electroretinography

Summary

Summary: Recording of electric potentials in the retina after stimulation by light.

Top Publications

  1. ncbi Rodent electroretinography: methods for extraction and interpretation of rod and cone responses
    A E Weymouth
    The University of Melbourne, Department of Optometry and Vision Sciences, Parkville, Victoria 3010, Australia
    Prog Retin Eye Res 27:1-44. 2008
  2. doi The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Ophthalmol 127:297-302. 2009
  3. pmc Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse
    T K Park
    Section for Translational Research in Retinal and Macular Degeneration, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Gene Ther 16:916-26. 2009
  4. pmc Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
    Deniz Dalkara
    Department of Chemical Engineering, The University of California at Berkeley, Berkeley, California 94720 3190, USA
    Mol Ther 17:2096-102. 2009
  5. pmc TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    INSERM, UMR_S968, F 75012, Paris, France
    Am J Hum Genet 85:720-9. 2009
  6. doi ISCEV Standard for full-field clinical electroretinography (2008 update)
    M F Marmor
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA
    Doc Ophthalmol 118:69-77. 2009
  7. ncbi Retinal degeneration mutants in the mouse
    B Chang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    Vision Res 42:517-25. 2002
  8. ncbi Effective gene therapy with nonintegrating lentiviral vectors
    Rafael J Yáñez-Muñoz
    Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nat Med 12:348-53. 2006
  9. ncbi Morphological and functional retinal impairment in Alzheimer's disease patients
    V Parisi
    Clinica Oculistica Università di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 112:1860-7. 2001
  10. ncbi The relationship between opsin overexpression and photoreceptor degeneration
    E Tan
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Invest Ophthalmol Vis Sci 42:589-600. 2001

Detail Information

Publications377 found, 100 shown here

  1. ncbi Rodent electroretinography: methods for extraction and interpretation of rod and cone responses
    A E Weymouth
    The University of Melbourne, Department of Optometry and Vision Sciences, Parkville, Victoria 3010, Australia
    Prog Retin Eye Res 27:1-44. 2008
    ..The guidelines presented here are applicable to a wide range of investigations of retinal disease in rodent models...
  2. doi The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Ophthalmol 127:297-302. 2009
    ..To evaluate the involvement of NR2E3 in inherited retinal degenerative diseases in the Israeli and Palestinian populations and to study phenotypic variability in patients who are homozygous for the same mutation...
  3. pmc Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse
    T K Park
    Section for Translational Research in Retinal and Macular Degeneration, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Gene Ther 16:916-26. 2009
    ..No off-target expression was observed. Rs1-KO mice treated with this vector showed a decrease in the schisis cavities and had improved retinal signaling evaluated by recording the electroretinogram 11-15 weeks after the application...
  4. pmc Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
    Deniz Dalkara
    Department of Chemical Engineering, The University of California at Berkeley, Berkeley, California 94720 3190, USA
    Mol Ther 17:2096-102. 2009
    ..These findings may help avoid limitations, risks, and damage associated with subretinal injections currently necessary for clinical gene therapy...
  5. pmc TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    INSERM, UMR_S968, F 75012, Paris, France
    Am J Hum Genet 85:720-9. 2009
    ..autosomal-recessive congenital stationary night blindness (CSNB) and can be assessed by standard full-field electroretinography (ERG), showing severely reduced rod b-wave amplitude and slightly altered cone responses...
  6. doi ISCEV Standard for full-field clinical electroretinography (2008 update)
    M F Marmor
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA
    Doc Ophthalmol 118:69-77. 2009
    ..Clinical Electrophysiology of Vision (ISCEV), presents an updated and revised ISCEV Standard for clinical electroretinography (ERG)...
  7. ncbi Retinal degeneration mutants in the mouse
    B Chang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    Vision Res 42:517-25. 2002
    ..Through ophthalmoscopy, electroretinography and histology, we have discovered disorders affecting all aspects of the eye including the lid, cornea, ..
  8. ncbi Effective gene therapy with nonintegrating lentiviral vectors
    Rafael J Yáñez-Muñoz
    Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nat Med 12:348-53. 2006
    ..For therapeutic application to postmitotic tissues, this system substantially reduces the risk of insertional mutagenesis...
  9. ncbi Morphological and functional retinal impairment in Alzheimer's disease patients
    V Parisi
    Clinica Oculistica Università di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 112:1860-7. 2001
    ....
  10. ncbi The relationship between opsin overexpression and photoreceptor degeneration
    E Tan
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Invest Ophthalmol Vis Sci 42:589-600. 2001
    ..To characterize the process by which overexpression of normal opsin leads to photoreceptor degeneration...
  11. pmc Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study
    Claudia Gargini
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, 56100 Pisa, Italy
    J Comp Neurol 500:222-38. 2007
    ..However, an overall slower decay of retinal structure and function predicts that rd10 mice might become excellent models for rescue approaches...
