blood flow velocity

Summary

Summary: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.

Top Publications

  1. ncbi Wave propagation in a model of the arterial circulation
    J J Wang
    Physiological Flow Studies Group, Department of Bioengineering, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    J Biomech 37:457-70. 2004
  2. pmc Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing
    Philip N Ainslie
    Department of Physiology, University of Otago, Dunedin, New Zealand
    J Physiol 586:4005-10. 2008
  3. ncbi A general kinetic model for quantitative perfusion imaging with arterial spin labeling
    R B Buxton
    Department of Radiology, University of San Diego, California, USA
    Magn Reson Med 40:383-96. 1998
  4. ncbi Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients
    Bruno Pannier
    Service d Hemodialyse, Hôpital F H Manhès, Paris, France
    Hypertension 45:592-6. 2005
  5. ncbi Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review
    Marina Cecelja
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, London, United Kingdom
    Hypertension 54:1328-36. 2009
  6. pmc Interaction between alk1 and blood flow in the development of arteriovenous malformations
    Paola Corti
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Development 138:1573-82. 2011
  7. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
  8. ncbi Arterial wave reflections and survival in end-stage renal failure
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, Ste Genevieve des Bois, France
    Hypertension 38:434-8. 2001
  9. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
  10. ncbi Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure
    Gert Reiter
    Siemens Medical Solutions, Graz, Austria
    Circ Cardiovasc Imaging 1:23-30. 2008

Detail Information

Publications321 found, 100 shown here

  1. ncbi Wave propagation in a model of the arterial circulation
    J J Wang
    Physiological Flow Studies Group, Department of Bioengineering, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    J Biomech 37:457-70. 2004
    ..We conclude from these calculations that the complex pattern of wave propagation in the large arteries may be the most important determinant of arterial haemodynamics...
  2. pmc Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing
    Philip N Ainslie
    Department of Physiology, University of Otago, Dunedin, New Zealand
    J Physiol 586:4005-10. 2008
    ..We examined how regular aerobic exercise affects the age-related decline in blood flow velocity in the middle cerebral artery (MCAv) in healthy humans...
  3. ncbi A general kinetic model for quantitative perfusion imaging with arterial spin labeling
    R B Buxton
    Department of Radiology, University of San Diego, California, USA
    Magn Reson Med 40:383-96. 1998
    ..In preliminary experiments with a human subject, the model provided a good description of pulsed ASL data during a simple sensorimotor activation task...
  4. ncbi Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients
    Bruno Pannier
    Service d Hemodialyse, Hôpital F H Manhès, Paris, France
    Hypertension 45:592-6. 2005
    ....
  5. ncbi Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review
    Marina Cecelja
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, St Thomas Hospital, London, United Kingdom
    Hypertension 54:1328-36. 2009
    ..The prognostic value of cfPWV may relate to a process of arterial ageing unrelated to classic risk factors other than hypertension...
  6. pmc Interaction between alk1 and blood flow in the development of arteriovenous malformations
    Paola Corti
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Development 138:1573-82. 2011
    ....
  7. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  8. ncbi Arterial wave reflections and survival in end-stage renal failure
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, Ste Genevieve des Bois, France
    Hypertension 38:434-8. 2001
    ..16 to 1.90; P<0.0001) for CV mortality. These results provide the first direct evidence that in ESRF patients increased effect of arterial wave reflections is an independent predictor of all-cause and CV mortality...
  9. ncbi Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
    ....
  10. ncbi Magnetic resonance-derived 3-dimensional blood flow patterns in the main pulmonary artery as a marker of pulmonary hypertension and a measure of elevated mean pulmonary arterial pressure
    Gert Reiter
    Siemens Medical Solutions, Graz, Austria
    Circ Cardiovasc Imaging 1:23-30. 2008
    ..Such pathological altered pressures in the pulmonary vascular system should lead to changes in blood flow patterns in the main pulmonary artery...
  11. ncbi Brachial-ankle pulse wave velocity: an index of central arterial stiffness?
    J Sugawara
    Institute for Human Science and Bioengineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    J Hum Hypertens 19:401-6. 2005
    ..These results suggest that baPWV may provide qualitatively similar information to those derived from central arterial stiffness although some portions of baPWV may be determined by peripheral arterial stiffness...
  12. ncbi Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model
    Joanna L Stanley
    Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 59:1021-8. 2012
    ..COMT(-/-) mice also demonstrated abnormal umbilical Doppler waveforms, including reverse arterial blood flow velocity. This was normalized after treatment with Sildenafil...
  13. ncbi The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma
    Doreen Schmidl
    Department of Clinical Pharmacology, Medical University of Vienna, Austria
    Exp Eye Res 93:141-55. 2011
    ..Indeed there is data indicating that reduction of IOP by pharmacological intervention improves optic nerve head blood flow regulation independently of an ocular vasodilator effect...
  14. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
    ....
  15. pmc Comprehensive 4D velocity mapping of the heart and great vessels by cardiovascular magnetic resonance
    Michael Markl
    Department of Radiology, Medical Physics, University Hospital Freiburg, Germany
    J Cardiovasc Magn Reson 13:7. 2011
    ..In this article, methods used for the acquisition, visualization, and quantification of such datasets are reviewed and illustrated...
  16. ncbi Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow
    Hasan Turhan
    Inonu University Medical Faculty, Department of Cardiology, Malatya, Turkey
    Int J Cardiol 108:224-30. 2006
    ....
  17. ncbi Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity
    Juan R Cebral
    School of Computational Sciences, George Mason University, 4400 University Drive, MSN 4C7, Fairfax, VA 22030, USA
    IEEE Trans Med Imaging 24:457-67. 2005
    ..We conclude that with the proposed modeling pipeline clinical studies involving large numbers cerebral aneurysms are feasible...
  18. ncbi Experimental validation of a time-domain-based wave propagation model of blood flow in viscoelastic vessels
    David Bessems
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 41:284-91. 2008
    ....
  19. ncbi Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
    Caroline Cheng
    Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Circulation 113:2744-53. 2006
    ..However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies...
