diagnostic imaging

Summary

Summary: Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.

Top Publications

  1. pmc Imaging in the era of molecular oncology
    Ralph Weissleder
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA
    Nature 452:580-9. 2008
  2. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
  3. ncbi Luminescent quantum dots for multiplexed biological detection and imaging
    Warren C W Chan
    Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA
    Curr Opin Biotechnol 13:40-6. 2002
  4. pmc Far-red fluorescent tags for protein imaging in living tissues
    Dmitry Shcherbo
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Miklukho Maklaya 16 10, Moscow, Russia
    Biochem J 418:567-74. 2009
  5. pmc Non-invasive detection of a small number of bioluminescent cancer cells in vivo
    Jae Beom Kim
    Caliper Life Sciences Inc, Alameda, California, United States of America
    PLoS ONE 5:e9364. 2010
  6. ncbi Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models
    Tamara Troy
    Xenogen Corporation, USA
    Mol Imaging 3:9-23. 2004
  7. pmc Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
  8. pmc Development and applications of photo-triggered theranostic agents
    Prakash Rai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, United States
    Adv Drug Deliv Rev 62:1094-124. 2010
  9. ncbi RECIST revisited: a review of validation studies on tumour assessment
    P Therasse
    EORTC Data Center, avenue E Mounier, 83 Box 11, 1200 Brussels, Belgium
    Eur J Cancer 42:1031-9. 2006
  10. ncbi The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data
    Daniel S Marcus
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Neuroinformatics 5:11-34. 2007

Detail Information

Publications346 found, 100 shown here

  1. pmc Imaging in the era of molecular oncology
    Ralph Weissleder
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA
    Nature 452:580-9. 2008
    ....
  2. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
    ..In vivo imaging showed a 12-fold increase in NIRF signal, allowing the detection of tumors with submillimeter-sized diameters. This strategy can be used to detect such early stage tumors in vivo and to probe for specific enzyme activity...
  3. ncbi Luminescent quantum dots for multiplexed biological detection and imaging
    Warren C W Chan
    Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA
    Curr Opin Biotechnol 13:40-6. 2002
    ..These novel optical properties render quantum dots ideal fluorophores for ultrasensitive, multicolor, and multiplexing applications in molecular biotechnology and bioengineering...
  4. pmc Far-red fluorescent tags for protein imaging in living tissues
    Dmitry Shcherbo
    Shemiakin Ovchinnikov Institute of Bioorganic Chemistry, Miklukho Maklaya 16 10, Moscow, Russia
    Biochem J 418:567-74. 2009
    ..Together, monomeric mKate2 and pseudo-monomeric tdKatushka2 represent the next generation of extra-bright far-red fluorescent probes offering novel possibilities for fluorescent imaging of proteins in living cells and animals...
  5. pmc Non-invasive detection of a small number of bioluminescent cancer cells in vivo
    Jae Beom Kim
    Caliper Life Sciences Inc, Alameda, California, United States of America
    PLoS ONE 5:e9364. 2010
    ..Significantly higher luciferase activity in these cells allowed us to detect micrometastases in both, syngeneic Balb/c and nu/nu mice...
  6. ncbi Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models
    Tamara Troy
    Xenogen Corporation, USA
    Mol Imaging 3:9-23. 2004
    ..The use of blue-shifted excitation filters is explored as a method to subtract out tissue autofluorescence and improve the sensitivity of fluorescent imaging...
  7. pmc Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
    ..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology...
  8. pmc Development and applications of photo-triggered theranostic agents
    Prakash Rai
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, United States
    Adv Drug Deliv Rev 62:1094-124. 2010
    ..Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases...
  9. ncbi RECIST revisited: a review of validation studies on tumour assessment
    P Therasse
    EORTC Data Center, avenue E Mounier, 83 Box 11, 1200 Brussels, Belgium
    Eur J Cancer 42:1031-9. 2006
    ..The findings of this review, together with experience acquired thus far and the results of some ongoing research projects, have paved the way for RECIST 2.0 to be hopefully announced later this year...
  10. ncbi The Extensible Neuroimaging Archive Toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data
    Daniel S Marcus
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    Neuroinformatics 5:11-34. 2007
    ..By managing data with XNAT, laboratories are prepared to better maintain the long-term integrity of their data, to explore emergent relations across data types, and to share their data with the broader neuroimaging community...
  11. ncbi Self-illuminating quantum dot conjugates for in vivo imaging
    Min Kyung So
    Molecular Imaging Program, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, California 94305 5484, USA
    Nat Biotechnol 24:339-43. 2006
    ..Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10(3) for 5 pmol of conjugate...
  12. doi Magnetic resonance electrical impedance tomography (MREIT) for high-resolution conductivity imaging
    Eung Je Woo
    Department of Biomedical Engineering, Kyung Hee University, Korea
    Physiol Meas 29:R1-26. 2008
    ..Suggestions for future research directions, possible applications in biomedicine, biology, chemistry and material science are discussed...
  13. pmc In vitro and in vivo two-photon luminescence imaging of single gold nanorods
    Haifeng Wang
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:15752-6. 2005
    ..The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels...
  14. pmc Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging
    Ivo H J Ploemen
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    PLoS ONE 4:e7881. 2009
    ....
