liver function tests

Summary

Top Publications

  1. ncbi Histological changes in the liver of morbidly obese patients: correlation with metabolic parameters
    Anna Maria Wolf
    Department of Visceral and Transplantation Surgery, University Hospital Ulm, Germany
    Obes Surg 15:228-37. 2005
  2. pmc Evaluation of abnormal liver function tests
    J K Limdi
    Tameside General Hospital, Ashton under Lyne, Manchester, UK
    Postgrad Med J 79:307-12. 2003
  3. ncbi AGA technical review on the evaluation of liver chemistry tests
    Richard M Green
    Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 123:1367-84. 2002
  4. ncbi 13C-breath tests: current state of the art and future directions
    B Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Dig Liver Dis 39:795-805. 2007
  5. ncbi The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients
    Sherene Shalhub
    Department of Surgery and Interdisciplinary Obesity Study Group, University of South Florida Health Sciences Center, Tampa, FL 33601, USA
    Obes Surg 14:54-9. 2004
  6. ncbi Evidence-based incorporation of serum sodium concentration into MELD
    Scott W Biggins
    University of California San Francisco, San Francisco, California, USA
    Gastroenterology 130:1652-60. 2006
  7. ncbi Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats
    Gene T Yocum
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Radiology 235:547-52. 2005
  8. pmc Liver enzyme alteration: a guide for clinicians
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    CMAJ 172:367-79. 2005
  9. ncbi Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
  10. ncbi Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town
    Gaspare Maria Pendino
    Divisione di Medicina 1, Policlinico Madonna della Consolazione, Reggio Calabria, Italy
    Hepatology 41:1151-9. 2005

Research Grants

  1. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2009
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2010
  3. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2007
  4. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2012
  5. TREATMENT OF ALCOHOLIC FIBROSIS WITH PHOSPHATIDYLCHOLINE
    Charles Lieber; Fiscal Year: 1993
  6. ANTIRETROVIRAL ACTIVITY OF HYDROXYUREA ALONE AND IN COMBINATION WITH DDI
    Carol Dukes Hamilton; Fiscal Year: 1999
  7. ANTIRETROVIRAL ACTIVITY OF HYDROXYUREA ALONE AND IN COMBINATION WITH DDI
    Carol Dukes Hamilton; Fiscal Year: 2001
  8. STUDIES IN PORPHYRIA CUTANEA TARDA
    Karl Anderson; Fiscal Year: 2000
  9. STUDIES IN PORPHYRIA CUTANEA TARDA
    Karl Anderson; Fiscal Year: 2001
  10. STUDIES IN PORPHYRIA CUTANEA TARDA
    Karl Anderson; Fiscal Year: 2002

Detail Information

Publications293 found, 100 shown here

  1. ncbi Histological changes in the liver of morbidly obese patients: correlation with metabolic parameters
    Anna Maria Wolf
    Department of Visceral and Transplantation Surgery, University Hospital Ulm, Germany
    Obes Surg 15:228-37. 2005
    ....
  2. pmc Evaluation of abnormal liver function tests
    J K Limdi
    Tameside General Hospital, Ashton under Lyne, Manchester, UK
    Postgrad Med J 79:307-12. 2003
    Interpretation of abnormalities in liver function tests is a common problem faced by clinicians. This has become more common with the introduction of automated routine laboratory testing...
  3. ncbi AGA technical review on the evaluation of liver chemistry tests
    Richard M Green
    Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 123:1367-84. 2002
  4. ncbi 13C-breath tests: current state of the art and future directions
    B Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Dig Liver Dis 39:795-805. 2007
    ..The stable isotope technique presents an elegant, non-invasive diagnostic tool promising further options of clinical applications. This review is aimed at providing an overview on the relevant clinical applications of 13C-breath tests...
  5. ncbi The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients
    Sherene Shalhub
    Department of Surgery and Interdisciplinary Obesity Study Group, University of South Florida Health Sciences Center, Tampa, FL 33601, USA
    Obes Surg 14:54-9. 2004
    ..Prevalence of NASH in bariatric patients is unknown. Our aim was to determine the role of routine liver biopsy in managing bariatric patients...
  6. ncbi Evidence-based incorporation of serum sodium concentration into MELD
    Scott W Biggins
    University of California San Francisco, San Francisco, California, USA
    Gastroenterology 130:1652-60. 2006
    ..Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation...
  7. ncbi Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats
    Gene T Yocum
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Radiology 235:547-52. 2005
    ....
  8. pmc Liver enzyme alteration: a guide for clinicians
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    CMAJ 172:367-79. 2005
    ....
  9. ncbi Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
    ..We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk...
  10. ncbi Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town
    Gaspare Maria Pendino
    Divisione di Medicina 1, Policlinico Madonna della Consolazione, Reggio Calabria, Italy
    Hepatology 41:1151-9. 2005
    ....
  11. ncbi Predicting liver failure following major hepatectomy
    G Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia
    Dig Liver Dis 41:798-806. 2009
    ..Published data would not suggest any difference in mortality, morbidity or liver failure rates between these groups. This review outlines and presents the evidence for pre-operative quantification of functional liver remnant volume...
  12. ncbi Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients
    Chung Bao Hsieh
    Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China
    World J Gastroenterol 10:2394-6. 2004
    ..To investigate whether the non-invasive real-time Indocyanine green (ICG) clearance is a sensitive index of liver viability in patients before, during, and after liver transplantation...
  13. doi Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Am J Gastroenterol 103:1136-44. 2008
    ..We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV)...
  14. pmc Epidemiology and genetic epidemiology of the liver function test proteins
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 4:e4435. 2009
    ..The liver function test (LFT) is among the most commonly used clinical investigations to assess hepatic function, severity of liver diseases and the effect of therapies, as well as to detect drug-induced liver injury (DILI)...
  15. doi Prognostic value of indocyanine green elimination assessed with LiMON in septic patients
    Mehmet Turan Inal
    Department of Anesthesiology, Trakya University Medical Faculty, 22030 Edirne, Turkey
    J Crit Care 24:329-34. 2009
    ..Sepsis is the most frequent infection with high mortality rates in intensive care units (ICUs), and the prediction of outcome is important in the decision-making process...