  20. ncbi Wall shear stress--an important determinant of endothelial cell function and structure--in the arterial system in vivo. Discrepancies with theory
    Robert S Reneman
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 43:251-69. 2006
    ..Applications of wall shear stress as in flow-mediated arterial dilation, clinically in use to assess endothelial cell (dys)function, are also addressed. This review starts with some background considerations and some theoretical aspects...
  21. pmc Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 7:655-60. 2010
    ..Furthermore, we show that subpopulations of vessels, classified by functional parameters, exist in and around a tumor and in normal brain tissue...
  22. ncbi Applications of phase-contrast flow and velocity imaging in cardiovascular MRI
    Peter D Gatehouse
    Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London, UK
    Eur Radiol 15:2172-84. 2005
    ..The review includes phase-contrast applications in cardiac function, heart valves, congenital heart diseases, major blood vessels, coronary arteries and myocardial wall velocity...
  23. ncbi Quantitative 2D and 3D phase contrast MRI: optimized analysis of blood flow and vessel wall parameters
    A F Stalder
    Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany
    Magn Reson Med 60:1218-31. 2008
    ..Initial results in a patient with atherosclerosis suggest the potential of the method for understanding the formation and progression of cardiovascular diseases...
  24. ncbi Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study
    Heikki Aatola
    Department of Clinical Physiology, Tampere University Hospital, PO Box 2000, FI 33521 Tampere, Finland
    Hypertension 55:806-11. 2010
    ..These results support efforts for a reduction of conventional risk factors both in childhood and adulthood in the primary prevention of atherosclerosis...
  25. pmc Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal Study of Parents and Children (ALSPAC)
    Ann E Donald
    Vascular Physiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Eur Heart J 31:1502-10. 2010
    ..To assess the feasibility and reproducibility of non-invasive vascular assessment in a childhood population setting and identify the determinants of vascular phenotype in early life...
  26. ncbi Dynamic autoregulation testing in patients with middle cerebral artery stenosis
    C Haubrich
    Department of Neurology, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Stroke 34:1881-5. 2003
    Cross-spectral analysis (CSA) of spontaneous oscillations in cerebral blood flow velocity (CBFV) and arterial blood pressure is considered a sensitive and convenient method for dynamic autoregulation testing...
  27. pmc Time-resolved vessel-selective digital subtraction MR angiography of the cerebral vasculature with arterial spin labeling
    Philip M Robson
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Ansin 242, Boston, MA 02215, USA
    Radiology 257:507-15. 2010
    ....
  28. pmc Physical exercise, fitness and dietary pattern and their relationship with circadian blood pressure pattern, augmentation index and endothelial dysfunction biological markers: EVIDENT study protocol
    Luís García-Ortiz
    La Alamedilla Health Centre, Castilla y León Health Service SACYL, Salamanca, Spain
    BMC Public Health 10:233. 2010
    ....
  29. ncbi Spontaneous fluctuations in cerebral blood flow regulation: contribution of PaCO2
    R B Panerai
    Medical Physics Group, Department of Cardiovascular Sciences, University of Leicester National Health Service Trust, Leicester, UK
    J Appl Physiol (1985) 109:1860-8. 2010
    ..Continuous bilateral recordings of cerebral blood flow velocity (transcranial Doppler, middle cerebral artery), end-tidal Pco(2) (Pet(CO(2)), infrared capnograph), and ..
  30. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
    ..Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure...
  31. pmc Arterial stiffness is associated with incident albuminuria and decreased glomerular filtration rate in type 2 diabetic patients
    Ryotaro Bouchi
    Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Diabetes Care 34:2570-5. 2011
    ..To investigate the association between aortic stiffness and incident albuminuria and the decline in estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes...
  32. ncbi Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures
    S F Nagueh
    Baylor College of Medicine and Department of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 30:1527-33. 1997
    ....
  33. ncbi Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise
    Philip N Ainslie
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Heart Circ Physiol 292:H976-83. 2007
    ..Modelflow), muscle and cerebral oxygenation (near-infrared spectroscopy), and middle cerebral artery blood flow velocity (MCAV; transcranial Doppler ultrasound) were measured continuously...
  34. pmc Flow measurement by cardiovascular magnetic resonance: a multi-centre multi-vendor study of background phase offset errors that can compromise the accuracy of derived regurgitant or shunt flow measurements
    Peter D Gatehouse
    CMR Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 12:5. 2010
    ..We studied the severity of uncorrected velocity offset errors across sites and CMR systems...
  35. pmc Evaluation of 3D blood flow patterns and wall shear stress in the normal and dilated thoracic aorta using flow-sensitive 4D CMR
    Jonas Bürk
    Department of Diagnostic Radiology, Medical Physics, University Hospital, Freiburg, Germany
    J Cardiovasc Magn Reson 14:84. 2012
    ..The purpose of this study was to investigate 3D flow patterns and vessel wall parameters in patients with dilated ascending aorta, age-matched subjects, and healthy volunteers...
  36. ncbi Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease
    Michinari Nakamura
    Department of Cardiology, The Cardiovascular Institute, 7 3 10 Roppongi, Minato ku, Tokyo, Japan
    Hypertens Res 33:1018-24. 2010
    ....
  37. pmc Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness
    Julie Makani
    Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
    Br J Haematol 145:529-32. 2009
    High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO(2)) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear...
  38. ncbi Dynamic autoregulation testing in the posterior cerebral artery
    C Haubrich
    Department of Neurology, University Hospital Aachen, Pauwelsstrasse 31, 52074 Aachen, Germany
    Stroke 35:848-52. 2004
    ..encephalopathy, suggest a higher vulnerability of autoregulation within posterior parts of the brain, we investigated whether the cerebral blood flow velocity (CBFV) is modulated differently within the posterior cerebral artery (PCA).
  39. ncbi Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study
    Fernando Galassi
    Departments of Oto Neuro Ophthalmological Surgery and Statistics, University of Florence, Italy
    Arch Ophthalmol 121:1711-5. 2003
    ..To evaluate the effect of optic nerve circulation, using color Doppler imaging (CDI), on the progression of visual field damage in primary open-angle glaucoma...
