ophthalmological diagnostic techniques

..To determine the sensitivity and specificity of measurements of the retinal nerve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual field (VF) defects...

..To compare the ability of optical coherence tomography retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to differentiate between healthy eyes and eyes with glaucomatous visual field loss...

..To study the results of an ocular response analyzer (ORA) to determine the biomechanical properties of the cornea and their relationship to intraocular pressure (IOP)...

..These disk size- dependent variations may influence the susceptibility to glaucoma or the likelihood of glaucoma diagnosis. This manuscript reviews the published evidence relating to disk size and glaucoma...

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..To compare hysteresis, a novel measure of ocular rigidity (viscoelasticity) in normal and keratoconic eyes...

..Objective PCO assessment by automated image-analysis systems is, therefore, a valuable and clinically relevant method for clinical studies of the development and prevention of PCO...

..To compare optic disk and retinal nerve fiber layer (RNFL) imaging methods to discriminate eyes with early glaucoma from normal eyes...

..To assess repeatability, reproducibility, and agreement of rotating Scheimpflug camera (Pentacam Oculus, Wetzlar, Germany) and ultrasound pachymetry in measuring central thickness of keratoconic corneas...

..CONCLUSIONS: With the commercially available GDx VCC, a learning effect was not found for 3 novice operators. In addition, RNFL measurements seem highly reproducible across operators...

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..To evaluate quantitatively the intraobserver reproducibility of measurements of the retinal nerve fiber layer (RNFL) in healthy subjects and an ocular hypertensive population using two nerve fiber analyzers...

..To compare intraocular pressure (IOP) obtained from the ocular response analyzer (ORA) and Goldmann applanation tonometer (GAT) on a group of normal Chinese...

..To study the agreement between ultrasound (US) and Orbscan II (Bausch & Lomb) measurements with different ranges of central thickness in normal corneas...

..To assess the degree of agreement of anterior chamber depth (ACD) measurements by 2 optical devices (Orbscan II and IOLMaster) and compare them with contact ultrasound A-scan...

..To compare corneal pachymetry assessment using 4 measurement methods in eyes after laser in situ keratomileusis (LASIK) for myopia...

..To assess the agreement of central and paracentral corneal thickness measurements between ultrasound pachymetry (USP), Orbscan II, and Visante anterior segment optical coherence tomography (ASOCT)...

..To assess the effect of atypical pattern of retardation (APR) on retinal nerve fibre layer (RNFL) measurements made by scanning laser polarimetry (SLP) with variable corneal compensation (GDx-VCC) in glaucomatous eyes...

..001). CONCLUSIONS: There is a strong topographic correlation between characteristics of localized RNFL defects as determined by OCT and red-free photography...

..To compare central corneal thickness measurements and their reproducibility when taken by a rotating Scheimpflug camera, ultrasonic pachymetry, and scanning-slit corneal topography/pachymetry...

..Depth measurements were made from the corneal epithelium to the anterior lens surface. The values obtained were compared using Bland-Altman analysis...

..To examine the repeatability and effect of an enhancement module on the severity of atypical birefringence patterns (ABP) using scanning laser polarimetery (SLP) with variable corneal compensation (VCC)...

..The HOA RMS data were closer between LADARWave and WaveScan, and HOA RMS by Zywave was generally higher than the other 2 devices. The 3 devices had comparable measurement variation...

..To investigate the potential advantages of an enhanced corneal compensation algorithm (ECC) compared with variable corneal compensation (VCC), in scanning laser polarimetry...

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..Reference height difference and image quality were the factors that most influenced RA measurement variability. Image analysis strategies that address these factors may reduce test-retest variability...

..To compare the accuracy and repeatability of the OCULUS Pentacam (a new Scheimpflug-based imaging system) with ultrasound pachymetry in the measurement of central corneal thickness (CCT)...

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..To evaluate the ability of scanning laser polarimetry parameters and a novel deviation map algorithm to discriminate between healthy and early glaucomatous eyes with localized visual field (VF) defects confined to one hemifield...

..CONCLUSIONS: This study provides reference values for higher order aberrations in normal refractive surgery candidates. Wavefront analysis also proved to be a valuable tool for objectively measuring preoperative refractive error...

..Dublin, CA) and GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA)...

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..Detection of localized changes in macular thickness is limited by measurement overlap among normal and glaucomatous eyes...

..To assess reproducibility of central corneal thickness (CCT) measurement by means of ultrasonic pachymetry...

..Ray tracing aberrometry developed by the Institute of Biomedical Engineering (Kiev) and first tested at the Vardinoyannion Eye Institute of Crete is a promising technique for eye refraction aberration and refraction mapping...

..Whether and how macular diseases affect this method remain to be investigated...

