diagnostic imaging

Summary

Summary: Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.

Top Publications

  1. ncbi Whole-body imaging with fluorescent proteins
    Robert M Hoffman
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, California 92111, USA
    Nat Protoc 1:1429-38. 2006
  2. ncbi In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice
    M Almajdub
    ANIMAGE, Rhône Alpes GENOPOLE, Universite de Lyon, Bât CERMEP 59, boulevard Pinel, 69677 Bron Cedex, France
    Contrast Media Mol Imaging 2:88-93. 2007
  3. ncbi Improving lesion-symptom mapping
    Chris Rorden
    Department of Communication Sciences and Disorders, University of South Carolina, SC 29208, USA
    J Cogn Neurosci 19:1081-8. 2007
  4. ncbi Localized recrudescence of Toxoplasma infections in the central nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging
    Isabel Dellacasa-Lindberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Microbes Infect 9:1291-8. 2007
  5. ncbi Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    Jens Duebel
    Department of Biomedical Optics, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 49:81-94. 2006
  6. pmc Quantum dots for live cells, in vivo imaging, and diagnostics
    X Michalet
    Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 307:538-44. 2005
  7. pmc Imaging in the era of molecular oncology
    Ralph Weissleder
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA
    Nature 452:580-9. 2008
  8. pmc Far-red fluorescent tags for protein imaging in living tissues
    Dmitry Shcherbo
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Miklukho Maklaya 16 10, Moscow, Russia
    Biochem J 418:567-74. 2009
  9. ncbi Shedding light onto live molecular targets
    Ralph Weissleder
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 9:123-8. 2003
  10. pmc Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009

Detail Information

Publications382 found, 100 shown here

  1. ncbi Whole-body imaging with fluorescent proteins
    Robert M Hoffman
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, California 92111, USA
    Nat Protoc 1:1429-38. 2006
    ..Fluorescent protein-based imaging technology can be used for whole-body imaging of fluorescent cells on essentially all organs. The timeline for these experiments varies from 2 days to 2 months...
  2. ncbi In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice
    M Almajdub
    ANIMAGE, Rhône Alpes GENOPOLE, Universite de Lyon, Bât CERMEP 59, boulevard Pinel, 69677 Bron Cedex, France
    Contrast Media Mol Imaging 2:88-93. 2007
    ..3 mm in diameter. High-resolution X-ray micro-CT in living mice using DHOG contrast agent allowed visualization and volume quantification of normal spleen and of spleen tumor and its liver metastases...
  3. ncbi Improving lesion-symptom mapping
    Chris Rorden
    Department of Communication Sciences and Disorders, University of South Carolina, SC 29208, USA
    J Cogn Neurosci 19:1081-8. 2007
    ..We also developed software to implement these tests (MRIcron), made freely available to the scientific community...
  4. ncbi Localized recrudescence of Toxoplasma infections in the central nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging
    Isabel Dellacasa-Lindberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Microbes Infect 9:1291-8. 2007
    ..Collectively, the findings suggest that the localization of reactivation foci in the CNS, in conjunction with immune responses, influences the outcome of acute reactivated Toxoplasma encephalitis...
  5. ncbi Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    Jens Duebel
    Department of Biomedical Optics, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 49:81-94. 2006
    ..Blockers of Cl(-) transporters reduced the somatodendritic [Cl(-)](i) gradient. Hence, our results support the idea that ON bipolar cells employ a somatodendritic [Cl(-)](i) gradient to invert GABAergic horizontal cell input...
  6. pmc Quantum dots for live cells, in vivo imaging, and diagnostics
    X Michalet
    Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 307:538-44. 2005
    ....
  7. pmc Imaging in the era of molecular oncology
    Ralph Weissleder
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA
    Nature 452:580-9. 2008
    ....
  8. pmc Far-red fluorescent tags for protein imaging in living tissues
    Dmitry Shcherbo
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Miklukho Maklaya 16 10, Moscow, Russia
    Biochem J 418:567-74. 2009
    ..Together, monomeric mKate2 and pseudo-monomeric tdKatushka2 represent the next generation of extra-bright far-red fluorescent probes offering novel possibilities for fluorescent imaging of proteins in living cells and animals...
  9. ncbi Shedding light onto live molecular targets
    Ralph Weissleder
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 9:123-8. 2003
  10. pmc Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009
    ..Because their wavelengths penetrate tissue well, IFPs are suitable for whole-body imaging. The IFPs developed here provide a scaffold for further engineering...
  11. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
    ..In vivo imaging showed a 12-fold increase in NIRF signal, allowing the detection of tumors with submillimeter-sized diameters. This strategy can be used to detect such early stage tumors in vivo and to probe for specific enzyme activity...
  12. pmc Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats
    Michelle Longmire
    Molecular Imaging Program, NCI NIH Building 10, Bethesda, MD 20892 1088, USA
    Nanomedicine (Lond) 3:703-17. 2008
    Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities...
  13. ncbi Luminescent quantum dots for multiplexed biological detection and imaging
    Warren C W Chan
    Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA
    Curr Opin Biotechnol 13:40-6. 2002
    ..These novel optical properties render quantum dots ideal fluorophores for ultrasensitive, multicolor, and multiplexing applications in molecular biotechnology and bioengineering...
  14. ncbi Magnetic resonance electrical impedance tomography (MREIT) for high-resolution conductivity imaging
    Eung Je Woo
    Department of Biomedical Engineering, Kyung Hee University, Korea
    Physiol Meas 29:R1-26. 2008
    ..Suggestions for future research directions, possible applications in biomedicine, biology, chemistry and material science are discussed...
  15. pmc Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging
    Ivo H J Ploemen
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    PLoS ONE 4:e7881. 2009
    ....
