Genomes and Genes
Summary: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Publications317 found, 100 shown here
- The electrocardiogram predicts one-year outcome of patients with unstable angina and non-Q wave myocardial infarction: results of the TIMI III Registry ECG Ancillary Study. Thrombolysis in Myocardial IschemiaC P Cannon
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 30:133-40. 1997..We sought to determine the prognostic value of the admission electrocardiogram (ECG) in patients with unstable angina and non-Q wave myocardial infarction (MI)...
- Heart rate variability: origins, methods, and interpretive caveatsG G Berntson
Department of Psychology, Ohio State University, Columbus 43210, USA
Psychophysiology 34:623-48. 1997..Summary guidelines for research in this area are outlined, and suggestions and prospects for future developments are considered...
- Universal definition of myocardial infarctionKristian Thygesen
Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Aarhus C, Denmark
Eur Heart J 28:2525-38. 2007
- A model for human ventricular tissueK H W J ten Tusscher
Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
Am J Physiol Heart Circ Physiol 286:H1573-89. 2004..We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue...
- Universal definition of myocardial infarctionKristian Thygesen
Department of Medicine and Cardiology, Aarhus University Hospital, Tage Hansens, Gade 2, DK 8000 Aarhus C, Denmark
J Am Coll Cardiol 50:2173-95. 2007
- Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug developmentW S Redfern
Safety Assessment UK, AstraZeneca R and D Alderley Park, Macclesfield, Cheshire, UK
Cardiovasc Res 58:32-45. 2003..To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use...
- ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999Elliott M Antman
Circulation 110:588-636. 2004
- Epidermal electronicsDae Hyeong Kim
Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Science 333:838-43. 2011..We used this type of technology to measure electrical activity produced by the heart, brain, and skeletal muscles and show that the resulting data contain sufficient information for an unusual type of computer game controller...
- Genome-wide association study of PR intervalArne Pfeufer
Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
Nat Genet 42:153-9. 2010..0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation...
- Prevalence of long-QT syndrome gene variants in sudden infant death syndromeMarianne Arnestad
Institute of Forensic Medicine, University of Oslo, Oslo, Norway
Circulation 115:361-7. 2007..Given the importance and potential implications of these observations, we performed a study to more accurately quantify the contribution to SIDS of LQTS gene mutations and rare variants...
- Dilated cardiomyopathyJohn Lynn Jefferies
Pediatric Cardiology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
Lancet 375:752-62. 2010..Arrhythmia therapy and prevention of sudden death continue to be mainstays of treatment. Despite progress over the past 10 years, outcomes need to be improved...
- Estimated radiation dose associated with cardiac CT angiographyJorg Hausleiter
Department of Cardiology, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstrasse 36, 80636 München, Germany
JAMA 301:500-7. 2009..However, the potential risks due to exposure to ionizing radiation associated with CCTA have raised concerns...
- 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesElliott M Antman
J Am Coll Cardiol 51:210-47. 2008
- Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)D Woodrow Benson
Department of Pediatrics, Cincinnati Children s Hospital, Ohio, USA
J Clin Invest 112:1019-28. 2003..Our findings reveal a molecular basis for some forms of congenital SSS and define a recessive disorder of a human heart voltage-gated sodium channel...
- A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN projectFabio Marroni
Institute of Genetic Medicine, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Munich, Germany
Circ Cardiovasc Genet 2:322-8. 2009..We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations...
- SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndromeVincent Probst
INSERM, UMR915, Nantes, France
Circ Cardiovasc Genet 2:552-7. 2009..However, in familial studies, the relationship between SCN5A mutations and BrS remains poorly understood. The aim of this study was to investigate the association of SCN5A mutations and BrS in a group of large genotyped families...
- Low-dose, 128-slice, dual-source CT coronary angiography: accuracy and radiation dose of the high-pitch and the step-and-shoot modeHatem Alkadhi
University Hospital Zurich, Institute of Diagnostic Radiology, Raemistrasse 100, Zurich, Switzerland
Heart 96:933-8. 2010..To compare the diagnostic accuracy and radiation doses of two low-dose protocols for coronary artery imaging with second-generation, dual-source CT in comparison with catheter angiography (CA)...