..To compare central corneal thickness (CCT) measurements obtained with 3 ultrasound pachymeters and with partial coherence interferometry (PCI) and evaluate the effect of repeated contact by a pachymetry probe on corneal thickness...

..Central corneal thickness (CCT) of 74 eyes from 39 normal Hong Kong Chinese subjects with ages ranging from 39 to 86 years were studied...

..This study was devised to investigate whether ORA-derived IOP and corneal biomechanical variables might be useful in discriminating between subjects with and without primary open-angle glaucoma (GLC)...

..This study further demonstrates that the OCT measurements show a high degree of repeatability and reproducibility. Thus, OCT is emerging as a promising tool for evaluation of CCT in the clinical setting...

..Considering the basic and simple measurement principle of these instruments, they appear to provide the correct result. The A-scan equipment used in this study is unsuitable for determination of ACD in eyes with PMMA IOLs...

..The variation in ACDR and RCDR measurements between the two systems may be too large for interchangeable use in a clinical setting...

..A combination of the imaging methods significantly improves this capability...

..To investigate the relationship between optic disc changes measured with scanning laser tomography and those measured with conventional perimetry and optic disc photography...

..Nevertheless, there are excellent prospects for using longitudinal assessment of the RNFL in clinical trials of glaucoma neuroprotection...

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..To obtain a diagnosis of tuberculosis in patients with a specific subset of uveitis, serpiginous-like choroiditis. This subset has been suspicious for tuberculous etiology in single case reports and old textbooks...

..To examine the relationship between ametropia and optical aberrations in a population of 200 normal human eyes with refractive errors spanning the range from +5.00 to -10.00 D...

..This article reports a patient with decreased vision following branch retinal vein occlusion in whom the Retinal Thickness Analyzer was used to establish the diagnosis of a macular lamellar hole that was not apparent clinically...

..66 vs 0.80), and superior average (0.68 vs 0.83). CONCLUSION: Variable corneal compensation to correct for subject-specific CPM and CPA can improve the ability of SLP to discriminate between healthy and glaucomatous eyes...

..Under these conditions, aberrometry measurements should be repeated several times and outliers should be excluded in calculating the means...

..The noncontact optical method, which is essentially operator independent, gave significantly more reliable biometry before cataract surgery, especially in the case of less experienced operators...

..317, 0.273, and 0.176, respectively; all P<.002). CONCLUSION: Wavefront aberrations varied widely among subjects and increased slightly with age. A moderate to high degree of mirror symmetry existed between right and left eyes...

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..The GCP methods determined progression earliest; however, they were generally not as specific. Methods based on PLRA were specific but times to confirmed progression were the longest...

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..With FC, however, the GDx retardation images did not correlate well with red-free fundus photography. CONCLUSIONS: An individualized anterior segment compensation in the GDx improves the visualization of localized glaucomatous loss...

..In this sample, the LDFs and MRA generally did not discriminate between glaucoma patients and controls as well as reported in the original respective studies that described the methods...

..This study attempted to determine whether the indentation of the cornea with an ultrasonic probe affects the corneal-thickness measurement...

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..To compare central corneal thickness measurements obtained with Orbscan II using the acoustic equivalent correction factor (CF) and Pentacam in eyes screened for refractive surgery...

..The difference between all groups was statistically significant (P < 0.0001). CONCLUSIONS: Orbscan pachymetric values may be underestimated and less accurate after LASIK and PRK...

..To assess Stratus optical coherence tomography (OCT) original parameters for identifying glaucomatous damage and to evaluate differences among glaucomatous, ocular hypertensive, and normal eyes...

..To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols...

..This study was designed to determine the specificity and sensitivity of the Heidelberg Retina Tomograph I (HRT) using the Moorfields Regression Analysis (MRA) in differentiating healthy from glaucomatous eyes...

..To compare three types of digital images for assessment of retinal nerve fiber layer (RNFL) defects: red-free RNFL images, color nonmydriatic images, and digitally converted nonmydriatic red-free fundus images...

..To compare the effectiveness of Humphrey Matrix perimetry, GDx VCC, Stratus OCT, and retinal nerve fiber layer (RNFL) photography using the Heidelberg Retina Angiograph 1 (HRA1) for early glaucoma detection...

..Dublin, CA) in a Taiwan Chinese population...

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..To compare retinal nerve fiber layer (RNFL) and optic disc topographic imaging for detection of optic nerve damage in patients suspected of having glaucoma...

..To assess the advantage in glaucoma screening of the use of scanning laser polarimetry with customized cornea compensation (GDx-VCC) combined with Matrix Frequency Doubling Technology (M-FDT) testing...