  15. pmc Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009
    ..Because their wavelengths penetrate tissue well, IFPs are suitable for whole-body imaging. The IFPs developed here provide a scaffold for further engineering...
  16. pmc Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging
    Praveen D Chowdary
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 70:9562-9. 2010
    ..By optimizing optical sources and beam delivery, this technique can potentially enable real-time point-of-care optical molecular imaging and diagnosis...
  17. doi Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer
    Dong Kee Yi
    Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi do 461 701, Korea
    Bioconjug Chem 21:2173-7. 2010
    ..The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy...
  18. doi Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives
    Megan A Hahn
    Particle Engineering Research Center, University of Florida, 205 Particle Science and Technology Building, P O Box 116135, Gainesville, FL 32611, USA
    Anal Bioanal Chem 399:3-27. 2011
    ..Emerging technologies, for example multifunctional and theranostic NPs, and their potential for clinical advances are also discussed...
  19. pmc Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle
    Nobuyuki Kosaka
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 1088, USA
    Contrast Media Mol Imaging 6:55-9. 2011
    ..These advantages of BRET-QDot allowed us to perform real-time, quantitative lymphatic imaging without image processing. BRET-Qdots have the potential to be a robust nano-material platform for developing optical molecular imaging probes...
  20. doi Luminescent quantum dots as platforms for probing in vitro and in vivo biological processes
    Hedi Mattoussi
    Florida State University, Department of Chemistry and Biochemistry, Tallahassee, FL 32306, USA
    Adv Drug Deliv Rev 64:138-66. 2012
    ..We conclude by discussing issues of toxicity associated with the use of QDs in biology...
  21. ncbi Optical imaging: current applications and future directions
    Gary D Luker
    University of Michigan, Ann Arbor, Michigan, USA
    J Nucl Med 49:1-4. 2008
    ..In this review, we summarize recent advances in optical techniques for molecular imaging and the potential impact for clinical medicine...
  22. doi Qualification of imaging biomarkers for oncology drug development
    John C Waterton
    AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Eur J Cancer 48:409-15. 2012
    ....
  23. doi Quantum dots hold promise for early cancer imaging and detection
    Pericles Pericleous
    First Department of Surgery, Tzaneion General Hospital, Piraeus, Greece
    Int J Cancer 131:519-28. 2012
    ..In this review, we aim to describe the current utilisation of QDs as well as their future prospective to decipher and confront cancer...
  24. doi Theranostics: combining imaging and therapy
    Sneha S Kelkar
    Department of Chemistry and Macromolecular and Interfaces Institute Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, United States
    Bioconjug Chem 22:1879-903. 2011
    ....
  25. pmc Photoacoustic imaging of mesenchymal stem cells in living mice via silica-coated gold nanorods
    Jesse V Jokerst
    Molecular Imaging Program at Stanford, Department of Radiology, 318 Campus Drive, Stanford University, Stanford, California 94305 5427, United States
    ACS Nano 6:5920-30. 2012
    ..This approach has significant advantages over traditional cell imaging techniques like positron emission tomography and magnetic resonance imaging including real time monitoring of stem cell therapy...
  26. doi Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
    Gooitzen M van Dam
    Department of Surgery, Division of Surgical Oncology, BioOptical Imaging Center, University of Groningen, Groningen, The Netherlands
    Nat Med 17:1315-9. 2011
    ....
  27. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
    ..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
  28. pmc Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 18:8220-8. 2010
    ..The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases...
  29. doi Nanomaterial standards for efficacy and toxicity assessment
    Pavan P Adiseshaiah
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:99-112. 2010
    ..Finally, we show how knowledge of these properties (both of the nanoparticle and the cancer/tumor under study) can be used to design meaningful in vivo tests to evaluate nanoparticle efficacy...
  30. ncbi New techniques for imaging, digitization and analysis of three-dimensional neural morphology on multiple scales
    S L Wearne
    Computational Neurobiology and Imaging Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Neuroscience 136:661-80. 2005
    ....
  31. doi The fabrication of novel nanobubble ultrasound contrast agent for potential tumor imaging
    Zhanwen Xing
    Nanobiotechnology Division, State Key Laboratory of Urban Water Resources and Environment, School of Sciences, Harbin Institute of Technology, Harbin, People s Republic of China
    Nanotechnology 21:145607. 2010
    ..Given the broad spectrum of potential clinical applications, the nano-sized contrast agent may provide a versatile adjunct for ultrasonic imaging enhancement and/or treatment of tumors...
  32. ncbi GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo
    Kenneth N Barton
    Department of Radiation Oncology, Detroit, Michigan 48202, USA
    Mol Ther 8:508-18. 2003
    ..Implementation of the GENIS (gene expression of Na/I symporter) technology in the clinic will facilitate optimization of future human gene therapy trials...
  33. pmc Non-invasive imaging of cardiac activation and recovery
    Peter M van Dam
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands
    Ann Biomed Eng 37:1739-56. 2009
    ..The quality of the results and the required computation time permit the application of this inverse procedure in a clinical setting...
  34. ncbi Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
    ..The importance of angiogenesis in cancer, chronic inflammatory diseases, age-related macular degeneration and reversal of ischemic heart and limb disease provides incentive for meeting these challenges...
