- Histological changes in the liver of morbidly obese patients: correlation with metabolic parameters
Anna Maria Wolf
Department of Visceral and Transplantation Surgery, University Hospital Ulm, Germany
Obes Surg 15:228-37. 2005
- Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
Department of Medicine, Karolinska Institute, Solna, Stockholm, Sweden
Hepatology 51:595-602. 2010
..69; 95% confidence interval [CI], 1.24-2.25); subjects with bland steatosis, a 55% increase (SMR, 1.55; 95% CI, 0.98-2.32; P = 0.062); and subjects with NASH, 86% (SMR, 1.86; 95% CI, 1.19-2.76; P = 0.007)...
- Evaluation of abnormal liver function tests
J K Limdi
Tameside General Hospital, Ashton under Lyne, Manchester, UK
Postgrad Med J 79:307-12. 2003
Interpretation of abnormalities in liver function tests is a common problem faced by clinicians. This has become more common with the introduction of automated routine laboratory testing...
- Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort
Matthew J Armstrong
Centre for Liver Research, NIHR Liver Biomedical Research Unit, University of Birmingham, UK
J Hepatol 56:234-40. 2012
..This study seeks to calculate the range of disease severity of NAFLD in a primary care setting...
- AGA technical review on the evaluation of liver chemistry tests
Richard M Green
Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Gastroenterology 123:1367-84. 2002
- Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program
Larry A Allen
Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
Eur J Heart Fail 11:170-7. 2009
..The prevalence and importance of liver function test (LFT) abnormalities in a large contemporary cohort of heart failure patients have not been systematically evaluated...
- Autoimmune hepatitis
Edward L Krawitt
Department of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
N Engl J Med 354:54-66. 2006
- Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial
Andrew P Ambrosy
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Eur J Heart Fail 14:302-11. 2012
Abnormal liver function tests (LFTs) are common in ambulatory heart failure (HF). The aim of this study was to characterize abnormal LFTs during index hospitalization.
- 13C-breath tests: current state of the art and future directions
John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
Dig Liver Dis 39:795-805. 2007
..The stable isotope technique presents an elegant, non-invasive diagnostic tool promising further options of clinical applications. This review is aimed at providing an overview on the relevant clinical applications of 13C-breath tests...
- The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients
Department of Surgery and Interdisciplinary Obesity Study Group, University of South Florida Health Sciences Center, Tampa, FL 33601, USA
Obes Surg 14:54-9. 2004
..Prevalence of NASH in bariatric patients is unknown. Our aim was to determine the role of routine liver biopsy in managing bariatric patients...
- High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis
Keith D Lindor
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Hepatology 50:808-14. 2009
..01) and 2.1 times greater for death, transplantation, or minimal listing criteria (P = 0.038). Serious adverse events were more common in the UDCA group than the placebo group (63% versus 37% [P < 0.01])...
- Safety and efficacy of nevirapine- and efavirenz-based antiretroviral treatment in adults treated for TB-HIV co-infection in Botswana
L K Shipton
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 13:360-6. 2009
..The safety and efficacy of nevirapine (NVP) and efavirenz (EFV) based highly active antiretroviral treatment (ART) with concurrent anti-tuberculosis treatment in sub-Saharan Africa has not been well established...
- Evidence-based incorporation of serum sodium concentration into MELD
Scott W Biggins
University of California San Francisco, San Francisco, California, USA
Gastroenterology 130:1652-60. 2006
..Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation...
- Liver enzyme alteration: a guide for clinicians
Edoardo G Giannini
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
CMAJ 172:367-79. 2005
- Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring
D R Dufour
Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
Clin Chem 46:2050-68. 2000
..To review information on the use of laboratory tests in screening, diagnosis, and monitoring of acute and chronic hepatic injury...
- Noninvasive measures of liver fibrosis
Don C Rockey
Department of Medicine, and the Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Hepatology 43:S113-20. 2006
..The development of safe, inexpensive, and reliable noninvasive fibrosis measurement tools remains a research priority in clinical hepatology...
- Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study
Department of Clinical Biochemistry, Odense University Hospital, DK 5000 Odense C, Denmark
Clin Chem 47:81-7. 2001
Biochemical liver function tests are widely used in the clinic and are some of the most frequently used tests in screening for diseases in older age groups...
- Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town
Gaspare Maria Pendino
Divisione di Medicina 1, Policlinico Madonna della Consolazione, Reggio Calabria, Italy
Hepatology 41:1151-9. 2005
- Measuring markers of liver function using a micropatterned paper device designed for blood from a fingerstick
Sarah J Vella
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States
Anal Chem 84:2883-91. 2012
..This device illustrates a type of test useable for a range of assays in resource-poor settings...
- The prognostic role of WHO classification, urinary 5-hydroxyindoleacetic acid and liver function tests in metastatic neuroendocrine carcinomas of the gastroenteropancreatic tract
Department of Medicine, Royal Marsden Hospital, London and Sutton, Surrey, UK
Br J Cancer 96:1178-82. 2007
..In a WDNEC-restricted analysis, abnormal liver function tests (LFTs) and elevated urinary 5-hydroxyindoleacetic acid (u5HIAA) were independent prognostic factors for ..
- Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure
Department of Cardio angiology, Kitasato University School of Medicine, Sagamihara, Japan
Circ J 72:364-9. 2008
The aim of this study was to analyze the relationship between abnormal liver function tests (LFTs) coincident with heart failure (HF) exacerbation and subsequent long-term outcome in patients with chronic HF.
- Hepatocellular necrosis, apoptosis, and proliferation after transcatheter arterial embolization or chemoembolization in a standardized rabbit model
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie fang Rd, Wuhan 430022, China
J Vasc Interv Radiol 22:1606-12. 2011
..To evaluate the effect of transcatheter arterial chemoembolization versus transcatheter arterial embolization on hepatocellular damage, apoptosis, proliferation, and proinflammatory response in a rabbit VX2 tumor model...
- The utility of liver function tests for mortality prediction within one year in primary care using the algorithm for liver function investigations (ALFI)
David J McLernon
Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
PLoS ONE 7:e50965. 2012
Although liver function tests (LFTs) are routinely measured in primary care, raised levels in patients with no obvious liver disease may trigger a range of subsequent expensive and unnecessary management plans...
- Muscular exercise can cause highly pathological liver function tests in healthy men
AstraZeneca R and D Lund, Lund, Sweden
Br J Clin Pharmacol 65:253-9. 2008
..Physical exercise can result in transient elevations of liver function tests. There is no consensus in the literature on which forms of exercise may cause changes in liver function ..
- Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows
Felix Diaz González
Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Vet Sci 12:251-5. 2011
..During early lactation, 30% of cows suffered hepatic lipidosis as detected by levels of AST. Compromised hepatic function was observed in early lactation cows as shown by lower concentrations of glucose, total protein, and urea...
- Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
Am J Gastroenterol 103:2263-71. 2008
..The current study compared the survival of subjects with and without suspected NAFLD in a population-based cohort, and placed the finding in the context of previously published case series...
- Prognostic value of indocyanine green elimination assessed with LiMON in septic patients
Mehmet Turan Inal
Department of Anesthesiology, Trakya University Medical Faculty, 22030 Edirne, Turkey
J Crit Care 24:329-34. 2009
..Sepsis is the most frequent infection with high mortality rates in intensive care units (ICUs), and the prediction of outcome is important in the decision-making process...
- Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection
Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
Am J Gastroenterol 103:1136-44. 2008
..We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV)...
- Postoperative changes in liver function tests: randomized comparison of low- and high-pressure laparoscopic cholecystectomy
Department of Surgery, University Clinical Center Tuzla, Faculty of Medicine, University of Tuzla, Trnovac b b, 75, 000, Tuzla, Bosnia Herzegovina
Surg Endosc 19:1451-5. 2005
..This study evaluated the changes in liver function tests after high-pressure LC (HPLC; 14 mmHg) and low-pressure LC (LPLC; 7 mmHg).
- Independent prospective multicenter validation of biochemical markers (fibrotest-actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C: the fibropaca study
Department of Virology, Alphabio Laboratory, 23 Street of Friedland, 13006 Marseille, France
Am J Gastroenterol 101:547-55. 2006
..The aim of this study was to perform an external validation of FT and AT and to study the discordances between FT/AT and liver biopsy in patients with chronic hepatitis C...
- Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B
Department of Medicine, Toronto General Hospital, Toronto, Ontario, Canada
Gastroenterology 130:2039-49. 2006
..In preclinical and phase II studies, entecavir demonstrated potent antiviral activity against lamivudine-resistant HBV...
- Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats
Gene T Yocum
Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Radiology 235:547-52. 2005
- Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients
Chung Bao Hsieh
Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China
World J Gastroenterol 10:2394-6. 2004
..To investigate whether the non-invasive real-time Indocyanine green (ICG) clearance is a sensitive index of liver viability in patients before, during, and after liver transplantation...
- A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid
V N Santos
Disciplina de Gastroenterologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
Braz J Med Biol Res 36:723-9. 2003
..These results show that ursodeoxycholic acid is able to reduce serum levels of hepatic enzymes in patients with nonalcoholic fatty liver disease, but this effect is not related to modifications in liver fat content...
- Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men
Sasiwarang Goya Wannamethee
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, U K
Diabetes Care 28:2913-8. 2005
..We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk...
- The association of alanine transaminase with aging, frailty, and mortality
David G Le Couteur
Centre for Education and Research on Ageing, Concord RG Hospital, University of Sydney, Hospital Road, Concord, NSW 2139, Australia
J Gerontol A Biol Sci Med Sci 65:712-7. 2010
..Low ALT activity is a predictor of reduced survival; however, this seems to be mediated by its association with frailty and increasing age. ALT has potential value as a novel biomarker of aging...
- Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests
D R Dufour
Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
Clin Chem 46:2027-49. 2000
..To review information on performance characteristics for tests that are commonly used to identify acute and chronic hepatic injury...
- [13C]-Galactose breath test: correlation with liver fibrosis in chronic hepatitis C
Fédération des spécialités digestives, Hopital E Herriot, Lyon, France
Eur J Clin Invest 29:624-9. 1999
..However, this test lacks sensitivity in early liver disease. The goal of this study was to evaluate a [13C]-galactose breath test (GBT) in a population of patients with chronic hepatitis C...
- Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virus-infected patients treated for non-Hodgkin lymphoma
Blood 99:724-5. 2002
- Prevalence of hepatitis B and C seromarkers and abnormal liver function tests among hemophiliacs in Guilan (northern province of Iran)
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Med Sci Monit 8:CR797-800. 2002
The aim of this study was to determine the seroprevalence of hepatitis B and C viruses and abnormal liver function tests among hemophiliacs in Guilan province, Iran.
- Adiponectin, hepatocellular dysfunction and insulin sensitivity
Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain
Clin Endocrinol (Oxf) 60:256-63. 2004
- Liver function tests and their interpretation
B R Thapa
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Indian J Pediatr 74:663-71. 2007
b>Liver function tests (LFT) are a helpful screening tool, which are an effective modality to detect hepatic dysfunction...
- Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral therapy
Unit of Infectious Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, Barcelona, Spain
AIDS 15:1261-8. 2001
..To assess the incidence and risk factors for hepatotoxicity associated with nevirapine...
- Pretreatment of male BALB/c mice with beta-ionone potentiates thioacetamide-induced hepatotoxicity
T C Jeong
Toxicology Research Center, Korea Research Institute of Chemical Technology, Taejon, South Korea
Toxicol Lett 105:39-46. 1999
..our present results suggest that beta-ionone may be a useful model inducer of P450 enzyme(s) in studying toxic mechanism of certain chemicals which require metabolic activation by P450s in mice...
- Review article: the assessment of liver function using breath tests
Liver Unit, Department of Medicine, Hebrew University, Hadassah Medical Center, Jerusalem, Israel
Aliment Pharmacol Ther 26:1293-302. 2007
..The recent development of a real-time, point-of-care liver function breath test has made it straightforward to assess the metabolic function of the liver...
- Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation
Ming Huan Shyu
Department of Food Science and Biotechnology, National Chung Hsing University, 250, Kuokuang Road, Taiching 402, Taiwan
Food Chem Toxicol 46:3707-13. 2008
..Taken together, our data indicate that EHT can efficiently inhibit CCl(4)-induced liver fibrosis in rats. EHT may therefore be a useful functional food for preventing liver fibrosis...
- A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients
Guilherme M Campos
Department of Surgery, University of California San Francisco, San Francisco, CA 94143 0790, USA
Hepatology 47:1916-23. 2008
..3; 95% CI, 1.4-8.0), and non-Black race (OR, 8.4; 95% CI, 1.9-37.1). A NASH Clinical Scoring System for Morbid Obesity was derived to predict the probability of NASH in four categories (low, intermediate, high, and very high)...
