saccades

Summary

Summary: An abrupt voluntary shift in ocular fixation from one point to another, as occurs in reading.

Top Publications

  1. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
  2. ncbi Eye movements in reading and information processing: 20 years of research
    K Rayner
    Department of Psychology, University of Massachusetts, Amherst 01003, USA
    Psychol Bull 124:372-422. 1998
  3. ncbi A common network of functional areas for attention and eye movements
    M Corbetta
    Department of Neurology, McDonnell Center for Higher Brain Functions, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 21:761-73. 1998
  4. ncbi Ultra-rapid object detection with saccadic eye movements: visual processing speed revisited
    Holle Kirchner
    Centre de Recherche Cerveau et Cognition UMR 5549, CNRS Université Paul Sabatier Toulouse 3, Faculte de Medecine de Rangueil, 31062 Toulouse Cedex 9, France
    Vision Res 46:1762-76. 2006
  5. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
  6. ncbi Matching behavior and the representation of value in the parietal cortex
    Leo P Sugrue
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 304:1782-7. 2004
  7. ncbi Transient induced gamma-band response in EEG as a manifestation of miniature saccades
    Shlomit Yuval-Greenberg
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Neuron 58:429-41. 2008
  8. ncbi The roles of vision and eye movements in the control of activities of daily living
    M Land
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, UK
    Perception 28:1311-28. 1999
  9. ncbi Role of the basal ganglia in the control of purposive saccadic eye movements
    O Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Physiol Rev 80:953-78. 2000
  10. ncbi Microsaccades uncover the orientation of covert attention
    Ralf Engbert
    Department of Psychology, University of Potsdam, P O Box 601553, 14415, Potsdam, Germany
    Vision Res 43:1035-45. 2003

Research Grants

Detail Information

Publications398 found, 100 shown here

  1. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
    ..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies...
  2. ncbi Eye movements in reading and information processing: 20 years of research
    K Rayner
    Department of Psychology, University of Massachusetts, Amherst 01003, USA
    Psychol Bull 124:372-422. 1998
    ..are (a) the characteristics of eye movements, (b) the perceptual span, (c) integration of information across saccades, (d) eye movement control, and (e) individual differences (including dyslexia)...
  3. ncbi A common network of functional areas for attention and eye movements
    M Corbetta
    Department of Neurology, McDonnell Center for Higher Brain Functions, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 21:761-73. 1998
    ..This anatomical overlap is consistent with the hypothesis that attentional and oculomotor processes are tightly integrated at the neural level...
  4. ncbi Ultra-rapid object detection with saccadic eye movements: visual processing speed revisited
    Holle Kirchner
    Centre de Recherche Cerveau et Cognition UMR 5549, CNRS Université Paul Sabatier Toulouse 3, Faculte de Medecine de Rangueil, 31062 Toulouse Cedex 9, France
    Vision Res 46:1762-76. 2006
    ..when two scenes are simultaneously flashed in the left and right hemifields, human participants can reliably make saccades to the side containing an animal in as little as 120 ms...
  5. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
    ..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement...
  6. ncbi Matching behavior and the representation of value in the parietal cortex
    Leo P Sugrue
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 304:1782-7. 2004
    ..We found that a simple model based on reward history can duplicate this behavior and that neurons in the parietal cortex represent the relative value of competing actions predicted by this model...
  7. ncbi Transient induced gamma-band response in EEG as a manifestation of miniature saccades
    Shlomit Yuval-Greenberg
    Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel
    Neuron 58:429-41. 2008
    ..The time course of the iGBR is related to an increase in the rate of saccades following a period of poststimulus saccadic inhibition...
  8. ncbi The roles of vision and eye movements in the control of activities of daily living
    M Land
    Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, UK
    Perception 28:1311-28. 1999
    ..This type of unconscious attention must be a common phenomenon in everyday life...
  9. ncbi Role of the basal ganglia in the control of purposive saccadic eye movements
    O Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Tokyo, Japan
    Physiol Rev 80:953-78. 2000
    In addition to their well-known role in skeletal movements, the basal ganglia control saccadic eye movements (saccades) by means of their connection to the superior colliculus (SC)...
  10. ncbi Microsaccades uncover the orientation of covert attention
    Ralf Engbert
    Department of Psychology, University of Potsdam, P O Box 601553, 14415, Potsdam, Germany
    Vision Res 43:1035-45. 2003
    ..Furthermore, our results suggest that microsaccades can be used to map the orientation of visual attention in psychophysical experiments...
  11. ncbi Fast saccades toward faces: face detection in just 100 ms
    Sébastien M Crouzet
    Centre de Recherche Cerveau and Cognition, UMR, CNRS, Universite Toulouse, Toulouse, France
    J Vis 10:16.1-17. 2010
    ..J. Thorpe (2006) found that when two images are simultaneously flashed in the left and right visual fields, saccades toward the side with an animal can be initiated in as little as 120-130 ms...
  12. ncbi Look away: the anti-saccade task and the voluntary control of eye movement
    Douglas P Munoz
    Centre for Neuroscience Studies, Department of Physiology, CIHR Group in Sensory Motor Systems, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Rev Neurosci 5:218-28. 2004
  13. ncbi Microsaccades: small steps on a long way
    Martin Rolfs
    Universite Paris Descartes, Laboratoire Psychologie de la Perception, 75006 Paris, France
    Vision Res 49:2415-41. 2009
    ....
  14. ncbi Lateral habenula as a source of negative reward signals in dopamine neurons
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 447:1111-5. 2007
    ..These results suggest that the inhibitory input from the lateral habenula plays an important role in determining the reward-related activity of dopamine neurons...
  15. pmc Eye movements: the past 25 years
    Eileen Kowler
    Department of Psychology, Rutgers University, Piscataway, NJ 08854, United States
    Vision Res 51:1457-83. 2011
    ..Emphasis is on three oculomotor behaviors: gaze control, smooth pursuit and saccades, and on their interactions with vision...
  16. pmc Cell-type-specific synchronization of neural activity in FEF with V4 during attention
    Georgia G Gregoriou
    Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete 71003, Greece
    Neuron 73:581-94. 2012
    ..These findings support the idea that the attentional modulation of visual processing is not mediated by movement neurons...
  17. ncbi Basal ganglia orient eyes to reward
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurophysiol 95:567-84. 2006
    ..These data support a specific form of reinforcement learning theories, but also suggest further refinement of the theory...
