liver function tests

Summary

Top Publications

  1. ncbi Histological changes in the liver of morbidly obese patients: correlation with metabolic parameters
    Anna Maria Wolf
    Department of Visceral and Transplantation Surgery, University Hospital Ulm, Germany
    Obes Surg 15:228-37. 2005
  2. ncbi Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    Cecilia Söderberg
    Department of Medicine, Karolinska Institute, Solna, Stockholm, Sweden
    Hepatology 51:595-602. 2010
  3. pmc Evaluation of abnormal liver function tests
    J K Limdi
    Tameside General Hospital, Ashton under Lyne, Manchester, UK
    Postgrad Med J 79:307-12. 2003
  4. ncbi Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort
    Matthew J Armstrong
    Centre for Liver Research, NIHR Liver Biomedical Research Unit, University of Birmingham, UK
    J Hepatol 56:234-40. 2012
  5. ncbi AGA technical review on the evaluation of liver chemistry tests
    Richard M Green
    Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 123:1367-84. 2002
  6. pmc Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    Eur J Heart Fail 11:170-7. 2009
  7. ncbi Autoimmune hepatitis
    Edward L Krawitt
    Department of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
    N Engl J Med 354:54-66. 2006
  8. ncbi Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial
    Andrew P Ambrosy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Heart Fail 14:302-11. 2012
  9. ncbi 13C-breath tests: current state of the art and future directions
    B Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Dig Liver Dis 39:795-805. 2007
  10. ncbi The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients
    Sherene Shalhub
    Department of Surgery and Interdisciplinary Obesity Study Group, University of South Florida Health Sciences Center, Tampa, FL 33601, USA
    Obes Surg 14:54-9. 2004

Research Grants

Detail Information

Publications322 found, 100 shown here

  1. ncbi Histological changes in the liver of morbidly obese patients: correlation with metabolic parameters
    Anna Maria Wolf
    Department of Visceral and Transplantation Surgery, University Hospital Ulm, Germany
    Obes Surg 15:228-37. 2005
    ....
  2. ncbi Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    Cecilia Söderberg
    Department of Medicine, Karolinska Institute, Solna, Stockholm, Sweden
    Hepatology 51:595-602. 2010
    ..69; 95% confidence interval [CI], 1.24-2.25); subjects with bland steatosis, a 55% increase (SMR, 1.55; 95% CI, 0.98-2.32; P = 0.062); and subjects with NASH, 86% (SMR, 1.86; 95% CI, 1.19-2.76; P = 0.007)...
  3. pmc Evaluation of abnormal liver function tests
    J K Limdi
    Tameside General Hospital, Ashton under Lyne, Manchester, UK
    Postgrad Med J 79:307-12. 2003
    Interpretation of abnormalities in liver function tests is a common problem faced by clinicians. This has become more common with the introduction of automated routine laboratory testing...
  4. ncbi Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort
    Matthew J Armstrong
    Centre for Liver Research, NIHR Liver Biomedical Research Unit, University of Birmingham, UK
    J Hepatol 56:234-40. 2012
    ..This study seeks to calculate the range of disease severity of NAFLD in a primary care setting...
  5. ncbi AGA technical review on the evaluation of liver chemistry tests
    Richard M Green
    Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 123:1367-84. 2002
  6. pmc Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    Eur J Heart Fail 11:170-7. 2009
    ..The prevalence and importance of liver function test (LFT) abnormalities in a large contemporary cohort of heart failure patients have not been systematically evaluated...
  7. ncbi Autoimmune hepatitis
    Edward L Krawitt
    Department of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
    N Engl J Med 354:54-66. 2006
  8. ncbi Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial
    Andrew P Ambrosy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Heart Fail 14:302-11. 2012
    Abnormal liver function tests (LFTs) are common in ambulatory heart failure (HF). The aim of this study was to characterize abnormal LFTs during index hospitalization.
  9. ncbi 13C-breath tests: current state of the art and future directions
    B Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Dig Liver Dis 39:795-805. 2007
    ..The stable isotope technique presents an elegant, non-invasive diagnostic tool promising further options of clinical applications. This review is aimed at providing an overview on the relevant clinical applications of 13C-breath tests...
  10. ncbi The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients
    Sherene Shalhub
    Department of Surgery and Interdisciplinary Obesity Study Group, University of South Florida Health Sciences Center, Tampa, FL 33601, USA
    Obes Surg 14:54-9. 2004
    ..Prevalence of NASH in bariatric patients is unknown. Our aim was to determine the role of routine liver biopsy in managing bariatric patients...
  11. pmc High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis
    Keith D Lindor
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 50:808-14. 2009
    ..01) and 2.1 times greater for death, transplantation, or minimal listing criteria (P = 0.038). Serious adverse events were more common in the UDCA group than the placebo group (63% versus 37% [P < 0.01])...
  12. pmc Safety and efficacy of nevirapine- and efavirenz-based antiretroviral treatment in adults treated for TB-HIV co-infection in Botswana
    L K Shipton
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 13:360-6. 2009
    ..The safety and efficacy of nevirapine (NVP) and efavirenz (EFV) based highly active antiretroviral treatment (ART) with concurrent anti-tuberculosis treatment in sub-Saharan Africa has not been well established...
  13. ncbi Evidence-based incorporation of serum sodium concentration into MELD
    Scott W Biggins
    University of California San Francisco, San Francisco, California, USA
    Gastroenterology 130:1652-60. 2006
    ..Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation...
  14. pmc Liver enzyme alteration: a guide for clinicians
    Edoardo G Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    CMAJ 172:367-79. 2005
    ....
