electroretinography

Summary

Summary: Recording of electric potentials in the retina after stimulation by light.

Top Publications

  1. ncbi Rodent electroretinography: methods for extraction and interpretation of rod and cone responses
    A E Weymouth
    The University of Melbourne, Department of Optometry and Vision Sciences, Parkville, Victoria 3010, Australia
    Prog Retin Eye Res 27:1-44. 2008
  2. ncbi The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Ophthalmol 127:297-302. 2009
  3. pmc Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
    Deniz Dalkara
    Department of Chemical Engineering, The University of California at Berkeley, Berkeley, California 94720 3190, USA
    Mol Ther 17:2096-102. 2009
  4. pmc TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    INSERM, UMR_S968, F 75012, Paris, France
    Am J Hum Genet 85:720-9. 2009
  5. pmc TRPM1 mutations are associated with the complete form of congenital stationary night blindness
    Makoto Nakamura
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Vis 16:425-37. 2010
  6. ncbi ISCEV Standard for full-field clinical electroretinography (2008 update)
    M F Marmor
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA
    Doc Ophthalmol 118:69-77. 2009
  7. ncbi ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition)
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY, USA
    Doc Ophthalmol 124:1-13. 2012
  8. pmc Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information
    Kai Florian Storch
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 130:730-41. 2007
  9. ncbi Retinal degeneration mutants in the mouse
    B Chang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    Vision Res 42:517-25. 2002
  10. ncbi Effective gene therapy with nonintegrating lentiviral vectors
    Rafael J Yáñez-Muñoz
    Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nat Med 12:348-53. 2006

Detail Information

Publications409 found, 100 shown here

  1. ncbi Rodent electroretinography: methods for extraction and interpretation of rod and cone responses
    A E Weymouth
    The University of Melbourne, Department of Optometry and Vision Sciences, Parkville, Victoria 3010, Australia
    Prog Retin Eye Res 27:1-44. 2008
    ..The guidelines presented here are applicable to a wide range of investigations of retinal disease in rodent models...
  2. ncbi The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients
    Dikla Bandah
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Arch Ophthalmol 127:297-302. 2009
    ..To evaluate the involvement of NR2E3 in inherited retinal degenerative diseases in the Israeli and Palestinian populations and to study phenotypic variability in patients who are homozygous for the same mutation...
  3. pmc Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
    Deniz Dalkara
    Department of Chemical Engineering, The University of California at Berkeley, Berkeley, California 94720 3190, USA
    Mol Ther 17:2096-102. 2009
    ..These findings may help avoid limitations, risks, and damage associated with subretinal injections currently necessary for clinical gene therapy...
  4. pmc TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    INSERM, UMR_S968, F 75012, Paris, France
    Am J Hum Genet 85:720-9. 2009
    ..autosomal-recessive congenital stationary night blindness (CSNB) and can be assessed by standard full-field electroretinography (ERG), showing severely reduced rod b-wave amplitude and slightly altered cone responses...
  5. pmc TRPM1 mutations are associated with the complete form of congenital stationary night blindness
    Makoto Nakamura
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Vis 16:425-37. 2010
    ..To identify human transient receptor potential cation channel, subfamily M, member 1 (TRPM1) gene mutations in patients with congenital stationary night blindness (CSNB)...
  6. ncbi ISCEV Standard for full-field clinical electroretinography (2008 update)
    M F Marmor
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA
    Doc Ophthalmol 118:69-77. 2009
    ..Clinical Electrophysiology of Vision (ISCEV), presents an updated and revised ISCEV Standard for clinical electroretinography (ERG)...
  7. ncbi ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition)
    Donald C Hood
    Departments of Psychology and Ophthalmology, Columbia University, New York, NY, USA
    Doc Ophthalmol 124:1-13. 2012
    ..Standards for performance of the basic clinical mfERG test with a stimulus array of 61 or 103 hexagons, as well as for reporting the results, are specified...
  8. pmc Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information
    Kai Florian Storch
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell 130:730-41. 2007
    ..Our findings indicate that the intrinsic circadian clock of the retina regulates retinal visual processing in vivo...
  9. ncbi Retinal degeneration mutants in the mouse
    B Chang
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA
    Vision Res 42:517-25. 2002
    ..Through ophthalmoscopy, electroretinography and histology, we have discovered disorders affecting all aspects of the eye including the lid, cornea, ..
  10. ncbi Effective gene therapy with nonintegrating lentiviral vectors
    Rafael J Yáñez-Muñoz
    Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nat Med 12:348-53. 2006
    ..For therapeutic application to postmitotic tissues, this system substantially reduces the risk of insertional mutagenesis...
  11. pmc Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
    Marina S Gorbatyuk
    Department of Molecular Genetics, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 107:5961-6. 2010
    ..Thus, the preservation of photoreceptor function resulting from elevated levels of BiP is due to suppression of apoptosis rather than to a promotion of rhodopsin folding...
  12. pmc Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study
    Claudia Gargini
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, 56100 Pisa, Italy
    J Comp Neurol 500:222-38. 2007
    ..However, an overall slower decay of retinal structure and function predicts that rd10 mice might become excellent models for rescue approaches...
  13. pmc A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
    R S Stowers
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 152:1631-9. 1999
    ..We illustrate the utility of the method by applying it to lethal mutations in the synaptic transmission genes synaptotagmin and syntaxin...
  14. ncbi Evaluation of the rhodopsin knockout mouse as a model of pure cone function
    G B Jaissle
    Department II, University Eye Hospital, Tubingen, Germany
    Invest Ophthalmol Vis Sci 42:506-13. 2001
    ..To determine a time window in the rhodopsin knockout (Rho(-/-)) mouse during which retinal function is already sufficiently developed but cone degeneration is not yet substantial, thus representing an all-cone retina...