  16. ncbi Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors
    Liqin Xiong
    Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, PR China
    Biomaterials 31:7078-85. 2010
    ..The study suggests that PAA-UNCPs can potentially be used for long-term targeted imaging and therapy studies in vivo...
  17. pmc Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods
    Jesse V Jokerst
    Molecular Imaging Program at Stanford, Department of Radiology, 318 Campus Drive, Stanford University, Stanford, California 94305 5427, United States
    ACS Nano 6:5920-30. 2012
    ..This approach has significant advantages over traditional cell imaging techniques like positron emission tomography and magnetic resonance imaging including real time monitoring of stem cell therapy...
  18. pmc In vitro and in vivo two-photon luminescence imaging of single gold nanorods
    Haifeng Wang
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:15752-6. 2005
    ..The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels...
  19. pmc Non-invasive detection of a small number of bioluminescent cancer cells in vivo
    Jae Beom Kim
    Caliper Life Sciences Inc, Alameda, California, United States of America
    PLoS ONE 5:e9364. 2010
    ..Significantly higher luciferase activity in these cells allowed us to detect micrometastases in both, syngeneic Balb/c and nu/nu mice...
  20. ncbi Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models
    Tamara Troy
    Xenogen Corporation, USA
    Mol Imaging 3:9-23. 2004
    ..The use of blue-shifted excitation filters is explored as a method to subtract out tissue autofluorescence and improve the sensitivity of fluorescent imaging...
  21. ncbi In vivo imaging of light-emitting probes
    B W Rice
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    J Biomed Opt 6:432-40. 2001
    ..Instrumentation for in vivo imaging developed at Xenogen is described and several examples of images of mice with bioluminescent cells are presented...
  22. pmc A rapidly maturing far-red derivative of DsRed-Express2 for whole-cell labeling
    Rita L Strack
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Biochemistry 48:8279-81. 2009
    ..We show that E2-Crimson has unique applications for flow cytometry and stimulated emission depletion (STED) microscopy...
  23. ncbi Radiation dose to patients from cardiac diagnostic imaging
    Andrew J Einstein
    Department of Medicine, Cardiology Division, Columbia University Medical Center, 622 W 168th St, PH 10 408, New York, NY 10032, USA
    Circulation 116:1290-305. 2007
  24. ncbi Self-illuminating quantum dot conjugates for in vivo imaging
    Min Kyung So
    Molecular Imaging Program, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, California 94305 5484, USA
    Nat Biotechnol 24:339-43. 2006
    ..Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10(3) for 5 pmol of conjugate...
  25. ncbi RECIST revisited: a review of validation studies on tumour assessment
    P Therasse
    EORTC Data Center, avenue E Mounier, 83 Box 11, 1200 Brussels, Belgium
    Eur J Cancer 42:1031-9. 2006
    ..The findings of this review, together with experience acquired thus far and the results of some ongoing research projects, have paved the way for RECIST 2.0 to be hopefully announced later this year...
  26. pmc Development and applications of photo-triggered theranostic agents
    Prakash Rai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, United States
    Adv Drug Deliv Rev 62:1094-124. 2010
    ..Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases...
  27. ncbi The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data
    Daniel S Marcus
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Neuroinformatics 5:11-34. 2007
    ..By managing data with XNAT, laboratories are prepared to better maintain the long-term integrity of their data, to explore emergent relations across data types, and to share their data with the broader neuroimaging community...
  28. ncbi Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  29. ncbi Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:041102. 2006
    ..This review is an attempt to indicate which sets of phantoms are optimal for specific applications, and provide links to studies that characterize main phantom material properties and recipes...
  30. ncbi The new era of medical imaging--progress and pitfalls
    John K Iglehart
    N Engl J Med 354:2822-8. 2006
  31. ncbi Radiologic and nuclear medicine studies in the United States and worldwide: frequency, radiation dose, and comparison with other radiation sources--1950-2007
    Fred A Mettler
    Radiology and Nuclear Medicine Service, New Mexico VA Health Care System, 1501 San Pedro Blvd SE, Albuquerque, NM 87108, USA
    Radiology 253:520-31. 2009
    ..Worldwide, the average annual per-capita effective dose from medicine (about 0.6 mSv of the total 3.0 mSv received from all sources) has approximately doubled in the past 10-15 years...
  32. pmc Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents
    Renu John
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
    Mol Imaging Biol 14:17-24. 2012
    ..The development, characterization, and use of multifunctional multimodal microspheres are described for targeted contrast and therapeutic applications...
  33. pmc Informatics in radiology: what can you see in a single glance and how might this guide visual search in medical images?
    Trafton Drew
    Visual Attention Laboratory, Department of Surgery, Brigham and Women s Hospital, 64 Sidney St, Suite 170, Cambridge, MA 02139 4170, USA
    Radiographics 33:263-74. 2013
    ....
  34. pmc Timely follow-up of abnormal diagnostic imaging test results in an outpatient setting: are electronic medical records achieving their potential?
    Hardeep Singh
    Department of Veterans Affairs Health Services Research and Development Service, Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Arch Intern Med 169:1578-86. 2009
    Given the fragmentation of outpatient care, timely follow-up of abnormal diagnostic imaging results remains a challenge...
  35. ncbi (⁹⁹m)Tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging
    Rafael Torres Martin De Rosales
    Division of Imaging Sciences and Biomedical Engineering, King s College London, Thomas Hospital, London, UK
    Bioconjug Chem 22:455-65. 2011
    ....
  36. pmc Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
    ..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology...
  37. ncbi Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging
    Teng Luo
    School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
    Opt Express 19:17030-9. 2011
    ..The dual mode imaging probe has great potential for use in applications such as cancer targeting, molecular imaging in combination with radiotherapy, and photothermolysis...
