electrocardiography

Summary

Summary: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.

Top Publications

  1. ncbi The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III Registry ECG Ancillary Study. Thrombolysis in Myocardial Ischemia
    C P Cannon
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 30:133-40. 1997
  2. ncbi Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging
    Toon A B van Veen
    Heart Lung Center, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 112:1927-35. 2005
  3. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Aarhus C, Denmark
    Eur Heart J 28:2525-38. 2007
  4. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Gade 2, DK 8000 Aarhus C, Denmark
    J Am Coll Cardiol 50:2173-95. 2007
  5. ncbi Heart rate variability: origins, methods, and interpretive caveats
    G G Berntson
    Department of Psychology, Ohio State University, Columbus 43210, USA
    Psychophysiology 34:623-48. 1997
  6. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
  7. ncbi Drug-induced prolongation of the QT interval
    Dan M Roden
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 350:1013-22. 2004
  8. ncbi ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Com
    Douglas P Zipes
    J Am Coll Cardiol 48:e247-346. 2006
  9. ncbi Estimated radiation dose associated with cardiac CT angiography
    Jorg Hausleiter
    Department of Cardiology, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 München, Germany
    JAMA 301:500-7. 2009
  10. ncbi Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients
    Maria Teresa La Rovere
    Divisione di Cardiologia e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Pavia, Italy
    Circulation 107:565-70. 2003

Detail Information

Publications358 found, 100 shown here

  1. ncbi The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III Registry ECG Ancillary Study. Thrombolysis in Myocardial Ischemia
    C P Cannon
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 30:133-40. 1997
    ..We sought to determine the prognostic value of the admission electrocardiogram (ECG) in patients with unstable angina and non-Q wave myocardial infarction (MI)...
  2. ncbi Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging
    Toon A B van Veen
    Heart Lung Center, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 112:1927-35. 2005
    ..The SCN5A sodium channel is a major determinant for cardiac impulse propagation. We used epicardial mapping of the atria, ventricles, and septae to investigate conduction velocity (CV) in Scn5a heterozygous young and old mice...
  3. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Aarhus C, Denmark
    Eur Heart J 28:2525-38. 2007
  4. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Gade 2, DK 8000 Aarhus C, Denmark
    J Am Coll Cardiol 50:2173-95. 2007
  5. ncbi Heart rate variability: origins, methods, and interpretive caveats
    G G Berntson
    Department of Psychology, Ohio State University, Columbus 43210, USA
    Psychophysiology 34:623-48. 1997
    ..Summary guidelines for research in this area are outlined, and suggestions and prospects for future developments are considered...
  6. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
    ..We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue...
  7. ncbi Drug-induced prolongation of the QT interval
    Dan M Roden
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    N Engl J Med 350:1013-22. 2004
  8. ncbi ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Com
    Douglas P Zipes
    J Am Coll Cardiol 48:e247-346. 2006
  9. ncbi Estimated radiation dose associated with cardiac CT angiography
    Jorg Hausleiter
    Department of Cardiology, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 München, Germany
    JAMA 301:500-7. 2009
    ..However, the potential risks due to exposure to ionizing radiation associated with CCTA have raised concerns...
  10. ncbi Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients
    Maria Teresa La Rovere
    Divisione di Cardiologia e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Pavia, Italy
    Circulation 107:565-70. 2003
    ....
  11. ncbi Cardiac-resynchronization therapy for mild-to-moderate heart failure
    Anthony S L Tang
    Island Medical Program, University of British Columbia, Vancouver, Canada
    N Engl J Med 363:2385-95. 2010
    ..Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to an ICD and optimal medical therapy might reduce mortality and morbidity among such patients...
  12. pmc Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 115:442-9. 2007
    ..We describe a new clinical entity that consists of an ST-segment elevation in the right precordial ECG leads, a shorter-than-normal QT interval, and a history of sudden cardiac death...
  13. ncbi Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
    W S Redfern
    Safety Assessment UK, AstraZeneca R and D Alderley Park, Macclesfield, Cheshire, UK
    Cardiovasc Res 58:32-45. 2003
    ..To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use...
  14. ncbi Epidermal electronics
    Dae Hyeong Kim
    Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Science 333:838-43. 2011
    ..We used this type of technology to measure electrical activity produced by the heart, brain, and skeletal muscles and show that the resulting data contain sufficient information for an unusual type of computer game controller...
  15. pmc Genome-wide association study of PR interval
    Arne Pfeufer
    Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Nat Genet 42:153-9. 2010
    ..0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation...
  16. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
    ..Given the importance and potential implications of these observations, we performed a study to more accurately quantify the contribution to SIDS of LQTS gene mutations and rare variants...
  17. ncbi Dilated cardiomyopathy
    John Lynn Jefferies
    Pediatric Cardiology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    Lancet 375:752-62. 2010
    ..Arrhythmia therapy and prevention of sudden death continue to be mainstays of treatment. Despite progress over the past 10 years, outcomes need to be improved...
  18. pmc Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    Nona Sotoodehnia
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Nat Genet 42:1068-76. 2010
    ..These findings extend our current knowledge of ventricular depolarization and conduction...
  19. ncbi Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT Investigators
    E Boersma
    University Hospital Rotterdam, Rotterdam, The Netherlands
    Circulation 101:2557-67. 2000
    ..Appropriate treatment policies should include an accurate estimate of a patient's baseline risk. Risk modeling to date has been underutilized in patients with acute coronary syndromes without persistent ST-segment elevation...
  20. ncbi Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition
    Stephan Achenbach
    Department of Cardiology, University of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
    Eur Heart J 31:340-6. 2010
    ..We evaluated the feasibility and image quality of a new scan mode for coronary computed tomography angiography (CTA) with an effective dose of less than 1 mSv...
  21. ncbi A real-time QRS detection method based on moving-averaging incorporating with wavelet denoising
    Szi Wen Chen
    Department of Electronic Engineering, Chang Gung University, Kwei Shan, Tao Yuan 333, Taiwan
    Comput Methods Programs Biomed 82:187-95. 2006
    ..5% of the detection rate for the standard database, and also, it could function reliably even under the condition of poor signal quality in the measured ECG data...