  12. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    ..protect against insults to axons, strongly protects against DBA/2J glaucoma and preserves RGC activity as measured by pattern electroretinography. These experiments provide strong evidence for a local insult to axons in the optic nerve.
  13. doi Late histological and functional changes in the P23H rat retina after photoreceptor loss
    Bogdan Kolomiets
    INSERM, UMR_S968, Institut de la Vision, F 75012, Paris
    Neurobiol Dis 38:47-58. 2010
    ....
  14. pmc Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa
    Ji Jing Pang
    Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Ther 19:234-42. 2011
    ..These results lay the groundwork for the development of PDEβ-RP gene therapy trial and suggest that tyrosine-capsid mutant AAV vectors may be effective for treating other rapidly degenerating models of retinal degeneration...
  15. doi ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition)
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY, USA
    Doc Ophthalmol 124:1-13. 2012
    ..Standards for performance of the basic clinical mfERG test with a stimulus array of 61 or 103 hexagons, as well as for reporting the results, are specified...
  16. pmc Identification of a 2 Mb human ortholog of Drosophila eyes shut/spacemaker that is mutated in patients with retinitis pigmentosa
    Rob W J Collin
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    Am J Hum Genet 83:594-603. 2008
    ..With a size of 2 Mb, it is one of the largest human genes, and it is by far the largest retinal dystrophy gene. The discovery of EYS might shed light on a critical component of photoreceptor morphogenesis...
  17. pmc B-wave of the electroretinogram. A reflection of ON bipolar cell activity
    R A Stockton
    Department of Biophysical Sciences, State University of New York, School of Medicine, Buffalo 14214
    J Gen Physiol 93:101-22. 1989
    ....
  18. pmc TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells
    Catherine W Morgans
    Department of Ophthalmology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:19174-8. 2009
    ..Identification of TRPM1 as a mGluR6-coupled cation channel reveals a key step in vision, expands the role of the TRP channel family in sensory perception, and presents insights into the evolution of vertebrate vision...
  19. ncbi The gradient of retinal functional changes during acute intraocular pressure elevation
    Bang V Bui
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 46:202-13. 2005
    ..To characterize retinal function during a period of acutely elevated intraocular pressure (IOP) across a wide range of IOPs, including those typically observed in animals with experimental glaucoma...
  20. ncbi Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage
    Balwantray C Chauhan
    Laboratory for Retina and Optic Nerve, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 43:2969-76. 2002
    ..To characterize the effect of intraocular pressure (IOP) on optic disc topography, retinal function, and axonal survival in a model of IOP-induced optic nerve damage in rat...
  21. pmc The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses
    Bo Chang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Vis Neurosci 23:11-24. 2006
    ..Further, the nob2 mouse represents a model system in which to define the signals that guide synapse formation and/or maintenance in the OPL...
  22. ncbi Separation of receptor and lamina potentials in the electroretinogram of normal and mutant Drosophila
    M Heisenberg
    J Exp Biol 55:85-100. 1971
  23. pmc The scotopic threshold response of the dark-adapted electroretinogram of the mouse
    Shannon M Saszik
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    J Physiol 543:899-916. 2002
    ..These results support the use of the mouse ERG in studies of proximal retinal function...
  24. pmc Mutations in TRPM1 are a common cause of complete congenital stationary night blindness
    Maria M van Genderen
    Bartiméus, Institute for the Visually Impaired, 3702 AD Zeist, The Netherlands
    Am J Hum Genet 85:730-6. 2009
    ..Finally, we showed that detailed electroretinography is an effective way to discriminate among patients with mutations in either TRPM1 or GRM6, another ..
  25. pmc Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene
    B Chang
    The Jackson Laboratory, Bar Harbor, ME, USA
    Vision Res 47:624-33. 2007
    ..It may also provide a better model for experimental pharmaceutical-based therapy for RP because of its later onset and milder retinal degeneration than rd1 and nmf137...
  26. pmc Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene
    Prateek K Buch
    University College London Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 6:e18089. 2011
    ..progression in this novel mouse model of cone dystrophy was determined by a variety of techniques including electroretinography (ERG), retinal histology, immunohistochemistry and measurement of cGMP levels...
  27. pmc Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    Am J Hum Genet 90:321-30. 2012
    ..Interestingly, Gpr179 was highly concentrated in horizontal cells and Müller cell endfeet. The involvement of these cells in cCSNB and the specific function of GPR179 remain to be elucidated...
  28. pmc Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1
    Sabine Hüttl
    Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, D 81377 Munchen, Germany
    J Neurosci 25:130-8. 2005
    ..Our results show that CNGB1 is a crucial determinant of native CNG channel targeting. As a result of the lack of rod CNG channels, CNGB1-/- mice develop a retinal degeneration that resembles human retinitis pigmentosa...