  18. pmc Free choice activates a decision circuit between frontal and parietal cortex
    Bijan Pesaran
    Center for Neural Science, New York University, New York, New York 10003, USA
    Nature 453:406-9. 2008
    ..Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals...
  19. ncbi Selective gating of visual signals by microstimulation of frontal cortex
    Tirin Moore
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 421:370-3. 2003
    ..brief stimulation of retinotopically corresponding sites within the FEF using currents below that needed to evoke saccades. The magnitude of the enhancement depended on the effectiveness of receptive field stimuli as well as on the ..
  20. ncbi Eye-hand coordination in object manipulation
    R S Johansson
    Department of Integrative Medical Biology, Section for Physiology, Umea University, S 90187 Umea, Sweden
    J Neurosci 21:6917-32. 2001
    ..For both the obstacle and target, subjects directed saccades and fixations to sites that were offset from the physical extension of the objects...
  21. ncbi Neural control of voluntary movement initiation
    D P Hanes
    Department of Psychology, Wilson Hall, Vanderbilt University, Nashville, TN 37240, USA
    Science 274:427-30. 1996
    ..This finding elucidates a specific link between motor behavior and activation of neurons in the cerebral cortex...
  22. pmc Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation
    S Rivaud-Pechoux
    INSERM U289, Hopital de la Salpetriere, 47 bd de l Hopital, 75651 Paris Cedex 13, France
    J Neurol Neurosurg Psychiatry 68:381-4. 2000
    ..STN stimulation improved the accuracy of memory guided saccades but not of reflexive visually guided saccades and had no effect on the antisaccade task...
  23. ncbi The antisaccade task as a research tool in psychopathology: a critical review
    Samuel B Hutton
    Department of Psychology, Sussex University, Brighton, UK
    Psychophysiology 43:302-13. 2006
    ....
  24. ncbi Microsaccades: a neurophysiological analysis
    Susana Martinez-Conde
    Barrow Neurological Institute, Phoenix, AZ, USA
    Trends Neurosci 32:463-75. 2009
    ..We also point out the current gaps in our understanding of the neurobiology of microsaccades and identify the most promising lines of enquiry...
  25. ncbi Decomposing the neural correlates of antisaccade eye movements using event-related FMRI
    Ulrich Ettinger
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, UK
    Cereb Cortex 18:1148-59. 2008
    ..Seventeen healthy volunteers completed event-related functional magnetic resonance imaging at 1.5 T during saccades to and away from a peripheral visual target (prosaccades and antisaccades, respectively)...
  26. ncbi Microsaccades counteract visual fading during fixation
    Susana Martinez-Conde
    Barrow Neurological Institute, 350 West Thomas Road, Phoenix, Arizona 85013, USA
    Neuron 49:297-305. 2006
    ..These results reveal a direct link between suppression of microsaccades and fading and suggest a causal relationship between microsaccade production and target visibility during fixation...
  27. pmc Pharmacological treatment effects on eye movement control
    James L Reilly
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Brain Cogn 68:415-35. 2008
    ..anticonvulsant/mood stabilizing medications is a decrease in saccade and smooth pursuit velocity (or increase in saccades during pursuit); (ii) these oculomotor effects largely reflect the general sedating effects of these medications ..
  28. pmc From salience to saccades: multiple-alternative gated stochastic accumulator model of visual search
    Braden A Purcell
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Despartment of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Neurosci 32:3433-46. 2012
    ..Adjustments in the level of gating inhibition can control trade-offs in speed and accuracy that optimize visual search performance...
  29. ncbi Saccade target selection and object recognition: evidence for a common attentional mechanism
    H Deubel
    Max Planck Institut für Psychologische Forschung, Munchen, Germany
    Vision Res 36:1827-37. 1996
    ..The results favor a model in which a single attentional mechanism selects objects for perceptual processing and recognition, and also provides the information necessary for motor action...
  30. pmc Control of visual cortical signals by prefrontal dopamine
    Behrad Noudoost
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Fairchild Building, 299 Campus Drive West, Stanford, California 94305, USA
    Nature 474:372-5. 2011
    ..Our results identify a role for D1 receptors in mediating the control of visual cortical signals by the prefrontal cortex and suggest how processing in sensory areas could be altered in mental disorders involving prefrontal dopamine...
  31. ncbi Microsaccadic efficacy and contribution to foveal and peripheral vision
    Michael B McCamy
    Department of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurosci 32:9194-204. 2012
    ....
  32. ncbi Inhibitory control in mind and brain: an interactive race model of countermanding saccades
    Leanne Boucher
    Department of Psychology, Vanderbilt University, Nashville, TN 37221, USA
    Psychol Rev 114:376-97. 2007
    ....
  33. ncbi Saccadic eye movements cause compression of time as well as space
    M Concetta Morrone
    Facolta di Psicologia, Universita Vita Salute San Raffaele, Via Olgettina 58, Milano 20132, Italy
    Nat Neurosci 8:950-4. 2005
    ..We were even more surprised that in a critical interval before saccades, perceived temporal order is consistently reversed...
  34. ncbi Spatiotopic transfer of visual-form adaptation across saccadic eye movements
    David Melcher
    Faculty of Psychology, San Raffaele University, Via Olgettina 58, 20132 Milan, Italy
    Curr Biol 15:1745-8. 2005
    ..for visual stability is that internal maps of objects and their visual properties are remapped around the time of saccades, but numerous studies have demonstrated that visual patterns are not combined across saccades...
  35. ncbi Microsaccades: A microcosm for research on oculomotor control, attention, and visual perception
    Ralf Engbert
    Computational Neuroscience, Department of Psychology, University of Potsdam, PO Box 601553, 14415 Potsdam, Germany
    Prog Brain Res 154:177-92. 2006
    ..contribution to these fixational eye movements is generated by microsaccades, which are rapid small-amplitude saccades with a rate of about one per second...
  36. pmc Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:15700-5. 2005
    ..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses...
  37. ncbi Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study
    Marc C Patterson
    Department of Neurology and Pediatrics, Columbia University, NY, USA
    Lancet Neurol 6:765-72. 2007
    ..Miglustat is able to cross the blood-brain barrier, and is thus a potential therapy for neurological diseases. We aimed to establish the effect of miglustat on several markers of NPC severity...
  38. ncbi The central fixation bias in scene viewing: selecting an optimal viewing position independently of motor biases and image feature distributions
    Benjamin W Tatler
    School of Psychology, University of Dundee, Dundee, UK
    J Vis 7:4.1-17. 2007
    ..is that experiments typically use a central pre-trial fixation marker, and observers tend to make small amplitude saccades. In the present study, the central bias was explored by dividing images post hoc according to biases in their ..