  22. pmc Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults
    Erik B Schelbert
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 308:890-6. 2012
    Unrecognized myocardial infarction (MI) is prognostically important. Electrocardiography (ECG) has limited sensitivity for detecting unrecognized MI (UMI).
  23. pmc Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)
    D Woodrow Benson
    Department of Pediatrics, Cincinnati Children s Hospital, Ohio, USA
    J Clin Invest 112:1019-28. 2003
    ..Our findings reveal a molecular basis for some forms of congenital SSS and define a recessive disorder of a human heart voltage-gated sodium channel...
  24. ncbi The use of the Hilbert transform in ECG signal analysis
    D Benitez
    Department of Instrumentation and Analytical Science, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester M60 1QD, UK
    Comput Biol Med 31:399-406. 2001
    ..A detection error rate of less than 0.8% was achieved in every study case. The reliability of the proposed detector compares very favorably with published results for other QRS detectors...
  25. ncbi Twenty-two year (1975 to 1997) trends in the incidence, in-hospital and long-term case fatality rates from initial Q-wave and non-Q-wave myocardial infarction: a multi-hospital, community-wide perspective
    M I Furman
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Am Coll Cardiol 37:1571-80. 2001
    ....
  26. pmc Electrocardiographic QT interval and mortality: a meta-analysis
    Yiyi Zhang
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Epidemiology 22:660-70. 2011
    ..However, the implications of variations in QT-interval length within normal limits for mortality in the general population are still unclear...
  27. ncbi Risk of arrhythmias in myotonic dystrophy: trial design of the RAMYD study
    Antonio Dello Russo
    Institute of Cardiology, Department of Cardiovascular Medicine, Catholic University, L go A Gemelli 8, 00168 Rome, Italy
    J Cardiovasc Med (Hagerstown) 10:51-8. 2009
    ....
  28. ncbi Low-dose, 128-slice, dual-source CT coronary angiography: accuracy and radiation dose of the high-pitch and the step-and-shoot mode
    Hatem Alkadhi
    University Hospital Zurich, Institute of Diagnostic Radiology, Raemistrasse 100, Zurich, Switzerland
    Heart 96:933-8. 2010
    ..To compare the diagnostic accuracy and radiation doses of two low-dose protocols for coronary artery imaging with second-generation, dual-source CT in comparison with catheter angiography (CA)...
  29. ncbi SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome
    Vincent Probst
    INSERM, UMR915, Nantes, France
    Circ Cardiovasc Genet 2:552-7. 2009
    ..However, in familial studies, the relationship between SCN5A mutations and BrS remains poorly understood. The aim of this study was to investigate the association of SCN5A mutations and BrS in a group of large genotyped families...
  30. ncbi Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm
    Raoul Stahrenberg
    Department of Cardiology and Pneumology, Universitatsmedizin Gottingen, 37075 Gottingen, Germany
    Stroke 41:2884-8. 2010
    ..Early initiation and prolongation of continuous Holter monitoring may improve diagnostic yield compared with the standard of care including a 24-hour Holter recording...
  31. ncbi An advanced detrending method with application to HRV analysis
    Mika P Tarvainen
    University of Kuopio, Department of Applied Physics, Finland
    IEEE Trans Biomed Eng 49:172-5. 2002
    ..The method is based on smoothness priors approach and operates like a time-varying finite-impulse response high-pass filter. The effect of the detrending on time- and frequency-domain analysis of HRV is studied...
  32. ncbi Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
    ..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
  33. pmc Diagnostic and prognostic utility of electrocardiography for left ventricular hypertrophy defined by magnetic resonance imaging in relationship to ethnicity: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Aditya Jain
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am Heart J 159:652-8. 2010
    ..Ethnicity is believed to affect electrocardiographic (ECG) performance. We evaluated the diagnostic and prognostic performance of ECG for left ventricular hypertrophy (LVH) as defined by MRI in relationship to ethnicity...
  34. ncbi Outcome parameters for trials in atrial fibrillation: executive summary
    Paulus Kirchhof
    Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Eur Heart J 28:2803-17. 2007
    ..In addition to a careful selection of a relevant primary outcome parameter, coverage of outcomes in all major domains of AF-related morbidity and mortality is desirable for any clinical trial in AF...
  35. ncbi A placebo-controlled trial of prucalopride for severe chronic constipation
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 358:2344-54. 2008
    ..In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation...
  36. ncbi Noninvasive coronary angiography by 320-row computed tomography with lower radiation exposure and maintained diagnostic accuracy: comparison of results with cardiac catheterization in a head-to-head pilot investigation
    Marc Dewey
    Charite, Medical School, Departments of Radiology, Humboldt Universitat zu Berlin, Freie Universitat Berlin, Berlin, Germany
    Circulation 120:867-75. 2009
    ..We evaluated coronary angiography using whole-heart 320-row CT, which avoids exposure-intensive overscanning and overranging...
  37. ncbi ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999
    Elliott M Antman
    Circulation 110:588-636. 2004
  38. pmc Arrhythmia ECG noise reduction by ensemble empirical mode decomposition
    Kang Ming Chang
    Department of Photonics and Communication Engineering, Asia University, Wufeng, Taichung County, 500, Lioufeng Rd, Wufeng, Taichung County, 41354, Taiwan
    Sensors (Basel) 10:6063-80. 2010
    ..Mean square error between clean and filtered ECGs was used as filtering performance indexes. Results showed that high noise reduction is the major advantage of the EEMD based filter, especially on arrhythmia ECGs...
  39. pmc Vertical P-wave axis: the electrocardiographic synonym for pulmonary emphysema and its severity
    Lovely Chhabra
    University of Massachusetts Medical School, Worcester, MA 01608, USA
    Indian Heart J 64:40-2. 2012
    ....
  40. ncbi Increased temporal dispersion of myocardial repolarization in myotonic dystrophy type 1: beyond the cardiac conduction system
    Damiano Magrì
    Cardiology Department, S Andrea Hospital, Sapienza University of Rome, Rome, Italy
    Int J Cardiol 156:259-64. 2012
    ..We also investigated the possible differences within DM1 patients by subdividing them according either to the presence of first degree atrioventricular block (1st AVB) or to the cytosine-thymine-guanine (CTG) repeat expansion size...
