breath tests

Summary

Summary: Any tests done on exhaled air.

Top Publications

  1. pmc Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors
    G Peng
    Department of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Br J Cancer 103:542-51. 2010
  2. ncbi Exhaled nitric oxide in pulmonary diseases: a comprehensive review
    Peter J Barnes
    Airway Disease Section, Imperial College London, National Heart and Lung Institute, London, England
    Chest 138:682-92. 2010
  3. pmc Noninvasive detection of lung cancer by analysis of exhaled breath
    Amel Bajtarevic
    Department of Operative Medicine, Innsbruck Medical University, A 6020 Innsbruck, Austria
    BMC Cancer 9:348. 2009
  4. ncbi 13C-breath tests: current state of the art and future directions
    B Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Dig Liver Dis 39:795-805. 2007
  5. ncbi NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis
    Paolo Montuschi
    Department of Pharmacology, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 67:222-8. 2012
  6. ncbi Diagnosing lung cancer in exhaled breath using gold nanoparticles
    Gang Peng
    Department of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nat Nanotechnol 4:669-73. 2009
  7. ncbi Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome
    Derrick K Ong
    Department of Medicine, Eastern Health Clinical School, Monash University, Victoria, Australia
    J Gastroenterol Hepatol 25:1366-73. 2010
  8. pmc Dependence of exhaled breath composition on exogenous factors, smoking habits and exposure to air pollutants
    W Filipiak
    Breath Research Institute of the Austrian Academy of Sciences, Rathausplatz 4, A 6850 Dornbirn, Austria
    J Breath Res 6:036008. 2012
  9. ncbi A nanomaterial-based breath test for short-term follow-up after lung tumor resection
    Yoav Y Broza
    Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa, Israel
    Nanomedicine 9:15-21. 2013
  10. ncbi Volatile biomarkers of pulmonary tuberculosis in the breath
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024, USA
    Tuberculosis (Edinb) 87:44-52. 2007

Research Grants

Detail Information

Publications288 found, 100 shown here

  1. pmc Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors
    G Peng
    Department of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Br J Cancer 103:542-51. 2010
    ....
  2. ncbi Exhaled nitric oxide in pulmonary diseases: a comprehensive review
    Peter J Barnes
    Airway Disease Section, Imperial College London, National Heart and Lung Institute, London, England
    Chest 138:682-92. 2010
    ..Monitoring FeNO in pulmonary hypertension and cystic fibrosis has opened up a window to the role NO may play in their pathogenesis and possible clinical benefits in the management of these diseases...
  3. pmc Noninvasive detection of lung cancer by analysis of exhaled breath
    Amel Bajtarevic
    Department of Operative Medicine, Innsbruck Medical University, A 6020 Innsbruck, Austria
    BMC Cancer 9:348. 2009
    ..An early non-invasive diagnosis of lung cancer would improve prognosis and enlarge treatment options. Analysis of exhaled breath would be an ideal diagnostic method, since it is non-invasive and totally painless...
  4. ncbi 13C-breath tests: current state of the art and future directions
    B Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Dig Liver Dis 39:795-805. 2007
    13C-breath tests provide a non-invasive diagnostic method with high patient acceptance. In vivo, human and also bacterial enzyme activities, organ functions and transport processes can be assessed semiquantitatively using breath tests...
  5. ncbi NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis
    Paolo Montuschi
    Department of Pharmacology, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 67:222-8. 2012
    ..Metabolomics could provide new insights into the pathophysiology of cystic fibrosis (CF) by identifying profiles of endogenous metabolites...
  6. ncbi Diagnosing lung cancer in exhaled breath using gold nanoparticles
    Gang Peng
    Department of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nat Nanotechnol 4:669-73. 2009
    ..Our results show that sensors based on gold nanoparticles could form the basis of an inexpensive and non-invasive diagnostic tool for lung cancer...
  7. ncbi Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome
    Derrick K Ong
    Department of Medicine, Eastern Health Clinical School, Monash University, Victoria, Australia
    J Gastroenterol Hepatol 25:1366-73. 2010
    ..In the present study, we aimed to compare the patterns of breath hydrogen and methane and symptoms produced in response to diets that differed only in FODMAP content...
  8. pmc Dependence of exhaled breath composition on exogenous factors, smoking habits and exposure to air pollutants
    W Filipiak
    Breath Research Institute of the Austrian Academy of Sciences, Rathausplatz 4, A 6850 Dornbirn, Austria
    J Breath Res 6:036008. 2012
    ....
  9. ncbi A nanomaterial-based breath test for short-term follow-up after lung tumor resection
    Yoav Y Broza
    Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa, Israel
    Nanomedicine 9:15-21. 2013
    ..This indicates that the observed pattern is associated with the presence of malignant lung tumors. The proof-of-concept presented here has initiated a large-scale clinical study for post-surgery follow-up of LC patients...
  10. ncbi Volatile biomarkers of pulmonary tuberculosis in the breath
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024, USA
    Tuberculosis (Edinb) 87:44-52. 2007
    ..e. between normal controls and patients hospitalized for suspicion of pulmonary tuberculosis, and between infected versus non-infected patients i.e. between those whose sputum cultures were positive or negative for Mycobacteria...
  11. ncbi Breath biomarkers of active pulmonary tuberculosis
    Michael Phillips
    Menssana Research Inc, 1 Horizon Road, Suite 1415, Fort Lee, NJ 07024 6510, USA
    Tuberculosis (Edinb) 90:145-51. 2010
    ..Volatile organic compounds (VOCs) in breath may contain biomarkers of active pulmonary tuberculosis derived from the infectious organism (metabolites of Mycobacterium tuberculosis) and from the infected host (products of oxidative stress)...
  12. ncbi Exhaled nitric oxide: the effects of age, gender and body size
    K W Tsang
    University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Lung 179:83-91. 2001
    ..Men had significantly higher exhaled NO levels than women (p = 0.001). Although exhaled NO levels did not correlate with age (r = 0.12, p = 0.17), it correlated significantly with height (r = 0.23, p = 0.02), weight (r = 0.34, p..
  13. ncbi Breath carbon monoxide as an indication of smoking habit
    E T Middleton
    University of Sheffield, UK
    Chest 117:758-63. 2000
    ..To assess whether the breath carbon monoxide (CO) concentration can be used to determine a patient's smoking habits in a respiratory outpatient clinic...
