diagnostic imaging

Summary

Summary: Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.

Top Publications

  1. ncbi [Imaging nodules within cirrhotic liver: how do I do it?]
    A Luciani
    Service d Imagerie Medicale, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris XII, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    J Radiol 88:1073-90. 2007
  2. ncbi Imaging in the era of molecular oncology
    Ralph Weissleder
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA
    Nature 452:580-9. 2008
  3. ncbi Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging
    Ivo H J Ploemen
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    PLoS ONE 4:e7881. 2009
  4. ncbi Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models
    Tamara Troy
    Xenogen Corporation, USA
    Mol Imaging 3:9-23. 2004
  5. ncbi The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data
    Daniel S Marcus
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Neuroinformatics 5:11-34. 2007
  6. ncbi Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009
  7. ncbi Far-red fluorescent tags for protein imaging in living tissues
    Dmitry Shcherbo
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Miklukho Maklaya 16 10, Moscow, Russia
    Biochem J 418:567-74. 2009
  8. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
  9. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
  10. ncbi A rapidly maturing far-red derivative of DsRed-Express2 for whole-cell labeling
    Rita L Strack
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Biochemistry 48:8279-81. 2009

Research Grants

  1. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert Knight; Fiscal Year: 2009
  2. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
  3. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
  4. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    Bruce Weintraub; Fiscal Year: 2007
  5. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2007
  6. In vivo imaging agents targeting Tau aggregates
    HANK KUNG; Fiscal Year: 2007
  7. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2005
  8. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2010
  9. Preclinical Diagnostic Imaging of Amyloid
    Jonathan Wall; Fiscal Year: 2009
  10. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006

Detail Information

Publications289 found, 100 shown here

  1. ncbi [Imaging nodules within cirrhotic liver: how do I do it?]
    A Luciani
    Service d Imagerie Medicale, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris XII, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    J Radiol 88:1073-90. 2007
    ..The purpose of this paper is to review the imaging features of liver nodules within cirrhotic liver and to propose the imaging strategies when considering the possibility of liver transplantation...
  2. ncbi Imaging in the era of molecular oncology
    Ralph Weissleder
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA
    Nature 452:580-9. 2008
    ....
  3. ncbi Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging
    Ivo H J Ploemen
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    PLoS ONE 4:e7881. 2009
    ....
  4. ncbi Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models
    Tamara Troy
    Xenogen Corporation, USA
    Mol Imaging 3:9-23. 2004
    ..The use of blue-shifted excitation filters is explored as a method to subtract out tissue autofluorescence and improve the sensitivity of fluorescent imaging...
  5. ncbi The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data
    Daniel S Marcus
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Neuroinformatics 5:11-34. 2007
    ..By managing data with XNAT, laboratories are prepared to better maintain the long-term integrity of their data, to explore emergent relations across data types, and to share their data with the broader neuroimaging community...
  6. ncbi Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009
    ..Because their wavelengths penetrate tissue well, IFPs are suitable for whole-body imaging. The IFPs developed here provide a scaffold for further engineering...
  7. ncbi Far-red fluorescent tags for protein imaging in living tissues
    Dmitry Shcherbo
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Miklukho Maklaya 16 10, Moscow, Russia
    Biochem J 418:567-74. 2009
    ..Together, monomeric mKate2 and pseudo-monomeric tdKatushka2 represent the next generation of extra-bright far-red fluorescent probes offering novel possibilities for fluorescent imaging of proteins in living cells and animals...
  8. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
    ..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
  9. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
    ..In vivo imaging showed a 12-fold increase in NIRF signal, allowing the detection of tumors with submillimeter-sized diameters. This strategy can be used to detect such early stage tumors in vivo and to probe for specific enzyme activity...
  10. ncbi A rapidly maturing far-red derivative of DsRed-Express2 for whole-cell labeling
    Rita L Strack
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Biochemistry 48:8279-81. 2009
    ..We show that E2-Crimson has unique applications for flow cytometry and stimulated emission depletion (STED) microscopy...
  11. ncbi Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 18:8220-8. 2010
    ..The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases...
  12. ncbi Noninvasive biophotonic imaging for monitoring of catheter-associated urinary tract infections and therapy in mice
    Jagath L Kadurugamuwa
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, California 94501, USA
    Infect Immun 73:3878-87. 2005
    ....
