magnetic resonance imaging

Summary

Summary: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Top Publications

  1. ncbi Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain
    N Tzourio-Mazoyer
    Groupe d Imagerie Neurofonctionnelle, UMR 6095 CNRS CEA, Universite de Caen, Université de Paris 5, France
    Neuroimage 15:273-89. 2002
  2. ncbi Advances in functional and structural MR image analysis and implementation as FSL
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Department of Clinical Neurology, John Radcliffe Hospital, Oxford University, Headington, Oxford OX3 9DU, UK
    Neuroimage 23:S208-19. 2004
  3. ncbi Unified segmentation
    John Ashburner
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 26:839-51. 2005
  4. ncbi A fast diffeomorphic image registration algorithm
    John Ashburner
    Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK
    Neuroimage 38:95-113. 2007
  5. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
  6. ncbi Complex brain networks: graph theoretical analysis of structural and functional systems
    Ed Bullmore
    University of Cambridge, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:186-98. 2009
  7. ncbi Fast robust automated brain extraction
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Hum Brain Mapp 17:143-55. 2002
  8. pmc The human brain is intrinsically organized into dynamic, anticorrelated functional networks
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:9673-8. 2005
  9. pmc Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
    Jonathan D Power
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 59:2142-54. 2012
  10. ncbi An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
    Joseph A Maldjian
    Department of Radiology, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Neuroimage 19:1233-9. 2003

Detail Information

Publications304 found, 100 shown here

  1. ncbi Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain
    N Tzourio-Mazoyer
    Groupe d Imagerie Neurofonctionnelle, UMR 6095 CNRS CEA, Universite de Caen, Université de Paris 5, France
    Neuroimage 15:273-89. 2002
    ..However, this tool does not alleviate the need for more sophisticated labeling strategies based on anatomical or cytoarchitectonic probabilistic maps...
  2. ncbi Advances in functional and structural MR image analysis and implementation as FSL
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Department of Clinical Neurology, John Radcliffe Hospital, Oxford University, Headington, Oxford OX3 9DU, UK
    Neuroimage 23:S208-19. 2004
    ..has focussed on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data...
  3. ncbi Unified segmentation
    John Ashburner
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 26:839-51. 2005
    ..A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function...
  4. ncbi A fast diffeomorphic image registration algorithm
    John Ashburner
    Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK
    Neuroimage 38:95-113. 2007
    ....
  5. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors...
  6. ncbi Complex brain networks: graph theoretical analysis of structural and functional systems
    Ed Bullmore
    University of Cambridge, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:186-98. 2009
    ..We also highlight some of the technical challenges and key questions to be addressed by future developments in this rapidly moving field...
  7. ncbi Fast robust automated brain extraction
    Stephen M Smith
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Hum Brain Mapp 17:143-55. 2002
    ..We describe the new method and give examples of results and the results of extensive quantitative testing against "gold-standard" hand segmentations, and two other popular automated methods...
  8. pmc The human brain is intrinsically organized into dynamic, anticorrelated functional networks
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:9673-8. 2005
    ..We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain...
  9. pmc Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
    Jonathan D Power
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 59:2142-54. 2012
    ..These results suggest the need for greater care in dealing with subject motion, and the need to critically revisit previous rs-fcMRI work that may not have adequately controlled for effects of transient subject movements...
  10. ncbi An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
    Joseph A Maldjian
    Department of Radiology, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Neuroimage 19:1233-9. 2003
    ..This tool represents a necessary evolution in fMRI data analysis for testing of more spatially complex hypotheses...
  11. pmc Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    Chris H Polman
    Department of Neurology, Free University, Amsterdam, The Netherlands
    Ann Neurol 69:292-302. 2011
    ..These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use...
  12. ncbi Nonparametric permutation tests for functional neuroimaging: a primer with examples
    Thomas E Nichols
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Hum Brain Mapp 15:1-25. 2002
    ..Practical considerations are given throughout, and relevant statistical concepts are expounded in appendices...
  13. ncbi Cortical surface-based analysis. I. Segmentation and surface reconstruction
    A M Dale
    Massachusetts General Hosp Harvard Medical School, Building 149, Charlestown, Massachusetts, 02129, USA
    Neuroimage 9:179-94. 1999
    ..Automated routines for unfolding and flattening the cortical surface are described in a companion paper. These procedures allow for the routine use of cortical surface-based analysis and visualization methods in functional brain imaging...
  14. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
    ..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...
  15. pmc Consistent resting-state networks across healthy subjects
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:13848-53. 2006
    ..These findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments...
  16. ncbi A global optimisation method for robust affine registration of brain images
    M Jenkinson
    University of Oxford, John Radcliffe Hospital, FMRIB Centre, Oxford OX3 9DU, UK
    Med Image Anal 5:143-56. 2001
    ....
  17. pmc The influence of head motion on intrinsic functional connectivity MRI
    Koene R A van Dijk
    Harvard University Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    Neuroimage 59:431-8. 2012
    ..These effects are important to consider when interpreting variation between groups and across individuals...
  18. ncbi Thresholding of statistical maps in functional neuroimaging using the false discovery rate
    Christopher R Genovese
    Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Neuroimage 15:870-8. 2002
    ..We demonstrate this approach using both simulations and functional magnetic resonance imaging data from two simple experiments.
