gastrointestinal transit

Summary

Summary: Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.

Top Publications

  1. ncbi Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation
    N Washington
    Division of Gastroenterology and Department of Surgery, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Clin Nutr 67:317-21. 1998
  2. ncbi Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    A Agrawal
    Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
    Aliment Pharmacol Ther 29:104-14. 2009
  3. ncbi A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome
    H J Kim
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 17:895-904. 2003
  4. ncbi Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 58:357-65. 2009
  5. ncbi Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility
    Nicolas T Schwarz
    Chirurgische Universitätsklinik der Friedrich Wilhelms Universität, Bonn, Germany
    Gastroenterology 126:159-69. 2004
  6. ncbi Etiology of portal hypertension may influence gastrointestinal transit
    R Sadik
    Division of Gastroenterology, Institute of Internal Medicine, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Scand J Gastroenterol 38:1039-44. 2003
  7. ncbi Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 29:315-28. 2009
  8. ncbi Prucalopride, a systemic enterokinetic, for the treatment of constipation
    A V Emmanuel
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1347-56. 2002
  9. ncbi Review article: bifidobacteria as probiotic agents -- physiological effects and clinical benefits
    C Picard
    Danone Vitapole, Centre de Recherche Daniel Carasso, Nutrivaleur, Palaiseau, France
    Aliment Pharmacol Ther 22:495-512. 2005
  10. ncbi Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract
    W P Charteris
    SET Consultants Ltd, Douglas, Cork, Ireland
    J Appl Microbiol 84:759-68. 1998

Research Grants

Detail Information

Publications247 found, 100 shown here

  1. ncbi Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation
    N Washington
    Division of Gastroenterology and Department of Surgery, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Clin Nutr 67:317-21. 1998
    ..05). Psyllium delays gastric emptying, probably by increasing meal viscosity, and reduces the acceleration of colon transit, possibly by delaying the production of gaseous fermentation products...
  2. ncbi Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    A Agrawal
    Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
    Aliment Pharmacol Ther 29:104-14. 2009
    ..A sensation of abdominal swelling (bloating) and actual increase in girth (distension) are troublesome features of irritable bowel syndrome (IBS), which is more common in patients with constipation, especially those with delayed transit...
  3. ncbi A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome
    H J Kim
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 17:895-904. 2003
    To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of patients with Rome II irritable bowel syndrome with predominant diarrhoea.
  4. ncbi Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 58:357-65. 2009
    ..To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT(4) receptor agonist, in patients with chronic constipation...
  5. ncbi Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility
    Nicolas T Schwarz
    Chirurgische Universitätsklinik der Friedrich Wilhelms Universität, Bonn, Germany
    Gastroenterology 126:159-69. 2004
    ..The current objective was to investigate pan-enteric inflammatory molecular and functional motility alterations of the muscularis from the unmanipulated stomach and colon initiated by selective jejunal manipulation...
  6. ncbi Etiology of portal hypertension may influence gastrointestinal transit
    R Sadik
    Division of Gastroenterology, Institute of Internal Medicine, Sahlgrenska University Hospital, University of Goteborg, Goteborg, Sweden
    Scand J Gastroenterol 38:1039-44. 2003
    b>Gastrointestinal transit studies have shown contradictory results in patients with portal hypertension. We have studied gastric emptying. small-bowel transit and colonic transit in patients with portal hypertension...
  7. ncbi Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 29:315-28. 2009
    ..Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL)...
  8. ncbi Prucalopride, a systemic enterokinetic, for the treatment of constipation
    A V Emmanuel
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1347-56. 2002
    ..Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis...
  9. ncbi Review article: bifidobacteria as probiotic agents -- physiological effects and clinical benefits
    C Picard
    Danone Vitapole, Centre de Recherche Daniel Carasso, Nutrivaleur, Palaiseau, France
    Aliment Pharmacol Ther 22:495-512. 2005
    ..Bifidobacteria may exert protective intestinal actions through various mechanisms, and represent promising advances in the fields of prophylaxis and therapy...
  10. ncbi Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract
    W P Charteris
    SET Consultants Ltd, Douglas, Cork, Ireland
    J Appl Microbiol 84:759-68. 1998
    An in vitro methodology which mimics in vivo human upper gastrointestinal transit was developed...
  11. ncbi Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro-cecal transit time
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 25:6-10. 2006
    ..Quantitative culture of upper gut aspirate is used as a gold standard for the diagnosis of SIBO. Studies on diagnosis of SIBO using non-invasive hydrogen breath tests are contradictory...
  12. ncbi Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus
    N T Schwarz
    Department of Medicine Gastroenterology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Gastroenterology 121:1354-71. 2001
    ..This study demonstrates a significant role for cyclooxygenase (COX)-2 and prostanoid production as mechanisms for surgically induced postoperative ileus...
  13. ncbi Hydrolysed protein accelerates the gastrointestinal transport of formula in preterm infants
    W A Mihatsch
    Department of Pediatrics, University of Ulm, Germany
    Acta Paediatr 90:196-8. 2001
    ..The present trial investigated whether a protein hydrolysate formula reduces the gastrointestinal transit time in preterm infants...
  14. pmc Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
    Purna C Kashyap
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 974305, USA
    Gastroenterology 144:967-77. 2013
    ..In addition to the direct influence that diet exerts on microbes, changes in microbiota composition and function can alter host functions such as gastrointestinal (GI) transit time, which in turn can further affect the microbiota...