  38. ncbi X-space MPI: magnetic nanoparticles for safe medical imaging
    Patrick William Goodwill
    Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720 1762, USA
    Adv Mater 24:3870-7. 2012
    ..X-space MPI theory predicts that larger nanoparticles could enable up to 250 micrometer resolution imaging, which would represent a major breakthrough in safe imaging for CKD patients...
  39. pmc Evaluation of immunity against malaria using luciferase-expressing Plasmodium berghei parasites
    Ivo Ploemen
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center RUNMC, Nijmegen, The Netherlands
    Malar J 10:350. 2011
    ..This study explores the benefit of using these parasites for the evaluation of immunity against malaria, compared to qRT-PCR techniques in vivo and in vitro...
  40. ncbi Real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging: preliminary results of a prospective study
    Naoyuki Yokoyama
    Department of Digestive Surgery, Niigata City General Hospital, Niigata, Japan
    Cancer 118:2813-9. 2012
    ..The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer...
  41. ncbi Mass spectrometry imaging for drug distribution studies
    Brendan Prideaux
    Novartis Institutes for BioMedical Research, Basel, Switzerland Public Health Research Institute, Newark, NJ 07103, USA
    J Proteomics 75:4999-5013. 2012
    ..In this article we review the different MSI technologies that have been applied to the imaging of pharmaceuticals. Recent technical advances, applications and current analytical limitations are discussed...
  42. pmc Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression
    Joeri Kuil
    Division of Diagnostic Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands
    Mol Pharm 8:2444-53. 2011
    ..Thus, multimerization of the cyclic Ac-TZ14011 peptide reduces the negative influence of the multimodal label on the receptor affinity and the biodistribution...
  43. ncbi Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging
    Qianjun He
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
    Biomaterials 33:4392-402. 2012
    ....
  44. pmc Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging
    Praveen D Chowdary
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 70:9562-9. 2010
    ..By optimizing optical sources and beam delivery, this technique can potentially enable real-time point-of-care optical molecular imaging and diagnosis...
  45. ncbi Optical imaging: current applications and future directions
    Gary D Luker
    University of Michigan, Ann Arbor, Michigan, USA
    J Nucl Med 49:1-4. 2008
    ..In this review, we summarize recent advances in optical techniques for molecular imaging and the potential impact for clinical medicine...
  46. pmc Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle
    Nobuyuki Kosaka
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 1088, USA
    Contrast Media Mol Imaging 6:55-9. 2011
    ..These advantages of BRET-QDot allowed us to perform real-time, quantitative lymphatic imaging without image processing. BRET-Qdots have the potential to be a robust nano-material platform for developing optical molecular imaging probes...
  47. ncbi Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives
    Megan A Hahn
    Particle Engineering Research Center, University of Florida, 205 Particle Science and Technology Building, P O Box 116135, Gainesville, FL 32611, USA
    Anal Bioanal Chem 399:3-27. 2011
    ..Emerging technologies, for example multifunctional and theranostic NPs, and their potential for clinical advances are also discussed...
  48. ncbi Quantum dots hold promise for early cancer imaging and detection
    Pericles Pericleous
    First Department of Surgery, Tzaneion General Hospital, Piraeus, Greece
    Int J Cancer 131:519-28. 2012
    ..In this review, we aim to describe the current utilisation of QDs as well as their future prospective to decipher and confront cancer...
  49. ncbi Luminescent quantum dots as platforms for probing in vitro and in vivo biological processes
    Hedi Mattoussi
    Florida State University, Department of Chemistry and Biochemistry, Tallahassee, FL 32306, USA
    Adv Drug Deliv Rev 64:138-66. 2012
    ..We conclude by discussing issues of toxicity associated with the use of QDs in biology...
  50. ncbi Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer
    Dong Kee Yi
    Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi do 461 701, Korea
    Bioconjug Chem 21:2173-7. 2010
    ..The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy...
  51. ncbi Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
    Gooitzen M van Dam
    Department of Surgery, Division of Surgical Oncology, BioOptical Imaging Center, University of Groningen, Groningen, The Netherlands
    Nat Med 17:1315-9. 2011
    ....
  52. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
    ..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
  53. pmc Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 18:8220-8. 2010
    ..The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases...
  54. ncbi Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands
    A Becker
    , 14050 Berlin, Germany
    Nat Biotechnol 19:327-31. 2001
    ..This imaging approach, combining the specificity of ligand/receptor interaction with near-infrared fluorescence detection, may be applied in various other fields of cancer diagnosis...
  55. ncbi Theranostics: combining imaging and therapy
    Sneha S Kelkar
    Department of Chemistry and Macromolecular and Interfaces Institute Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States
    Bioconjug Chem 22:1879-903. 2011
    ....
  56. ncbi Differentiation of normal skin and melanoma using high resolution hyperspectral imaging
    David T Dicker
    Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Biol Ther 5:1033-8. 2006
    ..This would assist multiple laboratories to participate in the input and retrieval of target spectral information...
  57. ncbi Use of new imaging techniques to predict tumour response to therapy
    Vanessa N Harry
    Department of Gynaecological Oncology, St Bartholomew s Hospital, London, UK
    Lancet Oncol 11:92-102. 2010
    ....
  58. pmc RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline
    Els L van Persijn van Meerten
    Department of Radiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Radiol 20:1456-67. 2010
    ..Alternative response criteria in patients with hepatocellular carcinoma and gastrointestinal stromal tumours are discussed...
  59. ncbi Advances in imaging secondary ion mass spectrometry for biological samples
    Steven G Boxer
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Annu Rev Biophys 38:53-74. 2009
    ..Recent applications of imaging mass spectrometry to cell biology, microbial communities, and biosynthetic pathways are summarized briefly, and studies of biological membrane organization are described in greater depth...