  39. pmc Top-down control of visual attention
    Behrad Noudoost
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Curr Opin Neurobiol 20:183-90. 2010
    ..We summarize this evidence and discuss its relationship to the neural mechanisms of spatial working memory...
  40. ncbi A microsaccadic rhythm modulates gamma-band synchronization and behavior
    Conrado A Bosman
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    J Neurosci 29:9471-80. 2009
    ..We hypothesize that the 3.3 Hz rhythm structures the sampling and exploration of the environment through building and breaking neuronal ensembles synchronized in the gamma-frequency band to process sensory stimuli...
  41. ncbi Two fixations suffice in face recognition
    Janet Hui wen Hsiao
    Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093 0404, USA
    Psychol Sci 19:998-1006. 2008
    ....
  42. pmc Cerebellar contributions to adaptive control of saccades in humans
    Minnan Xu-Wilson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:12930-9. 2009
    The cerebellum may monitor motor commands and through internal feedback correct for anticipated errors. Saccades provide a test of this idea because these movements are completed too quickly for sensory feedback to be useful...
  43. ncbi Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease
    A Yugeta
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurology 74:743-8. 2010
    The basal ganglia (BG) play an important role in controlling saccades. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely used as a treatment of Parkinson disease (PD) by altering the function of the BG...
  44. ncbi From eye movements to actions: how batsmen hit the ball
    M F Land
    School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    Nat Neurosci 3:1340-5. 2000
    ..Comparing players with different skill levels, we found that a short latency for the first saccade distinguished good from poor batsmen, and that a cricket player's eye movement strategy contributes to his skill in the game...
  45. pmc A neural mechanism for microsaccade generation in the primate superior colliculus
    Ziad M Hafed
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 323:940-3. 2009
    ..These results, coupled with computational modeling of SC activity, demonstrate that microsaccades are controlled by the SC and explain the link between microsaccades and visual attention...
  46. ncbi Microsaccade dynamics during covert attention
    Jochen Laubrock
    Department of Psychology, University of Potsdam, P O Box 601553, 14415 Potsdam, Germany
    Vision Res 45:721-30. 2005
    ..e., early automatic triggering of saccade programs), followed by a shift in the opposite direction (i.e, controlled inhibition of cue-directed saccades, leading to a 'leakage' of microsaccades in the opposite direction).
  47. ncbi Response times for visually guided saccades in persons with Parkinson's disease: a meta-analytic review
    Jonathan M Chambers
    Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TP, UK
    Neuropsychologia 48:887-99. 2010
    ..Investigations of visually guided, or "reflexive", saccades have, on the other hand, produced inconclusive results with studies showing response times (RTs) in persons with ..
  48. ncbi Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems
    Lucia S Simo
    Center for Cognitive Medicine, Department of Psychiatry, University of Illinois, Chicago, IL 60611, USA
    Cereb Cortex 15:1982-91. 2005
    ..guided saccade (VGS) task using unpredictable targets matched for number, direction and amplitude of required saccades. Our results show greater activation during the PRED task in the prefrontal, pre-supplementary motor and anterior ..
  49. pmc Changes in control of saccades during gain adaptation
    Vincent Ethier
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:13929-37. 2008
    ..The adapted saccades had reduced peak velocities, reduced accelerations, shallower decelerations, and increased durations compared ..
  50. pmc Neuronal mechanisms of visual stability
    Robert H Wurtz
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bldg 49, Rm 2A50, Bethesda, MD 20892 4435, USA
    Vision Res 48:2070-89. 2008
    ..For the second problem, saccadic suppression, visual masking and corollary discharge are well established mechanisms, and possible neuronal correlates have been identified for each...
  51. ncbi Toward a model of microsaccade generation: the case of microsaccadic inhibition
    Martin Rolfs
    Department of Psychology Cognitive Psychology, Universitat Potsdam, Potsdam, Germany
    J Vis 8:5.1-23. 2008
    ..in which microsaccades result from fixation-related activity in a motor map coding for both fixation and saccades. In this map, fixation is represented at the central site...
  52. pmc The mechanism underlying inhibition of saccadic return
    Casimir J H Ludwig
    University of Bristol, Department of Experimental Psychology, Bristol BS8 1TU, UK
    Cogn Psychol 59:180-202. 2009
    ..is integrated over time to a response threshold, ISR could reflect a reduction in the rate of accumulation for saccades to return locations or an increase in the effective criterion for response...
  53. ncbi A pathway in primate brain for internal monitoring of movements
    Marc A Sommer
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 296:1480-2. 2002
    ..These results identify a pathway in the brain of the primate Macaca mulatta that conveys corollary discharge signals...
  54. ncbi A visual salience map in the primate frontal eye field
    Kirk G Thompson
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Prog Brain Res 147:251-62. 2005
    ..In addition, it strengthens the emerging view that FEF is not only involved in producing overt gaze shifts, but is also important for directing covert spatial attention...
  55. ncbi The influence of visual landscape on the free flight behavior of the fruit fly Drosophila melanogaster
    Lance F Tammero
    UCB UCSF Joint Bioengineering Graduate Group, 3060 Valley Life Science Building, University of California at Berkeley, Berkeley, CA 94720, USA
    J Exp Biol 205:327-43. 2002
    ..Flies move through their environment using a series of straight flight segments separated by rapid turns, termed saccades, during which the fly alters course by approximately 90 degrees in less than 100 ms...
  56. pmc Influence of environmental statistics on inhibition of saccadic return
    Simon Farrell
    Department of Experimental Psychology, University of Bristol, Bristol BS8 1TU, United Kingdom
    Proc Natl Acad Sci U S A 107:929-34. 2010
    ....
  57. ncbi Triggering mechanisms in microsaccade and saccade generation: a novel proposal
    Jorge Otero-Millan
    Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Ann N Y Acad Sci 1233:107-16. 2011
    b>Saccades are rapid eye movements that change the line of sight between successive points of fixation...
  58. ncbi Impaired spatial working memory across saccades contributes to abnormal search in parietal neglect
    M Husain
    Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital Campus, London, UK
    Brain 124:941-52. 2001
    ..locations have already been examined during visual search: an impairment in retaining searched locations across saccades. Using a new paradigm, we monitored gaze during search, while simultaneously probing whether observers judged ..