  41. ncbi A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill
    W Antoinette Groenewegen
    Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 92:14-22. 2003
    ..We propose that, although the functional effect of each genetic change is relatively benign, the combined effect of genetic changes eventually progresses to total AS...
  42. ncbi A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate
    Koonlawee Nademanee
    Pacific Rim Electrophysiology Research Institute, Inglewood, California 90301, USA
    J Am Coll Cardiol 43:2044-53. 2004
    ..We sought to test the hypothesis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be used as target sites for catheter ablation of AF...
  43. doi 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    Elliott M Antman
    J Am Coll Cardiol 51:210-47. 2008
  44. ncbi Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic
    L M Hondeghem
    Department of Pharmacology, Leuven, Belgium
    Circulation 103:2004-13. 2001
    ..Prolongation of action potential duration (APD) is considered a major antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic (torsade de pointes)...
  45. ncbi Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1
    William J Groh
    Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis 46202, USA
    N Engl J Med 358:2688-97. 2008
    ..Sudden death can occur as a consequence of cardiac-conduction abnormalities in the neuromuscular disease myotonic dystrophy type 1. The determinants of the risk of sudden death remain imprecise...
  46. pmc The human respiratory gate
    Dwain L Eckberg
    Department of Medicine, Hunter Holmes McGuire Department of Veterans Affairs Medical Center and Medical College of Virginia, Virginia Commonwealth University, Richmond, USA
    J Physiol 548:339-52. 2003
    ..I propose that the most enduring significance of respiratory gating is its use as a precisely controlled experimental tool to tease out and better understand otherwise inaccessible human autonomic neurophysiological mechanisms...
  47. ncbi Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating
    Lars Husmann
    Department of Medical Radiology and Cardiovascular Center, University Hospital Zurich, Raemistr 100, CH 8091 Zurich, Switzerland
    Eur Heart J 29:191-7. 2008
    ..To determine the feasibility of prospective electrocardiogram (ECG)-gating to achieve low-dose computed tomography coronary angiography (CTCA)...
  48. pmc Acute exposure to environmental tobacco smoke and heart rate variability
    C A Pope
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
    Environ Health Perspect 109:711-6. 2001
    ..Altered cardiac autonomic function, assessed by decrements in HRV, is associated with acute exposure to ETS and may be part of the pathophysiologic mechanisms linking ETS exposure and increased cardiac vulnerability...
  49. ncbi STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry)
    Gilles Montalescot
    Institut de Cardiologie and INSERM U856, Pitie Salpetriere University Hospital, AP HP, 47 Boulevard de l Hopital, Paris 75013, France
    Eur Heart J 28:1409-17. 2007
    ..The aim of this study was to describe the management and outcomes using 'real-world' data taking the new definition of acute myocardial infarction into account...
  50. pmc Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression
    Willem J Kop
    Department of Medicine, Division of Cardiology, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Psychosom Med 72:626-35. 2010
    ..To investigate prospectively whether autonomic nervous system (ANS) dysfunction and inflammation play a role in the increased cardiovascular disease (CVD)-related mortality risk associated with depression...
  51. ncbi Dispersion of repolarization and beta-thalassemia major: the prognostic role of QT and JT dispersion for identifying the high-risk patients for sudden death
    Vincenzo Russo
    Chair of Cardiology, Second University of Naples, Naples, Italy
    Eur J Haematol 86:324-31. 2011
    ..The aim of our study was to evaluate the heterogeneity of ventricular repolarization in patients with beta-thalassemia and to test the hypothesis that an abnormal QTc and JTc dispersion may predict SCD in this population...
  52. pmc ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis
    David G Strauss
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Circ Arrhythm Electrophysiol 1:327-36. 2008
    ....
  53. pmc Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node
    Maria M Kreuzberg
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Romerstrasse 164, 53117 Bonn, Germany
    Proc Natl Acad Sci U S A 103:5959-64. 2006
    ..g., atrial fibrillation) by preventing rapid conduction to the ventricles potentially associated with hemodynamic deterioration...
  54. ncbi Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis
    Anne Royer
    INSERM U533, Institut du Thorax, Faculte de Medecine, Nantes, France
    Circulation 111:1738-46. 2005
    ..In the present study, we investigated heterozygous Scn5a-knockout mice (Scn5a+/- mice) as a model for hereditary Lenègre's disease...
  55. ncbi Defining left bundle branch block in the era of cardiac resynchronization therapy
    David G Strauss
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Cardiol 107:927-34. 2011
    ..Further studies are needed to reinvestigate the electrocardiographic criteria for complete LBBB and the implications of these criteria for selecting patients for CRT...
  56. ncbi Long-term follow-up of arrhythmias in patients with myotonic dystrophy treated by pacing: a multicenter diagnostic pacemaker study
    Arnaud Lazarus
    Service de Cardiologie et de Biostatistique, Hopital Cochin, Paris, France
    J Am Coll Cardiol 40:1645-52. 2002
    ....
  57. ncbi Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial
    Michael Bohm
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Lancet 376:886-94. 2010
    ..We aimed to test our hypothesis by investigating the association between heart rate and events in this patient population...
  58. ncbi Arrhythmogenic right ventricular cardiomyopathy
    Cristina Basso
    University of Padua Medical School, Padua, Italy
    Lancet 373:1289-300. 2009
    ..Cascade genetic screening of family members of gene-positive probands allows the identification of asymptomatic carriers who would require lifelong follow-up due to the age-related penetrance...
  59. ncbi The many metrics of cardiac chronotropy: a pragmatic primer and a brief comparison of metrics
    John J B Allen
    Department of Psychology, University of Arizona, Tucson, AZ 85721 0068, USA
    Biol Psychol 74:243-62. 2007
    ..Although generally highly correlated, the various metrics responded differently under challenge...
  60. pmc Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice
    Vesna Nikolova
    Molecular Cardiology Program, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    J Clin Invest 113:357-69. 2004
    ..Despite severe DCM, defects in nuclear function prevent Lmna(-/-) cardiomyocytes from developing compensatory hypertrophy and accelerate disease progression...