  16. doi Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    Cecilia Söderberg
    Department of Medicine, Karolinska Institute, Solna, Stockholm, Sweden
    Hepatology 51:595-602. 2010
    ..69; 95% confidence interval [CI], 1.24-2.25); subjects with bland steatosis, a 55% increase (SMR, 1.55; 95% CI, 0.98-2.32; P = 0.062); and subjects with NASH, 86% (SMR, 1.86; 95% CI, 1.19-2.76; P = 0.007)...
  17. doi Acoustic radiation force impulse elastography for chronic liver disease: comparison with ultrasound-based scores of experienced radiologists, Child-Pugh scores and liver function tests
    Ji Eun Kim
    Department of Radiology, Seoul National University Hospital, Seoul, Korea
    Ultrasound Med Biol 36:1637-43. 2010
    ..performance for diagnosis of chronic liver disease and correlates better with Child-Pugh scores and liver function tests, compared with an ultrasound (US) scoring system based on visual assessment of conventional B-mode US ..
  18. pmc Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh
    Khairul Islam
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh
    Environ Health 10:64. 2011
    ..However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented...
  19. pmc Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
    Winston Dunn
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Gastroenterol 103:2263-71. 2008
    ..The current study compared the survival of subjects with and without suspected NAFLD in a population-based cohort, and placed the finding in the context of previously published case series...
  20. ncbi Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study
    Philippe Halfon
    Department of Virology, Alphabio Laboratory, 23 Street of Friedland, 13006 Marseille, France
    Am J Gastroenterol 101:547-55. 2006
    ..The aim of this study was to perform an external validation of FT and AT and to study the discordances between FT/AT and liver biopsy in patients with chronic hepatitis C...
  21. ncbi Postoperative changes in liver function tests: randomized comparison of low- and high-pressure laparoscopic cholecystectomy
    S Hasukic
    Department of Surgery, University Clinical Center Tuzla, Faculty of Medicine, University of Tuzla, Trnovac b b, 75, 000, Tuzla, Bosnia Herzegovina
    Surg Endosc 19:1451-5. 2005
    ..This study evaluated the changes in liver function tests after high-pressure LC (HPLC; 14 mmHg) and low-pressure LC (LPLC; 7 mmHg).
  22. ncbi Liver function tests and their interpretation
    B R Thapa
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pediatr 74:663-71. 2007
    b>Liver function tests (LFT) are a helpful screening tool, which are an effective modality to detect hepatic dysfunction...
  23. ncbi Review article: the assessment of liver function using breath tests
    Y Ilan
    Liver Unit, Department of Medicine, Hebrew University, Hadassah Medical Center, Jerusalem, Israel
    Aliment Pharmacol Ther 26:1293-302. 2007
    ..The recent development of a real-time, point-of-care liver function breath test has made it straightforward to assess the metabolic function of the liver...
  24. ncbi Prevalence of hepatitis B and C seromarkers and abnormal liver function tests among hemophiliacs in Guilan (northern province of Iran)
    Fariborz Mansour-Ghanaei
    Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
    Med Sci Monit 8:CR797-800. 2002
    The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnormal liver function tests among hemophiliacs in Guilan province, Iran.
  25. ncbi Adiponectin, hepatocellular dysfunction and insulin sensitivity
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 60:256-63. 2004
    ....
  26. ncbi Autoimmune hepatitis
    Edward L Krawitt
    Department of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
    N Engl J Med 354:54-66. 2006
  27. ncbi Pretreatment of male BALB/c mice with beta-ionone potentiates thioacetamide-induced hepatotoxicity
    T C Jeong
    Toxicology Research Center, Korea Research Institute of Chemical Technology, Taejon, South Korea
    Toxicol Lett 105:39-46. 1999
    ..our present results suggest that beta-ionone may be a useful model inducer of P450 enzyme(s) in studying toxic mechanism of certain chemicals which require metabolic activation by P450s in mice...
  28. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
    ..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
  29. ncbi Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral therapy
    E Martinez
    Unit of Infectious Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, Barcelona, Spain
    AIDS 15:1261-8. 2001
    ..To assess the incidence and risk factors for hepatotoxicity associated with nevirapine...
  30. pmc The association of alanine transaminase with aging, frailty, and mortality
    David G Le Couteur
    Centre for Education and Research on Ageing, Concord RG Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia
    J Gerontol A Biol Sci Med Sci 65:712-7. 2010
    ..Low ALT activity is a predictor of reduced survival; however, this seems to be mediated by its association with frailty and increasing age. ALT has potential value as a novel biomarker of aging...
  31. ncbi Brief communication: clinical implications of short-term variability in liver function test results
    Mariana Lazo
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 148:348-52. 2008
    ..Clinicians sometimes order liver tests as part of a screening examination or general work-up. Current guidelines do not recommend routine retesting of abnormal results in asymptomatic patients...
  32. ncbi Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities
    Michael D McGoon
    Mayo Clinic, Rochester, MN 55905, USA
    Chest 135:122-9. 2009
    ..Because ambrisentan may provide benefits in PAH patients who have discontinued ERA therapy due to LFT abnormalities, we evaluated the safety and efficacy of ambrisentan in this patient population...
  33. ncbi Evaluation of ornithine carbamoyl transferase and other serum and liver-derived analytes in diagnosis of fatty liver and postsurgical outcome of left-displaced abomasum in dairy cows
    Emmanouil Kalaitzakis
    Clinic of Farm Animals, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
    J Am Vet Med Assoc 229:1463-71. 2006
    ....
  34. doi Nuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation
    Wilmar de Graaf
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Nucl Med 51:742-52. 2010
    ..In liver transplantation, these methods are used to assess graft function and biliary complications...
  35. pmc Muscular exercise can cause highly pathological liver function tests in healthy men
    Jonas Pettersson
    AstraZeneca R and D Lund, Lund, Sweden
    Br J Clin Pharmacol 65:253-9. 2008
    ..Physical exercise can result in transient elevations of liver function tests. There is no consensus in the literature on which forms of exercise may cause changes in liver function ..
  36. ncbi Living liver donor death related to complications of myeloma
    Emmanuel Melloul
    Department of HPB Surgery and Liver Transplantation, Hospital Beaujon, Clichy, France
    Liver Transpl 15:326-9. 2009
    ..This unusual cause of donor death after right hepatectomy reinforces the need for an extensive preoperative assessment. We advocate the addition of urinary protein loss and electrophoresis to the standard donor assessment protocol...
  37. ncbi Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:283-7. 2008
    When the liver function tests are aggravated after starting antithyroid drugs (ATDs) in Graves' hyperthyroidism, discontinuation of ATDs is generally considered...