  59. ncbi Poor saccadic control correlates with dyslexia
    M Biscaldi
    Brain Research Unit, Institute of Biophysics, University of Freiburg, Germany
    Neuropsychologia 36:1189-202. 1998
    ..group, the mean values of the standard deviations of the saccadic reaction times (SRT) and the amount of late saccades (SRT > 700) were significantly increased in both dyslexic groups and especially in group D1 who also showed an ..
  60. ncbi Saccadic dysmetria and adaptation after lesions of the cerebellar cortex
    S Barash
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 19:10931-9. 1999
    ..For saccades in one horizontal direction, the lesions led to an initial gross hypometria and a permanent abolition of the ..
  61. ncbi An examination of binocular reading fixations based on sentence corpus data
    Antje Nuthmann
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    J Vis 9:31.1-28. 2009
    ..Fixation disparity accumulates during the course of successive saccades and fixations within a line of text, but only to an extent that does not compromise single binocular vision...
  62. ncbi Binocular coordination of saccades at far and at near in children and in adults
    Qing Yang
    Laboratoire de Physiologie de la Perception et de l Action, CNRS College de France, Paris, France
    J Vis 3:554-61. 2003
    The goal of the study was to test the quality of binocular coordination of saccades in children and adults, and its dependency upon the viewing distance. Fourteen normal children (4...
  63. ncbi The control of voluntary eye movements: new perspectives
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscientist 11:124-37. 2005
    Primates use two types of voluntary eye movements to track objects of interest: pursuit and saccades. Traditionally, these two eye movements have been viewed as distinct systems that are driven automatically by low-level visual inputs...
  64. ncbi Components of bottom-up gaze allocation in natural images
    Robert J Peters
    Computation and Neural Systems, California Institute of Technology, Mail Code 139 74, Caltech, Pasadena, CA 91125, USA
    Vision Res 45:2397-416. 2005
    ..As models of these interactions become more accurate in predicting behaviorally-relevant salient locations, they become useful to a range of applications in computer vision and human-machine interface design...
  65. ncbi Visual correlates of fixation selection: effects of scale and time
    Benjamin W Tatler
    Sussex Centre for Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom
    Vision Res 45:643-59. 2005
    ..We propose that saccade target selection involves an unchanging intermediate level representation of the scene but that the high-level interpretation of this representation changes over time...
  66. ncbi Retinal image shifts, but not eye movements per se, cause alternations in awareness during binocular rivalry
    Loes C J van Dam
    Helmholtz Institute, Utrecht University, Utrecht, The Netherlands
    J Vis 6:1172-9. 2006
    ..Subjects viewed repetitive line patterns, enabling a distinction of saccades that did produce foveal image changes from those that did not. Subjects reported binocular rivalry alternations...
  67. ncbi The role of saccades in exerting voluntary control in perceptual and binocular rivalry
    Loes C J van Dam
    Helmholtz Institute, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands
    Vision Res 46:787-99. 2006
    We have investigated the role of saccades and fixation positions in two perceptual rivalry paradigms (slant rivalry and Necker cube) and in two binocular rivalry paradigms (grating and house-face rivalry), and we compared results obtained ..
  68. ncbi Deficits in saccadic eye-movement control in Parkinson's disease
    Florence Chan
    Centre for Neuroscience Studies, Queen s University, Kingston, Ont, Canada K7L 3N6
    Neuropsychologia 43:784-96. 2005
    ..soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay...
  69. ncbi White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease
    Stefan Kloppel
    Wellcome Trust Centre for Neuroimaging, Institute if Neurology, UCL, London, UK
    Brain 131:196-204. 2008
    ..the caudate body originate from the frontal eye fields, which play an important role in the control of voluntary saccades. This type of saccade is specifically impaired in PSCs and is an early clinical sign of motor abnormalities...
  70. ncbi Top-down control-signal dynamics in anterior cingulate and prefrontal cortex neurons following task switching
    Kevin Johnston
    Robarts Research Institute, London, Ontario N6A 5K8, Canada
    Neuron 53:453-62. 2007
    ..These results demonstrate that the ACC is recruited when cognitive demands increase and suggest a role for both areas in task maintenance and the implementation of top-down control...
  71. pmc Distinctive features of saccadic intrusions and microsaccades in progressive supranuclear palsy
    Jorge Otero-Millan
    Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    J Neurosci 31:4379-87. 2011
    ..Furthermore, the loss of a vertical component in fixational saccades and SWJs was the eye movement feature that best distinguished PSP patients from controls...
  72. ncbi Target selection and the superior colliculus: goals, choices and hypotheses
    Richard J Krauzlis
    Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vision Res 44:1445-51. 2004
    ..However, recent studies have shown that the functions of the SC are not restricted to the motor control of saccades. The pattern of activity observed during multi-saccade movements, combined eye-head movements, and pursuit eye ..
  73. ncbi Microsaccades keep the eyes' balance during fixation
    Ralf Engbert
    Department of Psychology, University of Potsdam, PO Box 601553, 14415 Potsdam, Germany
    Psychol Sci 15:431-6. 2004
    ..Two types of these fixational eye movements are drift and microsaccades (small-amplitude saccades)...
  74. pmc The neural selection and control of saccades by the frontal eye field
    Jeffrey D Schall
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, 301 Wilson Hall, 111 21st Avenue South, Vanderbilt University, Nashville, TN 37203, USA
    Philos Trans R Soc Lond B Biol Sci 357:1073-82. 2002
    ..Certain neurons in the FEF signal the location of conspicuous or meaningful stimuli that may be the targets for saccades. Other neurons control whether and when the gaze shifts...
  75. pmc Temporal discounting of reward and the cost of time in motor control
    Reza Shadmehr
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 30:10507-16. 2010
    ..The hyperbolic cost of this delay not only accounts for kinematics of saccades in adults, it also accounts for the faster saccades of children, who temporally discount reward more steeply...
  76. ncbi The brainstem burst generator for saccadic eye movements: a modern synthesis
    Charles A Scudder
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Brain Res 142:439-62. 2002
    In the 16 years since we last summarized the behavior of the premotor elements that control saccades, research has revealed shortcomings in previous formulations of the control mechanisms of the brainstem saccadic burst generator...
  77. ncbi Microstimulation of the frontal eye field and its effects on covert spatial attention
    Tirin Moore
    Department of Psychology, Princeton University, Princeton, New Jersey 08544 1010, USA
    J Neurophysiol 91:152-62. 2004
    ..These results demonstrate that transient, but potent improvements in the deployment of covert spatial attention can be obtained by microstimulation of FEF sites from which saccadic eye movements are also evoked...