  60. ncbi Mullerian duct anomalies: imaging and clinical issues
    Robert N Troiano
    Department of Radiology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Radiology 233:19-34. 2004
    ..Laparoscopy and hysteroscopy are reserved for women in whom interventional therapy is likely to be undertaken...
  61. ncbi Non-invasive imaging of GFAP expression after neuronal damage in mice
    Lingyun Zhu
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    Neurosci Lett 367:210-2. 2004
    ....
  62. ncbi Clinical imaging of the high-risk or vulnerable atherosclerotic plaque
    Z A Fayad
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 89:305-16. 2001
    ....
  63. ncbi Retinal imaging and image analysis
    Michael D Abramoff
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52242, USA
    IEEE Rev Biomed Eng 3:169-208. 2010
    ..Throughout the paper, aspects of image acquisition, image analysis, and clinical relevance are treated together considering their mutually interlinked relationships...
  64. pmc Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice
    Scott J Goldman
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
    PLoS ONE 6:e18269. 2011
    ..Since solid tumors often contain hypoxic regions, we performed proof-of-principle experiments testing whether this transgenic mouse model may be used as a universal platform for non-invasive imaging analysis of spontaneous solid tumors...
  65. ncbi From proteomics to prescription-the search for COPD biomarkers
    Benjamin L Nicholas
    Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    COPD 6:298-303. 2009
    ..Cutting edge technology used for biomarker discovery, quantitation in biofluids and imaging biomarkers in whole body systems is reviewed...
  66. ncbi Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
    Xingyong Wu
    Quantum Dot Corporation, 26118 Research Rd, Hayward, CA 94545, USA
    Nat Biotechnol 21:41-6. 2003
    ..The results indicate that QD-based probes can be very effective in cellular imaging and offer substantial advantages over organic dyes in multiplex target detection...
  67. ncbi Qualification of imaging biomarkers for oncology drug development
    John C Waterton
    AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Eur J Cancer 48:409-15. 2012
    ....
  68. ncbi New approaches for imaging tumour responses to treatment
    Kevin Brindle
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK
    Nat Rev Cancer 8:94-107. 2008
    ..These can be used in clinical trials of new drugs to give an early indication of drug efficacy, and subsequently in the clinic to select the most effective therapy at an early stage of treatment...
  69. ncbi In vivo multiphoton microscopy of deep brain tissue
    Michael J Levene
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    J Neurophysiol 91:1908-12. 2004
    ..Microangiographies from deep capillaries and blood vessels containing fluorescein-dextran and quantum dot-labeled serum in wild-type mouse brain are also demonstrated...
  70. ncbi New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales
    S L Wearne
    Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neuroscience 136:661-80. 2005
    ....
  71. pmc Non-invasive imaging of cardiac activation and recovery
    Peter M van Dam
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands
    Ann Biomed Eng 37:1739-56. 2009
    ..The quality of the results and the required computation time permit the application of this inverse procedure in a clinical setting...
  72. ncbi Nanomaterial standards for efficacy and toxicity assessment
    Pavan P Adiseshaiah
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:99-112. 2010
    ..Finally, we show how knowledge of these properties (both of the nanoparticle and the cancer/tumor under study) can be used to design meaningful in vivo tests to evaluate nanoparticle efficacy...
  73. ncbi The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging
    Zhanwen Xing
    Nanobiotechnology Division, State Key Laboratory of Urban Water Resources and Environment, School of Sciences, Harbin Institute of Technology, Harbin, People s Republic of China
    Nanotechnology 21:145607. 2010
    ..Given the broad spectrum of potential clinical applications, the nano-sized contrast agent may provide a versatile adjunct for ultrasonic imaging enhancement and/or treatment of tumors...
  74. ncbi Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
    ..The importance of angiogenesis in cancer, chronic inflammatory diseases, age-related macular degeneration and reversal of ischemic heart and limb disease provides incentive for meeting these challenges...
  75. ncbi GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo
    Kenneth N Barton
    Department of Radiation Oncology, Detroit, Michigan 48202, USA
    Mol Ther 8:508-18. 2003
    ..Implementation of the GENIS (gene expression of Na/I symporter) technology in the clinic will facilitate optimization of future human gene therapy trials...
  76. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...
  77. ncbi Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    James L Tatum
    National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
    Int J Radiat Biol 82:699-757. 2006
    ....
  78. ncbi Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging
    Jeff S Xu
    Department of Biomedical Engineering, The Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA
    Biomaterials 31:1716-22. 2010
    ..Our research demonstrated the technical feasibility of using the dual-mode NB contrast agent for cancer targeting and simultaneous fluorescence/US imaging...
  79. pmc Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy
    Yun Sheng Chen
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 18:8867-78. 2010
    ....
  80. pmc New technologies for human cancer imaging
    John V Frangioni
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rm SL B05, Boston, MA 02215, USA
    J Clin Oncol 26:4012-21. 2008
    ..This review explores these emerging technologies and considers their potential impact on clinical care. Finally, those cancers that are currently difficult to image and quantify, such as ovarian cancer and acute leukemia, are discussed...
  81. ncbi Tumor detection using folate receptor-targeted imaging agents
    Emanuela I Sega
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Cancer Metastasis Rev 27:655-64. 2008
    ....
  82. ncbi Protease sensors for bioimaging
    Martin Funovics
    Center for Molecular Imaging Research, Harvard Medical School, Rm 5406, 149 13th St, Charlestown, MA 02129, USA
    Anal Bioanal Chem 377:956-63. 2003
    ..These agents are designed to be biocompatible, highly activatible, and able to produce bright NIRF following protease cleavage...
  83. pmc Viral nanoparticles as tools for intravital vascular imaging
    John D Lewis
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:354-60. 2006
    ....