  38. ncbi Liver function tests: their role in the diagnosis of hepatobiliary diseases
    Joseph A Knight
    Division of Education at the Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Infus Nurs 28:108-17. 2005
    ..Although liver function tests are critical in recognizing the presence of liver disease and its specific diagnosis, the interpretation of ..
  39. doi Hepatotoxic effects of therapies for tuberculosis
    Bahaa E Senousy
    Internal Medicine Department, Ain Shams University, Abbassia 11566, Cairo, Egypt
    Nat Rev Gastroenterol Hepatol 7:543-56. 2010
    ....
  40. pmc Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows
    Felix Diaz González
    Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Vet Sci 12:251-5. 2011
    ..During early lactation, 30% of cows suffered hepatic lipidosis as detected by levels of AST. Compromised hepatic function was observed in early lactation cows as shown by lower concentrations of glucose, total protein, and urea...
  41. ncbi Simple clinical variables predict liver histology in hepatitis C: prospective validation of a clinical prediction model
    Joseph Romagnuolo
    Digestive Disease Center, University of South Carolina, 96 Jonathon Lucas Street, PO Box 250 327, Charleston, SC 29425, USA
    Scand J Gastroenterol 40:1365-71. 2005
    ..Absence of predictors also predicted a lack of inflammation and fibrosis. Our aim was prospectively to validate this clinical prediction model using an independent multicenter sample...
  42. doi Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure
    N De Liguori Carino
    Supra Regional Hepatobiliary Unit, University Hospital Aintree, Liverpool, L9 7AL, UK
    Eur J Surg Oncol 35:957-62. 2009
    ..The aim was to assess the relationship between pre and post-operative ICG plasma disappearance rate (ICG PDR %/min) values and the onset of post-hepatectomy liver dysfunction...
  43. doi Background incidence of liver chemistry abnormalities in a clinical trial population without underlying liver disease
    John G Weil
    WW Epidemiology, Neurosciences and International Support, GlaxoSmithKline Research and Development Ltd, New Frontiers Science Park, South Third Avenue, Harlow, Essex CM19 5AW, UK
    Regul Toxicol Pharmacol 52:85-8. 2008
    ..The study was undertaken to determine the background rates of liver chemistry abnormalities in clinical trial populations without underlying liver disease...
  44. ncbi Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 53:2623-32. 2004
    ..In conclusion, AST and ALT independently predict type 2 diabetes. Baseline elevations of these markers may reflect NAFLD or related pathologies...
  45. ncbi Perioperative outcome after laparoscopic radiofrequency ablation of liver tumors: an analysis of 521 cases
    E Berber
    Department of General Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Surg Endosc 21:613-8. 2007
    ..Understanding the morbidity and laboratory changes after RFA is important for operative indications and perioperative management...
  46. ncbi Noninvasive quantitative testing of liver function using ultrasonography in patients with cirrhosis
    Guo Zhen Yan
    Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    Hepatogastroenterology 53:15-20. 2006
    ....
  47. doi A novel cause for abnormal liver function tests in pregnancy and the puerperium: non-alcoholic fatty liver disease
    L M Page
    Department of Obstetrics and Gynaecology, West Middlesex University Hospital, Isleworth, UK
    BJOG 118:1532-5. 2011
    ..We suggest that NAFLD should also be considered as a cause for abnormal liver function tests during pregnancy...
  48. doi Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers
    Mireen Friedrich-Rust
    Department of Internal Medicine, JW Goethe University Clinic, Frankfurt, Germany
    J Thorac Cardiovasc Surg 135:560-7. 2008
    ..Therefore, early detection of fibrosis is essential to identify patients at risk. Transient elastography has been evaluated for noninvasive staging of liver fibrosis in a multitude of studies...
  49. doi Liver function tests and statins
    Philippe J Zamor
    Department of Medicine, Center for Liver Diseases and Transplantation, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Curr Opin Cardiol 26:338-41. 2011
    ..To discuss recent data on statins in patients with elevated liver tests...
  50. ncbi Hepatitis G virus RNA is common in AIDS patients' plasma but is not associated with abnormal liver function tests or other clinical syndromes
    I Woolley
    Division of Infectious Diseases, University Hospitals of Cleveland, Center for AIDS Research, Case Western Reserve University, Ohio 44106 5083, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 19:408-12. 1998
    ..7; 95% confidence interval [CI], 2.4-25.0) but hepatitis C antibody was not. Mean values for liver function tests and hematologic values did not differ significantly between the groups nor did the occurrence of certain ..
  51. pmc Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE)
    Peter T Donnan
    Tayside Centre for General Practice, Community Health Sciences, University of Dundee, Dundee, UK
    BMC Health Serv Res 7:54. 2007
    b>Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations...
  52. doi A case of elevated liver function tests after crown-of-thorns (Acanthaster planci) envenomation
    Brian Lin
    Stanford University Medical Center, Palo Alto, CA, USA
    Wilderness Environ Med 19:275-9. 2008
    ..We describe elevated liver enzymes in a 19-year-old female associated with A planci spine puncture wounds. To our knowledge, this is the first documented report of transaminitis in a human after A planci envenomation...
  53. doi Association between serum prostate-specific antigen level, liver function tests and lipid profile in healthy men
    June Hyun Han
    Department of Urology, Hanil General Hospital, KEPCA Medical Foundation, Seoul, Korea
    BJU Int 102:1097-101. 2008
    To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-..
  54. ncbi Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 6:231-47. 2003
    ..administration of different concentrations of honey and their effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride (CCl(4))-induced liver damage were studied...
  55. ncbi Serum phenylalanine concentration as a marker of liver function in obese patients before and after bariatric surgery
    Julian Swierczynski
    Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80 241, Gdansk, Poland
    Obes Surg 19:883-9. 2009
    ..This study examines whether improvements of liver function after bariatric surgery is associated with a decrease of serum phenylalanine concentration caused by an increase of phenylalanine metabolism...
  56. pmc The prognostic role of WHO classification, urinary 5-hydroxyindoleacetic acid and liver function tests in metastatic neuroendocrine carcinomas of the gastroenteropancreatic tract
    V Formica
    Department of Medicine, Royal Marsden Hospital, London and Sutton, Surrey, UK
    Br J Cancer 96:1178-82. 2007
    ..In a WDNEC-restricted analysis, abnormal liver function tests (LFTs) and elevated urinary 5-hydroxyindoleacetic acid (u5HIAA) were independent prognostic factors for ..