  15. pmc Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system
    Jonas Worsøe
    Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark
    BMC Gastroenterol 11:145. 2011
    ..Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal transit. The aim was to test the validity of MTS-1 for assessment of gastric transit time and small intestinal ..
  16. ncbi The effect of different dosages of guar gum on gastric emptying and small intestinal transit of a consumed semisolid meal
    M A van Nieuwenhoven
    Department of Gastroenterology, Maastricht University, The Netherlands
    J Am Coll Nutr 20:87-91. 2001
    There is no consensus about the effect of guar gum supplementation on gastrointestinal transit. It has been suggested that guar gum slows gastric emptying and intestinal transit, thus inducing an increased feeling of satiety.
  17. ncbi Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    World J Gastroenterol 11:4865-8. 2005
    ..To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy...
  18. ncbi Gastrointestinal transit in patients with systemic sclerosis
    Lotte Fynne
    Department of Hepatology and Gastroenterology V, Neurogastroenterology Unit, Aarhus University Hospital, Denmark
    Scand J Gastroenterol 46:1187-93. 2011
    ..Gastrointestinal symptoms of SSc, including abdominal pain, bloating and discomfort, are common but diffuse and their pathophysiology remains obscure...
  19. ncbi Faster recovery of gastrointestinal transit after laparoscopy and fast-track care in patients undergoing colonic surgery
    Sjoerd H W van Bree
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 141:872-880.e1-4. 2011
    ..However, objective measures supporting faster GI recovery are lacking. Therefore, GI transit was measured following open and laparoscopic colorectal surgery with or without fast-track care...
  20. ncbi Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies
    S S C Rao
    Division of Gastroenterology Hepatology, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1009, USA
    Neurogastroenterol Motil 23:8-23. 2011
    ..Assessment of regional and/or whole gut transit times can provide direct measurements and diagnostic information to explain the cause of symptoms, and plan therapy...
  21. ncbi In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of Bifidobacterium
    L Masco
    Laboratory of Microbiology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Dairy Sci 90:3572-8. 2007
    ..potential of 24 probiotic product isolates and 42 human reference strains of Bifidobacterium to survive gastrointestinal transit under in vitro conditions...
  22. ncbi Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy
    Ankur Gupta
    Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Hepatol 53:849-55. 2010
    ..This cross-sectional study was carried out to elucidate the role of bacterial overgrowth of the small intestine and delayed intestinal transit among patients with MHE...
  23. ncbi [Colonic transit time in patient with liver cirrhosis]
    Young Hoon Kim
    Department of Internal Medicine, Hanyang University College of Medicine, San 17, Haengdang dong, Seongdong Gu, Seoul 133 792, Korea
    Korean J Gastroenterol 42:394-9. 2003
    ..Thus, the authors investigated the differences of colonic transit time between cirrhotic patients and normal controls with attention to factors that affect this change...
  24. ncbi Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit
    Anurag Agrawal
    Neurogastroenterology Unit, Gastrointestinal Sciences, School of Translational Medicine, University of Manchester, Manchester, UK
    Am J Gastroenterol 104:1998-2004. 2009
    ..Because constipation is often associated with delayed gastrointestinal transit, this study aimed at establishing whether patients with delayed transit show more distension and bloating ..
  25. ncbi Gastrointestinal transit and mucoadhesion of colloidal suspensions of Lycopersicon esculentum L. and Lotus tetragonolobus lectin-PLA microsphere conjugates in rats
    M J Montisci
    Laboratoire de Pharmacotechnie et Biopharmacie, UMR 8612, , , , France
    Pharm Res 18:829-37. 2001
    ..These results could be attributed both to unfavorable physicochemical characteristics of the conjugates and to premature adsorption of soluble mucin glycoproteins, preventing any further specific adhesion...
  26. ncbi The pharmacological effects of Daikenchuto, a traditional herbal medicine, on delayed gastrointestinal transit in rat postoperative ileus
    Yohei Tokita
    Central Research Laboratory, Tsumura and Co, Ibaraki, Japan
    J Pharmacol Sci 104:303-10. 2007
    ..POI was induced by laparotomy with manipulation of the gastrointestine under anesthesia, and gastrointestinal transit was calculated by migration of Evans blue. Daikenchuto (270 - 2,700 mg/kg, p.o...
  27. pmc Prognosis of constipation: clinical factors and colonic transit time
    F de Lorijn
    Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Centre, Amsterdam, Netherlands
    Arch Dis Child 89:723-7. 2004
    ..Measurement of colonic transit time (CTT) is sometimes used in the evaluation of patients with chronic constipation...
  28. ncbi Gastrointestinal transit, post-prandial lipaemia and satiety following 3 days high-fat diet in men
    M E Clegg
    Faculty of Education and Health Sciences, University of Limerick, Castletroy, Limerick, Ireland, UK
    Eur J Clin Nutr 65:240-6. 2011
    ..To date, no studies have shown any alteration in GE following shorter HF diets. The aim of this study was to assess if an HF, high-energy diet of 3 days can adapt gastrointestinal (GI) transit, blood lipids and satiety...
  29. ncbi Normal gastrointestinal transit after colonic resection using epidural analgesia, enforced oral nutrition and laxative
    L Basse
    Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark
    Br J Surg 88:1498-500. 2001
    ..The aim of this study was to assess the transit rate of the entire gastrointestinal tract after colonic resection with multimodal rehabilitation...