  13. ncbi Imagable 4T1 model for the study of late stage breast cancer
    Kai Tao
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    BMC Cancer 8:228. 2008
    ..New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported...
  14. ncbi Viral nanoparticles as tools for intravital vascular imaging
    John D Lewis
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:354-60. 2006
    ....
  15. ncbi Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    Jens Duebel
    Department of Biomedical Optics, Max-Planck-Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany
    Neuron 49:81-94. 2006
    ..Blockers of Cl(-) transporters reduced the somatodendritic [Cl(-)](i) gradient. Hence, our results support the idea that ON bipolar cells employ a somatodendritic [Cl(-)](i) gradient to invert GABAergic horizontal cell input...
  16. ncbi Improving lesion-symptom mapping
    Chris Rorden
    Department of Communication Sciences and Disorders, University of South Carolina, SC 29208, USA
    J Cogn Neurosci 19:1081-8. 2007
    ..We also developed software to implement these tests (MRIcron), made freely available to the scientific community...
  17. ncbi Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Angiogenesis 12:17-24. 2009
    ..Furthermore, the current technology might be developed for molecular imaging of other pathophysiological processes...
  18. ncbi Fluorescent peptide probes for in vivo diagnostic imaging
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Biopolymers 76:391-403. 2004
    ..Several of them have been tested in various in vitro and in vivo models, and the obtained imaging information has been applied to disease detection, medical diagnosis, and drug evaluations...
  19. ncbi New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales
    S L Wearne
    Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neuroscience 136:661-80. 2005
    ....
  20. ncbi Beyond phrenology: what can neuroimaging tell us about distributed circuitry?
    Karl Friston
    The Wellcome Department of Cognitive Neurology, University College London, Queen Square, United Kingdom
    Annu Rev Neurosci 25:221-50. 2002
    ..The conclusion, from these sorts of neuroimaging studies, points to the prevalence of top-down influences and the plausibility of generative models of sensory brain function...
  21. ncbi New concepts in synaptic biology derived from single-molecule imaging
    Antoine Triller
    INSERM UR497, Ecole Normale Superieure, Biologie Cellulaire de la Synapse N and P, 46 rue d Ulm, 75005 Paris, France
    Neuron 59:359-74. 2008
    ..In this primer, we will review the different approaches used to track single molecules in live neurons, compare them to bulk measurements, and discuss the different concepts that have emerged from their application to synaptic biology...
  22. ncbi Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging
    Ronald N Germain
    Laboratory of Immunology, Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 221:163-81. 2008
    ..We also describe how the methods we have developed for imaging within lymphoid sites are being applied to other tissues and organs, revealing dynamic details of host-pathogen interactions previously inaccessible to direct observation...
  23. ncbi Imaging of integrin alphavbeta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Metastasis Rev 27:631-44. 2008
    ..The various advantages and disadvantages of several imaging techniques will be discussed in this article...
  24. ncbi Automated image analysis in histopathology: a valuable tool in medical diagnostics
    Laoighse Mulrane
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Rev Mol Diagn 8:707-25. 2008
    ..Reinforced by the phenomenal growth of the virtual pathology field, it is envisioned that the market for automated image analysis tools will greatly expand over the next 10 years...
  25. ncbi Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice
    Zhen Cheng
    Molecular Imaging Program at Stanford (MIPS, Department of Radiology and Bio-X Program, Stanford University, California 94305-5344, USA
    Bioconjug Chem 16:1433-41. 2005
    ..The multmerization of RGD peptide results in moderate improvement of imaging characteristics of the tetramer, compared to that of the monomer and dimeric counterparts...
  26. ncbi Quantification of histochemical staining by color deconvolution
    A C Ruifrok
    Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Anal Quant Cytol Histol 23:291-9. 2001
    ....
  27. ncbi Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction
    Mark J Eisenberg
    Division of Cardiology, Jewish General Hospital, Montreal, Que
    CMAJ 183:430-6. 2011
    ..Patients exposed to low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction may be at increased risk of cancer...
  28. ncbi Deformable models in medical image analysis: a survey
    T McInerney
    Department of Computer Science, University of Toronto, ON, Canada
    Med Image Anal 1:91-108. 1996
    ....