  14. ncbi Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples
    Mona Syhre
    Otago University, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Med Mycol 46:209-15. 2008
    ..Breath analysis has the potential of being a non-invasive diagnostic method of detecting respiratory infection including invasive aspergillosis...
  15. ncbi Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease
    Christian Gessner
    Department of Respiratory Medicine, University of Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Respir Med 99:1229-40. 2005
    ..01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12. EBC analysis successfully characterized important differences in stable COPD compared to exacerbation or smoking and non-smoking healthy individuals...
  16. ncbi Diagnostic value of nasal nitric oxide measured with non-velum closure techniques for children with primary ciliary dyskinesia
    Dimas Mateos-Corral
    Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Pediatr 159:420-4. 2011
    ..Our objectives were to determine whether easier non-velum closure techniques have the ability to discriminate PCD and longitudinal reproducibility...
  17. pmc The effect of inhaled chromium on different exhaled breath condensate biomarkers among chrome-plating workers
    Andrea Caglieri
    Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Environ Health Perspect 114:542-6. 2006
    ..05). The results of this study demonstrate that EBC is a suitable matrix that can be used to investigate both Cr levels and biomarkers of free radical production sampling the epithelial-lining fluid of workers exposed to Cr(VI)...
  18. ncbi 13C-urea breath test for the diagnosis of Helicobacter pylori infection in children: a systematic review and meta-analysis
    Yelda A Leal
    Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad de Mérida, Instituto Mexicano del Seguro Social, Merida, Yuc, Mexico
    Helicobacter 16:327-37. 2011
    ..We aimed to carry out a systematic review and meta-analysis to evaluate the performance of the (13) C-UBT diagnostic test for H. pylori infection in children...
  19. ncbi The trends of one-week first-line and second-line eradication therapy for Helicobacter pylori infection in Korea
    Jun Won Chung
    Department of Internal Medicine, Gachon University, Gil Medical Center, Incheon
    Hepatogastroenterology 58:246-50. 2011
    ..The aim of this study was to evaluate 7-year changes in efficacy of one-week first line and second line therapies in Helicobacter pylori eradication rates in Korea...
  20. pmc Diagnosis of head-and-neck cancer from exhaled breath
    M Hakim
    The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, Haifa 32000, Israel
    Br J Cancer 104:1649-55. 2011
    ..Head-and-neck cancer sufferers often develop a second primary tumour that can affect the entire aero-digestive tract, mostly HNC or lung cancer (LC), making lifelong follow-up necessary...
  21. pmc Elevated airway purines in COPD
    Charles R Esther
    Department of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chest 140:954-60. 2011
    ..However, accurate airway surface purine measurements can be confounded by stimulation of purine release during collection of typical respiratory samples...
  22. ncbi The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study
    R H de Roest
    Department of Medicine, University of Otago, Christchurch, New Zealand
    Int J Clin Pract 67:895-903. 2013
    ..Fermentable oligo-, di-, mono-saccharides and polyols (FODMAPs) may trigger gastrointestinal symptoms in IBS patients. Our aim was to determine whether a low FODMAP diet improves symptoms in IBS patients...
  23. ncbi Physiological modeling of isoprene dynamics in exhaled breath
    Julian King
    Breath Research Institute, Austrian Academy of Sciences, Rathausplatz 4, A 6850 Dornbirn, Austria
    J Theor Biol 267:626-37. 2010
    ....
  24. ncbi Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
    ....
  25. ncbi Exhaled nitric oxide discriminates children with and without allergic sensitization in a population-based study
    T C Yao
    Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan
    Clin Exp Allergy 41:556-64. 2011
    ..Fraction of exhaled nitric oxide (FeNO) as a biomarker of airway inflammation in children warrants better clarification...
  26. ncbi Calcium and magnesium in exhaled breath condensate of children with endogenous and exogenous airway acidification
    S Banovic
    Department for Clinical Laboratory Diagnosis, Srebrnjak Children s Hospital, Zagreb, Croatia
    J Asthma 48:667-73. 2011
    ..e., with endogenous acidification) and children with gastroesophageal reflux disease, GERD (i.e., with exogenous acidification)...
  27. ncbi Comparability of a hand-held nitric oxide analyser with online and offline chemiluminescence-based nitric oxide measurement
    Barbara Schiller
    Division of Pediatric Intensive Care and Pulmonology, University Children s Hospital of Basel, Basel, Switzerland
    Pediatr Allergy Immunol 20:679-85. 2009
    ..FeNO values obtained using the chemiluminescence NO analyser, the portable NIOX MINO system and the offline collection technique show between-method agreement within clinically acceptable range...
  28. ncbi Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management
    Susan J Shepherd
    Department of Gastroenterology and Monash University, Victoria, Australia
    J Am Diet Assoc 106:1631-9. 2006
    ..01), as was improvement in individual symptoms (P<0.01 for all symptoms). This comprehensive fructose malabsorption dietary therapy achieves a high level of sustained adherence and good symptomatic response...
  29. ncbi High levels of interleukin-6 in the exhaled breath condensate of patients with COPD
    Enrica Bucchioni
    Institute of Respiratory Diseases, University of Milan, Ospedale Maggiore IRCCS, Via F Sforza, 35, Milano 20125, Italy
    Respir Med 97:1299-302. 2003
    ..Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of the respiratory tract...
  30. ncbi Point-of-care breath test for biomarkers of active pulmonary tuberculosis
    Michael Phillips
    Menssana Research Inc, Breath Research Laboratory, EDC III, 211 Warren Street, Newark, NJ 07103, USA
    Tuberculosis (Edinb) 92:314-20. 2012
    ..Volatile organic compounds (VOCs) in breath provide biomarkers of tuberculosis (TB) because Mycobacterium tuberculosis manufactures VOC metabolites that are detectable in the breath of infected patients...
  31. pmc Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancer
    Peter J Mazzone
    Respiratory Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Thorac Oncol 7:137-42. 2012
    ..Breath biosignature-based classification of homogeneous subgroups of lung cancer may be more accurate than a global breath signature. Combining breath biosignatures with clinical risk factors may improve the accuracy of the signature...
  32. pmc Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
    Oriol Roca
    Intensive Care Department General Area, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, C P 08035 Barcelona, Spain
    Crit Care 12:R72. 2008
    ..Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI...