  30. ncbi Ileal brake: neuropeptidergic control of intestinal transit
    Gregg W Van Citters
    Division of Gastroinestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Curr Gastroenterol Rep 8:367-73. 2006
    ..Fat is the most potent trigger of these transit control mechanisms. The integrated circuitry of gut peptides and neurons involved in transit control in response to nutrients is described in this review...
  31. ncbi Effect of mosapride on gastrointestinal transit time and diagnostic yield of capsule endoscopy
    Wei Wei
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Gastroenterol Hepatol 22:1605-8. 2007
    ..The aim of this study was to determine the effect of oral mosapride on gastrointestinal transit time and the diagnostic yield of CE.
  32. ncbi Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB(1) receptors
    Marco Landi
    Research Center Sanofi Midy, Sanofi Synthelabo, SPA, Via G B Piranesi 38, 20137 Milan, Italy
    Eur J Pharmacol 450:77-83. 2002
    We studied the delay in gastric emptying and gastrointestinal transit induced by the cannabinoid receptor agonists (+)-WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)..
  33. pmc Impact of luxS and suppressor mutations on the gastrointestinal transit of Lactobacillus rhamnosus GG
    Sarah Lebeer
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, 3001 Leuven, Belgium
    Appl Environ Microbiol 74:4711-8. 2008
    It is generally believed that probiotic bacteria need to survive gastrointestinal transit to exert a health-promoting effect...
  34. ncbi Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models
    Ryosuke Kojima
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
    Pharmacology 84:227-33. 2009
    ..These results indicate that clonidine- and loperamide-induced delays in colonic transit are models of atonic and spastic constipation, respectively, and that mustard oil may be effective on both types of constipation...
  35. ncbi The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats
    Hiroyuki Fukuda
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Surg Res 131:290-5. 2006
    ..Dai-Kenchu-to (DKT), an herbal medicine, has been used for treating adhesive bowel obstruction in Japan. We studied whether DKT improves delayed GI transit after the operation, with or without morphine administration in rats...
  36. pmc Effects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation
    M L Manini
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 22:42-9, e7-8. 2010
    ..We assessed effects of Velusetrag on gastrointestinal transit and compared its pharmacokinetics in healthy volunteers (HV) and chronic constipation (CC) patients...
  37. ncbi The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndrome
    Riadh Sadik
    Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg 41345, Sweden
    Eur J Gastroenterol Hepatol 22:102-8. 2010
    ..The aim of this prospective study was to characterize the relationships between symptoms in IBS, GI transit, as a measure of GI motility, and BMI...
  38. pmc Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance
    J McCarthy
    Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland
    Gut 52:975-80. 2003
    ..Prophylactic efficacy against colitis following lactobacillus consumption in interleukin 10 (IL-10) knockout (KO) mice has been reported. Whether this applies equally to other probiotic strains is unknown, and the mechanism is unclear...
  39. ncbi Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice
    Christian Dursteler
    Department of Anaesthesiology, Hospital Universitario del Mar, Universidad Autonoma de Barcelona, Paseo Marítimo 25, 08003 Barcelona, Spain
    Eur J Pain 10:629-38. 2006
    ..Clinical studies suggest that tramadol-induced analgesia is partially antagonized by ondansetron...
  40. ncbi Gastrointestinal transit times in mice and humans measured with 27Al and 19F nuclear magnetic resonance
    Roman Schwarz
    Department of Biophysics, Biocenter, University of Basel, Switzerland
    Magn Reson Med 48:255-61. 2002
    ..For stomach emptying in mice the exponential decay constant was 74 min, whereas the half-time of the linear gastric emptying in humans was 30 min...
  41. ncbi Capsule endoscopy: improving transit time and image view
    Zvi Fireman
    Department of Gastroenterology, Hillel Yaffe, Hadera, Israel
    World J Gastroenterol 11:5863-6. 2005
    ..To evaluate the effect of various methods of small bowel preparation on the transit time and the quality of visualization of the entire small bowel mucosa...
  42. ncbi Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health
    April B M Grudell
    Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1114-9. 2008
    ..Our aim was to explore the effects of a beta(3)-AR agonist, solabegron, on gastrointestinal transit, safety, bowel function, plasma somatostatin, and solabegron pharmacokinetics (PK) following single and ..
  43. pmc Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation
    M Brunner
    Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, Austria
    Br J Clin Pharmacol 61:31-8. 2006
    The aims of the study were to: (1) evaluate the gastrointestinal transit, release and absorption of budesonide from tablets with a new multimatrix formulation (MMX) designed to release the drug throughout the whole colon, and (2) assess ..
  44. ncbi The effect of mosapride citrate on proximal and distal colonic motor function in the guinea-pig in vitro
    H S Kim
    Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Neurogastroenterol Motil 20:169-76. 2008
    ..The different distribution of neuronal and muscular 5-HT(4) receptors may support these findings. Therefore, mosapride may be a useful alternative to tegaserod and cisapride for constipation...
  45. ncbi Radiographic assessment of gastric emptying and gastrointestinal transit time in hybrid tilapia (Oreochromis niloticus x O. mossambicus)
    Hock Gan Heng
    Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Vet Radiol Ultrasound 48:132-4. 2007
    Hybrid tilapias (Oreochromis niloticus x O. mossambicus) were studied to determine gastric emptying and gastrointestinal transit time. The fish were divided into two groups. All fish were fasted for 12 h...