  15. ncbi Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring
    D R Dufour
    Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
    Clin Chem 46:2050-68. 2000
    ..To review information on the use of laboratory tests in screening, diagnosis, and monitoring of acute and chronic hepatic injury...
  16. ncbi Noninvasive measures of liver fibrosis
    Don C Rockey
    Department of Medicine, and the Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hepatology 43:S113-20. 2006
    ..The development of safe, inexpensive, and reliable noninvasive fibrosis measurement tools remains a research priority in clinical hepatology...
  17. ncbi Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study
    L Bathum
    Department of Clinical Biochemistry, Odense University Hospital, DK 5000 Odense C, Denmark
    Clin Chem 47:81-7. 2001
    Biochemical liver function tests are widely used in the clinic and are some of the most frequently used tests in screening for diseases in older age groups...
  18. ncbi Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town
    Gaspare Maria Pendino
    Divisione di Medicina 1, Policlinico Madonna della Consolazione, Reggio Calabria, Italy
    Hepatology 41:1151-9. 2005
    ....
  19. pmc Measuring markers of liver function using a micropatterned paper device designed for blood from a fingerstick
    Sarah J Vella
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States
    Anal Chem 84:2883-91. 2012
    ..This device illustrates a type of test useable for a range of assays in resource-poor settings...
  20. pmc The prognostic role of WHO classification, urinary 5-hydroxyindoleacetic acid and liver function tests in metastatic neuroendocrine carcinomas of the gastroenteropancreatic tract
    V Formica
    Department of Medicine, Royal Marsden Hospital, London and Sutton, Surrey, UK
    Br J Cancer 96:1178-82. 2007
    ..In a WDNEC-restricted analysis, abnormal liver function tests (LFTs) and elevated urinary 5-hydroxyindoleacetic acid (u5HIAA) were independent prognostic factors for ..
  21. ncbi Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure
    Hisahito Shinagawa
    Department of Cardio angiology, Kitasato University School of Medicine, Sagamihara, Japan
    Circ J 72:364-9. 2008
    The aim of this study was to analyze the relationship between abnormal liver function tests (LFTs) coincident with heart failure (HF) exacerbation and subsequent long-term outcome in patients with chronic HF.
  22. ncbi Hepatocellular necrosis, apoptosis, and proliferation after transcatheter arterial embolization or chemoembolization in a standardized rabbit model
    Yong Wang
    Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie fang Rd, Wuhan 430022, China
    J Vasc Interv Radiol 22:1606-12. 2011
    ..To evaluate the effect of transcatheter arterial chemoembolization versus transcatheter arterial embolization on hepatocellular damage, apoptosis, proliferation, and proinflammatory response in a rabbit VX2 tumor model...
  23. pmc The utility of liver function tests for mortality prediction within one year in primary care using the algorithm for liver function investigations (ALFI)
    David J McLernon
    Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 7:e50965. 2012
    Although liver function tests (LFTs) are routinely measured in primary care, raised levels in patients with no obvious liver disease may trigger a range of subsequent expensive and unnecessary management plans...
  24. pmc Muscular exercise can cause highly pathological liver function tests in healthy men
    Jonas Pettersson
    AstraZeneca R and D Lund, Lund, Sweden
    Br J Clin Pharmacol 65:253-9. 2008
    ..Physical exercise can result in transient elevations of liver function tests. There is no consensus in the literature on which forms of exercise may cause changes in liver function ..
  25. pmc Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows
    Felix Diaz González
    Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Vet Sci 12:251-5. 2011
    ..During early lactation, 30% of cows suffered hepatic lipidosis as detected by levels of AST. Compromised hepatic function was observed in early lactation cows as shown by lower concentrations of glucose, total protein, and urea...
  26. pmc Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
    Winston Dunn
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Gastroenterol 103:2263-71. 2008
    ..The current study compared the survival of subjects with and without suspected NAFLD in a population-based cohort, and placed the finding in the context of previously published case series...
  27. ncbi Prognostic value of indocyanine green elimination assessed with LiMON in septic patients
    Mehmet Turan Inal
    Department of Anesthesiology, Trakya University Medical Faculty, 22030 Edirne, Turkey
    J Crit Care 24:329-34. 2009
    ..Sepsis is the most frequent infection with high mortality rates in intensive care units (ICUs), and the prediction of outcome is important in the decision-making process...
  28. ncbi Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Am J Gastroenterol 103:1136-44. 2008
    ..We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV)...
  29. ncbi Postoperative changes in liver function tests: randomized comparison of low- and high-pressure laparoscopic cholecystectomy
    S Hasukic
    Department of Surgery, University Clinical Center Tuzla, Faculty of Medicine, University of Tuzla, Trnovac b b, 75, 000, Tuzla, Bosnia Herzegovina
    Surg Endosc 19:1451-5. 2005
    ..This study evaluated the changes in liver function tests after high-pressure LC (HPLC; 14 mmHg) and low-pressure LC (LPLC; 7 mmHg).
  30. ncbi Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study
    Philippe Halfon
    Department of Virology, Alphabio Laboratory, 23 Street of Friedland, 13006 Marseille, France
    Am J Gastroenterol 101:547-55. 2006
    ..The aim of this study was to perform an external validation of FT and AT and to study the discordances between FT/AT and liver biopsy in patients with chronic hepatitis C...
  31. ncbi Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B
    Morris Sherman
    Department of Medicine, Toronto General Hospital, Toronto, Ontario, Canada
    Gastroenterology 130:2039-49. 2006
    ..In preclinical and phase II studies, entecavir demonstrated potent antiviral activity against lamivudine-resistant HBV...
  32. ncbi Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats
    Gene T Yocum
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Radiology 235:547-52. 2005
    ....