  15. ncbi Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage
    Balwantray C Chauhan
    Laboratory for Retina and Optic Nerve, Dalhousie University, Halifax, Nova Scotia, Canada
    Invest Ophthalmol Vis Sci 43:2969-76. 2002
    ..To characterize the effect of intraocular pressure (IOP) on optic disc topography, retinal function, and axonal survival in a model of IOP-induced optic nerve damage in rat...
  16. pmc Mutations in TRPM1 are a common cause of complete congenital stationary night blindness
    Maria M van Genderen
    Bartiméus, Institute for the Visually Impaired, 3702 AD Zeist, The Netherlands
    Am J Hum Genet 85:730-6. 2009
    ..Finally, we showed that detailed electroretinography is an effective way to discriminate among patients with mutations in either TRPM1 or GRM6, another ..
  17. pmc B-wave of the electroretinogram. A reflection of ON bipolar cell activity
    R A Stockton
    Department of Biophysical Sciences, State University of New York, School of Medicine, Buffalo 14214
    J Gen Physiol 93:101-22. 1989
    ....
  18. ncbi Retinopathy induced in mice by targeted disruption of the rhodopsin gene
    M M Humphries
    Wellcome Ocular Genetics Unit, Genetics Department, Trinity College, Dublin, Ireland
    Nat Genet 15:216-9. 1997
    ....
  19. pmc TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells
    Catherine W Morgans
    Department of Ophthalmology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:19174-8. 2009
    ..Identification of TRPM1 as a mGluR6-coupled cation channel reveals a key step in vision, expands the role of the TRP channel family in sensory perception, and presents insights into the evolution of vertebrate vision...
  20. ncbi A point mutation of the rhodopsin gene in one form of retinitis pigmentosa
    T P Dryja
    Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
    Nature 343:364-6. 1990
    ....
  21. ncbi The relationship between opsin overexpression and photoreceptor degeneration
    E Tan
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Invest Ophthalmol Vis Sci 42:589-600. 2001
    ..To characterize the process by which overexpression of normal opsin leads to photoreceptor degeneration...
  22. pmc Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    Gareth R Howell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Biol 179:1523-37. 2007
    ..protect against insults to axons, strongly protects against DBA/2J glaucoma and preserves RGC activity as measured by pattern electroretinography. These experiments provide strong evidence for a local insult to axons in the optic nerve.
  23. ncbi Post-receptoral contributions to the rat scotopic electroretinogram a-wave
    Trung M Dang
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Australia
    Doc Ophthalmol 122:149-56. 2011
    ..Second, OFF-pathway inhibition removed a corneal negativity that resides between the a-wave trough and the b-wave onset...
  24. ncbi Influence of recording electrode type and reference electrode position on the canine electroretinogram
    Alice E Mentzer
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Doc Ophthalmol 111:95-106. 2005
    b>Electroretinography is commonly used to assess the functional integrity of the retina...
  25. ncbi The contribution of cone responses to rat electroretinograms
    P J Nixon
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia
    Clin Experiment Ophthalmol 29:193-6. 2001
    ..The rat a-wave was found to be dominated by rod responses but cone responses contributed substantially (45%) to post-receptoral waveforms (b-wave) at higher light levels...
  26. pmc Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans
    Zheng Li
    University College London UCL Institute of Ophthalmology, London EC1V 9EL, UK
    Am J Hum Genet 85:711-9. 2009
    ..These findings suggest an important role of this specific cation channel for the normal function of ON bipolar cells in the human retina...
  27. pmc The scotopic threshold response of the dark-adapted electroretinogram of the mouse
    Shannon M Saszik
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    J Physiol 543:899-916. 2002
    ..These results support the use of the mouse ERG in studies of proximal retinal function...
  28. ncbi Late histological and functional changes in the P23H rat retina after photoreceptor loss
    Bogdan Kolomiets
    INSERM, UMR_S968, Institut de la Vision, F 75012, Paris
    Neurobiol Dis 38:47-58. 2010
    ....
  29. pmc Identification of a 2 Mb human ortholog of Drosophila eyes shut/spacemaker that is mutated in patients with retinitis pigmentosa
    Rob W J Collin
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    Am J Hum Genet 83:594-603. 2008
    ..With a size of 2 Mb, it is one of the largest human genes, and it is by far the largest retinal dystrophy gene. The discovery of EYS might shed light on a critical component of photoreceptor morphogenesis...
  30. pmc Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene
    B Chang
    The Jackson Laboratory, Bar Harbor, ME, USA
    Vision Res 47:624-33. 2007
    ..It may also provide a better model for experimental pharmaceutical-based therapy for RP because of its later onset and milder retinal degeneration than rd1 and nmf137...
  31. pmc Ganglion cell contributions to the rat full-field electroretinogram
    Bang V Bui
    Discoveries in Sight, Legacy Clinical Research and Technology Centre, 1225 NE 2nd Avenue, Portland, OR 97232, USA
    J Physiol 555:153-73. 2004
    ....
  32. ncbi A naturally occurring mouse model of X-linked congenital stationary night blindness
    M T Pardue
    Research Service, Hines VA Hospital, Illinois 60141, USA
    Invest Ophthalmol Vis Sci 39:2443-9. 1998
    ..To describe a naturally occurring X-linked recessive mutation, no b-wave (nob), that compromises visual transmission between photoreceptors and second-order neurons in mice...
  33. ncbi The gradient of retinal functional changes during acute intraocular pressure elevation
    Bang V Bui
    Discoveries in Sight, Devers Eye Institute, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 46:202-13. 2005
    ..To characterize retinal function during a period of acutely elevated intraocular pressure (IOP) across a wide range of IOPs, including those typically observed in animals with experimental glaucoma...
  34. pmc Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa
    Ji Jing Pang
    Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Mol Ther 19:234-42. 2011
    ..These results lay the groundwork for the development of PDEβ-RP gene therapy trial and suggest that tyrosine-capsid mutant AAV vectors may be effective for treating other rapidly degenerating models of retinal degeneration...