  57. pmc Liver function tests: defining what's normal
    Paul Roderick
    Community Clinical Sciences Research Division, University of Southampton, B Floor, South Academic Block, Southampton General Hospital, Southampton SO16 6YD
    BMJ 328:987. 2004
  58. ncbi Use of middle hepatic vein in right lobe living donor liver transplantation
    Murat Dayangac
    Florence Nightingale Hospital, Center for Organ Transplantation, Abide i Hurriyet Caddesi No 290 Sisli, Istanbul, Turkey
    Transpl Int 23:285-91. 2010
    ..The decision, therefore, of the extent of right lobe donor hepatectomy should be tailored to the particular conditions considering the graft quality and metabolic demand of the recipient...
  59. doi Long-term cyclosporine treatment: evaluation of serum biochemical parameters and histopathological alterations in Wistar rats
    Ana Elisa Böhmer
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    Exp Toxicol Pathol 63:119-23. 2011
    ..These results suggest that the CsA concentrations administered in our experimental protocol were able to induce immunosuppression in rats without causing nephro and hepatotoxicity...
  60. ncbi Liver function tests in metastatic uveal melanoma
    Igor Kaiserman
    Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel
    Am J Ophthalmol 137:236-43. 2004
    To evaluate trends in liver function tests before detection of liver metastases from uveal melanoma.
  61. ncbi Comparison of postoperative hepatic function after laparoscopic versus open gastric bypass
    Ninh T Nguyen
    Department of Surgery, Medical Center, University of California Davis, Sacramento, CA, USA
    Am J Surg 186:40-4. 2003
    ..Pneumoperitoneum has been shown to reduce hepatic portal blood flow and alter postoperative hepatic transaminases. This study evaluated the changes in hepatic function after laparoscopic and open gastric bypass (GBP)...
  62. ncbi [Clinical characteristics of factory workers with asymptomatic liver function test abnormalities found on serial health examination]
    Kang Mo Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Korean J Hepatol 11:144-56. 2005
    The liver function tests (LFTs), such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltranspeptidase (gamma-GT), have been widely used as screening tests but their low positive predictive value can ..
  63. ncbi Assessment of hepatic reserve for the indication of hepatic resection: how I do it
    Gian Massimo Gazzaniga
    Department of Surgery, HPB Unit, Galliera Hospital Genova, Via A Volta 1, 16100 Genoa, Italy
    J Hepatobiliary Pancreat Surg 12:27-30. 2005
    ..However, a good multifactorial system that combines several elements (clinical, laboratory, functional, and volumetric evaluation) does provide sufficient data for determining the safe limits of hepatectomy...
  64. ncbi Abnormal liver function tests following bone marrow transplantation: aetiology and role of liver biopsy
    Gwo Tzer Ho
    Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK
    Eur J Gastroenterol Hepatol 16:157-62. 2004
    ..We studied the prevalence and aetiology of abnormal liver function tests following bone marrow transplantation and the role of liver biopsy.
  65. ncbi [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity]
    Sonia Chavarría-Arciniega
    Clínica de Obesidad del Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
    Rev Invest Clin 57:505-12. 2005
    ..Hepatic biochemical test are abnormal. Despite the lack of its own morphological characteristics, NASH can be differentiated from other pathologies, the gold standard for diagnosis is liver biopsy...
  66. ncbi Liver damage in obese patients
    Antonio Del Gaudio
    Department of Surgery, University of Bologna, S Orsola Hospital, Via Massarenti, 9, I 40138 Bologna, Italy
    Obes Surg 12:802-4. 2002
    ..The aim of this study is to determine the hepatic conditions of morbidly obese patients during bariatric surgery by means of a wedge liver biopsy, to avoid any eventual hepatic damage being ascribed to the surgical procedure...
  67. pmc Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI
    Henrik Nilsson
    Department of Clinical Sciences, Karolinska Institutet, Stockholm, Sweden
    HPB (Oxford) 12:567-76. 2010
    ..The aim of this study was to determine whether the hepatic uptake and excretion of Gd-EOB-DTPA differ between patients with primary biliary cirrhosis (PBC) and healthy controls, and whether differences could be quantified...
  68. doi Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI
    Henrik Nilsson
    Karolinska Institutet, Sweden
    J Magn Reson Imaging 29:1323-31. 2009
    ..To assess the feasibility to use dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) as an imaging-based liver function test, and to compare two methods for deconvolutional analysis (DA) in healthy human subjects...
  69. doi Health outcomes following liver function testing in primary care: a retrospective cohort study
    David J McLernon
    Medical Statistics Team, Section of Population Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
    Fam Pract 26:251-9. 2009
    patients who present with abnormal liver function tests (LFTs) in primary care and no obvious symptoms can be difficult to manage.
  70. ncbi Occupational lead exposure and amino acid profiles and liver function tests in industrial workers
    F R Al Neamy
    Department of Biochemistry, Al Ain Hospital, Ministry of Health, Al Ain, United Arab Emirates
    Int J Environ Health Res 11:181-8. 2001
    ..These results might be related to lead exposure and might have affects on the kidneys or liver...
  71. doi Quantitative assessment of hepatic function and its relevance to the liver surgeon
    G Morris-Stiff
    Department of Hepatobiliary and Transplant Surgery, St James s Hospital, Leeds, UK
    J Gastrointest Surg 13:374-85. 2009
    ....
  72. ncbi Liver enzyme alterations after laparoscopic cholecystectomy
    H Erhan Guven
    3rd General Surgery Department, Ankara Oncology Research and Training Hospital, Demetevler Ankara, Turkey, 91 6 06500 Y Bahçelievler, Ankara, Turkey
    J Gastrointestin Liver Dis 16:391-4. 2007
    ....
  73. doi A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients
    Guilherme M Campos
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 0790, USA
    Hepatology 47:1916-23. 2008
    ..3; 95% CI, 1.4-8.0), and non-Black race (OR, 8.4; 95% CI, 1.9-37.1). A NASH Clinical Scoring System for Morbid Obesity was derived to predict the probability of NASH in four categories (low, intermediate, high, and very high)...
  74. ncbi Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii
    Amy C Brown
    Department of Complementary and Alternative Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Clin Toxicol (Phila) 45:549-56. 2007
    To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu).