  40. ncbi Potential role of size and hemodynamics in the efficacy of vascular-targeted spherical drug carriers
    Phapanin Charoenphol
    Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Biomaterials 31:1392-402. 2010
    ..Overall, the presented data suggests that spheres 2-5 microm in size are optimal for targeting the wall in medium to large vessels relevant in several cardiovascular diseases...
  41. ncbi Ocular blood flow assessment using continuous laser Doppler flowmetry
    Charles E Riva
    Department of Ophthalmology Dir Prof Emilio Campos, University of Bologna, Italy
    Acta Ophthalmol 88:622-9. 2010
    ..Various problems still need to be solved in order to bring to light the full potential of LDF in the assessment of microcirculatory haemodynamics...
  42. ncbi Emerging trends in CV flow visualization
    Partho P Sengupta
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    JACC Cardiovasc Imaging 5:305-16. 2012
    ..Finally, we discuss the potential clinical applications and technical challenges with suggestions for further investigations...
  43. pmc The cerebrovascular response to carbon dioxide in humans
    A Battisti-Charbonney
    Department of Physiology, Medical Sciences Building, 1 King s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Physiol 589:3039-48. 2011
    ..5 to 46.8 mmHg). We concluded that in the MCAv response range below the threshold for the increase of MAP with CO2, the MCAv measurement reflects vascular reactivity to CO2 alone at a constant MAP...
  44. ncbi Aortic pulse wave velocity index and mortality in end-stage renal disease
    Jacques Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Kidney Int 63:1852-60. 2003
    ..Nevertheless, because age, blood pressure, heart rate, and gender are strong determinants of both arterial stiffness and mortality, the individual relevance of PWV measurements remains controversial...
  45. ncbi Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans
    Hsiao D Lieu
    Portola Pharmaceuticals, South San Francisco, Calif, USA
    J Nucl Cardiol 14:514-20. 2007
    ..This study characterized the dose dependence of regadenoson-induced coronary hyperemia...
  46. ncbi Relationship between optic nerve head and finger blood flow
    Maneli Mozaffarieh
    University Eye Clinic, Basel, Switzerland
    Eur J Ophthalmol 20:136-41. 2010
    ..To examine the relationship between optic nerve head (ONH) and finger blood flow in subjects with and without a primary vascular dysregulation (PVD)...
  47. ncbi Comparative velocity investigations in cerebral arteries and aneurysms: 3D phase-contrast MR angiography, laser Doppler velocimetry and computational fluid dynamics
    Dorothea I Hollnagel
    Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland
    NMR Biomed 22:795-808. 2009
    ....
  48. ncbi Maladaptive aortic properties in children after palliation of hypoplastic left heart syndrome assessed by cardiovascular magnetic resonance imaging
    Inga Voges
    Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital of Schleswig Holstein, Kiel, Germany
    Circulation 122:1068-76. 2010
    ..Therefore, we assessed the anatomy, elastic properties, and viability of the aorta and right ventricular function in patients with hypoplastic left heart syndrome by cardiovascular magnetic resonance imaging...
  49. pmc The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function
    Kyra E Pyke
    Human Vascular Control Laboratory, School of Physical and Health Education, Queen s University, Kingston, ON, Canada
    J Physiol 568:357-69. 2005
    ....
  50. ncbi Effects of acute hypercapnia on the amplitude of cerebrovascular pulsation in humans registered with a non-invasive method
    Andrzej F Frydrychowski
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 83:229-36. 2012
    ..The aim of the study was to assess non-invasively the effects of acute hypercapnia on the amplitude of cerebrovascular pulsation (CVP) in humans...
  51. ncbi Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits
    Andrzej F Frydrychowski
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:156-62. 2011
    This study was performed: 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBF(ICA)) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance.
  52. ncbi Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment
    J R Cebral
    Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030, USA
    AJNR Am J Neuroradiol 32:27-33. 2011
    ..We analyzed 7 cases of aneurysms treated with flow diversion to explore the possible rupture mechanisms...
  53. ncbi Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels
    René M Werkmeister
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Opt Lett 33:2967-9. 2008
    ..We demonstrate that bidirectional color Doppler optical coherence tomography allows for the measurement of absolute blood flow values in vivo in human retinal vessels...
  54. ncbi Effects of the Valsalva maneuver on pial artery pulsation and subarachnoid width in healthy adults
    Magdalena Wszedybyl-Winklewska
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:369-73. 2011
    ....
  55. ncbi Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock
    Vanina S Kanoore Edul
    Servicio de Terapia Intensiva, Sanatorio Otamendi y Miroli, Buenos Aires, Argentina
    Crit Care Med 40:1443-8. 2012
    ..Our hypotheses were that 1) hyperdynamic blood flow is absent in septic shock; 2) nonsurvivors show more severe alterations than survivors; and 3) quantitative and semiquantitative microcirculatory parameters have a similar performance...
  56. pmc Determination of comprehensive arterial blood inflow in abdominal-pelvic organs: impact of respiration and posture on organ perfusion
    Takuya Osada
    Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, Japan
    Med Sci Monit 17:CR57-66. 2011
    ..However, little information exists regarding the influence of respiration (interplay between inspiration and expiration) and posture on BFAP...
  57. pmc Noninvasive measurements and analysis of blood velocity profiles in human retinal vessels
    Zhangyi Zhong
    School of Optometry, Indiana University, Bloomington, Indiana 47405 3635, USA
    Invest Ophthalmol Vis Sci 52:4151-7. 2011
    ..To quantitatively model the changes in blood velocity profiles for different cardiac phases in human retinal vessels...
  58. pmc In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth
    Junjie Yao
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
    Opt Lett 35:1419-21. 2010
    ..By measuring bovine blood flowing through a plastic tube, the linear dependence of the broadening on the flow speed was validated. The blood flow of the microvasculature in a mouse ear and a chicken embryo (stage 16) was also studied...
  59. ncbi Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke
    Nozomi Nishimura
    Department of Physics, University of California at San Diego, La Jolla, California 92093, USA
    Nat Methods 3:99-108. 2006
    ..This demonstrates that a single blockage to a microvessel can lead to local cortical ischemia. Lastly, we show that hemodilution leads to a restoration of flow in secondary downstream vessels...