  35. ncbi Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    James L Tatum
    National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
    Int J Radiat Biol 82:699-757. 2006
    ....
  36. pmc Enhanced thermal stability of silica-coated gold nanorods for photoacoustic imaging and image-guided therapy
    Yun Sheng Chen
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 18:8867-78. 2010
    ....
  37. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...
  38. doi Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging
    Jeff S Xu
    Department of Biomedical Engineering, The Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA
    Biomaterials 31:1716-22. 2010
    ..Our research demonstrated the technical feasibility of using the dual-mode NB contrast agent for cancer targeting and simultaneous fluorescence/US imaging...
  39. pmc New technologies for human cancer imaging
    John V Frangioni
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rm SL B05, Boston, MA 02215, USA
    J Clin Oncol 26:4012-21. 2008
    ..This review explores these emerging technologies and considers their potential impact on clinical care. Finally, those cancers that are currently difficult to image and quantify, such as ovarian cancer and acute leukemia, are discussed...
  40. pmc A rapidly maturing far-red derivative of DsRed-Express2 for whole-cell labeling
    Rita L Strack
    Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Biochemistry 48:8279-81. 2009
    ..We show that E2-Crimson has unique applications for flow cytometry and stimulated emission depletion (STED) microscopy...
  41. doi Tumor detection using folate receptor-targeted imaging agents
    Emanuela I Sega
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Cancer Metastasis Rev 27:655-64. 2008
    ....
  42. ncbi Protease sensors for bioimaging
    Martin Funovics
    Center for Molecular Imaging Research, Harvard Medical School, Rm 5406, 149 13th St, Charlestown, MA 02129, USA
    Anal Bioanal Chem 377:956-63. 2003
    ..These agents are designed to be biocompatible, highly activatible, and able to produce bright NIRF following protease cleavage...
  43. pmc Noninvasive biophotonic imaging for monitoring of catheter-associated urinary tract infections and therapy in mice
    Jagath L Kadurugamuwa
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, California 94501, USA
    Infect Immun 73:3878-87. 2005
    ....
  44. pmc Imagable 4T1 model for the study of late stage breast cancer
    Kai Tao
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    BMC Cancer 8:228. 2008
    ..New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported...
  45. pmc Viral nanoparticles as tools for intravital vascular imaging
    John D Lewis
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:354-60. 2006
    ....
  46. ncbi Fluorescent peptide probes for in vivo diagnostic imaging
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Biopolymers 76:391-403. 2004
    ..Several of them have been tested in various in vitro and in vivo models, and the obtained imaging information has been applied to disease detection, medical diagnosis, and drug evaluations...
  47. ncbi Improving lesion-symptom mapping
    Chris Rorden
    Department of Communication Sciences and Disorders, University of South Carolina, SC 29208, USA
    J Cogn Neurosci 19:1081-8. 2007
    ..We also developed software to implement these tests (MRIcron), made freely available to the scientific community...
  48. ncbi Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Angiogenesis 12:17-24. 2009
    ..Furthermore, the current technology might be developed for molecular imaging of other pathophysiological processes...
  49. pmc Imaging biomarkers predict response to anti-HER2 (ErbB2) therapy in preclinical models of breast cancer
    Chirayu Shah
    Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Clin Cancer Res 15:4712-21. 2009
    ..The correlation between tumor regression and molecular imaging of apoptosis, glucose metabolism, and cellular proliferation was evaluated longitudinally in responding and nonresponding tumor-bearing cohorts...
  50. ncbi Graves' orbitopathy: current imaging procedures
    Eberhard Kirsch
    Neuroradiology, Hirslanden Clinic Aarau, Aarau, Switzerland
    Swiss Med Wkly 139:618-23. 2009
    ..It is therefore the method of choice to plan CT-guided orbital decompression surgery in the inactive phase of GO...
  51. pmc Bioimage informatics: a new area of engineering biology
    Hanchuan Peng
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
    Bioinformatics 24:1827-36. 2008
    ....
  52. ncbi Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon
    Jens Duebel
    Department of Biomedical Optics, Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 49:81-94. 2006
    ..Blockers of Cl(-) transporters reduced the somatodendritic [Cl(-)](i) gradient. Hence, our results support the idea that ON bipolar cells employ a somatodendritic [Cl(-)](i) gradient to invert GABAergic horizontal cell input...
  53. ncbi In-vivo high-resolution X-ray microtomography for liver and spleen tumor assessment in mice
    M Almajdub
    ANIMAGE, Rhône Alpes GENOPOLE, Universite de Lyon, Bât CERMEP 59, boulevard Pinel, 69677 Bron Cedex, France
    Contrast Media Mol Imaging 2:88-93. 2007
    ..3 mm in diameter. High-resolution X-ray micro-CT in living mice using DHOG contrast agent allowed visualization and volume quantification of normal spleen and of spleen tumor and its liver metastases...
  54. doi Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy
    Jaeyun Kim
    National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151 744, South Korea
    Chem Soc Rev 38:372-90. 2009
    ..In this tutorial review, we will summarize the recent reports on the fabrication strategies of multifunctional nanoplatforms and their applications to targeted multimodal imaging and simultaneous diagnosis and therapy...