  46. ncbi The use of a wireless motility device (SmartPill®) for the measurement of gastrointestinal transit time after a dietary fibre intervention
    Derek Timm
    Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St Paul, MN 55108, USA
    Br J Nutr 105:1337-42. 2011
    Historically, measurement of gastrointestinal transit time has required collection and X-raying of faecal samples for up to 7 d after swallowing radio-opaque markers; a tedious, labour-intensive technique for both subjects and ..
  47. ncbi Acupuncture accelerates delayed gastrointestinal transit after abdominal surgery in conscious rats
    Jose L Balestrini
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Scand J Gastroenterol 40:734-5. 2005
  48. ncbi Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part 1: oral solutions
    Kirstin Thelen
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, 60438 Frankfurt am Main, Germany
    J Pharm Sci 100:5324-45. 2011
    ..The detailed model for GI transit and absorption presented in this study can help to understand the complex processes of oral absorption better and will be useful during the drug development process...
  49. ncbi Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part II: extension to describe performance of solid dosage forms
    Kirstin Thelen
    Johann Wolfgang Goethe University, Institute of Pharmaceutical Technology, 60438 Frankfurt am Main, Germany
    J Pharm Sci 101:1267-80. 2012
    ..It facilitates a comparative analysis of the parameters contributing to oral drug absorption and is thus a powerful tool for formulation design...
  50. ncbi Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima Aoba ku, Sendai 981 8558, Japan
    Eur J Pharm Sci 20:357-63. 2003
    ..loperamide, a peripheral mu-opioid receptor agonist and well-recognized antidiarrheal agent, on mouse gastrointestinal transit was compared with that of morphine in order to examine the development of tolerance to mu-opioid receptor ..
  51. ncbi Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit
    Pu Feng
    Department of Microbiology and Immunology, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 534:250-7. 2006
    ..DPDPE, delta1 agonist), administered via Alzet minipumps, on oral Salmonella infection and on gastrointestinal transit. The results show that all morphine-pelleted mice (26/26) had a marked increase in Salmonella burden in ..
  52. ncbi Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats
    F Calcina
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, Building 115, Room 224, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 134:39-49. 2005
    ..The aims of this study were to investigate the effect of intestinal ischemia on gastrointestinal transit and on the expression of enteric transmitters in the rat, and whether the glutamate N-methyl-d-aspartate ..
  53. ncbi Gastrointestinal transit of dosage forms in the pig
    S S Davis
    Institute of Pharmaceutical Sciences, University of Nottingham, UK
    J Pharm Pharmacol 53:33-9. 2001
    The gastrointestinal transit of liquid, pellet and tablet formulations was measured under fasted conditions in the domestic pig (n = 4) using the technique of gamma scintigraphy...
  54. ncbi Chronic idiopathic constipation: more than a simple colonic transit disorder
    Shabana Shahid
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Clin Gastroenterol 46:150-4. 2012
    ..The purposes of this study were to determine the percentage of constipated patients with the different pathophysiologic subtypes and and to evaluate what percentage of constipated patients has a diffuse GI tract transit disorder...
  55. ncbi Vincristine delays gastric emptying and gastrointestinal transit of liquid in awake rats
    A A Peixoto Júnior
    Departamento de Fisiologia e Farmacologia, Hospital Universitario Walter Cantidio, Universidade Federal do Ceara, Fortaleza, CE, Brasil
    Braz J Med Biol Res 42:567-73. 2009
    ..Chronic intravenous vincristine treatment delayed GE and GI transit of liquid. This effect correlated with the peak increase in colon weight but not with the pain threshold changes...
  56. ncbi Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects
    L Degen
    Division of Gastroenterology, University Hospital, Basel, Switzerland
    Aliment Pharmacol Ther 15:1745-51. 2001
    ..Tegaserod can act as a promotile agent throughout the gastrointestinal tract...
  57. pmc Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: roles of nitric oxide and prostaglandin E2
    Yu Chih Liang
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan, China
    World J Gastroenterol 11:357-61. 2005
    To investigate the effect of lipopolysaccharide (LPS) on the diarrheogenic activity, gastrointestinal transit (GIT), and intestinal fluid content and the possible role of nitric oxide (NO) and prostaglandin E2 (PGE2) in gastrointestinal ..
  58. ncbi Gastrointestinal transit in nonobese diabetic mouse: an animal model of human diabetes type 1
    M el-Salhy
    Department of Medicine, Institution of Public Health and Clinical Medicine, University Hospital, Umea, Sweden
    J Diabetes Complications 15:277-84. 2001
    b>Gastrointestinal transit (GI) in the nonobese diabetic (NOD) mouse, an animal model of human diabetes type 1, was examined in animals with short- (duration 1-5 days) and long-term (duration 28-35 days) diabetes...
  59. ncbi Intestinal inflammation and morphine tolerance alter the interaction between morphine and clonidine on gastrointestinal transit in mice
    M M Puig
    Anesthesiology Research Unit, Institut Municipal Investigacions Mediques IMIM, Department of Anesthesiology, Hospital Universitario del Mar, Barcelona, Spain
    Anesthesiology 93:219-30. 2000
    Morphine and clonidine show synergy or antagonism inhibiting gastrointestinal transit depending on their proportion and level of effect. Their interaction during morphine tolerance and intestinal inflammation were assessed.