  35. ncbi The rate of functional recovery from acute IOP elevation
    Zheng He
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville 3010, Victoria, Australia
    Invest Ophthalmol Vis Sci 47:4872-80. 2006
    ..To evaluate the recovery of retinal function after acute IOP elevation...
  36. ncbi Oscillatory potential analysis and ERGs of normal and diabetic rats
    Heather A Hancock
    Departments of Medicine, University of Alabama, Birmingham, Alabama 35294, USA
    Invest Ophthalmol Vis Sci 45:1002-8. 2004
    ..To characterize and correlate the a- and b-wave properties of the ERGs of diabetic animals in parallel with the changes in oscillatory potentials...
  37. ncbi Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration
    Benedetto Falsini
    Dipartimento di Scienze Oftalmologiche e Otorinolaringologiche, Universita Cattolica del S Cuore, Rome, Italy
    Invest Ophthalmol Vis Sci 51:6118-24. 2010
    ..To evaluate the functional effect of short-term supplementation of saffron, a spice containing the antioxidant carotenoids crocin and crocetin, in early age-related macular degeneration (AMD)...
  38. ncbi SOD2 knockdown mouse model of early AMD
    Verline Justilien
    Department of Molecular Genetics, University of Florida, Gainesville, Florida, USA
    Invest Ophthalmol Vis Sci 48:4407-20. 2007
    ..To test the hypothesis that oxidative injury to the retinal pigment epithelium (RPE) may lead to retinal damage similar to that associated with the early stages of age-related macular degeneration (AMD)...
  39. ncbi Early retinal damage in experimental diabetes: electroretinographical and morphological observations
    Q Li
    Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Rappaport Institute, Haifa, Israel
    Exp Eye Res 74:615-25. 2002
    ..The observations indicate that the functional integrity of retinal cells is compromised already at short time intervals after onset of experimental diabetes in rats...
  40. ncbi Separation of receptor and lamina potentials in the electroretinogram of normal and mutant Drosophila
    M Heisenberg
    J Exp Biol 55:85-100. 1971
  41. pmc Therapeutic photobiomodulation for methanol-induced retinal toxicity
    J T Eells
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:3439-44. 2003
    ..They also suggest that photobiomodulation may enhance recovery from retinal injury and other ocular diseases in which mitochondrial dysfunction is postulated to play a role...
  42. ncbi Implantation of silicon chip microphotodiode arrays into the cat subretinal space
    A Y Chow
    Optobionics Corporation, Wheaton, IL 60187, USA
    IEEE Trans Neural Syst Rehabil Eng 9:86-95. 2001
    ..evaluated post-operatively over a 10 to 27 month period using indirect ophthalmoscopy, fundus photography, electroretinography, and histology...
  43. ncbi Human retinal disease from AIPL1 gene mutations: foveal cone loss with minimal macular photoreceptors and rod function remaining
    Samuel G Jacobson
    Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA
    Invest Ophthalmol Vis Sci 52:70-9. 2011
    ..To determine the human retinal phenotype caused by mutations in the gene encoding AIPL1 (Aryl hydrocarbon receptor-interacting protein-like 1) now that there are proof-of-concept results for gene therapy success in Aipl1-deficient mice...
  44. ncbi The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice
    Elena V Olshevskaya
    Hafter Research Laboratories, Pennsylvania College of Optometry, Elkins Park, Pennsylvania 19027, USA
    J Neurosci 24:6078-85. 2004
    ..These results provide the first direct evidence that a mutation linked to congenital blindness increases Ca2+ in the outer segment, which may trigger the apoptotic process...
  45. pmc Cone-rod dystrophy and a frameshift mutation in the PROM1 gene
    Eran Pras
    Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, 70300, Israel
    Mol Vis 15:1709-16. 2009
    ..To identify the genetic cause underlying autosomal recessive cone-rod dystrophy (CORD) and high myopia...
  46. ncbi Characterization of the rod photoresponse isolated from the dark-adapted primate ERG
    J A Jamison
    W.K. Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Vis Neurosci 18:445-55. 2001
    ....
  47. ncbi In vivo studies of signaling in rod pathways of the mouse using the electroretinogram
    J G Robson
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Vision Res 44:3253-68. 2004
    ..b) To estimate the level of this threshold and the amplitude of the continuous noise which it can serve to reduce. (c) To identify the location of the threshold mechanism in the rod to rod bipolar cell pathway...
  48. ncbi Alterations in serum fatty acid concentrations and desaturase activities in Bietti crystalline dystrophy unaffected by CYP4V2 genotypes
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Invest Ophthalmol Vis Sci 51:1092-7. 2010
    ..To evaluate the serum fatty acid changes in Chinese patients with Bietti crystalline dystrophy (BCD) in association with CYP4V2 mutation...
  49. ncbi Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging
    Baerbel Rohrer
    Department of Ophthalmology Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 44:310-5. 2003
    ..This project was designed to determine the amount of regenerable opsin in Rpe65-/- mice during development and aging, and to examine the function of this rhodopsin by electroretinography (ERG).
  50. ncbi Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor
    Kouki Fukuda
    Departments of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan
    Invest Ophthalmol Vis Sci 51:3629-38. 2010
    ..Dark-adapted full-field electroretinography (ERG) was also performed. RESULTS...
  51. ncbi Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: a review : Review of mfERG ring ratios in Plaquenil toxicity
    Jonathan S Lyons
    Georgetown University Washington National Eye Center, Washington, DC, USA
    Doc Ophthalmol 118:29-36. 2009
    ..It appears appropriate to recommend that mfERG testing be done on all patients on Plaquenil therapy...
  52. pmc Treatment of adult-onset acute macular retinoschisis in enhanced s-cone syndrome with oral acetazolamide
    Alessandro Iannaccone
    Retinal Degeneration and Ophthalmic Genetics Service, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Ophthalmol 147:307-312.e2. 2009
    ..To report on the efficacy of the oral carbonic anhydrase inhibitor (CAI) acetazolamide in treating macular retinoschisis (RS) in the rare vitreoretinal dystrophy best known as the enhanced S-cone syndrome (ESCS)...