  55. ncbi Optical imaging in drug discovery and diagnostic applications
    K Licha
    Schering AG, Research Laboratories, Mullerstrasse 178, D 13342 Berlin, Germany
    Adv Drug Deliv Rev 57:1087-108. 2005
    ....
  56. ncbi Localized recrudescence of Toxoplasma infections in the central nervous system of immunocompromised mice assessed by in vivo bioluminescence imaging
    Isabel Dellacasa-Lindberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Microbes Infect 9:1291-8. 2007
    ..Collectively, the findings suggest that the localization of reactivation foci in the CNS, in conjunction with immune responses, influences the outcome of acute reactivated Toxoplasma encephalitis...
  57. ncbi Texture analysis of medical images
    G Castellano
    Neuroimage Laboratory, Faculty of Medical Sciences, State University of Campinas, Brazil
    Clin Radiol 59:1061-9. 2004
    ..In this article we clarify the principles of texture analysis and give examples of its applications, reviewing studies of the technique...
  58. doi In vivo optical imaging in arthritis--an enlightening future?
    Luke L Gompels
    Kennedy Institute of Rheumatology, Imperial College London, Faculty of Medicine, 65 Aspenlea Road, London W6 8LH, UK
    Rheumatology (Oxford) 49:1436-46. 2010
    ....
  59. doi Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?
    Susanne Bonekamp
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Hepatol 50:17-35. 2009
    ..However, to date only magnetic resonance elastography has been able to stage fibrosis or diagnose mild disease. Utrasonographic elastography and magnetic resonance diffusion weighted appear next most promising...
  60. ncbi Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes
    Galia Blum
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, California 94305, USA
    Nat Chem Biol 3:668-77. 2007
    ..Thus, NIRF-ABPs are (i) potentially valuable new imaging agents for disease diagnosis and (ii) powerful tools for preclinical and clinical testing of small-molecule therapeutic agents in vivo...
  61. doi Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging
    Ronald N Germain
    Laboratory of Immunology, Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 221:163-81. 2008
    ..We also describe how the methods we have developed for imaging within lymphoid sites are being applied to other tissues and organs, revealing dynamic details of host-pathogen interactions previously inaccessible to direct observation...
  62. ncbi New concepts in synaptic biology derived from single-molecule imaging
    Antoine Triller
    INSERM UR497, Ecole Normale Superieure, Biologie Cellulaire de la Synapse N and P, 46 rue d Ulm, 75005 Paris, France
    Neuron 59:359-74. 2008
    ..In this primer, we will review the different approaches used to track single molecules in live neurons, compare them to bulk measurements, and discuss the different concepts that have emerged from their application to synaptic biology...
  63. doi Imaging of integrin alphavbeta3 expression
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Cancer Metastasis Rev 27:631-44. 2008
    ..The various advantages and disadvantages of several imaging techniques will be discussed in this article...
  64. doi Automated image analysis in histopathology: a valuable tool in medical diagnostics
    Laoighse Mulrane
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Expert Rev Mol Diagn 8:707-25. 2008
    ..Reinforced by the phenomenal growth of the virtual pathology field, it is envisioned that the market for automated image analysis tools will greatly expand over the next 10 years...
  65. ncbi Beyond phrenology: what can neuroimaging tell us about distributed circuitry?
    Karl Friston
    The Wellcome Department of Cognitive Neurology, University College London, Queen Square, United Kingdom
    Annu Rev Neurosci 25:221-50. 2002
    ..The conclusion, from these sorts of neuroimaging studies, points to the prevalence of top-down influences and the plausibility of generative models of sensory brain function...
  66. ncbi Quantification of histochemical staining by color deconvolution
    A C Ruifrok
    Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Anal Quant Cytol Histol 23:291-9. 2001
    ....
  67. ncbi Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice
    Zhen Cheng
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, California 94305 5344, USA
    Bioconjug Chem 16:1433-41. 2005
    ..The multmerization of RGD peptide results in moderate improvement of imaging characteristics of the tetramer, compared to that of the monomer and dimeric counterparts...
  68. ncbi Diagnostic imaging practice guidelines for musculoskeletal complaints in adults--an evidence-based approach: introduction
    André E Bussières
    Chiropractic Department, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    J Manipulative Physiol Ther 30:617-83. 2007
    ..The purpose of this project was to develop evidence-based diagnostic imaging practice guidelines for musculoskeletal complaints for use by doctors of chiropractic and other primary ..
  69. pmc Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression
    Joeri Kuil
    Division of Diagnostic Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands
    Mol Pharm 8:2444-53. 2011
    ..Thus, multimerization of the cyclic Ac-TZ14011 peptide reduces the negative influence of the multimodal label on the receptor affinity and the biodistribution...
  70. pmc In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography
    Viviane Mumprecht
    Institute of Pharmaceutical Sciences and Philochem AG, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Cancer Res 70:8842-51. 2010
    ..Immuno-PET with lymphatic-specific antibodies may open up new avenues for the early detection of metastasis, and the images obtained might be used as biomarkers for the progression of diseases associated with lymphangiogenesis...