  61. ncbi Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression
    Srijita Sen-Chowdhry
    The Heart Hospital, University College London, United Kingdom
    Circulation 115:1710-20. 2007
    ..We hypothesized that unbiased representation of the spectrum of disease expression in arrhythmogenic right ventricular dysplasia/cardiomyopathy would require in vivo assessment of families in a genetically heterogeneous population...
  62. ncbi The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    Baofeng Yang
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150086, China
    Nat Med 13:486-91. 2007
    ..1) and GJA1 (which encodes connexin 43), and this likely accounts at least in part for its arrhythmogenic potential. Thus, miR-1 may have important pathophysiological functions in the heart, and is a potential antiarrhythmic target...
  63. ncbi Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Muenster, Germany
    Circulation 114:1799-806. 2006
    ..To test the hypothesis that reduced desmosomal protein expression causes ARVC, we studied the cardiac effects of heterozygous plakoglobin deficiency in mice...
  64. ncbi Sudden cardiac arrest associated with early repolarization
    Michel Haissaguerre
    Universite Bordeaux, Hopital Haut Leveque, Bordeaux Pessac, France
    N Engl J Med 358:2016-23. 2008
    ..Its potential to cause cardiac arrhythmias has been hypothesized from experimental studies, but it is not known whether there is a clinical association with sudden cardiac arrest...
  65. pmc Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials
    Nejib Zemzemi
    Department of Computer Science, University of Oxford, Oxford, UK
    Br J Pharmacol 168:718-33. 2013
    ..Here our goal is to demonstrate the ability of computational models to simulate the effect of drug action on the electrical activity of the heart, at the level of the ion-channel, cell, heart and ECG body surface potential...
  66. ncbi Underdiagnosis of myocardial infarction in COPD - Cardiac Infarction Injury Score (CIIS) in patients hospitalised for COPD exacerbation
    Pål H Brekke
    Department of Medicine and Faculty Division, Akershus University Hospital, N 1478 Lørenskog, Norway
    Respir Med 102:1243-7. 2008
    ..We used Cardiac Infarction Injury Score (CIIS) to assess the prevalence of prior myocardical infarction (MI) in COPD patients and compared this to clinicians' previous diagnosis of MI...
  67. pmc Association of major and minor ECG abnormalities with coronary heart disease events
    Reto Auer
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    JAMA 307:1497-505. 2012
    ..Electrocardiographic (ECG) abnormalities are common in older adults and might be of value for CHD prediction...
  68. ncbi Divergent electrocardiographic responses to whole and particle-free diesel exhaust inhalation in spontaneously hypertensive rats
    Christina M Lamb
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Toxicol Sci 125:558-68. 2012
    ..g., gases), whereas others (e.g., PM) trigger delayed effects potentially via separate mechanisms...
  69. ncbi Electrocardiographic characteristics in a population with high rates of seropositivity for Trypanosoma cruzi infection
    S Williams-Blangero
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Am J Trop Med Hyg 77:495-9. 2007
    ..Results indicate that T. cruzi infection and subsequent Chagas disease will continue to be major health problems for the foreseeable future in this typical rural area of Brazil...
  70. ncbi QRS complexes detection for ECG signal: the Difference Operation Method
    Yun Chi Yeh
    Department of Electrical Engineering, National Central University, Jhongli 320, Taiwan, ROC
    Comput Methods Programs Biomed 91:245-54. 2008
    ..Some records (QRS complex and T and P waves) of ECG signals in MIT-BIH arrhythmia database is tested to show the DOM has a much more precise detection rate and faster speed than other methods...
  71. ncbi Motion in cardiovascular MR imaging
    Andrew D Scott
    Cardiovascular Magnetic Resonance Unit, The Royal Brompton Hospital, London, England
    Radiology 250:331-51. 2009
    ..Similarly, for respiratory motion of the heart, techniques such as breath holding, respiratory gating, section tracking, phase-encoding ordering, subject-specific translational models, and a range of new techniques are considered...
  72. ncbi Impact of teaching and assessment format on electrocardiogram interpretation skills
    Tobias Raupach
    Department of Cardiology and Pneumology, University Hospital Gottingen, Gottingen, Germany
    Med Educ 44:731-40. 2010
    ..This study assessed whether small-group peer teaching is more effective than lectures in enhancing medical students' ECG interpretation skills. In addition, the impact of assessment format on study outcome was analysed...
  73. ncbi Multiscale entropy analysis of pulse wave velocity for assessing atherosclerosis in the aged and diabetic
    Hsien Tsai Wu
    Department of Electrical Engineering, National Dong Hwa University, Hualien 97401, Taiwan
    IEEE Trans Biomed Eng 58:2978-81. 2011
    ..A self-developed six-channel electrocardiography (ECG)-PWV-based equipment was used to acquire 1000 successive recordings of PWV(foot) values within 30 min...
  74. ncbi Expansion of a regional ST-segment-elevation myocardial infarction system to an entire state
    James G Jollis
    Duke Clinical Research Institute, Duke University, Durham, NC 27710, USA
    Circulation 126:189-95. 2012
    ..Despite national guidelines calling for timely coronary artery reperfusion, treatment is often delayed, particularly for patients requiring interhospital transfer...
  75. pmc Comparison of exercise electrocardiography and stress perfusion CMR for the detection of coronary artery disease in women
    Simon Greulich
    Robert Bosch Medical Center, Auerbachstrasse 110, 70376, Stuttgart, Germany
    J Cardiovasc Magn Reson 14:36. 2012
    Exercise electrocardiography (ECG) is frequently used in the work-up of patients with suspected coronary artery disease (CAD), however the accuracy is reduced in women...
  76. ncbi Intraventricular conduction delay in a standard 12-lead electrocardiogram as a predictor of mortality in the general population
    Aapo L Aro
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Circ Arrhythm Electrophysiol 4:704-10. 2011
    ..In particular, there is a paucity of data on the prognostic significance of nonspecific intraventricular conduction delay in apparently healthy subjects...
  77. ncbi Electrocardiographic detection of emphysema
    Anish J Thomas
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 107:1090-2. 2011
    ..The specificity was increased when combined with a shortened QRS duration, at the cost of the sensitivity...