  29. doi Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
    ..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
  30. pmc A recurrent mutation in GUCY2D associated with autosomal dominant cone dystrophy in a Chinese family
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, China
    Mol Vis 17:3271-8. 2011
    ..To identify the genetic locus and mutation responsible for autosomal dominant cone dystrophy (adCOD) in a large Chinese family and to describe the phenotypes of the patients...
  31. pmc Acute hypoglycemia decreases central retinal function in the human eye
    Mukhtar I Khan
    SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Vision Res 51:1623-6. 2011
    ..The association between low blood glucose levels and impaired central vision underscores the importance of avoiding when possible and promptly treating hypoglycemia, particularly in individuals with diabetes...
  32. doi Post-receptoral contributions to the rat scotopic electroretinogram a-wave
    Trung M Dang
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Australia
    Doc Ophthalmol 122:149-56. 2011
    ..Second, OFF-pathway inhibition removed a corneal negativity that resides between the a-wave trough and the b-wave onset...
  33. ncbi Pharmacological studies of the mouse cone electroretinogram
    Sumit Sharma
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44106, USA
    Vis Neurosci 22:631-6. 2005
    b>Electroretinography provides a useful noninvasive approach to evaluate cone pathway activity...
  34. ncbi XIAP-mediated neuroprotection in retinal ischemia
    J Renwick
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Gene Ther 13:339-47. 2006
    ..Thus, XIAP-mediated gene therapy imparts both functional and structural protection to the retina after a transient ischemic episode...
  35. ncbi Intraocular CNTF reduces vision in normal rats in a dose-dependent manner
    Trevor J McGill
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    Invest Ophthalmol Vis Sci 48:5756-66. 2007
    ..CNTF is a neuroprotective agent for retinal degenerations that can cause reduced electroretinogram (ERG) amplitudes. The goal of the present study was to determine the effects of intraocular delivery of CNTF on normal rat visual function...
  36. pmc Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis
    Xia Li
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 52:7-15. 2011
    ..A prior study showed that AAV-mediated RPE65 expression can prevent early cone degeneration. The present study was conducted to test whether the remaining cones in older rd12 mice can be rescued...
  37. pmc Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model
    Tomas S Aleman
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 52:6898-910. 2011
    ..To investigate the human disease due to CRB1 mutations and compare results with the Crb1-mutant rd8 mouse...
  38. ncbi A high association with cone dystrophy in Fundus albipunctatus caused by mutations of the RDH5 gene
    M Nakamura
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Invest Ophthalmol Vis Sci 41:3925-32. 2000
    ....
  39. pmc Functional photoreceptor loss revealed with adaptive optics: an alternate cause of color blindness
    Joseph Carroll
    Center for Visual Science, University of Rochester, Rochester, NY 14627 0270, USA
    Proc Natl Acad Sci U S A 101:8461-6. 2004
    ..We confirm that remarkably, this loss of one-third of the cones does not impair any aspect of vision other than color...
  40. doi Fundus albipunctatus associated with compound heterozygous mutations in RPE65
    Patrik Schatz
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Ophthalmology 118:888-94. 2011
    ..To describe a family with an 18-year-old woman with fundus albipunctatus and compound heterozygous mutations in RPE65 whose unaffected parents and 1 female sibling harbored single heterozygous RPE65 mutations...
  41. doi Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 119:819-26. 2012
    ..To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD)...
  42. ncbi A novel Gly35Ser mutation in the RDH5 gene in a Japanese family with fundus albipunctatus associated with cone dystrophy
    Y Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Arch Ophthalmol 119:1059-63. 2001
    ..To assess the clinical and genetic characteristics of a Japanese family with fundus albipunctatus with progressive cone dystrophy associated with a mutation in the RDH5 gene...
  43. pmc Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy
    David M Sherry
    Department of Cell Biology, University of Oklahoma Health Sciences Center, BMSB 781, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Eur J Neurosci 32:1461-72. 2010
    ....
  44. pmc Age-related retinopathy in NRF2-deficient mice
    Zhenyang Zhao
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19456. 2011
    ..The purposes of this study were to determine whether NRF2-deficient mice would develop AMD-like retinal pathology with aging and to explore the underlying mechanisms...
  45. pmc Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans
    Zheng Li
    University College London UCL Institute of Ophthalmology, London EC1V 9EL, UK
    Am J Hum Genet 85:711-9. 2009
    ..These findings suggest an important role of this specific cation channel for the normal function of ON bipolar cells in the human retina...
  46. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011
    ..To study cone photoreceptor structure and function in patients with inherited retinal degenerations treated with sustained-release ciliary neurotrophic factor (CNTF)...
  47. ncbi Phenotype of autosomal dominant cone-rod dystrophy due to the R838C mutation of the GUCY2D gene encoding retinal guanylate cyclase-1
    M Smith
    Department of Ophthalmology, Torbay Hospital, Torquay, Devon, UK
    Eye (Lond) 21:1220-5. 2007
    ..To describe the phenotype of members of a large Caucasian British family affected by autosomal dominant cone-rod dystrophy due to an R838C mutation in the guanylate cyclase 2D (GUCY2D) gene encoding retinal guanylate cyclase-1 (RETGC-1)...