  75. ncbi Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients
    Chien Wei Su
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Gastroenterology 130:1625-35. 2006
    ..Genotypes and viremia of hepatitis D virus (HDV) and hepatitis B virus (HBV) may be associated with outcomes. This study evaluated the impact of viral genotypes and viremia on outcomes of dual HBV and HDV infection...
  76. ncbi Transient liver dysfunction after laparoscopic gastrectomy for gastric cancer patients
    Tsuyoshi Etoh
    Department of Surgery I, Oita University Faculty of Medicine, 1 1 Hasama machi, Oita, 879 5593, Japan
    World J Surg 31:1115-20. 2007
    ..The aim of this study was to clarify whether laparoscopy-assisted distal gastrectomy (LADG) is associated with changes in liver function compared with open distal gastrectomy (ODG)...
  77. ncbi Motion - all patients with NASH need to have a liver biopsy: arguments for the motion
    Jayant A Talwalkar
    Mayo Clinic and Foundation, Rochester 55902, USA
    Can J Gastroenterol 16:718-21. 2002
    ..Only histological examination can establish the diagnosis of NASH, grade its severity, determine the prognosis and guide treatment...
  78. ncbi Measurement of liver function for patients with cirrhosis by 13C-methacetin breath test compared with Child-Pugh score and routine liver function tests
    Yun Xiang Liu
    Department of Gastroenterology, Yantai Yuhuangding Hospital, Affiliated to Medical College of Qingdao University, Yantai 264000, China
    Chin Med J (Engl) 119:1563-6. 2006
  79. ncbi Simple scintigraphic parameters with Tc-99m galactosyl human serum albumin for clinical staging of chronic hepatocellular dysfunction
    K Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Takaramachi, Japan
    Ann Nucl Med 13:5-11. 1999
    ..In conclusion, the use of the ROI-area normalized nLHL is recommended instead of the conventional LHL15. The indices of LH15 and T-half could be alternatively used as practical parameters for clinical staging in liver function...
  80. ncbi [13C]-Galactose breath test: correlation with liver fibrosis in chronic hepatitis C
    F Mion
    Fédération des spécialités digestives, Hopital E Herriot, Lyon, France
    Eur J Clin Invest 29:624-9. 1999
    ..However, this test lacks sensitivity in early liver disease. The goal of this study was to evaluate a [13C]-galactose breath test (GBT) in a population of patients with chronic hepatitis C...
  81. ncbi Noninvasive measures of liver fibrosis
    Don C Rockey
    Department of Medicine, and the Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hepatology 43:S113-20. 2006
    ..The development of safe, inexpensive, and reliable noninvasive fibrosis measurement tools remains a research priority in clinical hepatology...
  82. ncbi Prevalence, outcome and associated factors of deranged liver function tests in patients on home parenteral nutrition
    W Luman
    Intestinal Failure Unit, Hope Hospital, Salford, Manchester, M6 8HD, UK
    Clin Nutr 21:337-43. 2002
    The prevalence of deranged liver function tests (LFT) in patients on long-term home parenteral nutrition (HPN) is poorly documented. The aim of our study was to document the prevalence of this complication and possible associated factors.
  83. ncbi Non-alcoholic steatohepatitis in type 2 diabetes mellitus
    Parijat Gupte
    Gastroenterology Center, Jagjivanram Hospital, Mumbai Central, Mumbai, Maharashtra, India
    J Gastroenterol Hepatol 19:854-8. 2004
    ..Hence we have studied its prevalence and correlation of biochemical parameters with histological grades of non-alcoholic fatty liver disease (NAFLD) in otherwise asymptomatic type 2 DM patients...
  84. ncbi Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B
    Morris Sherman
    Department of Medicine, Toronto General Hospital, Toronto, Ontario, Canada
    Gastroenterology 130:2039-49. 2006
    ..In preclinical and phase II studies, entecavir demonstrated potent antiviral activity against lamivudine-resistant HBV...
  85. ncbi Effects of taurine and ursodeoxycholic acid on liver function tests in patients with cystic fibrosis
    C Colombo
    Department of Pediatrics, University of Milan, Italy
    Acta Univ Carol Med (Praha) 36:148-51. 1990
    ..Standard liver function tests were determined before and after each period of treatment...
  86. doi First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage
    Jun Chen
    Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, P R China
    Toxicol Sci 108:81-9. 2009
    ..The results also demonstrate a risk of health effects from chronic exposure to MCs at least for populations with high levels of exposure, like these fishermen...
  87. ncbi Functional mapping of regional liver asialoglycoprotein receptor amount from single blood sample and SPECT
    Noriyuki Shuke
    Department of Radiology, Asahikawa Medical College, Asahikawa, Hokkaido, Japan
    J Nucl Med 44:475-82. 2003
    ....
  88. ncbi The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002
    George N Ioannou
    Research Enhancement Award Program, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Gastroenterol 101:76-82. 2006
    ..We aimed to describe the prevalence and associations of elevated serum aminotransferase activity in a recent, nationally representative U.S. survey...
  89. ncbi High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo
    Frank Tacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Hepatol 42:666-73. 2005
    ..Models of fatty liver diseases and fibrosis suggest a hepatoprotective effect of adiponectin, an adipocyte-derived hormone with antidiabetic, antiobesity, antiatherogenic and anti-inflammatory effects...
  90. ncbi Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C
    Vincent Leroy
    Département d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Hepatol 46:775-82. 2007
    ..The aim of this study was to compare the diagnostic performance of 6 scores (MP3, Fibrotest, Fibrometer, Hepascore, Forns' score and APRI)...
  91. ncbi Liver function tests in patients of pulmonary tuberculosis using four different drug regimens
    M Z Akbri
    Department of Biochemistry, Allama Iqbal Medical College, Lahore
    J Ayub Med Coll Abbottabad 13:5-10. 2001
    ..Antituberculous therapy causes derangement of hepatic functions revealed by disturbed liver function tests. The incidence of side effects may vary depending upon a number of factors...
  92. ncbi [Pre- and postoperative transaminase changes within the scope of gastric banding in morbid obesity]
    S Albert
    , Departement Innere Medizin, Kantonsspital St. Gallen
    Praxis (Bern 1994) 90:1459-64. 2001
    ..The normalisation of elevated liver enzymes correlates to the extent of weight reduction after gastric banding. Our data show reversible liver enzyme abnormalities, correlating to the degree of obesity...
  93. ncbi Review article: breath testing for human liver function assessment
    A Armuzzi
    Department of Internal Medicine, Catholic University, Rome, Italy
    Aliment Pharmacol Ther 16:1977-96. 2002
    ....