  33. ncbi Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients
    Chung Bao Hsieh
    Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China
    World J Gastroenterol 10:2394-6. 2004
    ..To investigate whether the non-invasive real-time Indocyanine green (ICG) clearance is a sensitive index of liver viability in patients before, during, and after liver transplantation...
  34. ncbi A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid
    V N Santos
    Disciplina de Gastroenterologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 36:723-9. 2003
    ..These results show that ursodeoxycholic acid is able to reduce serum levels of hepatic enzymes in patients with nonalcoholic fatty liver disease, but this effect is not related to modifications in liver fat content...
  35. ncbi Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
    Sasiwarang Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
    Diabetes Care 28:2913-8. 2005
    ..We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk...
  36. pmc The association of alanine transaminase with aging, frailty, and mortality
    David G Le Couteur
    Centre for Education and Research on Ageing, Concord RG Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia
    J Gerontol A Biol Sci Med Sci 65:712-7. 2010
    ..Low ALT activity is a predictor of reduced survival; however, this seems to be mediated by its association with frailty and increasing age. ALT has potential value as a novel biomarker of aging...
  37. ncbi Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests
    D R Dufour
    Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
    Clin Chem 46:2027-49. 2000
    ..To review information on performance characteristics for tests that are commonly used to identify acute and chronic hepatic injury...
  38. ncbi [13C]-Galactose breath test: correlation with liver fibrosis in chronic hepatitis C
    F Mion
    Fédération des spécialités digestives, Hopital E Herriot, Lyon, France
    Eur J Clin Invest 29:624-9. 1999
    ..However, this test lacks sensitivity in early liver disease. The goal of this study was to evaluate a [13C]-galactose breath test (GBT) in a population of patients with chronic hepatitis C...
  39. ncbi Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virus-infected patients treated for non-Hodgkin lymphoma
    Marcello Persico
    Blood 99:724-5. 2002
  40. ncbi Prevalence of hepatitis B and C seromarkers and abnormal liver function tests among hemophiliacs in Guilan (northern province of Iran)
    Fariborz Mansour-Ghanaei
    Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
    Med Sci Monit 8:CR797-800. 2002
    The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnormal liver function tests among hemophiliacs in Guilan province, Iran.
  41. ncbi Adiponectin, hepatocellular dysfunction and insulin sensitivity
    Abel Lopez-Bermejo
    Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
    Clin Endocrinol (Oxf) 60:256-63. 2004
    ....
  42. ncbi Liver function tests and their interpretation
    B R Thapa
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pediatr 74:663-71. 2007
    b>Liver function tests (LFT) are a helpful screening tool, which are an effective modality to detect hepatic dysfunction...
  43. ncbi Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral therapy
    E Martinez
    Unit of Infectious Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, Barcelona, Spain
    AIDS 15:1261-8. 2001
    ..To assess the incidence and risk factors for hepatotoxicity associated with nevirapine...
  44. ncbi Pretreatment of male BALB/c mice with beta-ionone potentiates thioacetamide-induced hepatotoxicity
    T C Jeong
    Toxicology Research Center, Korea Research Institute of Chemical Technology, Taejon, South Korea
    Toxicol Lett 105:39-46. 1999
    ..our present results suggest that beta-ionone may be a useful model inducer of P450 enzyme(s) in studying toxic mechanism of certain chemicals which require metabolic activation by P450s in mice...
  45. ncbi Review article: the assessment of liver function using breath tests
    Y Ilan
    Liver Unit, Department of Medicine, Hebrew University, Hadassah Medical Center, Jerusalem, Israel
    Aliment Pharmacol Ther 26:1293-302. 2007
    ..The recent development of a real-time, point-of-care liver function breath test has made it straightforward to assess the metabolic function of the liver...
  46. ncbi Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation
    Ming Huan Shyu
    Department of Food Science and Biotechnology, National Chung Hsing University, 250, Kuokuang Road, Taiching 402, Taiwan
    Food Chem Toxicol 46:3707-13. 2008
    ..Taken together, our data indicate that EHT can efficiently inhibit CCl(4)-induced liver fibrosis in rats. EHT may therefore be a useful functional food for preventing liver fibrosis...
  47. ncbi A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients
    Guilherme M Campos
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 0790, USA
    Hepatology 47:1916-23. 2008
    ..3; 95% CI, 1.4-8.0), and non-Black race (OR, 8.4; 95% CI, 1.9-37.1). A NASH Clinical Scoring System for Morbid Obesity was derived to predict the probability of NASH in four categories (low, intermediate, high, and very high)...
  48. ncbi Health outcomes following liver function testing in primary care: a retrospective cohort study
    David J McLernon
    Medical Statistics Team, Section of Population Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
    Fam Pract 26:251-9. 2009
    patients who present with abnormal liver function tests (LFTs) in primary care and no obvious symptoms can be difficult to manage.
  49. pmc Epidemiology and genetic epidemiology of the liver function test proteins
    Nilufer Rahmioglu
    Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
    PLoS ONE 4:e4435. 2009
    ..The liver function test (LFT) is among the most commonly used clinical investigations to assess hepatic function, severity of liver diseases and the effect of therapies, as well as to detect drug-induced liver injury (DILI)...
  50. ncbi Brief communication: clinical implications of short-term variability in liver function test results
    Mariana Lazo
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 148:348-52. 2008
    ..Clinicians sometimes order liver tests as part of a screening examination or general work-up. Current guidelines do not recommend routine retesting of abnormal results in asymptomatic patients...
  51. ncbi Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities
    Michael D McGoon
    Mayo Clinic, Rochester, MN 55905, USA
    Chest 135:122-9. 2009
    ..Because ambrisentan may provide benefits in PAH patients who have discontinued ERA therapy due to LFT abnormalities, we evaluated the safety and efficacy of ambrisentan in this patient population...