- Risk of arrhythmias in myotonic dystrophy: trial design of the RAMYD studyAntonio Dello Russo
Institute of Cardiology, Department of Cardiovascular Medicine, Catholic University, L go A Gemelli 8, 00168 Rome, Italy
J Cardiovasc Med (Hagerstown) 10:51-8. 2009....
- An advanced detrending method with application to HRV analysisMika P Tarvainen
University of Kuopio, Department of Applied Physics, Finland
IEEE Trans Biomed Eng 49:172-5. 2002..The method is based on smoothness priors approach and operates like a time-varying finite-impulse response high-pass filter. The effect of the detrending on time- and frequency-domain analysis of HRV is studied...
- Arrhythmogenic right ventricular cardiomyopathyCristina Basso
University of Padua Medical School, Padua, Italy
Lancet 373:1289-300. 2009..Cascade genetic screening of family members of gene-positive probands allows the identification of asymptomatic carriers who would require lifelong follow-up due to the age-related penetrance...
- Genetic variation in SCN10A influences cardiac conductionJohn C Chambers
Department of Epidemiology and Public Health, Imperial College London, UK
Nat Genet 42:149-52. 2010..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
- Common variants in 22 loci are associated with QRS duration and cardiac ventricular conductionNona Sotoodehnia
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
Nat Genet 42:1068-76. 2010..These findings extend our current knowledge of ventricular depolarization and conduction...
- Outcome parameters for trials in atrial fibrillation: executive summaryPaulus Kirchhof
Department of Cardiology and Angiology, University Hospital Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
Eur Heart J 28:2803-17. 2007..In addition to a careful selection of a relevant primary outcome parameter, coverage of outcomes in all major domains of AF-related morbidity and mortality is desirable for any clinical trial in AF...
- Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gatingLars Husmann
Department of Medical Radiology and Cardiovascular Center, University Hospital Zurich, Raemistr 100, CH 8091 Zurich, Switzerland
Eur Heart J 29:191-7. 2008..To determine the feasibility of prospective electrocardiogram (ECG)-gating to achieve low-dose computed tomography coronary angiography (CTCA)...
- Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adultsErik B Schelbert
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
JAMA 308:890-6. 2012Unrecognized myocardial infarction (MI) is prognostically important. Electrocardiography (ECG) has limited sensitivity for detecting unrecognized MI (UMI).
- Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to agingToon A B van Veen
Heart Lung Center, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands
Circulation 112:1927-35. 2005..The SCN5A sodium channel is a major determinant for cardiac impulse propagation. We used epicardial mapping of the atria, ventricles, and septae to investigate conduction velocity (CV) in Scn5a heterozygous young and old mice...
- A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrateKoonlawee Nademanee
Pacific Rim Electrophysiology Research Institute, Inglewood, California 90301, USA
J Am Coll Cardiol 43:2044-53. 2004..We sought to test the hypothesis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be used as target sites for catheter ablation of AF...
- A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstillW Antoinette Groenewegen
Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands
Circ Res 92:14-22. 2003..We propose that, although the functional effect of each genetic change is relatively benign, the combined effect of genetic changes eventually progresses to total AS...
- Increased temporal dispersion of myocardial repolarization in myotonic dystrophy type 1: beyond the cardiac conduction systemDamiano Magrì
Cardiology Department, S Andrea Hospital, Sapienza University of Rome, Rome, Italy
Int J Cardiol 156:259-64. 2012..We also investigated the possible differences within DM1 patients by subdividing them according either to the presence of first degree atrioventricular block (1st AVB) or to the cytosine-thymine-guanine (CTG) repeat expansion size...
- Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trialMichael Bohm
Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
Lancet 376:886-94. 2010..We aimed to test our hypothesis by investigating the association between heart rate and events in this patient population...
- Wavelet transforms and the ECG: a reviewPaul S Addison
CardioDigital Ltd, Elvingston Science Centre, East Lothian, UK
Physiol Meas 26:R155-99. 2005..In this review, the emerging role of the wavelet transform in the interrogation of the ECG is discussed in detail, where both the continuous and the discrete transform are considered in turn...
- Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depressionWillem J Kop
Department of Medicine, Division of Cardiology, University of Maryland Medical Center, Baltimore, MD 21201, USA
Psychosom Med 72:626-35. 2010..To investigate prospectively whether autonomic nervous system (ANS) dysfunction and inflammation play a role in the increased cardiovascular disease (CVD)-related mortality risk associated with depression...
- ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesisDavid G Strauss
Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Circ Arrhythm Electrophysiol 1:327-36. 2008....
- STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry)Gilles Montalescot
Institut de Cardiologie and INSERM U856, Pitie Salpetriere University Hospital, AP HP, 47 Boulevard de l Hopital, Paris 75013, France
Eur Heart J 28:1409-17. 2007..The aim of this study was to describe the management and outcomes using 'real-world' data taking the new definition of acute myocardial infarction into account...
- Dispersion of repolarization and beta-thalassemia major: the prognostic role of QT and JT dispersion for identifying the high-risk patients for sudden deathVincenzo Russo
Chair of Cardiology, Second University of Naples, Naples, Italy
Eur J Haematol 86:324-31. 2011..The aim of our study was to evaluate the heterogeneity of ventricular repolarization in patients with beta-thalassemia and to test the hypothesis that an abnormal QTc and JTc dispersion may predict SCD in this population...
- Long-term follow-up of arrhythmias in patients with myotonic dystrophy treated by pacing: a multicenter diagnostic pacemaker studyArnaud Lazarus
Service de Cardiologie et de Biostatistique, Hopital Cochin, Paris, France
J Am Coll Cardiol 40:1645-52. 2002....
- Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular nodeMaria M Kreuzberg
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Romerstrasse 164, 53117 Bonn, Germany
Proc Natl Acad Sci U S A 103:5959-64. 2006..g., atrial fibrillation) by preventing rapid conduction to the ventricles potentially associated with hemodynamic deterioration...
- Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosisAnne Royer
INSERM U533, Institut du Thorax, Faculte de Medecine, Nantes, France
Circulation 111:1738-46. 2005..In the present study, we investigated heterozygous Scn5a-knockout mice (Scn5a+/- mice) as a model for hereditary Lenègre's disease...
- Defining left bundle branch block in the era of cardiac resynchronization therapyDavid G Strauss
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Cardiol 107:927-34. 2011..Further studies are needed to reinvestigate the electrocardiographic criteria for complete LBBB and the implications of these criteria for selecting patients for CRT...
- Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient micePaulus Kirchhof
Department of Cardiology and Angiology, Hospital of the University of Muenster, Germany
Circulation 114:1799-806. 2006..To test the hypothesis that reduced desmosomal protein expression causes ARVC, we studied the cardiac effects of heterozygous plakoglobin deficiency in mice...
- Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient miceVesna Nikolova
Molecular Cardiology Program, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
J Clin Invest 113:357-69. 2004..Despite severe DCM, defects in nuclear function prevent Lmna(-/-) cardiomyocytes from developing compensatory hypertrophy and accelerate disease progression...
- Drug-induced prolongation of the QT intervalDan M Roden
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
N Engl J Med 350:1013-22. 2004
- The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2Baofeng Yang
Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150086, China
Nat Med 13:486-91. 2007..1) and GJA1 (which encodes connexin 43), and this likely accounts at least in part for its arrhythmogenic potential. Thus, miR-1 may have important pathophysiological functions in the heart, and is a potential antiarrhythmic target...
- Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1William J Groh
Department of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis 46202, USA
N Engl J Med 358:2688-97. 2008..Sudden death can occur as a consequence of cardiac-conduction abnormalities in the neuromuscular disease myotonic dystrophy type 1. The determinants of the risk of sudden death remain imprecise...
- Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expressionSrijita Sen-Chowdhry
The Heart Hospital, University College London, United Kingdom
Circulation 115:1710-20. 2007..We hypothesized that unbiased representation of the spectrum of disease expression in arrhythmogenic right ventricular dysplasia/cardiomyopathy would require in vivo assessment of families in a genetically heterogeneous population...
- Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathyKalliopi Pilichou
Department of Medical Diagnostic Sciences and Special Therapies, University of Padua, 35121 Padua, Italy
J Exp Med 206:1787-802. 2009..Insight into mechanisms initiating myocardial damage in ARVC is a prerequisite to the future development of new therapies aimed at delaying onset or progression of the disease...
- Radiation dose reduction and coronary assessability of prospective electrocardiogram-gated computed tomography coronary angiography: comparison with retrospective electrocardiogram-gated helical scanTakao Maruyama
Department of Cardiology, Kawasaki Hospital, Kobe, Japan
J Am Coll Cardiol 52:1450-5. 2008....
- Prosthetic heart valve assessment with multidetector-row CT: imaging characteristics of 91 valves in 83 patientsJesse Habets
Department of Radiology, UMC Utrecht, P O Box 85500, E01 132, 3508, GA, Utrecht, The Netherlands
Eur Radiol 21:1390-6. 2011..Multidetector CT (MDCT) has shown potential for prosthetic heart valve (PHV) assessment. We assessed the image quality of different PHV types to determine which valves are suitable for MDCT evaluation...
- Mutational spectrum in the Ca(2+)--activated cation channel gene TRPM4 in patients with cardiac conductance disturbancesBirgit Stallmeyer
Institut für Genetik von Herzerkrankungen, Universitatsklinikum Munster, Munster, Germany
Hum Mutat 33:109-17. 2012..The phenotypes are variable and clearly suggestive of additional factors modulating the disease phenotype in some patients...
- Assessment of clinical features in transient left ventricular apical ballooningYoshiteru Abe
Division of Cardiology, Shimada Municipal Hospital, Shimada, Shizuoka, Japan
J Am Coll Cardiol 41:737-42. 2003..We sought to assess the clinical features of transient left ventricular (LV) apical ballooning...
- Dry and noncontact EEG sensors for mobile brain-computer interfacesYu Mike Chi
Department of Electrical and Computer Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA 92093, USA
IEEE Trans Neural Syst Rehabil Eng 20:228-35. 2012..The results of these experiments show that both dry and noncontact electrodes, with further development, may become a viable tool for both future mobile BCI and general EEG applications...
- Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT: technique and initial experienceMichael Lell
Diagnostic Radiology, University of Erlangen, Erlangen, Germany
Eur Radiol 19:2576-83. 2009..We evaluated radiation exposure and image quality of a new coronary CT angiography protocol, high-pitch spiral acquisition, using dual source CT (DSCT)...
- Mechanisms for discordant alternansM A Watanabe
Physics Department, Northeastern University, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 12:196-206. 2001..CONCLUSION: Spatial inhomogeneities of electrical restitution properties are not required to produce discordant alternans...
- Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitusP Rossing
Steno Diabetes Center, Gentofte, Denmark
Diabet Med 18:199-205. 2001..To evaluate prolonged QTc interval and QT dispersion as predictors of all-cause and cardiovascular mortality after adjustment for well-established risk factors in Type 1 diabetic patients...
- Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force CriteriaFrank I Marcus
University of Arizona, Tucson, AZ, USA
Eur Heart J 31:806-14. 2010..Consequently, the 1994 criteria were highly specific but lacked sensitivity for early and familial disease...
- Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmicL M Hondeghem
Department of Pharmacology, Leuven, Belgium
Circulation 103:2004-13. 2001..Prolongation of action potential duration (APD) is considered a major antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic (torsade de pointes)...
- Cardiac-resynchronization therapy for mild-to-moderate heart failureAnthony S L Tang
Island Medical Program, University of British Columbia, Vancouver, Canada
N Engl J Med 363:2385-95. 2010..Most of these patients are candidates for an implantable cardioverter-defibrillator (ICD). We evaluated whether adding CRT to an ICD and optimal medical therapy might reduce mortality and morbidity among such patients...
- Recommendations for interpretation of 12-lead electrocardiogram in the athleteDomenico Corrado
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Via Giustiniani 2, Padova, Italy
Eur Heart J 31:243-59. 2010..of an international panel of cardiologists and sports medical physicians with expertise in the fields of electrocardiography, imaging, inherited cardiovascular disease, cardiovascular pathology, and management of young competitive ..