  84. pmc Imagable 4T1 model for the study of late stage breast cancer
    Kai Tao
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    BMC Cancer 8:228. 2008
    ..New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported...
  85. pmc Noninvasive biophotonic imaging for monitoring of catheter-associated urinary tract infections and therapy in mice
    Jagath L Kadurugamuwa
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, California 94501, USA
    Infect Immun 73:3878-87. 2005
    ....
  86. ncbi Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Angiogenesis 12:17-24. 2009
    ..Furthermore, the current technology might be developed for molecular imaging of other pathophysiological processes...
  87. ncbi Fluorescent peptide probes for in vivo diagnostic imaging
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Biopolymers 76:391-403. 2004
    ..Several of them have been tested in various in vitro and in vivo models, and the obtained imaging information has been applied to disease detection, medical diagnosis, and drug evaluations...
  88. pmc Effect of microbubble size on fundamental mode high frequency ultrasound imaging in mice
    Shashank Sirsi
    Department of Chemical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 36:935-48. 2010
    ..The results of this study show that microbubbles can be tailored for optimal contrast enhancement in fundamental mode imaging...
  89. ncbi Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents
    Qingbei Zhang
    Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, AMB N339, MC1089, Chicago, IL 60637, USA
    Mol Cancer Ther 10:1173-84. 2011
    ..The optical imaging technology described here is thus a powerful, noninvasive, time-course imaging tool of functional tumor vessel normalization and its therapeutic consequences...
  90. pmc Imaging retinal mosaics in the living eye
    E A Rossi
    Center for Visual Science, University of Rochester, Rochester, NY, USA
    Eye (Lond) 25:301-8. 2011
    ..Two-photon imaging combined with adaptive optics can evaluate photoreceptor function non-invasively in the living primate retina...
  91. ncbi Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
    ..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...
  92. pmc Imaging genomics
    Paul M Thompson
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
    Curr Opin Neurol 23:368-73. 2010
    ..Along with clinical diagnosis and cognitive testing, brain imaging offers highly reproducible measures that can be subjected to genetic analysis...
  93. pmc Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Pharmacol Sci 31:199-205. 2010
    ..Specifically, we discuss the use of nanoparticles for molecular imaging and advanced therapeutics, specially designed drug eluting stents and in vivo/ex vivo early detection techniques...
  94. ncbi Episodic autobiographical memories over the course of time: cognitive, neuropsychological and neuroimaging findings
    Pascale Piolino
    Universite Paris Descartes, Institut de Psychologie, Paris, France
    Neuropsychologia 47:2314-29. 2009
    ..Our findings highlight the critical role of frontotemporal areas in constructive autobiographical memory processes, and especially hippocampus, in re-experiencing episodic details from the recent or more distant past...
  95. ncbi Imaging matrix metalloproteinases in cancer
    Randy L Scherer
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Metastasis Rev 27:679-90. 2008
    ..This review draws attention to a variety of strategies utilized to image MMP activity in vivo...
  96. ncbi Graves' orbitopathy: current imaging procedures
    Eberhard Kirsch
    Neuroradiology, Hirslanden Clinic Aarau, Aarau, Switzerland
    Swiss Med Wkly 139:618-23. 2009
    ..It is therefore the method of choice to plan CT-guided orbital decompression surgery in the inactive phase of GO...
  97. pmc Bioimage informatics: a new area of engineering biology
    Hanchuan Peng
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
    Bioinformatics 24:1827-36. 2008
    ....
  98. pmc Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer
    Chirayu Shah
    Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Clin Cancer Res 15:4712-21. 2009
    ..The correlation between tumor regression and molecular imaging of apoptosis, glucose metabolism, and cellular proliferation was evaluated longitudinally in responding and nonresponding tumor-bearing cohorts...
  99. ncbi Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy
    Jaeyun Kim
    National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151 744, South Korea
    Chem Soc Rev 38:372-90. 2009
    ..In this tutorial review, we will summarize the recent reports on the fabrication strategies of multifunctional nanoplatforms and their applications to targeted multimodal imaging and simultaneous diagnosis and therapy...
  100. ncbi In vivo optical imaging in arthritis--an enlightening future?
    Luke L Gompels
    Kennedy Institute of Rheumatology, Imperial College London, Faculty of Medicine, 65 Aspenlea Road, London W6 8LH, UK
    Rheumatology (Oxford) 49:1436-46. 2010
    ....
  101. ncbi Texture analysis of medical images
    G Castellano
    Neuroimage Laboratory, Faculty of Medical Sciences, State University of Campinas, Brazil
    Clin Radiol 59:1061-9. 2004
    ..In this article we clarify the principles of texture analysis and give examples of its applications, reviewing studies of the technique...

Research Grants74

  1. Multispectral diagnostic imaging of the iris
    ANA LUKIC; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): The objective of this project is to develop a prototype of a new diagnostic imaging device for use by eye care practitioners...
  2. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2007
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  3. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  4. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..We believe we will be able to establish OCT as a viable diagnostic imaging modality that can be used to monitor the neonatal airway and diagnose the early the onset SGS and other ICU ..
  5. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..for tPA treatment of ischemic stroke is time (3 hr post-ictus and CT exam negative for bleeding, as no diagnostic imaging indicators are available for excluding high-risk stroke patients...
  6. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..These peptides can be used for cell specific diagnostic imaging using molecular nanoplatforms with phage-nanogold or nano-gold peptide devices...
  7. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..Remarkably few studies have compared the effectiveness of expensive imaging technologies. Studies comparing diagnostic imaging tests must include not only an assessment of diagnostic accuracy, but also a range of outcomes including ..
  8. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ....
  9. Multifunctional nanoformulations for diagnostic imaging of atherosclerosis
    Alexander B Sigalov; Fiscal Year: 2012
    ....