  33. ncbi The recurrence of Helicobacter pylori infection: incidence and variables influencing it. A critical review
    Javier P Gisbert
    Department of Gastroenterology, University Hospital of La Princesa, Madrid, Spain
    Am J Gastroenterol 100:2083-99. 2005
    ..pylori eradication, recolonization of the gastric mucosa by the organism has almost always occurred...
  34. ncbi Lung clearance index in the assessment of airways disease
    Alex Horsley
    Department of Respiratory Medicine, Edinburgh Royal Infirmary, 51 Little France Crescent, Edinburgh EH4 2XU, United Kingdom
    Respir Med 103:793-9. 2009
    ..Thorax, 2008;63(2):96-7]. This review will consider how LCI is derived, how it differs from conventional lung function testing, and its applications and limitations...
  35. ncbi 13C-urea breath test to assess Helicobacter pylori bacterial load
    Rocco Maurizio Zagari
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Helicobacter 10:615-9. 2005
    ..Our aim is to evaluate the correlation between 13C-UBT values and H. pylori bacterial load...
  36. ncbi Relationships between the lung clearance index and conductive and acinar ventilation heterogeneity
    Sylvia Verbanck
    Respiratory Division, Univ Hospital UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    J Appl Physiol (1985) 112:782-90. 2012
    ..In the meantime, interpretations of LCI results in the clinic based on washout curves collected at the mouth should be handled with caution...
  37. ncbi Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus
    Stephen T Chambers
    University of Otago, Christchurch, New Zealand
    Med Mycol 49:S54-61. 2011
    ..is produced by extensive lung inflammation, and whether food containing high levels of 2PF can cause false positive breath tests either from contamination in the mouth or gastrointestinal absorption and subsequent excretion in the breath.
  38. pmc Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children
    Adam J Spanier
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatr Pulmonol 44:812-9. 2009
    ..We conclude that genetic differences may explain some of the conflicting results in studies of the effects of tobacco smoke exposure on FeNO levels and may make FeNO interpretation difficult for a subset of children with asthma...
  39. ncbi Portable exhaled nitric oxide measurement: Comparison with the "gold standard" technique
    Daniel Menzies
    Asthma and Allergy Research Group, Dundee, Scotland, UK
    Chest 131:410-4. 2007
    ..A portable nitric oxide analyzer (MINO; Aerocrine AB; Smidesvägen, Sweden) has been developed, but few data exist comparing this device with established, larger laboratory-based analyzers (NIOX; Aerocrine AB)...
  40. ncbi Choice of nasal nitric oxide technique as first-line test for primary ciliary dyskinesia
    J K Marthin
    Danish PCD Center, Paediatric Pulmonary Service, 5003, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur Respir J 37:559-65. 2011
    ..nNO is a helpful first-line tool in real-life PCD work-up in all age groups if the sampling method is chosen according to age. nNO can be misleading in a few patients with true PCD. Further studies are strongly needed in young children...
  41. ncbi Exhaled ethane: an in vivo biomarker of lipid peroxidation in interstitial lung diseases
    Soichiro Kanoh
    Third Department of Internal Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Chest 128:2387-92. 2005
    ..Oxidative stress plays a role in the pathogenesis and progression of interstitial lung disease (ILD). Exhaled ethane is a product of lipid peroxidation that has been proposed as a biomarker of oxidative stress in vivo...
  42. ncbi Association of lactose sensitivity with inflammatory bowel disease--demonstrated by analysis of genetic polymorphism, breath gases and symptoms
    P Eadala
    Department of Gastroenterology, Morriston Hospital, Swansea, UK
    Aliment Pharmacol Ther 34:735-46. 2011
    ..The genetic marker CC₁₃₉₁₀, on chromosome2, with measurement of breath hydrogen and methane, and gut and systemic symptoms, are now the most comprehensive tests for evaluating sensitivity to lactose...
  43. ncbi Fractionated exhaled breath condensate collection shows high hydrogen peroxide release in the airways
    Winfried Möller
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Clinical Cooperation Group Inflammatory Lung Diseases, Institute for Lung Biology and Disease iLBD, Gauting, Germany
    J Aerosol Med Pulm Drug Deliv 23:129-35. 2010
    ..However, there are still unresolved issues reflected by large variations in exhaled H(2)O(2) and uncertainties about the origin of H(2)O(2) release in the lung...
  44. pmc Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma
    Adam J Spanier
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Pediatr Pulmonol 43:576-83. 2008
    ..Clinicians and researchers may need to consider an individual's baseline FeNO levels to manage children with asthma...
  45. ncbi Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry
    Violetta Shestivska
    J Heyrovsky Institute of Physical Chemistry, Academy of Science of the Czech Republic, Prague, Czech Republic
    Rapid Commun Mass Spectrom 25:2459-67. 2011
    ..SIFT-MS was also used to analyze the breath of 28 children with CF and the concentrations of methyl thiocyanate were found to be in the range 2-21 ppbv (median 7 ppbv)...
  46. ncbi Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry
    Magdalena Ligor
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem Lab Med 47:550-60. 2009
    ..This might lead to a future diagnostic test for lung cancer...
  47. ncbi Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers
    A Rembert Koczulla
    Department of Internal Medicine, Division of Pulmonary Diseases, University Hospital Giessen and Marburg, Marburg, Germany koczulla med uni marburg de
    Respiration 79:61-7. 2010
    ..Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of inflammation...
  48. ncbi Assessment of exhaled breath condensate pH in exacerbations of asthma and chronic obstructive pulmonary disease: A longitudinal study
    Balazs Antus
    Department of Pathophysiology, National Koranyi Institute of TB and Pulmonology, Budapest, Hungary
    Am J Respir Crit Care Med 182:1492-7. 2010
    ..Exhaled breath condensate pH has been proposed as a noninvasive marker of airway inflammation. However, due to standardization difficulties in pH measurement techniques, different pH readings were obtained in previous studies...
  49. ncbi Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma
    Florence N Schleich
    Department of Pulmonary Medicine, CHU Sart Tilman, Liege, I GIGA Research Group, University of Liege, Belgium
    Thorax 65:1039-44. 2010
    ..However, the FeNO threshold value that identifies a sputum eosinophil count ≥3% in an unselected population of patients with asthma has been poorly studied...