- Health outcomes following liver function testing in primary care: a retrospective cohort study
David J McLernon
Medical Statistics Team, Section of Population Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
Fam Pract 26:251-9. 2009
patients who present with abnormal liver function tests (LFTs) in primary care and no obvious symptoms can be difficult to manage.
- Epidemiology and genetic epidemiology of the liver function test proteins
Department of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom
PLoS ONE 4:e4435. 2009
..The liver function test (LFT) is among the most commonly used clinical investigations to assess hepatic function, severity of liver diseases and the effect of therapies, as well as to detect drug-induced liver injury (DILI)...
- Brief communication: clinical implications of short-term variability in liver function test results
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205 2223, USA
Ann Intern Med 148:348-52. 2008
..Clinicians sometimes order liver tests as part of a screening examination or general work-up. Current guidelines do not recommend routine retesting of abnormal results in asymptomatic patients...
- Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities
Michael D McGoon
Mayo Clinic, Rochester, MN 55905, USA
Chest 135:122-9. 2009
..Because ambrisentan may provide benefits in PAH patients who have discontinued ERA therapy due to LFT abnormalities, we evaluated the safety and efficacy of ambrisentan in this patient population...
- Elevation of liver function tests in severe anorexia nervosa
R Hill Harris
Department of Medicine, Denver Health Medical Center, Denver, Colorado 80204, USA
Int J Eat Disord 46:369-74. 2013
..The purpose of this article is to clarify the finding of liver function test abnormalities in anorexia nervosa (AN)...
- Evaluation of liver fibrosis: a concise review
Nezam H Afdhal
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
Am J Gastroenterol 99:1160-74. 2004
..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
- Liver function tests in patients with acute heart failure
Centre for Heart Diseases, 4th Military Hospital, Wrocław, Poland
Pol Arch Med Wewn 122:471-9. 2012
..Acute heart failure (AHF) is associated with multiorgan dysfunction, which may unfavorably affect prognosis...
- Elevation of liver function tests after laparoscopic gastrectomy using a Nathanson liver retractor
Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
World J Surg 35:2730-8. 2011
Although pneumoperitoneum has been suspected as a possible cause of transient elevation of liver function tests (LFTs) after laparoscopic surgery, liver damage by direct retraction could also influence postoperative LFTs...
- Liver function tests and risk prediction of incident type 2 diabetes: evaluation in two independent cohorts
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
PLoS ONE 7:e51496. 2012
b>Liver function tests might predict the risk of type 2 diabetes. An independent study evaluating utility of these markers compared with an existing prediction model is yet lacking.
- The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit
Pfizer Global Research and Development, Pfizer Ltd, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
Br J Clin Pharmacol 57:199-208. 2004
To investigate the effect of diet upon liver function tests and serum lipids within the restricted environment of a Phase I unit.
- Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh
Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh
Environ Health 10:64. 2011
..However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented...
- Non ominous changes in liver function tests after laparoscopic cholecystectomy
Alan A Saber
J Gastrointestin Liver Dis 16:427-8. 2007
- Predicting liver failure following major hepatectomy
Department of Hepatobiliary and Upper Gastrointestinal Surgery, The Queen Elizabeth Hospital, Adelaide, SA 5011, Australia
Dig Liver Dis 41:798-806. 2009
..Published data would not suggest any difference in mortality, morbidity or liver failure rates between these groups. This review outlines and presents the evidence for pre-operative quantification of functional liver remnant volume...
- Hepatic changes in the failing Fontan circulation
Christoph H Kiesewetter
Southampton General Hospital, University Hospitals Southampton, Southampton, UK
Heart 93:579-84. 2007
..The failing Fontan circulation is associated with hepatic impairment. The nature of this liver injury is poorly defined...
- Could quantitative liver function tests gain wide acceptance among hepatologists?
World J Gastroenterol 15:3457-61. 2009
..Furthermore, who are the operators that should order these tests? Advances in analytic methods are expected to allow quantitative liver function tests to be used in clinical practice.