  19. ncbi Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria"
    Chris H Polman
    VU Medical Center Amsterdam, Free University, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Neurol 58:840-6. 2005
    ..The 2005 Revisions to the McDonald Diagnostic Criteria for MS should simplify and speed diagnosis, whereas maintaining adequate sensitivity and specificity...
  20. ncbi Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain
    Bruce Fischl
    Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Rm 2328, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuron 33:341-55. 2002
    ..The technique is shown to be comparable in accuracy to manual labeling, and of sufficient sensitivity to robustly detect changes in the volume of noncortical structures that presage the onset of probable Alzheimer's disease...
  21. ncbi An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    Rahul S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
    Neuroimage 31:968-80. 2006
    ....
  22. ncbi Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
    W I McDonald
    Royal College of Physicians, London, United Kingdom
    Ann Neurol 50:121-7. 2001
    ..The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods...
  23. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  24. ncbi Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
    Michael D Fox
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 8:700-11. 2007
    ..examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity...
  25. ncbi A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
    Simon B Eickhoff
    Institut fur Medizin, Forschungszentrum Julich, Julich, Germany
    Neuroimage 25:1325-35. 2005
    ..This new toolbox provides an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space...
  26. ncbi Dynamic causal modelling
    K J Friston
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 19:1273-302. 2003
    ..psychophysiologic interactions). However, unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic...
  27. pmc Correspondence of the brain's functional architecture during activation and rest
    Stephen M Smith
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:13040-5. 2009
    ..Independently, we extract the major covarying networks in the resting brain, as imaged with functional magnetic resonance imaging in 36 subjects at rest...
  28. ncbi Automated Talairach atlas labels for functional brain mapping
    J L Lancaster
    Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284, USA
    Hum Brain Mapp 10:120-31. 2000
    ..Additional suggested applications of the TD system include interactive labeling, anatomical grouping of activation foci, lesion-deficit analysis, and neuroanatomy education...
  29. pmc REST: a toolkit for resting-state functional magnetic resonance imaging data processing
    Xiao Wei Song
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    PLoS ONE 6:e25031. 2011
    ..REST is an open-source package and is freely available at http://www.restfmri.net...
  30. pmc Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 101:4637-42. 2004
    ..Finally, a goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD...
  31. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
    ..There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans...
  32. pmc Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    Clifford R Jack
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA jack cliff
    Lancet Neurol 9:119-28. 2010
    ....
  33. pmc Toward discovery science of human brain function
    Bharat B Biswal
    Department of Radiology, New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:4734-9. 2010
    ..To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/...
  34. ncbi A nonparametric method for automatic correction of intensity nonuniformity in MRI data
    J G Sled
    McConnell Brain Imaging Centre, Montreal Neurological Institute and McGill University, Canada
    IEEE Trans Med Imaging 17:87-97. 1998
    ..The performance of this method is evaluated using both real and simulated MR data...
  35. ncbi Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm
    Y Zhang
    FMRIB Centre, John Radcliffe Hospital, University of Oxford, UK
    IEEE Trans Med Imaging 20:45-57. 2001
    ..As an example, we show how the bias field correction algorithm of Guillemaud and Brady (1997) can be incorporated into this framework to achieve a three-dimensional fully automated approach for brain MR image segmentation...
  36. ncbi A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs
    Sophie Achard
    Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 26:63-72. 2006
    ..Here, we applied the discrete wavelet transform to functional magnetic resonance imaging (fMRI) time series, acquired from healthy volunteers in the resting state, to estimate frequency-..
  37. pmc Prediction of individual brain maturity using fMRI
    Nico U F Dosenbach
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 329:1358-61. 2010
    Group functional connectivity magnetic resonance imaging (fcMRI) studies have documented reliable changes in human functional brain maturity over development...
  38. ncbi Nonrigid registration using free-form deformations: application to breast MR images
    D Rueckert
    Division of Radiological Sciences and Medical Engineering, Guy s, King s, and St Thomas School of Medicine, King s College London, Guy s Hospital, London, UK
    IEEE Trans Med Imaging 18:712-21. 1999
    ..The results clearly indicate that the nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms...
  39. ncbi Anterior cingulate conflict monitoring and adjustments in control
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Science 303:1023-6. 2004
    ....
  40. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
    Functional magnetic resonance imaging (fMRI) is widely used to study the operational organization of the human brain, but the exact relationship between the measured fMRI signal and the underlying neural activity is unclear...
  41. ncbi The cognitive control of emotion
    Kevin N Ochsner
    Department of Psychology, Columbia University, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Trends Cogn Sci 9:242-9. 2005
    ..Taken together, the results suggest a functional architecture for the cognitive control of emotion that dovetails with findings from other human and nonhuman research on emotion...
  42. pmc Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia
    Amit Etkin
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305, USA
    Am J Psychiatry 164:1476-88. 2007
    ..The authors also compared these deficits to the neural systems engaged during anticipatory anxiety in healthy subjects...
  43. ncbi Psychophysiological and modulatory interactions in neuroimaging
    K J Friston
    Wellcome Department of Cognitive Neurology, London, United Kingdom
    Neuroimage 6:218-29. 1997
    ..We illustrate these points using a functional magnetic resonance imaging study of attention to visual motion and a position emission tomography study of visual priming...
  44. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
    ....
