature;each of these parameters are regulated by the autonomic nervous system...
  38. Circuitry for circadian rhythms
    Clifford B Saper; Fiscal Year: 2013
    ..proposal we will study the brain circuitry that underlies circadian timing of wake-sleep, feeding, activity, body temperature, and secretion of melatonin and corticosteroids...
  39. Molecular Probes for Biomembrane Recognition
    Bradley D Smith; Fiscal Year: 2013
    ..that the nanoparticles can be stored at low temperature and they only become chemiluminescent when warmed to body temperature. Preliminary results in mice show that chemiluminescence imaging permits identification of target sites that ..
  40. Leptin and Central Control of Thermoregulation
    ..Thermogenesis is necessary to maintain body temperature, but also affects energy expenditure and body weight...
    Shin Ichiro Imai; Fiscal Year: 2013
    ..central adaptive responses to DR, including the augmentation of physical activity and the maintenance of body temperature, through the up-regulation of the Ox2r expression and the neural activation in the DHM and LH...
  42. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..activated phosphatase calcineurin was demonstrated to govern a signaling cascade enabling growth at mammalian body temperature and virulence...
  43. Neural Mechanisms of Diurnality: Role of the Intergeniculate Leaflet
    ANDREW JASON GALL; Fiscal Year: 2013
    ..Specifically, many of these patients exhibit increased levels of nocturnal activity, aberrant sleep and body temperature rhythms, and disrupted masking responses to light...
  44. Mechanisms of temperature buffering in C. elegans
    LISA NICOLE PETRELLA; Fiscal Year: 2011
    ..In organisms that cannot control their internal body temperature, there are differing rates of development as temperatures change and this requires mechanisms to buffer ..
  45. Circadian Biology at the Supra-Organismal Level
    William J Schwartz; Fiscal Year: 2013
    ..We have also developed and tested miniature implantable devices for longitudinally recording body temperature and general locomotor activity in individual rodents...
  46. Social and psychological risk for infectious illness
    Sheldon A Cohen; Fiscal Year: 2010
    ..nasal pro-inflammatory, anti-inflammatory and anti-viral cytokine production, nasal and general symptoms, body temperature, nasal secretion production and nasal mucociliary clearance function...
  47. Determining the Mechanism of Temperature Compensation of the Circadian Clock
    Deborah Bell-Pedersen; Fiscal Year: 2013
    ..This process, called temperature compensation (TC), is conserved in organisms that maintain their own body temperature. However, the mechanism of TC, and the impact of TC in circadian health is not known...
  48. NIH Director's Pioneer Award
    Cheng C Lee; Fiscal Year: 2010
    ..undergo a physiological state analogous to reversible suspended animation, with severe hypothermia and a core body temperature (CBT) close to 0oC. In non-hibernators including the human, this degree of hypothermia is fatal...
  49. Electrophysiology of zona incerta neurons
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2013
    ..Maintenance of body temperature is central to energy homeostasis in mammals because it represents a major part of the energy expenditure of ..
  50. Alcohol Consumption and Brown Adipose Tissue
    William S Blaner; Fiscal Year: 2013
    ..Our preliminary data reveal that chronic alcohol consumption is associated with a dysregulation of body temperature maintenance, as well as a very marked decrease in BAT mass...
  51. Rapid Transition Polymer for Temporary Vascular Occlusion During Segmental Liver
    PETER NATHAN MADRAS; Fiscal Year: 2010
    ..Polymers" (RTP's") that exist in a liquid state at low temperatures but quickly transition to gel near body temperature. This phase change is fully reversible by cooling and the polymer cannot re-solidify once dissolved...
  52. Metabolic Adaptation After 2 Years of Caloric Restriction in Non-Obese Humans
    Eric Ravussin; Fiscal Year: 2012
    ..whether a lowering of the "rate of living" (energy metabolism) is associated with an accompanying decrease in body temperature and oxidative stress in 50 volunteers consuming 25% less calories per day for 2 years...
  53. Integration of Circadian Rhythm and Metabolism through Coactivator PGC-1alpha
    Jiandie D Lin; Fiscal Year: 2012
    ..Mice deficient in PGC-1[unreadable] have aberrant circadian rhythms of locomotor activity, body temperature, metabolic rate, and diurnal patterns of metabolic gene expression...
  54. Temperature control of the C. elegans circadian clock
    ..g. sleep, mood, body temperature), and disruption of these rhythms can either cause or affect the severity of most neurological disorders...
  55. Identifying Novel Targets for Recruitment of Brown Adipocytes
    Olivier Boss; Fiscal Year: 2013 increased upon exposure to low temperatures, and plays an important role in the maintenance of body temperature and energy balance in rodents...