  29. ncbi Diagnostic imaging for low back pain: advice for high-value health care from the American College of Physicians
    Roger Chou
    Oregon Health and Science University, Portland, OR, USA
    Ann Intern Med 154:181-9. 2011
    b>Diagnostic imaging is indicated for patients with low back pain only if they have severe progressive neurologic deficits or signs or symptoms that suggest a serious or specific underlying condition...
  30. ncbi In vivo imaging of light-emitting probes
    B W Rice
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    J Biomed Opt 6:432-40. 2001
    ..Instrumentation for in vivo imaging developed at Xenogen is described and several examples of images of mice with bioluminescent cells are presented...
  31. ncbi Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
    ..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology...
  32. ncbi Use of non-invasive bioluminescent imaging to assess mycobacterial dissemination in mice, treatment with bactericidal drugs and protective immunity
    Frank Heuts
    Department of Microbiology, Karolinska Institute, Box 280, 17177 Stockholm, Sweden
    Microbes Infect 11:1114-21. 2009
    ....
  33. ncbi Non-invasive detection of a small number of bioluminescent cancer cells in vivo
    Jae Beom Kim
    Caliper Life Sciences Inc, Alameda, California, United States of America
    PLoS ONE 5:e9364. 2010
    ..Significantly higher luciferase activity in these cells allowed us to detect micrometastases in both, syngeneic Balb/c and nu/nu mice...
  34. ncbi Imaging ovarian cancer and peritoneal metastases--current and emerging techniques
    Stavroula Kyriazi
    Section of Magnetic Resonance, Cancer Research UK and EPSRC Cancer Imaging Center, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    Nat Rev Clin Oncol 7:381-93. 2010
    ..The combination of functional information with conventional anatomical visualization holds promise to accurately characterize peritoneal disease, and provides noninvasive biomarkers of therapeutic performance and patient prognosis...
  35. ncbi Whole-body imaging with fluorescent proteins
    Robert M Hoffman
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, California 92111, USA
    Nat Protoc 1:1429-38. 2006
    ..Fluorescent protein-based imaging technology can be used for whole-body imaging of fluorescent cells on essentially all organs. The timeline for these experiments varies from 2 days to 2 months...
  36. ncbi Brain tumor imaging in clinical trials
    J W Henson
    Stephen E and Catherine Pappas Brain Tumor Imaging Research Program, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 29:419-24. 2008
    ....
  37. ncbi Core-shell silica nanoparticles as fluorescent labels for nanomedicine
    Jinhyang Choi
    Cornell University, Department of Biomedical Sciences, Ithaca, New York 14853, USA
    J Biomed Opt 12:064007. 2007
    ..These results demonstrate that fluorescent core-shell silica nanoparticles represent a powerful novel imaging tool within the emerging field of nanomedicine...
  38. ncbi In vivo bioluminescence imaging for integrated studies of infection
    Timothy C Doyle
    Molecular Imaging Program at Stanford (MIPS, Clark Center, Bio-X Program, 318 Campus Drive, Room E-150, Stanford University School of Medicine, Stanford, CA 94305-5427, USA
    Cell Microbiol 6:303-17. 2004
    ....
  39. ncbi Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons
    Keizo Takao
    RIKEN-Massachusetts Institute of Technology (MIT) Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
    J Neurosci 25:3107-12. 2005
    ..In combination with two-photon microscopy, we demonstrate that Camuialpha can be used to observe temporal and spatial regulation of CaMKII activity in living neurons...
  40. ncbi Development and evaluation of the virtual pathology slide: a new tool in telepathology
    Sean S P Costello
    School of Biotechnology, Medical Informatics Group, Dublin City University, Dublin, Ireland
    J Med Internet Res 5:e11. 2003
    ..CONCLUSIONS: Results from this study show that the Virtual Pathology Slide can be used to make a correct diagnostic decision, and that the system is a realistic alternative to dynamic telepathology...
  41. ncbi Radiogenomics: creating a link between molecular diagnostics and diagnostic imaging
    Aaron M Rutman
    Department of Radiology, University of California San Diego Medical Center, San Diego, CA 92103, USA
    Eur J Radiol 70:232-41. 2009
    ..quot; These findings underline a potential future role of both diagnostic and interventional radiologists in genetic assessment of cancer patients with radiographic imaging studies...