  10. Clinical Decision Support for Mild Traumatic Brain Injury
    EDWARD ROBERT MELNICK; Fiscal Year: 2013
    ..The ED is the ideal setting to study overuse of diagnostic imaging as imaging rates of injured patients have tripled over ten years without a measurable improvement in patient ..
  11. MRI Imaging Biomarkers of ARPKD Kidney and Liver Disease
    Christopher A Flask; Fiscal Year: 2013
    ..And, unlike ADPKD, conventional diagnostic imaging techniques are also limited as kidney size may also be stable over time...
  12. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..This Primary Care Imaging system addresses this critical need, and for the first time, brings advanced diagnostic imaging technology to the primary care office.
  13. Novel High Affinity VEGF Analogs For Targeted Imaging of Thyroid Cancer
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..amp;co-developed Genzyme's recombinant human TSH (Thyrogen), currently approved for enhancing diagnostic imaging with radioiodine and for stimulation of the thyroid cancer serum marker, thyroglobulin (TG)...
  14. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..are of an important and under-investigated topic focusing on the comparative effectiveness of noninvasive diagnostic imaging techniques, serum-based assays, and liver biopsy for the accurate detection of hepatic fibrosis among human ..
  15. [F18]FMAU in Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Our project will form the solid foundation that is needed for future diagnostic imaging clinical trials of F-18 FMAU in men with prostate cancer, specifically in the large group of men who present ..
  16. Dual-Energy Cone-Beam Tomographic Imaging and Analysis for Rheumatoid Arthritis
    Jeffrey H Siewerdsen; Fiscal Year: 2013
    ..Despite the strides in diagnostic imaging capabilities, conventional approaches in MRI, ultrasound, radiography, and CT face a variety of limitations ..
  17. Phenotyping pain in a mouse model of pancreatic cancer
    Brian M Davis; Fiscal Year: 2012
    ..Despite advances in diagnostic imaging and surgical techniques, mortality still approaches incidence as non-specific and often late symptoms ..
  18. Detection of Glaucoma Progression with Macular OCT Imaging
    Kouros Nouri-Mahdavi; Fiscal Year: 2013
    ..objectives during the award period are as follows: 1) To develop an individual research program in glaucoma diagnostic imaging;2) to successfully complete credited coursework in biomathematics, advanced biostatistics, computer vision (..
  19. Magnetomotive optical coherence tomography for molecular imaging of the eye
    Jianhua Wang; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Molecular in vivo imaging allows for diagnostic imaging, target screening, and therapeutic monitoring of disease on a molecular level, prior to evidence of ..
  20. Understanding the inflammatory processes of neurocysticercosis: a US-India partne
    HELENE CARABIN; Fiscal Year: 2013
    ..New methods for diagnosing patients with NCC are badly needed. The cost of diagnostic imaging is beyond the means of most patients, and 34% of NCC patients are missed by the gold standard for antibody ..
  21. Noninvasive Visualization and Analysis of Organ Systems using OCT and Digital Fun
    Steven J Pittler; Fiscal Year: 2010
    ..Relevance: OCT is an emerging diagnostic imaging method enabling in vivo cross-sectional tomography of internal microstructures in living biological systems...
  22. Diagnostic Cancer Imaging using NIR Fluorescent Agents and FDPM
    Eva Sevick Muraca; Fiscal Year: 2009
    ..In this competitive renewal we seek to translate fluorescence enhanced optical imaging for clinical cancer diagnostic imaging for sentinel lymph node mapping in patients...
  23. MAGNETIC RESONANCE ELASTOGRAPHY
    Richard L Ehman; Fiscal Year: 2013
    ..The goal of this research is to develop, validate, explore and identify high-impact applications of a new diagnostic imaging technology for quantitatively assessing the mechanical properties of tissues...
  24. Comparative effectiveness of breast imaging modalities: a natural experiment
    Garth H Rauscher; Fiscal Year: 2013
    ..The sample size for this proposed study would far exceed any prior study on the topic of screening and diagnostic imaging accuracy in breast cancer...
  25. Free-Breathing Perfusion MRI of the Abdomen with Predictive Motion Correction
    H Michael Gach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The incidence of renal diseases is growing as the population ages. Diagnostic imaging serves a key role in detecting and monitoring renal diseases including renal cell carcinoma (RCC)...
  26. Monodispersed Biocompatible Magnetic Nanoprobes for Improved Diagnostic Imaging
    KANNAN MANJAPRA KRISHNAN; Fiscal Year: 2011
    ..irrespective of the surrounding tissue, and can be simultaneously targeted to disease sites for early diagnostic imaging. Our goal is to use Magnetic Particle Imaging (MPI), a new medical imaging technology recently introduced by ..
  27. Predicting Brain Recovery after Acute Hemorrhage and Resuscitation
    John J A Marota; Fiscal Year: 2010
    ..A successful outcome from this study would demonstrate that acute diagnostic imaging could be used to identify and define the extent of reversible or irreversible ischemic changes in brain ..
  28. Improved scintillators for time-of-flight positron emission tomography
    STEPHEN E DERENZO; Fiscal Year: 2013
    ..Time-of-Flight Positron Emission Tomography Project Summary/Abstract We propose to significantly improve the diagnostic imaging capability of positron emission tomography by finding new scintillators with the gamma-ray stopping power of ..
  29. Development of Thermoacoustic Tomography Brain Imaging
    Mark A Anastasio; Fiscal Year: 2013
    ..is a rapidly emerging ultrasound-mediated hybrid imaging modality that promises to have a major impact on diagnostic imaging. TAT combines high ultrasonic resolution and strong microwave contrast in a single hybrid modality...