  56. Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol
    Richard E Peltier; Fiscal Year: 2013
    ..mouse will be surgically implanted with radio telemetry devices for real time measurement of mouse activity, body temperature, and 2-channel electrocardiogram...
  57. Targeting Central A1 Adenosine Receptors Induces Hypothermia for Stroke
    Kelly L Drew; Fiscal Year: 2013
    ..via activation of brain A1 adenosine receptors (A1AR), a mechanism used by hibernating mammals to decrease body temperature during onset of hibernation...
  58. Individually tailored lighting system to improve sleep in older adults
    MARIANA FIGUEIRO; Fiscal Year: 2013
    ..showed that monochromatic 530-nm (green) light delivered through the eyelids before predicted minimum core body temperature (CBTmin) acutely suppressed melatonin and delayed dim light melatonin onset (DLMO)...
  59. Stroke Treatment by Chemically-Induced Hypothermia
    Shan Ping Yu; Fiscal Year: 2012
    ..There are consistent animal and human data that mild to moderate hypothermia (reducing body temperature to 32-34oC) is generally safe and improves outcome after brain ischemia even when initiated hours after ..
  60. Mechanisms of Ttemperature Buffering in C. Elegans
    LISA NICOLE PETRELLA; Fiscal Year: 2013
    ..In organisms that cannot control their internal body temperature, there are differing rates of development as temperatures change and this requires mechanisms to buffer ..
  61. The Responses of Thermoregulatory Neurons to CGRP
    John Griffin; Fiscal Year: 2009
    ..This transient hyperthermic shift in body temperature has been linked to the neuropeptide calcitonin gene-related peptide (CGRP), which acts peripherally to ..
  62. Inflammatory markers as predictors of active labor onset among nulliparous women
    Jeremy L Neal; Fiscal Year: 2011
    ..cell (WBC) count, serum pro-inflammatory cytokines (IL-12, IL-6, IL-8, TNF-1), C-reactive protein (CRP);and body temperature] over time and the amount of cervical dilation during the first 4 hrs post-admission...
    RICHARD LEE JR; Fiscal Year: 1991
    ..Freezing is accompanied by the release of the heat of crystallization which elevates body temperature and causes an increase in the heart rate for at least 10 hours...
    Robert Zoeller; Fiscal Year: 1993
    ..Thyroid hormones are important regulators of body temperature. Accidental hypothermia is often finked to ethanol intoxication, and alcohol abuse or dependence is often ..
  65. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..wearable, low-power, form-friendly, wireless, wrist-based device that provides the following functions: (1) Body Temperature (2) Pulse Oximetry (3) Heart Rate and (4) Location Information...
  66. An injectable biocompatible hydrogel nucleus pulposus replacement
    Gavin Braithwaite; Fiscal Year: 2009
    ..i) to exist as a liquid pre-gel that can be injected safely through an narrow gauge needle;(ii) to gel at body temperature and environment within minutes;(iii) to be space-filling and resist extrusion from annular tears, (iv) to ..
  67. Anxiolytic Property of Atypical Antipsychotics
    Ming Li; Fiscal Year: 2009
    ..g., body temperature, defecation, urination, ultrasonic vocalization), which enable evaluation of the anxiolytic properties of ..
  68. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..The degree of these effects is influenced by animal species, strain, body temperature, and disease state. Tumor vasculature lacks smooth muscle and cannot autoregulate blood flow...
    JACK BOULANT; Fiscal Year: 2006
    ..recordings and immunohistochemistry to study hypothalamic neuronal networks that regulate body temperature and fever...
  70. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
    ..The effects of melatonin on sleep parameters, and circadian phase of motor activity and core body temperature will be assessed by actigraphy and radiotelemetry...
  71. Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney
    PETER MADRAS; Fiscal Year: 2007
    ..At low temperatures, the polymeric solution is a liquid. As the temperature increases to body temperature, the viscosity of the solution rapidly increases several orders of magnitude to the consistency of a hard gel...
  72. LabMaster: Calo/Dri-Fed/Act.XYZ/Wheel 16 Mice/Rats
    Michael Schwartz; Fiscal Year: 2009
    ..Combined with simultaneous measures of locomotor activity, wheel running activity, and body temperature (by telemetry), this system provides not only measures of total energy expenditure, but clarifies whether ..
    John Beard; Fiscal Year: 1991
    Iron deficient and anemic humans and rats fail to maintain body temperature when cold stressed. It is not clear from existing data how much of this thermoregulatory defect is secondary to the anemic associated with iron deficiency...
    FRED CALDWELL; Fiscal Year: 1991
    ..2. That in nonseptic burn patients the increment in body temperature (TB) which is directly proportional to the size of the burn wound, reflects a shift upward in setpoint ..