  78. pmc Accuracy of electrocardiography in diagnosis of left ventricular hypertrophy in arterial hypertension: systematic review
    Daniel Pewsner
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, CH 3012 Berne, Switzerland
    BMJ 335:711. 2007
    To review the accuracy of electrocardiography in screening for left ventricular hypertrophy in patients with hypertension.
  79. ncbi Six-channel ECG-based pulse wave velocity for assessing whole-body arterial stiffness
    Hsien Tsai Wu
    Department of Electrical Engineering, National Dong Hwa University, Hualien, Taiwan
    Blood Press 21:167-76. 2012
    ..We investigated the validity of applying a six-channel electrocardiogram-based pulse wave velocity (ECG-PWV) measurement system for this purpose...
  80. ncbi Wavelet transforms and the ECG: a review
    Paul S Addison
    CardioDigital Ltd, Elvingston Science Centre, East Lothian, UK
    Physiol Meas 26:R155-99. 2005
    ..In this review, the emerging role of the wavelet transform in the interrogation of the ECG is discussed in detail, where both the continuous and the discrete transform are considered in turn...
  81. ncbi Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease
    Raymond Y Kwong
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Masssachusetts 02115, USA
    Circulation 113:2733-43. 2006
    ..However, the prognostic significance of unrecognized myocardial scar by CMR in patients without a history of MI is unknown...
  82. ncbi Effect on treatment delay of prehospital teletransmission of 12-lead electrocardiogram to a cardiologist for immediate triage and direct referral of patients with ST-segment elevation acute myocardial infarction to primary percutaneous coronary interventi
    Maria Sejersten
    Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Denmark
    Am J Cardiol 101:941-6. 2008
    ..Ambulance transport seems safe despite longer transport times...
  83. pmc Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death
    Larisa G Tereshchenko
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circ Arrhythm Electrophysiol 5:719-27. 2012
    ..The goal of the present study was to determine the predictive value of beat-to-beat QT variability in heart failure patients across the continuum of left ventricular dysfunction...
  84. ncbi Automatic classification of heartbeats using ECG morphology and heartbeat interval features
    Philip de Chazal
    Department of Electronic and Electrical Engineering, University College Dublin, Belfield, Dublin 4, Ireland
    IEEE Trans Biomed Eng 51:1196-206. 2004
    ..For the VEB class, the sensitivity was 77.7%, the positive predictivity was 81.9%, and the false positive rate was 1.2%. These results are an improvement on previously reported results for automated heartbeat classification systems...
  85. pmc Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy
    Takeshi Suzuki
    Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e35353. 2012
    ..In order to address this issue, properties of the myocardium and underlying gene expressions were studied using a knock-in mouse model of human inherited DCM caused by a deletion mutation ΔK210 in cardiac troponinT...
  86. pmc A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project
    Fabio Marroni
    Institute of Genetic Medicine, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany
    Circ Cardiovasc Genet 2:322-8. 2009
    ..We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations...
  87. ncbi Long-term outcome associated with early repolarization on electrocardiography
    Jani T Tikkanen
    Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland
    N Engl J Med 361:2529-37. 2009
    ..by an elevation of the QRS-ST junction (J point) in leads other than V(1) through V(3) on 12-lead electrocardiography, has been associated with vulnerability to ventricular fibrillation, but little is known about the ..
  88. ncbi Radiation dose reduction and coronary assessability of prospective electrocardiogram-gated computed tomography coronary angiography: comparison with retrospective electrocardiogram-gated helical scan
    Takao Maruyama
    Department of Cardiology, Kawasaki Hospital, Kobe, Japan
    J Am Coll Cardiol 52:1450-5. 2008
    ....
  89. ncbi Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus
    P Rossing
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 18:199-205. 2001
    ..To evaluate prolonged QTc interval and QT dispersion as predictors of all-cause and cardiovascular mortality after adjustment for well-established risk factors in Type 1 diabetic patients...
  90. pmc Prosthetic heart valve assessment with multidetector-row CT: imaging characteristics of 91 valves in 83 patients
    Jesse Habets
    Department of Radiology, UMC Utrecht, P O Box 85500, E01 132, 3508, GA, Utrecht, The Netherlands
    Eur Radiol 21:1390-6. 2011
    ..Multidetector CT (MDCT) has shown potential for prosthetic heart valve (PHV) assessment. We assessed the image quality of different PHV types to determine which valves are suitable for MDCT evaluation...
  91. pmc Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria
    Frank I Marcus
    University of Arizona, Tucson, AZ, USA
    Eur Heart J 31:806-14. 2010
    ..Consequently, the 1994 criteria were highly specific but lacked sensitivity for early and familial disease...
  92. ncbi Assessment of clinical features in transient left ventricular apical ballooning
    Yoshiteru Abe
    Division of Cardiology, Shimada Municipal Hospital, Shimada, Shizuoka, Japan
    J Am Coll Cardiol 41:737-42. 2003
    ..We sought to assess the clinical features of transient left ventricular (LV) apical ballooning...
  93. ncbi Mechanisms for discordant alternans
    M A Watanabe
    Physics Department, Northeastern University, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 12:196-206. 2001
    ..CONCLUSION: Spatial inhomogeneities of electrical restitution properties are not required to produce discordant alternans...
  94. pmc Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy
    Kalliopi Pilichou
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padua, 35121 Padua, Italy
    J Exp Med 206:1787-802. 2009
    ..Insight into mechanisms initiating myocardial damage in ARVC is a prerequisite to the future development of new therapies aimed at delaying onset or progression of the disease...
  95. ncbi Mutational spectrum in the Ca(2+)--activated cation channel gene TRPM4 in patients with cardiac conductance disturbances
    Birgit Stallmeyer
    Institut für Genetik von Herzerkrankungen, Universitatsklinikum Munster, Munster, Germany
    Hum Mutat 33:109-17. 2012
    ..The phenotypes are variable and clearly suggestive of additional factors modulating the disease phenotype in some patients...
  96. ncbi Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT: technique and initial experience
    Michael Lell
    Diagnostic Radiology, University of Erlangen, Erlangen, Germany
    Eur Radiol 19:2576-83. 2009
    ..We evaluated radiation exposure and image quality of a new coronary CT angiography protocol, high-pitch spiral acquisition, using dual source CT (DSCT)...