  53. pmc Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration
    Tayebeh Rezaie
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Invest Ophthalmol Vis Sci 53:7847-54. 2012
    ..Here we investigated the antioxidant and neuroprotective activity of CA in retinal cell lines exposed to oxidative stress and in a rat model of light-induced retinal degeneration (LIRD)...
  54. ncbi The expanded clinical spectrum of deferoxamine retinopathy
    Robert Haimovici
    Department of Ophthalmology, Boston University School of Medicine, DOB 10 720 Harrison Avenue, Boston, MA 02118, USA
    Ophthalmology 109:164-71. 2002
    ..To describe early and unusual features in 16 patients with deferoxamine-induced retinal toxicity and to assess the role of diagnostic tests in the diagnosis and management of patients with the disorder...
  55. ncbi Morphological and functional retinal impairment in Alzheimer's disease patients
    V Parisi
    Clinica Oculistica Università di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 112:1860-7. 2001
    ....
  56. pmc Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans
    Huimin Wu
    University College London, Institute of Ophthalmology, London, United Kingdom
    Am J Hum Genet 79:574-9. 2006
    ....
  57. pmc The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses
    Bo Chang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Vis Neurosci 23:11-24. 2006
    ..Further, the nob2 mouse represents a model system in which to define the signals that guide synapse formation and/or maintenance in the OPL...
  58. ncbi Superoxide dismutase 1 protects retinal cells from oxidative damage
    Aling Dong
    Department of Ophthalmology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    J Cell Physiol 208:516-26. 2006
    ....
  59. ncbi Age-related retinal function changes in albino and pigmented rats
    Jason Charng
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
    Invest Ophthalmol Vis Sci 52:8891-9. 2011
    ..To investigate the effect of old age (3 vs. 18 months) on the retinal function of albino (Sprague-Dawley [SD]) and pigmented (Long-Evans [LE]) rats...
  60. pmc The Streptococcus pneumoniae capsule is required for full virulence in pneumococcal endophthalmitis
    Melissa E Sanders
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Invest Ophthalmol Vis Sci 52:865-72. 2011
    ..To determine whether Streptococcus pneumoniae capsule was necessary for pathogenesis of pneumococcal endophthalmitis...
  61. ncbi ISCEV standard for clinical pattern electroretinography (PERG): 2012 update
    Michael Bach
    University Eye Hospital, Killianstr 5, 79106, Freiburg, Germany
    Doc Ophthalmol 126:1-7. 2013
    ..The present revision tightens stimulus specifications, expands on steady-state PERG recording, addresses visual stimulus display distinctions (CRT vs. LCD), and provides a more explicit definition of response components...
  62. ncbi Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina
    Hiromi Ogishima
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
    Invest Ophthalmol Vis Sci 52:9710-20. 2011
    ..This study aimed to characterize the functional and morphologic changes in a murine model of ocular ischemic disease caused by vascular occlusion...
  63. ncbi Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels
    Tomoyoshi Fujita
    Department of Ophthalmology, Kagawa University, Kagawa, Japan
    Invest Ophthalmol Vis Sci 53:4099-110. 2012
    ..To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat...
  64. pmc Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1
    Sabine Hüttl
    Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, D 81377 Munchen, Germany
    J Neurosci 25:130-8. 2005
    ..Our results show that CNGB1 is a crucial determinant of native CNG channel targeting. As a result of the lack of rod CNG channels, CNGB1-/- mice develop a retinal degeneration that resembles human retinitis pigmentosa...
  65. pmc A recurrent mutation in GUCY2D associated with autosomal dominant cone dystrophy in a Chinese family
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, China
    Mol Vis 17:3271-8. 2011
    ..To identify the genetic locus and mutation responsible for autosomal dominant cone dystrophy (adCOD) in a large Chinese family and to describe the phenotypes of the patients...
  66. pmc Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness
    Isabelle Audo
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    Am J Hum Genet 90:321-30. 2012
    ..Interestingly, Gpr179 was highly concentrated in horizontal cells and Müller cell endfeet. The involvement of these cells in cCSNB and the specific function of GPR179 remain to be elucidated...
  67. pmc Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene
    Prateek K Buch
    University College London Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 6:e18089. 2011
    ..progression in this novel mouse model of cone dystrophy was determined by a variety of techniques including electroretinography (ERG), retinal histology, immunohistochemistry and measurement of cGMP levels...
  68. pmc Acute hypoglycemia decreases central retinal function in the human eye
    Mukhtar I Khan
    SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Vision Res 51:1623-6. 2011
    ..The association between low blood glucose levels and impaired central vision underscores the importance of avoiding when possible and promptly treating hypoglycemia, particularly in individuals with diabetes...
  69. ncbi Fundus albipunctatus associated with compound heterozygous mutations in RPE65
    Patrik Schatz
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Ophthalmology 118:888-94. 2011
    ..To describe a family with an 18-year-old woman with fundus albipunctatus and compound heterozygous mutations in RPE65 whose unaffected parents and 1 female sibling harbored single heterozygous RPE65 mutations...
  70. pmc Functional photoreceptor loss revealed with adaptive optics: an alternate cause of color blindness
    Joseph Carroll
    Center for Visual Science, University of Rochester, Rochester, NY 14627 0270, USA
    Proc Natl Acad Sci U S A 101:8461-6. 2004
    ..We confirm that remarkably, this loss of one-third of the cones does not impair any aspect of vision other than color...
  71. pmc Age-related retinopathy in NRF2-deficient mice
    Zhenyang Zhao
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 6:e19456. 2011
    ..The purposes of this study were to determine whether NRF2-deficient mice would develop AMD-like retinal pathology with aging and to explore the underlying mechanisms...