  60. ncbi Systemic and microcirculatory responses to progressive hemorrhage
    Arnaldo Dubin
    Facultad de Ciencias Medicas, Cátedra de Farmacología Aplicada, Universidad Nacional de La Plata, La Plata, Argentina
    Intensive Care Med 35:556-64. 2009
    ..To compare systemic hemodynamics with microcirculatory changes at different vascular beds during progressive hemorrhage...
  61. ncbi Accelerated phase-contrast MR imaging: comparison of k-t BLAST with SENSE and Doppler ultrasound for velocity and flow measurements in the aorta
    Andreas Stadlbauer
    MR Physics Group, Department of Radiology, Landesklinikum St Poelten, Austria
    J Magn Reson Imaging 29:817-24. 2009
    ..To evaluate differences in velocity and flow measurements in the aorta between accelerated phase-contrast (PC) magnetic resonance imaging (MRI) using SENSE and k-t BLAST and in peak velocity to Doppler ultrasound...
  62. ncbi The critical role of hemodynamics in the development of cerebral vascular disease
    Alexander M Nixon
    Department of Vascular Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosurg 112:1240-53. 2010
    ..The recognition of WSS as an important factor in cerebral vascular disease may help to identify individuals at risk and guide treatment options...
  63. pmc Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans
    Alban Redheuil
    Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Hypertension 55:319-26. 2010
    ..In particular, compared with other measures of aortic function, the best markers of subclinical large artery stiffening, were AA distensibility in younger and aortic arch pulse wave velocity in older individuals...
  64. doi Calcific aortic stenosis--time to look more closely at the valve
    Catherine M Otto
    N Engl J Med 359:1395-8. 2008
  65. ncbi RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size
    Miyuki Unekawa
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1320:69-73. 2010
    ..319bpm) and arterial blood pressure (86 vs. 84mmHg). We speculate that physical factors relating to oxygen exchange may constrain general RBC velocity in capillaries to a certain range for optimum oxygen exchange, regardless of species...
  66. ncbi Lateralization of cerebral blood flow velocity changes during cognitive tasks. A simultaneous bilateral transcranial Doppler study
    G Vingerhoets
    Department of Psychiatry, University Ghent, Ghent, Belgium
    Stroke 30:2152-8. 1999
    Transcranial Doppler ultrasonography (TCD) permits the assessment of cognitively induced cerebral blood flow velocity (BFV) changes...
  67. ncbi Plasma fatty acid composition as a predictor of arterial stiffness and mortality
    Simon G Anderson
    Division of Cardiovascular and Endocrine Sciences, University of Manchester Medical School, 46 Grafton St, Manchester, M13 9NT United Kingdom
    Hypertension 53:839-45. 2009
    ..The results are consistent with an effect of dietary sources of n-3 long-chain polyunsaturates influencing arterial stiffness and mortality...
  68. ncbi G6PD deficiency, absence of alpha-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia
    Francoise Bernaudin
    Reference Center for Sickle Cell Disease, Department of Pediatrics, Intercommunal Créteil Hospital, Creteil, France
    Blood 112:4314-7. 2008
    ..This study confirms the protective effect of alpha-thalassemia and shows for the first time that G6PD deficiency and hemolysis independently increase the risk of cerebral vasculopathy...
  69. ncbi Homogeneity of cardiac contraction despite physiological asynchrony of depolarization: a model study
    R C P Kerckhoffs
    Department of Biomedical Engineering, Eindhoven University of Technology, Whoog 4 105, P O Box 513, 5600 Eindhoven, The Netherlands
    Ann Biomed Eng 31:536-47. 2003
    ..The present finding may indicate that electromechanical delay times are heterogeneously distributed, such that a contraction in a normal heart is more synchronous than depolarization...
  70. ncbi Cerebral blood flow velocity asymmetry, neurobehavioral maturation, and the cognitive development of premature infants across the first two years
    Hadar Arditi
    Department of Psychology and the Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    J Dev Behav Pediatr 28:362-8. 2007
    ..Neonatal physiological measures that can serve as indicators of later development are therefore important for early evaluation and intervention...
  71. ncbi Blood-flow volume quantification in internal carotid and vertebral arteries: comparison of 3 different ultrasound techniques with phase-contrast MR imaging
    S O Oktar
    Department of Radiology, School of Medicine, Gazi University, Besevler, Ankara, Turkey
    AJNR Am J Neuroradiol 27:363-9. 2006
    ....
  72. pmc Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases
    Yimin Wang
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:840-5. 2011
    ..To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT)...
  73. ncbi Autoregulation, a balancing act between supply and demand
    Josef Flammer
    University Eye Clinic Basel, Mittlere Str 91, Basel, Switzerland
    Can J Ophthalmol 43:317-21. 2008
    ..This instability, in turn, induces a repeated mild reperfusion injury. The resulting oxidative stress contributes to the pathogenesis of glaucomatous optic neuropathy...
  74. ncbi Reflux of jugular and retrobulbar venous flow in transient monocular blindness
    Hung Yi Hsu
    Section of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan
    Ann Neurol 63:247-53. 2008
    ..Transient monocular blindness (TMB) attacks may occur during straining activities that impede cerebral venous return. Disturbance of cerebral and orbital venous circulation may be involved in TMB...
  75. ncbi Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool?
    An L Moens
    Department of Cardiology, University of Antwerp, University Hospital of Antwerp, Wilrijkstraat 10, 2650 Antwerp, Belgium
    Chest 127:2254-63. 2005
    ..In this review article, the pathophysiology of FMD, based on reactive hyperemia, is extensively discussed. Furthermore, an overview is given of the actual clinical indications of FMD measurement...
  76. ncbi Measuring and interpreting ocular blood flow and metabolism in glaucoma
    Alon Harris
    Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA
    Can J Ophthalmol 43:328-36. 2008
    ....
  77. ncbi Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle
    Lucy H Clerk
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, 450 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    Diabetes 55:1436-42. 2006
    ..482, P = 0.027) in response to insulin. In conclusion, obesity eliminated the insulin-stimulated muscle microvascular recruitment and increased brachial artery blood flow seen in lean individuals...