  42. ncbi Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    Anal Chem 78:5925-32. 2006
    ..g., fluorescent imaging and functional magnetic resonance imaging)...
  43. ncbi A review of methods for quantitative evaluation of spinal curvature
    Tomaz Vrtovec
    Laboratory of Imaging Technologies, Faculty of Electrical Engineering, University of Ljubljana, Trzaska cesta 25, 1000, Ljubljana, Slovenia
    Eur Spine J 18:593-607. 2009
    ..Key evaluation issues and future considerations, supported by the results of the overview, are also discussed...
  44. ncbi Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?
    Susanne Bonekamp
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Hepatol 50:17-35. 2009
    ..However, to date only magnetic resonance elastography has been able to stage fibrosis or diagnose mild disease. Utrasonographic elastography and magnetic resonance diffusion weighted appear next most promising...
  45. ncbi The potential Salmonella aroA- vaccine strain is safe and effective in young BALB/c mice
    Stacy M Burns-Guydish
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Neonatology 91:114-20. 2007
    ..Due to the increased susceptibility of neonates to pathogens including those with mutations, the use of live vaccine strategies in the human population may present a potential risk to the young...
  46. ncbi Different styles of image-guided radiotherapy
    Marcel van Herk
    Radiotherapy Department, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Semin Radiat Oncol 17:258-67. 2007
    ..We can conclude that image-guided radiotherapy is very much a clinical reality and that the development of optimal clinical protocols should currently be the focus of research...
  47. ncbi Diagnostic imaging in the management of craniosynostoses
    Bibiana Kotrikova
    Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Eur Radiol 17:1968-78. 2007
    ..In the present review we will describe the most important clinical and radiological characteristics of craniosynostosis by means of clinical, radiological and operative situs examples...
  48. ncbi Cell-based therapies and imaging in cardiology
    Frank M Bengel
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munich, Germany
    Eur J Nucl Med Mol Imaging 32:S404-16. 2005
    ..Integration of cell imaging into studies of cardiac cell therapy holds promise to facilitate further growth of the field towards a broadly clinically useful application...
  49. ncbi Form to function: current and future roles for atherosclerosis imaging in drug development
    Alistair C Lindsay
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Nat Rev Drug Discov 7:517-29. 2008
    ..We consider how emerging molecular and cellular imaging techniques could offer the possibility to quantify changes in biological function at the level of the plaque, even without gross structural change...
  50. ncbi Identifying prostate carcinoma by MALDI-Imaging
    Kristina Schwamborn
    Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
    Int J Mol Med 20:155-9. 2007
    ....
  51. ncbi A developmental and genetic classification for malformations of cortical development
    A J Barkovich
    Department of Radiology, University of California, San Francisco, CA, USA
    Neurology 65:1873-87. 2005
    ..This classification allows a better conceptual understanding of the disorders, and the use of neuroimaging characteristics allows it to be applied to all patients without necessitating brain biopsy, as in pathology-based classifications...
  52. ncbi Use of new imaging techniques to predict tumour response to therapy
    Vanessa N Harry
    Department of Gynaecological Oncology, St Bartholomew s Hospital, London, UK
    Lancet Oncol 11:92-102. 2010
    ....
  53. ncbi Non-invasive imaging of GFAP expression after neuronal damage in mice
    Lingyun Zhu
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    Neurosci Lett 367:210-2. 2004
    ....
  54. ncbi Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II)
    L Norgren
    Department of Surgery, University Hospital, Orebro, Sweden
    Eur J Vasc Endovasc Surg 33:S1-75. 2007
  55. ncbi In vivo bioluminescence imaging
    Akiko Sato
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305-5410, USA
    Comp Med 54:631-4. 2004
    ....
  56. ncbi Multifunctional dendrimer-modified multiwalled carbon nanotubes: synthesis, characterization, and in vitro cancer cell targeting and imaging
    Xiangyang Shi
    NanoBiotechnology Laboratory, College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai 201620, People s Republic of China
    Biomacromolecules 10:1744-50. 2009
    ....
  57. ncbi Luminescent quantum dots for multiplexed biological detection and imaging
    Warren C W Chan
    Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA
    Curr Opin Biotechnol 13:40-6. 2002
    ..These novel optical properties render quantum dots ideal fluorophores for ultrasensitive, multicolor, and multiplexing applications in molecular biotechnology and bioengineering...