  60. ncbi Relationship between lactose digestion, gastrointestinal transit time and symptoms in lactose malabsorbers after dairy consumption
    I Labayen
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Aliment Pharmacol Ther 15:543-9. 2001
    ..05). CONCLUSIONS: Delayed orocoecal transit time was associated with fewer gastrointestinal symptoms. The improved lactose digestion and tolerance of fresh yoghurt should be mainly attributed to the presence of living bacteria...
  61. ncbi Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats
    W A Mihatsch
    Department of Pediatrics, Ulm University, Ulm, Germany
    Biol Neonate 87:160-3. 2005
    Protein hydrolysate accelerates gastrointestinal transit (GIT) and feeding advancement in preterm infants compared to native protein...
  62. ncbi Complete small-bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramide
    Warwick Selby
    AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia
    Gastrointest Endosc 61:80-5. 2005
    ..Passage of the capsule endoscope to the colon occurs in only approximately three quarters of patients. This study assessed factors that might influence the completeness of small-bowel transit, including orally administered metoclopramide...
  63. ncbi Effects of intravenous fructose on gastric emptying and antropyloroduodenal motility in healthy subjects
    Julie E Stevens
    University of Adelaide, Royal Adelaide Hospital, SA, Australia
    Am J Physiol Gastrointest Liver Physiol 297:G1274-80. 2009
    ..003) compared with fructose and saline (P = NS for both) infusions. In conclusion, iv fructose slows GE and modulates gastric motility in healthy subjects, and the magnitude of slowing of GE is comparable to that induced by iv glucose...
  64. ncbi Gut transit is associated with gastrointestinal symptoms and gut hormone profile in patients with cirrhosis
    Evangelos Kalaitzakis
    Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Clin Gastroenterol Hepatol 7:346-52. 2009
    ....
  65. ncbi Endothelin ETA receptor blockade potentiates morphine analgesia but does not affect gastrointestinal transit in mice
    George A Matwyshyn
    Department of Biopharmaceutical Sciences M C 865, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    Eur J Pharmacol 543:48-53. 2006
    ..BMS182874, and endothelin ET(B) receptor agonist, IRL1620, on morphine analgesia and changes in gastrointestinal transit in male Swiss Webster mice. Results indicate that morphine (6 mg/kg, s.c...
  66. ncbi Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine
    Tomonori Nakamura
    Laboratory of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Jpn J Pharmacol 88:217-21. 2002
    ..relieve pain, effects of Dai-kenchu-to (DKT), a traditional Japanese herbal medicine (Kampo medicine), on gastrointestinal transit in mice or on the isolated guinea pig ileum were studied in special reference to morphine...
  67. ncbi Gastrointestinal transit of solid radiopaque markers in large and giant breed growing dogs
    M Weber
    Laboratory of Nutrition and Endocrinology, National Veterinary School of Nantes, BP 40706, 44307 Nantes Cedex 3, France
    J Anim Physiol Anim Nutr (Berl) 85:242-50. 2001
    ..These could explained why digestive function and sensitivity could be different in dogs from different sizes and breeds...
  68. pmc Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation
    A V Emmanuel
    St Mark's Hospital, Northwick Park, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gut 49:214-9. 2001
    ..Successful outcome after biofeedback treatment is associated with improved activity of the direct cerebral innervation to the gut and improved gut transit. This effect is gut specific; cardiovascular autonomic reflexes were not altered...
  69. ncbi Measurement of gastrointestinal transit
    Henry C Lin
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Dig Dis Sci 50:989-1004. 2005
    ..As we make progress in our understanding of the pathophysiology of transit disorders, the clinical usefulness of these diagnostic tests will be further enhanced...
  70. ncbi Gastro intestinal tracking and gastric emptying of solid dosage forms in rats using X-ray imaging
    Sigal Saphier
    The Department of Organic Chemistry, Israel Institute for Biological Research, Ness Ziona, Israel
    Int J Pharm 388:190-5. 2010
    The aim of this research was to study the gastrointestinal transit and gastric emptying of non-disintegrating solid dosage forms in rats using X-ray imaging...
  71. ncbi Evaluation of absorption kinetics of orally administered theophylline in rats based on gastrointestinal transit monitoring by gamma scintigraphy
    S Haruta
    Department of Hospital Pharmacy, Central Research Laboratories, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan
    J Pharm Sci 90:464-73. 2001
    ..Analysis using GI transit-absorption model and gamma scintigraphic technique made it possible to estimate the variable absorption kinetics regulated by GI transit with huge variability...
  72. ncbi Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice
    A D Suchitra
    Department of Pharmacology, JIPMER, Pondicherry 605006, India
    World J Gastroenterol 9:779-83. 2003
    ..To study the relative efficacy of cisapride, metoclopramide, domperidone, erythromycin and mosapride on gastric emptying (GE) and small intestinal transit (SIT) in morphine treated mice...
  73. ncbi Gastrointestinal transit time of nondisintegrating radio-opaque pellets in suckling and recently weaned piglets
    V Snoeck
    Laboratory of Veterinary Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Control Release 94:143-53. 2004
    ..These data are of crucial importance in the design of enteric-coated formulations for oral administration of vaccines and therapeutics to young piglets and for human research using the pig model...