  48. pmc Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration
    J Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
    Br J Ophthalmol 85:287-90. 2001
    ....
  49. ncbi Assessing retinal function with the multifocal technique
    D C Hood
    Department of Psychology, Columbia University, 116th and Broadway, NY 10027 7004, New York, USA
    Prog Retin Eye Res 19:607-46. 2000
    ..It is speculated that a markedly diminished second-order kernel is diagnostic of outer plexiform layer damage, not inner plexiform layer damage as is commonly assumed...
  50. ncbi Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy
    Yuko Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Am J Ophthalmol 139:894-9. 2005
    ..To describe the clinical and genetic characteristics of six Japanese families with Bietti's crystalline corneoretinal dystrophy (BCD)...
  51. ncbi GABAC receptor-mediated inhibition in the retina
    Peter D Lukasiewicz
    Department of Ophthalmology, Washington University School of Medicine, Campus Box 8096, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Vision Res 44:3289-96. 2004
    ..These data suggest that GABAC receptors determine the time course and extent of inhibition at bipolar cell terminals that, in turn, modulates the magnitude of excitatory transmission from bipolar cells to ganglion cells...
  52. ncbi Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration
    D A Thompson
    Departments of Ophthalmology and Visual Sciences and Biological Chemistry, University of Michigan Medical School, Ann Arbor, USA
    Invest Ophthalmol Vis Sci 41:4293-9. 2000
    ..To characterize the spectrum of RPE65 mutations present in 453 patients with retinal dystrophy with an interest in understanding the range of functional deficits attributable to sequence variants in this gene...
  53. pmc Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa
    James W Kijas
    James A Baker Institute for Animal Health, Cornell University, 47 Hungerford Hill Road, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 99:6328-33. 2002
    ..The RHO mutant dog also becomes the large animal needed for preclinical trials of therapies for a major subset of human retinopathies...
  54. pmc In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function
    Stacey S Choi
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento 95817, USA
    Invest Ophthalmol Vis Sci 47:2080-92. 2006
    ..To relate in vivo microscopic retinal changes to visual function in patients who have various forms of retinal dystrophy...
  55. doi Early inner retinal dysfunction in streptozotocin-induced diabetic rats
    Kenichi Kohzaki
    Department of Ophthalmology, The Jikei University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:3595-604. 2008
    ..However, the effect that diabetes has on other ganglion cell-related responses is not known. This study was a systematic evaluation of streptozotocin (STZ) diabetes-related ERG changes in rats for the first 11 weeks after diabetogenesis...
  56. pmc Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina
    Gauri P Misra
    Department of Pharmaceutical Sciences, School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Philadelphia, PA 19107, USA
    Biomaterials 30:6541-7. 2009
    ..to the retina based on hematoxylin and eosin stain, immunostaining for microglial cell activation, and electroretinography. These subconjunctivally implantable hydrogels have potential for long-term periocular delivery of insulin ..
  57. ncbi Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
    R M Petters
    Department of Animal Science, North Carolina State University, Raleigh, USA
    Nat Biotechnol 15:965-70. 1997
    ..Given the strong similarities in phenotype to that of RP patients, these transgenic pigs will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials...
  58. doi Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds
    Sandra Brunner
    Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Invest Ophthalmol Vis Sci 51:1106-15. 2010
    ..To establish mouse models for RPGR-associated diseases by generating and characterizing an Rpgr mutation (in-frame deletion of exon 4) in two different genetic backgrounds (BL/6 and BALB/c)...
  59. pmc Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene
    Jiangang Gao
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:5698-703. 2002
    ..The phenotype of Rp1 mutant mice resembles the human RP1 disease. Thus, these mice provide a useful model for studies of RP1 function, disease pathology, and therapeutic interventions...
  60. pmc Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse
    Shannon E Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e11306. 2010
    ..The purpose of this study was to test whether delivery of functional GC1 to cone cells of the postnatal GC1KO mouse could restore function to these cells...
  61. ncbi GABAc feedback pathway modulates the amplitude and kinetics of ERG b-wave in a mammalian retina in vivo
    Cun Jian Dong
    Department of Biological Sciences, Allergan Pharmaceuticals, RD 2C Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Vision Res 42:1081-7. 2002
    ..Our results also provide functional evidence that the feedback may be involved in temporal processing in the mammalian retina...
  62. doi Quantification of ischemic damage in the rat retina: a comparative study using evoked potentials, electroretinography, and histology
    Thomas Jehle
    University Eye Hospital Freiburg, Freiburg, Germany
    Invest Ophthalmol Vis Sci 49:1056-64. 2008
    ..The impact of ocular ischemia on luminance and frequency-modulated contrast vision was compared with the function of outer retinal cells and the number of intact retinal ganglion cells (RGCs)...