  50. ncbi Diagnostic potential of breath analysis--focus on volatile organic compounds
    Wolfram Miekisch
    Department of Anaesthesia and Intensive Care Medicine, University Hospital of Rostock, Rostock, Germany
    Clin Chim Acta 347:25-39. 2004
    ..Analytical procedures, issues concerning biochemistry and exhalation mechanisms of volatile substances, and future developments will be discussed...
  51. ncbi Fraction of exhaled nitric oxide at 50 mL/s: reference values for adult lifelong never-smokers
    Anna Carin Olin
    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Box 414, SE 405 30 Goteborg, Sweden
    Chest 131:1852-6. 2007
    ..The measurement of fractional exhaled nitric oxide (FENO) is used as a marker of airway inflammation. The aim of this study was to establish reference values of FENO for adults...
  52. ncbi Analysis of volatile disease markers in blood
    W Miekisch
    Department of Anesthesiology and Intensive Care Medicine, University Hospital of Rostock, Schillingallee 35, 18057 Rostock, Germany
    Clin Chem 47:1053-60. 2001
    ..To overcome this problem, we developed a method to assess trace amounts of hydrocarbons (pentane and isoprene), ketones (acetone), halogenated compounds (isoflurane), and thioethers (dimethyl sulfide) in the blood of humans and animals...
  53. pmc Detection of lung cancer using weighted digital analysis of breath biomarkers
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024 6510, United States
    Clin Chim Acta 393:76-84. 2008
    ..We developed a non-linear method of multivariate analysis, weighted digital analysis (WDA), and evaluated its ability to predict lung cancer employing volatile biomarkers in the breath...
  54. ncbi The scent of Mycobacterium tuberculosis--part II breath
    Mona Syhre
    Otago University, Christchurch School of Medicine and Health Sciences, New Zealand
    Tuberculosis (Edinb) 89:263-6. 2009
    ..We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects...
  55. ncbi Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis
    P M Gustafsson
    Queens Silvia Children s Hospital and Department of Pediatrics, The Sahlgrenska Academy at Göteborg, Sweden
    Thorax 63:129-34. 2008
    ..A study was undertaken to determine the agreements between LCI and spirometry, respectively, with structural lung disease as measured by high-resolution computed tomography (HRCT) in children and teenagers with CF...
  56. ncbi Application of a new method for analysis of exhaled gas in critically ill patients
    J K Schubert
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Freiburg, Germany
    Intensive Care Med 24:415-21. 1998
    ..Application of a new method for analysis of exhaled gas in critically ill patients...
  57. ncbi Prediction of lung cancer using volatile biomarkers in breath
    Michael Phillips
    Menssana Research Inc, Fort Lee, NJ 07024 6510, USA
    Cancer Biomark 3:95-109. 2007
    ..g. alkanes). In patients with lung cancer, induction of high-risk cytochrome p450 genotypes may accelerate catabolism of these VOCs, so that their altered abundance in breath may provide biomarkers of lung cancer...
  58. ncbi The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication
    Mi Na Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Helicobacter 13:261-8. 2008
    ..This study was performed to evaluate whether the addition of probiotics to proton pump inhibitor (PPI)-based triple therapy increases the likelihood of successful Helicobacter pylori eradication...
  59. ncbi The effect of ambient air pollution on exhaled nitric oxide in the Children's Health Study
    K Berhane
    Dept of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Eur Respir J 37:1029-36. 2011
    ..In summary, short-term increases in PM₂.₅, PM₁₀ and O₃ were associated with airway inflammation independent of asthma and allergy status, with PM₁₀ effects significantly higher in the warm season...
  60. ncbi Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study
    J King
    University Clinic for Anesthesia, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Physiol Meas 31:1169-84. 2010
    ....
  61. pmc 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung
    Amy J Scott-Thomas
    Christchurch School of Medicine and Health Sciences, Department of Pathology, University of Otago, Christchurch, 8140, New Zealand
    BMC Pulm Med 10:56. 2010
    ..Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA)...
  62. ncbi Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease
    Massimo Corradi
    National Institute of Occupational Safety and Prevention Research Center, Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Italy
    Am J Respir Crit Care Med 167:1380-6. 2003
    ....
  63. ncbi High-viscosity liquid meal accelerates gastric emptying
    Y Shimoyama
    Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan
    Neurogastroenterol Motil 19:879-86. 2007
    ..5 +/- 6.03 vs 125.8 +/- 4.69 microM mL(-1), P < 0.05). In healthy individuals, pectin increased the viscosity of enteral nutrition and accelerated gastric emptying...
  64. pmc Exhaled nitric oxide in a population-based study of southern California schoolchildren
    William S Linn
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Respir Res 10:28. 2009
    ..Our aim was to identify significant predictors of FeNO in an initial cross-sectional survey of southern California schoolchildren, part of a larger longitudinal study of asthma incidence...
  65. ncbi Fructose malabsorption is associated with decreased plasma tryptophan
    M Ledochowski
    Dept of Clinical Nutrition, Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Scand J Gastroenterol 36:367-71. 2001
    ..Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism...
  66. pmc Exhaled nitric oxide levels in non-allergic and allergic mono- or polysensitised children with asthma
    M Silvestri
    Pulmonary Division, G. Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Thorax 56:857-62. 2001
    ..45, p<0.05). CONCLUSIONS: In children with mild asthma, a similar degree of functional disease severity may be associated with a higher inflammatory component in allergic than in non-allergic subjects...
  67. ncbi Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 25:252-8. 2010
    ..The link between food intake and symptom induction is recognized. This review aims to describe the evidence base for restricting rapidly fermentable, short-chain carbohydrates (FODMAPs) in controlling such symptoms...
  68. ncbi Breath markers and soluble lipid peroxidation markers in critically ill patients
    Joachim Scholpp
    Department of Anaesthesia, University Hospital of Freiburg, Germany
    Clin Chem Lab Med 40:587-94. 2002
    ..More detailed insights into inflammatory processes can be obtained when the volatile markers and the serum markers are considered together...
  69. pmc Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study
    Martha Scott
    The David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight PO30 5TG, UK
    Thorax 65:258-62. 2010
    ..Asthma is considered to be associated with elevated levels of exhaled nitric oxide (FeNO). The nature of this relationship and how it is influenced by atopy are still not resolved...