  45. ncbi Neural systems supporting interoceptive awareness
    Hugo D Critchley
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, and Autonomic Unit, National Hospital for Neurology and Neurosurgery, University College London Hospitals, UK
    Nat Neurosci 7:189-95. 2004
    ..We measured regional brain activity by functional magnetic resonance imaging (fMRI) during an interoceptive task wherein subjects judged the timing of their own heartbeats...
  46. pmc Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function
    D A Gusnard
    Mallinckrodt Institute of Radiology and Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:4259-64. 2001
    ..In this functional magnetic resonance imaging (fMRI) study, subjects made two judgments, one self-referential, the other not, in response to ..
  47. ncbi User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability
    Paul A Yushkevich
    Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, PA 19104 6274, USA
    Neuroimage 31:1116-28. 2006
    ..Analogous results for lateral ventricle segmentation are provided...
  48. pmc Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration
    Arno Klein
    New York State Psychiatric Institute, Columbia University, NY, NY 10032, USA
    Neuroimage 46:786-802. 2009
    ..Updates will be published on the http://www.mindboggle.info/papers/ website...
  49. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
    ..We conclude that only that part of the pain network associated with its affective qualities, but not its sensory qualities, mediates empathy...
  50. pmc Efficiency and cost of economical brain functional networks
    Sophie Achard
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS Comput Biol 3:e17. 2007
    ..We investigated the efficiency and cost of human brain functional networks measured using functional magnetic resonance imaging (fMRI) in a factorial design: two groups of healthy old (N = 11; mean age = 66...
  51. ncbi Self-projection and the brain
    Randy L Buckner
    Department of Psychology and Center for Brain Science, Harvard University, William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Trends Cogn Sci 11:49-57. 2007
    ....
  52. pmc Electrophysiological signatures of resting state networks in the human brain
    D Mantini
    Institute of Advanced Biomedical Technologies and Department of Clinical Sciences and Bio imaging, G d Annunzio University Foundation, G D Annunzio University, Chieti 66013, Italy
    Proc Natl Acad Sci U S A 104:13170-5. 2007
    ..approach that combines information from simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI)...
  53. ncbi Revised diagnostic criteria for neuromyelitis optica
    D M Wingerchuk
    Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Neurology 66:1485-9. 2006
    ..A serum autoantibody marker, NMO-IgG, is highly specific for NMO. The authors propose revised NMO diagnostic criteria that incorporate NMO-IgG status...
  54. ncbi A method for making group inferences from functional MRI data using independent component analysis
    V D Calhoun
    Division of Psychiatric Neuro Imaging, Johns Hopkins University, Baltimore, Maryland, USA
    Hum Brain Mapp 14:140-51. 2001
    ....
  55. ncbi A default mode of brain function: a brief history of an evolving idea
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 37:1083-90; discussion 1097-9. 2007
    ..Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships...
  56. pmc Predicting human resting-state functional connectivity from structural connectivity
    C J Honey
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 106:2035-40. 2009
    ....
  57. pmc The organization of the human cerebral cortex estimated by intrinsic functional connectivity
    B T Thomas Yeo
    Harvard University, Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    J Neurophysiol 106:1125-65. 2011
    ..We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition...
  58. pmc Investigations into resting-state connectivity using independent component analysis
    Christian F Beckmann
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Philos Trans R Soc Lond B Biol Sci 360:1001-13. 2005
    Inferring resting-state connectivity patterns from functional magnetic resonance imaging (fMRI) data is a challenging task for any analytical technique...
  59. ncbi The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  60. ncbi Learning the value of information in an uncertain world
    Timothy E J Behrens
    FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 10:1214-21. 2007
    ..Furthermore, variations in this ACC signal across the population predict variations in subject learning rates. Our results provide a formal account of how we weigh our different experiences in guiding our future actions...
  61. ncbi How brains beware: neural mechanisms of emotional attention
    Patrik Vuilleumier
    Laboratory for Neurology and Imaging of Cognition, Department of Neurosciences and Clinic of Neurology, University Medical Center, Geneva, Switzerland
    Trends Cogn Sci 9:585-94. 2005
    ..This work should help to elucidate the neural processes and temporal dynamics governing the integration of cognitive and affective influences in attention and behaviour...
  62. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
    ..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
  63. pmc The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?
    Kevin Murphy
    Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD 20892 1148, USA
    Neuroimage 44:893-905. 2009
    ..These results call into question the interpretation of negatively correlated regions in the brain when using global signal regression as an initial processing step...
  64. ncbi Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI
    K Luan Phan
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Neuroimage 16:331-48. 2002
    Neuroimagingstudies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have begun to describe the functional neuroanatomy of emotion...
  65. ncbi Default-mode brain dysfunction in mental disorders: a systematic review
    Samantha J Broyd
    Institute for Disorders of Impulse and Attention, Developmental Brain Behaviour Laboratory, School of Psychology, University of Southampton, UK
    Neurosci Biobehav Rev 33:279-96. 2009
    ..Finally, we provide an integrative overview and highlight important challenges and tasks for future research...
  66. pmc Distinct brain networks for adaptive and stable task control in humans
    Nico U F Dosenbach
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:11073-8. 2007
    ..These two independent networks appear to operate on different time scales and affect downstream processing via dissociable mechanisms...