  58. ncbi Localized recrudescence of Toxoplasma infections in the central nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging
    Isabel Dellacasa Lindberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Microbes Infect 9:1291-8. 2007
    ..Collectively, the findings suggest that the localization of reactivation foci in the CNS, in conjunction with immune responses, influences the outcome of acute reactivated Toxoplasma encephalitis...
  59. ncbi Texture analysis of medical images
    G Castellano
    Neuroimage Laboratory, Faculty of Medical Sciences, State University of Campinas, Brazil
    Clin Radiol 59:1061-9. 2004
    ..In this article we clarify the principles of texture analysis and give examples of its applications, reviewing studies of the technique...
  60. ncbi Imaging matrix metalloproteinases in cancer
    Randy L Scherer
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Metastasis Rev 27:679-90. 2008
    ..This review draws attention to a variety of strategies utilized to image MMP activity in vivo...
  61. ncbi Clinics in diagnostic imaging (134). Testicular lymphoma
    T Srisuwan
    Department of Radiology, Chiang Mai University, 110 Intavaroros Road, Amphoe Muang, Chiang Mai 50200, Thailand
    Singapore Med J 52:204-8. 2011
    ..No evidence of lymphoma in other organs was demonstrated. We discuss the differential diagnosis of ultrasonographic intratesticular masses and highlight various cases of intratesticular lesions in this article...
  62. ncbi Bending the curve: the recent marked slowdown in growth of noninvasive diagnostic imaging
    David C Levin
    Center for Research on Utilization of Imaging Services, Department of Radiology, Thomas Jefferson University Hospital and Jefferson Medical College, 132 S 10th St, Main 1090, Philadelphia, PA 19107, USA
    AJR Am J Roentgenol 196:W25-9. 2011
    The purpose of this article is to determine whether there has been any change in the rapid growth pattern that has characterized noninvasive diagnostic imaging in recent years.
  63. ncbi Practice patterns of radiologists and nonradiologists in utilization of noninvasive diagnostic imaging among the Medicare population 1993-1999
    Andrea J Maitino
    Department of Radiology, Thomas Jefferson University, Suite 3390, Gibbon Bldg, 111 S 11th St, Philadelphia, PA 19107, USA
    Radiology 228:795-801. 2003
    To compare nationwide trends in noninvasive diagnostic imaging (NDI) practice patterns of radiologists and of nonradiologists among the Medicare population during the 6 years from 1993 to 1999.
  64. ncbi Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Opt Lett 34:2566-8. 2009
    ..The method holds great promise for artifact-free whole-body visualization of optical molecular probes...
  65. ncbi Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers
    Mary E Caldorera-Moore
    Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
    Acc Chem Res 44:1061-70. 2011
    ..This Account explores recent advances in the field of nanotheranostics and the various fundamental components of an effective theranostic carrier...
  66. ncbi Multimodality image registration by maximization of mutual information
    F Maes
    Laboratory for Medical Imaging Research, Katholieke Universiteit Leuven, Universitair Ziekenhuis Gasthuisberg, Belgium
    IEEE Trans Med Imaging 16:187-98. 1997
    ....
  67. ncbi Diagnostic imaging in acute disseminated encephalomyelitis
    Vesna V Brinar
    University of Zagreb, School of Medicine and University Hospital Centre Zagreb, Department of Neurology and Referral Center for Demyelinating Diseases of the Central Nervous System, Zagreb, Croatia
    Expert Rev Neurother 10:459-67. 2010
    ..This review will summarize clinical and paraclinical characteristics of acute disseminated encephalomyelitis in adults, with special emphasis on diagnostic imaging.
  68. ncbi Spatiotemporal progression of localized bacterial peritonitis before and after open abdomen lavage monitored by in vivo bioluminescent imaging
    Prashant K Sharma
    Department of Biomedical Engineering, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Surgery 147:89-97. 2010
    ..Our objective was to develop a noninvasive in vivo imaging technique to monitor the spatiotemporal spread of bacterial peritonitis...
  69. ncbi Molecular imaging in atherosclerosis, thrombosis, and vascular inflammation
    Robin P Choudhury
    Department of Cardiovascular Medicine, University of Oxford, UK
    Arterioscler Thromb Vasc Biol 29:983-91. 2009
    ..We address the potential and limitations of current contrast approaches in respect of translation to clinically usable agents and speculate on future applications...