  70. ncbi Breath analysis: the approach towards clinical applications
    Anton Amann
    Department of Anaesthesia and General Intensive Care, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Mini Rev Med Chem 7:115-29. 2007
    ..Brief outlines are given of the research carried out to date, and prospects for the future of this potentially valuable non-invasive technique are indicated...
  71. ncbi Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers
    Michael McCulloch
    Pine Street Foundation, San Anselmo, California 94960, USA
    Integr Cancer Ther 5:30-9. 2006
    ..However, chemical analysis of exhaled breath has not shown suitability for individual clinical diagnosis...
  72. ncbi Exhaled breath condensate biomarkers in COPD
    Z L Borrill
    Medicines Evaluation Unit, Langley Building, The University of Manchester, Wythenshawe Hospital, Southmoor Rd, Manchester M23 9QZ, UK
    Eur Respir J 32:472-86. 2008
    ....
  73. pmc Exhaled nitric oxide correlates with airway eosinophils in childhood asthma
    T J Warke
    Department of Child Health, Institute of Clinical Science, Queen s University of Belfast, Belfast BT12 6BJ, N Ireland, UK
    Thorax 57:383-7. 2002
    ..The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children...
  74. ncbi The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    M A Berry
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:1175-9. 2005
    ..Nitric oxide (NO) has potential advantages as a tool to monitor airway inflammation although little is known about the relationship between NO and eosinophilic airway inflammation and the factors which influence it...
  75. pmc Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
    Stanley J Szefler
    National Jewish Health, Denver, CO, USA
    Lancet 372:1065-72. 2008
    ....
  76. ncbi A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis
    Xing Chen
    Biosensor National Special Laboratory, Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of National Education Ministry, Zhejiang University, Hangzhou PR China
    Cancer 110:835-44. 2007
    ....
  77. ncbi Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro-cecal transit time
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 25:6-10. 2006
    ..Quantitative culture of upper gut aspirate is used as a gold standard for the diagnosis of SIBO. Studies on diagnosis of SIBO using non-invasive hydrogen breath tests are contradictory.
  78. ncbi Exhaled breath condensate (EBC) biomarkers in pulmonary fibrosis
    Sharron Chow
    Department of Pathology, Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Kensington, Australia
    J Breath Res 6:016004. 2012
    ..In conclusion, inflammatory and oxidative stress biomarkers are raised in patients with PF compared with controls. EBC may be useful for detecting and monitoring lung inflammation in PF...
  79. pmc Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases
    M L Bartoli
    Cardiothoracic and Vascular Department, University of Pisa, Ospedale di Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Mediators Inflamm 2011:891752. 2011
    ..Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA)...
  80. pmc Exhaled breath condensate: an overview
    John Hunt
    Department of Pediatrics Pulmonology, Allergy and Immunology, Box 800386, University of Virginia, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 27:587-96; v. 2007
    ..Conscientious assay technique will likely find in EBC any substance of substantially high enough concentration in the airway lining fluid...
  81. pmc Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance
    I Narang
    Department of Paediatrics, Royal Brompton Hospital, Imperial School of Medicine, London SW3 6NP, UK
    Thorax 57:586-9. 2002
    ..The levels of exhaled and nasal nitric oxide (eNO and nNO) in groups of patients with inflammatory lung diseases are well documented but the diagnostic use of these measurements in an individual is unknown...
  82. ncbi A profile of volatile organic compounds in breath discriminates COPD patients from controls
    J J B N Van Berkel
    Department of Health Risk Analysis and Toxicology, Faculty of Health, Medicine and Life Sciences, Research Institute NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Respir Med 104:557-63. 2010
    ..We recently developed a methodological approach able to identify profiles of VOCs in breath unique for patient groups. Here we applied this recently developed methodology regarding diagnosis of COPD patients...
  83. ncbi An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 64:166-70. 2009
    ..We hypothesized that an electronic nose can discriminate patients with lung cancer from COPD patients and healthy controls by analyzing the VOC-profile in exhaled breath...
  84. ncbi Effect of proton pump inhibitors on the continuous real time (13)C-urea breath test
    Haim Shirin
    Department of Gastroenterology, The E Wolfson Medical Center, Holon, Tel Aviv University, Tel Aviv, Israel
    Am J Gastroenterol 98:46-50. 2003
    ..The aim of this study was to evaluate the accuracy of a new, continuous real time (13)C-urea breath test, BreathID, for the diagnosis of Helicobacter pylori in patients taking proton pump inhibitors (PPIs)...
  85. ncbi The use of exhaled nitric oxide in the diagnosis of asthma in school children
    Yakov Sivan
    Department of Pediatric Pulmonology, Critical Care and Sleep Medicine, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel
    J Pediatr 155:211-6. 2009
    ..To evaluate the yield of the fractional exhaled nitric oxide (FeNO) in the diagnosis of asthma compared with spirometry and induced sputum cytologic study in school-age children...
  86. ncbi Intestinal fructose transport and malabsorption in humans
    Hilary F Jones
    Mechanisms in Cell Biology and Disease Research Group, Sansom Institute for Health Research, Univ of South Australia, South Australia 5001, Australia
    Am J Physiol Gastrointest Liver Physiol 300:G202-6. 2011
    ..Understanding the relative roles of these transporters in humans will be crucial for establishing a mechanistic basis for fructose malabsorption in gastrointestinal patients...
  87. ncbi Independent information of nonspecific biomarkers in exhaled breath condensate
    Holger Dressel
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University, Ziemssenstrasse 1, Munich, Germany
    Respiration 80:401-9. 2010
    ..Exhaled breath condensate (EBC) has been used for diagnosing and monitoring respiratory disorders. For clinical purposes the assessment of easy-to-obtain nonspecific markers seems particularly interesting...
  88. ncbi Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose
    Akira D M Hattesohl
    Department for Internal Medicine, Division for Pulmonary Diseases, Philipps University Marburg, Marburg, Germany
    Respirology 16:1258-64. 2011
    ..To compare the volatile organic compound patterns of patients with COPD with and without alpha 1-antitrypsin (AAT) deficiency using electronic nose technology...
  89. ncbi Nitric oxide in the airways
    Glenis Scadding
    Royal National TNE Hospital, London, UK
    Curr Opin Otolaryngol Head Neck Surg 15:258-63. 2007
    ..This review briefly explains the basic facts about nitric oxide, which is entering clinical practice as a measure of lower airways inflammation and is likely also to be employed in otorhinolaryngological practice...