- Technical and organisational feasibility of a multifunctional telemedicine system in an emergency medical service - an observational studySebastian Bergrath
Emergency Medical Care Section, Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
J Telemed Telecare 17:371-7. 2011..Use of the telemedical system in EMS is feasible and the quality of the transmitted images and video was satisfactory. However, technical reliability and availability need to be improved prior to routine use...
- Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndromeJohn R Giudicessi
Department of Medicine Division of Cardiovascular Diseases, Department of Pediatrics Division of Pediatric Cardiology, and Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota, USA
Heart Rhythm 8:1024-32. 2011..Given the prominent role of the transient outward current (I(to)) in BrS pathogenesis, we hypothesized that rare gain-of-function mutations in KCND3 may serve as a pathogenic substrate for BrS...
- Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT intervalHsien C Cheng
Safety Pharmacology, Drug Safety Evaluation, Sanofi Aventis, Bridgewater, NJ 08807, USA
J Pharmacol Toxicol Methods 54:278-87. 2006..Since QT intervals can be generated from paced or spontaneously beating hearts, data so generated can also be used for validating QT(c) correction equations...
- A prospective study on electrocardiographic findings of patients with organophosphorus poisoningSubash Vijayakumar
Department of Pharmacy Practice, Mahatma Gandhi Memorial Hospital, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India
Cardiovasc Toxicol 11:113-7. 2011..From this study, we conclude that acute organophosphorus poisoning is associated with ventricular arrhythmias, tachycardia and bradycardia, and attributes mild myocardial ischemia...
- Comparison of dual-source CT coronary angiography and conventional coronary angiography for detecting coronary artery diseaseYi Xu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China
Int J Cardiovasc Imaging 26:75-81. 2010..076). The diagnostic performance of DSCT-CCTA is generally as accurate as that of CAG. Thus, DSCT-CCTA is a reliable non-invasive method for detecting coronary artery stenosis...
- 107th ENMC international workshop: the management of cardiac involvement in muscular dystrophy and myotonic dystrophy. 7th-9th June 2002, Naarden, the NetherlandsK Bushby
Department of Neuromuscular Genetics, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
Neuromuscul Disord 13:166-72. 2003
- American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. A scientific statement from the AmericaJeffrey J Goldberger
J Am Coll Cardiol 52:1179-99. 2008
- Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imagingRaymond Y Kwong
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
Circulation 107:531-7. 2003..Managing chest pain in the emergency department remains a challenge with current diagnostic strategies. We hypothesized that cardiac MRI could accurately identify patients with possible or probable acute coronary syndrome...
- Fever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndromeAhmad S Amin
Heart Failure Research Center, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
J Clin Invest 118:2552-61. 2008....
- Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heartRie Schultz Hansen
Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
J Pharmacol Exp Ther 321:996-1002. 2007..Taken together, the present data strongly support the concept of using hERG activators as a treatment for certain kinds of arrhythmias and suggest further investigation of this new approach...
- Clinical implications of present physiological understanding of HRV componentsFederico Lombardi
Cardiologia, Dipartimento di Medicina Chirurgia e Odontoiatria, Osp San Paolo, University of Milan, Milan, Italy
Card Electrophysiol Rev 6:245-9. 2002....
- Functional recovery after acute myocardial infarction: comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injuryRobin Nijveldt
Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
J Am Coll Cardiol 52:181-9. 2008....
- Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac functionAxel Linke
Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
Proc Natl Acad Sci U S A 102:8966-71. 2005..These results suggest that strategies capable of activating the growth reserve of the myocardium may be important in cardiac repair after ischemic injury...
- Sensitive troponin I assay in early diagnosis of acute myocardial infarctionTill Keller
Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
N Engl J Med 361:868-77. 2009..Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction...
- Long QT syndromes and torsade de pointesS Viskin
Department of Cardiology, Sourasky Tel Aviv Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel
Lancet 354:1625-33. 1999..Mutations causing "silent" forms of congenital LQTS, in which the patient remains free of arrhythmias until exposed to drugs that further impair repolarisation, are now recognised...
- Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populationsW H Linda Kao
Department of Epidemiology, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
Circulation 119:940-51. 2009....