  71. doi The role of atherosclerosis imaging in redefining normal and abnormal cholesterol values, and risk reduction in primary prevention statin trials
    Harvey S Hecht
    Lenox Hill Heart and Vascular Institute, 130 E 77th St, New York, NY 10021, USA
    Curr Atheroscler Rep 13:422-30. 2011
    ....
  72. doi Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging
    Keiichi Magota
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Nucl Med Mol Imaging 38:742-52. 2011
    ..We investigated the performance of the Inveon small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and PET components...
  73. ncbi Semiconductor quantum dots as contrast agents for whole animal imaging
    Wen Jiang
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, 407, Toronto, Ontario M5S 3G9, Canada
    Trends Biotechnol 22:607-9. 2004
    ..The possible future use of QDs for clinical applications is expected to have a significant impact, however many challenges in this field have yet to be overcome...
  74. pmc In vivo imaging in cancer
    John Condeelis
    Anatomy and Structural Biology, Gruss Lipper Biophotonics Center, Program in Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Cold Spring Harb Perspect Biol 2:a003848. 2010
    ..Examples of new insights derived from the different scales of imaging and relevant probes are discussed in the context of cancer progression and metastasis...
  75. doi An efficient method for nonnegatively constrained Total Variation-based denoising of medical images corrupted by Poisson noise
    G Landi
    Department of Mathemtics, Uniersity of Bologna, Italy
    Comput Med Imaging Graph 36:38-46. 2012
    ..The numerical results on simulated and real medical images prove the effectiveness of the method, both for the accuracy and the computational cost...
  76. ncbi Mass spectrometry imaging for drug distribution studies
    Brendan Prideaux
    Novartis Institutes for BioMedical Research, Basel, Switzerland Public Health Research Institute, Newark, NJ 07103, USA
    J Proteomics 75:4999-5013. 2012
    ..In this article we review the different MSI technologies that have been applied to the imaging of pharmaceuticals. Recent technical advances, applications and current analytical limitations are discussed...
  77. doi Photothermal cancer therapy and imaging based on gold nanorods
    Won Il Choi
    School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 261 Cheomdan gwagiro, Buk Gu, Gwangju 500 712, Korea
    Ann Biomed Eng 40:534-46. 2012
    ..In this review, we discuss the recent progress of in vitro and in vivo explorations of the diagnostic and therapeutic applications of GNRs as a component of cancer therapy...
  78. ncbi imzML--a common data format for the flexible exchange and processing of mass spectrometry imaging data
    Thorsten Schramm
    Justus Liebig University, Giessen, Germany
    J Proteomics 75:5106-10. 2012
    ..All technical details necessary to implement imzML and additional background information is available at www.imzml.org...
  79. doi Polypyrrole nanoparticles: a potential optical coherence tomography contrast agent for cancer imaging
    Kin Man Au
    Department of Chemistry, The University of Sheffield, Brook Hill, Yorkshire, UK
    Adv Mater 23:5792-5. 2011
    ..Quantitative optical coherence tomography studies on tissue phantoms and Mie scattering calculations indicate their potential application for early-stage cancer diagnosis...
  80. pmc Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers
    Mary E Caldorera-Moore
    Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
    Acc Chem Res 44:1061-70. 2011
    ..This Account explores recent advances in the field of nanotheranostics and the various fundamental components of an effective theranostic carrier...
  81. doi Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
    Min Suk Shim
    Department of Chemical Engineering and Materials Science, University of California, Irvine, 92697, USA
    Adv Drug Deliv Rev 64:1046-59. 2012
    ....
  82. pmc FT-IR imaging of native and tissue-engineered bone and cartilage
    Adele Boskey
    Hospital for Special Surgery and Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Biomaterials 28:2465-78. 2007
    ....
  83. ncbi Use of new imaging techniques to predict tumour response to therapy
    Vanessa N Harry
    Department of Gynaecological Oncology, St Bartholomew s Hospital, London, UK
    Lancet Oncol 11:92-102. 2010
    ....
  84. doi Imaging evaluation in the patient with renal stone disease
    Jessica A Mandeville
    Department of Urology, IU Health Physicians Indiana University School of Medicine, Indianapolis, IN, USA
    Semin Nephrol 31:254-8. 2011
    ..This article reviews the indications, advantages, and disadvantages of each study in the evaluation of patients with known or suspected stone disease...
  85. ncbi In vivo small animal imaging: current status and future prospects
    George C Kagadis
    Department of Medical Physics, School of Medicine, University of Patras, P O BOX 132 73, GR 265 04 Rion, Greece
    Med Phys 37:6421-42. 2010
    ..Proposed hybrid approaches for diagnosis and targeted site-specific therapy are highlighted to offer an intriguing glimpse of the future...
  86. ncbi Deformable models in medical image analysis: a survey
    T McInerney
    Department of Computer Science, University of Toronto, ON, Canada
    Med Image Anal 1:91-108. 1996
    ....
  87. doi Diagnostic imaging for low back pain: advice for high-value health care from the American College of Physicians
    Roger Chou
    Oregon Health and Science University, Portland, OR, USA
    Ann Intern Med 154:181-9. 2011
    b>Diagnostic imaging is indicated for patients with low back pain only if they have severe progressive neurologic deficits or signs or symptoms that suggest a serious or specific underlying condition...