  90. pmc Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics
    Mary Y Yeh
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Respir Med 102:248-55. 2008
    ..Non-invasive sampling in the exhaled breath condensate (EBC) to monitor alveolar GSH would facilitate research in pulmonary oxidative stress...
  91. pmc Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis
    L R Narasimhan
    Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:4617-21. 2001
    ..83 for breath ammonia and creatinine correlation. These preliminary data indicate the possibility of using the real-time breath ammonia measurements for determining efficacy and endpoint of hemodialysis...
  92. ncbi Automated needle trap heart-cut GC/MS and needle trap comprehensive two-dimensional GC/TOF-MS for breath gas analysis in the clinical environment
    Maren Mieth
    Department of Anesthesiology and Intensive Care Medicine, University Rostock, Schillingallee 35, 18057 Rostock, Germany
    Anal Chem 82:2541-51. 2010
    ..Needle trap sampling in combination with hyphenated chromatographic techniques can thus be used to provide well-tailored solutions for complex problems occurring in clinical breath analysis...
  93. ncbi Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatment
    Fernando Fernández-Bañares
    Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
    Clin Nutr 25:824-31. 2006
    ..Gas-related complaints (i.e., passage of flatus), which are present in a subgroup of these patients, might be associated with carbohydrate malabsorption...
  94. ncbi Equally elevated concentrations of exhaled nitric oxide in nonatopic and low-sensitized atopic asthmatics
    Heikki Ekroos
    Division of Clinical Physiology and Nuclear Medicine, Laboratory Department, Helsinki University Hospital, Helsinki, Finland
    Respir Med 103:152-8. 2009
    ..Some studies show concentrations of exhaled nitric oxide (FENO) in nonatopic asthma and in healthy subjects to be similar, but include asthmatics on inhaled steroids, which is likely to interfere with the results...
  95. ncbi Non-invasive phenotyping using exhaled volatile organic compounds in asthma
    Baharudin Ibrahim
    Respiratory Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Thorax 66:804-9. 2011
    ..The authors aimed to identify specific patterns of breath VOCs in patients with asthma and in clinically relevant disease phenotypes...
  96. ncbi Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009
    Jeannette Guarner
    Department of Pathology and Laboratory Medicine, Emory University Hospital rm C179A, 1364 Clifton Rd, Atlanta, GA 30322, USA
    Eur J Pediatr 169:15-25. 2010
    ..Of the serologic tests, immunoblot has the best sensitivity. The urea breath tests have >75% sensitivity for detection of H. pylori before and after treatment...
  97. ncbi Exhaled pentane as a possible marker for survival and lipid peroxidation during radiotherapy for lung cancer--a pilot study
    Marika Crohns
    Department of Oncology, University of Tampere, Tampere, Finland
    Free Radic Res 43:965-74. 2009
    ..003). Elevated exhaled pentane levels before RT may be due to the lipid peroxidation burden associated with cancer. The decrease of lipid peroxidation markers during RT may be attributable to enhanced antioxidant defense mechanisms...
  98. ncbi An electronic nose distinguishes exhaled breath of patients with Malignant Pleural Mesothelioma from controls
    Silvano Dragonieri
    Department of Respiratory Diseases, University of Bari, Bari, Italy
    Lung Cancer 75:326-31. 2012
    ..Electronic noses capture the spectrum of exhaled volatile organic compounds (VOCs) providing a composite biomarker profile (breathprint)...
  99. ncbi Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial
    Mariëlle W Pijnenburg
    Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Am J Respir Crit Care Med 172:831-6. 2005
    ..Treatment guidelines are mainly symptom-driven but symptoms are not closely related to airway inflammation. The fraction of nitric oxide in exhaled air (FENO) is a marker of airway inflammation in asthma...
  100. ncbi Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE
    Daan Caudri
    Department of Pediatrics Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
    Thorax 65:801-7. 2010
    ..For clinicians it remains very difficult to predict whether preschool children with symptoms suggestive of asthma will develop asthma in later childhood...
  101. pmc Asthma outcomes: biomarkers
    Stanley J Szefler
    National Jewish Health, Denver, Colorado, USA
    J Allergy Clin Immunol 129:S9-23. 2012
    ..Measurement of biomarkers has been incorporated within clinical research studies of asthma to characterize the population and associate the disease with environmental and therapeutic effects...

Research Grants71

  1. A Novel Approach to Carbon-13 Breath Tests
    David Wagner; Fiscal Year: 2002
    DESCRIPTION (Applicant's abstract): Stable isotope medical diagnostic breath tests enjoy the advantages of being non-invasive, highly specific to detecting an invading organism or measuring organ function, and usually lower cost than ..
  2. FAMILIAL GLUCOSE GALACTOSE MALABSORPTION
    ERNEST WRIGHT; Fiscal Year: 2001
    ..Sugar absorption will be measured using H-breath tests to determine if carriers exhibit any symptoms of malabsorption...
  3. Measuring Alcohol Use Disorders at the Roadside
    C Furr Holden; Fiscal Year: 2006
    ..general, and more specifically, drivers with elevated blood alcohol concentrations as measured by standardized breath tests have current alcohol problems...
  4. Sex Differences to Effects of Nicotine on Responses Maintained by Environmental S
    BETHANY RAIFF; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Oral H. pylori Prevalence in Intellectually/Developmentally Disabled Adults
    Catherine Binkley; Fiscal Year: 2009
    ..ID/DD and 112 control subjects will involve oral examinations, indices, dental plaque sampling, and C13 Urea Breath Tests at baseline to determine prevalence. Nested Polymerase Chain Reaction (PCR) analyses will be used to detect H...
  6. Exhaled Gas Biomarkers of Glucose Metabolism in T2DM subjects
    TIMOTHY DO CHAU MINH; Fiscal Year: 2013
    ..Large population screenings, including breath tests for not only glucose but also insulin and lipids, could also be conducted in populations for which blood draws ..
  7. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..b>Breath tests will be performed in 400 anonymized subjects in order to compare cancer-free controls (with a negative spiral ..
  8. CLINICAL PHARMACOLOGY CENTER
    LEON GOLDBERG; Fiscal Year: 1980
    ..4) Studies of breath tests in newborn rats and mice in which mothers were treated with a variety of xenobiotics demonstrated pronounced ..