  52. ncbi Elevation of liver function tests in severe anorexia nervosa
    R Hill Harris
    Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA
    Int J Eat Disord 46:369-74. 2013
    ..The purpose of this article is to clarify the finding of liver function test abnormalities in anorexia nervosa (AN)...
  53. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
    ..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
  54. ncbi Liver function tests in patients with acute heart failure
    Jan Biegus
    Centre for Heart Diseases, 4th Military Hospital, Wrocław, Poland
    Pol Arch Med Wewn 122:471-9. 2012
    ..Acute heart failure (AHF) is associated with multiorgan dysfunction, which may unfavorably affect prognosis...
  55. ncbi Elevation of liver function tests after laparoscopic gastrectomy using a Nathanson liver retractor
    Yousuke Kinjo
    Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    World J Surg 35:2730-8. 2011
    Although pneumoperitoneum has been suspected as a possible cause of transient elevation of liver function tests (LFTs) after laparoscopic surgery, liver damage by direct retraction could also influence postoperative LFTs...
  56. pmc Liver function tests and risk prediction of incident type 2 diabetes: evaluation in two independent cohorts
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e51496. 2012
    b>Liver function tests might predict the risk of type 2 diabetes. An independent study evaluating utility of these markers compared with an existing prediction model is yet lacking.
  57. pmc The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit
    L Purkins
    Pfizer Global Research and Development, Pfizer Ltd, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
    Br J Clin Pharmacol 57:199-208. 2004
    To investigate the effect of diet upon liver function tests and serum lipids within the restricted environment of a Phase I unit.
  58. pmc Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh
    Khairul Islam
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh
    Environ Health 10:64. 2011
    ..However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented...
  59. ncbi Non ominous changes in liver function tests after laparoscopic cholecystectomy
    Alan A Saber
    J Gastrointestin Liver Dis 16:427-8. 2007
  60. ncbi Predicting liver failure following major hepatectomy
    G Garcea
    Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia
    Dig Liver Dis 41:798-806. 2009
    ..Published data would not suggest any difference in mortality, morbidity or liver failure rates between these groups. This review outlines and presents the evidence for pre-operative quantification of functional liver remnant volume...
  61. pmc Hepatic changes in the failing Fontan circulation
    Christoph H Kiesewetter
    Southampton General Hospital, University Hospitals Southampton, Southampton, UK
    Heart 93:579-84. 2007
    ..The failing Fontan circulation is associated with hepatic impairment. The nature of this liver injury is poorly defined...
  62. pmc Could quantitative liver function tests gain wide acceptance among hepatologists?
    Giovanni Tarantino
    World J Gastroenterol 15:3457-61. 2009
    ..Furthermore, who are the operators that should order these tests? Advances in analytic methods are expected to allow quantitative liver function tests to be used in clinical practice.
  63. ncbi Coagulation dynamics and platelet functions in obstructive jaundiced patients
    Tebessum Cakir
    Marmara University School of Medicine, Department of General Surgery, Istanbul, Turkey
    J Gastroenterol Hepatol 24:748-51. 2009
    ..All of the body systems are affected by increased levels of bilirubin. The aim of this study is to investigate the function of platelets and clotting dynamics in patients with obstructive jaundice...
  64. ncbi The asymptomatic outpatient with abnormal liver function tests
    Michael Krier
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 750 Welch Road, Suite 210, Stanford, CA 94304, USA
    Clin Liver Dis 13:167-77. 2009
    ..and hepatic synthetic measures (prothrombin time (PT) and serum albumin level) are referred to as liver function tests (LFTs)...
  65. ncbi Anicteric cholangiopathy in schistosomiasis patients
    Paulo Eugenio Brant
    Department of Medicine, Universidade Federal de Sao Paulo, Rua Jabuticabeiras 807, 05674 011 São Paulo, Brazil
    Acta Trop 108:218-21. 2008
    ..We now describe the presence of cholangiopathy in these patients...
  66. ncbi Acoustic radiation force impulse elastography for chronic liver disease: comparison with ultrasound-based scores of experienced radiologists, Child-Pugh scores and liver function tests
    Ji Eun Kim
    Department of Radiology, Seoul National University Hospital, Seoul, Korea
    Ultrasound Med Biol 36:1637-43. 2010
    ..performance for diagnosis of chronic liver disease and correlates better with Child-Pugh scores and liver function tests, compared with an ultrasound (US) scoring system based on visual assessment of conventional B-mode US ..
  67. pmc Should patients with abnormal liver function tests in primary care be tested for chronic viral hepatitis: cost minimisation analysis based on a comprehensively tested cohort
    David T Arnold
    School of Medicine, Cardiff University, Cardiff, UK
    BMC Fam Pract 12:9. 2011
    b>Liver function tests (LFTs) are ordered in large numbers in primary care, and the Birmingham and Lambeth Liver Evaluation Testing Strategies (BALLETS) study was set up to assess their usefulness in patients with no pre-existing or self-..
  68. ncbi Effects of varying intraperitoneal pressure on liver function tests during laparoscopic cholecystectomy
    Ranjan Gupta
    Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Laparoendosc Adv Surg Tech A 23:339-42. 2013
    ..The use of low-pressure pneumoperitoneum in the range of 8-10 mm Hg has been shown to reduce the adverse physiological changes without affecting the outcome of surgery...
  69. ncbi "Liver function tests" are not always tests of liver function
    D N Korones
    Department of Pediatrics, University of Rochester, School of Medicine and Dentistry, Children s Hospital at Strong, New York 14642, USA
    Am J Hematol 66:46-8. 2001
    ..Hematologists/oncologists should consider obtaining a serum CK to rule out muscle disease in patients with unexplained elevations of AST, ALT, and LDH...