  63. ncbi Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse
    Lauren L Daniele
    F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Invest Ophthalmol Vis Sci 46:2156-67. 2005
    ..To test the hypothesis that Nrl(-)(/)(-) photoreceptors are cones, by comparing them with WT rods and cones using morphological, molecular, histochemical, and electrophysiological criteria...
  64. pmc AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation
    Ji Jing Pang
    Departments of Ophthalmology, University of Florida, Gainesville, Florida 32610, USA
    Invest Ophthalmol Vis Sci 49:4278-83. 2008
    ..To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the beta-subunit of rod photoreceptor cGMP phosphodiesterase...
  65. pmc The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
    Wolfgang Baehr
    Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 282:8837-47. 2007
    ..We interpret these results to demonstrate an intrinsic requirement of GCs for stability and/or transport of a set of membrane-associated phototransduction proteins...
  66. ncbi Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal
    Baerbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charleston, 29425, USA
    Invest Ophthalmol Vis Sci 46:3876-82. 2005
    ..This study was designed to investigate the feasibility of restoring functional cones with exogenous 11-cis retinal...
  67. ncbi SOD2 knockdown mouse model of early AMD
    Verline Justilien
    Department of Molecular Genetics, University of Florida, Gainesville, Florida, USA
    Invest Ophthalmol Vis Sci 48:4407-20. 2007
    ..To test the hypothesis that oxidative injury to the retinal pigment epithelium (RPE) may lead to retinal damage similar to that associated with the early stages of age-related macular degeneration (AMD)...
  68. doi Morphologic photoreceptor abnormality in occult macular dystrophy on spectral-domain optical coherence tomography
    Sang Jun Park
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
    Invest Ophthalmol Vis Sci 51:3673-9. 2010
    ..an ophthalmic evaluation, which included a fundus examination, fluorescein angiography, full-field electroretinography (ERG), multifocal ERG, time-domain optical coherence tomography (TD-OCT), and visual field testing...
  69. ncbi Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses
    Eliot L Berson
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Arch Ophthalmol 122:1306-14. 2004
    ..To determine whether docosahexaenoic acid will slow the course of retinal degeneration in subgroups of patients with retinitis pigmentosa who are receiving vitamin A...
  70. ncbi Evaluation of the rhodopsin knockout mouse as a model of pure cone function
    G B Jaissle
    Department II, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 42:506-13. 2001
    ..To determine a time window in the rhodopsin knockout (Rho(-/-)) mouse during which retinal function is already sufficiently developed but cone degeneration is not yet substantial, thus representing an all-cone retina...
  71. ncbi Mutant rhodopsin transgene expression on a null background
    J M Frederick
    John A Moran Eye Center, University of Utah Health Science Center, 50 North Medical Drive, Salt Lake City, UT 04132, USA
    Invest Ophthalmol Vis Sci 42:826-33. 2001
    ..To study mechanisms leading to photoreceptor degeneration in mouse models for autosomal dominant retinitis pigmentosa (adRP) based on the rhodopsin P23H mutation...
  72. pmc Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration
    N J Colley
    Department of Biology, University of California at San Diego, La Jolla 92093 0649, USA
    Proc Natl Acad Sci U S A 92:3070-4. 1995
    ..We demonstrate that retinal degeneration results from interference in the maturation of wild-type rhodopsin by the mutant proteins...
  73. ncbi New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis
    M W Seeliger
    Retinal Electrodiagnostics Research Group, Department of Ophthalmology, University of Tubingen, Germany
    Nat Genet 29:70-4. 2001
    ..In general, the dissection of pathophysiological processes in animal models through the introduction of additional, selective mutations is a promising concept in functional genetics...
  74. ncbi Retinopathy induced in mice by targeted disruption of the rhodopsin gene
    M M Humphries
    Wellcome Ocular Genetics Unit, Genetics Department, Trinity College, Dublin, Ireland
    Nat Genet 15:216-9. 1997
    ....
  75. ncbi Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis
    M W Seeliger
    University Eye Hospital, Department II, Tubingen, Germany
    Invest Ophthalmol Vis Sci 40:3-11. 1999
    ..To describe the phenotype caused by a retinol deficiency in a family with compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP)...
  76. pmc Visual insignificance of the foveal pit: reassessment of foveal hypoplasia as fovea plana
    Michael F Marmor
    Department of Ophthalmology, Stanford University Medical Center, 300 Pasteur Dr, Room A 157, Stanford, CA 94305 5308, USA
    Arch Ophthalmol 126:907-13. 2008
    ..To elucidate the visual significance of the foveal pit by measuring foveal architecture and function and to reassess use of the term foveal hypoplasia (as visual acuity can vary among patients who lack a pit)...