  72. ncbi A high association with cone dystrophy in Fundus albipunctatus caused by mutations of the RDH5 gene
    M Nakamura
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Invest Ophthalmol Vis Sci 41:3925-32. 2000
    ....
  73. pmc Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy
    David M Sherry
    Department of Cell Biology, University of Oklahoma Health Sciences Center, BMSB 781, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Eur J Neurosci 32:1461-72. 2010
    ....
  74. ncbi Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 119:819-26. 2012
    ..To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD)...
  75. pmc Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis
    Xia Li
    School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, People s Republic of China
    Invest Ophthalmol Vis Sci 52:7-15. 2011
    ..A prior study showed that AAV-mediated RPE65 expression can prevent early cone degeneration. The present study was conducted to test whether the remaining cones in older rd12 mice can be rescued...
  76. ncbi XIAP-mediated neuroprotection in retinal ischemia
    J Renwick
    University of Ottawa Eye Institute, Ottawa, Ontario, Canada
    Gene Ther 13:339-47. 2006
    ..Thus, XIAP-mediated gene therapy imparts both functional and structural protection to the retina after a transient ischemic episode...
  77. ncbi Pharmacological studies of the mouse cone electroretinogram
    Sumit Sharma
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44106, USA
    Vis Neurosci 22:631-6. 2005
    b>Electroretinography provides a useful noninvasive approach to evaluate cone pathway activity...
  78. ncbi Intraocular CNTF reduces vision in normal rats in a dose-dependent manner
    Trevor J McGill
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    Invest Ophthalmol Vis Sci 48:5756-66. 2007
    ..CNTF is a neuroprotective agent for retinal degenerations that can cause reduced electroretinogram (ERG) amplitudes. The goal of the present study was to determine the effects of intraocular delivery of CNTF on normal rat visual function...
  79. ncbi A novel Gly35Ser mutation in the RDH5 gene in a Japanese family with fundus albipunctatus associated with cone dystrophy
    Y Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Arch Ophthalmol 119:1059-63. 2001
    ..To assess the clinical and genetic characteristics of a Japanese family with fundus albipunctatus with progressive cone dystrophy associated with a mutation in the RDH5 gene...
  80. pmc Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration
    J Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
    Br J Ophthalmol 85:287-90. 2001
    ....
  81. ncbi Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy
    Yuko Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Am J Ophthalmol 139:894-9. 2005
    ..To describe the clinical and genetic characteristics of six Japanese families with Bietti's crystalline corneoretinal dystrophy (BCD)...
  82. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011
    ..To study cone photoreceptor structure and function in patients with inherited retinal degenerations treated with sustained-release ciliary neurotrophic factor (CNTF)...
  83. ncbi GABAC receptor-mediated inhibition in the retina
    Peter D Lukasiewicz
    Department of Ophthalmology, Washington University School of Medicine, Campus Box 8096, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Vision Res 44:3289-96. 2004
    ..These data suggest that GABAC receptors determine the time course and extent of inhibition at bipolar cell terminals that, in turn, modulates the magnitude of excitatory transmission from bipolar cells to ganglion cells...
  84. ncbi Assessing retinal function with the multifocal technique
    D C Hood
    Department of Psychology, Columbia University, 116th and Broadway, NY 10027 7004, New York, USA
    Prog Retin Eye Res 19:607-46. 2000
    ..It is speculated that a markedly diminished second-order kernel is diagnostic of outer plexiform layer damage, not inner plexiform layer damage as is commonly assumed...
  85. ncbi Phenotype of autosomal dominant cone-rod dystrophy due to the R838C mutation of the GUCY2D gene encoding retinal guanylate cyclase-1
    M Smith
    Department of Ophthalmology, Torbay Hospital, Torquay, Devon, UK
    Eye (Lond) 21:1220-5. 2007
    ..To describe the phenotype of members of a large Caucasian British family affected by autosomal dominant cone-rod dystrophy due to an R838C mutation in the guanylate cyclase 2D (GUCY2D) gene encoding retinal guanylate cyclase-1 (RETGC-1)...
  86. pmc Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina
    P Kofuji
    Departments of Neuroscience and Physiology, University of Minnesota, Minneapolis 55455, USA
    J Neurosci 20:5733-40. 2000
    ..The highly regulated localization and the functional properties of Kir4.1 in Müller cells suggest the involvement of this channel in the regulation of extracellular K(+) in the mouse retina...
  87. pmc Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model
    Tomas S Aleman
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 52:6898-910. 2011
    ..To investigate the human disease due to CRB1 mutations and compare results with the Crb1-mutant rd8 mouse...
  88. ncbi Congenital stationary night blindness in mice - a tale of two Cacna1f mutants
    N Lodha
    Department Medical Genetics, University of Calgary, Calgary, Alberta, Canada
    Adv Exp Med Biol 664:549-58. 2010
    ..We have characterized two putative murine CSNB2 models: an engineered null-mutant, with a stop codon (G305X); and a spontaneous mutant with an ETn insertion in intron 2 of Cacna1f (nob2)...
  89. ncbi Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration
    Qi Zhang
    A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hum Mol Genet 11:993-1003. 2002
    ..The cellular and molecular results in the two canine RPGR exon ORF15 mutations have implications for understanding the phenotypic variability found in human RP3 families that carry similar mutations...
  90. pmc Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram
    Deb Kumar Mojumder
    College of Optometry, University of Houston, 505 J Davis Armistead Bldg, 4901 Calhoun Road, Houston, TX 77204 2020, USA
    J Physiol 586:2551-80. 2008
    ..These findings indicate that activation of Na(v) channels in ON cone bipolar cells affects the b-wave of the rat ERG and must be considered when analysing results of ERG studies of retinal function...
  91. pmc Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa
    James W Kijas
    James A Baker Institute for Animal Health, Cornell University, 47 Hungerford Hill Road, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 99:6328-33. 2002
    ..The RHO mutant dog also becomes the large animal needed for preclinical trials of therapies for a major subset of human retinopathies...