  94. ncbi Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease
    Sylvie Naveau
    Department of Hepato Gastroenterology, Hopital Antoine Beclere, Clamart, France
    Clin Gastroenterol Hepatol 3:167-74. 2005
    ..The aim of this study was to determine the diagnostic use of noninvasive markers of fibrosis in patients with chronic alcoholic liver disease...
  95. pmc Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R95. 2009
    ..We aimed to examine the correlation of serum resistin concentrations to parameters of inflammation, organ function, metabolism, disease severity and survival in critically ill patients...
  96. ncbi Should liver function tests be included in definitions of metabolic syndrome? Evidence from the association between liver function tests, components of metabolic syndrome and prevalent cardiovascular disease
    M C Devers
    Department of Diabetes, Glasgow Royal Infirmary, Glasgow, UK
    Diabet Med 25:523-9. 2008
    The definition of metabolic syndrome (MS) continues to be debated and does not include abnormal liver function tests (LFTs)...
  97. ncbi 13C-breath tests in hepatology (cytosolic liver function)
    F Perri
    Dpt of Gastroenterology and Digestive Endoscopy Casa Sollievo della Sofferenza, Hospital, IRCCS, San Giovanni Rotondo, Italy
    Eur Rev Med Pharmacol Sci 8:47-9. 2004
    ..Both BTs are not affected by enzymatic induction due to drugs which may interfere with the results of the classic "microsomial" BTs (such as the aminopyrine or caffeine BTs)...
  98. ncbi Seasonal variation in liver function tests: a time-series analysis of outpatient data
    Kazunori Miyake
    Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    Ann Clin Biochem 46:377-84. 2009
    Long-term physiological variations, such as seasonal variations, affect the screening efficiency at medical checkups. This study examined the seasonal variation in liver function tests using recently described data-mining methods.
  99. ncbi Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy
    Ferdinand W N M Wit
    National AIDS Therapy Evaluation Center, Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 186:23-31. 2002
    ..In 97% of cases, >or=1 risk factor was present. In HBV-coinfected patients using 3TC, continued use of 3TC should be considered, even if 3TC-resistant HIV strains develop...
  100. ncbi Validity of 13C-phenylalanine breath test to evaluate functional capacity of hepatocyte in patients with liver cirrhosis and acute hepatitis
    N Koeda
    First Department of Internal Medicine, Iwate Medical University, School of Medicine, 19 1 Uchimaru, Morioka 020 8505, Iwate, Japan
    Aliment Pharmacol Ther 21:851-9. 2005
    ..No definitive method for quantitative evaluation of hepatic function has as yet been established...
  101. doi Association of ADIPOR2 with liver function tests in type 2 diabetic subjects
    Abel Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, Girona, Spain
    Obesity (Silver Spring) 16:2308-13. 2008
    ..We studied whether common single-nucleotide polymorphisms (SNPs) in ADIPOR1 and ADIPOR2 are associated with liver function tests (LFTs) in human subjects with various degrees of insulin resistance.

Research Grants79

  1. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2009
    ..b>Liver function tests are obtained every 3 months and if elevated, patients are again screened for hepatitis B, C, and A;CMV, EBV,..
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2010
    ..b>Liver function tests are obtained every 3 months and if elevated, patients are again screened for hepatitis B, C, and A;CMV, EBV,..
  3. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2007
    ..b>Liver function tests are obtained every 3 months and if elevated, patients are again screened for hepatitis B, C, and A; CMV, ..
  4. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2012
    ..given to hepatitis B (HB) chronically infected pregnant women with a positive HBeAg test and normal liver function tests, from 28 weeks'gestation until two months postpartum to prevent perinatal transmission of hepatitis B ..
  5. TREATMENT OF ALCOHOLIC FIBROSIS WITH PHOSPHATIDYLCHOLINE
    Charles Lieber; Fiscal Year: 1993
    ..In addition to conventional liver function tests, outcome will be evaluated through liver biopsy and blood markers of fibrosis such as radioimmunoassays for ..
  6. ANTIRETROVIRAL ACTIVITY OF HYDROXYUREA ALONE AND IN COMBINATION WITH DDI
    Carol Dukes Hamilton; Fiscal Year: 1999
    ..women of child-bearing potential at Weeks12 and 24; CBC with MCV, differential and platelets; electrolytes, liver function tests, amylase, alkaline phosphatase and total bilirubin will be done at Weeks 2, 4, 8, 12, 18 and 24...
  7. ANTIRETROVIRAL ACTIVITY OF HYDROXYUREA ALONE AND IN COMBINATION WITH DDI
    Carol Dukes Hamilton; Fiscal Year: 2001
    ..women of child-bearing potential at Weeks12 and 24; CBC with MCV, differential and platelets; electrolytes, liver function tests, amylase, alkaline phosphatase and total bilirubin will be done at Weeks 2, 4, 8, 12, 18 and 24...
  8. STUDIES IN PORPHYRIA CUTANEA TARDA
    Karl Anderson; Fiscal Year: 2000
    ..observing the effect of treatment of PCT by repeated phlebotomy or low-dose chloroquine on abnormalities in liver function tests and on the presence of hepatitis C antibody and hepatitis C RNA in plasma; and (b) by observing the ..
  9. STUDIES IN PORPHYRIA CUTANEA TARDA
    Karl Anderson; Fiscal Year: 2001
    ..observing the effect of treatment of PCT by repeated phlebotomy or low-dose chloroquine on abnormalities in liver function tests and on the presence of hepatitis C antibody and hepatitis C RNA in plasma; and (b) by observing the ..
  10. STUDIES IN PORPHYRIA CUTANEA TARDA
    Karl Anderson; Fiscal Year: 2002
    ..observing the effect of treatment of PCT by repeated phlebotomy or low-dose chloroquine on abnormalities in liver function tests and on the presence of hepatitis C antibody and hepatitis C RNA in plasma; and (b) by observing the ..
  11. Effects of Simvastatin on CSF AD biomarkers in cognitively normal subjects
    Gail Li; Fiscal Year: 2009
    ..Adverse effects (including serum lipids, liver function tests, and creatine phosphokinase levels) will be monitored at 6-weeks and at 3-, 6-, and 12-months...
  12. Effects of Simvastatin on CSF AD biomarkers in cognitively normal subjects
    Gail Li; Fiscal Year: 2010
    ..Adverse effects (including serum lipids, liver function tests, and creatine phosphokinase levels) will be monitored at 6-weeks and at 3-, 6-, and 12-months...