  77. pmc RP2 and RPGR mutations and clinical correlations in patients with X-linked retinitis pigmentosa
    Dror Sharon
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Am J Hum Genet 73:1131-46. 2003
    ..Furthermore, as the length of the abnormal amino acid sequence following ORF15 frameshift mutations increased, the severity of disease increased...
  78. ncbi The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurity
    Kegao Liu
    Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 47:2639-47. 2006
    ..In a rat model of retinopathy of prematurity (ROP), the retinal vasculature and function of the neural retina were studied longitudinally. Vascular and neural parameters were evaluated for significant relationships...
  79. ncbi Regulation of rod phototransduction machinery by ciliary neurotrophic factor
    Rong Wen
    Department of Ophthalmology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:13523-30. 2006
    ..Whether CNTF-induced changes in rods are through the same mechanism that mediates light-induced photoreceptor plasticity remains to be answered...
  80. pmc Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindness
    Ronald G Gregg
    Department of Biochemistry and Molecular Biology, University of Louisville, KY 40202, USA
    J Neurophysiol 98:3023-33. 2007
    ..Together, our data show that nyctalopin expression on DBC dendrites is required for normal function of the murine retina...
  81. doi Age-related retinal function changes in albino and pigmented rats
    Jason Charng
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
    Invest Ophthalmol Vis Sci 52:8891-9. 2011
    ..To investigate the effect of old age (3 vs. 18 months) on the retinal function of albino (Sprague-Dawley [SD]) and pigmented (Long-Evans [LE]) rats...
  82. ncbi Characterization of the rod photoresponse isolated from the dark-adapted primate ERG
    J A Jamison
    W.K. Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Vis Neurosci 18:445-55. 2001
    ....
  83. ncbi Neuroprotective effect of hepatocyte growth factor against photoreceptor degeneration in rats
    Shigeki Machida
    Department of Ophthalmology, Iwate Medical University School of Medicine, Iwate, Japan
    Invest Ophthalmol Vis Sci 45:4174-82. 2004
    ..To determine whether hepatocyte growth factor (HGF) has a neuroprotective effect against photoreceptor degeneration in rats...
  84. ncbi Young monozygotic twin sisters with fundus albipunctatus and cone dystrophy
    Makoto Nakamura
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Arch Ophthalmol 122:1203-7. 2004
    ....
  85. ncbi Anesthesia can cause sustained hyperglycemia in C57/BL6J mice
    E T Brown
    Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Vis Neurosci 22:615-8. 2005
    ..The choice of anesthesia may also be important in diabetes and metabolism research where changes in blood glucose could impact physiological processes...
  86. ncbi Novel dominant rhodopsin mutation triggers two mechanisms of retinal degeneration and photoreceptor desensitization
    Roustem Iakhine
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556 0369, USA
    J Neurosci 24:2516-26. 2004
    ..Such a combination of multiple pathological pathways resulting from a single mutation may underlie several dominant retinal diseases in humans...
  87. pmc Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal
    Akiko Maeda
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Invest Ophthalmol Vis Sci 47:4540-6. 2006
    ..To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore...
  88. pmc Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina
    P Kofuji
    Departments of Neuroscience and Physiology, University of Minnesota, Minneapolis 55455, USA
    J Neurosci 20:5733-40. 2000
    ..The highly regulated localization and the functional properties of Kir4.1 in Müller cells suggest the involvement of this channel in the regulation of extracellular K(+) in the mouse retina...
  89. pmc Calmodulin binding to Drosophila NinaC required for termination of phototransduction
    J A Porter
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    EMBO J 14:4450-9. 1995
    ..These results suggest that calmodulin binding to both C1 and C2 is required in vivo for termination of phototransduction...
  90. pmc Human cone photoreceptor responses measured by the electroretinogram [correction of electoretinogram] a-wave during and after exposure to intense illumination
    A A Paupoo
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 529:469-82. 2000
    ..5 min after a near-total bleach. This time course is very similar to previous measurements of the regeneration of cone photopigment, and it seems highly probable that the reduction in dim-flash sensitivity results from pigment depletion...
  91. ncbi Phenotypes of trpl mutants and interactions between the transient receptor potential (TRP) and TRP-like channels in Drosophila
    H T Leung
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907 1392, USA
    J Neurosci 20:6797-803. 2000
    ..Two lines of evidence are presented to suggest that, in addition to the interaction proposed by Reuss et al. (1997), there are other forms of interactions between TRP and TRPL channels, probably involving the channel proteins themselves...
  92. ncbi Macular dystrophy in a Japanese family with fundus albipunctatus
    Kazuki Hotta
    Department of Ophthalmology, Kameda Medical Center, Kamogowa, Japan
    Am J Ophthalmol 135:917-9. 2003
    ..To report a Japanese family with fundus albipunctatus and macular dystrophy associated with a mutation in the 11-cis retinol dehydrogenase (RDH5) gene...