  78. pmc Ocular blood flow alteration in glaucoma is related to systemic vascular dysregulation
    M Emre
    University Eye Clinic, Basel, Switzerland
    Br J Ophthalmol 88:662-6. 2004
    ..To investigate the source of ocular blood flow alterations in glaucoma...
  79. ncbi Effect of postconditioning on coronary blood flow velocity and endothelial function in patients with acute myocardial infarction
    Xiao Jing Ma
    Department of Cardiology, Shandong Provincial Hospital of Shandong University, Jinan, China
    Scand Cardiovasc J 40:327-33. 2006
    To observe the effect of postconditioning on coronary blood flow velocity and endothelial function in acute myocardial infarction (AMI).
  80. ncbi Vascular endothelial function in patients with slow coronary flow
    Alpay Turan Sezgin
    Department of Cardiology, Inonu University, Malatya, Turkey
    Coron Artery Dis 14:155-61. 2003
    ..Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear...
  81. pmc Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts
    Zhong Dong Shi
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Ann Biomed Eng 39:1608-19. 2011
    ....
  82. ncbi Risk of stroke, transient ischemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stenosis
    Till Blaser
    Department of Neurology, University of Magdeburg, Magdeburg, Germany
    Stroke 33:1057-62. 2002
    ..We aimed to identify and determine the clinical relevance of parameters predictive of stroke recurrence and vessel occlusion before carotid endarterectomy...
  83. ncbi Unsteady and three-dimensional simulation of blood flow in the human aortic arch
    N Shahcheraghi
    Department of Mechanical and Aeronautical Engineering, Institute for Theoretical Dynamics, University of California, Davis 95616, USA
    J Biomech Eng 124:378-87. 2002
    ..Comparison of our numerical results with the localization of early atherosclerotic lesions broadly suggests preferential development of these lesions in regions of extrema (either maxima or minima) in wall shear stress and pressure...
  84. ncbi A fluorescein and indocyanine green angiographic study of choriocapillaris in age-related macular disease
    D Pauleikhoff
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Arch Ophthalmol 117:1353-8. 1999
    ..To examine the phenomenon of a prolonged choroidal filling phase (PCFP) as seen on fluorescein and indocyanine green (ICG) angiography in patients with early age-related macular disease (AMD)...
  85. pmc Capillary density and retinal diameter measurements and their impact on altered retinal circulation in glaucoma: a digital fluorescein angiographic study
    O Arend
    Department of Ophthalmology, Medical School of the Technical University of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Br J Ophthalmol 86:429-33. 2002
    ..The aim of the study was to elucidate the morphological source of decreased perfusion and increased resistance of the ocular circulation in NPG...
  86. ncbi Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique
    T Hozumi
    Division of Cardiology, Kobe General Hospital, Japan
    J Am Coll Cardiol 32:1251-9. 1998
    ....
  87. ncbi Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography
    R J Adams
    Department of Neurology, Medical College of Georgia, Augusta 30912 3200, USA
    N Engl J Med 339:5-11. 1998
    ..We used transcranial Doppler ultrasonography to identify children with sickle cell anemia who were at high risk for stroke and then randomly assigned them to receive standard care or transfusions to prevent a first stroke...
  88. pmc Brachial-ankle pulse wave velocity and rate of renal function decline and mortality in chronic kidney disease
    Szu Chia Chen
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin J Am Soc Nephrol 6:724-32. 2011
    ..The aim of this study was to investigate whether there was an independent association between brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, and renal function progression in CKD patients...
  89. ncbi Albuminuria is strongly associated with arterial stiffness, especially in diabetic or hypertensive subjects--a population-based study (Taichung Community Health Study, TCHS)
    Chiu Shong Liu
    Department of Family Medicine, China Medical University Hospital, and Department of Family Medicine, China Medical University, Taichung, Taiwan
    Atherosclerosis 211:315-21. 2010
    ..Limited information is available for the association between albuminuria and arterial stiffness in Chinese. We aimed to assess the association between albuminuria and arterial stiffness in a middle-aged population-based study...
  90. ncbi Coronary endothelial vasomotor function and vascular remodeling in heart transplant recipients randomized for tacrolimus or cyclosporine immunosuppression
    Paraskevi Petrakopoulou
    Medizinische Klinik und Poliklinik I, Ludwig Maximilians University of Munich, Munich, Germany
    J Am Coll Cardiol 47:1622-9. 2006
    ..This study aimed to compare changes in coronary endothelial function, systemic endothelin-1 (ET-1) levels, and vascular remodeling in heart transplant recipients randomized to cyclosporin A (CyA) or tacrolimus (Tac) immunosuppression...
  91. ncbi Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement
    Thomas Weber
    Cardiology Department, Klinikum Wels Grieskirchen, Grieskirchnerstrasse 42, Wels 4600, Austria
    J Hypertens 27:1624-30. 2009
    ..The aim of our study was to compare cfPWV, calculated with commonly used noninvasive methods for travel distance assessment, against aortic PWV measured invasively...
  92. ncbi Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI
    Heynric B Grotenhuis
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 30:521-6. 2009
    ..To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV(MRI)) with PWV determined from invasive intra-aortic pressure measurements (PWV(INV)) and to test the reproducibility of the measurement by MRI...
  93. ncbi Color Doppler imaging in ocular hypertension and open-angle glaucoma
    Cengiz Akarsu
    Department of Ophthalmology, University of Kirikkale, Kirikkale, 71100, Turkey
    Graefes Arch Clin Exp Ophthalmol 242:125-9. 2004
    ..To quantify the retrobulbar hemodynamics of patients with ocular hypertension and open-angle glaucoma and to compare it with that of normal subjects...
  94. ncbi Finite element modeling of three-dimensional pulsatile flow in the abdominal aorta: relevance to atherosclerosis
    C A Taylor
    Department of Surgery, Stanford University, CA, USA
    Ann Biomed Eng 26:975-87. 1998
    ..Monogr. Atheroscler. 15:13-19, 1990). This numerical investigation provides detailed quantitative data on hemodynamic conditions in the abdominal aorta heretofore lacking in the study of the localization of atherosclerotic disease...