  70. ncbi Nuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation
    Wilmar de Graaf
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Nucl Med 51:742-52. 2010
    ..In liver transplantation, these methods are used to assess graft function and biliary complications...
  71. ncbi Noninvasive quantitative testing of liver function using ultrasonography in patients with cirrhosis
    Guo Zhen Yan
    Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    Hepatogastroenterology 53:15-20. 2006
    ....
  72. ncbi Background incidence of liver chemistry abnormalities in a clinical trial population without underlying liver disease
    John G Weil
    WW Epidemiology, Neurosciences and International Support, GlaxoSmithKline Research and Development Ltd, New Frontiers Science Park, South Third Avenue, Harlow, Essex CM19 5AW, UK
    Regul Toxicol Pharmacol 52:85-8. 2008
    ..The study was undertaken to determine the background rates of liver chemistry abnormalities in clinical trial populations without underlying liver disease...
  73. ncbi Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:283-7. 2008
    When the liver function tests are aggravated after starting antithyroid drugs (ATDs) in Graves' hyperthyroidism, discontinuation of ATDs is generally considered...
  74. ncbi Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure
    N De Liguori Carino
    Supra Regional Hepatobiliary Unit, University Hospital Aintree, Liverpool, L9 7AL, UK
    Eur J Surg Oncol 35:957-62. 2009
    ..The aim was to assess the relationship between pre and post-operative ICG plasma disappearance rate (ICG PDR %/min) values and the onset of post-hepatectomy liver dysfunction...
  75. ncbi Living liver donor death related to complications of myeloma
    Emmanuel Melloul
    Department of HPB Surgery and Liver Transplantation, Hospital Beaujon, Clichy, France
    Liver Transpl 15:326-9. 2009
    ..This unusual cause of donor death after right hepatectomy reinforces the need for an extensive preoperative assessment. We advocate the addition of urinary protein loss and electrophoresis to the standard donor assessment protocol...
  76. ncbi Evaluation of ornithine carbamoyl transferase and other serum and liver-derived analytes in diagnosis of fatty liver and postsurgical outcome of left-displaced abomasum in dairy cows
    Emmanouil Kalaitzakis
    Clinic of Farm Animals, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
    J Am Vet Med Assoc 229:1463-71. 2006
    ....
  77. ncbi Perioperative outcome after laparoscopic radiofrequency ablation of liver tumors: an analysis of 521 cases
    E Berber
    Department of General Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Surg Endosc 21:613-8. 2007
    ..Understanding the morbidity and laboratory changes after RFA is important for operative indications and perioperative management...
  78. ncbi Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 53:2623-32. 2004
    ..In conclusion, AST and ALT independently predict type 2 diabetes. Baseline elevations of these markers may reflect NAFLD or related pathologies...
  79. ncbi Liver function tests: their role in the diagnosis of hepatobiliary diseases
    Joseph A Knight
    Division of Education at the Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Infus Nurs 28:108-17. 2005
    ..Although liver function tests are critical in recognizing the presence of liver disease and its specific diagnosis, the interpretation of ..
  80. ncbi Liver function tests and statins
    Philippe J Zamor
    Department of Medicine, Center for Liver Diseases and Transplantation, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Curr Opin Cardiol 26:338-41. 2011
    ..To discuss recent data on statins in patients with elevated liver tests...
  81. ncbi Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers
    Mireen Friedrich-Rust
    Department of Internal Medicine, JW Goethe University Clinic, Frankfurt, Germany
    J Thorac Cardiovasc Surg 135:560-7. 2008
    ..Therefore, early detection of fibrosis is essential to identify patients at risk. Transient elastography has been evaluated for noninvasive staging of liver fibrosis in a multitude of studies...
  82. ncbi Hepatotoxic effects of therapies for tuberculosis
    Bahaa E Senousy
    Internal Medicine Department, Ain Shams University, Abbassia 11566, Cairo, Egypt
    Nat Rev Gastroenterol Hepatol 7:543-56. 2010
    ....
  83. ncbi Simple clinical variables predict liver histology in hepatitis C: prospective validation of a clinical prediction model
    Joseph Romagnuolo
    Digestive Disease Center, University of South Carolina, 96 Jonathon Lucas Street, PO Box 250 327, Charleston, SC 29425, USA
    Scand J Gastroenterol 40:1365-71. 2005
    ..Absence of predictors also predicted a lack of inflammation and fibrosis. Our aim was prospectively to validate this clinical prediction model using an independent multicenter sample...
  84. ncbi A novel cause for abnormal liver function tests in pregnancy and the puerperium: non-alcoholic fatty liver disease
    L M Page
    Department of Obstetrics and Gynaecology, West Middlesex University Hospital, Isleworth, UK
    BJOG 118:1532-5. 2011
    ..We suggest that NAFLD should also be considered as a cause for abnormal liver function tests during pregnancy...
  85. pmc Liver function tests: defining what's normal
    Paul Roderick
    Community Clinical Sciences Research Division, University of Southampton, B Floor, South Academic Block, Southampton General Hospital, Southampton SO16 6YD
    BMJ 328:987. 2004
  86. ncbi Hepatitis G virus RNA is common in AIDS patients' plasma but is not associated with abnormal liver function tests or other clinical syndromes
    I Woolley
    Division of Infectious Diseases, University Hospitals of Cleveland, Center for AIDS Research, Case Western Reserve University, Ohio 44106 5083, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 19:408-12. 1998
    ..7; 95% confidence interval [CI], 2.4-25.0) but hepatitis C antibody was not. Mean values for liver function tests and hematologic values did not differ significantly between the groups nor did the occurrence of certain ..