  9. VALIDATION OF CAFFEINE/METHACETIN 13C BREATH TESTS
    David Wagner; Fiscal Year: 1992
    DESCRIPTION: (Adapted from the Applicant's Abstract). This study will investigate caffeine and methacetin breath tests in normal volunteers and validate the use of the tests for assessing hepatic cytochrome P450-IA2 activity...
  10. 13C-XYLOSE BREATH TEST FOR BACTERIAL OVERGROWTH
    David Wagner; Fiscal Year: 1991
    ..The need for a reliable, non-invasive screening test for bacterial overgrowth has led to the development of breath tests using radioactive (14 C) substrates...
  11. H. PYLORI BREATH TEST WITH INFRARED SPECTRAL DETECTION
    RONALD MICHEELS; Fiscal Year: 2000
    ..results, we plan to develop a commercial instrument that should make the 13C-urea breath test, as well as other breath tests utilizing 13CO2/13CO2 ratio analysis, accessible to a wide range of medical laboratories, physician offices, ..
  12. Breath Ammonia Method for H. pylori Detection
    David Putnam; Fiscal Year: 2003
    ..Phase I results demonstrated 100 percent agreement with conventional 14C-labeled breath tests The research will optimize the clinical instrumentation, expand the scope of the Phase I clinical trial to a ..
  13. 13 C - LABELED TRIOLEIN FOR DIAGNOSTIC BREATH TESTS
    DAVID KYLE; Fiscal Year: 1992
    ..By reducing this test cost and eliminating the ingestion of radioactive compounds, the triolein breath test should be more readily available to the clinician for diagnostic uses in women and children...
  14. Breath Analyzer for Determination of Dietary Fat
    JOERG KUTZNER; Fiscal Year: 2006
    ..pylori infections of the digestive tract. Although an established technique, breath tests will only be widely accepted and applied if cost effective devices are available...
  15. Estimating the Prevalence of Alcohol Use Disorders among At-Risk Drivers
    C Furr Holden; Fiscal Year: 2007
    ..in general, and more specifically drivers with elevated blood alcohol contents as measured by standardized breath tests have current alcohol problems...
  16. Innovative Laser Spectroscopic Approach for Breath Isoprene Detection
    JOERG KUTZNER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Breath tests are increasingly entering into medical diagnostics because of their non-invasive nature...
  17. NOVEL DIAGNOSTIC TOOL FOR BREATH DETECTION OF H PYLORI
    BARBARA PALDUS; Fiscal Year: 2000
    ..CRDS) instruments can measure 12CO2/13CO2 ratios with sensitivity comparable to mass spectroscopy in 13C-urea breath tests (UBT'S) for diagnosing infections by Helicobacter pylori...
  18. Lowering the drinking age: The New Zealand example
    Robert Voas; Fiscal Year: 2005
    ..abstract_text> ..
  19. ENHANCING ALCOHOL INTERLOCK EFFECTS ON 1ST DUI OFFENDERS
    Robert Voas; Fiscal Year: 2004
    ..This research builds on experience gained in a 5-year RO1-funded program in Alberta, Canada. ..
  20. Six Programs for the Future of Alcohol Safety
    Robert Voas; Fiscal Year: 2007
    ..Voas to become involved in a broader range of programs than if he otherwise were limited by taking on the full management of individual R01 projects. For this effort we are requesting 5 years of support for 75% of Dr. Voas' time. ..
  21. Campuses selling alcohol--Profit of Problem?
    Robert Voas; Fiscal Year: 2001
    ....
  22. Campuses selling alcohol--Profit of Problem?
    Robert Voas; Fiscal Year: 2005
    ....
  23. ENVIRONMENTAL PREVENTION OF COLLEGE ALCOHOL PROBLEMS
    Robert Voas; Fiscal Year: 2003
    ..abstract_text> ..
  24. Drivers with Alcohol Use Disorders: At high risk for crashes?
    Robert B Voas; Fiscal Year: 2010
    ..crash-involved drivers and 5,000 comparison drivers to participate in roadside interviews that will collect breath tests for BAC and oral fluid and blood samples to identify drug involvement...
  25. EVALUATION OF EFFORTS TO REDUCE BORDER BINGE DRINKING
    Robert Voas; Fiscal Year: 2002
    ..El Paso/Juarez, a border town with a similar border-binge drinking problem will, serve as a comparison site. ..
  26. VOLATILE MARKERS OF PULMONARY TUBERCULOSIS IN THE BREATH
    Michael Phillips; Fiscal Year: 2006
    ..Also, it could potentially reduce the mortality and morbidity caused by pulmonary TB. [unreadable] [unreadable] [unreadable]..
  27. VOLATILE MARKERS OF ORAL MALODOR IN THE BREATH
    Michael Phillips; Fiscal Year: 2004
    ....
  28. LASER BASED 13C ISOTOPE ANALYZER
    DANIEL MURNICK; Fiscal Year: 1992
    ..80% of those with stomach ulcers, replacing the radioactive 14C or mass spectrometer detected 13C labeled urea breath tests. The assay will be based on isotope shifts in the energy levels of the CO2 molecule...
  29. EXPERIMENTAL TESTING OF THE DESIGNATED DRIVER CONCEPT
    James Lange; Fiscal Year: 2003
    ..S. to Tijuana (and back). Alcohol breath tests are administered to participants when arriving and departing...
  30. Development of a Breath Analyzer for Asthma Screening
    Khosrow Namjou; Fiscal Year: 2002
    ..In collaboration with Allergy Clinic of Tulsa, at least 100 breath tests will be performed during Phase I.
  31. PATTERNS AND PREDICTORS IN THE ALCOHOL INTERLOCK RECORD
    Paul Marques; Fiscal Year: 2002
    ..In a recent analysis based on 5.5 million breath tests provided by over 2000 interlock assigned DUI offenders in Alberta, it was found that the rate of fail-level BAC ..
  32. Alcohol Interlock and Biomarker Prediction of DUI Risk
    Paul Marques; Fiscal Year: 2007
    ..In addition to scientific communication through usual channels, this project will create risk profile guidelines to aid motor vehicle authorities and the courts for using indicator evidence proactively. ..