  67. pmc Functional network organization of the human brain
    Jonathan D Power
    Department of Neurology, Washington University in Saint Louis, St Louis, MO 63130, USA
    Neuron 72:665-78. 2011
    ..The modified voxelwise graph also reveals spatial motifs in the patterning of systems across the cortex...
  68. pmc A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
    Devarajan Sridharan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:12569-74. 2008
    ..Here, we use functional magnetic resonance imaging (fMRI) to investigate the mechanisms underlying switching of brain networks in three different ..
  69. ncbi Network modelling methods for FMRI
    Stephen M Smith
    FMRIB Oxford University Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neuroimage 54:875-91. 2011
    ....
  70. ncbi What we can do and what we cannot do with fMRI
    Nikos K Logothetis
    Max Planck Institute for Biological Cybernetics, 72076 Tuebingen, Germany, and Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PL, UK
    Nature 453:869-78. 2008
    Functional magnetic resonance imaging (fMRI) is currently the mainstay of neuroimaging in cognitive neuroscience...
  71. pmc The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods
    Clifford R Jack
    Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 27:685-91. 2008
    ..b>Magnetic resonance imaging (MRI), (18F)-fluorodeoxyglucose positron emission tomography (FDG PET), urine serum, and cerebrospinal ..
  72. ncbi Neurophysiological architecture of functional magnetic resonance images of human brain
    Raymond Salvador
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Cereb Cortex 15:1332-42. 2005
    We investigated large-scale systems organization of the whole human brain using functional magnetic resonance imaging (fMRI) data acquired from healthy volunteers in a no-task or 'resting' state...
  73. ncbi Cortical mechanisms of human imitation
    M Iacoboni
    Brain Mapping Center, Neuropsychiatric Institute, Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095 7085, USA
    Science 286:2526-8. 1999
    ..Brain activity was measured with functional magnetic resonance imaging. If the direct matching hypothesis is correct, there should be areas that become active during finger ..
  74. ncbi Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder
    Junran Zhang
    Huaxi Magnetic Resonance Research Center, Department of Radiology, Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China
    Biol Psychiatry 70:334-42. 2011
    ....
  75. ncbi Emerging concepts for the dynamical organization of resting-state activity in the brain
    Gustavo Deco
    Institucio Catalana de Recerca i Estudis Avancats, Universitat Pompeu Fabra, Computational Neuroscience, Plaça de la Mercè, 10 12, 08002 Barcelona, Spain
    Nat Rev Neurosci 12:43-56. 2011
    ..We propose that the formation and dissolution of resting-state patterns reflects the exploration of possible functional network configurations around a stable anatomical skeleton...
  76. pmc Resting-state functional connectivity reflects structural connectivity in the default mode network
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cereb Cortex 19:72-8. 2009
    Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications...
  77. pmc Exercise training increases size of hippocampus and improves memory
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 108:3017-22. 2011
    ..These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function...
  78. pmc Circular analysis in systems neuroscience: the dangers of double dipping
    Nikolaus Kriegeskorte
    Laboratory of Brain and Cognition, US National Institute of Mental Health, Bethesda, Maryland, USA
    Nat Neurosci 12:535-40. 2009
    ..Spurious effects can appear in the context of both univariate activation analysis and multivariate pattern-information analysis. We suggest a policy for avoiding circularity...
  79. pmc Neurodegenerative diseases target large-scale human brain networks
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:42-52. 2009
    ..Future studies may clarify how these complex systems are assembled during development and undermined by disease...
  80. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
    ..We scanned human participants with functional magnetic resonance imaging while they engaged in instrumental conditioning...
  81. ncbi The anatomy of language: a review of 100 fMRI studies published in 2009
    Cathy J Price
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Ann N Y Acad Sci 1191:62-88. 2010
    ..Anatomical and functional connectivity studies are now required to identify the processing pathways that integrate these areas to support language...
  82. pmc Cortical substrates for exploratory decisions in humans
    Nathaniel D Daw
    Gatsby Computational Neuroscience Unit, University College London UCL, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nature 441:876-9. 2006
    ..using this characterization to classify decisions as exploratory or exploitative, we employ functional magnetic resonance imaging to show that the frontopolar cortex and intraparietal sulcus are preferentially active during ..
  83. ncbi Small-world anatomical networks in the human brain revealed by cortical thickness from MRI
    Yong He
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
    Cereb Cortex 17:2407-19. 2007
    ..To our knowledge, this study provides the first report of small-world properties and degree distribution of anatomical networks in the human brain using cortical thickness measurements...
  84. ncbi Beyond mind-reading: multi-voxel pattern analysis of fMRI data
    Kenneth A Norman
    Department of Psychology, Princeton University, Green Hall, Washington Road, Princeton, NJ 08540, USA
    Trends Cogn Sci 10:424-30. 2006
    ..We review how researchers are using MVPA methods to characterize neural coding and information processing in domains ranging from visual perception to memory search...
  85. ncbi Anterior cingulate cortex, error detection, and the online monitoring of performance
    C S Carter
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Science 280:747-9. 1998
    ..In this study, event-related functional magnetic resonance imaging was used to examine ACC function...
  86. ncbi The architecture of cognitive control in the human prefrontal cortex
    Etienne Koechlin
    Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
    Science 302:1181-5. 2003
    ..The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications...