  87. ncbi A case of elevated liver function tests after crown-of-thorns (Acanthaster planci) envenomation
    Brian Lin
    Stanford University Medical Center, Palo Alto, CA, USA
    Wilderness Environ Med 19:275-9. 2008
    ..We describe elevated liver enzymes in a 19-year-old female associated with A planci spine puncture wounds. To our knowledge, this is the first documented report of transaminitis in a human after A planci envenomation...
  88. ncbi Serum phenylalanine concentration as a marker of liver function in obese patients before and after bariatric surgery
    Julian Swierczynski
    Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80 241, Gdansk, Poland
    Obes Surg 19:883-9. 2009
    ..This study examines whether improvements of liver function after bariatric surgery is associated with a decrease of serum phenylalanine concentration caused by an increase of phenylalanine metabolism...
  89. ncbi Use of middle hepatic vein in right lobe living donor liver transplantation
    Murat Dayangac
    Florence Nightingale Hospital, Center for Organ Transplantation, Abide i Hurriyet Caddesi No 290 Sisli, Istanbul, Turkey
    Transpl Int 23:285-91. 2010
    ..The decision, therefore, of the extent of right lobe donor hepatectomy should be tailored to the particular conditions considering the graft quality and metabolic demand of the recipient...
  90. ncbi Association between serum prostate-specific antigen level, liver function tests and lipid profile in healthy men
    June Hyun Han
    Department of Urology, Hanil General Hospital, KEPCA Medical Foundation, Seoul, Korea
    BJU Int 102:1097-101. 2008
    To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-..
  91. ncbi Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 6:231-47. 2003
    ..administration of different concentrations of honey and their effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride (CCl(4))-induced liver damage were studied...
  92. ncbi Long-term cyclosporine treatment: evaluation of serum biochemical parameters and histopathological alterations in Wistar rats
    Ana Elisa Böhmer
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
    Exp Toxicol Pathol 63:119-23. 2011
    ..These results suggest that the CsA concentrations administered in our experimental protocol were able to induce immunosuppression in rats without causing nephro and hepatotoxicity...
  93. pmc Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE)
    Peter T Donnan
    Tayside Centre for General Practice, Community Health Sciences, University of Dundee, Dundee, UK
    BMC Health Serv Res 7:54. 2007
    b>Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations...
  94. ncbi Liver enzyme alterations after laparoscopic cholecystectomy
    H Erhan Guven
    3rd General Surgery Department, Ankara Oncology Research and Training Hospital, Demetevler Ankara, Turkey, 91 6 06500 Y Bahçelievler, Ankara, Turkey
    J Gastrointestin Liver Dis 16:391-4. 2007
    ....
  95. ncbi Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii
    Amy C Brown
    Department of Complementary and Alternative Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Clin Toxicol (Phila) 45:549-56. 2007
    To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu).
  96. ncbi Transient liver dysfunction after laparoscopic gastrectomy for gastric cancer patients
    Tsuyoshi Etoh
    Department of Surgery I, Oita University Faculty of Medicine, 1 1 Hasama machi, Oita, 879 5593, Japan
    World J Surg 31:1115-20. 2007
    ..The aim of this study was to clarify whether laparoscopy-assisted distal gastrectomy (LADG) is associated with changes in liver function compared with open distal gastrectomy (ODG)...
  97. ncbi Measurement of liver function for patients with cirrhosis by 13C-methacetin breath test compared with Child-Pugh score and routine liver function tests
    Yun Xiang Liu
    Department of Gastroenterology, Yantai Yuhuangding Hospital, Affiliated to Medical College of Qingdao University, Yantai 264000, China
    Chin Med J (Engl) 119:1563-6. 2006
  98. ncbi Assessment of hepatic reserve for the indication of hepatic resection: how I do it
    Gian Massimo Gazzaniga
    Department of Surgery, HPB Unit, Galliera Hospital Genova, Via A Volta 1, 16100 Genoa, Italy
    J Hepatobiliary Pancreat Surg 12:27-30. 2005
    ..However, a good multifactorial system that combines several elements (clinical, laboratory, functional, and volumetric evaluation) does provide sufficient data for determining the safe limits of hepatectomy...
  99. ncbi Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients
    Chien Wei Su
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Gastroenterology 130:1625-35. 2006
    ..Genotypes and viremia of hepatitis D virus (HDV) and hepatitis B virus (HBV) may be associated with outcomes. This study evaluated the impact of viral genotypes and viremia on outcomes of dual HBV and HDV infection...
  100. ncbi Motion - all patients with NASH need to have a liver biopsy: arguments for the motion
    Jayant A Talwalkar
    Mayo Clinic and Foundation, Rochester 55902, USA
    Can J Gastroenterol 16:718-21. 2002
    ..Only histological examination can establish the diagnosis of NASH, grade its severity, determine the prognosis and guide treatment...
  101. ncbi [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity]
    Sonia Chavarría-Arciniega
    Clínica de Obesidad del Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
    Rev Invest Clin 57:505-12. 2005
    ..Hepatic biochemical test are abnormal. Despite the lack of its own morphological characteristics, NASH can be differentiated from other pathologies, the gold standard for diagnosis is liver biopsy...

Research Grants62

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..b>Liver function tests are obtained every 3 months and if elevated, patients are again screened for hepatitis B, C, and A;CMV, EBV,..
  2. A rational approach to liver toxicity monitoring in methotrexate users
    Gabriela Schmajuk; Fiscal Year: 2013
    ..In the case of methotrexate, new NQF measures require testing of liver function tests (LFTs) every 12 weeks with the intent of reducing the incidence of hepatic fibrosis and cirrhosis...