  74. ncbi Characterizing gastrointestinal transit time in four lemur species using barium-impregnated polyethylene spheres (BIPS)
    J L Campbell
    Interdepartmental Nutrition Program, Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA
    Am J Primatol 64:309-21. 2004
    ..The flow of BIPS did not differ for VV and EF. These data reveal new information in addition to the total tract transit time, and complement existing knowledge regarding anatomy and diet...
  75. ncbi Effects of fasting on evaluation of gastrointestinal transit with charcoal meal
    S W Mittelstadt
    Drug Safety Assessment, Procter and Gamble Pharmaceuticals, Miami Valley Innovation Center, Cincinnati, OH 45252, USA
    J Pharmacol Toxicol Methods 52:154-8. 2005
    At the present time, most studies investigating gastrointestinal transit time with charcoal are conducted in fasted rats...
  76. ncbi Assessment of the relationship between body weight and gastrointestinal transit times measured by use of a wireless motility capsule system in dogs
    Carol S Boillat
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Am J Vet Res 71:898-902. 2010
    To assess the relationship between body weight and gastrointestinal transit times measured by use of a wireless motility capsule (WMC) system in healthy dogs.
  77. ncbi Model of rapid gastrointestinal transit in dogs: effects of muscarinic antagonists and a nitric oxide synthase inhibitor
    T Chiba
    Division of Gastroenterology, Mayo Clinic and Mayo Foundation, Rochester, MA 55905, USA
    Neurogastroenterol Motil 14:535-41. 2002
    Our aims were to establish a canine model of rapid gastrointestinal transit, and to test the effects of muscarinic receptor antagonists (atropine, pirenzepine, AF-DX116, and darifenacin), and an NOS inhibitor, L-nitro-N-arginine (L-NNA) ..
  78. ncbi Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption
    Felipe J O Varum
    The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Int J Pharm 395:26-36. 2010
    ..This is an oversimplification and in this review we discuss the effect of the highly variable gastrointestinal transit on the bioperformance of multiple-unit dosage forms, relative to their single-unit counterparts...
  79. ncbi Effect of bowel cleansing on colonic transit in constipation due to slow transit or evacuation disorder
    C E J Sloots
    Department of Gastroenterology of the Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Neurogastroenterol Motil 14:55-61. 2002
    ..However, because in an infrequent defecation pattern, the influence of faecal impaction is considerable, CTT should be applied with care for critical clinical decisions in the treatment of constipation...
  80. ncbi Effect of centrally administered apelin-13 on gastric emptying and gastrointestinal transit in mice
    Shuang Yu Lv
    Institute of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, PR China
    Peptides 32:978-82. 2011
    ..The present study was designed to investigate the effect of central apelin-13 on gastric emptying and gastrointestinal transit in mice. Intracerebroventricular (i.c.v...
  81. ncbi The effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formulation of poorly-water soluble drugs
    A W Basit
    Department of Pharmaceutics, The School of Pharmacy, University of London, UK
    Pharm Res 18:1146-50. 2001
    ..a pharmaceutical excipient frequently employed to enhance the solubility and bioavailability of poorly water-soluble drugs, on the gastrointestinal transit of liquid and pellet preparations in human subjects using gamma scintigraphy.
  82. ncbi Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa
    Kenjiro Matsumoto
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Eur J Pharmacol 549:63-70. 2006
    ..In the present study, we investigated the mechanism of antinociception and the inhibitory effect on gastrointestinal transit of 7-hydroxymitragynine, and compared its effects with those of morphine...
  83. ncbi Omeprazole-induced slowing of gastrointestinal transit in mice can be countered with tegaserod
    Alan Cowan
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 517:127-31. 2005
    ..These results show that omeprazole reduces aboral transit of luminal contents through the stomach and small bowel of mice and that this delay is reversed by tegaserod...
  84. ncbi Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans
    M Camilleri
    Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:30-8. 2007
    ..056) with the 10 and 20 mg t.i.d. doses. No safety issues were identified. ATI-7505 accelerates overall colonic transit and tends to accelerate GE and AC emptying and loosen stool consistency...
  85. ncbi Slow transit constipation: a disorder of pelvic autonomic nerves?
    C H Knowles
    Academic Department of Surgery, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, UK
    Dig Dis Sci 46:389-401. 2001
    ..We further present evidence for possible pathogenetic mechanisms underlying pelvic autonomic neuropathy in chronic idiopathic STC...
  86. ncbi Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice
    Mamoru Kakino
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Biosci Biotechnol Biochem 74:1550-5. 2010
    ..These findings indicate that EEAs exerted a laxative effect via acetylcholine receptors in the mouse constipation model...
  87. pmc Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Br J Pharmacol 129:1627-32. 2000
    ..p.) or intracerebroventricularly (i.c.v.) on upper gastrointestinal transit in control and in croton oil-treated mice...
  88. ncbi Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 18:540-7. 2003
    ..In tropical sprue (TS), response to antibiotics may suggest a role for bacterial contamination of the small bowel, which is known in diseases with prolonged orocecal transit time (OCTT)...
  89. ncbi Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls
    Richard J Saad
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Gastroenterol 105:403-11. 2010
    ..The aim of this study was to assess the correlation between stool characteristics (form and frequency) and gut transit in constipated and healthy adults...