  87. ncbi The neural basis of economic decision-making in the Ultimatum Game
    Alan G Sanfey
    Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
    Science 300:1755-8. 2003
    ..We used functional magnetic resonance imaging of Ultimatum Game players to investigate neural substrates of cognitive and emotional processes involved ..
  88. ncbi Disrupted small-world networks in schizophrenia
    Yong Liu
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    Brain 131:945-61. 2008
    ..the topological properties of human brain functional networks derived from resting-state functional magnetic resonance imaging (fMRI)...
  89. ncbi Distributed and overlapping representations of faces and objects in ventral temporal cortex
    J V Haxby
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 293:2425-30. 2001
    ..architecture of the object vision pathway in the human brain was investigated using functional magnetic resonance imaging to measure patterns of response in ventral temporal cortex while subjects viewed faces, cats, five ..
  90. ncbi Small-world networks and functional connectivity in Alzheimer's disease
    C J Stam
    Department of Clinical Neurophysiology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Cereb Cortex 17:92-9. 2007
    ..Graph theoretical analysis may be a useful approach to study the complexity of patterns of interrelations between EEG channels...
  91. ncbi Repetition and the brain: neural models of stimulus-specific effects
    Kalanit Grill-Spector
    Department of Psychology, Stanford University, Stanford, CA 94305, USA
    Trends Cogn Sci 10:14-23. 2006
    ..We also discuss future directions for distinguishing between these models, which will be important for understanding the neural consequences of repetition and for interpreting repetition-related effects in neuroimaging data...
  92. pmc Wandering minds: the default network and stimulus-independent thought
    Malia F Mason
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
    Science 315:393-5. 2007
    ..In addition, individuals' reports of the tendency of their minds to wander were correlated with activity in this network...
  93. ncbi Hemispheric asymmetry reduction in older adults: the HAROLD model
    Roberto Cabeza
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Psychol Aging 17:85-100. 2002
    ..They may have a cognitive or neural origin, and they may reflect regional or network mechanisms. The HAROLD model is a cognitive neuroscience model that integrates ideas and findings from psychology and neuroscience of aging...
  94. ncbi Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring
    Stefan Debener
    Institute of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center, Hamburg University, D 20246 Hamburg, Germany
    J Neurosci 25:11730-7. 2005
    ..Here, we report a direct coupling between the event-related electroencephalogram (EEG), functional magnetic resonance imaging (fMRI), and behavioral measures of performance monitoring in humans...
  95. ncbi Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis
    Peter Fransson
    MR Research Center, Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska Institute Karolinska University Hospital, Stockholm, Sweden
    Hum Brain Mapp 26:15-29. 2005
    ..the perspective of the presence of low-frequency blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal changes (0.012-0.1 Hz) in the resting brain...
  96. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment...
  97. ncbi Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
    ..We quantified longitudinal magnetic resonance imaging (MRI) scans of 92 nondemented older adults (age 59-85 years at baseline) in the Baltimore Longitudinal ..
  98. pmc Top-down facilitation of visual recognition
    M Bar
    Martinos Center at Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:449-54. 2006
    ..The present study combined magnetoencephalography, which has superior temporal resolution, functional magnetic resonance imaging, and a behavioral task that yields successful recognition with stimulus repetitions...
  99. ncbi The processing of temporal pitch and melody information in auditory cortex
    Roy D Patterson
    Centre for the Neural Basis of Hearing, Physiology Department, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Neuron 36:767-76. 2002
    ..The results support the view that there is hierarchy of pitch processing in which the center of activity moves anterolaterally away from primary auditory cortex as the processing of melodic sounds proceeds...
  100. ncbi 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
    Lukas Pezawas
    Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive 4S235, Bethesda, Maryland 20892 1379, USA
    Nat Neurosci 8:828-34. 2005
    ....
  101. ncbi Generalized autocalibrating partially parallel acquisitions (GRAPPA)
    Mark A Griswold
    Julius Maximilians Universitat Wurzburg, Physikalisches Institut, Wurzburg, Germany
    Magn Reson Med 47:1202-10. 2002
    ..Finally, in vivo GRAPPA images are shown which demonstrate the utility of the technique...

Research Grants79

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..emotional and cognitive processing in youth with active IBD and depression using brain functional magnetic resonance imaging compared to youth with IBD and no depression, and normal controls;and 2) the efficacy of a combined CBT-..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Oral drug will be initiated within 12 hours and continued for 7 days. Magnetic resonance imaging (MRI) with tissue tagging and gadolinium perfusion will be performed at 2 days and 7 days after I/R ..
  3. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..b>Magnetic resonance imaging (MRI) to evaluate body fat mass/distribution, integrated positron-emission tomography and computed ..
  4. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..emission tomography (PET) scanning to evaluate insulin stimulated glucose uptake in the heart, and cine-magnetic resonance imaging to evaluate insulin sensitive cardiac diastolic relaxation...
  5. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Rejection will be assessed using florine-19 magnetic resonance imaging to measure in allografts localized inflammation, an early sign of rejection...
  6. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..2- FA positron emission tomography (PET) scanning session, (3) a structural magnetic resonance imaging scan within one week of the initial PET session, (4) ten weeks of standard treatment with a nicotine ..
  7. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..our objectives, we will use powerful tandem mass spectrometry, medicinal chemistry, high-resolution magnetic resonance imaging, and in vivo experimental models of stroke in rats and 12/15-lipoxygenase (LOX)-deficient mice...