  33. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  34. Brief Intervention in the ER in Poland
    Cheryl Cherpitel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Effects of Nicotine on Environmental Stimuli
    Jesse Dallery; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  36. Reducing High-Risk College Drinking Environments
    John Clapp; Fiscal Year: 2008
    ..The proposed research program is designed to systematically address gaps in the literature concerning environmental prevention among college students. ..
  37. Impulsivity and Treatments for Relapse Prevention in Smo
    Jesse Dallery; Fiscal Year: 2004
    ..g., cue exposure, contextual factors, nicotine deprivation, drugs of abuse, pharmacotherapies, stress, etc) affect the impulsive choices that lead to or prevent relapse. ..
  38. A home-based behavioral treatment for cigarette smoking
    Jesse Dallery; Fiscal Year: 2009
    ..As such, it may hold significant promise as a way to reduce the high rates of morbidity and mortality associated with smoking. ..
  39. Alcohol and Injury: New Knowledge from ER Studies
    Cheryl Cherpitel; Fiscal Year: 2005
    ....
  40. ALCOHOL AND INJURY IN EMERGENCY ROOMS IN POLAND
    Cheryl Cherpitel; Fiscal Year: 2003
    ....
  41. A home-based behavioral treatment for cigarette smoking
    Jesse Dallery; Fiscal Year: 2004
    ..abstract_text> ..
  42. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..abstract_text> ..
  43. Effect of 14 Underage Drinking Laws on Youthful Deaths
    James Fell; Fiscal Year: 2006
    ..abstract_text> ..
  44. Models for examining selective effects of pharmacotherapy on reinforced behaviors
    BRETT GINSBURG; Fiscal Year: 2008
    ..This project will clarify important factors involved in studies of alcohol effects and potential medications for alcoholics. [unreadable] [unreadable] [unreadable]..
  45. Age, ethanol, and strain effects on the behavioral pharmacology of cannabinoids
    BRETT GINSBURG; Fiscal Year: 2008
    ..This project will help us understand how aging, exposure to ethanol, and perhaps genetic disposition change the behavioral response to these drugs. [unreadable] [unreadable] [unreadable]..
  46. The Relationship of Impulsivity to Symptoms of Suicide
    Donald Dougherty; Fiscal Year: 2004
    ....
  47. An Evaluation of the Night Restriction and Passenger Limitation Components of Gra
    James Fell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  48. Exhaled Biomarkers During Treatment of Rhinovirus
    John Hunt; Fiscal Year: 2004
    ..The project will be conducted at the University of Virginia, where expertise in the study of the common cold, airway chemistry, and exhaled biomarkers is extensive. ..
  49. Guardian Angel Alcohol Test: The devil is in the details
    Mark Johnson; Fiscal Year: 2005
    ..This research not only has practical implications by validating the GA test, but also theoretical implications regarding the role of BAC feedback in general. ..
  50. Moderating Social Norms Interventions: Field Experiment
    Mark Johnson; Fiscal Year: 2009
    ..This research will help identify factors that might improve the efficacy of social norms interventions. ..
  51. Caregivers of Prolonged Mechanical Ventilation: Mind-Body Interaction Model
    Jiyeon Choi; Fiscal Year: 2010
    ..Improving caregivers'emotional and physical health may also improve the delivery of care as well as quality of life for the care recipient. ..
  52. Identifying the Antiplatelet Compounds of Garlic Ex Vivo
    Larry Lawson; Fiscal Year: 2005
    ..abstract_text> ..
  53. Impulsivity and Information Processing in Adolescent Cannabis Abuse
    Donald Dougherty; Fiscal Year: 2007
    ....
  54. AGGRESSION AND WOMEN--ALCOHOL AND SEROTONIN RELATIONSHIP
    Donald Dougherty; Fiscal Year: 2003
    ..These proposed studies will answer several questions regarding how alcohol, serotonin, premenstrual symptomatology, and the menstrual cycle are related to the susceptibility for aggressive behavior. ..
  55. Impulsivity Models: Behavioral Mechanisms
    Donald Dougherty; Fiscal Year: 2006
    ..This research will advance our understanding of the construct of impulsivity and will provide a firmer context within which future research can better study the role impulsivity plays in the development of severe conduct problems. ..
  56. Motivation and Information: Altering Drinkers' Behavior
    Mark Johnson; Fiscal Year: 2005
    ..Participants will be re-sampled as they return from Mexican bars, at which time their actual BAC levels will be measured. ..
  57. A Prospective Study of Drinking & Academic Performace
    Dennis Thombs; Fiscal Year: 2006
    ..The proposed study will inform both public health and higher education policy by filling knowledge gaps about the nature of the relation between college drinking and academic performance. ..
  58. Advances in noninvasive, fluid-less alcohol measurements
    TRENT RIDDER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Nicotine Replacement and Counseling In Adolescents
    Mark Rubinstein; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. Environmental Exposures, NOS Genes, and Exhaled Nitric Oxide in Pediatric Asthma
    Adam Spanier; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. Nitration immunology
    John Hunt; Fiscal Year: 2005
    ..This novel project may serve to elucidate an important link between innate and acquired immunity--identifying a highly novel mechanism for both inciting and regulating immune responses. ..
  62. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  63. Alcohol in Aviation and Motor Carriers
    Guohua Li; Fiscal Year: 2010
    ..Findings from theproposed research couldprovide much-neededscientific evidence for informing important policy decisions relevant to transportation safety andprotection of the traveling public. ..
  64. Nitric Oxide/Carbon Monoxide in Pulmonary Hypertention
    Raed Dweik; Fiscal Year: 2006
    ..The training component of this proposal will lead to the candidate's transition to a fully independent investigator. ..
  65. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  66. Progesterone Treatment for Cocaine-Dependent Women
    Suzette Evans; Fiscal Year: 2009
    ..e., women who primarily use cocaine by other routes other than smoked). ..
  67. Smoking Cessation for Head and Neck Cancer Patients
    Robert Schnoll; Fiscal Year: 2006
    ..In turn, our findings may help guide the implementation of smoking cessation treatments for all cancer patients within Comprehensive Cancer Centers in the US. ..
  68. Effects of Smoked Heroin Across the Menstrual Cycle
    Suzette Evans; Fiscal Year: 2005
    ..The proposed studies will be the first to systematically evaluate these effects in female non-human primates. ..