- Coagulation dynamics and platelet functions in obstructive jaundiced patients
Marmara University School of Medicine, Department of General Surgery, Istanbul, Turkey
J Gastroenterol Hepatol 24:748-51. 2009
..All of the body systems are affected by increased levels of bilirubin. The aim of this study is to investigate the function of platelets and clotting dynamics in patients with obstructive jaundice...
- The asymptomatic outpatient with abnormal liver function tests
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 750 Welch Road, Suite 210, Stanford, CA 94304, USA
Clin Liver Dis 13:167-77. 2009
..and hepatic synthetic measures (prothrombin time (PT) and serum albumin level) are referred to as liver function tests (LFTs)...
- Anicteric cholangiopathy in schistosomiasis patients
Paulo Eugenio Brant
Department of Medicine, Universidade Federal de Sao Paulo, Rua Jabuticabeiras 807, 05674 011 São Paulo, Brazil
Acta Trop 108:218-21. 2008
..We now describe the presence of cholangiopathy in these patients...
- Acoustic radiation force impulse elastography for chronic liver disease: comparison with ultrasound-based scores of experienced radiologists, Child-Pugh scores and liver function tests
Ji Eun Kim
Department of Radiology, Seoul National University Hospital, Seoul, Korea
Ultrasound Med Biol 36:1637-43. 2010
..performance for diagnosis of chronic liver disease and correlates better with Child-Pugh scores and liver function tests, compared with an ultrasound (US) scoring system based on visual assessment of conventional B-mode US ..
- Should patients with abnormal liver function tests in primary care be tested for chronic viral hepatitis: cost minimisation analysis based on a comprehensively tested cohort
David T Arnold
School of Medicine, Cardiff University, Cardiff, UK
BMC Fam Pract 12:9. 2011
b>Liver function tests (LFTs) are ordered in large numbers in primary care, and the Birmingham and Lambeth Liver Evaluation Testing Strategies (BALLETS) study was set up to assess their usefulness in patients with no pre-existing or self-..
- Effects of varying intraperitoneal pressure on liver function tests during laparoscopic cholecystectomy
Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India
J Laparoendosc Adv Surg Tech A 23:339-42. 2013
..The use of low-pressure pneumoperitoneum in the range of 8-10 mm Hg has been shown to reduce the adverse physiological changes without affecting the outcome of surgery...
- "Liver function tests" are not always tests of liver function
D N Korones
Department of Pediatrics, University of Rochester, School of Medicine and Dentistry, Children s Hospital at Strong, New York 14642, USA
Am J Hematol 66:46-8. 2001
..Hematologists/oncologists should consider obtaining a serum CK to rule out muscle disease in patients with unexplained elevations of AST, ALT, and LDH...
- Nuclear imaging techniques for the assessment of hepatic function in liver surgery and transplantation
Wilmar de Graaf
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
J Nucl Med 51:742-52. 2010
..In liver transplantation, these methods are used to assess graft function and biliary complications...
- Noninvasive quantitative testing of liver function using ultrasonography in patients with cirrhosis
Guo Zhen Yan
Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
Hepatogastroenterology 53:15-20. 2006
- Background incidence of liver chemistry abnormalities in a clinical trial population without underlying liver disease
John G Weil
WW Epidemiology, Neurosciences and International Support, GlaxoSmithKline Research and Development Ltd, New Frontiers Science Park, South Third Avenue, Harlow, Essex CM19 5AW, UK
Regul Toxicol Pharmacol 52:85-8. 2008
..The study was undertaken to determine the background rates of liver chemistry abnormalities in clinical trial populations without underlying liver disease...
- Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
Thyroid 18:283-7. 2008
When the liver function tests are aggravated after starting antithyroid drugs (ATDs) in Graves' hyperthyroidism, discontinuation of ATDs is generally considered...
- Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure
N De Liguori Carino
Supra Regional Hepatobiliary Unit, University Hospital Aintree, Liverpool, L9 7AL, UK
Eur J Surg Oncol 35:957-62. 2009
..The aim was to assess the relationship between pre and post-operative ICG plasma disappearance rate (ICG PDR %/min) values and the onset of post-hepatectomy liver dysfunction...
- Living liver donor death related to complications of myeloma
Department of HPB Surgery and Liver Transplantation, Hospital Beaujon, Clichy, France
Liver Transpl 15:326-9. 2009
..This unusual cause of donor death after right hepatectomy reinforces the need for an extensive preoperative assessment. We advocate the addition of urinary protein loss and electrophoresis to the standard donor assessment protocol...