  8. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..research study on affective disorders, (2) training in the design, execution, and analysis of functional magnetic resonance imaging (fMRI) experiments, and (3) development of methodological expertise in molecular genetics. Environment...
  9. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..Therefore, the objective of this study is to validate the potential of magnetic resonance imaging (MRI) and spectroscopy (MRS) to monitor disease progression and the response to therapeutic ..
  10. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..headaches and sudden infant death syndrome, and also to contribute to the signals observed in functional magnetic resonance imaging. My laboratory has developed several electrochemically based techniques for in vivo measurements of ..
  11. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..b>Magnetic resonance imaging (MRI) to evaluate body fat mass/distribution, integrated positron-emission tomography and computed ..
  12. A Rodent Model to Study Links Among Diet, Visceral Adipose and Cardiomyopathy
    MELINDA ANN FRYE; Fiscal Year: 2013
    ..b>Magnetic resonance imaging (MRI) will be used to quantitate visceral adipose mass, and diet- induced changes in the myocardial and ..
  13. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013
    ..The long-term goal of my research career is to use state-of-the-art, non-invasive brain imaging methods (magnetic resonance imaging and spectroscopy (MRI/MRS) and positron emission tomography (PET)) to assess brain metabolic, ..
  14. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..perfusion, ischemia, and microvascular integrity, in conjunction with blood oxygen level- dependent magnetic resonance imaging assessment of myocardial oxygenation in response to increased cardiac demand...
  15. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..will be employed, including peripheral quantitative computed tomography (pQCT), visual assessments of magnetic resonance imaging (MRI) data, MR relaxometry and magnetic resonance spectroscopy to measure bone mineral density and ..
  16. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..To do this, we aim to use functional magnetic resonance imaging (fMRI) and [11C]raclopride Positron Emission Tomography (PET) during a physiological challenge (monetary ..
  17. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..In this proposal, we would like to test and validate non invasive magnetic resonance imaging (MRI) methods based on advanced diffusion (intravoxel incoherent motion diffusion MRI: IVIM DW-MRI) and ..
  18. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..To investigate BEX- induced changes in mammary tumors. Magnetic Resonance Imaging (MRI) techniques will be employed in this study to closely monitor the starting time and accurately ..
  19. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..also assess NAA and glutamate using spectroscopy and hippocampal and amygdala volume using structural magnetic resonance imaging. We have assembled a research team with expertise in mood disorders, clinical trials, neuropsychology, ..
  20. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..Actual renal ischemia is measured in each kidney by estimating with magnetic resonance imaging (MRI), blood (capillary) oxygen (O2) levels of deoxyhemoglobin (BOLD technique)...
  21. Metabolic Dysfunction and Neuroprotection after Pediatric Head Injury
    Susanna Scafidi; Fiscal Year: 2013
    ..immunohistochemistry, enzyme activity measurements, ex vivo NMR spectroscopy, state of the art in vivo Magnetic resonance imaging (MRI) and Magnetic resonance spectroscopy (MRS) and other methods in collaboration with the mentors will ..
  22. Delivery issues in lung cancer CNS metastases
    Edward A Neuwelt; Fiscal Year: 2013
    ..We propose to evaluate the heterogeneity of brain tumor vasculature using new dynamic magnetic resonance imaging (MRI) techniques, and correlate changes in tumor blood volume and vascular permeability with drug ..
  23. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..A needle-guide robot that is uniquely capable of operating inside magnetic resonance imaging (MRI) scanners will be developed for prostate biopsy and tested for clinical feasibility...
  24. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..Completion of the proposal will include functional studies consisting magnetic resonance imaging, infarct size, left ventricular wall thickness, and leukocyte infiltration in rat model...
  25. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..nanodevice assembly and chemistry (Boyes), and in vivo optical, computed tomography, and magnetic resonance imaging (Serkova)...
  26. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..While magnetic resonance imaging (MRI) consistently shows a distinctive white matter disturbance in the corpus callosum, lesions commonly ..
  27. Neuroendocrine Contribution to Behavior &Cognition in the Female Lifespan
    C NEILL NEILL EPPERSON; Fiscal Year: 2013
    ..2007b;Amin et al., 2006b) led me to become increasingly interested in the utility of functional magnetic resonance imaging (fMRI)...
  28. PET TUMOR AND PROLIFERATION IMAGING VIA CATIONIC AMINO ACID TRANSPORT
    JONATHAN EDWARD MCCONATHY; Fiscal Year: 2013
    ..tumor models, kinetic analysis of PET tracers, and translational and clinical research using advanced magnetic resonance imaging (MRI) in conjunction with PET tracers...
  29. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..provided by applicant): The objective of this research proposal is to develop a series of steroid-based magnetic resonance imaging (MRI) contrast agents to facilitate molecular characterization of the status and function of steroid ..
  30. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..considerations, rheumatologic and orthopedic issues in diagnosis and treatment);2) advanced magnetic resonance imaging (MRI) techniques (MR physics, pulse sequence design, image processing), and 3) design of patient-..
  31. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..This study will use brain imaging technologies (positron emission tomography [PET] and functional magnetic resonance imaging [fMRI]) to measure specific components of serotonergic and dopaminergic neurocircuits and to investigate ..