  90. ncbi A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit
    Weidong Xie
    Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Eur J Pharmacol 510:113-20. 2005
    Improvement of gastrointestinal transit was thought to be a new tactic to treat postprandial hypertriglyceridemia in diabetic individuals with gastroparesis...
  91. ncbi Functional defecation disorder as a clinical subgroup of chronic constipation: analysis of symptoms and physiological parameters
    Mark T Eltringham
    Wansbeck General Hospital, Ashington, Northumberland, UK
    Scand J Gastroenterol 43:262-9. 2008
    ..The aim of this study was to use cluster analysis and factor analysis of defecatory symptoms and physiological parameters to look for evidence of subgroups in patients with functional constipation...
  92. ncbi Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor
    Patricia L Brubaker
    Departments of Physiology, University of Toronto, Room 3366 Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Clin Endocrinol Metab 87:3078-83. 2002
    ..two of the intestinal proglucagon-derived peptides, glucagon-like peptide (GLP)-1 and -2, and delayed gastrointestinal transit, was characterized in a patient with a neuroendocrine proglucagon-derived peptide tumor...
  93. ncbi Error analysis of classic colonic transit time estimates
    M Bouchoucha
    Hopital Laennec, Laboratory of Digestive Physiology, 75007 Paris, France
    Am J Physiol Gastrointest Liver Physiol 279:G520-7. 2000
    ..The relative error could easily reach 100% independent of the site of colonic transit delay. The normal values of total CTT are then 44.3+/-29.3 instead of 30.1+/-23.6 h for males and 68.2+/-54.4 instead of 47.1+/-28.2 h for females...
  94. pmc Factor analysis identifies subgroups of constipation
    Philip G Dinning
    Department of Gastroenterology, St George Hospital, University of New South Wales, Kogarah, NSW 2217, Australia
    World J Gastroenterol 17:1468-74. 2011
    ..To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction...
  95. ncbi Summary of probiotic activities of Bifidobacterium lactis HN019
    Mary Ellen Sanders
    Dairy and Food Culture Technologies, 7119 S Glencoe Ct, Centennial, CO 80122, USA
    J Clin Gastroenterol 40:776-83. 2006
    ..HN019 is a well-characterized probiotic strain with documented probiotic effects of meaningful magnitude especially in the area of immune system modulation...
  96. ncbi Capsule endoscopy for the evaluation of patients with chronic abdominal pain
    E Bardan
    Department of Gastroenterology, Chaim Sheba Medical Center and Tel Aviv University, Sackler School of Medicine, Israel
    Endoscopy 35:688-9. 2003
    ..The aim of our study was to determine the role of capsule endoscopy in the evaluation of patients with unexplained chronic abdominal pain...
  97. ncbi Influence of age and body size on gastrointestinal transit time of radiopaque markers in healthy dogs
    Mickaël P Weber
    Laboratory of Nutrition and Endocrinology, National Veterinary School of Nantes, France
    Am J Vet Res 63:677-82. 2002
    ....
  98. ncbi Role of progesterone signaling in the regulation of G-protein levels in female chronic constipation
    Zuo Liang Xiao
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Gastroenterology 128:667-75. 2005
    ..The cause and mechanisms responsible for this syndrome are unknown. Progesterone has been suggested as a possible contributing factor. Our aim was to investigate the site and mechanisms responsible for this colonic motility disorder...
  99. pmc Ghrelin improves delayed gastrointestinal transit in alloxan-induced diabetic mice
    Wen Cai Qiu
    Department of General Surgery, The Affiliated Sixth Hospital of Medical School, Shanghai Jiaotong University, Shanghai 200233, China
    World J Gastroenterol 14:2572-7. 2008
    To investigate the effects of ghrelin on delayed gastrointestinal transit in alloxan-induced diabetic mice.
  100. ncbi Clinical trial: effectiveness of chewing-gum in accelerating capsule endoscopy transit time--a prospective randomized, controlled pilot study
    P Apostolopoulos
    Department of Gastroenterology, NIMTS Hospital, Athens, Greece
    Aliment Pharmacol Ther 28:405-11. 2008
    ..Capsule endoscopy (CE) fails to reach the caecum in approximately 20% of patients. Data suggest that chewing-gum, simulating sham feeding, provokes the cephalic phase of gastrointestinal (GI) motor response and may increase GI motility...
  101. ncbi Acylated oleanane-type triterpene saponins with acceleration of gastrointestinal transit and inhibitory effect on pancreatic lipase from flower buds of chinese tea plant (Camellia sinensis)
    Masayuki Yoshikawa
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Chem Biodivers 6:903-15. 2009
    ..O. KUNTZE; Fujian Province) were found to exhibit accelerating effects on gastrointestinal transit in mice and inhibitory effects against pancreatic lipase...

Research Grants44

  1. Gastrointestinal Transit Measurement System
    DAVID KYNOR; Fiscal Year: 2006
    ..In many patients, measurement of gastrointestinal transit can provide important diagnostic information...
  2. Opioid tolerance and bowel dysfunction
    William L Dewey; Fiscal Year: 2013
    ..elucidate the mechanisms that lead to tolerance to many of the effects of opioids, including slowing of gastrointestinal transit but not constipation...
  3. Unique Opioid Analgesics With No Addiction Liability or Dysphoria
    John A Lawson; Fiscal Year: 2011
    ..PPL-101 elicits potent analgesia with minimal effects on gastrointestinal transit, respiration, physical dependence, and diuresis...