  13. Hepatitis C Clinical Trial-Clinical Center
    Gyongyi Szabo; Fiscal Year: 2009
    ..studies;studies of predictors of disease progression including fatty liver, obesity, diabetes, quantitative liver function tests, serum fibrosis markers, esophageal varices, dietary constituents including coffee and caffeine, health ..
  14. Hepatitis C Clinical Trial-Clinical Center
    Jules L Dienstag; Fiscal Year: 2009
    ..studies;studies of predictors of disease progression including fatty liver, obesity, diabetes, quantitative liver function tests, serum fibrosis markers, esophageal varices, dietary constituents including coffee and caffeine, health ..
  15. MOLECULAR MECHANISMS IN GLYCOGEN STORAGE DISEASE TYPE III
    Priya Kishnani; Fiscal Year: 1999
    ..and clinical course of the disease within subtypes of GSD III, detailed studies are performed on liver ( liver function tests, abdominal CT)...
  16. AVERSION THERAPY OF ALCOHOLISM
    RALPH ELKINS; Fiscal Year: 1993
    ..Follow-up blood and urine will be collected for liver function tests and screens of psychoactive substance use...
  17. SELECTIVE PLASMA EXCHANGE THERAPY
    Jacek Rozga; Fiscal Year: 2003
    ..Survival time and changes in intracranial pressure, cerebral perfusion pressure, and standard liver function tests will be examined...
  18. RISK FACTORS FOR OSTEOPOROSIS IN THE ELDERLY
    Elizabeth Barrett Connor; Fiscal Year: 1992
    ..levels (including insulin, adrenal and sex hormones) & sex hormone binding globulin, BUN, creatinine, liver function tests, uric acid, calcium (total and ionized), inorganic phosphorous, albumin, and globulin & urinalysis ..
  19. BLOOD COAGULATION AND HEMORRHAGIC DISEASE
    Jessica Lewis; Fiscal Year: 1980
    ..Liver biopsies have been done in about 20 individuals with abnormal liver function tests. Pathology has varied from chronic persistent hepatitis to chronic active hepatitis and cirrhosis...
  20. Instrumentation for Creating Biological Stents and Occlusions
    FRED STERZER; Fiscal Year: 2010
    ..Gross and histological examinations, as well as liver function tests and imaging will be performed to determine optimum treatment parameters...
  21. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..NAFLD), which is associated with the metabolic syndrome, now represents the most common cause of abnormal liver function tests. "Thrifty genes" are genes that may have conferred a survival advantage to humans thousands of years ago, ..
  22. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2007
    ..NAFLD), which is associated with the metabolic syndrome, now represents the most common cause of abnormal liver function tests. "Thrifty genes" are genes that may have conferred a survival advantage to humans thousands of years ago, ..
  23. Early Antipseudomonal Therapy in Cystic Fibrosis
    Bonnie Ramsey; Fiscal Year: 2007
    ..reference to musculo-skeletal symptoms, renal function as measured by serum creatinine, hearing acuity, liver function tests, and complete blood count); clinical variables (occurrence of hospitalization during 18 months, proportion ..
  24. Early Antipseudomonal Therapy in Cystic Fibrosis
    Bonnie Ramsey; Fiscal Year: 2006
    ..reference to musculo-skeletal symptoms, renal function as measured by serum creatinine, hearing acuity, liver function tests, and complete blood count); clinical variables (occurrence of hospitalization during 18 months, proportion ..
  25. Early Antipseudomonal Therapy in Cystic Fibrosis
    Bonnie Ramsey; Fiscal Year: 2005
    ..reference to musculo-skeletal symptoms, renal function as measured by serum creatinine, hearing acuity, liver function tests, and complete blood count); clinical variables (occurrence of hospitalization during 18 months, proportion ..
  26. Early Antipseudomonal Therapy in Cystic Fibrosis
    Bonnie Ramsey; Fiscal Year: 2004
    ..reference to musculo-skeletal symptoms, renal function as measured by serum creatinine, hearing acuity, liver function tests, and complete blood count); clinical variables (occurrence of hospitalization during 18 months, proportion ..
  27. TRIAL OF EBV SPECIFIC CYTOTOXIC T LYMPHOCYTES WITH EBV ASSOCIATED MALIGNANCIES
    Richard Ambinder; Fiscal Year: 1999
    ..One patient post-liver transplant developed an elevation of liver function tests (LFTs) prior to completion of 4 infusions...
  28. DIAGNOSTIC TEST TO EVALUATE IRRITABLE BOWEL SYNDROME
    BRIAN CRAINE; Fiscal Year: 1999
    ..obligating the patient to undergo a series of expensive tests such as endoscopy, complete blood counts, liver function tests, serum electrolytes, erythrocyte sedimentation rate, urine analysis, stool cultures and X-ray studies...
  29. RIFAPENTINE FOR RELAPSE AMONG HIV SEROPOSITIVE & SELECTED SERONEGATIVE
    Carol Dukes Hamilton; Fiscal Year: 1999
    ..After informed consent has been obtained and if pre-study liver function tests are within the enrollment parameters, each patient receives a single dose of INH and either rifampin or ..
  30. RIFAPENTINE FOR RELAPSE AMONG HIV SEROPOSITIVE & SELECTED SERONEGATIVE
    Carol Dukes Hamilton; Fiscal Year: 2001
    ..After informed consent has been obtained and if pre-study liver function tests are within the enrollment parameters, each patient receives a single dose of INH and either rifampin or ..
  31. RIFAPENTINE FOR RELAPSE AMONG HIV SEROPOSITIVE & SELECTED SERONEGATIVE
    Carol Dukes Hamilton; Fiscal Year: 2000
    ..After informed consent has been obtained and if pre-study liver function tests are within the enrollment parameters, each patient receives a single dose of INH and either rifampin or ..
  32. EFFECT OF AGING--RETINOIC ACID RECEPTOR GENE EXPRESSION
    MONICA PEACOCKE; Fiscal Year: 1990
    ..All subjects will be interviewed, and have blood samples drawn for liver function tests, at admission and at 6 month follow-up periods for two years...