  32. Immediate and Delayed Effects of Morphine on Brain Circuits: Animal and Human Cor
    Dusica Bajic; Fiscal Year: 2013
    ..Functional magnetic resonance imaging (fMRI) in both rats and children will allow a translational systems level investigation of prolonged ..
  33. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    RODICA BUSUI POP-BUSUI; Fiscal Year: 2013
    ..Recently, magnetic resonance imaging (MRI) myocardial tagging has been used to demonstrate increased LV torsion in T1DM patients, a measure ..
  34. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2012
    ..While magnetic resonance imaging (MRI) has become an important diagnostic tool providing noninvasive evidence of MS lesions, conventional ..
  35. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2012
    ..of hepatic iron concentration by the high-Tc susceptometer with (i) estimates derived from liver magnetic resonance imaging (MRI) relaxation rates (R2, R2*, signal intensity ratios), (ii) with determinations of serum ferritin, ..
  36. TARGETING FLIP FOR PROSTATE CANCER PREVENTION
    Addanki P Kumar; Fiscal Year: 2012
    ..Suppression of androgen independent tumors will be monitored by (i) sequential non-invasive magnetic resonance imaging (MRI) every two weeks;(ii) histological evaluation of the prostate at the termination of the experiment ..
  37. In vivo imaging of encapsulated stem cells in mouse models of tumor resection
    Khalid A Shah; Fiscal Year: 2013
    ..pharmacokinetics of therapeutic proteins and their efficacy by in vivo BLI, intravital microscopy (IVM), magnetic resonance imaging (MRI) and positron emission tomography (PET) and thus to fine tune the proposed approaches...
  38. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
    ..Elizabeth Barrett-Connor, and David Brenner, proposes to measure liver fat, quantitatively, by a novel magnetic resonance imaging (MRI) technique, in a large, previously well-characterized, existing, twin-pair cohort in humans: (..
  39. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..Hybrid PET - computed tomography (CT) or PET - magnetic resonance imaging (MRI) devices are now available that enable co-registration of the molecular PET image to the vascular ..
  40. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ..imaging probes that are capable of identifying and monitoring atherosclerotic plaque progression by magnetic resonance imaging (MRI)...
  41. Cerebrovascular Disease and its Consequences in the Strong Study Cohort
    Dedra S Buchwald; Fiscal Year: 2013
    ..b>Magnetic resonance imaging (MRI) has redefined CBVD in large cohort studies, such as the Cardiovascular Health Study (CHS) and ..
  42. CARDIA Echocardiography Reading Center
    Joao A C Lima; Fiscal Year: 2012
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  43. CARDIA ECHO RC
    Joao A C Lima; Fiscal Year: 2011
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  44. CARDIA
    Sharina D Person; Fiscal Year: 2010
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  45. CARDIA
    O Dale Williams; Fiscal Year: 2011
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  46. Coronary Artery Risk Development in Young Adults (CARDIA) Study - CC
    James Shikany; Fiscal Year: 2012
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  47. CARDIA ECHO RC CAN 9-8470189
    Joao Lima; Fiscal Year: 2009
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  48. CARDIA ECHO RC
    Joao Lima; Fiscal Year: 2010
    ..Additionally, the next examination will study the Brain Magnetic Resonance Imaging (MRI) in a subset of the participants...
  49. Volumetric Perfusion MRI of Liver Tumors to Detect Early Response to Chemotherapy
    Scott B Reeder; Fiscal Year: 2010
    ..that measure early response to anti-angiogenic chemotherapeutic agents in liver tumors, using new magnetic resonance imaging (MRI) methods that measure blood flow to tumors (perfusion)...
  50. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..for use in optical imaging (OI) experiments, or capable of altering water relaxation rates, for use in magnetic resonance imaging (MRI) studies. Fluorescent reporters include xanthenone and single-walled carbon nanotube derivatives...
  51. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..b>Magnetic resonance imaging (MRI) studies reveal one out of three patients may suffer a new brain lesion following cardiac ..
  52. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..b>Magnetic resonance imaging (MRI) studies reveal one out of three patients may suffer a new brain lesion following cardiac ..
  53. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Studies using the magnetic resonance imaging (MRI) technique termed diffusion tensor imaging (DTI) have found that fractional anisotropy (FA) is reduced in cerebral white matter (WM) of mature ..
  54. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..on CT scan with reduced LV end-diastolic volume, LV stroke volume and cardiac output but not LV-EF on magnetic resonance imaging, particularly among smokers. Furthermore, CT emphysema independently predicted incident HF over 4 years...
  55. Novel neurotrophic therapy in a mouse model of ALS
    Alpaslan Dedeoglu; Fiscal Year: 2013
    ..size, number, dendritic branching, spine density using histopathological, neurochemical techniques and magnetic resonance imaging (MRI) post mortem and in vivo...
  56. Study of Energy and Aging
    Steven Cummings; Fiscal Year: 2009
    ..fat, decreased muscle mass, and decreased maximal aerobic capacity, current studies using conventional magnetic resonance imaging (MRI), computed tomography (CT), performance tests, and circulating biomarkers have not found a clear ..
  57. Effects of Extravasated Serum Proteins on Human Glioblastoma Invasion
    HUNTER REEVE UNDERHILL; Fiscal Year: 2013
    ..This proteomic technique will be coupled with a novel dynamic magnetic resonance imaging (MRI) technique for measuring BBB permeability so that tissues collected for proteomic analysis can be ..