  78. ncbi Controlled movement processing: superior colliculus activity associated with countermanded saccades
    Martin Paré
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 23:6480-9. 2003
    ..contains neurons with activity patterns sufficient to control both the cancellation and the production of saccades. We used a countermanding task to manipulate the probability that, after the presentation of a stop signal, the ..
  79. ncbi Role of dopamine in the primate caudate nucleus in reward modulation of saccades
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 26:5360-9. 2006
    ..These results suggest that reward-dependent changes in saccadic eye movements depend partly on dopaminergic modulation of neuronal activity in the caudate nucleus...
  80. pmc Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans
    Jennifer E McDowell
    Departments of Psychology and Neuroscience, Bio Imaging Research Center, Psychology Building, University of Georgia, Athens, GA 30602, USA
    Brain Cogn 68:255-70. 2008
    ..The generation of simple visually guided saccades (redirections of gaze to a visual stimulus or pro-saccades) and more complex volitional saccades require similar ..
  81. ncbi A model of saccade generation based on parallel processing and competitive inhibition
    J M Findlay
    Centre for Vision and Visual Cognition, Department of Psychology, University of Durham, Durham DH1 3LE, England
    Behav Brain Sci 22:661-74; discussion 674-721. 1999
    ..The model accounts for a number of well-established phenomena in target-elicited saccades: the gap effect, express saccades, the remote distractor effect, and the global effect...
  82. ncbi Reward-predicting activity of dopamine and caudate neurons--a possible mechanism of motivational control of saccadic eye movement
    Reiko Kawagoe
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113 8421, Japan
    J Neurophysiol 91:1013-24. 2004
    ....
  83. ncbi Saccade target selection during visual search
    J M Findlay
    Department of Psychology, University of Durham, U K
    Vision Res 37:617-31. 1997
    ..Accurate saccades with short latencies were common but errors sometimes occurred and search for an "oddity" target, defined ..
  84. ncbi Selection and maintenance of saccade goals in the human frontal eye fields
    Clayton E Curtis
    Department of Psychology and Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurophysiol 95:3923-7. 2006
    ..The mechanism that the FEF uses to support spatial working memory is tied to the selection and prospective coding of saccade goals, whereas the role of the IPS may be more tied to retrospective coding of sensory representations...
  85. pmc Saccadic latency in Parkinson's disease correlates with executive function and brain atrophy, but not motor severity
    Robert Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Neurobiol Dis 43:79-85. 2011
    ..to saccadic control are affected by Parkinson's disease (PD) pathology and a relationship between abnormal saccades and cognitive features of PD has been suggested...
  86. ncbi The antisaccade: a review of basic research and clinical studies
    S Everling
    MRC Group in Sensory Motor Neuroscience, Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Neuropsychologia 36:885-99. 1998
    ..These findings are discussed and the potential of the antisaccade task for diagnostic purposes is evaluated...
  87. ncbi The use of the saccade target as a visual reference when localizing flashes during saccades
    Femke Maij
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University, Van der Boechorststraat 9, Amsterdam, The Netherlands
    J Vis 10:7.1-9. 2010
    ..In a second experiment, it disappeared at different moments. Both manipulations affected the mislocalization. We conclude that our subjects' judgments are partly based on the flashed dot's position relative to the saccade target...
  88. ncbi Initiation and inhibitory control of saccades with the progression of Parkinson's disease - changes in three major drives converging on the superior colliculus
    Yasuo Terao
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuropsychologia 49:1794-806. 2011
    ..PD patients were impaired not only in memory guided saccades, but also in visually guided saccades, beginning in the relatively early stages of the disease...
  89. ncbi Saccadic eye movements, schizotypy, and the role of neuroticism
    Ulrich Ettinger
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
    Biol Psychol 68:61-78. 2005
    ..We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms...
  90. pmc Free-flight odor tracking in Drosophila is consistent with an optimal intermittent scale-free search
    Andy M Reynolds
    Rothamsted Research, Harpenden, United Kingdom
    PLoS ONE 2:e354. 2007
    ..melanogaster) explore their landscape using a series of straight flight paths punctuated by rapid 90 degrees body-saccades [1]. Some saccades are triggered by visual expansion associated with collision avoidance...
  91. ncbi Microstimulation of the monkey superior colliculus induces pupil dilation without evoking saccades
    Chin An Wang
    Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Neurosci 32:3629-36. 2012
    ..The shared neural mechanisms suggest that pupil dilation may be associated with covert attention...
  92. ncbi From brainstem to cortex: computational models of saccade generation circuitry
    B Girard
    Laboratoire de Physiologie de la Perception et de l Action, UMR 7152, CNRS College de France, Paris, France
    Prog Neurobiol 77:215-51. 2005
    ..We present the various topics these models are concerned with: location of the feedback loop, multimodal saccades, long-term adaptation, on the fly trajectory correction, strategy and metrics selection, short-term spatial ..
  93. ncbi Mixing pro- and antisaccades in patients with parkinsonian syndromes
    S Rivaud-Pechoux
    Institut National de la Sante et de la Recherche Medicale, Boulevard de l Hopital, Paris, France
    Brain 130:256-64. 2007
    ..in blocks of randomly interleaved pro- and antisaccades). Saccade latencies and directional errors (misdirected saccades) were analysed in each subject, and we concentrated more specifically on the comparison of error rates in single ..
  94. pmc Examining the influence of task set on eye movements and fixations
    MARK MILLS
    Department of Psychology, University of Nebraska, Lincoln, NE 68588, USA
    J Vis 11:17. 2011
    ..g., fixation duration). Further, task set influenced the rate of change in fixation duration over the course of viewing but not saccade amplitude, suggesting independent mechanisms for control of these parameters...
  95. pmc Eye movement impairments in Parkinson's disease: possible role of extradopaminergic mechanisms
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    BMC Neurol 12:5. 2012
    ..However, the present study suggest that dopamine substitution is much less effective in improving oculomotor performance than it is in restoring skeletomotor abilities...
  96. ncbi The contribution of spatial remapping impairments to unilateral visual neglect
    Laure Pisella
    INSERM U534, Espace et Action, 16 Avenue Lepine, 69500 Bron, France
    Neurosci Biobehav Rev 28:181-200. 2004
    ..5). In a large part of the article, we seek to build our hypothesis based on this basic model and more speculative assumptions supported with extensive evidence from the literature...