  70. ncbi Socioeconomic status and the utilization of diagnostic imaging in an urban setting
    Sandor Demeter
    Radiology and Diagnostic Imaging, University of Manitoba, Winnipeg, Man
    CMAJ 173:1173-7. 2005
    ..between SES and health care utilization has been examined in Canada relative to surgical, cardiac and preventive health care services, no published studies have specifically explored the association between SES and diagnostic imaging.
  71. ncbi Diagnostic imaging in nontraumatic pediatric head and neck emergencies
    Benjamin J Ludwig
    Department of Radiology, Boston University Medical Center, Boston University School of Medicine, 820 Harrison Ave, FGH Bldg, 3rd Floor, Boston, MA 02118, USA
    Radiographics 30:781-99. 2010
    ..In especially difficult or complex cases, magnetic resonance imaging may offer additional detail with respect to the extent of disease...
  72. ncbi Multiple image watermarking applied to health information management
    Aggeliki Giakoumaki
    Biomedical Engineering Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece
    IEEE Trans Inf Technol Biomed 10:722-32. 2006
    ..Experimental results indicate the efficiency and transparency of the scheme, which conforms to the strict requirements that apply to regions of diagnostic significance...
  73. ncbi Rat lumbar vertebrae bone densitometry using multidetector CT
    Yi Xiang J Wang
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Eur Radiol 19:882-90. 2009
    ..7 +/- 6.7% BMD reduction at 28 days. Clinical MDCT can reliably and accurately measure rat lumbar vertebral BMD and is much faster than pQCT...
  74. ncbi Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model
    Michael Bouvet
    Department of Surgery, University of California San Diego, San Diego, California 92161, USA
    Cancer Res 62:1534-40. 2002
    ..The GFP imaging technology presented in this report will facilitate studies of modulators of pancreatic cancer growth, including inhibition by potential chemotherapeutic agents...
  75. ncbi Clinics in diagnostic imaging (128). Portal pyaemia
    E M Y Chia
    Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Road, Singapore
    Singapore Med J 50:1023-8; quiz 1029. 2009
    ..The mortality rate of patients with portal venous gas depends on the underlying cause. The high mortality rate of patients with portal venous gas due to bowel necrosis or ischaemia may necessitate emergent surgical intervention...
  76. ncbi Timely follow-up of abnormal diagnostic imaging test results in an outpatient setting: are electronic medical records achieving their potential?
    Hardeep Singh
    Department of Veterans Affairs Health Services Research and Development Service, Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Arch Intern Med 169:1578-86. 2009
    Given the fragmentation of outpatient care, timely follow-up of abnormal diagnostic imaging results remains a challenge...
  77. ncbi Bone matrix imaged in vivo by water- and fat-suppressed proton projection MRI (WASPI) of animal and human subjects
    Yaotang Wu
    Department of Orthopaedic Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 31:954-63. 2010
    ..To demonstrate water- and fat-suppressed proton projection MRI (WASPI) in a clinical scanner to visualize the solid bone matrix in animal and human subjects...
  78. ncbi Efficiency of a semiautomated coding and review process for notification of critical findings in diagnostic imaging
    Vaishali R Choksi
    Department of Veterans Affairs, Ann Arbor VA Healthcare System, Ann Arbor, MI 48109, USA
    AJR Am J Roentgenol 186:933-6. 2006
    ..On the basis of prior root cause analysis, we developed and instituted a semiautomated process for notification of critical diagnostic imaging findings. We now report our 12-month experience with the process.
  79. ncbi A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation
    Waqar Ahmad
    Applied and Functional Genomics Laboratory, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:53. 2011
    ....
  80. ncbi Rough sets and near sets in medical imaging: a review
    Aboul Ella Hassanien
    Information Technology Department, Faculty of Computers and Information FCI, Cairo University, 12613, Orman, Giza, Egypt
    IEEE Trans Inf Technol Biomed 13:955-68. 2009
    ..Challenges to be addressed and future directions of research are identified and an extensive bibliography is also included...
  81. ncbi Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light
    Soren D Konecky
    Laser Microbeam and Medical Program LAMMP, Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA
    Opt Express 17:14780-90. 2009
    ..The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements...