  30. Imaging lymph function in humans and in a murine model of lymphedema
    Eva M Sevick-Muraca; Fiscal Year: 2012
    ..Yet despite the importance of the lymphatics in these diseases, diagnostic imaging approaches to non-invasively monitor lymph function are non-existent...
  31. AD LENS PATHOLOGY: BIOCHEMISTRY & DIAGNOSTIC IMAGING
    Lee E Goldstein; Fiscal Year: 2010
    ..The resulting data may provide insights into fundamental mechanisms of AD-associated protein aeration and support development of novel AD diagnostic and monitoring technology. ..
  32. Sulfatase Activated Fluorescent Probes for In Vivo Diagnostic Imaging of Cancer
    KIMBERLY ELIZABETH BEATTY; Fiscal Year: 2010
    ..The described probes are activated by extracellular sulfatases to give a distinct fluorescent signal at cancer cells. The probes are designed to enable early and accurate cancer diagnosis. ..
  33. 3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer
    Alexander A Oraevsky; Fiscal Year: 2013
    ABSTRACT [unreadable]3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer[unreadable] The objective of this project is to develop a new advanced imaging system to allow visualization of small cancerous tumors ..
  34. QUANTIFYING KIDNEY INJURY AND INFLAMMATION WITH FLUORINE (19F) MRI
    Samuel A Wickline; Fiscal Year: 2013
    ..and molecularly targeted perfluorocarbon nanoparticles (PFC NPs) that could offer numerous advantages for diagnostic imaging and drug delivery to chronic and acute kidney diseases...
  35. High Deductible Insurance: Impact on Breast Cancer Care and Outcomes
    James F Wharam; Fiscal Year: 2013
    ..Patients being evaluated for breast cancer require a spectrum of advanced medical care including diagnostic imaging and biopsy procedures...
  36. Non-invasive imaging of Staphylococcus aureus foreign-body infections
    JAMES O apos CONNELL MCNAMARA; Fiscal Year: 2013
    ..This contribution is significant because it will provide an essential foundation for the translation of a diagnostic imaging approach for S...
  37. MRI probes for functional imaging of plasticity signals in the brain
    Alan Jasanoff; Fiscal Year: 2013
    ..Second, the reagents we create may eventually be useful as diagnostic imaging tools in clinical practice, once they have proven safe and effective for measuring neural signaling ..
  38. Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration
    Qifa Zhou; Fiscal Year: 2013
    ..Techniques currently used for diagnostic imaging of AMD include indocyanine green dye or fluorescein angiography, autofluorescence imaging and optical ..
  39. Development of an Intraoral Optical Probe for the Microscopic Evaluation of Denta
    ADAM MICHAEL ZYSK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diagnostic imaging in modern dental practice still relies mainly on visual inspection or x-ray radiography, a technology that remains largely unchanged since the late 1800s...
  40. Training in Radiation Oncology Translational Research
    Ross B Mikkelsen; Fiscal Year: 2011
    ..Training in radiological physics includes formal courses in dosimetry, diagnostic imaging and instrumentation, and mentored research in intensity modulated radiotherapy, brachytherapy and diagnostic ..
  41. BOLD MRI: Application to Intra-renal Oxygenation
    Pottumarthi V Prasad; Fiscal Year: 2012
    ..With the continuing rise in the number of diagnostic imaging procedures and because it is a hospital acquired syndrome, the need for prevention is most compelling...
  42. Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
    Mark D Does; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Current methods for diagnostic imaging of bone are incomplete and do not fully predict the increase in fracture risk with age or advancement of ..
  43. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2013
    ..These studies will lead to improved and effective molecular imaging radiotracers and companion therapeutics that can be translated and evaluated clinically in patients with these devastating diseases. ..
  44. Biomarkers of Mild and Moderate Traumatic Brain Injury
    Linda Papa; Fiscal Year: 2012
    ..of these patients in many ways, such as: 1) assessing risk for intracranial bleeding;2) determining need for diagnostic imaging;3) determining need for neurosurgical intervention;4) assessing need for admission;5) helping with return to ..
  45. Synthesis of Radiofluorinated PET Imaging Agents
    STEPHEN DIMAGNO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Noninvasive diagnostic imaging of tissues is essential for determining the identification and staging of diseases, and assessing the efficacy of treatment regimens...
  46. Quantum FX Micro-CT Scanner
    G Gary Sahagian; Fiscal Year: 2013
    ..Two diagnostic imaging radiologists with CT expertise will serve as consultants to support the instrument and its users...
  47. Trauma Molecular Pathogenesis and Regeneration Training Grant
    RAPHAEL CARL LEE; Fiscal Year: 2013
    ..nucleic acid repair, animal research methods, clinical research guidelines, as well as computational and diagnostic imaging of molecular function. The proposed training program meets these requirements...
  48. Breast Cancer Risk Stratification with Resonant Electrical Impedance Spectroscopy
    David Gur; Fiscal Year: 2010
    ..demonstrate feasibility for pre-screening women with the REIS device to determine who would benefit from a diagnostic imaging workup. This is not a breast cancer detection device but rather a risk stratification approach...
  49. Novel RF Coils and k-t Space Imaging for Neonatal Chest MRI within NICUs
    Yu Li; Fiscal Year: 2013
    ..of premature births, there is a strong/compelling need for the routine use of low-cost and high-performance diagnostic imaging systems in neonatal patients within the Neonatal Intensive Care Unit (NICU)...
  50. Opportunities in Hydrocephalus: Pathways to Better Outcomes
    Samuel R Browd; Fiscal Year: 2012
    ..neurotrauma, developmental disorders, neural tube defects, bioengineering, infectious disease, diagnostic imaging, and applied mathematics...