  92. ncbi Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration
    D A Thompson
    Departments of Ophthalmology and Visual Sciences and Biological Chemistry, University of Michigan Medical School, Ann Arbor, USA
    Invest Ophthalmol Vis Sci 41:4293-9. 2000
    ..To characterize the spectrum of RPE65 mutations present in 453 patients with retinal dystrophy with an interest in understanding the range of functional deficits attributable to sequence variants in this gene...
  93. pmc In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function
    Stacey S Choi
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento 95817, USA
    Invest Ophthalmol Vis Sci 47:2080-92. 2006
    ..To relate in vivo microscopic retinal changes to visual function in patients who have various forms of retinal dystrophy...
  94. ncbi Early inner retinal dysfunction in streptozotocin-induced diabetic rats
    Kenichi Kohzaki
    Department of Ophthalmology, The Jikei University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:3595-604. 2008
    ..However, the effect that diabetes has on other ganglion cell-related responses is not known. This study was a systematic evaluation of streptozotocin (STZ) diabetes-related ERG changes in rats for the first 11 weeks after diabetogenesis...
  95. pmc Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina
    Gauri P Misra
    Department of Pharmaceutical Sciences, School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Philadelphia, PA 19107, USA
    Biomaterials 30:6541-7. 2009
    ..to the retina based on hematoxylin and eosin stain, immunostaining for microglial cell activation, and electroretinography. These subconjunctivally implantable hydrogels have potential for long-term periocular delivery of insulin ..
  96. ncbi Quantification of ischemic damage in the rat retina: a comparative study using evoked potentials, electroretinography, and histology
    Thomas Jehle
    University Eye Hospital Freiburg, Freiburg, Germany
    Invest Ophthalmol Vis Sci 49:1056-64. 2008
    ..The impact of ocular ischemia on luminance and frequency-modulated contrast vision was compared with the function of outer retinal cells and the number of intact retinal ganglion cells (RGCs)...
  97. ncbi Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal
    Baerbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charleston, 29425, USA
    Invest Ophthalmol Vis Sci 46:3876-82. 2005
    ..This study was designed to investigate the feasibility of restoring functional cones with exogenous 11-cis retinal...
  98. pmc Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene
    Jiangang Gao
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 99:5698-703. 2002
    ..The phenotype of Rp1 mutant mice resembles the human RP1 disease. Thus, these mice provide a useful model for studies of RP1 function, disease pathology, and therapeutic interventions...
  99. ncbi Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
    R M Petters
    Department of Animal Science, North Carolina State University, Raleigh, USA
    Nat Biotechnol 15:965-70. 1997
    ..Given the strong similarities in phenotype to that of RP patients, these transgenic pigs will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials...
  100. pmc The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
    Wolfgang Baehr
    Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 282:8837-47. 2007
    ..We interpret these results to demonstrate an intrinsic requirement of GCs for stability and/or transport of a set of membrane-associated phototransduction proteins...
  101. pmc Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse
    Shannon E Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e11306. 2010
    ..The purpose of this study was to test whether delivery of functional GC1 to cone cells of the postnatal GC1KO mouse could restore function to these cells...

Research Grants63

  1. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..Retinal function will be determined by electroretinography. We currently have large colonies of both the tubby and the Trx-tubby mice and will be able to complete the ..
  2. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..Third, we will turn to functional assays using computerized pupillometry and electroretinography (ERG) to determine the ability of transplanted MSCs and locally released neurotrophic factors to restore ..
  3. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ..Fundoscopy, electroretinography and optical coherence tomography will be used for longitudinal studies on the same animal to evaluate ..
  4. Downregulation of Rod Metabolism in Retinopathy of Prematurity
    JAMES DANIEL AKULA; Fiscal Year: 2010
    ..animals), function of the neural retina (both photoreceptor and postreceptor) is objectively assessed by electroretinography (ERG)...
  5. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Targ
    Yan Zhang; Fiscal Year: 2013
    ..including high frequency A-scan ultrasonography, spectral domain optical coherence tomography (SD-OCT) and electroretinography (ERG)...
  6. Unfolded Protein Response as a Therapeutic Target for ADRP Animal Models
    Marina Gorbatyuk; Fiscal Year: 2013
    ..We will monitor survival of photoreceptors using electroretinography and morphometry and will measure the activation of the ER stress and apoptosis using specific antibodies ..
  7. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..Laura Frishman (Univ. Houston), an expert in the electroretinography, who will assist in refining protocols for isolating the inner retinal pathways of the guinea pig, 2) Dr...
  8. Imaging retinal astrocytes, ganglion cells and axonal transport in vivo
    Brad Fortune; Fiscal Year: 2012
    ..of in vivo astrocyte markers and axonal transport tracers using sensitive measures of retinal function (electroretinography, ERG) and retinal structure (spectral domain optical coherence tomography, SDOCT), so as to assess ..
  9. STUDIES IN GLAUCOMATOUS OPTIC NERVE DAMAGE
    John C Morrison; Fiscal Year: 2013
    ..assessment of retinal ganglion cell/inner retina injury with the scotopic threshold response (STR) by electroretinography. We will then (b) use a microarray cluster analysis to determine the chronological cascade of gene ..
  10. Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity
    Michael H Elliott; Fiscal Year: 2013
    ..Cav-1 null mice display reduced retinal function in Cav-1 null mice as indicated by electroretinography (ERG) that suggested at a photoreceptor defect...
  11. Investigation of autoimmune anti-retinal antibodies in diabetes
    John R Heckenlively; Fiscal Year: 2013
    ..undergo clinical testing-specifically, dark adaptometry to measure final rod thresholds and standardized electroretinography to measure cone and rod function...
  12. Investigating the role of ribeye in retinal ribbon function
    DAVID PAUL ZENISEK; Fiscal Year: 2013
    ..the effects of over expression of wild-type and mutant ribeye on retinal responses to light using electroretinography. In preliminary experiments, we have identified transgenic lines that exhibit altered ERG b-wave responses...