  88. pmc Cancer risk related to low-dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction
    Mark J Eisenberg
    Division of Cardiology, Jewish General Hospital, Montreal, Que
    CMAJ 183:430-6. 2011
    ..Patients exposed to low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction may be at increased risk of cancer...
  89. ncbi In vivo imaging of light-emitting probes
    B W Rice
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    J Biomed Opt 6:432-40. 2001
    ..Instrumentation for in vivo imaging developed at Xenogen is described and several examples of images of mice with bioluminescent cells are presented...
  90. doi Imaging ovarian cancer and peritoneal metastases--current and emerging techniques
    Stavroula Kyriazi
    Section of Magnetic Resonance, Cancer Research UK and EPSRC Cancer Imaging Center, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    Nat Rev Clin Oncol 7:381-93. 2010
    ..The combination of functional information with conventional anatomical visualization holds promise to accurately characterize peritoneal disease, and provides noninvasive biomarkers of therapeutic performance and patient prognosis...
  91. ncbi Whole-body imaging with fluorescent proteins
    Robert M Hoffman
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, California 92111, USA
    Nat Protoc 1:1429-38. 2006
    ..Fluorescent protein-based imaging technology can be used for whole-body imaging of fluorescent cells on essentially all organs. The timeline for these experiments varies from 2 days to 2 months...
  92. ncbi Use of non-invasive bioluminescent imaging to assess mycobacterial dissemination in mice, treatment with bactericidal drugs and protective immunity
    Frank Heuts
    Department of Microbiology, Karolinska Institute, Box 280, 17177 Stockholm, Sweden
    Microbes Infect 11:1114-21. 2009
    ....
  93. pmc Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models
    Joy L Kovar
    Molecular Biology, LI COR Biosciences, Lincoln, NE 68504, USA
    Anal Biochem 384:254-62. 2009
    ..In all cases, tumors were clearly imaged with good signal-to-noise characteristics. These data indicate that IRDye 800CW 2-DG is a broadly applicable optical imaging agent for in vivo imaging of neoplasms in mice...
  94. pmc Intraoperative near-infrared fluorescence imaging in perforator flap reconstruction: current research and early clinical experience
    Bernard T Lee
    Division of Plastic and Reconstructive Surgery, Boston, Massachusetts, USA
    J Reconstr Microsurg 26:59-65. 2010
    ..In this article, we review our preclinical and clinical data, as well as literature describing the use of similar NIR fluorescence imaging systems in plastic and reconstructive surgery...
  95. pmc Noninvasive imaging and radiovirotherapy of prostate cancer using an oncolytic measles virus expressing the sodium iodide symporter
    Pavlos Msaouel
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Ther 17:2041-8. 2009
    ..The NIS transgene allows viral localization and monitoring by noninvasive imaging which can facilitate dose optimization in a clinical setting...
  96. doi Multimodal imaging and treatment of bone metastasis
    Eric L Kaijzel
    Department of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Clin Exp Metastasis 26:371-9. 2009
    ..In this paper, we discuss the use of optical imaging strategies--either alone or in combination with CT--to study intrabone tumor growth, tumor progression and to monitor efficacy of therapeutic agents in metastatic bone disease...
  97. ncbi Introduction to the physics of molecular imaging with radioactive tracers in small animals
    Michael A King
    Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem Suppl 39:221-30. 2002
    ..Finally, positron emission tomography (PET) which relies on the simultaneous detection of the pair of gamma-rays formed when the positron annihilates is presented...
  98. ncbi The potential Salmonella aroA- vaccine strain is safe and effective in young BALB/c mice
    Stacy M Burns-Guydish
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Neonatology 91:114-20. 2007
    ..Due to the increased susceptibility of neonates to pathogens including those with mutations, the use of live vaccine strategies in the human population may present a potential risk to the young...
  99. doi Radiogenomics: creating a link between molecular diagnostics and diagnostic imaging
    Aaron M Rutman
    Department of Radiology, University of California San Diego Medical Center, San Diego, CA 92103, USA
    Eur J Radiol 70:232-41. 2009
    ..These findings underline a potential future role of both diagnostic and interventional radiologists in genetic assessment of cancer patients with radiographic imaging studies...
  100. doi Brain tumor imaging in clinical trials
    J W Henson
    Stephen E and Catherine Pappas Brain Tumor Imaging Research Program, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 29:419-24. 2008
    ....
  101. pmc A review of methods for quantitative evaluation of spinal curvature
    Tomaz Vrtovec
    Laboratory of Imaging Technologies, Faculty of Electrical Engineering, University of Ljubljana, Trzaska cesta 25, 1000, Ljubljana, Slovenia
    Eur Spine J 18:593-607. 2009
    ..Key evaluation issues and future considerations, supported by the results of the overview, are also discussed...

Research Grants76

  1. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert Knight; Fiscal Year: 2009
    ..for tPA treatment of ischemic stroke is time (3 hr post-ictus and CT exam negative for bleeding, as no diagnostic imaging indicators are available for excluding high-risk stroke patients...
  2. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..Remarkably few studies have compared the effectiveness of expensive imaging technologies. Studies comparing diagnostic imaging tests must include not only an assessment of diagnostic accuracy, but also a range of outcomes including ..