- Evaluation of ornithine carbamoyl transferase and other serum and liver-derived analytes in diagnosis of fatty liver and postsurgical outcome of left-displaced abomasum in dairy cows
Clinic of Farm Animals, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
J Am Vet Med Assoc 229:1463-71. 2006
- Perioperative outcome after laparoscopic radiofrequency ablation of liver tumors: an analysis of 521 cases
Department of General Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Surg Endosc 21:613-8. 2007
..Understanding the morbidity and laboratory changes after RFA is important for operative indications and perioperative management...
- Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study
Anthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Diabetes 53:2623-32. 2004
..In conclusion, AST and ALT independently predict type 2 diabetes. Baseline elevations of these markers may reflect NAFLD or related pathologies...
- Liver function tests: their role in the diagnosis of hepatobiliary diseases
Joseph A Knight
Division of Education at the Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
J Infus Nurs 28:108-17. 2005
..Although liver function tests are critical in recognizing the presence of liver disease and its specific diagnosis, the interpretation of ..
- Liver function tests and statins
Philippe J Zamor
Department of Medicine, Center for Liver Diseases and Transplantation, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
Curr Opin Cardiol 26:338-41. 2011
..To discuss recent data on statins in patients with elevated liver tests...
- Noninvasive assessment of liver fibrosis in patients with Fontan circulation using transient elastography and biochemical fibrosis markers
Department of Internal Medicine, JW Goethe University Clinic, Frankfurt, Germany
J Thorac Cardiovasc Surg 135:560-7. 2008
..Therefore, early detection of fibrosis is essential to identify patients at risk. Transient elastography has been evaluated for noninvasive staging of liver fibrosis in a multitude of studies...
- Hepatotoxic effects of therapies for tuberculosis
Bahaa E Senousy
Internal Medicine Department, Ain Shams University, Abbassia 11566, Cairo, Egypt
Nat Rev Gastroenterol Hepatol 7:543-56. 2010
- Simple clinical variables predict liver histology in hepatitis C: prospective validation of a clinical prediction model
Digestive Disease Center, University of South Carolina, 96 Jonathon Lucas Street, PO Box 250 327, Charleston, SC 29425, USA
Scand J Gastroenterol 40:1365-71. 2005
..Absence of predictors also predicted a lack of inflammation and fibrosis. Our aim was prospectively to validate this clinical prediction model using an independent multicenter sample...
- A novel cause for abnormal liver function tests in pregnancy and the puerperium: non-alcoholic fatty liver disease
L M Page
Department of Obstetrics and Gynaecology, West Middlesex University Hospital, Isleworth, UK
BJOG 118:1532-5. 2011
..We suggest that NAFLD should also be considered as a cause for abnormal liver function tests during pregnancy...
- Liver function tests: defining what's normal
Community Clinical Sciences Research Division, University of Southampton, B Floor, South Academic Block, Southampton General Hospital, Southampton SO16 6YD
BMJ 328:987. 2004
- Hepatitis G virus RNA is common in AIDS patients' plasma but is not associated with abnormal liver function tests or other clinical syndromes
Division of Infectious Diseases, University Hospitals of Cleveland, Center for AIDS Research, Case Western Reserve University, Ohio 44106 5083, USA
J Acquir Immune Defic Syndr Hum Retrovirol 19:408-12. 1998
..7; 95% confidence interval [CI], 2.4-25.0) but hepatitis C antibody was not. Mean values for liver function tests and hematologic values did not differ significantly between the groups nor did the occurrence of certain ..
- A case of elevated liver function tests after crown-of-thorns (Acanthaster planci) envenomation
Stanford University Medical Center, Palo Alto, CA, USA
Wilderness Environ Med 19:275-9. 2008
..We describe elevated liver enzymes in a 19-year-old female associated with A planci spine puncture wounds. To our knowledge, this is the first documented report of transaminitis in a human after A planci envenomation...
- Serum phenylalanine concentration as a marker of liver function in obese patients before and after bariatric surgery
Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80 241, Gdansk, Poland
Obes Surg 19:883-9. 2009
..This study examines whether improvements of liver function after bariatric surgery is associated with a decrease of serum phenylalanine concentration caused by an increase of phenylalanine metabolism...