  33. METABOLIC LIVER FUNCTION TEST TO PREDICT MORBIDITY/MORTALITY IN LIVER CIRRHOSIS
    Mitchell Shiffman; Fiscal Year: 2000
    ..There will be outpatient visits to the General Clinical Research Center where metabolic liver function tests, blood tests, pre-transplant testing, and vital sign assessment will be done...
  34. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2005
    ..Design: Obese Hispanic children and their nonobese siblings will be screened for NAFLD using serum liver function tests; total sample size will be 1000...
  35. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2004
    ..Design: Obese Hispanic children and their nonobese siblings will be screened for NAFLD using serum liver function tests; total sample size will be 1000...
  36. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2003
    ..In a pilot study of anti-retroviral therapy with Combivir, 40% of patients completely normalized their liver function tests and there was a significant reversal of ductopenia on liver biopsy...
  37. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    ..In a pilot study of anti-retroviral therapy with Combivir, 40% of patients completely normalized their liver function tests and there was a significant reversal of ductopenia on liver biopsy...
  38. ALCOHOL AND THE CELL
    Emanuel Rubin; Fiscal Year: 1990
    ..and on the sensitivity to oxidative stress in relation to cell injury; and the development of non-invasive liver function tests by 31p NMR...
  39. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2005
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  40. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2006
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  41. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2002
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  42. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2004
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  43. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2000
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  44. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2003
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  45. ACUTE PHASE RESPONSE IN THE PERFUSED SWINE LIVER
    THEODORE KRAMER; Fiscal Year: 1993
    ..Physiologic methods used to evaluate the response of the liver.will comprise liver function tests, biochemical methods will comprise purification and quantitation of acute phase proteins, immunologic ..
  46. Tumor Neovasculature Vector Targeting
    Albert Deisseroth; Fiscal Year: 2002
    ..will be monitored by a panel of tests during and after treatment, including several types of blood and liver function tests. Efficacy will be monitored by measurements of injected skin tumors, and also of skin tumors and internal ..
  47. Dietary Micronutrients &Weight Loss in Liver Metabolism &Fat Content in Humans
    Elizabeth Jane Parks; Fiscal Year: 2011
    ..Clinical studies have shown that weight loss can reduce hepatosteatosis, improve liver function tests, and reduce liver fibrosis in NASH...
  48. Alcohol Associated Outcomes Among HIV+/-Aging Veterans
    Amy Justice; Fiscal Year: 2002
    ..Follow Back will be self completed by all patients and validated by interview in a subset, and additional liver function tests will be analyzed on banked specimens (CDT, GGT, ALT, and AST)...
  49. Alcohol Associated Outcomes Among HIV+/-Aging Veterans
    Amy Justice; Fiscal Year: 2001
    ..Follow Back will be self completed by all patients and validated by interview in a subset, and additional liver function tests will be analyzed on banked specimens (CDT, GGT, ALT, and AST)...
  50. Tumor Neovasculature Vector Targeting
    Albert Deisseroth; Fiscal Year: 2003
    ..will be monitored by a panel of tests during and after treatment, including several types of blood and liver function tests. Efficacy will be monitored by measurements of injected skin tumors, and also of skin tumors and internal ..
  51. HIV-Infected Patients' Experiences with HCV Treatment
    Carol Bova; Fiscal Year: 2003
    ..data (HCV treatment adherence, HIV RNA, HCV RNA, HCV genotype, liver pathology, complete blood counts, liver function tests, HIV illness stage and co-treatment with antiretroviral agents)...
  52. Obesity and Type II Diabetes Pilot
    ANNE RENTFRO; Fiscal Year: 2003
    ..blood pressure, acanthosis nigricans, fasting plasma glucose, insulin, lipid profile, C-reactive protein, liver function tests, demographic factors, physical activity and nutritional habits will be recorded...
  53. Core-Statistical and Economic Analysis
    Adriana Perez; Fiscal Year: 2003
    ..blood pressure, acanthosis nigricans, fasting plasma glucose, insulin, lipid profile, C-reactive protein, liver function tests, demographic factors, physical activity and nutritional habits will be recorded...
  54. Epidemiology of HCV Infection among Egyptian Children
    Gamal Esmat; Fiscal Year: 2004
    ..assess liver function and morbidity in HCV infected children and their controls with clinical examinations, liver function tests, and abdominal ultrasound...
  55. Epidemiology of HCV Infection among Egyptian Children
    Gamal Esmat; Fiscal Year: 2005
    ..assess liver function and morbidity in HCV infected children and their controls with clinical examinations, liver function tests, and abdominal ultrasound...
  56. Epidemiology of HCV Infection among Egyptian Children
    Gamal Esmat; Fiscal Year: 2006
    ..assess liver function and morbidity in HCV infected children and their controls with clinical examinations, liver function tests, and abdominal ultrasound...
  57. Murine models of non-alcoholic steatohepatitis
    Alexander Igolnikov; Fiscal Year: 2005
    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the United States...
  58. Murine models of non-alcoholic steatohepatitis
    Alexander Igolnikov; Fiscal Year: 2004
    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the United States...
  59. A 13C-AMINO ACID BREATH TEST MEASURING LIVER FUNCTION
    David Wagner; Fiscal Year: 1992
    Biochemical liver function tests have been used by physicians in the identification and management of liver disease. These static tests include measurements of albumin, bilirubin, enzymes and prothrombin time...
  60. BEH PHARM TREATMENTS FOR ALCOHOL/NICOTINE DEPENDENCE
    Joy Schmitz; Fiscal Year: 2000
    ..Alcohol consumption will be measured by self-report, breath alcohol readings, collateral reports, and liver function tests. Primary efficacy parameters for drinking and smoking will include time to lapse/relapse and cumulative ..
  61. BEH PHARM TREATMENTS FOR ALCOHOL/NICOTINE DEPENDENCE
    Joy Schmitz; Fiscal Year: 2001
    ..Alcohol consumption will be measured by self-report, breath alcohol readings, collateral reports, and liver function tests. Primary efficacy parameters for drinking and smoking will include time to lapse/relapse and cumulative ..
  62. BEH PHARM TREATMENTS FOR ALCOHOL/NICOTINE DEPENDENCE
    Joy Schmitz; Fiscal Year: 1999
    ..Alcohol consumption will be measured by self-report, breath alcohol readings, collateral reports, and liver function tests. Primary efficacy parameters for drinking and smoking will include time to lapse/relapse and cumulative ..
  63. Murine models of non-alcoholic steatohepatitis
    Alexander Igolnikov; Fiscal Year: 2003
    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the United States...