  13. The roles of Gbeta5 and R7 RGS protein in vision
    Ching Kang Jason Chen; Fiscal Year: 2013
    ..at outer plexiform layer (OPL) with unincorporated depolarizing bipolar cells (DBC) dendrites~ 4) lack of electroretinography (ERG) b-waves~ 5) reduction of starburst amacrine cell (SAC) dendritic field, 6) rhythmic oscillation SAC ..
  14. High-resolution imaging of the normal and diseased retina
    Jason Porter; Fiscal Year: 2013
    ..These data will be combined with changes in visual function (standard automated perimetry and electroretinography) and retinal nerve fiber layer (RNFL) thickness (using optical coherence tomography) at corresponding time-..
  15. Rescue of GUCY1*B Phenotype Using Somatic Gene Therapy
    SUSAN LYNN SEMPLE-ROWLAND; Fiscal Year: 2012
    ..restore function to and promoter survival of photoreceptors will be evaluated using visual behavior assays, electroretinography, fluorescent microscopic analyses of retinal whole mounts, and molecular and protein analyses techniques...
  16. Cone Opsin-Ligand Interactions and Photoreceptor Health
    Masahiro Kono; Fiscal Year: 2013
    ..Fluorescence microscopy, electroretinography, mass spectrometry, and biochemicial methods will be used to assess the effects of test compounds on cone ..
  17. Cellular Mechanisms of Retinopathy: Role of Arginase
    Ruth B Caldwell; Fiscal Year: 2013
    ..use molecular approaches to manipulate A1 and A2 expression in combination with real-time vascular imaging, electroretinography and morphometric analyses of neuronal and vascular injury...
  18. Circadian Clock Regulation of the Mammalian Retina
    Charles J Weitz; Fiscal Year: 2010
    ..genetic manipulation of the retina, 4) retinas can be conveniently collected for molecular studies, and 5) electroretinography provides a rapid and informative test of retinal function in living animals...
  19. Mechanisms limiting visual performance in retinal degenerations
    JAMES JASON MCANANY; Fiscal Year: 2010
    ..During the mentored phase, the applicant will master clinical vision testing methods, such as electroretinography and retinal imaging, while conducting mentored research...
  20. DEVELOPING A MOUSE RETINAL MODEL OF NEURODEGENERATIVE DISEASE
    Marc I Diamond; Fiscal Year: 2012
    ..demonstrated that this is associated with progressive loss of function in tests of retinal physiology (electroretinography)...
  21. Targeting Muller Cells to Treat Optic Nerve Injury
    Sherry Ball; Fiscal Year: 2009
    ..Methodology: Electroretinography (ERG) will be used to noninvasively follow retinal function and injury responses in the retina using no b-..
  22. Axonal cytoskeletal changes in experimental glaucoma
    Brad Fortune; Fiscal Year: 2012
    ..During each week of in vivo structural testing for Aim 1, RGC function will also be assessed in both eyes using three proven forms of electroretinography (Aim 3).
  23. Phase 1/2 Trial of rAAV2-CB-hRPE65 (BB-IND 13848, 11 Sep 2009) for Leber Congenit
    Jeffrey D Chulay; Fiscal Year: 2013
    ..Efficacy will be measured by evaluation of visual fields, visual acuity and electroretinography.
  24. Mouse Model of DBC Dysfunction
    Neal S Peachey; Fiscal Year: 2012
    ..In Aim 2, we will define the nob5 phenotype with respect to retinal function, using electroretinography and whole-cell patch clamp recordings from rod and cone DBCs and cone hyperpolarizing bipolar cells, and ..
  25. Retinal degeneration diseases and the visual retinoid cycle
    Akiko Maeda; Fiscal Year: 2012
    ..drugs by biochemical methods such as HPLC (high pressure liquid chromatography) and mass-spectrometry, and electroretinography, and histological/histocytochemical assessment...
  26. P30 - CORE GRANT FOR VISION RESEARCH
    Samuel M Wu; Fiscal Year: 2013
    ..for biochemical analysis of proteins and small molecules, and functional analysis of vision using electroretinography (ERG) and opto-metor reflex assays (6) To foster collaborations among vision researcher groups at Baylor ..
  27. Photophobia during migraine: sensory, autonomic and emotional responses to light
    Rami Burstein; Fiscal Year: 2013
    ..Data analysis and interpretation will include strength of electroretinography and visual evoked potential signals (waveforms) as well as documentation of sensory, affective and ..
  28. Airborne Nanoparticles for Therapeutic Applications
    Amir Naqwi; Fiscal Year: 2009
    ..Safety of the treatment will be established on the basis of retinal imaging, electroretinography and histopathology...
  29. PHYSICAL MAP OF RP2 AND RP3 LOCI ON HUMAN X-CHROMOSOME
    BRATIN SAHA; Fiscal Year: 1990
    ..The RFLP probes available today are not suitable for this purpose. Funduscopic examination and electroretinography (ERG) can detect only a portion of carriers only when tested in the later stage of life...
  30. MARROW TRANSPLANT THERAPY FOR MUCOPOLYSACCHARIDOSIS
    MARY THRALL; Fiscal Year: 1992
    ..at 6 months then yearly post-BMT by radiography, photography, computed tomography, slit lamp biomicroscopy, electroretinography, and light and electron microscopy of liver, brain, cartilage, and skin biopsies and necropsy tissues...
  31. RESCUE OF RETINAL DEGENERATION BY GENE THERAPY
    MICHAEL SUBER; Fiscal Year: 1999
    ..b>Electroretinography (ERG) will be performed on the mice to appraise the efficacy of rescue...
  32. ANTISENSE INHIBITION OF RETINAL GLUTAMATE METABOLISM
    John Danias; Fiscal Year: 2003
    ..GS and GLAST, intra-vitreal glutamate concentrations, and visual function by electroretinography. Aim 2 tests whether glutamate antagonists and anti-apoptosis agents can reverse the effects of a deranged ..