  93. doi Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease
    Abrez Hussain Batcha
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville 3010, Victoria, Australia
    Neurobiol Dis 45:887-96. 2012
    ..As retinal structure and connectivity are well characterised, the retina may provide a useful model tissue in which to characterise the mechanisms important in the development of neuronal pathology in HD...
  94. ncbi Fundus albipunctatus in a 6-year old girl due to compound heterozygous mutations in the RDH5 gene
    Alessandro Iannaccone
    Retinal Degeneration and Ophthalmic Genetics Service, Hamilton Eye Institute, Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 731, Memphis, TN 38163, USA
    Doc Ophthalmol 115:111-6. 2007
    ..American female with a clinical presentation suggestive of FA underwent dark-adapted full-field flash electroretinography (ERG) at 30 and 120 min. The pattern of ERG abnormalities was consistent with the working diagnosis FA...
  95. pmc Functional and morphological effects of laser-induced ocular hypertension in retinas of adult albino Swiss mice
    Manuel Salinas-Navarro
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:2578-98. 2009
    ..To investigate the effects of laser photocoagulation (LP)-induced ocular hypertension (OHT) on the survival and retrograde axonal transport of retinal ganglion cells (RGC), as well as on the function of retinal layers...
  96. pmc Retinal dysfunction and refractive errors: an electrophysiological study of children
    D I Flitcroft
    Department of Ophthalmology, The Children s University Hospital, Temple Street, Dublin D1, Ireland
    Br J Ophthalmol 89:484-8. 2005
    ..To evaluate the relation between refractive error and electrophysiological retinal abnormalities in children referred for investigation of reduced vision...
  97. ncbi Clinical phenotype in a Swedish family with a mutation in the IMPDH1 gene
    Patrik Schatz
    Department of Ophthalmology, Lund University Hospital, Lund, Sweden
    Ophthalmic Genet 26:119-24. 2005
    ..Aiming towards an understanding of the molecular background of retinitis pigmentosa, this paper describes the phenotype of a Swedish family with a mutation in IMPDH1...
  98. ncbi Novel triple missense mutations of GUCY2D gene in Japanese family with cone-rod dystrophy: possible use of genotyping microarray
    Shigeo Yoshida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Vis 12:1558-64. 2006
    ..To report a novel mutation in the GUCY2D gene in a Japanese family with autosomal dominant cone-rod dystrophy (adCORD), and to examine the possible use of arrayed primer extension (APEX)-based genotyping chip in detecting mutations...
  99. ncbi Luminance dependence of neural components that underlies the primate photopic electroretinogram
    Shinji Ueno
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Invest Ophthalmol Vis Sci 45:1033-40. 2004
    ..The purpose of this study was to determine the mechanism underlying this unusual phenomenon...
  100. pmc Functions of the two glutamate transporters GLAST and GLT-1 in the retina
    T Harada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 95:4663-6. 1998
    ..These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina...
  101. doi Light responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene
    Gabriel C Knop
    Institut für Neurowissenschaften und Biophysik, Forschungszentrum Julich, Leo Brandt Strasse, D 52425 Julich, Germany
    Eur J Neurosci 28:2221-30. 2008
    ..Our data suggest that in visual information processing, shortening and shaping of light responses by activation of HCN1 at the level of the photoreceptors is an important step in both scotopic and photopic pathways...

Research Grants75

  1. Airborne Nanoparticles for Therapeutic Applications
    Amir Naqwi; Fiscal Year: 2007
    ..Safety of the treatment will be established on the basis of retinal imaging, electroretinography and histopathology...
  2. Axonal cytoskeletal changes in experimental glaucoma
    Brad Fortune; Fiscal Year: 2010
    ..structural testing for Aim 1, RGC function will also be assessed in both eyes using three proven forms of electroretinography (Aim 3)...
  3. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..Retinal function will be determined by electroretinography. We currently have large colonies of both the tubby and the Trx-tubby mice and will be able to complete the ..
  4. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..Third, we will turn to functional assays using computerized pupillometry and electroretinography (ERG) to determine the ability of transplanted MSCs and locally released neurotrophic factors to restore ..
  5. Retinal degeneration caused by alterations in protein O-sulfation
    Muayyad R Al Ubaidi; Fiscal Year: 2010
    ..these mice demonstrate a slow retinal degeneration characterized by a gradual loss of scotopic and photopic electroretinography (ERGs) that become very apparent at 4 months of age (-30% loss)...
  6. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    James McGinnis; Fiscal Year: 2009
    ..Retinal function will be determined by electroretinography. We currently have large colonies of both the tubby and the Trx-tubby mice and will be able to complete the ..
  7. Unfolded Protein Response as a Therapeutic Target for ADRP Animal Models
    Marina Gorbatyuk; Fiscal Year: 2010
    ..We will monitor survival of photoreceptors using electroretinography and morphometry and will measure the activation of the ER stress and apoptosis using specific antibodies ..