  97. ncbi Global visual scanning abnormalities in schizophrenia and bipolar disorder
    Patricia E G Bestelmeyer
    School of Psychology, William Guild Building, University of Aberdeen, Aberdeen, AB24 2UB, UK
    Schizophr Res 87:212-22. 2006
    ..Spatial scanning characteristics but not temporal ones may serve as biomarkers in the functional psychoses...
  98. ncbi Target acceleration can be extracted and represented within the predictive drive to ocular pursuit
    Simon J Bennett
    Research Institute for Exercise and Sport Sciences, Liverpool John Moores University, Henry Cotton Campus, L3 2ET, Liverpool, UK
    J Neurophysiol 98:1405-14. 2007
    ..These results indicate that information on target acceleration can be extracted on-line, during pursuit of a visible ramp, and then used to drive a predictive oculomotor response in the absence of visual input...
  99. ncbi SWIFT: a dynamical model of saccade generation during reading
    Ralf Engbert
    Department of Psychology, University of Potsdam, Potsdam, Germany
    Psychol Rev 112:777-813. 2005
    ..They also present a mathematical analysis of the dynamics of the SWIFT model. Finally, within this framework, they present an analysis of the transition from parallel to serial processing...
  100. ncbi Postsaccadic target blanking prevents saccadic suppression of image displacement
    H Deubel
    Max Planck Institut für Psychologische Forschung, Münche, Germany
    Vision Res 36:985-96. 1996
    ..If it is not found, the assumption of stationarity of the world is broken and the system makes use of other information such as extraretinal signals for calibrating location...
  101. ncbi Antisaccades and task-switching: interactions in controlled processing
    Mariya V Cherkasova
    Department of Neurology, KS452, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Exp Brain Res 144:528-37. 2002
    ..In either case, the paradoxical benefit of task-switching for antisaccades challenges current models of task-switching...

Research Grants63

  1. FUNCTION OF MIDBRAIN STRUCTURES IN EYE MOVEMENT CONTROL
    DAVID WAITZMAN; Fiscal Year: 2005
    ..the velocity to position integrator which is essential in oculomotor feedback control should generate hypermetric saccades. 3)Determine if the map of saccade amplitude in the intermediate and deep layers of the SC is modified following ..
  2. Identification of genetic determinants of schizophrenia related phenotypes
    Dimitrios Avramopoulos; Fiscal Year: 2013
    ..with underlying latent factors reflecting common elements across tasks and two more phenotypes, the frequency of saccades in an eye fixation task, likely to reflect inhibition function similar to what is measured in the antisaccade ..
  3. Coding of Auditory Space in the Avian Brain
    JOSE L PENA; Fiscal Year: 2013
    ..are processed in parallel in order to control two output variables (horizontal and vertical coordinates of head saccades)...
  4. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2010
    ..to construct a unifying framework that explains the roles of the basal ganglia and the cerebellum in control of saccades and reaching...
  5. INVESTIGATION AND TREATMENT OF OCULAR MOTOR DISORDERS
    RICHARD JOHN LEIGH; Fiscal Year: 2012
    ..during the prior funding period: The first project concerns the beginning and ending of rapid eye movements (saccades)...
  6. Interaction of Visual and Oculomotor Signals in Cortex
    Tirin Moore; Fiscal Year: 2013
    ..In the second aim, we will use voluntarily generated saccades to pursue the relationship between saccade target selection and neural correlates of attention in visual cortex...
  7. Interaction of Visual and Oculomotor Signals in Cortex
    Tirin Moore; Fiscal Year: 2009
    ..In the second aim, we will use voluntarily generated saccades to pursue the relationship between saccade target selection and neural correlates of attention in visual cortex...
  8. Dynamic Basal Ganglia Saccade Networks
    Ann M Graybiel; Fiscal Year: 2010
    ..the substantia nigra pars reticulata which in turn projects to, and inhibits the superior colliculus and inhibits saccades thereby. This basal ganglia pathway is used as a prime example of the release functions of the basal ganglia...
  9. Motor unit diversity in horizontal eye movement control
    PAUL DOUGLAS GAMLIN; Fiscal Year: 2013
    ..other periods, it must control the extraocular muscles to move the eyes rapidly from one position to another (saccades), or track objects of interest at widely differing speeds (smooth pursuit), or precisely change the viewing angle ..
  10. STN Stimulation: Neural Control of Movement and Posture
    DANIEL MONTIE CORCOS; Fiscal Year: 2011
    ..2 will test the hypothesis that unilateral STN DBS can improve selected measures of performance of memory-guided saccades (Aim 2A) and memory guided movements (Aim 2B) more than bilateral STN DBS or being off STN DBS...
  11. Eye Movement Control in Normal Elderly and MCI
    Adam L Boxer; Fiscal Year: 2013
    ..Age-related changes occur in the brain network that controls saccades and covert shifts of attention, and the structure and function of this network are also highly sensitive to the ..
  12. Eye-Hand Coordination in Elderly Stroke Victims: A Visuomotor Rehab Study
    JOHN ROSS RIZZO; Fiscal Year: 2013
    ..During simple object retrieval tasks, eye movements or saccades are completed prior to arm movements or reaches...
  13. A neuronal process of the error signal that drives saccade adaptation
    Yoshiko Kojima; Fiscal Year: 2013
    ..We have approached our goal by using monkey saccadic eye movements, which provide an ideal model because saccades are precise, use only a few muscles, the associated brainstem neural circuit has been well documented and they ..
  14. Visual Motor Transformation in Cortex
    Lawrence H Snyder; Fiscal Year: 2012
    ..After each injection we will test animals on a panel of tasks (reaches, saccades and visual search) and then image the site of inactivation...
  15. 2013 Eye Movements: The Motor System that Sees the World GRC &GRS
    Michele A Basso; Fiscal Year: 2013
    ..or is it a shared mechanism? Do binocular disparity signals provide a low-level target selection mechanism for saccades or pursuit? Questions such as these are generating much excitement in the field and are producing results that ..
  16. Neural Basis of Saccade Preparation
    Neeraj J Gandhi; Fiscal Year: 2013
    ..The oculomotor repertoire is governed by alternating activity patterns in competing networks that generate saccades and preserve fixation...