  33. VISUAL TESTING OF INFANTS REARED IN NEONATAL ICUS
    Joelle Mast; Fiscal Year: 1992
    ..VEPs), forced-choice preferential looking (FPL), and electroretinography (ERG) to the human infant...
  34. GYRATE ATROPHY OF THE CHOROID AND RETINA
    RICHARD WELEBER; Fiscal Year: 1980
    ..Two of the three in vivo B6 responders have shown improvement of electroretinography when treated and decreased electroretinographic responses when supplemented B6 was discontinued...
  35. SUBRETINAL TRANSPLANTATION OF ISLETS OF LANGERHANS
    Dennis Rickman; Fiscal Year: 2000
    ..Any related alterations in retinal function and structure will be determined using fundus photography, fluorescein angiography, electroretinography and histological and electron microscopic techniques.
  36. Multi-Electrode Electroretinography: Toward Single-Flash Mapping of Retinal Func
    John Hetling; Fiscal Year: 2009
    ..A new method for mapping spatial differences in retinal activity, using a full-field stimulus and an array of electrodes on the cornea, is proposed here. This method has several advantages over existing methods. ..
  37. Elovl4 in Retinal Physiology and Pathophysiology
    Wojciech Kedzierski; Fiscal Year: 2009
    ..Their retinas will be subject to structural, functional and biochemical studies using microscopy, electroretinography, as well as lipid and protein analysis...
  38. Histopathology and Electroretinography Services
    Richard Smith; Fiscal Year: 2007
    ..It is anticipated that both the histology and ERG modules will help attract new scientists to eye research. [unreadable] [unreadable]..
  39. Expression and Regulation of Retinal Angiotensin II
    Preenie Senanayake; Fiscal Year: 2005
    ..b>Electroretinography will be used to evaluate retinal function, which will be correlated with blood pressure measured by tail ..
  40. TOPOGRAPHICAL ANALYSIS OF RHODOPSIN
    MUAYYAD AL UBAIDI; Fiscal Year: 1999
    ..b>Electroretinography and suction pipette single cell recording will be used to determine the effects of transgene expression on ..
  41. VITREOPERFUSION--A NEW APPROACH TO OCULAR ISCHEMIA
    NORMAN BLAIR; Fiscal Year: 1992
    ..The methods of assessment include light and electron microscopy, electroretinography, and energy metabolism measurements...
  42. ELECTRORETINOGRAPHY IN AGE-RELATED MACULAR DEVELOPMENT
    David Birch; Fiscal Year: 1991
    ..It is anticipated that this approach will be of value not only in the assessment of treatment efficacy within the context of the FPS trial, but also will be of value in future treatment trials in patients with AMD...
  43. WITHIN-SPECIES VARIATIONS IN VISUAL CAPACITY
    GERALD JACOBS; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  44. Visual Dysfunction in Retinal Degenerations
    Kenneth R Alexander; Fiscal Year: 2010
    ....
  45. PHENOTYPING THE MOUSE VISUAL SYSTEM
    EDWARD PUGH; Fiscal Year: 2002
    ..Illumination rearing conditions have profound effects on murine retinal health and function in electroretinography. Therefore, pupillometry and retinal histology will be used to quantify the effects of rearing illumination ..
  46. A KINETIC STUDY OF INFLAMMATION-INDUCED HYPORETINEMIA
    Francisco Rosales; Fiscal Year: 2005
    ..Retinal function will be examined by means of electroretinography during the first and second weeks of experimentation...
  47. Model for dominant Stargardt-like macular dystrophy
    Wojciech Kedzierski; Fiscal Year: 2006
    ..by structural, functional, and biochemical studies of the retina, using microscopy, immunocytochemistry, electroretinography, as well as lipid and protein analysis...
  48. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  49. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
  50. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  51. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
    ..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
  52. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
    ....
  53. RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTS
    David Birch; Fiscal Year: 2005
    ..In the mouse models, cone measures will necessarily focus on the b-wave, using monochromatic stimuli, long-duration flashes, and flicker to optimize isolation of cone from rod responses. ..
  54. A System for Study of Pediatric Visual Pathways
    Anne Fulton; Fiscal Year: 2004
    ..With these studies as a whole, we expect to obtain new knowledge about the processes that govern vision and its development in these pediatric disorders. ..
  55. Retcam 120 Wide Field Digital Imaging System
    Anne Fulton; Fiscal Year: 2002
    ..The minor users will take advantage of the wide field images as well as the highly magnified views of the macula and optic nerve head (optic disc), including the fluorescein capability. ..
  56. RESPIRATORY VIRUS ION CHANNELS
    LAWRENCE PINTO; Fiscal Year: 2007
    ..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]..
  57. Studies on Influenza B Virus BM2 Protein Ion Channel
    LAWRENCE PINTO; Fiscal Year: 2009
    ....
  58. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..
  59. High Throughput Assays for Ion Channel Activities of Influenza A & B Viruses
    LAWRENCE PINTO; Fiscal Year: 2006
    ..These assays will make it possible to perform efficient searches for antiviral drugs against the M2 ion channels. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Reading Enhancement for Patients with Visual Field Loss
    MICHAEL SANDBERG; Fiscal Year: 2004
    ....
  61. Melanopsin-based form vision in photoreceptor disease
    MICHAEL SANDBERG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  62. The Mouse dc-Electroretinogram
    Neal Peachey; Fiscal Year: 2005
    ..abstract_text> ..
  63. Nanoparticle & AAV Approaches to Rapid Onset, Stable Retinal Gene Therapy
    Jijing Pang; Fiscal Year: 2008
    ..Our ultimate goal is to establish a retinal gene delivery system that is fast, of long duration and can accommodate large therapeutic cDNAs. [unreadable] [unreadable] [unreadable]..