  3. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..given to hepatitis B (HB) chronically infected pregnant women with a positive HBeAg test and normal liver function tests, from 28 weeks'gestation until two months postpartum to prevent perinatal transmission of hepatitis B ..
  4. VitaminA and Sickle Cell Disease:Improving Suboptimal Status with Supplementation
    KELLY ANN DOUGHERTY; Fiscal Year: 2013
    ..The key safety measures are concurrently elevated serum retinol (age specific) and liver function tests (3x age specific)...
  5. Hepatitis C Clinical Trial-Clinical Center
    Jules L Dienstag; Fiscal Year: 2009
    ..studies;studies of predictors of disease progression including fatty liver, obesity, diabetes, quantitative liver function tests, serum fibrosis markers, esophageal varices, dietary constituents including coffee and caffeine, health ..
  6. New treatment for androgen sensitive and resistant prostate cancer
    Angela M Brodie; Fiscal Year: 2013
    ..It has also been shown that rats exhibit no safety signal (blood cells, blood chemistries, liver function tests) after 28 days of daily oral dosing at levels up to and including 2000 mg/kg day...
  7. MULTICENTER AIDS COHORT STUDY
    Charles R Rinaldo; Fiscal Year: 2013
    ..Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies...
  8. Instrumentation for Creating Biological Stents and Occlusions
    FRED STERZER; Fiscal Year: 2011
    ..Gross and histological examinations, as well as liver function tests and imaging will be performed to determine optimum treatment parameters...
  9. SELECTIVE PLASMA EXCHANGE THERAPY
    Jacek Rozga; Fiscal Year: 2003
    ..Survival time and changes in intracranial pressure, cerebral perfusion pressure, and standard liver function tests will be examined...
  10. BLOOD COAGULATION AND HEMORRHAGIC DISEASE
    Jessica Lewis; Fiscal Year: 1980
    ..Liver biopsies have been done in about 20 individuals with abnormal liver function tests. Pathology has varied from chronic persistent hepatitis to chronic active hepatitis and cirrhosis...
  11. DIAGNOSTIC TEST TO EVALUATE IRRITABLE BOWEL SYNDROME
    BRIAN CRAINE; Fiscal Year: 1999
    ..obligating the patient to undergo a series of expensive tests such as endoscopy, complete blood counts, liver function tests, serum electrolytes, erythrocyte sedimentation rate, urine analysis, stool cultures and X-ray studies...
  12. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..NAFLD), which is associated with the metabolic syndrome, now represents the most common cause of abnormal liver function tests. "Thrifty genes" are genes that may have conferred a survival advantage to humans thousands of years ago, ..
  13. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    ..In a pilot study of anti-retroviral therapy with Combivir, 40% of patients completely normalized their liver function tests and there was a significant reversal of ductopenia on liver biopsy...
  14. Tumor Neovasculature Vector Targeting
    Albert Deisseroth; Fiscal Year: 2003
    ..will be monitored by a panel of tests during and after treatment, including several types of blood and liver function tests. Efficacy will be monitored by measurements of injected skin tumors, and also of skin tumors and internal ..
  15. Alcohol Associated Outcomes Among HIV+/-Aging Veterans
    Amy Justice; Fiscal Year: 2002
    ..Follow Back will be self completed by all patients and validated by interview in a subset, and additional liver function tests will be analyzed on banked specimens (CDT, GGT, ALT, and AST)...
  16. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2005
    ..Design: Obese Hispanic children and their nonobese siblings will be screened for NAFLD using serum liver function tests; total sample size will be 1000...
  17. HIV-Infected Patients' Experiences with HCV Treatment
    Carol Bova; Fiscal Year: 2003
    ..data (HCV treatment adherence, HIV RNA, HCV RNA, HCV genotype, liver pathology, complete blood counts, liver function tests, HIV illness stage and co-treatment with antiretroviral agents)...
  18. Epidemiology of HCV Infection among Egyptian Children
    Gamal Esmat; Fiscal Year: 2006
    ..assess liver function and morbidity in HCV infected children and their controls with clinical examinations, liver function tests, and abdominal ultrasound...
  19. Murine models of non-alcoholic steatohepatitis
    Alexander Igolnikov; Fiscal Year: 2005
    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the United States...
  20. A 13C-AMINO ACID BREATH TEST MEASURING LIVER FUNCTION
    David Wagner; Fiscal Year: 1992
    Biochemical liver function tests have been used by physicians in the identification and management of liver disease. These static tests include measurements of albumin, bilirubin, enzymes and prothrombin time...
  21. BEH PHARM TREATMENTS FOR ALCOHOL/NICOTINE DEPENDENCE
    Joy Schmitz; Fiscal Year: 2001
    ..Alcohol consumption will be measured by self-report, breath alcohol readings, collateral reports, and liver function tests. Primary efficacy parameters for drinking and smoking will include time to lapse/relapse and cumulative ..
  22. INTENSIVE CASE MANAGEMENT FOR CHRONIC PUBLIC INEBRIATES
    Gary Cox; Fiscal Year: 1992
    ..All subjects will be interviewed, and have blood samples drawn for liver function tests, at admission and at 6 month follow-up periods for two years...
  23. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2006
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  24. Fish oil & alpha lipoic acid in mild Alzheimer's disease
    Lynne Shinto; Fiscal Year: 2004
    ..treatment safety by a monthly monitoring of adverse events and laboratory tests (metabolic panel, including liver function tests and platelet function assay)...