  17. Role of oculomotor proprioception in spatial processing by the parietal cortex
    LINUS DASHIH SUN; Fiscal Year: 2013
    ..double-step task is a laboratory metaphor for this problem: monkeys and humans can make two sequentially accurate saccades to recently vanished stimuli despite the changing retinal position of the stimuli during the intervening saccade...
  18. Neural mechanism of sustained spatial attention across saccades
    ALEXANDRIA CONCETTA MARINO; Fiscal Year: 2013
    Natural visual exploration frequently employs fast ballistic eye movements (saccades) and covert visual attention...
  19. Neurophysiology of Saccade Adaptation
    Robijanto Soetedjo; Fiscal Year: 2013
    ..the first, we will inactivate the OMV pharmacologically and determine the deficit in the behavioral adaptation of saccades to an intra-saccadic target step, which causes saccades to appear inaccurate...
  20. The Neurophysiology of Spatial Vision
    Michael E Goldberg; Fiscal Year: 2013
    ..before an intervening eye movement, but they also slightly mislocalize saccade targets flashed immediately around saccades. Aim 3 is to study the spatial and temporal courses of the remapping process and the effects of inactivation of ..
  21. THE ROLE OF VESTIBULAR SIGNALS IN CORTICAL SPATIAL UPDATING
    ELIANA MIRA KLIER; Fiscal Year: 2012
    ..These shifting receptive fields allow one to keep track of the locations of objects in space across saccades. But do these remapping cells only maintain spatial constancy for intervening saccadic eye movements, or do they ..
  22. Visuomotor functions of ascending pathways to frontal cortex
    Marc A Sommer; Fiscal Year: 2010
    ..the functions of these ascending pathways? We showed previously that the SC-FEF pathway conveys feedback about saccades (corollary discharge), but relatively little is known about the SNr-FEF and DN-FEF pathways...
  23. Attention Allocation for Voluntary Smooth Eye Movements
    Stephen J Heinen; Fiscal Year: 2013
    ..We have evidence that peripheral motion improves pursuit by minimizing saccades, and that attention is not locked to the fovea, but can be allocated flexibly to the periphery when the foveal ..
  24. Is saccade adaptation driven by reinforcement?
    Jay A Edelman; Fiscal Year: 2013
    ..Because saccades are so brief, they cannot be guided by visual feedback, but must rely on feedback after each saccade to check the ..
  25. Control of saccades in health and disease
    Reza Shadmehr; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): It is commonly assumed that saccades are ballistic and stereotypical. Yet, there is structured variability in the motor commands that initiate a saccade to a target...
  26. Updating location information across object and eye movements
    JULIE GOLOMB GOLOMB; Fiscal Year: 2012
    ..trace" has been demonstrated for low-level spatial attention and discrimination of simple stimuli across saccades, but does it generalize to sustained representations of complex objects and actions? Aim 1 explores the ..
  27. Planning in parietal-frontal circuits
    Richard A Andersen; Fiscal Year: 2013
    ..If inactivation of these two areas produce a bias in the decision task (LIP for saccades and PRR for reaches), then these areas would be within the network for effector decision making...
  28. NEURAL VISUAL CODING: IMAGE TO OBJECT REPRESENTATION
    RUDIGER VON DER HEYDT; Fiscal Year: 2013
    ..One is that remapping of receptive fields, as classically observed in connection with saccades, should also occur in response to object movements...
  29. CEREBELLAR NUCLEI IN EYE MOVEMENT CONTROL AND ADAPTATION
    Farrel Robinson; Fiscal Year: 2003
    b>Saccades, smooth pursuit, and vergence need to be extremely accurate to provide clear vision...
  30. CORTICAL CONTRIBUTIONS TO THE CONTROL OF EYE MOVEMENTS
    Mark Segraves; Fiscal Year: 2004
    ..The FEF contains neurons whose firing is related to the generation of saccades, and projects to the superior colliculus as well as to other oculomotor regions of the brainstem...
  31. Saccade Target Selection Frontal Cortex
    Jeffrey D Schall; Fiscal Year: 2013
    ..stage that encodes and selects visual stimuli for attention followed by another stage that prepares to initiate saccades. This framework offers the opportunity to distinguish the respective contributions of these two, distinct stages ..
  32. FUNCTIONAL ORGANIZATION OF THE FRONTAL EYE FIELD
    Charles Bruce; Fiscal Year: 2003
    ..studies of neurons in the saccadic region of FEF (FEFsac) find different combinations of activity related to saccades, visual inputs, and eye position as well as to behavioral states including memory and anticipation; similar ..
  33. NEURONAL BASIS OF VISUAL PERCEPTION IN EYE MOVEMENTS
    Hitoshi Sato; Fiscal Year: 1991
    ..vermis was inconclusive in the literature until recently a small area in the posterior vermis was found to evoke saccades with very weak currents in the monkey...
  34. PROCESSES OF VISUAL TRACKING
    Martin Gizzi; Fiscal Year: 1993
    ..the nucleus of the optic tract (NOT) will be made to assess its role in the generation of OKN, smooth pursuit and saccades to moving targets...
  35. SMOOTH PURSUIT, SACCADES, AND FIXATION IN SCHIZOPHRENIA
    Lee Friedman; Fiscal Year: 1992
    ..rates of saccadic intrusion during ocular fixation? 8) Which of the three tracking tasks, and which variables, are most useful in the discrimination of patients with schizophrenia from patients with affective disorders or normal controls?..
  36. CRCNS: Ultra-rapid object localization: Shortcuts in the brain's visual hierarchy
    MAXIMILIAN K RIESENHUBER; Fiscal Year: 2013
    ..However, this "Standard Model" was recently challenged by behavioral demonstrations that reliable saccades to images containing animals were initiated as early as 120-130 ms after image onset, with even faster saccades ..
  37. CORTICAL CONTRIBUTIONS TO THE CONTROL OF EYE MOVEMENTS
    Mark Segraves; Fiscal Year: 1993
    ..Frontal eye field removal is detrimental to the initiation and performance of saccades in complex visuomotor tasks...
  38. VISUAL REARRANGEMENT AND NEURAL PLASTICITY
    CAROL PECK; Fiscal Year: 1992
    ..a. Do some tectal neurons signal gaze motor error when gaze saccades are made to auditory targets, regardless of whether the head is fixed or is free to move? b...
  39. Using saccadic asaptation to probe the coordinate system of parietal neurons
    Matthew H Phillips; Fiscal Year: 2010
    ..we place the visual target in the receptive field of a neuron so that the endpoint of the monkey's adapted saccades fall outside the neuron's receptive field...