  8. RECOVERY OF PHOTOTRANSDUCTION
    Ching Kang Chen; Fiscal Year: 2006
    ..Paired-flash" analyses of cone-derived electroretinography (ERG) will be used to assess the effect of RGS9-1/GBeta5-L over-expression on cone phototransduction...
  9. Axonal cytoskeletal changes in experimental glaucoma
    Brad Fortune; Fiscal Year: 2009
    ..structural testing for Aim 1, RGC function will also be assessed in both eyes using three proven forms of electroretinography (Aim 3)...
  10. CELLULAR MECHANISMS OF INHERITED RETINAL DEGENERATION
    Matthew LaVail; Fiscal Year: 2007
    ..These questions will be explored using intraocular injections of AAV vectors followed by functional (electroretinography and multifocal electroretinography) and structural (quantitative histology) analysis of the retina...
  11. CELLULAR MECHANISMS OF INHERITED RETINAL DEGENERATION
    Matthew LaVail; Fiscal Year: 2003
    ..therapeutic approaches more effective than single approaches; is functional rescue, which has been seen by electroretinography, a preservation of function or a recovery of function; what is the relationship between rod and cone ..
  12. Retinal degeneration caused by alterations in protein O-sulfation
    MUAYYAD AL UBAIDI; Fiscal Year: 2009
    ..these mice demonstrate a slow retinal degeneration characterized by a gradual loss of scotopic and photopic electroretinography (ERGs) that become very apparent at 4 months of age (-30% loss)...
  13. ELECTROPHYSIOLOGICAL STUDIES OF RETINAL DEGENERATIONS
    Eliot Berson; Fiscal Year: 1980
    ..Mice with known non-retinal X-linked mutations will be studied with electroretinography to seek models of human sex-linked retinal disease...
  14. Cone Opsin-Ligand Interactions and Photoreceptor Health
    Masahiro Kono; Fiscal Year: 2010
    ..can prevent the rapid degeneration of cone photoreceptor cells as judged by fluorescence microscopy and electroretinography. The ability to preserve the viability of cone photoreceptor celis in those afflicted with LCA will be a ..
  15. TX OF AUTOSOMAL DOMINANT EYE DISEASE USING CATALYTIC RNA
    Alfred Lewin; Fiscal Year: 2000
    ..Assays for activity include morphological analysis of retinal degeneration, quantitative mRNA studies, and electroretinography. We are testing the specific hypothesis that viral mediated retinal delivery of ribozymes to reduce ..
  16. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE ROWLAND; Fiscal Year: 2010
    ..restore function to and promoter survival of photoreceptors will be evaluated using visual behavior assays, electroretinography, fluorescent microscopic analyses of retinal whole mounts, and molecular and protein analyses techniques...
  17. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    Susan Semple Rowland; Fiscal Year: 2009
    ..restore function to and promoter survival of photoreceptors will be evaluated using visual behavior assays, electroretinography, fluorescent microscopic analyses of retinal whole mounts, and molecular and protein analyses techniques...
  18. Circadian Clock Regulation of the Mammalian Retina
    Charles Weitz; Fiscal Year: 2007
    ..genetic manipulation of the retina, 4) retinas can be conveniently collected for molecular studies, and 5) electroretinography provides a rapid and informative test of retinal function in living animals...
  19. Circadian Clock Regulation of the Mammalian Retina
    Charles J Weitz; Fiscal Year: 2010
    ..genetic manipulation of the retina, 4) retinas can be conveniently collected for molecular studies, and 5) electroretinography provides a rapid and informative test of retinal function in living animals...
  20. Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity
    Michael H Elliott; Fiscal Year: 2010
    ..Cav-1 null mice display reduced retinal function in Cav-1 null mice as indicated by electroretinography (ERG) that suggested at a photoreceptor defect...
  21. Circadian Clock Regulation of the Mammalian Retina
    Charles Weitz; Fiscal Year: 2009
    ..genetic manipulation of the retina, 4) retinas can be conveniently collected for molecular studies, and 5) electroretinography provides a rapid and informative test of retinal function in living animals...
  22. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2007
    ..Using fundal photography, electroretinography, and light and electron microscopy, we will test the hypothesis that mutations of VLGR1 lead to visual ..
  23. Visual Dysfunction in Retinal Degenerations
    Kenneth Alexander; Fiscal Year: 2005
    ..contrast coding through the use of innovative and sophisticated testing methods, including psychophysics, electroretinography (ERG), and the visual evoked potential (VEP), that are intended to target specific visual subsystems that ..
  24. PHOTORECEPTOR PROTECTION IN A MOUSE MODEL FOR USHER SYNDROME
    Wei Cao; Fiscal Year: 2002
    ..will be evaluated histologically by measuring the thickness of the outer nuclear layer and functionally by electroretinography. Proteomics and DNA-microarrays will be used to identify genes and proteins differentially expressed ..