  58. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ..Although brain imaging, such as cranial ultrasound, computed tomography, and magnetic resonance imaging, can document structural brain damage, assessment of infants'endogenously-generated (i.e...
  59. Reactive Oxygen Species Signaling in the Hippocampus
    Eric Klann; Fiscal Year: 2012
    ..these AD model mice exhibited diminished axon transport in vivo, as measured by manganese enhanced magnetic resonance imaging, long-term potentiation (LTP), and impaired hippocampus-dependent memory...
  60. Developmental neurotoxicity of sarin and soman in guinea pigs
    Edson X Albuquerque; Fiscal Year: 2012
    ..b>Magnetic resonance imaging and spectroscopy will be used to identify deviations in brain structure and metabolism...
  61. Plasma RNA based Early Lung Cancer Detection by Tethered Cationic Lipoplex Assay
    SERGE P NANA-SINKAM; Fiscal Year: 2013
    ..a routine pre-screening tool such that more in-depth but also more invasive and expensive mammography or magnetic resonance imaging (MRI) detection methods as well as disease treatment can be conducted as follow-up in early stage of ..
  62. Vascular Consequences of Insulin Resistance and Obesity
    Joseph A Vita; Fiscal Year: 2010
    ..Project 5 (Dr. Hamilton) will use novel magnetic resonance imaging and spectroscopy techniques to test the hypothesis that ectopic lipid deposition is a marker of vascular ..
  63. MRI Biometry of the Pseudophakic Cadaver Eye
    Susan A Strenk; Fiscal Year: 2010
    ..b>Magnetic resonance imaging has the unique ability to fully show the IOL position in the intact eye and will be used to study ..
  64. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..From this work, two quantitative magnetic resonance imaging (MRI) methods have been identified as possible predictors of BBB injury and HT: 1) magnetization ..
  65. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    The goal of this proposal is to develop and evaluate hyperpolarized helium-3 diffusion magnetic resonance imaging (He-3 dMRI) and low dose quantitative computed tomography (LD-QCT) indexes of emphysema as noninvasive biomarkers for the ..
  66. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    ..from the physiologic to the cellular and ultrastructural level using physiologic rat models, novel magnetic resonance imaging techniques, and histologic morphometric and molecular analysis...
  67. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010
    ..responses to various rewards and losses while having their brains scanned by functional Magnetic Resonance Imaging (fMRI)...
  68. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary P Blumberg; Fiscal Year: 2010
    ..of psychiatric diagnosis, illness course features and symptoms, cognitive testing, and multi-modality magnetic resonance imaging brain scanning including functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI)...
  69. A DATABASE OF IOL POSITION AND BEHAVIOR
    Susan A Strenk; Fiscal Year: 2010
    ..b>Magnetic resonance imaging has the unique ability to fully show the IOL position in the intact eye thus providing information to ..
  70. Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Rheal A Towner; Fiscal Year: 2010
    ..Molecular magnetic resonance imaging (mMRI) will be used to assess the nanoprobe specificity for either c-Met or VEGF-R2, and morphological ..
  71. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ..applicant): This proposal describes the development of hyperpolarized-129Xenon (HP-Xe)-based probes for magnetic resonance imaging (MRI) of two biomarkers of inflammation and brain injury, the peripheral benzodiazepine receptor (PBR) ..
  72. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    Revised Abstract: Functional magnetic resonance imaging (fMRI) has become the major tool for examining human brain function in sensory and cognitive neuroscience...
  73. Imaging evidence: Is there competition between marrow fat and bone?
    Wei Shen; Fiscal Year: 2010
    ..Human imaging studies [i.e., magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI) and computed tomography (CT)] have also shown that there is an inverse relationship between bone ..
  74. GE Healthcare Discovery MR750 3T MRI System
    FRANK KOROSEC; Fiscal Year: 2010
    ..of this proposal is to obtain funding to purchase a GE Healthcare Discovery MR750 3T Human Whole-Body Magnetic Resonance Imaging (MRI) system to be installed in the Imaging Sciences Center of a newly-constructed, state-of-the-art ..
  75. Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    Chantal Darquenne; Fiscal Year: 2009
    ..In the last decade, Magnetic Resonance Imaging (MRI) has become a major imaging modality both in clinical medicine and in life science research, and ..
  76. Assessment of Brain Iron and Neuronal Integrity Using Novel T1r and T2r MRI
    Shalom Michaeli; Fiscal Year: 2009
    ..Likewise, magnetic resonance imaging (MRI) in its present state is not useful as a biomarker for PD...
  77. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..Lesion development will be monitored by in vivo magnetic resonance imaging (MRI)...
  78. NEURAL NETWORK MODELING OF SPEECH PRODUCTION
    Frank Guenther; Fiscal Year: 2000
    ..also includes the development of software for producing speaker-specific vocal tract models based on Magnetic Resonance Imaging (MRI) scans...
  79. REGULATION OF CELL FATE IN MUSCULOSKELETAL DEVELOPMENT
    Barbara Wold; Fiscal Year: 1999
    ..cutting edge and developing technologies, the recombinase mediated molecular lineage tracing (RBLT) and magnetic resonance imaging (MRI) for cellular lineage tracing...