  51. Implementation and Evaluation of Imaging Decision Support Incorporating CER
    G Scott Gazelle; Fiscal Year: 2010
    ..However, these advances are not without costs: diagnostic imaging represents a large and growing portion of total health care spending in the U.S...
  52. PET Enabled Microspheres for Radioembolization of Liver Tumors
    YONGREN BENJAMIN PENG; Fiscal Year: 2012
    ..However, the clinical results vary vastly due to the lack of accurate diagnostic imaging for dose and treatment planning, and the lack of image guidance and dose conformation during the ..
  53. Safety in Childbirth;Estimating benefits of risk appropriate obstetrical care
    Kimberly D Gregory; Fiscal Year: 2013
    ..g. the availability of sub-specialists, specialty intensive care units, blood banking services, and diagnostic imaging equipment to optimize outcomes and limit maternal morbidity...
  54. Optical probe for microscopic cancer identification in minute structures
    Martin Feldman; Fiscal Year: 2010
    ..gastric, and vascular tissues, and are looking forward to clinical applications of the probe, including diagnostic imaging of pancreatic lesions...
  55. Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and C
    James McAllister; Fiscal Year: 2009
    ..neurotrauma, developmental disorders, neural tube defects, bioengineering, infectious disease, diagnostic imaging, and applied mathematics...
  56. Nanoscale Metal-organic Frameworks for Imaging and Therapy of Pancreatic Cancer
    Jen Jen Yeh; Fiscal Year: 2013
    ..established UNC investigators with complementary expertise will take the challenge of developing sensitive diagnostic imaging modalities and effective therapies using targeted nanoparticle technology based on nanoscale metal-organic ..
  57. Multifunctional Peptides for (MRI) Imaging
    DUANE CARL KRAEMER; Fiscal Year: 2011
    ..77754) for advanced, refractory solid tumors. It also has potential for improving diagnostic imaging in human and veterinary patients...
  58. Nanotechnology Platform for Pediatric Brain Cancer Imaging and Therapy
    Miqin Zhang; Fiscal Year: 2009
    ..of small animal coil design, pulse sequences, and signal quantification);and clinical and small animal diagnostic imaging interpretation (Raymond Sze (UW, CHRMC), Principal Investigator)...
  59. Independent Scientist: ARFI and RWI Ultrasound for Improved Atherosclerosis Imagi
    Caterina M Gallippi; Fiscal Year: 2013
    ..However, administration of proper treatment is limited by inadequacies in modern diagnostic imaging technologies...
  60. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    Despite significant improvements in diagnostic imaging and neurosurgical techniques, the current treatment modalities for high-grade gliomas are inadequate...
  61. iDecide: A Mobile Decision Support Tool Used for Adjuvant Therapy
    Emily Meyers; Fiscal Year: 2012
    ..g., critical components of medical history, pathology reports and diagnostic imaging records) to facilitate second opinions;and (4) provide video vignettes conveying breast cancer survivors&..
  62. Software for improved accuracy and rapid tracking of kinematics from dynamic Xray
    W Scott Selbie; Fiscal Year: 2013
    ..While advances in diagnostic imaging (including CT, MRI and ultrasound) have greatly improved our ability to detect structural changes in ..
  63. PATIENT MOTION DETECTION AND COMPENSATION IN SPECT
    Michael A King; Fiscal Year: 2013
    ..by applicant): Patient motion is an ever-present potential cause of artifacts that can limit the accuracy of diagnostic imaging. The problem is especially significant for imaging modalities such as SPECT and PET, which require the ..
  64. Prussian Blue Nanoparticles as Cellular T1 MRI Contrast Agents
    Songping D Huang; Fiscal Year: 2013
    ..r1 relaxivity in a novel class of particulate T1-weighted MRI CAs, and thus will have high potential to produce a major breakthrough in MRI diagnostic imaging and may even completely change the landscape in this area of research.
  65. Research Training in Anesthesia
    Laura E Niklason; Fiscal Year: 2013
    ..include investigators from Anesthesia, as well as the Bioengineering Department and outstanding groups in Diagnostic Imaging. The fourth track, Clinical Research, will also leverage training resources within the Department, as well ..
  66. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2006
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  67. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    Bruce Weintraub; Fiscal Year: 2007
    ..both co-inventor and co-developer with Genzyme of wild type recombinant human TSH, currently approved for diagnostic imaging of thyroid cancer, now proposes to develop novel 123I or 125I-labeled high affinity TSH analogs for imaging ..
  68. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2010
    The use of diagnostic imaging has increased dramatically over the last 10 years. Concurrently, spectacular advances in imaging technology have allowed the detection of increasingly smaller anatomic lesions...
  69. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    ..The mainstay of diagnostic imaging in dental practices today is dental radiography (x-ray), which was first used in dentistry in 1885...
  70. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2005
    ..He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality...
  71. DNA-modulated release of drug from melanoma targeting NP
    Kit Lam; Fiscal Year: 2009
    ..In this R21 application we shall develop this novel nanotherapeutic approach in a melanoma xenograft model. ..
  72. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    b>Diagnostic imaging requires the sufficient intensity of a corresponding signal from an area of interest in order to obtain diagnostically significant images...
  73. Development of Superagonist Analogs of Recombinant Human TSH for Imaging and Ther
    Bruce Weintraub; Fiscal Year: 2009
    ..generation superactive analog of rh TSH for the 15-20% of poorly responsive thyroid cancer patients in diagnostic imaging as well as for the majority of such patients for radioiodine therapy...
  74. Radiation Exposure from Medical Imaging: are Doses in the Carcinogenic Range?
    Rebecca Smith Bindman; Fiscal Year: 2009
    ..Using this large, population-based database, we will describe patterns of diagnostic imaging over time, estimate temporal trends in radiation doses associated with imaging, and determine factors ..