- Right ventricular function in patients with acute pulmonary embolism: analysis with electrocardiography-synchronized multi-detector row CTHalil Dogan
Department of Radiology, Leiden University Medical Center, Albinusdreef 2, C2 S, 2333 ZA Leiden, The Netherlands
Radiology 242:78-84. 2007To prospectively assess electrocardiography (ECG)-synchronized multi-detector row computed tomography (CT) for the evaluation of right ventricular (RV) function in patients suspected of having pulmonary embolism (PE).
- Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary diseaseHan W Kim
Duke Cardiovascular Magnetic Resonance Center, Division of Cardiology, Duke University, Durham, North Carolina, USA
PLoS Med 6:e1000057. 2009..However, the diagnosis of UMI is based on the appearance of incidental Q-waves on 12-lead electrocardiography. Thus, the syndrome of non-Q-wave UMI has not been investigated...
- High prevalence of early repolarization in short QT syndromeHiroshi Watanabe
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Heart Rhythm 7:647-52. 2010..It has been reported recently that early repolarization is associated with idiopathic ventricular fibrillation and the QT interval is short in patients with early repolarization...
- In vivo studies of Scn5a+/- mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalitiesClaire A Martin
Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom
J Electrocardiol 43:433-9. 2010....
- Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse modelClaire A Martin
Physiological Laboratory, Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK
Am J Physiol Heart Circ Physiol 300:H605-16. 2011..Our findings may contribute to future work investigating possible pharmacological treatments for a disease in which the current mainstay of treatment is implantable cardioverter defibrillator implantation...
- ST-segment elevation in conditions other than acute myocardial infarctionKyuhyun Wang
Hennepin County Medical Center, Cardiology Division, University of Minnesota, Minneapolis, MN 55415, USA
N Engl J Med 349:2128-35. 2003
- Multivariate short-term heart rate variability: a pre-diagnostic tool for screening heart diseaseAndreas Heitmann
Department of Medical Engineering and Biotechnology, University of Applied Sciences Jena, Jena, Germany
Med Biol Eng Comput 49:41-50. 2011..Multivariate short-term HRV, analyzed by both linear and nonlinear methods appears to be a suitable pre-diagnostic tool for screening heart disease in primary care settings...
- Assessment of interventricular and right-intraventricular dyssynchrony in patients with surgically repaired tetralogy of Fallot by two-dimensional speckle trackingMatthias Mueller
Department of Paediatric Cardiology, Saarland University Hospital, Kirrberger Strase, 66421 Homburg Saar, Germany
Eur J Echocardiogr 11:786-92. 2010..We aimed to assess interventricular and right-intraventricular dyssynchrony in patients after tetralogy of Fallot (TOF) repair by two-dimensional (2D) speckle tracking and to identify factors associated with dyssynchrony...
- Normal electrocardiography and serum troponin I levels preclude the presence of clinically significant blunt cardiac injuryGeorge C Velmahos
Department of Surgery, University of Southern California, and the Los Angeles County and University of Southern California LAC USC Medical Center, Los Angeles, CA 90033, USA
J Trauma 54:45-50; discussion 50-1. 2003..The purpose of this study was to examine whether the combination of two simple tests, electrocardiography (ECG) and serum troponin I (TnI) level, may serve as reliable predictors of BCI or the absence of it.
- Acute ECG ST-segment elevation mimicking myocardial infarction in a patient with pulmonary embolismTomaž Goslar
Clinical Department for Internal Intensive Care, University Medical Center Ljubljana, Slovenia
Cardiovasc Ultrasound 8:50. 2010....
- State-of-the-art CT imaging techniques for congenital heart diseaseHyun Woo Goo
Department of Radiology and the Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
Korean J Radiol 11:4-18. 2010....
- The relationship between high resting heart rate and ventricular arrhythmogenesis in patients referred to ambulatory 24 h electrocardiographic recordingElsayed Z Soliman
Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, NC 27104, USA
Europace 12:261-5. 2010..Ventricular arrhythmia is the most common antecedent event before SCD. Examining associations between resting HR and ventricular arrhythmogenesis may enhance our understanding of the association between high resting HR and SCD...