  95. ncbi Cardiac output and central distribution of blood flow in the human fetus
    G Mielke
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    Circulation 103:1662-8. 2001
    ..The objectives of this study were to establish reference ranges for left and right cardiac output and to investigate blood flow distribution through the foramen ovale, ductus arteriosus, and pulmonary bed in human fetuses...
  96. pmc Chronic optical access through a polished and reinforced thinned skull
    Patrick J Drew
    Department of Physics, University of California at San Diego, San Diego, California, USA
    Nat Methods 7:981-4. 2010
    ..We also repeatedly imaged dendritic spines, microglia and angioarchitecture, as well as used illumination to drive motor output via optogenetics and induce microstrokes via photosensitizers...
  97. ncbi Reproducibility of the blood flow index as noninvasive, bedside estimation of cerebral blood flow
    Bendicht P Wagner
    Pediatric Intensive Care, Department of Pediatrics, Inselspital, University of Berne, 3010, Berne, Switzerland
    Intensive Care Med 29:196-200. 2003
    ..To investigate the feasibility and reproducibility of the blood flow index (BFI) method for measuring cerebral blood flow...
  98. ncbi Use of laser speckle flowgraphy in ocular blood flow research
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Japan
    Acta Ophthalmol 88:723-9. 2010
    ..Unresolved issues concern the effect of pupil size on measurement results, the effects of various stimulations, and how to measure choroidal and retinal blood flow velocity separately without using the blue-component of argon laser.
  99. ncbi Elevated E/E' predicts prognosis in congestive heart failure patients with preserved systolic function
    Hiroyuki Okura
    Division of Cardiology, Bell Land General Hospital, Sakai, Japan
    Circ J 73:86-91. 2009
    ..The purpose of this study was to investigate whether E/E' predicts prognosis in HFPSF...
  100. ncbi Histomorphology of the placenta and the placental bed of growth restricted foetuses and correlation with the Doppler velocimetries of the uterine and umbilical arteries
    R Madazli
    Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    Placenta 24:510-6. 2003
    ..The most severe clinical outcomes and perinatal mortality are present when both uterine and umbilical districts are altered...
  101. ncbi Effect of antihypertensive agents on cerebral blood flow and flow velocity in acute ischaemic stroke: systematic review of controlled studies
    Gillian M Sare
    Stroke Trials Unit, Institute of Neuroscience, University of Nottingham, Nottingham, UK
    J Hypertens 26:1058-64. 2008
    ..Lowering blood pressure might improve outcome, provided it does not reduce cerebral blood flow in the presence of dysfunctional cerebral autoregulation...

Research Grants63

  1. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..Thus, effects of the Doppler angle in blood flow measurement are eliminated and the absolute blood flow velocity can be measured in real-time. Aim 3...
  2. Omega-3 Fatty Acids, Neurohumoral Activation, and Human Heart Failure
    Kevin D Monahan; Fiscal Year: 2010
    ..sympathetic nervous system outflow using peroneal microneurography, Doppler ultrasound estimates of renal blood flow velocity and whole limb blood flow, [central venous pressure], and numerous biochemical measures to assess the state ..
  3. WEARABLE SENSOR FOR CONTINUOUS NONINVASIVE MONITORING OF PULSE PRESSURE
    Sridhar Madala; Fiscal Year: 2010
    ..the skin over the carotid or brachial artery and will use pulsed Doppler ultrasound to continuously measure blood flow velocity, arterial diameter with a 1 micron resolution and local pulse transit times with 0.1 millisecond resolution...
  4. Exploring the Physiology of Short-term Control of Cerebral Blood Flow in Humans
    J Andrew Taylor; Fiscal Year: 2011
    ..Beat-by-beat assessment of cerebral blood flow velocity has shown that cerebral flow is regulated not just over minutes and hours but also on shorter time scales ..
  5. Hypertension, angiotensin receptor blockers, cognition: effects and mechanisms
    Ihab M Hajjar; Fiscal Year: 2013
    ..Candesartan was also associated with an increase in cerebral blood flow velocity that only reached significance in those with low flow velocity at baseline (n=23)...
  6. Neurodevelopmental Outcomes in Infants with HLHS after Hybrid Stage I Palliation
    Sharon L Hill; Fiscal Year: 2011
    ..objective of this research proposal is to test the hypothesis that a correlation exists between cerebral blood flow velocity and neurodevelopmental outcomes in hypoplastic left heart syndrome babies who have undergone Hybrid Stage I ..
  7. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..Cerebral blood flow velocity (CBFv) will be estimated by transcranial Doppler ultrasonography...
  8. Label-free optical imaging of 3D structural and functional microcirculations
    Ruikang Wang; Fiscal Year: 2012
    ..technique is based on the linear relationship between phase-changes in the optical fOMAG signals and the blood flow velocity when fOMAG images the tissue;3) Map the oxygenation status of the blood perfusion by a novel spectroscopic ..
  9. Modulating Ocular/Retinal Blood Flow and Visual Function in Retinitis Pigmentosa
    Ava K Bittner; Fiscal Year: 2013
    ..A significant increase in blood flow velocity and decreased vascular resistance was measured in the retrobulbar arteries during needling of vision-..
  10. Hydroxyurea to Prevent CNS Complications of Sickle Cell Disease in Children
    MICHAEL RUTLEDGE DEBAUN; Fiscal Year: 2012
    ..SCD include screening by transcranial Doppler ultrasound (TCD) to identify children with elevated cerebral blood flow velocity who are at increased risk for strokes;these children are then typically treated with chronic transfusions ..
  11. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2010
    ..soluble adhesion molecules known to be related to vascular injury (by real-time multiplex assay), and blood flow velocity and microvessel morphometry (by direct real-time computer-assisted intravital microscopy)...
  12. Nonlinear Dynamics of Frailty in Aging
    Lewis Lipsitz; Fiscal Year: 2013
    ..including cardiovascular (interbeat (RR) intervals and blood pressure (BP)), cerebrovascular (cerebral blood flow velocity (BFV)), respiratory (interbreath intervals), and balance (center-of-pressure trajectories) control systems...
  13. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..In particular, effects of blood flow velocity and/or percent stenosis and denudation on platelet accumulation will be studied...