  97. ncbi Dry and noncontact EEG sensors for mobile brain-computer interfaces
    Yu Mike Chi
    Department of Electrical and Computer Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA 92093, USA
    IEEE Trans Neural Syst Rehabil Eng 20:228-35. 2012
    ..The results of these experiments show that both dry and noncontact electrodes, with further development, may become a viable tool for both future mobile BCI and general EEG applications...
  98. ncbi Recommendations for interpretation of 12-lead electrocardiogram in the athlete
    Domenico Corrado
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Via Giustiniani 2, Padova, Italy
    Eur Heart J 31:243-59. 2010
    ..of an international panel of cardiologists and sports medical physicians with expertise in the fields of electrocardiography, imaging, inherited cardiovascular disease, cardiovascular pathology, and management of young competitive ..
  99. ncbi Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval
    Hsien C Cheng
    Safety Pharmacology, Drug Safety Evaluation, Sanofi Aventis, Bridgewater, NJ 08807, USA
    J Pharmacol Toxicol Methods 54:278-87. 2006
    ..Since QT intervals can be generated from paced or spontaneously beating hearts, data so generated can also be used for validating QT(c) correction equations...
  100. pmc Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome
    John R Giudicessi
    Department of Medicine Division of Cardiovascular Diseases, Department of Pediatrics Division of Pediatric Cardiology, and Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, USA
    Heart Rhythm 8:1024-32. 2011
    ..Given the prominent role of the transient outward current (I(to)) in BrS pathogenesis, we hypothesized that rare gain-of-function mutations in KCND3 may serve as a pathogenic substrate for BrS...

Research Grants75

  1. Update and modification of Task Force Criteria for ARVD/C
    Frank Marcus; Fiscal Year: 2007
    ..several members from the original Task Force on ARVD/C, and current experts in the imaging modalities, electrocardiography and pathology who have a major interest in ARVD/C...
  2. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..abstract_text> ..
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  4. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  5. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..We propose to show its usefulness as a monitor of sleep in health, in those with simple and complicated forms of sleep apnea, and in patients with heart failure. ..
  6. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..analysis;cardiac structure and function by echocardiography;and conduction defects and arrhythmias by electrocardiography. Likewise, we will analyze trophic (myocyte), proliferative and reparative (fibroblasts) responses of cells ..
  7. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..These data will be important to patients and their physicians in developing new interventions for managing type 1 diabetes and to public health practitioners charged with delivering preventive care. ..
  8. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..Specifically, NINDS support is for the expansion of the case ascertainment to include cases of SUDEP in individuals under the age of 24 in up to 15 states. ..
  9. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2012
    ..In Aim 1, vagotomy is used in conjunction with simultaneous video electroencephalography- electrocardiography (EEG-ECG) to assess the effect of parasympathetic neurotransmission on cardiac dysfunction and premature ..
  10. The Race-Specific Prevalence of Atrial Fibrillation Measured by 48-Hour Holter
    LAURA L LOEHR; Fiscal Year: 2013
    ..Most prior studies have defined AF by self-report, hospitalizations, claims data, and/or 12-lead electrocardiography, all of which may miss subclinical and intermittent AF...
  11. Three-dimensional cardiac accelerometry for cardiac monitoring
    Michael J Russell; Fiscal Year: 2010
    ..The cardiac stress test is the standard screening tool for assessing cardiac function, and electrocardiography (ECG), ultrasound (echocardiography, ECHO) and nuclear myocardial perfusion imaging (MPI) are the ..
  12. Home ECG Monitoring to Detect Allograft Rejection Following Heart Transplantation
    Barbara J Drew; Fiscal Year: 2013
    ..The public health benefit of detecting a simple ECG marker of heart transplant rejection is that it might yield earlier detection, allow more timely initiation of medical therapy and reduce mortality from acute rejection. ..
  13. Screening for Jervell and Lange-Nielsen Syndrome
    Ruey Kang R Chang; Fiscal Year: 2010
    ..We propose an innovative approach to early diagnosis of JLNS by cardiac screening of all infants who are identified with sensorineural hearing loss by the California Newborn Hearing Screening Program. ..
  14. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2013
    ..In Aim 1, vagotomy is used in conjunction with simultaneous video electroencephalography- electrocardiography (EEG-ECG) to assess the effect of parasympathetic neurotransmission on cardiac dysfunction and premature ..
  15. PROMISE Trial: SDCC
    Kerry L Lee; Fiscal Year: 2013
    ..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
  16. PROMISE Trial: EQOL Coordinating Center
    Daniel B Mark; Fiscal Year: 2013
    ..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
  17. PROMISE Trial: Clinical Coordinating Center
    Pamela Susan Douglas; Fiscal Year: 2013
    ..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
  18. Genomics of Cardiac Electrical Activity and Arrhythmia
    Nona Sotoodehnia; Fiscal Year: 2013
    ..Importantly, we then translae these genetic associations into functional studies, to understand the role in cardiac electrophysiology and arrhythmias played by the genes and variants identified. ..
  19. Medical Consequences of Long-Term Anabolic-Androgenic Steroid Abuse
    Harrison G Pope; Fiscal Year: 2013
    ..In a pilot study, now in press, our group used electrocardiography and echocardiography to compare 12 long- term AAS users, aged 32-46 years, and 7 age-matched weightlifters ..
  20. Detection and Alerting System for Seizure Onset (DASSO)
    Todd A Summers; Fiscal Year: 2013
    ....
  21. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ....
  22. Molecular Determinants of K+ Channel Regulation in Heart
    Robert S Kass; Fiscal Year: 2013
    ....
  23. PROMISE Trial: Dx Core
    Udo Hoffmann; Fiscal Year: 2013
    ..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
  24. Rituximab Therapy in Refractory Adult and Juvenile IIM
    CHARLES ODDIS; Fiscal Year: 2009
    ..abstract_text> ..
  25. Rituximab Therapy in Refractory Adult and Juvenile IIM
    CHARLES ODDIS; Fiscal Year: 2010
    ..abstract_text> ..