  40. NEURAL MECHANISMS OF VERGENCE EYE MOVEMENTS
    LAWRENCE MAYS; Fiscal Year: 2000
    ..Shifts in gaze between objects at different distances from the observer usually involve a combination of saccades and vergence movements...
  41. MODULATION OF CORTICAL ACTIVITY BY EYE MOVEMENTS
    D Snodderly; Fiscal Year: 2002
    ..A major theme is the effects of the drifts and the small saccades of fixational eye movements...
  42. PREGENICULATE NUCLEUS IN VISUAL/OCULOMOTOR CONTROL
    Christine Livingston; Fiscal Year: 2000
    ..It is known that the generation, direction and control of saccades are mediated by various cortical, thalamic and brainstem structures; however the mechanisms by which saccades are ..
  43. CONTROL OF SACCADE SIZE BY CEREBELLAR NEURONS
    CHARLES SCUDDER; Fiscal Year: 2001
    ..term goal of this research is to determine how the brainstem and cerebellum collectively act to generate accurate saccades. The dorsal-posterior vermis of the cerebellum (lobules V-VII) and the fastigial nucleus are postulated to ..
  44. S CONE RESPONSES AND NEURAL PATHWAYS FOR ACCOMODATION
    FRANCES RUCKER; Fiscal Year: 2003
    ..in the process, the visual mechanisms that might mediate the signals (Stiles-Crawford effect and fixation micro-saccades), and the neural pathways and transmit the signals...
  45. STUDY OF OCULOMOTOR CONTROL SYSTEM
    David Robinson; Fiscal Year: 1993
    ..anal afferents are distributed over all directions as are the action directions of burst neurons that create saccades. These patterns can be accounted for with this learning network...
  46. Functional Organization of Extraocular Motoneurons
    Michael Jones; Fiscal Year: 2006
    ..motoneurons comprise the final common output pathway for all ocular behaviors, typically categorized as saccades, smooth pursuit, vergence, and the vestibuloocular (VOR) and optokinetic (OKR) reflexes...
  47. Feedback control of saccades
    Minnan Xu; Fiscal Year: 2009
    ..To solve this problem, I suggest that a better approach may be to consider control of saccades. These movements typically complete in 60ms and are too fast for external sensory feedback to be useful...
  48. Role of Parabigeminal Neucleus in Visuomotor Behavior
    Joseph Malpeli; Fiscal Year: 2007
    ..by applicant): Good vision requires an oculomotor system that can make rapid and accurate eye movements, called saccades, to visual targets of interest. To do this, the brain must have an internal representation of target location...
  49. CORTICAL CONTROL OF SUPERIOR COLLICULUS
    JAMES MC ILWAIN; Fiscal Year: 1993
    ..Previous work indicates that the directions and amplitudes of orienting saccades are encoded in the pattern of discharge of neurons spread over a large region of the deeper collicular laminae...
  50. Ocular and Manual Tracking of Visual Targets
    JOHN SOECHTING; Fiscal Year: 2004
    ..Normally, ocular tracking involves saccades as well as smooth pursuit...
  51. STRUCTURAL ORGANIZATION OF THE SUPERIOR COLLICULUS
    William Charles Hall; Fiscal Year: 2010
    ..saccadic eye movement is attenuated to prevent both perceptual blurring and the triggering of unwanted subsequent saccades. The model hypothesizes premotor cells located in the intermediate layer of the superior colliculus that command ..
  52. Gaze Control: Inactivation of Superior Colliculus
    Mark Walton; Fiscal Year: 2005
    ..Many studies have investigated the discharge of neurons in the deeper layers in association with saccades. These cells are characterized by high frequency bursts of spikes beginning roughly 20 ms before saccade onset...
  53. VISUAL DEVELOPMENT OF SENSORY AND MOTOR FUNCTIONS
    CLIFTON SCHOR; Fiscal Year: 2007
    ..The proposed experiments examine the processes by which subsystems such as vergence, smooth pursuit, and saccades interact to produce the requisite changes in binocular alignment...
  54. OCULOMOTOR RANGE IN HEALTH AND DISEASE
    John Stahl; Fiscal Year: 1999
    Rapid shifts of gaze can be accomplished either by movement of the eyes alone (eye saccades) or combined movements of eyes and head (eye-head saccades)...
  55. DEVELOPMENT OF fMRI COMPATIBLE REVERSIBLE DEACTIVATION
    STEPHEN LOMBER; Fiscal Year: 2005
    ..implant the device over a region of V1 in non-human primates that have been trained to make visually guided saccades. If V1 is successfully deactivated, saccades to targets within the scotoma should be abolished...
  56. Conditionng of Pyramidal Activity by Sensory Inflow
    John Schlag; Fiscal Year: 2003
    The long-term objective of this research is to study forebrain mechanisms responsible for the initiation of ocular saccades. During the present project period, the focus is on two aspects of saccade initiation: one is the mechanism by ..
  57. VISUOSPATIAL ATTENTION DYNAMICS & SACCADIC EYE MOVEMENTS
    Vera Maljkovic; Fiscal Year: 2004
    ..Experiments will quantitatively describe the mechanism of the attentional shift that accompanies saccades and use the resulting model to address some long-standing phenomena in the field...
  58. Mapping spatial working memory and attention in cortex
    Donald Hagler; Fiscal Year: 2004
    ..the function of these various brain regions in the working memory of spatial location and the generation of saccades, or rapid eye movements, toward those locations. There are three specific aims: 1...
  59. PARALLEL INFORMATION PROCESSING OF THE VISUAL SYSTEM
    Peter Schiller; Fiscal Year: 2002
    ..The proposed work has important clinical relevance as it will serve characterize the functions of various visual cortical areas. ..
  60. NEURAL CONTROL OF VISUALLY GUIDED EYE MOVEMENTS
    Peter Schiller; Fiscal Year: 2007
    ..abstract_text> ..
  61. The Role of Areas V1 and V2 in Target Selection
    Peter Schiller; Fiscal Year: 2008
    ..abstract_text> ..
  62. Phase Transition Models of Oculomotor Control
    Mark Shelhamer; Fiscal Year: 2003
    ..The research plan consists of three main efforts. First is the analysis of periodic saccades for evidence of multiple stable states, in analogy to the finger tapping work referred to above...
  63. Improved Search Coil Method for Measuring Eye Movements
    Mark Shelhamer; Fiscal Year: 2007
    ..abstract_text> ..