..To compare the effect of disc size and disease severity on the Heidelberg Retina Tomograph (HRT) Glaucoma Probability Score (GPS) and the Moorfields Regression Analysis (MRA) for discriminating between glaucomatous and healthy eyes...

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..2) To compare the performance of the shape-based metrics to that of the standard OCT output measures (Inferior Average and Average Thickness)...

..Dublin, CA) assessed by receiver operating characteristic (ROC) curves for discriminating between glaucoma and healthy eyes...

..7351) (P = 0.0128). CONCLUSION: The PPA measurement obtained by HRT can be a useful additional tool to differentiate NTG from GLD after the first screening by disk photograph in a routine health checkup...

..CONCLUSIONS: A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods...

..98). CONCLUSIONS: ABP images exist in a subset of normal and glaucomatous eyes, are associated with older patient age, and produce an artifactual increase in RNFL thickness using GDx-VCC. The SVM score is highly predictive of ABP images...

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..007, for both) CONCLUSIONS: OCT ONH and NFL parameters provided similar discrimination capabilities between healthy eyes and those of glaucoma patients and superior discrimination capabilities when compared with macular parameters...

..Some measurements of the macular thickness in specific areas may differ systematically for different wavelengths, but in most cases the difference is small...

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..To evaluate a new Fourier-based analysis method for diagnosing glaucoma using retinal nerve fiber layer (RNFL) thickness estimates obtained from the optical coherence tomograph (OCT) (OCT 2000) and the scanning laser polarimeter (GDx)...

..The authors evaluated the sensitivity and specificity of the Number and examined whether expert clinical judgment of GDx printouts leads to a better separation...

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..The most sensitive OCT and FDT parameters tended to be more sensitive than the most sensitive SWAP and SLP parameters at the specificities investigated, regardless of diagnostic criteria...

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..To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography...

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..To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes...

..CONCLUSIONS: This case demonstrates that digital imaging of the peripapillary RNFL is capable of documentation and measurement of progressive glaucomatous RNFL atrophy...

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..These same techniques can enable the ophthalmologist to monitor the health of these cells and, thus the effectiveness of alternative treatments. ..

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..Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON). ..

..monkeys in which INL activity is pharmacologically dissected, b. normal human subjects, c. patients with disease of the INL, and d. mathematical work. ..

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..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..

..Once refined, the technique will serve as a valuable tool for investigating disease-related oxygen dynamics, and thereby, can significantly impact the understanding of the pathophysiology, diagnosis and treatment of retinal diseases. ..

..Once refined, the technique will serve as a valuable tool for investigating disease-related oxygen dynamics, and thereby, can significantly impact the understanding of the pathophysiology, diagnosis and treatment of retinal diseases. ..

..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..

..Columbia University has a strong existing framework in medical information systems, telemedicine, and public health, which will be leveraged to complete this training and research program successfully. ..

..We propose as part of aim 3 to improve our understanding of these relationships as well as to improve our analysis of visual field data. ..

..This could be especially valuable in assessing retinal function of patients with heterogeneous damage as in retinitis pigmentosa, diabetic retinopathy, and glaucoma. ..

..Finally, we intend to obtain a better understanding of the relative involvement of the rod and different cone mechanisms in retinitis pigmentosa and in progressive cone dystrophy...

..Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors...

..The data will be analyzed within the context of recent models of cone systems, models based on recent physiology...

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..The work in this proposal will serve as the foundation for translation of this same approach to the future study of other retinal degenerations, which will accelerate progress for the effective implementation of novel therapies. ..

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..The work in this proposal will serve as the foundation for translation of this same approach to the future study of other retinal degenerations, which will accelerate progress for the effective implementation of novel therapies. ..

..This proposal addresses the need for research to assess tailored print communications to increase eye examination behavior in a minority population at increased risk for glaucoma. ..

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..The work in this proposal will serve as the foundation for translation of this same approach to the future study of other retinal degenerations, which will accelerate progress for the effective implementation of novel therapies. ..

..It will allow obtaining medical images with exquisite resolution, increased depth of field and a greater depth of penetration, and lead to new capabilities for improved diagnostic imaging and disease management. ..

..In addition, the knowledge gained through this investigation could also help in the identification of patients at risk of developing choroidal neovascularization, thus enabling earlier treatment. ..

..This project will then lead to a larger, more comprehensive survey of the prevalence and causes of visual impairment in AI/AN. ..

..This assessment of the RTA and NFA will help to establish their utility as outcome measures for clinical management of glaucoma, epidemiological research, and clinical trials. ..

..In addition, the knowledge gained through this investigation could also help in the identification of patients at risk of developing choroidal neovascularization, thus enabling earlier treatment. ..

..The results of the study may allow physicians to reduce the morbidity of glaucoma surgery by altering their indications for surgery, surgical technique, and postoperative follow-up. ..

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