  26. Prevention and Risk Identification of SUDEP Mortality - the PRISM Project
    Samden Lhatoo; Fiscal Year: 2013
    ..and analysis of very large datasets of multi-modal seizure data (video, electroencephalography (EEG), electrocardiography (EKG), blood pressure, O2 &CO2 measurements, sleep data);traditional visual and statistical analyses of ..
  27. Connexin 43 gap junction dynamics in the diabetic heart
    Joseph A Palatinus; Fiscal Year: 2013
    ..In addition cardiac function will be assessed using electrocardiography, echocardiography and optical mapping of fluorescent voltage sensitive dyes...
  28. RODENT PHENOTYPING CORE &OTHER TECHNICAL CORES
    RALPH VICTOR SHOHET; Fiscal Year: 2011
    ..methods now include blood pressure measurements, (invasive, implanted and non-invasive), echocardiography, electrocardiography, and invasive hemodynamics...
  29. AN INNOVATIVE ULTRASOUND-BASED PROSPECTIVE-GATING TECHNIQUE FOR CARDIAC COMPUTED
    Srini Tridandapani; Fiscal Year: 2013
    ..The PI hypothesizes that US, which provides real-time data similar to electrocardiography (ECG), can directly evaluate cardiac mechanical motion and would be more reliable than ECG at determining ..
  30. Reversing the Autonomic Nervous System Imbalance in Overweight Individuals
    GENEVIEVE ANNA WOODARD; Fiscal Year: 2010
    ..At 6 months, those with the largest restoration in autonomic balance will have lower PWV, thinner IMT and smaller AD. ..
  31. Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin
    Francisco J Villarreal; Fiscal Year: 2013
    ..abstract_text> ..
  32. Mechanisms linking hot flashes to cardiovascular risk
    Rebecca C Thurston; Fiscal Year: 2013
    ..women will undergo 3 days of physiologic hot flash monitoring, 24 hours of which will include ambulatory electrocardiography for measurement of cardiac vagal control (high frequency heart rate variability), a brachial artery ..
  33. Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol
    Richard E Peltier; Fiscal Year: 2013
    ..Brionchial lavage fluid will be collected and centrifuged and the supernatant will be analyzed for biochemical indicators of lung injury (total protein and LDH) and inflammatory cytokines. ..
  34. Predicting Adverse Cardiovascular Events in Emergencies Due to Drug Overdose
    ALEX FRANCIS MANINI; Fiscal Year: 2013
    ..S., and the leading cause of cardiac arrest in victims under 40 years of age. There are 2.4 million reported poison exposures and approximately 1.5 million drug-related emergencies in the U.S. annually. ..
  35. MODULATION OF CARDIAC REPOLARIZATION
    Dan M Roden; Fiscal Year: 2013
    ..Understanding mechanisms underlying arrhythmia susceptibility may lead to improved preventive treatments. ..
  36. Exercise Stress Cardiovascular Magnetic Resonance
    ORLANDO PAUL SIMONETTI; Fiscal Year: 2013
    ..affords for the first time measurement of myocardial perfusion, diastolic function, systolic function, electrocardiography, myocardial edema and exertional symptoms - the complete ischemic cascade - in one test...
  37. Melanocortin Ligands in Disease Cachexia
    KENNETH ALLEN GRUBER; Fiscal Year: 2013
    ..Tensive Controls will complete the work necessary to develop anti-cachexia therapeutic, and move it into formal pre-clinical development. This will produce an anti-cachexia drug that will increase the treatment window for malignancies. ..
  38. The Genetic Basis of Novel Loci Influencing Myocardial Repolarization
    David J Milan; Fiscal Year: 2010
    ....
  39. A Personal, Nonobtrusive System for Tracking Arterial Blood Pressure at Home
    Vladimir Shusterman; Fiscal Year: 2013
    ..The first application of the system is for nighttime AP tracking at home. ..
  40. Microfluidic devices for high-throughput anthelmintic screens
    Shawn R Lockery; Fiscal Year: 2010
    ..This goal of project is to reduce the cost of finding new anti- nematode drugs by developing a new screening process that combines microtechnology and electrophysiology for the first time. ..
  41. Cardioscopy New Platform for Less Invasive Surgery on the Beating Heart
    Tomislav Mihaljevic; Fiscal Year: 2013
    ..This technique could replace many invasive surgical procedures that require a sternotomy, eliminate added risks from re-operations and provide a safer approach for high risk and elderly patients with valve regurgitation. ..
  42. Therapeutic Microlesioning by Contrast Echocardiography for Myocardial Reduction
    Oliver D Kripfgans; Fiscal Year: 2013
    ..Echocardiography together with electrocardiography is the gold standard for diagnosis and treatment follow-up for HCM...
  43. A Phase 3, Double-Blind Efficacy, Safety and Dose-Response Study of Lofexidine (S
    Charles W Gorodetzky; Fiscal Year: 2013
    ..NIDA's support of this development work on lofexidine is necessary to enable FDA approval of the first non-narcotic, non-addictive treatment for opioid withdrawal. ..
  44. PROMISE Trial: Substudy to Assess for Effective Dose of Radiation
    ANDREW EINSTEIN; Fiscal Year: 2013
    ..testing strategy (using physician-selected stress imaging (MPS or echocardiography) or stress electrocardiography)) in low-intermediate CAD risk patients with chest pain...
  45. The Safe Fetus Project
    ADAM JOHN WOLFBERG; Fiscal Year: 2012
    ..Our goal is to develop technology that makes pregnancy and labor safer, by identifying changes in the fetal electrocardiogram or heart rate that predict injury to the fetus or newborn. ..
  46. Exploring the Feasibility of Computational Markers to Predict Atrial Fibrillation
    JAMES MARLOW BLUM; Fiscal Year: 2013
    ..These approaches will be validated on the data collected in Aim 1, and will be used to develop models based on non-parametric machine learning techniques to accurately assess PAF risk. ..
  47. A Low-Cost Cardiac Annunciator to Reduce Stillbirths and Neonatal Deaths
    Michael R Neuman; Fiscal Year: 2013
    ....