  4. Food Rheology and Exercise in Aging Humans
    WAYNE CAMPBELL; Fiscal Year: 2009
    ..e., glucose, insulin, leptin, neuropeptide Y, cholecystokinin and gastrointestinal transit time)...
  5. MOTILITY OF THE DIGESTIVE TRACT IN HEALTH AND DISEASE
    KEITH KELLY; Fiscal Year: 1993
    ..are: 1) To determine whether retrograde pacing of the duodenum transposed to the distal ileum would slow gastrointestinal transit and improve absorption in dogs with ileostomy...
  6. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..Human trials showed evidence of a prokinetic action on gastrointestinal transit. The general scientific aim of the proposed work is to understand how GDNF works in the "brain-in-the-gut"..
  7. Morphine Tolerance in Barrestin-2 KO Mice: Beyond Pain
    Laura Bohn; Fiscal Year: 2006
    ..questions: AIM I: To test whether morphine tolerance occurs in the suppression of respiration or gastrointestinal transit in mice that lack morphine antinociceptive tolerance...
  8. Gastrointestinal Transit Measurement System
    DAVID KYNOR; Fiscal Year: 2003
    ..In many patients, measurement of gastrointestinal transit can provide important diagnostic information...
  9. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  10. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  11. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..to determine whether CB receptor modulation influences the antral motor response to a standard meal and gastrointestinal transit and to evaluate the interaction of muscarinic cholinergic mechanisms with CB modulation;second, to ..
  12. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  13. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  14. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  15. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  16. Oleic Acid Effects on Transit and Absorption in SBS
    Charlene Compher; Fiscal Year: 2004
    ....
  17. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  18. SYNTHETIC SUBSTANCES CONTROLLING REPRODUCTION
    Jean Rivier; Fiscal Year: 2005
    ..Such molecules are not presently available to academic researchers. As in the past twenty years, collaborations with academic colleagues will be initiated, to maximize the impact of this research. ..
  19. Cancer Prevention Mastery-Model Internet Intervention
    Richard Winett; Fiscal Year: 2008
    ....
  20. CANCER PREVENTION PROGRAM IN RURAL CHURCHES
    Richard Winett; Fiscal Year: 2003
    ..Measures of SCT determinants will address the theoretical underpinnings of the intervention, and process measures will assess fidelity, dose, and contamination issues. ..
  21. RADIOLABLED PEPTIDES FOR IMAGING THROMBI AND EMBOLI
    LINDA KNIGHT; Fiscal Year: 2003
    ..abstract_text> ..
  22. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..receptors (NMDA-Rs) are likely to be involved in the [unreadable]OR-mediated impairment of gastrointestinal transit induced by prolonged [unreadable]OR activation...
  23. Effects of Short Chain Fatty Acids on Colonic Motility
    Toku Takahashi; Fiscal Year: 2009
    ..These results may provide a rational explanation as to how low concentrations of luminal SCFAs and stress contributes to the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS). ..
  24. NEUROENDOCRINE ALTERATIONS IN FIBROMYALGIA AND IBS
    Lin Chang; Fiscal Year: 2010
    ..abstract_text> ..
  25. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  26. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2010
    ....
  27. GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    Catia Sternini; Fiscal Year: 2002
    ..We also plan to characterize GRP receptor recycling and resensitization in cells that normally express GRP receptors: gastric G cells, Swiss 3T3 cells, and small cell lung carcinoma line NCI-H345 cells. ..
  28. Ethanol on Overnight Glucose Regulation in Diabetes
    Mark Burge; Fiscal Year: 2008
    ..These important studies will provide a scientific basis for the prevention of overnight hypoglycemia (and the attendant cost savings) by providing mechanistic insights into the causes of nocturnal hypoglycemia. [unreadable] [unreadable]..
  29. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITY
    Toku Takahashi; Fiscal Year: 2003
    ..This may have important clinical implications since OFQ or its analogues may be beneficial for the treatment of refractory constipation in humans. ..
  31. DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
    ALAN HOFMANN; Fiscal Year: 2005
    ..Results of this study should lead to clinical trials that test the efficacy of oral primary bile acids for constipation caused by defective bile acid biosynthesis. ..
  32. Radiolabeled Peptides for Imaging Tumor Angiogenesis
    LINDA KNIGHT; Fiscal Year: 2004
    ..A future benefit of this approach is the potential for targeted radiotherapy of tumors by labeling the same disintegrin with a therapeutic radionuclide. ..
  33. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  34. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  35. Somatostatin Receptor-Selective Agonists and Antagonists
    Jean Rivier; Fiscal Year: 2006
    ..abstract_text> ..
  36. Enteric Nervous System 2003
    Keith Sharkey; Fiscal Year: 2003
    ..From this picture there will be gaps - these are the challenges for the future. ..
  37. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
  38. Clinical and Translational Science Center at the University of New Mexico
    Mark Burge; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  39. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2006
    ..abstract_text> ..
  40. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  41. Food Rheology and Feeding in Lean and Obese Humans
    Richard Mattes; Fiscal Year: 2007
    ..abstract_text> ..
  42. HEDONICS AND DIETARY INTAKE OF FAT
    Richard Mattes; Fiscal Year: 2008
    ..This will be explored through stable isotope tracer studies for Aim 3. The proposed work will hold important public health, clinical, commercial and basic biological implications. [unreadable] [unreadable]..