- A patient-adapting heartbeat classifier using ECG morphology and heartbeat interval featuresPhilip de Chazal
BiancaMed Ltd, NovaUCD, Belfield Innovation Park, University College Dublin, Belfield Dublin 4, Ireland
IEEE Trans Biomed Eng 53:2535-43. 2006..This study illustrates the ability to provide highly beneficial automatic arrhythmia monitoring and is an improvement on previously reported results for automated heartbeat classification systems...
- Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam StudyAnneke De Torbal
Department of Epidemiology and Biostatistics, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Eur Heart J 27:729-36. 2006..Contemporary data on the incidence of unrecognized myocardial infarction (MI) among subjects aged 55 and older are limited...
- Aging and nonlinear heart rate control in a healthy populationFrank Beckers
Laboratory of Experimental Cardiology, School of Medicine, Katholieke Universiteit Leuven, UZ Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
Am J Physiol Heart Circ Physiol 290:H2560-70. 2006..No clear difference between men and women was found in the nonlinear indexes. Nonlinear indexes decline with age. This can be related to the concept of decreasing autonomic modulation with advancing age...
- Cardiac resynchronization with sequential biventricular pacing for the treatment of moderate-to-severe heart failureAngel R Leon
Carlyle Fraser Heart Center Division of Cardiology, Emory University, Atlanta, Georgia, USA
J Am Coll Cardiol 46:2298-304. 2005..The InSync III study evaluated sequential cardiac resynchronization therapy (CRT) in patients with moderate-to-severe heart failure and prolonged QRS...
- Reviewing myocardial silent ischemia: specific patient subgroupsTheodoros Xanthos
Department of Experimental Surgery and Surgical Research N S Christeas, Athens School of Medicine, Athens, Greece
Int J Cardiol 124:139-48. 2008....
- Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteersR Ammar
University of Connecticut School of Pharmacy, Storrs, USA
Pharmacotherapy 21:437-42. 2001....
- QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-upC Stettler
Division of Endocrinology and Diabetes, University of Bern, Inselspital, CH 3010, Bern, Switzerland
Diabetologia 50:186-94. 2007..We evaluated the association of QT interval corrected for heart rate (QT(c)) and resting heart rate (rHR) with mortality (all-causes, cardiovascular, cardiac, and ischaemic heart disease) in subjects with type 1 and type 2 diabetes...
- Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after subacute ST-segment elevation myocardial infarction undergoing late revascularization: final results from the G-CSF-STEMI (Granulocyte Colony-Stimulating Markus G Engelmann
Medical Clinic I Department of Cardiology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
J Am Coll Cardiol 48:1712-21. 2006....
- Value of acute rest sestamibi perfusion imaging for evaluation of patients admitted to the emergency department with chest painM C Kontos
Medical College of Virginia Virginia Commonwealth University, Richmond 23298 0128, USA
J Am Coll Cardiol 30:976-82. 1997....
- QT dispersion: comparison between diabetic and non-diabetic individuals and correlation with cardiac autonomic neuropathyMichael Psallas
First Department of Propaedeutic Medicine, Athens University, Laiko Hospital, Athens, Greece
Hellenic J Cardiol 47:255-62. 2006..The aim of this study was to investigate: 1) the differences in QTd between diabetics and non-diabetics; 2) the differences in QTd between those with type 1 and type 2 diabetes; 3) the relation between QTd and CAN...
- Calculation of effective VV interval facilitates optimization of AV delay and VV interval in cardiac resynchronization therapyKevin Vernooy
Department of Physiology, Maastricht University, Maastricht, The Netherlands
Heart Rhythm 4:75-82. 2007..The optimal combination of AV delay and VV interval currently is determined by extensive hemodynamic testing...
- A prospective comparison of AV delay programming methods for hemodynamic optimization during cardiac resynchronization therapyMichael R Gold
Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Cardiovasc Electrophysiol 18:490-6. 2007..The present study was designed to compare the acute effects of AVD programming methods during CRT...
- Q-wave prediction of myocardial infarct location, size and transmural extent at magnetic resonance imagingDaniele Rovai
CNR, Clinical Physiology, Italy
Coron Artery Dis 18:381-9. 2007..We investigated how pathologic Q waves or equivalents predict location, size and transmural extent of myocardial infarction (MI)...