  25. EVP-ABD Enhanced MRI for Evaluation Liver Disease
    PETER SEOANE; Fiscal Year: 2006
    ..While initial diagnosis of hepatitis may rely on medical history, Liver Function Tests (LFT), Polymerase Chain Reaction (PCR) results, etc...
  26. VARIATION IN THE EFFECTS OF ALCOHOL ON LIVER FUNCTION
    John Whitfield; Fiscal Year: 2007
    ..risk factors affect the probability of liver dysfunction in hazardous drinkers, using biochemical liver function tests to detect pre-clinical liver damage...
  27. Quality of Follow-up Care for Breast Cancer Survivors
    ANN NATTINGER; Fiscal Year: 2006
    ..Describe patterns of surveillance testing (mammograms, chest radiographs, bone scans, CT scans, liver function tests) among older breast cancer survivors, and among age-matched control subjects. 2...
  28. NALMEFENE IN NICOTINE AND ALCOHOL DEPENDENCE
    Barbara Mason; Fiscal Year: 2000
    ..interviews, expired air carbon monoxide and breath alcohol levels, plasma nicotine/cotinine assays, liver function tests, and urine toxicology screens...
  29. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  30. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  31. Oral Androgen Administration and Function in Man
    JOHN AMORY; Fiscal Year: 2008
    ..Matsumoto M.D., Director, Clinical Research Unit VA-Puget Sound and Professor of Medicine, University of Washington School of Medicine will co-mentor this award. [unreadable] [unreadable]..
  32. HCV-HIV Coinfection: Impact of Immune Dysfunction
    Richard Sterling; Fiscal Year: 2007
    ..The K-23 award will protect this candidates time and help him mature into a senior investigator in Hepatology. ..
  33. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2008
    ..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. [unreadable] [unreadable]..
  34. Racial Disparities in Diabetes in the US and the UK
    Arch Mainous; Fiscal Year: 2005
    ..abstract_text> ..
  35. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  36. WORLD REFERENCE CENTER FOR ARBOVIRUSES
    Robert Tesh; Fiscal Year: 2002
    ..abstract_text> ..
  37. Complications of Cirrhosis in American Patients
    Jorge Marrero; Fiscal Year: 2008
    ..I will supervise the conduct of the proposed research and meet with my mentors and advisors regularly. Completing this proposal will allow me to achieve my career goal and to contribute to an improve outcome of patients with HCC. ..
  38. Early Detection and Prognosis of Patients with Hepatocellular Carcinoma
    Jorge Marrero; Fiscal Year: 2008
    ..Therefore, identifying the risk factors, identifying new methods for early detection and determining prognosis for this tumor is of extreme importance. [unreadable] [unreadable]..
  39. HCV-ALCOHOL INTERACTIONS-- PATHOGENESIS AND EPIDEMIOLOGY
    Jack Stapleton; Fiscal Year: 2001
    ..These studies may lead to insights on the mechanism of liver injury and help define those patients who are most likely to have progressive liver injury. ..
  40. APPROACHES TO BRAIN TUMOR THERAPY
    Steven Brem; Fiscal Year: 2002
    ....
  41. SAMe Inhibits Inflammatory-mediated Enhanced Toxicity
    JANE MADDOX; Fiscal Year: 2003
    ..Moreover, they may provide evidence for development of related therapeutic compounds. ..
  42. Naltrexone Treatment in Pathologic Gambling Disorder
    SUCK KIM; Fiscal Year: 2004
    ..S. The implications of our study expand from PGD to other impulse control disorders, including compulsive shopping, kleptomania and possible alcoholism. ..
  43. Improving Transfusion Practices Using Decision Support
    Jeffrey Rothschild; Fiscal Year: 2004
    ..We will also examine whether improvements in appropriate transfusion ordering behavior among clinicians using decision support tools will be greater than improvements achieved by educational programs alone. ..
  44. SAW PALMETTO EXTRACT IN BENIGN PROSTATIC HYPERPLASIA
    Andrew Avins; Fiscal Year: 2003
    ..Numerous laboratory parameters will measured at intervals throughout the trial and symptomatic side effects will be assessed. ..
  45. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  46. IMPROVING POSTTREATMENT ALCOHOLICS ANONYMOUS UTILIZATION
    Richard Cloud; Fiscal Year: 2005
    ..abstract_text> ..
  47. Effects of Smoked Heroin Across the Menstrual Cycle
    Suzette Evans; Fiscal Year: 2005
    ..The proposed studies will be the first to systematically evaluate these effects in female non-human primates. ..
  48. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  49. INTERLEUKIN 6 AND HUMAN BILIARY EPITHELIAL PROLIFERATION
    Anthony Demetris; Fiscal Year: 2006
    ..abstract_text> ..
  50. Assessment of BBB Disruption during RT using DCE MRI
    Yue Cao; Fiscal Year: 2006
    ..Data from these scans will be analyzed to quantify vascular permeability, which related to dose, volume, time, and presence in tumor versus normal brain tissue. ..
  51. In Vivo Evaluation of Myocardial Lipids
    LIDIA SZCZEPANIAK; Fiscal Year: 2006
    ..In contrast, I predict that functional cardiac abnormalities will be unaffected when diabetic subjects are treated with sulfonylureases that have no effect on PPAR-gamma. ..
  52. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2007
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. [unreadable] [unreadable]..
  53. Regulation of Stellate Cell Contractility
    Don Rockey; Fiscal Year: 2008
    ..Physiologic endpoints will be an important focus. The proposed studies will shed light on the molecular basis of stellate cell contractility and moreover have direct relevance to human liver disease. ..
  54. REGULATION OF PURINE NUCLEOTIDE SYNTHESIS IN HUMANS
    Michael Becker; Fiscal Year: 2001
    ....