  82. ncbi Improved diagnostic imaging and interventional therapies prolong survival after resection for hepatocellular carcinoma in cirrhosis: the university of bologna experience over 10 years
    Alessandro Cucchetti
    Liver and Multiorgan Transplant Unit, Policlinico Sant Orsola Malpighi, University of Bologna, Bologna, Italy
    Ann Surg Oncol 18:1630-7. 2011
    ....
  83. ncbi Semi-automated imaging system to quantitate estrogen and progesterone receptor immunoreactivity in human breast cancer
    G M Sharangpani
    BioImagene, Inc, 1601 S De Anza Blvd, Suite 212, Cupertino, California, USA
    J Microsc 226:244-55. 2007
    ..Because of all these properties, our semi-automated imaging system 'adds value' as a means of measuring these important nuclear biomarkers of human breast cancer...
  84. ncbi Abdominal manifestations of cystic fibrosis in children
    Gulraiz Chaudry
    Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Pediatr Radiol 36:233-40. 2006
    ..We present a pictorial review of the radiological appearance of these abdominal manifestations. The conditions are dealt with individually, together with typical appearances in various imaging modalities...
  85. ncbi Childhood pancreatitis
    Andy Nydegger
    Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Victoria, Australia
    J Gastroenterol Hepatol 21:499-509. 2006
    ..Herein is provided a review for the reader with particular emphasis on some of these newer advances...
  86. ncbi Tamper detection and recovery for medical images using near-lossless information hiding technique
    Jeffery H K Wu
    Department of Medical Imaging, Chang Hua Christian Hospital, Changhua, Taiwan
    J Digit Imaging 21:59-76. 2008
    ..With the proposal method, any random changes on the stego image will be detected in high probability...
  87. ncbi Intravital imaging of cell movement in tumours
    John Condeelis
    Department of Anatomy and Structural Biology, Program in Motility and Invasion, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Rev Cancer 3:921-30. 2003
  88. ncbi Imaging hepatobiliary disease in children
    Lisa H Lowe
    University of Missouri-Kansas City, Department of Radiology, Children's Mercy Hospital and Clinics, Kansas City, Missouri 64108, USA
    Semin Roentgenol 43:39-49. 2008
  89. ncbi New frontiers in diagnostic imaging in concussive head injury
    K M Johnston
    Department of Neurosurgery, McGill University, Montreal, Quebec, Canada
    Clin J Sport Med 11:166-75. 2001
    ..In this paper, we explore new techniques in the neuroimaging of concussion including diffusion-weighted magnetic resonance imaging and functional brain imaging technology...
  90. ncbi Synthesis of target-specific radiolabeled peptides for diagnostic imaging
    Jakub Fichna
    Department of Medicinal Chemistry, Medical University of Lodz, Lindleya 6, 90-131 Lodz, Poland
    Bioconjug Chem 14:3-17. 2003
  91. ncbi Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents
    Siouxsie Wiles
    Division of Cell and Molecular Biology, Natural Sciences, Imperial College London, London SW7 2AZ, UK
    Lab Anim 41:321-8. 2007
    ..The data presented suggest that this technology is ideal for use as a teaching aid and may also prove valuable in assessing the effectiveness of 'complex' and novel administration routes in 'realtime'...
  92. ncbi A quantitative study of factors affecting in vivo bioluminescence imaging
    Kemi Cui
    Department of Radiology, The Methodist Hospital, Weill Cornell University, Houston, TX 77030, USA
    Luminescence 23:292-5. 2008
    ..The data indicate that a carefully designed BLI experiment is required to generate optimal and consistent results...
  93. ncbi A review of cranial imaging techniques: potential and limitations
    Rudolf Fahlbusch
    International Neurosciences Institute, Hannover, Germany
    Clin Neurosurg 54:100-4. 2007
  94. ncbi Image registration: an essential tool for nuclear medicine
    Brian F Hutton
    Department of Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, Australia
    Eur J Nucl Med Mol Imaging 29:559-77. 2002
    ..The alternative is to install a dual-modality instrument. The objective of this review is to present a general overview of medical image registration with emphasis on the application and issues relevant to nuclear medicine...
  95. ncbi Tumors and tumor-like lesions of the neck: from childhood to adult
    H Imhof
    Abteilung fuer Osteologie, Universitaetsklinik fuer Radiodiagnostik, AKH Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur Radiol 14:L155-65. 2004
    ..The most common malignant tumors in the head and neck region are lymphomas and rhabdomyosarcomas. Lymph node enlargements, reactive or/and infectious, account also for a significant amount of cervical masses...