- Use of middle hepatic vein in right lobe living donor liver transplantation
Florence Nightingale Hospital, Center for Organ Transplantation, Abide i Hurriyet Caddesi No 290 Sisli, Istanbul, Turkey
Transpl Int 23:285-91. 2010
..The decision, therefore, of the extent of right lobe donor hepatectomy should be tailored to the particular conditions considering the graft quality and metabolic demand of the recipient...
- Association between serum prostate-specific antigen level, liver function tests and lipid profile in healthy men
June Hyun Han
Department of Urology, Hanil General Hospital, KEPCA Medical Foundation, Seoul, Korea
BJU Int 102:1097-101. 2008
To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-..
- Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury
Noori S Al-Waili
Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
J Med Food 6:231-47. 2003
..administration of different concentrations of honey and their effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride (CCl(4))-induced liver damage were studied...
- Long-term cyclosporine treatment: evaluation of serum biochemical parameters and histopathological alterations in Wistar rats
Ana Elisa Böhmer
Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2600 Anexo, 90035 003 Porto Alegre, RS, Brazil
Exp Toxicol Pathol 63:119-23. 2011
..These results suggest that the CsA concentrations administered in our experimental protocol were able to induce immunosuppression in rats without causing nephro and hepatotoxicity...
- Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE)
Peter T Donnan
Tayside Centre for General Practice, Community Health Sciences, University of Dundee, Dundee, UK
BMC Health Serv Res 7:54. 2007
b>Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations...
- Liver enzyme alterations after laparoscopic cholecystectomy
H Erhan Guven
3rd General Surgery Department, Ankara Oncology Research and Training Hospital, Demetevler Ankara, Turkey, 91 6 06500 Y Bahçelievler, Ankara, Turkey
J Gastrointestin Liver Dis 16:391-4. 2007
- Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii
Amy C Brown
Department of Complementary and Alternative Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
Clin Toxicol (Phila) 45:549-56. 2007
To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu).
- Transient liver dysfunction after laparoscopic gastrectomy for gastric cancer patients
Department of Surgery I, Oita University Faculty of Medicine, 1 1 Hasama machi, Oita, 879 5593, Japan
World J Surg 31:1115-20. 2007
..The aim of this study was to clarify whether laparoscopy-assisted distal gastrectomy (LADG) is associated with changes in liver function compared with open distal gastrectomy (ODG)...
- Measurement of liver function for patients with cirrhosis by 13C-methacetin breath test compared with Child-Pugh score and routine liver function tests
Yun Xiang Liu
Department of Gastroenterology, Yantai Yuhuangding Hospital, Affiliated to Medical College of Qingdao University, Yantai 264000, China
Chin Med J (Engl) 119:1563-6. 2006
- Assessment of hepatic reserve for the indication of hepatic resection: how I do it
Gian Massimo Gazzaniga
Department of Surgery, HPB Unit, Galliera Hospital Genova, Via A Volta 1, 16100 Genoa, Italy
J Hepatobiliary Pancreat Surg 12:27-30. 2005
..However, a good multifactorial system that combines several elements (clinical, laboratory, functional, and volumetric evaluation) does provide sufficient data for determining the safe limits of hepatectomy...
- Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients
Chien Wei Su
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Gastroenterology 130:1625-35. 2006
..Genotypes and viremia of hepatitis D virus (HDV) and hepatitis B virus (HBV) may be associated with outcomes. This study evaluated the impact of viral genotypes and viremia on outcomes of dual HBV and HDV infection...
- Motion - all patients with NASH need to have a liver biopsy: arguments for the motion
Jayant A Talwalkar
Mayo Clinic and Foundation, Rochester 55902, USA
Can J Gastroenterol 16:718-21. 2002
..Only histological examination can establish the diagnosis of NASH, grade its severity, determine the prognosis and guide treatment...
- [Relationship between morphological diagnosis of NASH (non-alcoholic steatohepatitis) and liver function tests in a group of patients with morbid obesity]
Clínica de Obesidad del Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Rev Invest Clin 57:505-12. 2005
..Hepatic biochemical test are abnormal. Despite the lack of its own morphological characteristics, NASH can be differentiated from other pathologies, the gold standard for diagnosis is liver biopsy...