  14. Doppler flow wires and hemodynamics in intracranial aneurysms
    LOUIS JOONG KIM; Fiscal Year: 2013
    ..b>Blood flow velocity within cerebral blood vessels, an important hemodynamic property in aneurysmal disease, is usually measured ..
  15. Pediatric CFS in a Community-Based Sample
    Leonard A Jason; Fiscal Year: 2013
    ..cerebral blood flow, which, we believe, are due to the differing ways of measuring the response of cerebral blood flow velocity to arterial pressure...
  16. Device for Measuring Capillary Blood Flow and the Onset of Shock
    David E Wolf; Fiscal Year: 2011
    ..Using correlation analysis, DCS extracts the characteristic time constants due to mean blood flow velocity. The device can also monitor heart rate, arterial or venal blood flow, and blood oxygenation...
  17. Stress, Parenting and Cognitive Function in Children with Sickle Cell Disease
    Bruce E Compas; Fiscal Year: 2013
    ..infarcts, chronic hypoxia due to anemia, acute hypoxia, nutritional deficits, increased peak cerebral blood flow velocity, and sleep disordered breathing/sleep apnea...
  18. VisualSonics Vevo 2100 Small Animal Ultrasound Imaging System and Accessories
    John A Hossack; Fiscal Year: 2010
    ..Doppler for sensitive imaging and quantification of perfusion, Pulsed-Wave Doppler for quantification of blood flow velocity. The scanner also possesses tissue tracking software to enable assessment and quantification of cardiac ..
  19. ROLE OF SEROTONIN IN PREGNANCY-RELATED HYPERTENSION
    Carl Weiner; Fiscal Year: 1992
    ..using guinea pigs chronically instrumented so that blood pressure, heart rate, cardiac output, and uterine blood flow velocity are measured in a continuous fashion...
  20. FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    Marcos Intaglietta; Fiscal Year: 2004
    ..of microvascular transport properties including micro-p02 and micro-NO measurements in blood and tissue, blood flow velocity, functional capillary density and arteriolar reactivity...
  21. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003
    ..born to mothers with chorioamnionitis have 1) decreased cardiac function and middle cerebral artery Doppler blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured by near infrared spectroscopy ..
  22. Cerebral Blood Flow Model for Normo/Hypertensive Elderly
    METTE OLUFSEN; Fiscal Year: 2002
    ..The specific aim is to develop a lumped parameter model that can reproduce a dynamic changes of pulsatile blood flow velocity (BFV) and pressure (BP) in the middle cerebral artery (MCA) during posture change from sitting to standing, ..
  23. COGNITIVE AND NEUROIMAGING STUDY OF SICKLE CELL ANEMIA
    Elias Melhem; Fiscal Year: 2001
    ..the relationship between proximal and distal parenchymal perfusion to test the hypothesis that as cerebral blood flow velocity in the individual major cerebral arteries increases, perfusion at the arteriolar/capillary level will ..
  24. POSTMENOPAUSAL HORMONE THERAPY IN UNSTABLE ANGINA
    Steven Schulman; Fiscal Year: 1999
    ..patients with atherosclerosis utilizing quantitative angiography and intracoronary doppler measurements of blood flow velocity suggest that endothelial dysfunction results in a paradoxical coronary vasoconstriction response to certain ..
  25. Optical Doppler tomography of human skin
    John Nelson; Fiscal Year: 2007
    ..Doppler Tomography (ODT) combines Doppler velocimetry with optical coherence tomography (OCT) to measure blood flow velocity at discrete user-specified locations in highly scattering biological tissues...
  26. Tyrosine Hydroxylase Sry and Hypertension
    Daniel Ely; Fiscal Year: 2009
    ..Blood pressure will be measured by telemetry and blood flow velocity by Doppler flow probe in conscious animals...
  27. ULTRASOUND ENHANCED THROMBOLYSIS AND MONITOR
    MARK MOEHRING; Fiscal Year: 2000
    ..This proposal comprises a platform for development of a Doppler ultrasound device which monitors cerebral blood flow velocity and concurrently enhances the thrombolytic effect of t-PA...
  28. IMPACT OF PAIN ON CEREBRAL BLOOD FLOW IN PRETERM INFANTS
    ROSALIE MAINOUS; Fiscal Year: 1999
    ..The purpose of this research is to describe the phenomena of cerebral blood flow velocity as a response to an acute nocioceptive event, the heel stick, which includes all phases of a heel stick ..
  29. SHEAR TO AORTIC HISTAMINE SYNTHESIS AND PERMEABILITY
    THEODORE HOLLIS; Fiscal Year: 1980
    ..above tissue preparations, will be examined following exposure to shearing stresses produced by changes in blood flow velocity induced by changes in the aortic lumenal diameter via an inserted balloon catheter...
  30. NON-INVASIVE EVALUATION OF ICP AND HEMODYNAMICS
    David Newell; Fiscal Year: 2004
    ..Transcranial Doppler (TCD) can be used to continuously record blood flow velocity from the intracranial vessels which then can be used in combination with arterial blood pressure (ABP) ..
  31. NON-INVASIVE EVALUATION OF ICP AND HEMODYNAMICS
    David Newell; Fiscal Year: 2002
    ..Transcranial Doppler (TCD) can be used to continuously record blood flow velocity from the intracranial vessels which then can be used in combination with arterial blood pressure (ABP) ..
  32. Tomographic Microscope for Assessing Microcirculation
    PAUL SHNITSER; Fiscal Year: 2005
    ..structure of the microcirculation network, the functional parameters of blood microcirculation such as a blood flow velocity and blood oxygen saturation, and tissue morphology...
  33. MICROVASCULAR MONITORING USING OPTICAL TECHNOLOGY
    J Nelson; Fiscal Year: 2003
    ..Doppler Tomography (ODT) combines Doppler velocimetry with optical coherence tomography (OCI) to measure blood flow velocity at discrete user-specified locations in highly scattering biological tissues...