  3. CORE--RESEARCH ANIMAL SUPPORT FACILITY
    Kenneth Gray; Fiscal Year: 2003
    ..It also provides clinical, surgical, diagnostic imaging, and radiation therapy facilities and services as well as diagnostic and pathology laboratory facilities and ..
  4. Improving Outcomes in Hydrocephalus: Bridging the Gap between Basic Science and C
    James McAllister; Fiscal Year: 2009
    ..neurotrauma, developmental disorders, neural tube defects, bioengineering, infectious disease, diagnostic imaging, and applied mathematics...
  5. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..are of an important and under-investigated topic focusing on the comparative effectiveness of noninvasive diagnostic imaging techniques, serum-based assays, and liver biopsy for the accurate detection of hepatic fibrosis among human ..
  6. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant Talwalkar; Fiscal Year: 2009
    ..are of an important and under-investigated topic focusing on the comparative effectiveness of noninvasive diagnostic imaging techniques, serum-based assays, and liver biopsy for the accurate detection of hepatic fibrosis among human ..
  7. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..for tPA treatment of ischemic stroke is time (3 hr post-ictus and CT exam negative for bleeding, as no diagnostic imaging indicators are available for excluding high-risk stroke patients...
  8. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2006
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  9. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2003
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  10. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 1999
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  11. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2005
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  12. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2001
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  13. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2000
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  14. Understanding the inflammatory processes of neurocysticercosis: a US-India partne
    HELENE CARABIN; Fiscal Year: 2011
    ..New methods for diagnosing patients with NCC are badly needed. The cost of diagnostic imaging is beyond the means of most patients, and 34% of NCC patients are missed by the gold standard for antibody ..
  15. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin Tuder; Fiscal Year: 2009
    ..These peptides can be used for cell specific diagnostic imaging using molecular nanoplatforms with phage-nanogold or nano-gold peptide devices...
  16. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..These peptides can be used for cell specific diagnostic imaging using molecular nanoplatforms with phage-nanogold or nano-gold peptide devices...
  17. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    Bruce Weintraub; Fiscal Year: 2007
    ..both co-inventor and co-developer with Genzyme of wild type recombinant human TSH, currently approved for diagnostic imaging of thyroid cancer, now proposes to develop novel 123I or 125I-labeled high affinity TSH analogs for imaging ..
  18. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    Bruce Weintraub; Fiscal Year: 2006
    ..both co-inventor and co-developer with Genzyme of wild type recombinant human TSH, currently approved for diagnostic imaging of thyroid cancer, now proposes to develop novel 123I or 125I-labeled high affinity TSH analogs for imaging ..
  19. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2004
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  20. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2002
    ..for selective localization of estrogens, which if labeled with suitable radionuclides, could be used for diagnostic imaging or radiotherapy or breast tumors...
  21. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2007
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical! diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  22. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2004
    The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical! diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," the real ..
  23. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2005
    The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical! diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," the real ..
  24. Optical Biopsy sing Optical Coherence Tomography
    JAMES FUJIMOTO; Fiscal Year: 2006
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical! diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  25. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2010
    The use of diagnostic imaging has increased dramatically over the last 10 years. Concurrently, spectacular advances in imaging technology have allowed the detection of increasingly smaller anatomic lesions...
  26. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2009
    The use of diagnostic imaging has increased dramatically over the last 10 years. Concurrently, spectacular advances in imaging technology have allowed the detection of increasingly smaller anatomic lesions...
  27. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    ..The mainstay of diagnostic imaging in dental practices today is dental radiography (x-ray), which was first used in dentistry in 1885...
  28. In vivo imaging agents targeting Tau aggregates
    HANK KUNG; Fiscal Year: 2007
    ..The objective of this project is to develop potential F-18 and I-123 labeled diagnostic imaging agents, which specifically detect tangles (tau aggregates) in the brain using positron emission tomography (..
  29. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2005
    ..He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality...
  30. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2001
    ..He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality...
  31. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2002
    ..He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality...
  32. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2004
    ..He aims to improve patient care by expanding the boundaries of MRI from a diagnostic imaging to a treatment guidance modality...
  33. Preclinical Diagnostic Imaging of Amyloid
    Jonathan S Wall; Fiscal Year: 2010
    ....
  34. Preclinical Diagnostic Imaging of Amyloid
    Jonathan Wall; Fiscal Year: 2009
    ....
  35. Metabolism in the Heart by NMR
    A Dean Sherry; Fiscal Year: 2010
    ..measure absolute flux through important pathways such as this in vivo would not only revolutionize clinical diagnostic imaging but also serve as an important tool to better understand the metabolic effects of new drugs aimed to combat ..
  36. Metabolism in the Heart by NMR
    A Dean Sherry; Fiscal Year: 2009
    ..measure absolute flux through important pathways such as this in vivo would not only revolutionize clinical diagnostic imaging but also serve as an important tool to better understand the metabolic effects of new drugs aimed to combat ..
  37. DNA-modulated release of drug from melanoma targeting NP
    Kit Lam; Fiscal Year: 2009
    ..In this R21 application we shall develop this novel nanotherapeutic approach in a melanoma xenograft model. ..