  48. Betahistine: Novel Therapeutic in Attention Deficit Hyperactivity Disorder
    CHARLES PIERCE; Fiscal Year: 2009
    ..This Phase 1 SBIR proposal will determine the safety, tolerability, and pharmacokinetics of higher doses of betahistine and characterize dose-response for improving attention and impulsivity in young adults with ADHD. ..
  49. Vanderbilt Genome-Electronic Records Project
    Dan M Roden; Fiscal Year: 2011
    ....
  50. PLASTICITY OF THE SYSTEMIC INFLAMMATORY RESPONSE
    J Perren Cobb; Fiscal Year: 2011
    ..In addition, we seek to better understand the response of white blood cells to infection and to identify new therapeutic targets. ..
  51. Noninvasive arrhythmia mapping using Electromechanical Wave Imaging
    Elisa E Konofagou; Fiscal Year: 2013
    ..Furthermore, it can also be applied safely and noninvasively in conjunction with any diagnostic method, such as electrocardiography and echocardiography or, monitoring of therapeutic techniques.
  52. Phase 2 Study of Magnesium Supplements in the Treatment of PXE
    Mark Lebwohl; Fiscal Year: 2013
    ..Upon completion of the first year, barring any safety concerns, all subjects will be administered magnesium supplements for up to one additional year. The same evaluations/procedures will be conducted during Part 2. ..
  53. EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHY
    Elisa E Konofagou; Fiscal Year: 2013
    ....
  54. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2013
    ..3) To investigate the coupling between electrical excitation and mechanical contraction in the normal human heart, its alteration in heart failure and modification by cardiac resynchronization therapy (CRT) in the failing heart. ..
  55. FMRI of Autonomic Regulation with Acupuncture
    KYUNGMO PARK; Fiscal Year: 2010
    ..b>Electrocardiography (ECG) and pupilometry will be recorded simultaneously with fMRI...
  56. ARRHYTHMOGENIC ACTIONS OF ANTIHISTAMINES
    Raymond Woosley; Fiscal Year: 1999
    ..This information will enable physicians to identify patients at risk for adverse response to these actions. Also, the appropriate treatment of patients with intentional or accidental overdose of antihistamines can be determined. ..
  57. QTRR Dynamic Coupling in Patients with the Long QT Syndrome
    JEAN PHILIPPE Y COUDERC; Fiscal Year: 2013
    ..Ultimately, we aim to improve the prognosis and management of LQTS patients. ..
  58. Noninvasive conduction mapping using Electromechanical Wave Imaging
    Elisa E Konofagou; Fiscal Year: 2010
    ..it can also be applied safely and noninvasively in conjunction with any diagnostic method, such as electrocardiography and echocardiography or, monitoring of therapeutic techniques, such as Cardiac Resynchronization Therapy (..
  59. Improving Rural Healthcare Transitions Through Health Information Exchange
    Kenneth E Wood; Fiscal Year: 2013
    ....
  60. Fetal Magnetocardiography Using Non-cryogenic Magnetic Field Sensors
    VISHAL K SHAH; Fiscal Year: 2012
    ..Postnatally, electrocardiography (ECG) is the gold standard for rhythm assessment...
  61. IDENTIFYING HIGH RISK PATIENTS WITH SYNCOPE
    Wishwa Kapoor; Fiscal Year: 1991
    ..Furthermore, these models will lead to future studies investigating the impact of various treatment interventions in these high risk groups...
  62. Multisite Spatiotemporal Control of Cardiac Alternans
    UCHE KANU; Fiscal Year: 2010
    ..This research will help investigators better understand this cardiac disturbance as well as provide clinically viable techniques capable of preventing/terminating this potentially dangerous occurrence. ..
  63. Robust Cardiac Self-Gating For Fetal Cardiac MRI
    Peng Hu; Fiscal Year: 2013
    ..The developed strategies will then be evaluated on a cohort of pregnant women who are referred to fetal ultrasound for suspected congenital heart disease. ..
  64. IDIOPATHIC DILATED CARDIOMYOPATHY
    Virginia Michels; Fiscal Year: 1991
    ..Medical histories of 1st degree relatives will be obtained; these relatives will be studied by electrocardiography and M-mode, 2-dimensional, and Doppler echocardiography and will have levels of ANP determined...
  65. FUNCTIONAL CHARACTERISTICS OF THE LEFT HEART
    HAROLD DODGE; Fiscal Year: 1990
    ..Factors influencing the rate of lysis and rethrombosis following thrombolytic therapy are being identified...
  66. Bupropion VS Placebo to Treat Pathological Gambling
    Donald Black; Fiscal Year: 2004
    ..abstract_text> ..
  67. DYNAMICS OF RETINOPATHY AMONG MEXICAN AMERICAN DIABETICS
    Craig Hanis; Fiscal Year: 1990
    ..Such results will suggest intermediate points at which intervention could be aimed to alter the progression and lessen the impact of retinopathy...
  68. DIAGNOSIS OF CHEST PAIN AND CARE IN RURAL HOSPITALS
    John Westfall; Fiscal Year: 2000
    ..abstract_text> ..
  69. AUTONOMIC NERVOUS SYSTEM FUNCTIONING IN THE HUMAN FETUS
    Lynn Groome; Fiscal Year: 1999
    ....
  70. MASSAGE THERAPY FOR PATIENTS WITH HIV-1
    Thomas Birk; Fiscal Year: 1993
    ..A four by two design utilizing analysis of variance (ANOVA) with repeated measures will be used for statistical treatment of the data. The 0.05 level of significance will be used to reject the null hypothesis. ..
  71. EMS Based TIPI-IS Cardiac Care QI/Error Reduction System
    HARRY SELKER; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  72. CARDIAC AUTONOMIC CONTROL IN CHILDREN OF HIV+ MOTHERS
    Steven Lipshultz; Fiscal Year: 1993
    ....
  73. Dynamic ECG Predictors of Sudden Cardiac Death in Ischemia Cardiomyopathy
    Mary Carey; Fiscal Year: 2007
    ..Thus, the candidates' strengths in electrocardiography prepare her well for the proposal while expanding her expertise to analyze repolarization abnormalities in ..
  74. Novel Pharmacological Strategies in Autism
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