  96. ncbi Neuroimaging of attention deficit hyperactivity disorder: can new imaging findings be integrated in clinical practice?
    George Bush
    Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Child Adolesc Psychiatr Clin N Am 17:385-404, x. 2008
    ....
  97. ncbi F-information measures in medical image registration
    Josien P W Pluim
    Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    IEEE Trans Med Imaging 23:1508-16. 2004
    ..An important finding, however, is that several measures, although slightly more difficult to optimize, can potentially yield significantly more accurate results than mutual information...
  98. ncbi Imaging in epilepsy
    T M Salmenpera
    The MRI Unit, The National Society for Epilepsy and the Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, University College London, UK
    J Neurol Neurosurg Psychiatry 76:iii2-iii10. 2005
  99. ncbi [Extra-medullary hematopoiesis: imaging findings]
    M Teufel
    Rofo 180:775-80. 2008
  100. ncbi Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives
    James P B O'Connor
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
    Lancet Oncol 9:766-76. 2008
    ....
  101. ncbi [Parametric biomedical imaging--what defines the quality of quantitative radiological approaches?]
    C C Gluer
    Medizinische Physik, Klinik für Diagnostische Radiologie, Universitatsklinikum Schleswig Holstein, Kiel
    Rofo 178:1187-201. 2006
    ....

Research Grants76

  1. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert Knight; Fiscal Year: 2009
    ..for tPA treatment of ischemic stroke is time (3 hr post-ictus and CT exam negative for bleeding, as no diagnostic imaging indicators are available for excluding high-risk stroke patients...
  2. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..Remarkably few studies have compared the effectiveness of expensive imaging technologies. Studies comparing diagnostic imaging tests must include not only an assessment of diagnostic accuracy, but also a range of outcomes including ..
  3. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..for tPA treatment of ischemic stroke is time (3 hr post-ictus and CT exam negative for bleeding, as no diagnostic imaging indicators are available for excluding high-risk stroke patients...
  4. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    Bruce Weintraub; Fiscal Year: 2007
    ..both co-inventor and co-developer with Genzyme of wild type recombinant human TSH, currently approved for diagnostic imaging of thyroid cancer, now proposes to develop novel 123I or 125I-labeled high affinity TSH analogs for imaging ..
  5. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2007
    The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical! diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," the real ..
  6. In vivo imaging agents targeting Tau aggregates
    HANK KUNG; Fiscal Year: 2007
    ..The objective of this project is to develop potential F-18 and I-123 labeled diagnostic imaging agents, which specifically detect tangles (tau aggregates) in the brain using positron emission tomography (..
  7. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2005
    ..He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality...
  8. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2010
    ....
  9. Preclinical Diagnostic Imaging of Amyloid
    Jonathan Wall; Fiscal Year: 2009
    ....
  10. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    b>Diagnostic imaging requires the sufficient intensity of a corresponding signal from an area of interest in order to obtain diagnostically significant images...
  11. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  12. Development of Thermoacoustic Tomography Brain Imaging
    Mark A Anastasio; Fiscal Year: 2010
    ..is a rapidly emerging ultrasound-mediated hybrid imaging modality that promises to have a major impact on diagnostic imaging. TAT combines high ultrasonic resolution and strong microwave contrast in a single hybrid modality...
  13. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1993
    ....
  14. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward H Wong; Fiscal Year: 2010
    ..second generation of cross-bridged chelators for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer...
  15. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2009
    ..second generation of cross-bridged chelators for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer...
  16. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2007
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  17. Automated Radiation Monitoring and Decision Support to Reduce Cumulative Exposure
    Aaron Sodickson; Fiscal Year: 2010
    ..Rapidly increasing utilization of diagnostic imaging - and in particular computed tomography (CT) - has markedly increased radiation exposure to the population, ..
  18. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 1999
    ..The hypothesis of this proposal is that optical coherence tomography, a new optical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  19. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2003
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  20. Multispectral diagnostic imaging of the iris
    ANA LUKIC; Fiscal Year: 2007
    The objective of this project is to develop a prototype of a new diagnostic imaging device for use by eye care practitioners...