  38. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    b>Diagnostic imaging requires the sufficient intensity of a corresponding signal from an area of interest in order to obtain diagnostically significant images...
  39. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2004
    b>Diagnostic imaging requires the sufficient intensity of a corresponding signal from an area of interest in order to obtain diagnostically significant images...
  40. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2005
    b>Diagnostic imaging requires the sufficient intensity of a corresponding signal from an area of interest in order to obtain diagnostically significant images...
  41. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2003
    b>Diagnostic imaging requires the sufficient intensity of a corresponding signal from an area of interest in order to obtain diagnostically significant images...
  42. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2000
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  43. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  44. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1999
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  45. CANCER IMMUNOTHERAPEUTICS PROGRAM
    Andrew Raubitschek; Fiscal Year: 2003
    ..The specific aims are: (a) to develop genetically engineered antibody constructs as diagnostic imaging agents directed against CEA, Her2, and PSCA (prostate stem cell antigen); (b) to apply genetically ..
  46. Implementation and Evaluation of Imaging Decision Support Incorporating CER
    G Scott Gazelle; Fiscal Year: 2010
    ..However, these advances are not without costs: diagnostic imaging represents a large and growing portion of total health care spending in the U.S...
  47. Development of Thermoacoustic Tomography Brain Imaging
    Mark A Anastasio; Fiscal Year: 2010
    ..is a rapidly emerging ultrasound-mediated hybrid imaging modality that promises to have a major impact on diagnostic imaging. TAT combines high ultrasonic resolution and strong microwave contrast in a single hybrid modality...
  48. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1992
    ....
  49. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1993
    ....
  50. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    KAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010
    ....
  51. Development of New Molecular Probes for Diagnostic Imaging of Atherosclerosis
    Karen Briley Saebo; Fiscal Year: 2009
    ....
  52. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    BRUCE DALE WEINTRAUB; Fiscal Year: 2010
    ..co-inventor and co-developer with Genzyme of wild type recombinant hTSH (Thyrogen), currently approved for diagnostic imaging of thyroid cancer, now proposes to develop novel radiolabeled high affinity hTSH analogs and/or analog-..
  53. Development of Superagonist Analogs of Recombinant Human TSH for Imaging and Ther
    Bruce Weintraub; Fiscal Year: 2009
    ..generation superactive analog of rh TSH for the 15-20% of poorly responsive thyroid cancer patients in diagnostic imaging as well as for the majority of such patients for radioiodine therapy...
  54. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2004
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  55. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2005
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  56. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2003
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  57. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward H Wong; Fiscal Year: 2010
    ..second generation of cross-bridged chelators for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer...
  58. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2009
    ..second generation of cross-bridged chelators for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer...
  59. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2007
    ..second generation of cross-bridged chelators for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer...
  60. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2007
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  61. Radiopharmaceuticals based on Cross-bridged Ligands
    Edward Wong; Fiscal Year: 2009
    ..second generation of cross-bridged chelators for copper-, indium- and gallium-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of cancer...
  62. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2002
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  63. Radiation Exposure from Medical Imaging: are Doses in the Carcinogenic Range?
    Rebecca Smith Bindman; Fiscal Year: 2009
    ..Using this large, population-based database, we will describe patterns of diagnostic imaging over time, estimate temporal trends in radiation doses associated with imaging, and determine factors ..
  64. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2006
    ..Magnetic resonance imaging (MRI) is crucial in the diagnostic imaging evaluation of neuroblastoma, however, no neuroblastoma-specific MRI contrast agents currently exist...
  65. Multispectral diagnostic imaging of the iris
    ANA LUKIC; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): The objective of this project is to develop a prototype of a new diagnostic imaging device for use by eye care practitioners...
  66. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2000
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  67. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2002
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  68. STAGING AND MONITORING MUSCULOSKELETAL SARCOMAS
    Leanne Seeger; Fiscal Year: 1991
    ..to the Request for Applications for cooperative agreement RFA number 90-CA-05, National Collaborative Diagnostic Imaging Trial Projects, National Cancer Institute...
  69. Automated Radiation Monitoring and Decision Support to Reduce Cumulative Exposure
    Aaron Sodickson; Fiscal Year: 2010
    ..Rapidly increasing utilization of diagnostic imaging - and in particular computed tomography (CT) - has markedly increased radiation exposure to the population, ..
  70. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2001
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  71. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 1999
    ..The hypothesis of this proposal is that optical coherence tomography, a new optical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  72. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    JAMES FUJIMOTO; Fiscal Year: 2003
    ..The hypothesis of this proposal is that optical coherence tomography (OCT), an emerging biomedical diagnostic imaging technology for in situ imaging of tissue microstructure, can be developed and applied for "optical biopsy," ..
  73. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    Bruce Frankel; Fiscal Year: 2009
    Despite significant improvements in diagnostic imaging and neurosurgical techniques, the current treatment modalities for high-grade gliomas are inadequate...
  74. Multispectral diagnostic imaging of the iris
    ANA LUKIC; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): The objective of this project is to develop a prototype of a new diagnostic imaging device for use by eye care practitioners...