  34. MICROVASCULAR MONITORING USING OPTICAL TECHNOLOGY
    J Nelson; Fiscal Year: 2001
    ..Doppler Tomography (ODT) combines Doppler velocimetry with optical coherence tomography (OCI) to measure blood flow velocity at discrete user-specified locations in highly scattering biological tissues...
  35. ULTRASONIC CONTRAST BLOOD FLOWMETRY
    K Shung; Fiscal Year: 1992
    ..1) Mean blood flow velocity will be estimated from a measurement of the time course of the variation in the ultrasonic attenuation of ..
  36. Effects of Vestibular Loss on Orthostatic Mechanisms
    Scott Wood; Fiscal Year: 2004
    ..rate, stroke volume, peripheral vascular resistance, end-tidal C02, respiratory rate and volume, cerebral blood flow velocity and cerebrovascular resistance will be measured during the tilt stimuli...
  37. TCD Assessment of Hemovelocity while Older Adults Think
    ALBERT ROBERTS; Fiscal Year: 2001
    ..three experiments will use a transcranial Doppler neuroimaging procedure to record bilateral cerebral blood flow velocity simultaneously while persons perform cognitive activities...
  38. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  39. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009
    ..The results of these studies will provide insight into the role of hemodynamic interactions with the microvessel wall and aid development of therapeutic strategies to treat ischemia and inflammation. ..
  40. Cerebromicrovascular disease in elderly with diabetes
    Vera Novak; Fiscal Year: 2010
    ..This study will provide new data and biomarkers on cerebral perfusion and functional outcomes in type 2 DM, that can be used to initialize the efforts to implement brain protection as a new target for prevention of DM complications. ..
  41. NEUROPATHOLOGY AND PATHOGENESIS OF HUNTINGTON' DISEASE
    Anton Reiner; Fiscal Year: 2004
    ....
  42. BASAL GANGLIA--ANATOMICAL AND FUNCTIONAL ORGANIZATION
    Anton Reiner; Fiscal Year: 2003
    ..g. Huntington's and Parkinson's disease), which may in turn make it possible to devise more effective preventive and therapeutic measures for such disorders. ..
  43. Mentored Patient-Oriented Research Career Development Aw
    Zhenqi Liu; Fiscal Year: 2004
    ....
  44. A central aortic pulse wave velocity measurement device
    Gary Mitchell; Fiscal Year: 2005
    ..This innovative technology will enable accurate diagnosis and risk stratification in a primary care setting and will facilitate further research aimed at evaluating interventions that may reduce conduit vessel stiffness. ..
  45. HARVARD OLDER AMERICANS INDEPENDENCE CENTER
    Lewis Lipsitz; Fiscal Year: 2006
    ..abstract_text> ..
  46. Development of Cerebral Autoregulation in VLBW Infants
    Jeffrey Kaiser; Fiscal Year: 2006
    ..Continuous 1-hour measurements of cerebral blood flow velocity (transcranial Doppler ultrasound) will be compared to simultaneous blood pressure measurements using ..
  47. Vascular Structure and Function with Aging
    Brad Behnke; Fiscal Year: 2008
    ..No page numbering necessary. Not to exceed 3 publications; 2 for predoctoral candidates.) E Check if Appendix is included ..
  48. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  49. HRCA/HARVARD RESEARCH NURSING HOME
    Lewis Lipsitz; Fiscal Year: 2008
    ..Our institutional commitments, longstanding collaboration among investigators, track record of productivity, administrative structure, and proven leadership all assure that this program will achieve its stated goals. ..
  50. Dynamical Assessment of Cerebral Autoregulation
    Vera Novak; Fiscal Year: 2007
    ..a new approach to quantify cerebral autoregulation from nonstationary blood pressure (BP) and cerebral blood flow velocity (BFV) fluctuations using transcranial Doppler ultrasound...
  51. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2008
    ..In addition, intradermal microdialysis will be combined with measurements of bioavailable NO by NO-selective amperometric electrode to define further how the NO system functions in cutaneous active vasodilation. ..
  52. Cerebral Vasoregulation In Elderly with Stroke
    Vera Novak; Fiscal Year: 2007
    ..To evaluate vasoreactivity to CO2 stimulus we will measure blood flow velocity (BFV) in both MCAs during hypo- and hypercapnia using transcranial Doppler ultrasound...
  53. CT DEVICE FOR MICROIMAGING OF TISSUE SPECIMENS IN VIVO
    Felix Wehrli; Fiscal Year: 2001
    ..abstract_text> ..
  54. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  55. Quantification of coronary calcium mass by dual energy fluoroscopy
    Sabee Molloi; Fiscal Year: 2009
    ..Dual-energy imaging, because of its motion insensitivity, can serve as a foundation for quantitative cardiac analysis to proceed. ..
  56. AIRWAY PARTICLE CLEARANCE--ROLE OF BRONCHIAL CIRCULATION
    Elizabeth Wagner; Fiscal Year: 2001
    ..Furthermore, the results will contribute to an understanding of the factors that both limit and enhance uptake and distribution of aerosols. ..
  57. Human Biology Association 2002 Annual Meeting
    LORNA MOORE; Fiscal Year: 2002
    ..abstract_text> ..
  58. A Data Fusion Method for Bedside Monitoring of Lumped Cerebral Arterial Radii
    Xiao Hu; Fiscal Year: 2008
    ..requires bedside measurements of arterial blood pressure (ABP), intracranial pressure (ICP) and cerebral blood flow velocity (CBFV)...
  59. Data Mining Based Noninvasive Intracranial Pressure Assessment
    Xiao Hu; Fiscal Year: 2008
    ..from a signal database that contains records of simultaneous arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) from a population of patients...
  60. HYPERTENSION, COGNITION, AND THE BRAIN IN OLDER ADULTS
    SHARI WALDSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  61. NMR IMAGING AND STEREOLOGIC ANALYSIS OF TRABECULAR BONE
    Felix Wehrli; Fiscal Year: 2009
    ..abstract_text> ..
  62. High Resolution Imaging Endoscopic Probe
    Nicusor Iftimia; Fiscal Year: 2006
    ..It is evident that earlier diagnosis results in an improved outcome, decreased morbidity and reduced mortality from disease. [unreadable] [unreadable] [unreadable]..