- P-wave durations in patients experiencing atrial fibrillation during exercise testingOzcan Ozdemir
Turkiye Yuksek Ihtisas Hospital, Cardiology Clinics, Ankara, Turkey
Angiology 58:97-101. 2007..Furthermore, treatment of these patients with beta blockers would appear to decrease the recurrence of exercise-induced AF and to be associated with a decrease in P-wave durations...
- Diagnosis of paroxysmal atrial fibrillation in patients with implanted pacemakers: relationship to symptoms and other variablesGianluca Quirino
Ivrea Hospital, Ivrea, Italy
Pacing Clin Electrophysiol 32:91-8. 2009..The study prospectively evaluated the burden of asymptomatic AF episodes in pacemaker patients (for sick sinus syndrome) with a history of documented paroxysmal AF...
- Update and modification of Task Force Criteria for ARVD/CFrank Marcus; Fiscal Year: 2007..several members from the original Task Force on ARVD/C, and current experts in the imaging modalities, electrocardiography and pathology who have a major interest in ARVD/C...
- Autonomic consequences of brief seizuresMark Stewart; Fiscal Year: 2004..abstract_text> ..
- PROMISE Trial: EQOL Coordinating CenterDaniel B Mark; Fiscal Year: 2010..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
- PROMISE Trial: SDCCKerry L Lee; Fiscal Year: 2010..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
- PROMISE Trial: Dx CoreUdo Hoffmann; Fiscal Year: 2010..testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
- PROMISE Trial: Dx CoreUdo Hoffmann; Fiscal Year: 2009..stress testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
- PROMISE Trial: Clinical Coordinating CenterPamela Susan Douglas; Fiscal Year: 2010
- PROMISE Trial: SDCCKerry Lee; Fiscal Year: 2009..stress testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
- PROMISE Trial: Clinical Coordinating CenterPamela Douglas; Fiscal Year: 2009..stress testing strategy (using physician-selected stress imaging (echocardiography or nuclear) or exercise electrocardiography)) in low-intermediate coronary artery risk patients with chest pain, and will reduce the composite primary ..
- PROMISE Trial: EQOL Coordinating CenterDaniel Mark; Fiscal Year: 2009
- AUTONOMIC FUNCTION AND POSTTRANSPLANT QUALITY OF LIFEDonna Hathaway; Fiscal Year: 1999....
- Bupropion VS Placebo to Treat Pathological GamblingDonald Black; Fiscal Year: 2004..abstract_text> ..
- Point Process Models of Human Heart Beat Interval DynamicsRiccardo Barbieri; Fiscal Year: 2010..The health implications of this project are a more accurate characterization of cardiovascular control in research and clinical studies of both normal and pathological conditions. ..
- Point Process Models of Human Heart Beat Interval DynamicsRiccardo Barbieri; Fiscal Year: 2007..The health implications of this project are a more accurate characterization of cardiovascular control in research and clinical studies of both normal and pathological conditions. ..
- Movement-Responsive Cage for Simultaneous Pharmacology Studies in MiniPigsDouglas Mann; Fiscal Year: 2007..programmed dosing, and physiological data acquisition modules for core body temperature, blood pressure and electrocardiography. In accordance with the intent of the SBIR program, the ultimate objective is an instrument that can be ..
- Exercise Stress Cardiovascular Magnetic ResonanceORLANDO PAUL contact SIMONETTI; Fiscal Year: 2010..affords for the first time measurement of myocardial perfusion, diastolic function, systolic function, electrocardiography, myocardial edema and exertional symptoms - the complete ischemic cascade - in one test...
- Subcellular Origin of T-wave Alternans in the Beating Mouse HeartAriel L Escobar; Fiscal Year: 2010..The resulting transmural difference in AP repolarization creates the TW-Alt observed in the ECG waveform. ..
- Subcellular Origin of T-wave Alternans in the Beating Mouse HeartARIEL ESCOBAR; Fiscal Year: 2007..The resulting transmural difference in AP repolarization creates the TW-Alt observed in the ECG waveform. ..
- Novel Pharmacological Strategies in AutismChristopher McDougle; Fiscal Year: 2009..Phase II (following 6 months of aripiprazole monotherapy). ..